Poul Sorensen
PhD, MD
Investigator, Michael Cuccione Childhood Cancer Research Program, BC Children's Hospital
Cristiano Ferrario and John Mackey and Karen A. Gelmon and Nathalie Levasseur and Poul H. Sorensen and Htoo Zarni Oo and Gian L. Negri and Veronica W.L. Tse and Sandra E. Spencer and Grace Cheng and Gregg B. Morin and Sonia del Rincon and Tiziana Cotechini and Christophe Gonalves and Charles C.T. Hindmarch and Wilson H. Miller and Mehdi Amiri and Tayebeh Basiri and Victor Villareal-Corpuz and Sam Sperry and Kevin Gregorczyk and Gonzalo Spera and Nahum Sonenberg and Michael Pollak
DOI: 10.1158/1078-0432.2833273602 / 2025
Cristiano Ferrario and John Mackey and Karen A. Gelmon and Nathalie Levasseur and Poul H. Sorensen and Htoo Zarni Oo and Gian L. Negri and Veronica W.L. Tse and Sandra E. Spencer and Grace Cheng and Gregg B. Morin and Sonia del Rincon and Tiziana Cotechini and Christophe Gonalves and Charles C.T. Hindmarch and Wilson H. Miller and Mehdi Amiri and Tayebeh Basiri and Victor Villareal-Corpuz and Sam Sperry and Kevin Gregorczyk and Gonzalo Spera and Nahum Sonenberg and Michael Pollak
DOI: 10.1158/1078-0432.2833269102 / 2025
Cristiano Ferrario and John Mackey and Karen A. Gelmon and Nathalie Levasseur and Poul H. Sorensen and Htoo Zarni Oo and Gian L. Negri and Veronica W.L. Tse and Sandra E. Spencer and Grace Cheng and Gregg B. Morin and Sonia del Rincon and Tiziana Cotechini and Christophe Gonalves and Charles C.T. Hindmarch and Wilson H. Miller and Mehdi Amiri and Tayebeh Basiri and Victor Villareal-Corpuz and Sam Sperry and Kevin Gregorczyk and Gonzalo Spera and Nahum Sonenberg and Michael Pollak
DOI: 10.1158/1078-0432.2833270902 / 2025
Cristiano Ferrario and John Mackey and Karen A. Gelmon and Nathalie Levasseur and Poul H. Sorensen and Htoo Zarni Oo and Gian L. Negri and Veronica W.L. Tse and Sandra E. Spencer and Grace Cheng and Gregg B. Morin and Sonia del Rincon and Tiziana Cotechini and Christophe Gonalves and Charles C.T. Hindmarch and Wilson H. Miller and Mehdi Amiri and Tayebeh Basiri and Victor Villareal-Corpuz and Sam Sperry and Kevin Gregorczyk and Gonzalo Spera and Nahum Sonenberg and Michael Pollak
DOI: 10.1158/1078-0432.2833274502 / 2025
Cristiano Ferrario and John Mackey and Karen A. Gelmon and Nathalie Levasseur and Poul H. Sorensen and Htoo Zarni Oo and Gian L. Negri and Veronica W.L. Tse and Sandra E. Spencer and Grace Cheng and Gregg B. Morin and Sonia del Rincon and Tiziana Cotechini and Christophe Gonalves and Charles C.T. Hindmarch and Wilson H. Miller and Mehdi Amiri and Tayebeh Basiri and Victor Villareal-Corpuz and Sam Sperry and Kevin Gregorczyk and Gonzalo Spera and Nahum Sonenberg and Michael Pollak
DOI: 10.1158/1078-0432.2833270302 / 2025
Cristiano Ferrario and John Mackey and Karen A. Gelmon and Nathalie Levasseur and Poul H. Sorensen and Htoo Zarni Oo and Gian L. Negri and Veronica W.L. Tse and Sandra E. Spencer and Grace Cheng and Gregg B. Morin and Sonia del Rincon and Tiziana Cotechini and Christophe Gonalves and Charles C.T. Hindmarch and Wilson H. Miller and Mehdi Amiri and Tayebeh Basiri and Victor Villareal-Corpuz and Sam Sperry and Kevin Gregorczyk and Gonzalo Spera and Nahum Sonenberg and Michael Pollak
DOI: 10.1158/1078-0432.2833269702 / 2025
Cristiano Ferrario and John Mackey and Karen A. Gelmon and Nathalie Levasseur and Poul H. Sorensen and Htoo Zarni Oo and Gian L. Negri and Veronica W.L. Tse and Sandra E. Spencer and Grace Cheng and Gregg B. Morin and Sonia del Rincon and Tiziana Cotechini and Christophe Gonalves and Charles C.T. Hindmarch and Wilson H. Miller and Mehdi Amiri and Tayebeh Basiri and Victor Villareal-Corpuz and Sam Sperry and Kevin Gregorczyk and Gonzalo Spera and Nahum Sonenberg and Michael Pollak
DOI: 10.1158/1078-0432.2833273902 / 2025
Cristiano Ferrario and John Mackey and Karen A. Gelmon and Nathalie Levasseur and Poul H. Sorensen and Htoo Zarni Oo and Gian L. Negri and Veronica W.L. Tse and Sandra E. Spencer and Grace Cheng and Gregg B. Morin and Sonia del Rincon and Tiziana Cotechini and Christophe Gonalves and Charles C.T. Hindmarch and Wilson H. Miller and Mehdi Amiri and Tayebeh Basiri and Victor Villareal-Corpuz and Sam Sperry and Kevin Gregorczyk and Gonzalo Spera and Nahum Sonenberg and Michael Pollak
DOI: 10.1158/1078-0432.2833274202 / 2025
Cristiano Ferrario and John Mackey and Karen A. Gelmon and Nathalie Levasseur and Poul H. Sorensen and Htoo Zarni Oo and Gian L. Negri and Veronica W.L. Tse and Sandra E. Spencer and Grace Cheng and Gregg B. Morin and Sonia del Rincon and Tiziana Cotechini and Christophe Gonalves and Charles C.T. Hindmarch and Wilson H. Miller and Mehdi Amiri and Tayebeh Basiri and Victor Villareal-Corpuz and Sam Sperry and Kevin Gregorczyk and Gonzalo Spera and Nahum Sonenberg and Michael Pollak
DOI: 10.1158/1078-0432.2833274802 / 2025
Cristiano Ferrario and John Mackey and Karen A. Gelmon and Nathalie Levasseur and Poul H. Sorensen and Htoo Zarni Oo and Gian L. Negri and Veronica W.L. Tse and Sandra E. Spencer and Grace Cheng and Gregg B. Morin and Sonia del Rincon and Tiziana Cotechini and Christophe Gonalves and Charles C.T. Hindmarch and Wilson H. Miller and Mehdi Amiri and Tayebeh Basiri and Victor Villareal-Corpuz and Sam Sperry and Kevin Gregorczyk and Gonzalo Spera and Nahum Sonenberg and Michael Pollak
DOI: 10.1158/1078-0432.2833271802 / 2025
Cristiano Ferrario and John Mackey and Karen A. Gelmon and Nathalie Levasseur and Poul H. Sorensen and Htoo Zarni Oo and Gian L. Negri and Veronica W.L. Tse and Sandra E. Spencer and Grace Cheng and Gregg B. Morin and Sonia del Rincon and Tiziana Cotechini and Christophe Gonalves and Charles C.T. Hindmarch and Wilson H. Miller and Mehdi Amiri and Tayebeh Basiri and Victor Villareal-Corpuz and Sam Sperry and Kevin Gregorczyk and Gonzalo Spera and Nahum Sonenberg and Michael Pollak
DOI: 10.1158/1078-0432.2833272102 / 2025
Cristiano Ferrario and John Mackey and Karen A. Gelmon and Nathalie Levasseur and Poul H. Sorensen and Htoo Zarni Oo and Gian L. Negri and Veronica W.L. Tse and Sandra E. Spencer and Grace Cheng and Gregg B. Morin and Sonia del Rincon and Tiziana Cotechini and Christophe Gonalves and Charles C.T. Hindmarch and Wilson H. Miller and Mehdi Amiri and Tayebeh Basiri and Victor Villareal-Corpuz and Sam Sperry and Kevin Gregorczyk and Gonzalo Spera and Nahum Sonenberg and Michael Pollak
DOI: 10.1158/1078-0432.2833273002 / 2025
Cristiano Ferrario and John Mackey and Karen A. Gelmon and Nathalie Levasseur and Poul H. Sorensen and Htoo Zarni Oo and Gian L. Negri and Veronica W.L. Tse and Sandra E. Spencer and Grace Cheng and Gregg B. Morin and Sonia del Rincon and Tiziana Cotechini and Christophe Gonalves and Charles C.T. Hindmarch and Wilson H. Miller and Mehdi Amiri and Tayebeh Basiri and Victor Villareal-Corpuz and Sam Sperry and Kevin Gregorczyk and Gonzalo Spera and Nahum Sonenberg and Michael Pollak
DOI: 10.1158/1078-0432.2833272402 / 2025
Cristiano Ferrario and John Mackey and Karen A. Gelmon and Nathalie Levasseur and Poul H. Sorensen and Htoo Zarni Oo and Gian L. Negri and Veronica W.L. Tse and Sandra E. Spencer and Grace Cheng and Gregg B. Morin and Sonia del Rincon and Tiziana Cotechini and Christophe Gonalves and Charles C.T. Hindmarch and Wilson H. Miller and Mehdi Amiri and Tayebeh Basiri and Victor Villareal-Corpuz and Sam Sperry and Kevin Gregorczyk and Gonzalo Spera and Nahum Sonenberg and Michael Pollak
DOI: 10.1158/1078-0432.2833270002 / 2025
Cristiano Ferrario and John Mackey and Karen A. Gelmon and Nathalie Levasseur and Poul H. Sorensen and Htoo Zarni Oo and Gian L. Negri and Veronica W.L. Tse and Sandra E. Spencer and Grace Cheng and Gregg B. Morin and Sonia del Rincon and Tiziana Cotechini and Christophe Gonalves and Charles C.T. Hindmarch and Wilson H. Miller and Mehdi Amiri and Tayebeh Basiri and Victor Villareal-Corpuz and Sam Sperry and Kevin Gregorczyk and Gonzalo Spera and Nahum Sonenberg and Michael Pollak
DOI: 10.1158/1078-0432.c.765499302 / 2025
Clinical Cancer Research
Cristiano Ferrario and John Mackey and Karen A. Gelmon and Nathalie Levasseur and Poul H. Sorensen and Htoo Zarni Oo and Gian L. Negri and Veronica W.L. Tse and Sandra E. Spencer and Grace Cheng and Gregg B. Morin and Sonia del Rincon and Tiziana Cotechini and Christophe Gonalves and Charles C.T. Hindmarch and Wilson H. Miller, Jr and Mehdi Amiri and Tayebeh Basiri and Victor Villareal-Corpuz and Sam Sperry and Kevin Gregorczyk and Gonzalo Spera and Nahum Sonenberg and Michael Pollak
DOI: 10.1158/1078-0432.CCR-24-084102 / 2025
Cristiano Ferrario and John Mackey and Karen A. Gelmon and Nathalie Levasseur and Poul H. Sorensen and Htoo Zarni Oo and Gian L. Negri and Veronica W.L. Tse and Sandra E. Spencer and Grace Cheng and Gregg B. Morin and Sonia del Rincon and Tiziana Cotechini and Christophe Gonalves and Charles C.T. Hindmarch and Wilson H. Miller and Mehdi Amiri and Tayebeh Basiri and Victor Villareal-Corpuz and Sam Sperry and Kevin Gregorczyk and Gonzalo Spera and Nahum Sonenberg and Michael Pollak
DOI: 10.1158/1078-0432.2833273302 / 2025
Cristiano Ferrario and John Mackey and Karen A. Gelmon and Nathalie Levasseur and Poul H. Sorensen and Htoo Zarni Oo and Gian L. Negri and Veronica W.L. Tse and Sandra E. Spencer and Grace Cheng and Gregg B. Morin and Sonia del Rincon and Tiziana Cotechini and Christophe Gonalves and Charles C.T. Hindmarch and Wilson H. Miller and Mehdi Amiri and Tayebeh Basiri and Victor Villareal-Corpuz and Sam Sperry and Kevin Gregorczyk and Gonzalo Spera and Nahum Sonenberg and Michael Pollak
DOI: 10.1158/1078-0432.2833272702 / 2025
Cristiano Ferrario and John Mackey and Karen A. Gelmon and Nathalie Levasseur and Poul H. Sorensen and Htoo Zarni Oo and Gian L. Negri and Veronica W.L. Tse and Sandra E. Spencer and Grace Cheng and Gregg B. Morin and Sonia del Rincon and Tiziana Cotechini and Christophe Gonalves and Charles C.T. Hindmarch and Wilson H. Miller and Mehdi Amiri and Tayebeh Basiri and Victor Villareal-Corpuz and Sam Sperry and Kevin Gregorczyk and Gonzalo Spera and Nahum Sonenberg and Michael Pollak
DOI: 10.1158/1078-0432.2833271502 / 2025
Cristiano Ferrario and John Mackey and Karen A. Gelmon and Nathalie Levasseur and Poul H. Sorensen and Htoo Zarni Oo and Gian L. Negri and Veronica W.L. Tse and Sandra E. Spencer and Grace Cheng and Gregg B. Morin and Sonia del Rincon and Tiziana Cotechini and Christophe Gonalves and Charles C.T. Hindmarch and Wilson H. Miller and Mehdi Amiri and Tayebeh Basiri and Victor Villareal-Corpuz and Sam Sperry and Kevin Gregorczyk and Gonzalo Spera and Nahum Sonenberg and Michael Pollak
DOI: 10.1158/1078-0432.2833271202 / 2025
Junran Yan and Forum Bhanshali and Chiaki Shuzenji and Tsultrim T. Mendenhall and Xuanjin Cheng and Pamela Bai and Gahan Diwan and Donna Seraj and Joel N. Meyer and Poul H. Sorensen and Jessica H. Hartman and Stefan Taubert
DOI: 10.1101/2024.03.20.58599303 / 2024
Current Oncology
Betty Yao and Alberto Delaidelli and Hannes Vogel and Poul Sorensen
DOI: 10.3390/curroncol3005037905 / 2023
Acta Neuropathologica Communications
Albert Z. Huang and Alberto Delaidelli and Poul H. Sorensen
DOI: 10.1186/s40478-020-00941-612 / 2020
One of the hallmarks of advanced malignancies is the production by tumour cells of TGFß and, paradoxically, the inhibition of TGFß signaling in tumour cells. The group has found through microarray studies that TGFß is markedly up-regulated by the EN protein, and that EN inhibits TGFß signaling. Therefore EN transformation appears to an excellent model of the role TGFß in neoplasia.
IGFs are expressed in many pediatric malignancies, and it is thought that the IGFRI axis plays a key role in oncogenesis in these tumours. The group recently found that the ETV6-NTRK3 (EN) fusion protein fails to transform IGFRI -/- murine fibroblasts, but that re-introduction of IGFRI restores EN transformation activity. Ongoing studies are assessing mechanisms by which IGFRI complements dominantly acting fusion proteins.
The abundance of cyclin D1 is rate-limiting in G1 phase progression. The group has found, by microarray and other studies, that several pediatric sarcoma translocation-associated fusion oncoproteins markedly up-regulate cyclin D1 expression. The mechanism of over-expression is currently being assessed by studying transcriptional regulation (such as by the AP-1 and NFKB transcription factors), regulation by the generation of reactive oxygen species (ROS), and regulation of cyclin D1 protein stability by the PI3-kinase-AKT pathway.
UBC Pathology Award for Excellence in Research and Discovery - 2001
UBC Pathology Award for Excellence in Research and Discovery - 2014
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