Overview

My research interests are primarily in the psychopharmacology of schizophrenia. Some of my current projects include:

Antipsychotic polypharmacy in which we are studying prevalence, predictors, indicators and clinical outcomes associated with this relatively common prescribing practice that is not adequately supported by the literature or clinical practice guidelines;

Smoking and schizophrenia where we have and continue to investigate the relationship between tobacco consumption and antipsychotic treatment, self-reported motivations for why individuals with schizophrenia smoke, and predictors of starting to smoke in first episode patients;

The influence of serum lipids on clozapine’s clinical efficacy in which we are exploring possible mechanism(s) that underlie our previous work showing a positive correlation between serum triglycerides and clinical response to clozapine; and

The metabolic effects of antipsychotics where we are investigating the acute and chronic effects of the atypical antipsychotics on alterations in glucose and insulin parameters.

Publications

Exercise-induced hippocampal neurogenesis: 5-HT3 receptor antagonism by antipsychotics as a potential limiting factor in Schizophrenia
Molecular Psychiatry
David D. Kim and Alasdair M. Barr and William G. Honer and Ric M. Procyshyn
DOI: 10.1038/s41380-018-0022-8
12/2018

Antipsychotic-Associated Symptoms of Tourette Syndrome: A Systematic Review
CNS Drugs
David D. Kim and Alasdair M. Barr and Yunsun Chung and Jessica W. Y. Yuen and Mahyar Etminan and Bruce C. Carleton and Randall F. White and William G. Honer and Ric M. Procyshyn
DOI: 10.1007/s40263-018-0559-8
08/2018

Antipsychotic prescribing patterns on admission to and at discharge from a tertiary care program for treatment-resistant psychosis
PLOS ONE
Lik Hang N. Lee and Ric M. Procyshyn and Randall F. White and Todd S. Woodward and William G. Honer and Alasdair M. Barr
DOI: 10.1371/journal.pone.0199758
08/2018

A systematic review of the effects of CYP2D6 phenotypes on risperidone treatment in children and adolescents
Child and Adolescent Psychiatry and Mental Health
Thomas Dodsworth and David D. Kim and Ric M. Procyshyn and Colin J. Ross and William G. Honer and Alasdair M. Barr
DOI: 10.1186/s13034-018-0243-2
07/2018

Reversal of Dopamine Supersensitivity as a Mechanism of Action of Clozapine
Psychotherapy and Psychosomatics
David D. Kim and Alasdair M. Barr and William G. Honer and Ric M. Procyshyn
DOI: 10.1159/000491700
07/2018

Association of Antidepressant Use With Drug-Related Extrapyramidal Symptoms
Journal of Clinical Psychopharmacology
Michael Y. Guo and Mahyar Etminan and Ric M. Procyshyn and David D. Kim and Ali Samii and Abbas Kezouh and Bruce C. Carleton
DOI: 10.1097/jcp.0000000000000911
06/2018

Statin add-on therapy for schizophrenia: Is the effect the same for clozapine?
Psychiatry Research
David D. Kim and Alasdair M. Barr and Allen E. Thornton and William G. Honer and Ric M. Procyshyn
DOI: 10.1016/j.psychres.2018.02.039
05/2018

Reduced cardiovascular fitness associated with exposure to clozapine in individuals with chronic schizophrenia
Psychiatry Research
David D. Kim and Donna J. Lang and Ric M. Procyshyn and Melissa L. Woodward and Kai Kaufman and Randall F. White and William G. Honer and Darren E.R. Warburton
DOI: 10.1016/j.psychres.2018.01.029
04/2018

Clozapine-Induced Cardiovascular Side Effects and Autonomic Dysfunction: A Systematic Review
Frontiers in Neuroscience
Jessica W. Y. Yuen and David D. Kim and Ric M. Procyshyn and Randall F. White and William G. Honer and Alasdair M. Barr
DOI: 10.3389/fnins.2018.00203
04/2018

Clinical and functional characteristics of young adults living in single room occupancy housing: preliminary findings from a 10-year longitudinal study
Canadian Journal of Public Health
Skye P. Barbic and Andrea A. Jones and Melissa Woodward and Matt Piercy and Steve Mathias and Fidel Vila-Rodriguez and Olga Leonova and Geoffrey N. Smith and Tari Buchanan and Alexandra T. Vertinsky and Stephanie Gillingham and William J. Panenka and Alexander Rauscher and Alasdair M. Barr and Ric M. Procyshyn and G. William MacEwan and Donna J. Lang and Allen E. Thornton and Manraj K. Heran and Adelena M. Leon and Michael Krausz and William G. Honer
DOI: 10.17269/s41997-018-0087-9
04/2018

Effects of physical activity on the symptoms of Tourette syndrome: A systematic review
European Psychiatry
David D. Kim and Darren E.R. Warburton and Nana Wu and Alasdair M. Barr and William G. Honer and Ric M. Procyshyn
DOI: 10.1016/j.eurpsy.2017.11.002
02/2018

Risk of hair loss with different antidepressants
International Clinical Psychopharmacology
Mahyar Etminan and Mohit Sodhi and Ric M. Procyshyn and Michael Guo and Bruce C. Carleton
DOI: 10.1097/yic.0000000000000191
01/2018

Clozapine, elevated heart rate and QTc prolongation
Journal of Psychiatry & Neuroscience
David D. Kim and Randall F. White and Alasdair M. Barr and William G. Honer and Ric M. Procyshyn
DOI: 10.1503/jpn.170135
01/2018

Clinical Handbook of Psychotropic Drugs for Children and Adolescents
DOI: 10.1027/00550-000
2018

Risk of hair loss with different antidepressants: A comparative retrospective cohort study
International Clinical Psychopharmacology
Etminan, M. and Sodhi, M. and Procyshyn, R.M. and Guo, M. and Carleton, B.C.
DOI: 10.1097/YIC.0000000000000191
2018

Association of Antidepressant Use with Drug-Related Extrapyramidal Symptoms: A Pharmacoepidemiological Study
Journal of Clinical Psychopharmacology
Guo, M.Y. and Etminan, M. and Procyshyn, R.M. and Kim, D.D. and Samii, A. and Kezouh, A. and Carleton, B.C.
DOI: 10.1097/JCP.0000000000000911
2018

Heart-rate response to alpha2-adrenergic receptor antagonism by antipsychotics
Clinical Autonomic Research
David D. Kim and Donna J. Lang and Darren E. R. Warburton and Melissa L. Woodward and Randall F. White and Alasdair M. Barr and William G. Honer and Ric M. Procyshyn
DOI: 10.1007/s10286-017-0444-4
12/2017

Traumatic Brain Injury in a Community-Based Cohort of Homeless and Vulnerably Housed Individuals.
Journal of neurotrauma
Schmitt T and Thornton AE and Rawtaer I and Barr AM and Gicas KM and Lang DJ and Vertinsky AT and Rauscher A and Procyshyn RM and Buchanan T and Cheng A and MacKay S and Leonova O and Panenka WJ
DOI: 10.1089/neu.2017.5076
PubMed: 28741437
09/2017

Exercise-associated extrapyramidal symptoms during treatment with long-acting injectable antipsychotic medications: A case report.
Clinical schizophrenia & related psychoses
Kim DD and Lang DJ and Warburton DER and Barr AM and White RF and Honer WG and Procyshyn RM
DOI: 10.3371/csrp.dkdl.071317
PubMed: 28777027
08/2017

Housing First Improves Adherence to Antipsychotic Medication Among Formerly Homeless Adults With Schizophrenia: Results of a Randomized Controlled Trial.
Schizophrenia bulletin
Rezansoff SN and Moniruzzaman A and Fazel S and McCandless L and Procyshyn R and Somers JM
DOI: 10.1093/schbul/sbw136
PubMed: 27665002
07/2017

Effects of Exercise on Serum Triglycerides and Symptoms of Schizophrenia
Journal of Clinical Psychopharmacology
David D. Kim and Donna J. Lang and Darren E.R. Warburton and Alasdair M. Barr and Geoffrey N. Smith and Allen E. Thornton and Randall F. White and William G. Honer and Ric M. Procyshyn
DOI: 10.1097/jcp.0000000000000648
04/2017

M81. Atypical Antipsychotic Dose-Dependent Effects on Fractional Anisotropy in a Cohort of Chronic Schizophrenia Patients.
Schizophrenia bulletin
Lang D and Kim D and Woodward M and Procyshyn R and Thornton A and O’Connor T and Goghari V and White R and Leonova O and Su W and Rauscher A and Warburton D and Vertinsky T and Smith G and Honer W
DOI: 10.1093/schbul/sbx022.076
03/2017

SU48. A Comparison of Psychotic Symptoms in Subjects With Cocaine or Methamphetamine Dependence vs Schizophrenia Spectrum Disorder.
Schizophrenia bulletin
Alexander P and Gicas K and Willi T and Kim C and Boyeva V and Procyshyn R and Smith G and Thornton A and Panenka W and Jones A and Vila-Rodriguez F and Leonova O and Lang D and MacEwan W and Barr A
DOI: 10.1093/schbul/sbx024.046
03/2017

SU60. Risk and Protective Factors Associated With Psychotic Symptom Profiles of Marginally Housed Adults.
Schizophrenia bulletin
Jones A and Gicas K and Procyshyn R and Smith G and Vila-Rodriguez F and Leonova O and Langheimer V and Mitchell E and Dhir A and Willi T and Schmitt T and Lang D and Barr A and Honer W
DOI: 10.1093/schbul/sbx024.058
03/2017

The Hotel Study-Clinical and Health Service Effectiveness in a Cohort of Homeless or Marginally Housed Persons.
Canadian journal of psychiatry. Revue canadienne de psychiatrie
Honer WG and Cervantes-Larios A and Jones AA and Vila-Rodriguez F and Montaner JS and Tran H and Nham J and Panenka WJ and Lang DJ and Thornton AE and Vertinsky T and Barr AM and Schultz K
DOI: 10.1177/0706743717693781
PubMed: 28199798
02/2017

Risk of Gambling Disorder and Impulse Control Disorder With Aripiprazole, Pramipexole, and Ropinirole
Journal of Clinical Psychopharmacology
Mahyar Etminan and Mohit Sodhi and Ali Samii and Ric M. Procyshyn and Michael Guo and Bruce C. Carleton
DOI: 10.1097/jcp.0000000000000634
02/2017

A comparison of psychotic symptoms in subjects with methamphetamine versus cocaine dependence.
Psychopharmacology
Alexander PD and Gicas KM and Willi TS and Kim CN and Boyeva V and Procyshyn RM and Smith GN and Thornton AE and Panenka WJ and Jones AA and Vila-Rodriguez F and Lang DJ and Barr AM
DOI: 10.1007/s00213-017-4551-7
PubMed: 28190084
02/2017

Characterization of white matter integrity deficits in cocaine-dependent individuals with substance-induced psychosis compared with non-psychotic cocaine users
Addiction Biology
Willi, T.S. and Barr, A.M. and Gicas, K. and Lang, D.J. and Vila-Rodriguez, F. and Su, W. and Thornton, A.E. and Leonova, O. and Giesbrecht, C.J. and Procyshyn, R.M. and Rauscher, A. and MacEwan, W.G. and Honer, W.G. and Panenka, W.J.
DOI: 10.1111/adb.12363
2017

Clinical Handbook of Psychotropic Drugs
DOI: 10.1027/00496-000
2017

Effects of exercise on serum triglycerides and symptoms of schizophrenia
Journal of Clinical Psychopharmacology
Kim, D.D. and Lang, D.J. and Warburton, D.E.R. and Barr, A.M. and Smith, G.N. and Thornton, A.E. and White, R.F. and Honer, W.G. and Procyshyn, R.M.
DOI: 10.1097/JCP.0000000000000648
2017

Antipsychotic induced dopamine supersensitivity psychosis: A comprehensive review
Current Neuropharmacology
Yin, J. and Barr, A.M. and Ramos-Miguel, A. and Procyshyn, R.M.
DOI: 10.2174/1570159X14666160606093602
2017

Risk of Gambling Disorder and Impulse Control Disorder with Aripiprazole, Pramipexole, and Ropinirole: A Pharmacoepidemiologic Study
Journal of Clinical Psychopharmacology
Etminan, M. and Sodhi, M. and Samii, A. and Procyshyn, R.M. and Guo, M. and Carleton, B.C.
DOI: 10.1097/JCP.0000000000000634
2017

Response to the Letter to the Editor on "Paliperidone Palmitate Long-Acting Injectable Given Intramuscularly in the Deltoid Versus the Gluteal Muscle: Are They Therapeutically Equivalent?"
Journal of clinical psychopharmacology
Yin J and Lee LH and Barr AM and Honer WG and Procyshyn RM
DOI: 10.1097/jcp.0000000000000612
PubMed: 27811557
12/2016

Structural brain markers are differentially associated with neurocognitive profiles in socially marginalized people with multimorbid illness.
Neuropsychology
Gicas KM and Giesbrecht CJ and Panenka WJ and Lang DJ and Smith GN and Vila-Rodriguez F and Leonova O and Jones AA and Barr AM and Procyshyn RM and Buchanan T and MacEwan GW and Su W and Thornton AE
DOI: 10.1037/neu0000304
PubMed: 27643510
09/2016

Review of Clinical Handbook of Psychotropic Drugs for Children and Adolescents, 3rd Ed., edited by Dean Elbe, Kalyna Z. Bezchlibnyk-Butler, Adil S. Virani, and Ric M. Procyshyn
Journal of Child and Adolescent Psychopharmacology
Malgorzata Maria Relja and Mira Sachdev
DOI: 10.1089/cap.2016.29107.mmr
06/2016

Factors affecting severity of positive and negative symptoms of psychosis in a polysubstance using population with psychostimulant dependence
Psychiatry Research
Willi, T.S. and Honer, W.G. and Thornton, A.E. and Gicas, K. and Procyshyn, R.M. and Vila-Rodriguez, F. and Panenka, W.J. and Aleksic, A. and Leonova, O. and Jones, A.A. and MacEwan, G.W. and Barr, A.M.
DOI: 10.1016/j.psychres.2016.04.059
2016

Antipsychotic Induced Dopamine Supersensitivity Psychosis: A Comprehensive Review
Current Neuropharmacology
John Yin and Alasdair Barr and Alfredo Ramos-Miguel and Ric Procyshyn
DOI: 10.2174/1570159x14666160606093602
2016

Adherence to antipsychotic medication among homeless adults in Vancouver, Canada: a 15-year retrospective cohort study
Social Psychiatry and Psychiatric Epidemiology
Rezansoff, S.N. and Moniruzzaman, A. and Fazel, S. and Procyshyn, R. and Somers, J.M.
DOI: 10.1007/s00127-016-1259-7
2016

Subcortical grey matter alterations in cocaine dependent individuals with substance-induced psychosis compared to non-psychotic cocaine users
Schizophrenia Research
Willi, T.S. and Lang, D.J. and Honer, W.G. and Smith, G.N. and Thornton, A.E. and Panenka, W.J. and Procyshyn, R.M. and Vila-Rodriguez, F. and Su, W. and Vertinsky, A.T. and Leonova, O. and Rauscher, A. and MacEwan, G.W. and Barr, A.M.
DOI: 10.1016/j.schres.2016.08.001
2016

Risk of extrapyramidal adverse events with aripiprazole
Journal of Clinical Psychopharmacology
Etminan, M. and Procyshyn, R.M. and Samii, A. and Carleton, B.C.
DOI: 10.1097/JCP.0000000000000543
2016

A Tetra-Primer Amplification Refractory System Technique for the Cost-Effective and Novel Genotyping of Eight Single-Nucleotide Polymorphisms of the Catechol-O-Methyltransferase Gene
Genetic Testing and Molecular Biomarkers
Wang, C.K. and Aleksic, A. and Xu, M.S. and Procyshyn, R.M. and Ross, C.J. and Vila-Rodriguez, F. and Ramos-Miguel, A. and Yan, R. and Honer, W.G. and Barr, A.M.
DOI: 10.1089/gtmb.2015.0304
2016

Elevated clozapine plasma concentration secondary to a urinary tract infection: Proposed mechanisms
Journal of Psychiatry and Neuroscience
Lee, L.H.N. and White, R.F. and Barr, A.M. and Honer, W.G. and Procyshyn, R.M.
DOI: 10.1503/jpn.150156
2016

Proposing the Use of Partial AUC as an Adjunctive Measure in Establishing Bioequivalence Between Deltoid and Gluteal Administration of Long-Acting Injectable Antipsychotics
European Journal of Drug Metabolism and Pharmacokinetics
Lee, L.H.N. and Choi, C. and Gershkovich, P. and Barr, A.M. and Honer, W.G. and Procyshyn, R.M.
DOI: 10.1007/s13318-016-0348-z
2016

Breakthrough symptoms after switching long-acting injectable paliperidone palmitate from the gluteal to the deltoid site of administration
Journal of Psychiatry and Neuroscience
Procyshyn, R.M. and Banasch, J.L. and Barr, A.M. and Honer, W.G.
DOI: 10.1503/jpn.150206
2016

Cognition and Plasma Ratio of Clozapine to N-desmethylclozapine in Patients With Clozapine-Resistant Schizophrenia.
The American journal of psychiatry
Thornton AE and Procyshyn RM and Barr AM and MacEwan GW and Honer WG
DOI: 10.1176/appi.ajp.2015.15070899
PubMed: 26619773
12/2015

The Pharmacokinetics of Second-Generation Long-Acting Injectable Antipsychotics: Limitations of Monograph Values.
CNS drugs
Lee LH and Choi C and Collier AC and Barr AM and Honer WG and Procyshyn RM
DOI: 10.1007/s40263-015-0295-2
PubMed: 26585875
12/2015

White matter deficits assessed by diffusion tensor imaging and cognitive dysfunction in psychostimulant users with comorbid human immunodeficiency virus infection.
BMC research notes
Tang VM and Lang DJ and Giesbrecht CJ and Panenka WJ and Willi T and Procyshyn RM and Vila-Rodriguez F and Jenkins W and Lecomte T and Boyda HN and Aleksic A and MacEwan GW and Honer WG and Barr AM
DOI: 10.1186/s13104-015-1501-5
PubMed: 26423806
09/2015

Development of a cost-efficient novel method for rapid, concurrent genotyping of five common single nucleotide polymorphisms of the brain derived neurotrophic factor (BDNF) gene by tetra-primer amplification refractory mutation system.
International journal of methods in psychiatric research
Wang CK and Xu MS and Ross CJ and Lo R and Procyshyn RM and Vila-Rodriguez F and White RF and Honer WG and Barr AM
DOI: 10.1002/mpr.1475
PubMed: 26118823
06/2015

Clinical Handbook of Psychotropic Drugs
DOI: 10.1027/00474-000
05/2015

Response trajectories to clozapine in a secondary analysis of pivotal trials support using treatment response to subtype schizophrenia.
Canadian journal of psychiatry. Revue canadienne de psychiatrie
Honer WG and Jones AA and Thornton AE and Barr AM and Procyshyn RM and Vila-Rodriguez F
PubMed: 25886676
03/2015

Dimenhydrinate Use Disorder With Chronic Psychosis
Journal of Clinical Psychopharmacology
Randall F. White and William G. Honer and Ric M. Procyshyn and Fidel Vila-Rodriguez
DOI: 10.1097/jcp.0000000000000238
02/2015

Treatment of clozapine-associated weight gain: a systematic review.
European journal of clinical pharmacology
Whitney Z and Procyshyn RM and Fredrikson DH and Barr AM
DOI: 10.1007/s00228-015-1807-1
PubMed: 25627831
01/2015

Paliperidone Palmitate Long-Acting Injectable Given Intramuscularly in the Deltoid Versus the Gluteal Muscle: Are They Therapeutically Equivalent?
Journal of Clinical Psychopharmacology
Yin, J. and Collier, A.C. and Barr, A.M. and Honer, W.G. and Procyshyn, R.M.
DOI: 10.1097/JCP.0000000000000361
2015

Exercise prevents downregulation of hippocampal presynaptic proteins following olanzapine-elicited metabolic dysregulation in rats: Distinct roles of inhibitory and excitatory terminals
Neuroscience
Ramos-Miguel, A. and Honer, W.G. and Boyda, H.N. and Sawada, K. and Beasley, C.L. and Procyshyn, R.M. and Barr, A.M.
DOI: 10.1016/j.neuroscience.2015.06.022
2015

Therapeutic Drug Levels of Second Generation Antipsychotics in Youth: A Systematic Review
Journal of Child and Adolescent Psychopharmacology
Whitney, Z. and Boyda, H.N. and Procyshyn, R.M. and Elbe, D. and Black, T. and Eslami, A. and Barr, A.M.
DOI: 10.1089/cap.2014.0044
2015

Mortality from treatable illnesses in marginally housed adults: A prospective cohort study
BMJ Open
Jones, A.A. and Vila-Rodriguez, F. and Leonova, O. and Langheimer, V. and Lang, D.J. and Barr, A.M. and Procyshyn, R.M. and Smith, G.N. and Schultz, K. and Buchanan, T. and Krausz, M. and Montaner, J.S. and Macewan, G.W. and Rauscher, A. and Panenka, W.J. and Thornton, A.E. and Honer, W.G.
DOI: 10.1136/bmjopen-2015-008876
2015

Dimenhydrinate use disorder with chronic psychosis
Journal of Clinical Psychopharmacology
White, R.F. and Honer, W.G. and Procyshyn, R.M. and Vila-Rodriguez, F.
DOI: 10.1097/JCP.0000000000000238
2015

Managing ADHD and disruptive behaviour disorders with combination psychostimulant and antipsychotic treatment.
Journal of psychiatry & neuroscience : JPN
Elbe D and Barr AM and Honer WG and Procyshyn RM
DOI: 10.1503/jpn.130288
PubMed: 24758945
05/2014

Pharmacological treatment of antipsychotic-induced dyslipidemia and hypertension
International Clinical Psychopharmacology
Lurdes Tse and Ric M. Procyshyn and Diane H. Fredrikson and Heidi N. Boyda and William G. Honer and Alasdair M. Barr
DOI: 10.1097/yic.0000000000000014
05/2014

Prevalence and patterns of antipsychotic use in youth at the time of admission and discharge from an inpatient psychiatric facility.
Journal of clinical psychopharmacology
Procyshyn RM and Su J and Elbe D and Liu AY and Panenka WJ and Davidson J and Honer WG and Barr AM
DOI: 10.1097/jcp.0b013e3182a607dd
PubMed: 24346744
02/2014

Clozapine administered once versus twice daily: Does it make a difference?
Medical Hypotheses
Procyshyn, R.M. and Vila-Rodriguez, F. and Honer, W.G. and Barr, A.M.
DOI: 10.1016/j.mehy.2013.11.043
2014

Clinical Handbook of Psychotropic Drugs for Children and Adolescents
DOI: 10.1027/00456-000
2014

An evaluation of the effects of the novel antipsychotic drug lurasidone on glucose tolerance and insulin resistance: A comparison with olanzapine
PLoS ONE
Wu, C. and Yuen, J. and Boyda, H.N. and Procyshyn, R.M. and Wang, C.K. and Asiri, Y.I. and Pang, C.C.Y. and Honer, W.G. and Barr, A.M.
DOI: 10.1371/journal.pone.0107116
2014

Cardiovascular effects of acute treatment with the antipsychotic drug olanzapine in rats
Vascular pharmacology
Leung, J.Y. and Pang, C.C. and Procyshyn, R.M. and Barr, A.M.
DOI: 10.1016/j.vph.2014.06.003
2014

Neurocognitive profiles of marginally housed persons with comorbid substance dependence, viral infection, and psychiatric illness
Journal of Clinical and Experimental Neuropsychology
Gicas, K.M. and Vila-Rodriguez, F. and Paquet, K. and Barr, A.M. and Procyshyn, R.M. and Lang, D.J. and Smith, G.N. and Baitz, H.A. and Giesbrecht, C.J. and Montaner, J.S. and Krajden, M. and Krausz, M. and MacEwan, G.W. and Panenka, W.J. and Honer, W.G. and Thornton, A.E.
DOI: 10.1080/13803395.2014.963519
2014

Pharmacological treatment of antipsychotic-induced dyslipidemia and hypertension
International Clinical Psychopharmacology
Tse, L. and Procyshyn, R.M. and Fredrikson, D.H. and Boyda, H.N. and Honer, W.G. and Barr, A.M.
DOI: 10.1097/YIC.0000000000000014
2014

Effects of chronic exercise and treatment with the antipsychotic drug olanzapine on hippocampal volume in adult female rats.
Neuroscience
Barr AM and Wu CH and Wong C and Hercher C and Töpfer E and Boyda HN and Procyshyn RM and Honer WG and Beasley CL
DOI: 10.1016/j.neuroscience.2013.10.010
PubMed: 24141179
10/2013

A retrospective study of antipsychotic drug switching in a pediatric population
BMC Psychiatry
David Linton and Ric M Procyshyn and Dean Elbe and Lik Hang N Lee and Alasdair M Barr
DOI: 10.1186/1471-244x-13-248
10/2013

Antidiabetic-drug combination treatment for glucose intolerance in adult female rats treated acutely with olanzapine.
Progress in neuro-psychopharmacology & biological psychiatry
Boyda HN and Procyshyn RM and Asiri Y and Wu C and Wang CK and Lo R and Pang CC and Honer WG and Barr AM
DOI: 10.1016/j.pnpbp.2013.10.006
PubMed: 24140931
10/2013

Routine exercise ameliorates the metabolic side-effects of treatment with the atypical antipsychotic drug olanzapine in rats.
The international journal of neuropsychopharmacology
Boyda HN and Ramos-Miguel A and Procyshyn RM and Töpfer E and Lant N and Choy HH and Wong R and Li L and Pang CC and Honer WG and Barr AM
DOI: 10.1017/s1461145713000795
PubMed: 23953063
08/2013

Metabolic side-effects of the novel second-generation antipsychotic drugs asenapine and iloperidone: a comparison with olanzapine.
PloS one
Boyda HN and Procyshyn RM and Pang CC and Hawkes E and Wong D and Jin CH and Honer WG and Barr AM
DOI: 10.1371/journal.pone.0053459
PubMed: 23326434
01/2013

A retrospective study of antipsychotic drug switching in a pediatric population
BMC Psychiatry
Linton, D. and Procyshyn, R.M. and Elbe, D. and Lee, L.H.N. and Barr, A.M.
DOI: 10.1186/1471-244X-13-248
2013

Antipsychotic and psychostimulant drug combination therapy in attention deficit/hyperactivity and disruptive behavior disorders: A systematic review of efficacy and tolerability
Current Psychiatry Reports
Linton, D. and Barr, A.M. and Honer, W.G. and Procyshyn, R.M.
DOI: 10.1007/s11920-013-0355-6
2013

Antipsychotic polypharmacy increases metabolic dysregulation in female rats
Experimental and Clinical Psychopharmacology
Boyda, H.N. and Procyshyn, R.M. and Tse, L. and Xu, J. and Jin, C. and Wong, D. and Pang, C.C. and Honer, W.G. and Barr, A.M.
DOI: 10.1037/a0031228
2013

Management of Medication-Related Cardiometabolic Risk in Patients with Severe Mental Illness
Current Cardiovascular Risk Reports
Lang, D.J. and Barr, A.M. and Procyshyn, R.M.
DOI: 10.1007/s12170-013-0321-1
2013

Peripheral adrenoceptors: The impetus behind glucose dysregulation and insulin resistance
Journal of Neuroendocrinology
Boyda, H.N. and Procyshyn, R.M. and Pang, C.C.Y. and Barr, A.M.
DOI: 10.1111/jne.12002
2013

Symptom changes in five dimensions of the Positive and Negative Syndrome Scale in refractory psychosis
European Archives of Psychiatry and Clinical Neuroscience
Woodward, T.S. and Jung, K. and Smith, G.N. and Hwang, H. and Barr, A.M. and Procyshyn, R.M. and Flynn, S.W. and van der Gaag, M. and Honer, W.G.
DOI: 10.1007/s00406-013-0460-x
2013

The hotel study: Multimorbidity in a community sample living in marginal housing
American Journal of Psychiatry
Vila-Rodriguez, F. and Panenka, W.J. and Lang, D.J. and Thornton, A.E. and Vertinsky, T. and Wong, H. and Barr, A.M. and Procyshyn, R.M. and Sidhu, J.J. and Smith, G.N. and Buchanan, T. and Krajden, M. and Krausz, M. and Montaner, J.S. and MacEwan, G.W. and Honer, W.G.
DOI: 10.1176/appi.ajp.2013.12111439
2013

Methamphetamine use: A comprehensive review of molecular, preclinical and clinical findings
Drug and Alcohol Dependence
Panenka, W.J. and Procyshyn, R.M. and Lecomte, T. and MacEwan, G.W. and Flynn, S.W. and Honer, W.G. and Barr, A.M.
DOI: 10.1016/j.drugalcdep.2012.11.016
2013

Personalized risk assessment of drug-related harm is associated with health outcomes
PLoS ONE
Jones, A.A. and Vila-Rodriguez, F. and Panenka, W.J. and Leonova, O. and Strehlau, V. and Lang, D.J. and Thornton, A.E. and Wong, H. and Barr, A.M. and Procyshyn, R.M. and Smith, G.N. and Buchanan, T. and Krajden, M. and Krausz, M. and Montaner, J.S. and MacEwan, G.W. and Nutt, D.J. and Honer, W.G.
DOI: 10.1371/journal.pone.0079754
2013

POSTERS.
European journal of psychotraumatology
DOI: 10.3402/ejpt.v3i0.19319
09/2012

Book Review: Clinical handbook of psychotropic drugs, 19th revised edition
Mental Health Clinician
Adil S. Virani and Kalyna Z. Bezchlibnyk-Butler and J. Joel Jeffries and Ric M. Procyshyn and Talia Puzantian
DOI: 10.9740/mhc.n104535
05/2012

Antipsychotic Medications: Linking Receptor Antagonism to Neuropsychological Functioning in First Episode Psychosis
Journal of the International Neuropsychological Society
Heather A. Baitz and Allen E. Thornton and Ric M. Procyshyn and Geoffrey N. Smith and G. William MacEwan and Lili C. Kopala and Alasdair M. Barr and Donna J. Lang and William G. Honer
DOI: 10.1017/s1355617712000343
04/2012

Cardiovascular side-effects of antipsychotic drugs: The role of the autonomic nervous system
Pharmacology and Therapeutics
Leung, J.Y.T. and Barr, A.M. and Procyshyn, R.M. and Honer, W.G. and Pang, C.C.Y.
DOI: 10.1016/j.pharmthera.2012.04.003
2012

Adverse events associated with switching antipsychotics
Journal of Psychiatry and Neuroscience
Su, J. and Barr, A.M. and Procyshyn, R.M.
DOI: 10.1503/jpn.110096
2012

Intermittent treatment with olanzapine causes sensitization of the metabolic side-effects in rats
Neuropharmacology
Boyda, H.N. and Procyshyn, R.M. and Tse, L. and Wong, D. and Pang, C.C. and Honer, W.G. and Barr, A.M.
DOI: 10.1016/j.neuropharm.2011.02.019
2012

Differential effects of 3 classes of antidiabetic drugs on olanzapine-induced glucose dysregulation and insulin resistance in female rats
Journal of Psychiatry and Neuroscience
Boyda, H.N. and Procyshyn, R.M. and Tse, L. and Hawkes, E. and Jin, C.H. and Pang, C.C.Y. and Honer, W.G. and Barr, A.M.
DOI: 10.1503/jpn.110140
2012

Antipsychotic medications: Linking receptor antagonism to neuropsychological functioning in first episode psychosis
Journal of the International Neuropsychological Society
Baitz, H.A. and Thornton, A.E. and Procyshyn, R.M. and Smith, G.N. and MacEwan, G.W. and Kopala, L.C. and Barr, A.M. and Lang, D.J. and Honer, W.G.
DOI: 10.1017/S1355617712000343
2012

Excessive antipsychotic dosing in a canadian outpatient population
Psychiatric Services
Barr, A.M. and Panenka, W.J. and Honer, W.G. and Khara, S. and Procyshyn, R.M.
DOI: 10.1176/ps.62.6.pss6206_0682a
2011

A comparison of antipsychotic drug-defined daily doses versus chlorpromazine equivalent doses in patients with or without extrapyramidal motor symptoms.
Journal of clinical psychopharmacology
Barr AM and Honer WG and Johnson JL and Wu TK and Procyshyn RM
DOI: 10.1097/jcp.0b013e3181fab7ca
PubMed: 21057241
12/2010

Gender-specific profiles of tobacco use among non-institutionalized people with serious mental illness
BMC Psychiatry
Joy L Johnson and Pamela A Ratner and Leslie A Malchy and Chizimuzo TC Okoli and Ric M Procyshyn and Joan L Bottorff and Marlee Groening and Annette Schultz and Marg Osborne
DOI: 10.1186/1471-244x-10-101
11/2010

Withdrawal
Animal Models of Drug Addiction
Alasdair M. Barr and Heidi N. Boyda and Ric M. Procyshyn
DOI: 10.1007/978-1-60761-934-5_16
10/2010

Medication errors in psychiatry: a comprehensive review.
CNS drugs
Procyshyn RM and Barr AM and Brickell T and Honer WG
DOI: 10.2165/11533710-000000000-00000
PubMed: 20356315
07/2010

Persistent Antipsychotic Polypharmacy and Excessive Dosing in the Community Psychiatric Treatment Setting
The Journal of Clinical Psychiatry
Ric M. Procyshyn and William G. Honer and Tony K. Y. Wu and Rebecca W. Y. Ko and Sean A. McIsaac and Allan H. Young and Joy L. Johnson and Alasdair M. Barr
DOI: 10.4088/jcp.08m04912gre
03/2010

Effect of hypertriglyceridemia on the pharmacokinetics and blood-brain barrier penetration of clozapine and norclozapine following administration to rats.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Gershkovich P and Sivak O and Sharma A and Barr AM and Procyshyn R and Wasan KM
DOI: 10.1016/j.euroneuro.2010.01.002
PubMed: 20163937
02/2010

Gender-specific profiles of tobacco use among non-institutionalized people with serious mental illness
BMC Psychiatry
Johnson, J.L. and Ratner, P.A. and Malchy, L.A. and Okoli, C.T.C. and Procyshyn, R.M. and Bottorff, J.L. and Groening, M. and Schultz, A. and Osborne, M.
DOI: 10.1186/1471-244X-10-101
2010

Memory Recall Processes Vary With Cocaine Exposure in Polysubstance Users
PsycEXTRA Dataset
Carmelina C. Barone and Heather A. Neilson and Chantelle J. Giesbrecht and Sasha M. Davis and Fidel Vila-Rodriguez and Gordon W. MacEwan and Alasdair M. Barr and Ric M. Procyshyn and Donna J. Lang and William G. Honer and Allen E. Thornton
DOI: 10.1037/e632942010-001
2010

A parametric study of the acute effects of antipsychotic drugs on glucose sensitivity in an animal model
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Boyda, H.N. and Tse, L. and Procyshyn, R.M. and Wong, D. and Wu, T.K.Y. and Pang, C.C. and Barr, A.M.
DOI: 10.1016/j.pnpbp.2010.04.024
2010

Preclinical models of antipsychotic drug-induced metabolic side effects
Trends in Pharmacological Sciences
Boyda, H.N. and Tse, L. and Procyshyn, R.M. and Honer, W.G. and Barr, A.M.
DOI: 10.1016/j.tips.2010.07.002
2010

Persistent antipsychotic polypharmacy and excessive dosing in the community psychiatric treatment setting: A review of medication profiles in 435 Canadian outpatients
Journal of Clinical Psychiatry
Procyshyn, R.M. and Honer, W.G. and Wu, T.K.Y. and Ko, R.W.Y. and McIsaac, S.A. and Young, A.H. and Johnson, J.L. and Barr, A.M.
DOI: 10.4088/JCP.08m04912gre
2010

Differential effects of alcohol intoxication on s100b levels following traumatic brain injury
Journal of Trauma - Injury, Infection and Critical Care
Lange, R.T. and Brubacher, J.R. and Iverson, G.L. and Procyshyn, R.M. and Mitrovic, S.
DOI: 10.1097/TA.0b013e3181bb9890
2010

Long-acting injectable risperidone in treatment refractory patients: A 14-week open-label pilot study
Schizophrenia Research
Procyshyn, R.M. and Barr, A.M. and Flynn, S. and Schenk, C. and Ganesan, S. and Honer, W.G.
DOI: 10.1016/j.schres.2010.07.016
2010

Smoking cessation interventions among individuals in methadone maintenance: a brief review.
Journal of substance abuse treatment
Okoli CT and Khara M and Procyshyn RM and Johnson JL and Barr AM and Greaves L
DOI: 10.1016/j.jsat.2009.10.001
PubMed: 20015608
12/2009

A translational research approach to poor treatment response in patients with schizophrenia: clozapine-antipsychotic polypharmacy.
Journal of psychiatry & neuroscience : JPN
Honer WG and Procyshyn RM and Chen EY and MacEwan GW and Barr AM
PubMed: 19949719
11/2009

Antipsychotic switching: results from a one-year prospective, observational study of patients with schizophrenia.
Current medical research and opinion
Karagianis J and Williams R and Davis L and Procyshyn R and Monga N and Hanley J and Chandrasena R and Thakur A and Dickson R
DOI: 10.1185/03007990903102966
PubMed: 19601707
09/2009

Do serum lipids predict response to clozapine treatment?
Journal of psychiatry & neuroscience : JPN
Procyshyn RM and Honer WG and Barr AM
PubMed: 19270766
03/2009

Predictors of starting to smoke cigarettes in patients with first episode psychosis.
Schizophrenia research
Smith GN and Wong H and MacEwan GW and Kopala LC and Ehmann TS and Thornton AE and Lang DJ and Barr AM and Procyshyn R and Austin JC and Flynn SW and Honer WG
DOI: 10.1016/j.schres.2008.12.013
PubMed: 19162444
01/2009

Community mental healthcare providers' attitudes and practices related to smoking cessation interventions for people living with severe mental illness
Patient Education and Counseling
Johnson, J.L. and Malchy, L.A. and Ratner, P.A. and Hossain, S. and Procyshyn, R.M. and Bottorff, J.L. and Groening, M. and Gibson, P. and Osborne, M. and Schultz, A.
DOI: 10.1016/j.pec.2009.02.013
2009

Anticholinergic Load and Verbal Memory in Early Psychosis
PsycEXTRA Dataset
Heather A. Neilson and Allen Thornton and Geoffrey N. Smith and Donna J. Lang and G. William Macewan and Lili C. Kopala and Ric Procyshyn and Alasdair M. Barr and William G. Honer
DOI: 10.1037/e614312009-001
2009

Self-reported motivation to smoke in schizophrenia is related to antipsychotic drug treatment.
Schizophrenia research
Barr AM and Procyshyn RM and Hui P and Johnson JL and Honer WG
DOI: 10.1016/j.schres.2007.11.027
PubMed: 18178062
01/2008

Antipsychotic polypharmacy does not increase the risk for side effects
Schizophrenia Research
Ganesan, S. and Taylor, R. and Forbes, I. and Rabheru, K. and Dumontet, J. and Procyshyn, R.M.
DOI: 10.1016/j.schres.2007.09.002
2008

Determination of clozapine and its metabolite, norclozapine in various biological matrices using high-performance liquid chromatography.
Drug development and industrial pharmacy
Rosland M and Szeto P and Procyshyn R and Barr AM and Wasan KM
DOI: 10.1080/03639040701484338
PubMed: 17963117
10/2007

Changes in serum lipids, independent of weight, are associated with changes in symptoms during long-term clozapine treatment.
Journal of psychiatry & neuroscience : JPN
Procyshyn RM and Wasan KM and Thornton AE and Barr AM and Chen EY and Pomarol-Clotet E and Stip E and Williams R and Macewan GW and Birmingham CL and Honer WG and Clozapine and Risperidone Enhancement Study Group
PubMed: 17823649
09/2007

Determination of clozapine and its metabolite, norclozapine in various biological matrices using high-performance liquid chromatography
Drug Development and Industrial Pharmacy
Rosland, M. and Szeto, P. and Procyshyn, R. and Barr, A.M. and Wasan, K.M.
DOI: 10.1080/03639040701484338
2007

Risperidone long-acting injection in the treatment of schizophrenia spectrum illnesses: A retrospective chart review of 19 patients in the Vancouver Community Mental Health Organization (Vancouver, Canada)
Current Therapeutic Research - Clinical and Experimental
Ganesan, S. and McKenna, M. and Procyshyn, R.M. and Zipursky, S.
DOI: 10.1016/j.curtheres.2007.12.002
2007

Conceptual and methodological issues in the design of clinical trials of antipsychotics for the treatment of schizophrenia
CNS Drugs
Honer, W.G. and Thornton, A.E. and Sherwood, M. and MacEwan, G.W. and Ehmann, T.S. and Williams, R. and Kopala, L.C. and Procyshyn, R. and Barr, A.M.
DOI: 10.2165/00023210-200721090-00001
2007

Clozapine alone versus clozapine and risperidone with refractory schizophrenia.
The New England journal of medicine
Honer WG and Thornton AE and Chen EY and Chan RC and Wong JO and Bergmann A and Falkai P and Pomarol-Clotet E and McKenna PJ and Stip E and Williams R and MacEwan GW and Wasan K and Clozapine and Risperidone Enhancement (CARE) Study Group
DOI: 10.1056/nejmoa053222
PubMed: 16452559
02/2006

Corrected QT intervals in newly admitted geriatric psychiatric patients: An examination of risk factors
Canadian Journal of Psychiatry
Dumontet, J. and Malyuk, R. and Kiang, G. and Procyshyn, R.M.
DOI: 10.1177/070674370605100606
2006

The effects of competitive displacement on haloperidol's plasma distribution in normolipidemic and hyperlipidemic plasma.
Drug development and industrial pharmacy
Procyshyn RM and Ho T and Wasan KM
DOI: 10.1080/03639040500272058
PubMed: 16306002
10/2005

Competitive displacement of clozapine from plasma proteins in normolipidemic and hyperlipidemic plasma samples: clinical implications.
Drug development and industrial pharmacy
Procyshyn RM and Ho T and Wasan KM
DOI: 10.1081/ddc-54305
PubMed: 16093198
05/2005

Competitive Displacement of Clozapine from Plasma Proteins in Normolipidemic and Hyperlipidemic Plasma Samples: Clinical Implications
Drug Development and Industrial Pharmacy
Ric Procyshyn and Tiffany Ho and Kishor Wasan
DOI: 10.1081/ddc-200054305
05/2005

Competitive Displacement of Clozapine from Plasma Proteins in Normolipidemic and Hyperlipidemic Plasma Samples: Clinical Implications
Drug Development and Industrial Pharmacy
Ric M. Procyshyn and Tiffany Ho and Kishor M. Wasan
DOI: 10.1081/ddc-54305
01/2005

Competitive displacement of clozapine from plasma proteins in normolipidemic and hyperlipidemic plasma samples: Clinical implications
Drug Development and Industrial Pharmacy
Procyshyn, R.M. and Ho, T. and Wasan, K.M.
DOI: 10.1081/DDC-54305
2005

Smoking, anticholinergics and schizophrenia
Schizophrenia Research
Ric M. Procyshyn and Deborah L. Thompson and Kaleena Patel
DOI: 10.1016/s0920-9964(02)00501-7
04/2004

Clozapine's effects on body weight and resting metabolic rate: a case series.
Schizophrenia research
Procyshyn RM and Chau A and Tse G
DOI: 10.1016/s0920-9964(03)00190-7
PubMed: 15061248
02/2004

Patterns of antipsychotic utilization in a tertiary care psychiatric institution.
Pharmacopsychiatry
Procyshyn RM and Thompson B
DOI: 10.1055/s-2004-815469
PubMed: 14750043
01/2004

Prevalence and outcomes of pharmaceuticals industry-sponsored clinical trials involving clozapine, risperidone, or olanzapine
Canadian Journal of Psychiatry
Procyshyn, R.M. and Chau, A. and Fortin, P. and Jenkins, W.
DOI: 10.1177/070674370404900905
2004

Smoking, anticholinergics and schizophrenia [5]
Schizophrenia Research
Procyshyn, R.M. and Patel, K. and Thompson, D.L.
DOI: 10.1016/S0920-9964(02)00501-7
2004

The influence of dyslipidemia on the plasma protein and lipoprotein distribution of haloperidol.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Procyshyn RM and Tsai G and Wasan KM
DOI: 10.1016/s0924-977x(02)00078-0
PubMed: 12480120
01/2003

Generic clozapine: A cost-saving alternative to brand name clozapine?
PharmacoEconomics
Tse, G. and Thompson, D. and Procyshyn, R.M.
DOI: 10.2165/00019053-200321010-00001
2003

Olanzapine associated weight gain, hyperglycemia and neuroleptic malignant syndrome: case report.
International journal of geriatric psychiatry
Malyuk R and Gibson B and Procyshyn RM and Kang N
DOI: 10.1002/gps.596
PubMed: 11994885
04/2002

Concomitant clozapine reduces smoking in patients treated with risperidone
European Neuropsychopharmacology
Procyshyn, R.M. and Flynn, S. and Sin, O. and Tse, G.
DOI: 10.1016/S0924-977X(01)00130-4
2002

Do triglycerides modulate the effectiveness of clozapine?
International Clinical Psychopharmacology
Pande, S. and Procyshyn, R.M. and Nazerali, M. and Attwood, D. and Chow, K.
DOI: 10.1097/00004850-200207000-00007
2002

A comparison of smoking behaviours between patients treated with clozapine and depot neuroleptics.
International clinical psychopharmacology
Procyshyn RM and Ihsan N and Thompson D
DOI: 10.1097/00004850-200109000-00007
PubMed: 11552773
09/2001

Plasma Protein and Lipoprotein Distribution of Clozapine
American Journal of Psychiatry
R. M. Procyshyn
DOI: 10.1176/appi.ajp.158.987.949
06/2001

Antipsychotic polypharmacy: a survey of discharge prescriptions from a tertiary care psychiatric institution.
Canadian journal of psychiatry. Revue canadienne de psychiatrie
Procyshyn RM and Kennedy NB and Tse G and Thompson B
DOI: 10.1177/070674370104600404
PubMed: 11387789
05/2001

Plasma protein and lipoprotein distribution of clozapine
American Journal of Psychiatry
Procyshyn, R.M. and Kennedy, N.B. and Marriage, S. and Wasan, K.M.
DOI: 10.1176/appi.ajp.158.6.949
2001

Discharge prescribing practices: Comparing a research ward to general treatment wards
International Journal of Psychiatry in Clinical Practice
Procyshyn, R.M. and Flynn, S.
DOI: 10.1080/136515001300375316
2001

New-onset diabetes mellitus associated with quetiapine.
Canadian journal of psychiatry. Revue canadienne de psychiatrie
Procyshyn RM and Pande S and Tse G
PubMed: 11056833
09/2000

Rational antipsychotic polypharmacy.
The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique
Kennedy NB and Procyshyn RM
PubMed: 11044761
01/2000

Pharmacoeconomics of clozapine, risperidone and olanzapine: A review of the literature
CNS Drugs
Procyshyn, R.M. and Thompson, D. and Tse, G.
DOI: 10.2165/00023210-200013010-00005
2000

Theoretical basis for loxapine augmentation in risperidone partial responders
Clinical Drug Investigation
Procyshyn, R.M. and Kennedy, N.B.
DOI: 10.2165/00044011-200019040-00003
2000

DR. Procyshyn replies
Clinical Therapeutics
Ric Procyshyn
DOI: 10.1016/s0149-2918(99)80064-2
05/1999

Valproic acid for seizure prophylaxis during clozapine therapy: Where's the evidence?
International Journal of Psychiatry in Clinical Practice
Balen, R.M. and Procyshyn, R.M.
DOI: 10.3109/13651509909068391
1999

Drug utilization patterns and outcomes associated with in-hospital treatment with risperidone or olanzapine.
Clinical therapeutics
Procyshyn RM and Zerjav S
DOI: 10.1016/s0149-2918(98)80116-1
PubMed: 9916613
11/1998

Engineering magnesium selectivity in the helix-loop-helix calcium-binding motif.
Archives of biochemistry and biophysics
Reid RE and Procyshyn RM
DOI: 10.1006/abbi.1995.0016
PubMed: 7487056
10/1995

A structure/activity study of calcium affinity and selectivity using a synthetic peptide model of the helix-loop-helix calcium-binding motif.
The Journal of biological chemistry
Procyshyn RM and Reid RE
PubMed: 8294410
01/1994

An examination of glutamic acid in the -X chelating position of the helix-loop-helix calcium binding motif
Archives of Biochemistry and Biophysics
Procyshyn, R.M. and Reid, R.E.
DOI: 10.1006/abbi.1994.1257
1994