Immune white cells, such as cytotoxic T lymphocytes (CTL) and natural killer (NK) cells, protect us from infectious diseases and cancer by killing infected or unwanted cells. Conversely, defects in the function or regulation of these cells can lead to immunodeficiency or autoimmunity. Currently we are studying the role of these cells in two diseases: type 1 diabetes and X-linked lymphoproliferative disease. In both these disorders, we have described defects in CTL and NK cells. By identifying these defects in detail we hope that we will be able to develop novel therapies for disease.


Profiling of circulating microRNAs in children with recent onset of type 1 diabetes
JCI Insight
Suheda Erener, Ashish Marwaha, Rusung Tan, Constadina Panagiotopoulos, Timothy J. Kieffer
DOI: 10.1172/jci.insight.89656

Pre-diagnostic genotyping identifies T1D subjects with impaired Treg IL-2 signaling and an elevated proportion of FOXP3+IL-17+ cells
Genes & Immunity
A K Marwaha, C Panagiotopoulos, C M Biggs, S Staiger, K L Del Bel, A F Hirschfeld, J J Priatel, S E Turvey, R Tan
DOI: 10.1038/gene.2016.44

Comparative evaluation of laboratory developed real-time PCR assays and RealStar® BKV PCR Kit for quantitative detection of BK polyomavirus
Journal of Virological Methods
Mohammad R. Hasan, Rusung Tan, Ghada Al-Rawahi, Eva Thomas, Peter Tilley
DOI: 10.1016/j.jviromet.2016.04.009

T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression
Journal of Clinical Investigation
Scott J. Patterson, Anne M. Pesenacker, Adele Y. Wang, Jana Gillies, Majid Mojibian, Kim Morishita, Rusung Tan, Timothy J. Kieffer, C. Bruce Verchere, Constadina Panagiotopoulos, Megan K. Levings
DOI: 10.1172/jci83987

Depletion of Human DNA in Spiked Clinical Specimens for Improvement of Sensitivity of Pathogen Detection by Next-Generation Sequencing
Journal of Clinical Microbiology
Mohammad R. Hasan, Arun Rawat, Patrick Tang, Puthen V. Jithesh, Eva Thomas, Rusung Tan, Peter Tilley
DOI: 10.1128/jcm.03050-15

CCL22 Prevents Rejection of Mouse Islet Allografts and Induces Donor-Specific Tolerance
Cell Transplantation
Joel Montane, Merce Obach, Sigrid Alvarez, Loraine Bischoff, Derek L. Dai, Galina Soukhatcheva, John J. Priatel, Gijs Hardenberg, Megan K. Levings, Rusung Tan, Paul C. Orban, C. Bruce Verchere
DOI: 10.3727/096368914x685249

Nocardia asteroides sinusitis in a pediatric patient: Case report with 20 year follow-up and review of the literature
International Journal of Pediatric Otorhinolaryngology
Brendan Sorichetti, Brian D. Westerberg, Rusung Tan, Frederick K. Kozak
DOI: 10.1016/j.ijporl.2015.04.022

CD1d Expression and Invariant NKT Cell Responses in Herpesvirus Infections
Frontiers in Immunology
Brian K. Chung, John J. Priatel, Rusung Tan
DOI: 10.3389/fimmu.2015.00312

Multiple sclerosis-associated CLEC16A controls HLA class II expression via late endosome biogenesis
Marvin M. van Luijn, Karim L. Kreft, Marlieke L. Jongsma, Steven W. Mes, Annet F. Wierenga-Wolf, Marjan van Meurs, Marie-José Melief, Rik van der Kant, Lennert Janssen, Hans Janssen, Rusung Tan, John J. Priatel, Jacques Neefjes, Jon D. Laman, Rogier Q. Hintzen
DOI: 10.1093/brain/awv080

SLAM–SAP Signaling Promotes Differentiation of IL-17–Producing T Cells and Progression of Experimental Autoimmune Encephalomyelitis
The Journal of Immunology
Yu-Hsuan Huang, Kevin Tsai, Caixia Ma, Bruce A. Vallance, John J. Priatel, Rusung Tan
DOI: 10.4049/jimmunol.1301435

Insulin-Producing Intestinal K Cells Protect Nonobese Diabetic Mice From Autoimmune Diabetes
Majid Mojibian, Ada W.Y. Lam, Yukihiro Fujita, Ali Asadi, Guntram A. Grassl, Peter Dickie, Rusung Tan, Anthony T. Cheung, Timothy J. Kieffer
DOI: 10.1053/j.gastro.2014.03.020

Combined immunodeficiency associated with homozygous MALT1 mutations
Journal of Allergy and Clinical Immunology
Margaret L. McKinnon, Jacob Rozmus, Shan-Yu Fung, Aaron F. Hirschfeld, Kate L. Del Bel, Leah Thomas, Nico Marr, Spencer D. Martin, Ashish K. Marwaha, John J. Priatel, Rusung Tan, Christof Senger, Angela Tsang, Julie Prendiville, Anne K. Junker, Michael Seear, Kirk R. Schultz, Laura M. Sly, Robert A. Holt, Millan S. Patel, Jan M. Friedman, Stuart E. Turvey
DOI: 10.1016/j.jaci.2013.10.045

Natural killer T cell strategies to combat Epstein–Barr virus infection
John J Priatel, Brian K Chung, Kevin Tsai, Rusung Tan
DOI: 10.4161/onci.28329

Evaluation of Amplification Targets for the Specific Detection ofBordetella pertussisUsing Real-Time Polymerase Chain Reaction
Canadian Journal of Infectious Diseases and Medical Microbiology
Mohammad Rubayet Hasan, Rusung Tan, Ghada N Al-Rawahi, Eva Thomas, Peter Tilley
DOI: 10.1155/2014/763128

Innate immune control of EBV-infected B cells by invariant natural killer T cells
B. K. Chung, K. Tsai, L. L. Allan, D. J. Zheng, J. C. Nie, C. M. Biggs, M. R. Hasan, F. K. Kozak, P. van den Elzen, J. J. Priatel, R. Tan
DOI: 10.1182/blood-2013-01-480665

Amino Acid Structure Determines the Immune Responses Generated by Peptide-Gold Nanoparticle Hybrids
Particle & Particle Systems Characterization
Hong Yang, Yingzhe Zhou, Shan-Yu Fung, Licun Wu, Kevin Tsai, Rusung Tan, Stuart E. Turvey, Tiago Machuca, Marc de Perrot, Thomas K. Waddell, Mingyao Liu
DOI: 10.1002/ppsc.201300213

Optimal Use of MRSASelect and PCR to Maximize Sensitivity and Specificity of MRSA Detection
Current Microbiology
Mohammad R. Hasan, John D. Brunstein, Ghada Al-Rawahi, Rusung Tan, Eva Thomas, Peter Tilley
DOI: 10.1007/s00284-012-0241-1

Short-Term Stability of Pathogen-Specific Nucleic Acid Targets in Clinical Samples
Journal of Clinical Microbiology
M. R. Hasan, R. Tan, G. N. Al-Rawahi, E. Thomas, P. Tilley
DOI: 10.1128/jcm.02659-12

PP065. dNK and dNK-CM mediated alterations of DNA methylation in extravillous cytotrophoblasts (EVTS)
Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health
Y. Hu and R. Yuen and G. Eastabrook and J. Dutz and R. Tan and P. von Dadelszen and W. Robinson
DOI: 10.1016/j.preghy.2012.04.176

Decidual NK Cell-Derived Conditioned Medium (dNK-CM) Mediates VEGF-C Secretion in Extravillous CytotrophoblastsDNK-CM MEDIATES VEGF-C SECRETION IN EVT
American Journal of Reproductive Immunology
Genevieve D. M. Eastabrook, Yuxiang Hu, Rusung Tan, Jan P. Dutz, Colin D. MacCalman, Peter von Dadelszen
DOI: 10.1111/j.1600-0897.2011.01075.x

The CaV1.4 Calcium Channel Is a Critical Regulator of T Cell Receptor Signaling and Naive T Cell Homeostasis
Kyla Omilusik, John J. Priatel, Xiaoxi Chen, Yiwen Teresa Wang, Hongjian Xu, Kyung Bok Choi, Rayshad Gopaul, Adam McIntyre-Smith, Hung-Sia Teh, Rusung Tan, N. Torben Bech-Hansen, Douglas Waterfield, David Fedida, Simon V. Hunt, Wilfred A. Jefferies
DOI: 10.1016/j.immuni.2011.07.011

NKT Cells Are Required for Complete Freund's Adjuvant-Mediated Protection from Autoimmune Diabetes
The Journal of Immunology
I.-F. Lee, P. van den Elzen, R. Tan, J. J. Priatel
DOI: 10.4049/jimmunol.1002551

Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets
Journal of Clinical Investigation
Joel Montane, Loraine Bischoff, Galina Soukhatcheva, Derek L. Dai, Gijs Hardenberg, Megan K. Levings, Paul C. Orban, Timothy J. Kieffer, Rusung Tan, C. Bruce Verchere
DOI: 10.1172/jci43048

The central repeat domain 1 of Kaposi's sarcoma-associated herpesvirus (KSHV) latency associated-nuclear antigen 1 (LANA1) prevents cis MHC class I peptide presentation
Hyun Jin Kwun, Suzane Ramos da Silva, Huilian Qin, Robert L. Ferris, Rusung Tan, Yuan Chang, Patrick S. Moore
DOI: 10.1016/j.virol.2011.01.026

CD1d and CD1c Expression in Human B Cells Is Regulated by Activation and Retinoic Acid Receptor Signaling
The Journal of Immunology
L. L. Allan, A. M. Stax, D.-J. Zheng, B. K. Chung, F. K. Kozak, R. Tan, P. van den Elzen
DOI: 10.4049/jimmunol.1003615

Natural Killer Cells From Children With Type 1 Diabetes Have Defects in NKG2D-Dependent Function and Signaling
Huilian Qin, I-Fang Lee, Constadina Panagiotopoulos, Xiaoxia Wang, Alvina D. Chu, Paul J. Utz, John J. Priatel, Rusung Tan
DOI: 10.2337/db09-1706

Cutting Edge: Increased IL-17-Secreting T Cells in Children with New-Onset Type 1 Diabetes
The Journal of Immunology
A. K. Marwaha, S. Q. Crome, C. Panagiotopoulos, K. B. Berg, H. Qin, Q. Ouyang, L. Xu, J. J. Priatel, M. K. Levings, R. Tan
DOI: 10.4049/jimmunol.1001860

Decidual NK cell-derived conditioned medium enhances capillary tube and network organization in an extravillous cytotrophoblast cell line
Y. Hu and G. Eastabrook and R. Tan and C.D. MacCalman and J.P. Dutz and P. von Dadelszen
DOI: 10.1016/j.placenta.2009.12.011

Apolipoprotein-mediated lipid antigen presentation in B cells provides a pathway for innate help by NKT cells
L. L. Allan, K. Hoefl, D.-J. Zheng, B. K. Chung, F. K. Kozak, R. Tan, P. van den Elzen
DOI: 10.1182/blood-2009-04-211417

Optimizing outcomes of hematopoietic stem cell transplantation for severe combined immunodeficiency
Clinical Immunology
Geoff D.E. Cuvelier, Kirk R. Schultz, Jeff Davis, Aaron F. Hirschfeld, Anne K. Junker, Rusung Tan, Stuart E. Turvey
DOI: 10.1016/j.clim.2009.01.003

RasGRP1 Regulates Antigen-Induced Developmental Programming by Naive CD8 T Cells
The Journal of Immunology
J. J. Priatel, X. Chen, Y.-H. Huang, M. T. Chow, L. A. Zenewicz, J. J. Coughlin, H. Shen, J. C. Stone, R. Tan, H. S. Teh
DOI: 10.4049/jimmunol.0803521

The X-linked lymphoproliferative syndrome gene product SAP regulates B cell function through the Fc¿RIIB receptor
Cellular Signalling
Chengjun Li, Brian Chung, Jianping Tao, Cristiana Iosef, Ala Aoukaty, Yefu Wang, Rusung Tan, Shawn Shun-Cheng Li
DOI: 10.1016/j.cellsig.2008.07.004

IFN- -mediated extravillous trophoblast outgrowth inhibition in first trimester explant culture: a role for insulin-like growth factors
Molecular Human Reproduction
Y. Hu, R. Tan, C. D. MacCalman, G. Eastabrook, S.-H. Park, J. P. Dutz, P. von Dadelszen
DOI: 10.1093/molehr/gan018

Critical role for IFN-¿ in natural killer cell-mediated protection from diabetes
European Journal of Immunology
I-Fang Lee, Huilian Qin, John J. Priatel, Rusung Tan
DOI: 10.1002/eji.200737189

Xenogeneic  2-Microglobulin Substitution Affects Functional Binding of MHC Class I Molecules by CD8+ T Cells
The Journal of Immunology
L. A. Benoit, R. Tan
DOI: 10.4049/jimmunol.179.6.3588

Xenogeneic  2-Microglobulin Substitution Alters NK Cell Function
The Journal of Immunology
L. A. Benoit, R. Tan
DOI: 10.4049/jimmunol.179.3.1466

Prospective prediction of spontaneous but not recurrent autoimmune diabetes in the non-obese diabetic mouse
J. D. Trudeau, T. Chandler, G. Soukhatcheva, C. B. Verchere, R. Tan
DOI: 10.1007/s00125-007-0600-9

Identification of Novel HLA-A*0201-Restricted Epitopes in Recent-Onset Type 1 Diabetic Subjects and Antibody-Positive Relatives
N. E. Standifer, Q. Ouyang, C. Panagiotopoulos, C. B. Verchere, R. Tan, C. J. Greenbaum, C. Pihoker, G. T. Nepom
DOI: 10.2337/db06-0066

Recognition of HLA Class I-Restricted  -Cell Epitopes in Type 1 Diabetes
Q. Ouyang, N. E. Standifer, H. Qin, P. Gottlieb, C. B. Verchere, G. T. Nepom, R. Tan, C. Panagiotopoulos
DOI: 10.2337/db06-0065

Decidual NK Cells Alter In Vitro First Trimester Extravillous Cytotrophoblast Migration: A Role for IFN- 
The Journal of Immunology
Y. Hu, J. P. Dutz, C. D. MacCalman, P. Yong, R. Tan, P. von Dadelszen
DOI: 10.4049/jimmunol.177.12.8522

Murine CD160, Ig-Like Receptor on NK Cells and NKT Cells, Recognizes Classical and Nonclassical MHC Class I and Regulates NK Cell Activation
The Journal of Immunology
M. Maeda, C. Carpenito, R. C. Russell, J. Dasanjh, L. L. Veinotte, H. Ohta, T. Yamamura, R. Tan, F. Takei
DOI: 10.4049/jimmunol.175.7.4426

The X-Linked Inhibitor of Apoptosis Protein Enhances Survival of Murine Islet Allografts
A. Plesner, P. Liston, R. Tan, R. G. Korneluk, C. B. Verchere
DOI: 10.2337/diabetes.54.9.2533

Role for Glycogen Synthase Kinase-3 in NK Cell Cytotoxicity and X-Linked Lymphoproliferative Disease
The Journal of Immunology
A. Aoukaty, R. Tan
DOI: 10.4049/jimmunol.174.8.4551

Cutting Edge: Signaling Lymphocytic Activation Molecule-Associated Protein Controls NKT Cell Functions
The Journal of Immunology
B. Chung, A. Aoukaty, J. Dutz, C. Terhorst, R. Tan
DOI: 10.4049/jimmunol.174.6.3153

Rapid and Fatal Meningococcal Disease Due to a Strain of Neisseria meningitidis Containing the Capsule Null Locus
Clinical Infectious Diseases
L. M. N. Hoang, E. Thomas, S. Tyler, A. J. Pollard, G. Stephens, L. Gustafson, A. McNabb, I. Pocock, R. Tsang, R. Tan
DOI: 10.1086/427875

Current approaches for the prediction and identification of CD8 T cell epitopes in type 1 diabetes
Current Opinion in Endocrinology and Diabetes
DOI: 10.1097/01.med.0000169384.05495.20

Progression of spontaneous autoimmune diabetes is associated with a switch in the killing mechanism used by autoreactive CTL
International Immunology
H. Qin
DOI: 10.1093/intimm/dxh167

Molecular Dissection of 2B4 Signaling: Implications for Signal Transduction by SLAM-Related Receptors
Molecular and Cellular Biology
R. Chen, F. Relouzat, R. Roncagalli, A. Aoukaty, R. Tan, S. Latour, A. Veillette
DOI: 10.1128/mcb.24.12.5144-5156.2004

T-cell epitopes in type 1 diabetes
Current Diabetes Reports
Constadina Panagiotopoulos, Jacqueline D. Trudeau, Rusung Tan
DOI: 10.1007/s11892-004-0062-0

Detection and Genotyping of Varicella-Zoster Virus by TaqMan Allelic Discrimination Real-Time PCR
Journal of Clinical Microbiology
P. A. Campsall, N. H. C. Au, J. S. Prendiville, D. P. Speert, R. Tan, E. E. Thomas
DOI: 10.1128/jcm.42.4.1409-1413.2004

Regulation of Autoimmune Diabetes by Complete Freund's Adjuvant Is Mediated by NK Cells
The Journal of Immunology
I.-F. Lee, H. Qin, J. Trudeau, J. Dutz, R. Tan
DOI: 10.4049/jimmunol.172.2.937

Identification of a Beta-Cell-Specific HLA Class I Restricted Epitope in Type 1 Diabetes
C. Panagiotopoulos and H. Qin and R. Tan and C. B. Verchere
DOI: 10.2337/diabetes.52.11.2647

Optimization of epicutaneous immunization for the induction of CTL
Roopjeet Kahlon, Yuxiang Hu, Catherine H. Orteu, Arnawaz Kifayet, Jacqueline D. Trudeau, Rusung Tan, Jan P. Dutz
DOI: 10.1016/s0264-410x(03)00141-5

Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood
Journal of Clinical Investigation
Jacqueline D. Trudeau, Carolyn Kelly-Smith, C. Bruce Verchere, John F. Elliott, Jan P. Dutz, Diane T. Finegood, Pere Santamaria, Rusung Tan
DOI: 10.1172/jci200316409

Chronic Active Epstein--Barr Virus Infection Associated with Low Expression of Leukocyte-Associated Immunoglobulin-Like Receptor-1 (LAIR-1) on Natural Killer Cells
Journal of Clinical Immunology
author= {Aoukaty, Ala and Lee, I-Fang and Wu, John and Tan, Rusung}
DOI: 10.1023/A:1022580929226

Preventing tropical illness in elderly travellers: the older cruiser
Geriatrics and Aging

In Situ   Cell Death Promotes Priming of Diabetogenic CD8 T Lymphocytes
The Journal of Immunology
Y. Zhang, B. O'Brien, J. Trudeau, R. Tan, P. Santamaria, J. P. Dutz
DOI: 10.4049/jimmunol.168.3.1466

Establishment and comprehensive analysis of a new human transformed follicular lymphoma B cell line, Tat-1
T Denyssevych, V S Lestou, S Knesevich, M Robichaud, C Salski, R Tan, R D Gascoyne, D E Horsman, L D Mayer
DOI: 10.1038/sj.leu.2402372

Association of the X-linked Lymphoproliferative Disease Gene Product SAP/SH2D1A with 2B4, a Natural Killer Cell-activating Molecule, Is Dependent on Phosphoinositide 3-Kinase
Journal of Biological Chemistry
Ala Aoukaty, Rusung Tan
DOI: 10.1074/jbc.m112029200

Expansion of the Antigenic Repertoire of a Single T Cell Receptor upon T Cell Activation
The Journal of Immunology
A. Amrani, P. Serra, J. Yamanouchi, J. D. Trudeau, R. Tan, J. F. Elliott, P. Santamaria
DOI: 10.4049/jimmunol.167.2.655

Utilization of herpes simplex PCR assays for cerebrospinal fluid in a pediatric health care setting
Canadian Journal of Microbiology
Nevio Cimolai, Eva E Thomas, Rusung Tan, Alan Hill
DOI: 10.1139/w01-028

Lymphocytic vasculitis in X-linked lymphoproliferative disease
J. P. Dutz
DOI: 10.1182/blood.v97.1.95

The expanding clinical phenotype of SAP/SH2D1A mutations

Meningococcal Disease in British Columbia
BC Medical Journal

Cutting Edge: Defective NK Cell Activation in X-Linked Lymphoproliferative Disease
The Journal of Immunology
L. Benoit, X. Wang, H. F. Pabst, J. Dutz, R. Tan
DOI: 10.4049/jimmunol.165.7.3549

Creating HIV-1 reverse transcriptase cytotoxic T lymphocyte target structures by HLA-A2 heavy chain modifications
International Immunology
Charles S. Dela Cruz, Rusung Tan, Sarah L. Rowland-Jones, Brian H. Barber
DOI: 10.1093/intimm/12.9.1293

Progression of autoimmune diabetes driven by avidity maturation of a T-cell population
Abdelaziz Amrani, Joan Verdaguer, Pau Serra, Sabrina Tafuro, Rusung Tan, Pere Santamaria
DOI: 10.1038/35021081

Expansion of human cytotoxic T lymphocytes for immunotherapy
Lymphocytes: A Practical Approach (2nd edition)

Rapid Death of Adoptively Transferred T Cells in Acquired Immunodeficiency Syndrome
Tan, Rusung and Xu, Xiaoning and Ogg, Graham S. and Hansasuta, Pokrath and Dong, Tao and Rostron, Tim and Luzzi, Graz and Conlon, Christopher P. and Screaton, Gavin R. and McMichael, Andrew J. and Rowland-Jones, Sarah

Antigen–specific release of ß-chemokines by anti-HIV-1 cytotoxic T lymphocytes
Current Biology
David A. Price, Andrew K. Sewell, Tao Dong, Rusung Tan, Philip J.R. Goulder, Sarah L. Rowland-Jones, Rodney E. Phillips
DOI: 10.1016/s0960-9822(98)70138-1

Case-Control Study of Primary Human Herpesvirus 6 Infection in Children With Febrile Seizures
J. Hukin, K. Farrell, L. M MacWilliam, M. Colbourne, E. Waida, R. Tan, L. Mroz, E. Thomas
DOI: 10.1542/peds.101.2.e3

Immunogenicities of intravenous and intramuscular administrations of modified vaccinia virus Ankara-based multi-CTL epitope vaccine for human immunodeficiency virus type 1 in mice.
Journal of General Virology
T Hanke, R Tan, A McMichael, A V Hill, M Becker, T J Blanchard, G L Smith, G S Ogg, J Schneider, S C Gilbert
DOI: 10.1099/0022-1317-79-1-83

Prolonged CD8+ T-cell expansions after adoptive transfer of syngeneic lymphocytes to a patient with AIDS
PubMed: 9833875

Control of HIV co-receptor expression: Implications for pathogenesis and treatment
Trends in Microbiology
Sarah Rowland-Jones, Rusung Tan
DOI: 10.1016/s0966-842x(97)01092-5

Immunology of HIV infection
Molecular Medicine Today
Rusung Tan
DOI: 10.1016/s1357-4310(97)01063-0

Evasion of Cytotoxic T Lymphocyte (CTL) Responses byNef-dependent Induction of Fas Ligand (CD95L) Expression on Simian Immunodeficiency Virus–infected Cells
The Journal of Experimental Medicine
Xiao-Ning Xu, Gavin R. Screaton, Frances M. Gotch, Tao Dong, Rusung Tan, Neil Almond, Barry Walker, Richard Stebbings, Karen Kent, Shigekazu Nagata, Jim E. Stott, Andrew J. McMichael
DOI: 10.1084/jem.186.1.7

LARD: A new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing
Proceedings of the National Academy of Sciences
G. R. Screaton, X.-N. Xu, A. L. Olsen, A. E. Cowper, R. Tan, A. J. McMichael, J. I. Bell
DOI: 10.1073/pnas.94.9.4615

Role of Cellular Immunity in Protection against HIV Infection
Advances in Immunology
Sarah Rowland-Jones and Rusung Tan and Andrew McMichael
DOI: 10.1016/s0065-2776(08)60745-2

Postoperative Endophthalmitis Caused by Stomatococcus mucilaginosus
Clinical Infectious Diseases
R. Tan, V. White, G. Servais, E. A. Bryce
DOI: 10.1093/clinids/18.3.492

The Four "I’s"Letter
Journal of Travel Medicine

Immunizations for travel to tropical and developing countries
BC Medical Journal

Sharps utilization and disposal in British Columbia physicians’ offices
Canadian Journal of Public Health
PubMed: 8500054

Guidelines for HIV screening
BC Medical Journal

B7 costimulates proliferation of CD4-8+ T lymphocytes but is not required for the deletion of immature CD4+8+ thymocytes.
The Journal of Immunology
Tan, R and Teh, S J and Ledbetter, J A and Linsley, P S and Teh, H S


Medical microbiology, virology and infection control (clinical)
The medical microbiology laboratory in the Department of Pathology & Laboratory Medicine at BC Children's Hospital (BCCH) is a leader in the development of molecular diagnostic assays for pediatric infectious diseases. For example, molecular assays have been developed for human herpesvirus 6 (HHV-6), enteroviruses and Epstein-Barr virus, for the diagnosis and typing of Neisseria meningitidis (meningococcus) and for novel agents such as human metapneumovirus. The laboratory is continually adapting and developing new real-time (Taqman) and rapid Smart Cycler PCR diagnostics for a variety of bacterial and viral pathogens. In addition the laboratory is engaged in changing the primary care management of common respiratory illnesses by providing a VIral RAPid testing program (VIRAP) that allows for the rapid (

Autoimmunity in type 1 diabetes
Type 1 (juvenile-onset) diabetes mellitus arises from a T-cell-mediated autoimmune process directed against pancreatic beta cells in both humans and non-obese diabetic (NOD) mice. The destruction of beta cells is mediated by CD8+ cytotoxic T lymphocytes (CTL). Using MHC Class 1 tetrameric complexes to detect and determine the frequency of autoreactive CTL in NOD mice we have developed a predictive algorithm for disease. In collaboration with Drs. Bruce Verchere and Dina Panagiotopoulos we are hoping to extend these findings to humans through the identification of human MHC class I restricted epitopes. The laboratory is also studying several different areas of the pathogenesis of type 1 diabetes including the role of autoreactive CTL and the role of natural killer cells.

X-linked lymphoproliferative disease
We have cloned and sequenced a novel mutation in the gene responsible for the fatal childhood disease, X-linked lymphoproliferative disease (XLP), thus resolving a longstanding mystery of unexplained male deaths in a large aboriginal family from northern Canada. The presence of the mutation in this extended family allows us to study the specific role of the lymphocyte cell protein, SLAM-associated protein (SAP) in human immunity to viruses and tumours. In particular, we are investigating the role of SAP in the cellular and molecular dysfunction of cytotoxic T lymphocytes and natural killer cells and the relationship between these abnormalities and the clinical phenotype of disease.

Honours & Awards

Most Valuable Player, Department of Pathology & Laboratory Medicine, University of British Columbia - 2009

Michael Smith Foundation Senior Scholar 2006-

Green College Faculty Member, 2005-