Sally Lawrence

MBChB, FRCPCH, FRCPC Affiliate

Investigator and Pediatric Gastroenterologist, BC Children's Hospital
Clinical Director, Pediatric IBD Program

There is increasing evidence to suggest diet plays an important role in inflammatory bowel disease by impacting the gut microbiome and affecting the barrier function of the gut (protective mucus layer and intestinal epithelial tight junctions). In our studies we are looking at the role of various diets and the impact they have on the clinical outcome and quality of life for our patients. We are also assessing the impact diet therapies have on the gut microbiome and immune regulation receptor pathways within the body.

We have also been assessing the immune response to vaccinations in patients with IBD on immunosuppression therapy.

Academic Affiliations

  • Clinical Assistant Professor, Division of Gastroenterology, Hepatology & Nutrition, Department of Pediatrics, Faculty of Medicine, University of British Columbia
  • Research Theme: Childhood Diseases
  • Research Group(s): Clinical Practice, Outcomes and Innovation; Immunity in Health and Disease; Mental Health and Behaviour; Origins of Child Health and Disease; Vaccines, Infections, and Host Defenses

Contact Information

Location

4480 Oak Street, Vancouver, British Columbia, Canada, V6H 3V4

Durability of Antibody Responses to SARS-CoV-2 Vaccination over 12 Months in Pediatric Inflammatory Bowel Disease

Vaccines

Lawrence, S.J. and Vi{\~n}eta Paramo, M. and Reicherz, F. and Bone, J.N. and Shire, Z.J.H. and Bilal, L. and Guerra, G. and Golding, L. and Lavoie, P.M. and Jacobson, K.

DOI: 10.3390/vaccines13060549

Modified Crohn's Disease Exclusion Diet Maintains Remission in Pediatric Crohn's Disease: Randomized Controlled Trial

Clinical Gastroenterology and Hepatology

Sigall Boneh, R. and Navas-L{\'o}pez, V.M. and Hussey, S. and Pujol-Muncunill, G. and Lawrence, S. and Rolandsdotter, H. and Otley, A. and Mart{\'i}n-de-Carpi, J. and Abramas, L. and Herrador-L{\'o}pez, M. and Egea Castillo, N. and Chen, M. and Hurley, M. and Wingate, K. and Olen, O. and Eurenius R{\"a}{\"a}f, T. and Yaakov, M. and Wierdsma, N. and Van Limbergen, J. and Wine, E.

DOI: 10.1016/j.cgh.2024.12.006

Perspectives of Adolescents and Young Adults With Inflammatory Bowel Disease on a Biopsychosocial Transition Intervention: Qualitative Interview Study

Jmir Pediatrics and Parenting

Allemang, B. and Miatello, A. and Browne, M. and Barwick, M. and Maini, P. and Eszczuk, J. and Pandit, C. and Sadhra, T. and Forhan, L. and Bollegala, N. and Fu, N. and Lee, K. and Dekker, E. and Nistor, I. and Kohut, S.A. and Keefer, L. and Griffiths, A.M. and Walters, T.D. and Micsinszki, S. and Mack, D.R. and Lawrence, S. and Kroeker, K.I. and de Guzman, J. and Tausif, A. and Tersigni, C. and Anthony, S.J. and Benchimol, E.I.

DOI: 10.2196/64618

Adalimumab vs Infliximab in Luminal Pediatric Crohn's Disease: Comparable Outcomes in a Prospective Multicenter Cohort Study

American Journal of Gastroenterology

Jennifer C. deBruyn and Hien Q. Huynh and Anne M. Griffiths and Kevan Jacobson and David Mack and Colette Deslandres and Wael El-Matary and Anthony R. Otley and Peter C. Church and Sally Lawrence and Eytan Wine and Mary Sherlock and Jeffrey Critch and Eric I. Benchimol and Prvost Jantchou and Mohsin Rashid and Matthew W. Carroll and Kevin Bax and Amanda Ricciuto and Nicholas Carman and Thomas D. Walters

DOI: 10.14309/ajg.0000000000002552

03 / 2024

Expanding the molecular and phenotypic spectrum of CTLA-4 insufficiency

Pediatric Allergy and Immunology

Duke, S. and Maiarana, J. and Yousefi, P. and Burks, E. and Gerrie, S. and Setiadi, A. and Amid, A. and Boerkel, C. and Erdle, S. and Guttman, O. and Kanani, A. and Lawrence, S. and Lee, A.F. and Pourshahnazari, P. and Rayar, M. and Rozmus, J. and Schrader, D. and Sharma, M. and Shopsowitz, K.E. and Tan, R. and To, F. and Yang, C. and Hildebrand, K.J. and James, E. and Turvey, S.E. and Markle, J.G. and Biggs, C.M.

DOI: 10.1111/pai.14077

Response from the Canadian Children Inflammatory Bowel Disease Network to the US Food and Drug Administration Draft Guidance for Industry on pediatric inflammatory bowel disease: developing drugs for treatment

Journal of the Canadian Association of Gastroenterology

Wine, E. and Debruyn, J. and Crowley, E. and Griffiths, A.M. and Jeong, J. and Jacobson, K. and Lawrence, S. and Piper, H. and Smyth, M. and Tropini, C. and Vallance, B. and de Bruyn, J. and Huynh, H. and Carroll, M. and Isaac, D.M. and Armstrong, H. and El-Matary, W. and Grover, Z. and Bax, K. and Brill, H. and Dowhaniuk, J. and Prowse, K. and Sherlock, M. and Zachos, M. and Hart, L. and Popalis, C. and Griffths, A.M. and Muise, A. and Ricciuto, A. and Benchimol, E. and Jones, N. and Carman, N. and Church, P. and Walters, T. and Mulder, D. and Mack, D. and Stanisz, J. and Stintzi, A. and Pai, N. and Deslandres, C. and Breton, J. and Grzywacz, K. and Jantchou, P. and Chapuy, L. and Schneider, R. and Otley, A. and Burnett, D. and Critch, J. and Dinn, S.

DOI: 10.1093/jcag/gwae034

Outcomes Following Acute Severe Colitis at Initial Presentation: A Multi-centre, Prospective, Paediatric Cohort Study

Journal of Crohn's and Colitis

Dhaliwal, J. and Tertigas, D. and Carman, N. and Lawrence, S. and Debruyn, J.C. and Wine, E. and Church, P.C. and Huynh, H.Q. and Rashid, M. and El-Matary, W. and Deslandres, C. and Critch, J. and Ricciuto, A. and Carroll, M.W. and Benchimol, E.I. and Muise, A. and Jacobson, K. and Otley, A.R. and Vallance, B. and Mack, D.R. and Walters, T.D. and Surette, M.G. and Griffiths, A.M.

DOI: 10.1093/ecco-jcc/jjad143

Landscape of TPMT and NUDT15 Pharmacogenetic Variation in a Cohort of Canadian Pediatric Inflammatory Bowel Disease Patients

Inflammatory Bowel Diseases

Kennedy, A.M. and Griffiths, A.M. and Muise, A.M. and Walters, T.D. and Ricciuto, A. and Huynh, H.Q. and Wine, E. and Jacobson, K. and Lawrence, S. and Carman, N. and Mack, D.R. and deBruyn, J.C. and Otley, A.R. and Deslandres, C. and El-Matary, W. and Zachos, M. and Benchimol, E.I. and Critch, J. and Schneider, R. and Crowley, E. and Li, M. and Warner, N. and McGovern, D.P.B. and Li, D. and Haritunians, T. and Rudin, S. and Cohn, I.

DOI: 10.1093/ibd/izae109

Mental Health Experiences of Adolescents and Young Adults with Inflammatory Bowel Disease During Transition to Adult Care: A Qualitative Descriptive Study

Journal of Pediatrics

Allemang, B. and Browne, M. and Barwick, M. and Bollegala, N. and Fu, N. and Lee, K. and Miatello, A. and Dekker, E. and Nistor, I. and Ahola Kohut, S. and Keefer, L. and Micsinszki, S. and Walters, T.D. and Griffiths, A.M. and Mack, D.R. and Lawrence, S. and Kroeker, K.I. and de Guzman, J. and Tausif, A. and Maini, P. and Tersigni, C. and Anthony, S.J. and Benchimol, E.I.

DOI: 10.1016/j.jpeds.2024.114123

Inflammatory Bowel Disease Among Canadian Children: Comparison Between Children of Non-European Descent and Children of European Descent

Inflammatory Bowel Diseases

Jeong, J. and Walters, T.D. and Huynh, H.Q. and Lawrence, S. and Mack, D.R. and Deslandres, C. and Otley, A. and El-Matary, W. and Sherlock, M. and Griffiths, A.M. and Wine, E. and Jacobson, K. and Church, P. and Carroll, M.W. and Benchimol, E.I. and Brill, H. and Critch, J. and Bax, K. and Jantchou, P. and Rashid, M. and Kaplan, G.G. and Seow, C.H. and Novak, K. and deBruyn, J.C.

DOI: 10.1093/ibd/izac276

Transition Readiness in Youth with Inflammatory Bowel Disease

Journal of Pediatrics

Foster, A. and Chan, J.M. and Wine, E. and El-Matary, W. and Carroll, M.W. and Kroeker, K.I. and deBruyn, J.C. and Seow, C.H. and Lawrence, S. and Evans, K. and Kluthe, C. and Sharifi, N. and Pears, C. and Nicol, S. and Olayinka, L. and Fu, N. and Huynh, H.Q. and Bressler, B. and Bernstein, C.N. and Jacobson, K.

DOI: 10.1016/j.jpeds.2023.113403

Progression to Anti-TNF Treatment in Very Early Onset Inflammatory Bowel Disease Patients

Journal of Pediatric Gastroenterology and Nutrition

Eindor-Abarbanel, A. and Meleady, L. and Lawrence, S. and Hamilton, Z. and Krikler, G. and Lakhani, A. and Zhang, Q. and Jacobson, K.

DOI: 10.1097/MPG.0000000000003551

Antibody response to the BNT162b2 SARS-CoV-2 vaccine in paediatric patients with inflammatory bowel disease treated with anti-TNF therapy

Gut

Shire, Z.J. and Reicherz, F. and Lawrence, S. and Sudan, H. and Golding, L. and Majdoubi, A. and Levett, P.N. and Lavoie, P.M. and Jacobson, K.

DOI: 10.1136/gutjnl-2021-326196

Optimized Infliximab Induction Predicts Better Long-Term Clinical and Biomarker Outcomes Compared to Standard Induction Dosing

Journal of Pediatric Gastroenterology and Nutrition

Lawrence, S. and Faytrouni, F. and Harris, R.E. and Irvine, M. and Carrion, E. and Scott, G. and Clarke, B. and Garrick, V. and Curtis, L. and Gervais, L. and Tayler, R. and Riou, M. and Hansen, R. and Jacobson, K. and Russell, R.K.

DOI: 10.1097/MPG.0000000000003587

Multimodal intervention to improve the transition of patients with inflammatory bowel disease from pediatric to adult care: protocol for a randomized controlled trial

BMC Gastroenterology

Bollegala, N. and Barwick, M. and Fu, N. and Griffiths, A.M. and Keefer, L. and Kohut, S.A. and Kroeker, K.I. and Lawrence, S. and Lee, K. and Mack, D.R. and Walters, T.D. and de Guzman, J. and Tersigni, C. and Miatello, A. and Benchimol, E.I.

DOI: 10.1186/s12876-022-02307-9

All hands on deck: A multidisciplinary approach to SARS-CoV-2-associated MIS-C

Paediatrics and Child Health (Canada)

Lopez, A.A. and Patel, M. and Rayment, J.H. and Tam, H. and Roberts, A. and Laskin, S. and Tucker, L. and Biggs, C.M. and Ahmed, M.A. and Barakauskas, V. and Galanis, E. and Goldfarb, D. and Halparin, J. and Harris, K.C. and Kissoon, N. and Lawrence, S. and McGuffin, D. and Meckler, G. and Noel, K. and Schrader, D. and Sherwood, M. and Singh, A. and Vercauteren, S.

DOI: 10.1093/pch/pxab110

The Phenotypic Spectrum of New-onset IBD in Canadian Children of South Asian Ethnicity: A Prospective Multi-Centre Comparative Study

Journal of Crohn's and Colitis

Dhaliwal, J. and Carroll, M.W. and Debruyn, J.C. and Ricciuto, A. and Benchimol, E.I. and Lawrence, S. and Sherlock, M. and El-Matary, W. and Brill, H. and Church, P. and Wine, E. and Carman, N. and Muise, A. and Huynh, H. and Mack, D.R. and Walters, T.D. and Griffiths, A.M. and Jacobson, K.

DOI: 10.1093/ecco-jcc/jjab143

All hands on deck: A multidisciplinary approach to SARS-CoV-2-associated MIS-C,Tout le monde sur le pont: une approche multidisciplinaire du SRAS-CoV-2 associe au SIME

Paediatrics and Child Health (Canada)

Lopez, A.A. and Patel, M. and Rayment, J.H. and Tam, H. and Roberts, A. and Laskin, S. and Ahmed, M.A. and Barakauskas, V. and Galanis, E. and Goldfarb, D. and Halparin, J. and Harris, K.C. and Kissoon, N. and Lawrence, S. and Mcguffin, D. and Meckler, G. and Noel, K. and Schrader, D. and Sherwood, M. and Singh, A. and Vercauteren, S. and Tucker, L. and Biggs, C.M.

DOI: 10.1093/pch/pxac018

Diagnostic Delay Is Associated with Complicated Disease and Growth Impairment in Paediatric Crohn's Disease

Journal of Crohn's and Colitis

Ricciuto, A. and Mack, D.R. and Huynh, H.Q. and Jacobson, K. and Otley, A.R. and Debruyn, J. and El-Matary, W. and Deslandres, C. and Sherlock, M.E. and Critch, J.N. and Bax, K. and Jantchou, P. and Seidman, E.G. and Carman, N. and Rashid, M. and Muise, A. and Wine, E. and Carroll, M.W. and Lawrence, S. and Van Limbergen, J. and Benchimol, E.I. and Walters, T.D. and Griffiths, A.M. and Church, P.C.

DOI: 10.1093/ecco-jcc/jjaa197

Discontinuation of Immunosuppressive Medications in Children with Inflammatory Bowel Disease on Combination Therapy

Journal of Pediatric Gastroenterology and Nutrition

El-Matary, W. and Carroll, M.W. and Debruyn, J.C. and Huynh, H. and Wine, E. and Lawrence, S. and Chandrakumar, A. and Morel, T. and Jacobson, K.

DOI: 10.1097/MPG.0000000000002857

High body mass index is not associated with increased treatment failure in infliximab treated pediatric patients with inflammatory bowel disease

JGH Open

Rodin, I. and Chan, J. and Meleady, L. and Hii, C. and Lawrence, S. and Jacobson, K.

DOI: 10.1002/jgh3.12277

Phenotypic Variation in Paediatric Inflammatory Bowel Disease by Age: A Multicentre Prospective Inception Cohort Study of the Canadian Children IBD Network

Journal of Crohn's and Colitis

Dhaliwal, J. and Walters, T.D. and Mack, D.R. and Huynh, H.Q. and Jacobson, K. and Otley, A.R. and Debruyn, J. and El-Matary, W. and Deslandres, C. and Sherlock, M.E. and Critch, J.N. and Bax, K. and Seidman, E. and Jantchou, P. and Ricciuto, A. and Rashid, M. and Muise, A.M. and Wine, E. and Carroll, M. and Lawrence, S. and Van Limbergen, J. and Benchimol, E.I. and Church, P. and Griffiths, A.M.

DOI: 10.1093/ecco-jcc/jjz106

Canadian Association of Gastroenterology Clinical Practice Guideline for the Medical Management of Pediatric Luminal Crohn's Disease

Gastroenterology

Mack, D.R. and Benchimol, E.I. and Critch, J. and deBruyn, J. and Tse, F. and Moayyedi, P. and Church, P. and Deslandres, C. and El-Matary, W. and Huynh, H. and Jantchou, P. and Lawrence, S. and Otley, A. and Sherlock, M. and Walters, T. and Kappelman, M.D. and Sadowski, D. and Marshall, J.K. and Griffiths, A.

DOI: 10.1053/j.gastro.2019.03.022

Management of Paediatric Patients with Medically Refractory Crohn's Disease Using Ustekinumab: A Multi-Centred Cohort Study

Journal of Crohn's and Colitis

Chavannes, M. and Martinez-Vinson, C. and Hart, L. and Kaniki, N. and Chao, C.-Y. and Lawrence, S. and Jacobson, K. and Hugot, J.-P. and Viala, J. and Deslandres, C. and Jantchou, P. and Seidman, E.G.

DOI: 10.1093/ecco-jcc/jjy206

Higher postinduction infliximab serum trough levels are associated with healing of fistulizing perianal Crohn's disease in children

Inflammatory Bowel Diseases

El-Matary, W. and Walters, T.D. and Huynh, H.Q. and Debruyn, J. and MacK, D.R. and Jacobson, K. and Sherlock, M.E. and Church, P. and Wine, E. and Carroll, M.W. and Benchimol, E.I. and Lawrence, S. and Griffiths, A.M.

DOI: 10.1093/ibd/izy217

Management of paediatric ulcerative colitis, part 1: Ambulatory Care-An Evidence-based Guideline From European Crohn's and Colitis Organization and European Society of Paediatric Gastroenterology, Hepatology and Nutrition

Journal of Pediatric Gastroenterology and Nutrition

Turner, D. and Ruemmele, F.M. and Orlanski-Meyer, E. and Griffiths, A.M. and De Carpi, J.M. and Bronsky, J. and Veres, G. and Aloi, M. and Strisciuglio, C. and Braegger, C.P. and Assa, A. and Romano, C. and Hussey, S. and Stanton, M. and Pakarinen, M. and De Ridder, L. and Katsanos, K. and Croft, N. and Navas-L{\'o}pez, V. and Wilson, D.C. and Lawrence, S. and Russell, R.K.

DOI: 10.1097/MPG.0000000000002035

Management of paediatric ulcerative colitis, part 2: Acute severe colitis - An evidence-based consensus guideline from the european Crohn's and colitis organization and the european society of paediatric gastroenterology, hepatology and nutrition

Journal of Pediatric Gastroenterology and Nutrition

Turner, D. and Ruemmele, F.M. and Orlanski-Meyer, E. and Griffiths, A.M. and De Carpi, J.M. and Bronsky, J. and Veres, G. and Aloi, M. and Strisciuglio, C. and Braegger, C.P. and Assa, A. and Romano, C. and Hussey, S. and Stanton, M. and Pakarinen, M. and De Ridder, L. and Katsanos, K.H. and Croft, N. and Navas-Lopez, V.M. and Wilson, D.C. and Lawrence, S. and Russell, R.K.

DOI: 10.1097/MPG.0000000000002036

Allied Health Professional Support in Pediatric Inflammatory Bowel Disease: A Survey from the Canadian Children Inflammatory Bowel Disease Network - A Joint Partnership of CIHR and the CH.I.L.D. Foundation

Canadian Journal of Gastroenterology and Hepatology

El-Matary, W. and Benchimol, E.I. and MacK, D. and Huynh, H.Q. and Critch, J. and Otley, A. and Deslandres, C. and Jacobson, K. and Debruyn, J. and Carroll, M.W. and Wine, E. and Van Limbergen, J. and Sherlock, M. and Bax, K. and Lawrence, S. and Seidman, E. and Issenman, R. and Walters, T.D. and Church, P. and Griffiths, A.M.

DOI: 10.1155/2017/3676474

Pneumocystis jirovecii pneumonia in pediatric inflammatory bowel disease: A case report and literature review

Frontiers in Pediatrics

Lawrence, S.J. and Sadarangani, M. and Jacobson, K.

DOI: 10.3389/fped.2017.00161

The diagnostic accuracy of fecal calprotectin during the investigation of suspected pediatric inflammatory bowel disease

American Journal of Gastroenterology

Henderson, P. and Casey, A. and Lawrence, S.J. and Kennedy, N.A. and Kingstone, K. and Rogers, P. and Gillett, P.M. and Wilson, D.C.

DOI: 10.1038/ajg.2012.33

Dietary therapy in pediatric Crohn’s disease

We are exploring the impact various diets have on clinical outcomes for pediatric Crohn’s disease patients. We are also assessing the impacts that the diet therapy has on the microbiome and aryl hydrocarbon receptor activity.

COVID-19 response in pediatric IBD patients on immunosuppression

Comparison of immune response outcomes for pediatric IBD patients on various immunosuppressants.

Grants

Moffat Family Foundation

Honours & Awards

Hudson Scholar Award: 2021-2023

Poster of Distinction: International Pediatric Inflammatory Bowel Disease Conference 2022

Poster of Distinction: Canadian Association of Gastroenterology 2022

Poster of Distinction: European Society of Pediatric Gastroenterology, Hepatology and Nutrition 2017

Clinical Fellow Award, University of British Columbia: 2009

Carmichael Prize in Medicine, University of Aberdeen: 2001

Shiela McLennan Award, University of Aberdeen: 2001

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