- Overview
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There is increasing evidence to suggest diet plays an important role in inflammatory bowel disease by impacting the gut microbiome and affecting the barrier function of the gut (protective mucus layer and intestinal epithelial tight junctions). In our studies we are looking at the role of various diets and the impact they have on the clinical outcome and quality of life for our patients. We are also assessing the impact diet therapies have on the gut microbiome and immune regulation receptor pathways within the body.
We have also been assessing the immune response to vaccinations in patients with IBD on immunosuppression therapy.
- Publications
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Adalimumab vs Infliximab in Luminal Pediatric Crohn's Disease: Comparable Outcomes in a Prospective Multicenter Cohort Study
American Journal of Gastroenterology
Jennifer C. deBruyn and Hien Q. Huynh and Anne M. Griffiths and Kevan Jacobson and David Mack and Colette Deslandres and Wael El-Matary and Anthony R. Otley and Peter C. Church and Sally Lawrence and Eytan Wine and Mary Sherlock and Jeffrey Critch and Eric I. Benchimol and Prévost Jantchou and Mohsin Rashid and Matthew W. Carroll and Kevin Bax and Amanda Ricciuto and Nicholas Carman and Thomas D. Walters
DOI: 10.14309/ajg.0000000000002552
03/2024Expanding the molecular and phenotypic spectrum of CTLA-4 insufficiency
Pediatric Allergy and Immunology
DOI: 10.1111/pai.14077
2024Outcomes Following Acute Severe Colitis at Initial Presentation: A Multi-centre, Prospective, Paediatric Cohort Study
Journal of Crohn's and Colitis
DOI: 10.1093/ecco-jcc/jjad143
2024Mental Health Experiences of Adolescents and Young Adults with Inflammatory Bowel Disease During Transition to Adult Care: A Qualitative Descriptive Study
Journal of Pediatrics
DOI: 10.1016/j.jpeds.2024.114123
2024Inflammatory Bowel Disease Among Canadian Children: Comparison Between Children of Non-European Descent and Children of European Descent
Inflammatory Bowel Diseases
DOI: 10.1093/ibd/izac276
2023Transition Readiness in Youth with Inflammatory Bowel Disease
Journal of Pediatrics
Foster, A. and Chan, J.M. and Wine, E. and El-Matary, W. and Carroll, M.W. and Kroeker, K.I. and deBruyn, J.C. and Seow, C.H. and Lawrence, S. and Evans, K. and Kluthe, C. and Sharifi, N. and Pears, C. and Nicol, S. and Olayinka, L. and Fu, N. and Huynh, H.Q. and Bressler, B. and Bernstein, C.N. and Jacobson, K.
DOI: 10.1016/j.jpeds.2023.113403
2023Progression to Anti-TNF Treatment in Very Early Onset Inflammatory Bowel Disease Patients
Journal of Pediatric Gastroenterology and Nutrition
Eindor-Abarbanel, A. and Meleady, L. and Lawrence, S. and Hamilton, Z. and Krikler, G. and Lakhani, A. and Zhang, Q. and Jacobson, K.
DOI: 10.1097/MPG.0000000000003551
2022Antibody response to the BNT162b2 SARS-CoV-2 vaccine in paediatric patients with inflammatory bowel disease treated with anti-TNF therapy
Gut
Shire, Z.J. and Reicherz, F. and Lawrence, S. and Sudan, H. and Golding, L. and Majdoubi, A. and Levett, P.N. and Lavoie, P.M. and Jacobson, K.
DOI: 10.1136/gutjnl-2021-326196
2022Optimized Infliximab Induction Predicts Better Long-Term Clinical and Biomarker Outcomes Compared to Standard Induction Dosing
Journal of Pediatric Gastroenterology and Nutrition
Lawrence, S. and Faytrouni, F. and Harris, R.E. and Irvine, M. and Carrion, E. and Scott, G. and Clarke, B. and Garrick, V. and Curtis, L. and Gervais, L. and Tayler, R. and Riou, M. and Hansen, R. and Jacobson, K. and Russell, R.K.
DOI: 10.1097/MPG.0000000000003587
2022Multimodal intervention to improve the transition of patients with inflammatory bowel disease from pediatric to adult care: protocol for a randomized controlled trial
BMC Gastroenterology
Bollegala, N. and Barwick, M. and Fu, N. and Griffiths, A.M. and Keefer, L. and Kohut, S.A. and Kroeker, K.I. and Lawrence, S. and Lee, K. and Mack, D.R. and Walters, T.D. and de Guzman, J. and Tersigni, C. and Miatello, A. and Benchimol, E.I.
DOI: 10.1186/s12876-022-02307-9
2022All hands on deck: A multidisciplinary approach to SARS-CoV-2-associated MIS-C
Paediatrics and Child Health (Canada)
Lopez, A.A. and Patel, M. and Rayment, J.H. and Tam, H. and Roberts, A. and Laskin, S. and Tucker, L. and Biggs, C.M. and Ahmed, M.A. and Barakauskas, V. and Galanis, E. and Goldfarb, D. and Halparin, J. and Harris, K.C. and Kissoon, N. and Lawrence, S. and McGuffin, D. and Meckler, G. and Noel, K. and Schrader, D. and Sherwood, M. and Singh, A. and Vercauteren, S.
DOI: 10.1093/pch/pxab110
2022The Phenotypic Spectrum of New-onset IBD in Canadian Children of South Asian Ethnicity: A Prospective Multi-Centre Comparative Study
Journal of Crohn's and Colitis
Dhaliwal, J. and Carroll, M.W. and Debruyn, J.C. and Ricciuto, A. and Benchimol, E.I. and Lawrence, S. and Sherlock, M. and El-Matary, W. and Brill, H. and Church, P. and Wine, E. and Carman, N. and Muise, A. and Huynh, H. and Mack, D.R. and Walters, T.D. and Griffiths, A.M. and Jacobson, K.
DOI: 10.1093/ecco-jcc/jjab143
2022All hands on deck: A multidisciplinary approach to SARS-CoV-2-associated MIS-C,Tout le monde sur le pont: une approche multidisciplinaire du SRAS-CoV-2 associe au SIME
Paediatrics and Child Health (Canada)
Lopez, A.A. and Patel, M. and Rayment, J.H. and Tam, H. and Roberts, A. and Laskin, S. and Ahmed, M.A. and Barakauskas, V. and Galanis, E. and Goldfarb, D. and Halparin, J. and Harris, K.C. and Kissoon, N. and Lawrence, S. and Mcguffin, D. and Meckler, G. and Noel, K. and Schrader, D. and Sherwood, M. and Singh, A. and Vercauteren, S. and Tucker, L. and Biggs, C.M.
DOI: 10.1093/pch/pxac018
2022Diagnostic Delay Is Associated with Complicated Disease and Growth Impairment in Paediatric Crohn's Disease
Journal of Crohn's and Colitis
Ricciuto, A. and Mack, D.R. and Huynh, H.Q. and Jacobson, K. and Otley, A.R. and Debruyn, J. and El-Matary, W. and Deslandres, C. and Sherlock, M.E. and Critch, J.N. and Bax, K. and Jantchou, P. and Seidman, E.G. and Carman, N. and Rashid, M. and Muise, A. and Wine, E. and Carroll, M.W. and Lawrence, S. and Van Limbergen, J. and Benchimol, E.I. and Walters, T.D. and Griffiths, A.M. and Church, P.C.
DOI: 10.1093/ecco-jcc/jjaa197
2021Discontinuation of Immunosuppressive Medications in Children with Inflammatory Bowel Disease on Combination Therapy
Journal of Pediatric Gastroenterology and Nutrition
El-Matary, W. and Carroll, M.W. and Debruyn, J.C. and Huynh, H. and Wine, E. and Lawrence, S. and Chandrakumar, A. and Morel, T. and Jacobson, K.
DOI: 10.1097/MPG.0000000000002857
2020High body mass index is not associated with increased treatment failure in infliximab treated pediatric patients with inflammatory bowel disease
JGH Open
Rodin, I. and Chan, J. and Meleady, L. and Hii, C. and Lawrence, S. and Jacobson, K.
DOI: 10.1002/jgh3.12277
2020Phenotypic Variation in Paediatric Inflammatory Bowel Disease by Age: A Multicentre Prospective Inception Cohort Study of the Canadian Children IBD Network
Journal of Crohn's and Colitis
Dhaliwal, J. and Walters, T.D. and Mack, D.R. and Huynh, H.Q. and Jacobson, K. and Otley, A.R. and Debruyn, J. and El-Matary, W. and Deslandres, C. and Sherlock, M.E. and Critch, J.N. and Bax, K. and Seidman, E. and Jantchou, P. and Ricciuto, A. and Rashid, M. and Muise, A.M. and Wine, E. and Carroll, M. and Lawrence, S. and Van Limbergen, J. and Benchimol, E.I. and Church, P. and Griffiths, A.M.
DOI: 10.1093/ecco-jcc/jjz106
2020Canadian Association of Gastroenterology Clinical Practice Guideline for the Medical Management of Pediatric Luminal Crohn's Disease
Gastroenterology
DOI: 10.1053/j.gastro.2019.03.022
2019Management of Paediatric Patients with Medically Refractory Crohn's Disease Using Ustekinumab: A Multi-Centred Cohort Study
Journal of Crohn's and Colitis
Chavannes, M. and Martinez-Vinson, C. and Hart, L. and Kaniki, N. and Chao, C.-Y. and Lawrence, S. and Jacobson, K. and Hugot, J.-P. and Viala, J. and Deslandres, C. and Jantchou, P. and Seidman, E.G.
DOI: 10.1093/ecco-jcc/jjy206
2019Higher postinduction infliximab serum trough levels are associated with healing of fistulizing perianal Crohn's disease in children
Inflammatory Bowel Diseases
El-Matary, W. and Walters, T.D. and Huynh, H.Q. and Debruyn, J. and MacK, D.R. and Jacobson, K. and Sherlock, M.E. and Church, P. and Wine, E. and Carroll, M.W. and Benchimol, E.I. and Lawrence, S. and Griffiths, A.M.
DOI: 10.1093/ibd/izy217
2019Management of paediatric ulcerative colitis, part 1: Ambulatory Care-An Evidence-based Guideline From European Crohn's and Colitis Organization and European Society of Paediatric Gastroenterology, Hepatology and Nutrition
Journal of Pediatric Gastroenterology and Nutrition
Turner, D. and Ruemmele, F.M. and Orlanski-Meyer, E. and Griffiths, A.M. and De Carpi, J.M. and Bronsky, J. and Veres, G. and Aloi, M. and Strisciuglio, C. and Braegger, C.P. and Assa, A. and Romano, C. and Hussey, S. and Stanton, M. and Pakarinen, M. and De Ridder, L. and Katsanos, K. and Croft, N. and Navas-L{\'o}pez, V. and Wilson, D.C. and Lawrence, S. and Russell, R.K.
DOI: 10.1097/MPG.0000000000002035
2018Management of paediatric ulcerative colitis, part 2: Acute severe colitis - An evidence-based consensus guideline from the european Crohn's and colitis organization and the european society of paediatric gastroenterology, hepatology and nutrition
Journal of Pediatric Gastroenterology and Nutrition
Turner, D. and Ruemmele, F.M. and Orlanski-Meyer, E. and Griffiths, A.M. and De Carpi, J.M. and Bronsky, J. and Veres, G. and Aloi, M. and Strisciuglio, C. and Braegger, C.P. and Assa, A. and Romano, C. and Hussey, S. and Stanton, M. and Pakarinen, M. and De Ridder, L. and Katsanos, K.H. and Croft, N. and Navas-Lopez, V.M. and Wilson, D.C. and Lawrence, S. and Russell, R.K.
DOI: 10.1097/MPG.0000000000002036
2018Allied Health Professional Support in Pediatric Inflammatory Bowel Disease: A Survey from the Canadian Children Inflammatory Bowel Disease Network - A Joint Partnership of CIHR and the CH.I.L.D. Foundation
Canadian Journal of Gastroenterology and Hepatology
El-Matary, W. and Benchimol, E.I. and MacK, D. and Huynh, H.Q. and Critch, J. and Otley, A. and Deslandres, C. and Jacobson, K. and Debruyn, J. and Carroll, M.W. and Wine, E. and Van Limbergen, J. and Sherlock, M. and Bax, K. and Lawrence, S. and Seidman, E. and Issenman, R. and Walters, T.D. and Church, P. and Griffiths, A.M.
DOI: 10.1155/2017/3676474
2017Pneumocystis jirovecii pneumonia in pediatric inflammatory bowel disease: A case report and literature review
Frontiers in Pediatrics
Lawrence, S.J. and Sadarangani, M. and Jacobson, K.
DOI: 10.3389/fped.2017.00161
2017The diagnostic accuracy of fecal calprotectin during the investigation of suspected pediatric inflammatory bowel disease
American Journal of Gastroenterology
Henderson, P. and Casey, A. and Lawrence, S.J. and Kennedy, N.A. and Kingstone, K. and Rogers, P. and Gillett, P.M. and Wilson, D.C.
DOI: 10.1038/ajg.2012.33
2012 - Research
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Dietary therapy in pediatric Crohn’s disease
We are exploring the impact various diets have on clinical outcomes for pediatric Crohn’s disease patients. We are also assessing the impacts that the diet therapy has on the microbiome and aryl hydrocarbon receptor activity.COVID-19 response in pediatric IBD patients on immunosuppression
Comparison of immune response outcomes for pediatric IBD patients on various immunosuppressants.GrantsMoffat Family Foundation
Honours & AwardsHudson Scholar Award: 2021-2023
Poster of Distinction: International Pediatric Inflammatory Bowel Disease Conference 2022
Poster of Distinction: Canadian Association of Gastroenterology 2022
Poster of Distinction: European Society of Pediatric Gastroenterology, Hepatology and Nutrition 2017
Clinical Fellow Award, University of British Columbia: 2009
Carmichael Prize in Medicine, University of Aberdeen: 2001
Shiela McLennan Award, University of Aberdeen: 2001
Research Group MembersOlga Radivojevic, Clinical Research Coordinator
BCCHR research could help set new international standard for young children receiving bone marrow transplants
The findings from a BCCHR study played a part in integrating the multiple breath washout test into recent recommendations to screen children for pulmonary chronic graft-versus-host disease, a lung complication that can affect children who undergo a bone marrow transplant.
