Tim Oberlander

MD, FRCPC

Investigator, BC Children's Hospital
Attending Physician, Complex Pain Service, BC Children's Hospital and BC Women's Hospital & Health Centre
Developmental Pediatrician, BC Children's Hospital and BC Women's Hospital & Health Centre
R. Howard Webster Professorship in Brain Imaging and Early Child Development
Custodian, BCCH Tree of Hippocrates (a real descendent from the original tree)

Dr. Tim Oberlander is a Developmental Pediatrician, physician-scientist and the R. Howard Webster Professor in Brain Imaging and Child Development, Dept of Pediatrics and the School of Population and Public Health at UBC. As a clinician he is the medical lead for the Complex Pain Service at BC Children’s Hospital and has a particular interest in managing pain in children with developmental disabilities.

Using both cohort and population level data, Tim’s research is driven by a curiosity to answer questions about how early life experiences related to maternal mental health affects a child’s capacity to regulate stress and contributes to the early origins of social, emotional, and academic well-being and physical health across the early lifespan.

Dr. Oberlander’s work bridges developmental neurosciences and community child health and is guided by a perspective that child development is comprised of a wide variation in outcomes that extend well beyond categorical disease phenotypes.

His work provides strong evidence that exposure to both prenatal maternal mood disorders and treatment with antidepressants both influence child behavior in ways that reflect a remarkable capacity for plasticity, showing that even in the face of adversity, some children do very well. The goal of Dr. Oberlander’s work is to understand how and why this happens and identify modifiable factors that can optimize developmental health.

In early 2020, faced with the challenges of in person research during COVID-19 pandemic, Oberlander pivoted his research away from lab-based data collection to reach out to engage families and children in real world research in the world where they live their daily lives. Since 2021, he has co-led with Dr. Katelynn Boerner the Living Lab at Home (LLAH) project at BCCH, offering an innovative platform for longitudinal in-home data collection that provides researchers, clinicians, and families with the tools to collect a variety of data over long periods via a smartphone app, stress biomarkers found in saliva, and measures of daily physical activity. LLAH allows us to use real-world data to overcome barriers typically faced by child health research and provides an approach to increasing equity and accessibility for research among underrepresented populations. In this sense the LLAH offers a novel approach to answer pressing questions in child development using methods that are both feasible and acceptable and engages parents and their children across the developmental spectrum to co-design research in an everyday in-home setting.

Dr. Oberlander has an undergraduate degree in History (BA Hons) and completed his medical studies (MD) at Queen’s University, his pediatrics training at Montreal Children’s Hospital and fellowship training in Developmental Pediatrics and Pain Medicine at McGill University and Harvard University.

Academic Affiliations

  • Professor, Division of Developmental Pediatrics, Department of Pediatrics, Faculty of Medicine, University of British Columbia
  • Research Theme: Brain, Behaviour & Development
  • Research Group(s): Clinical Pharmacology; Origins of Child Health and Disease; Pain and Stress; Pathways to Healthy Birth; Visualizing the Brain

Contact Information

Location

4500 Oak St, Vancouver, BC, Canada, V6H 3N1

How the clinical encounter shapes diagnostic uncertainty in pediatric chronic pain

Journal of Pain

Neville, A. and Clemente, I. and Meldrum, M.L. and Zeltzer, L. and Jordan, A. and Oberlander, T.F. and Watson, K. and Daly-Cyr, J. and Noel, M.

DOI: 10.1016/j.jpain.2025.105406

Potential risks and benefits of prenatal selective serotonin reuptake inhibitor medications for maternal mental health and child development

Nature Mental Health

Pawluski, J. and Oberlander, T.F.

DOI: 10.1038/s44220-025-00480-w

Association of prenatal antidepressant use with internalizing behaviors from kindergarten to adolescence

Journal of Child Psychology and Psychiatry and Allied Disciplines

Nitschke, A.S. and Kaur, P. and Phagau, N. and do Valle, H.A. and Bone, J.N. and Poon, B. and Guhn, M. and Vigod, S.N. and Oberlander, T.F. and Hanley, G.E.

DOI: 10.1111/jcpp.70056

The Role of Parenting Stress as a Mediator in the Relationship Between Postpartum Depressive Symptoms and Early Childhood Internalizing Behaviour

Child Psychiatry and Human Development

Semeniuk, D. and Boerner, K.E. and Brain, U. and Ryan, D. and Oberlander, T.F.

DOI: 10.1007/s10578-023-01596-9

Association between maternal schizophrenia and risk of serious asthma exacerbations in childhood

Schizophrenia Research

Pouget, J.G. and Cohen, E. and Ray, J.G. and Wilton, A.S. and Brown, H.K. and Saunders, N.R. and Dennis, C.L. and Holloway, A.C. and Morrison, K.M. and Hanley, G.E. and Oberlander, T.F. and B{\'e}rard, A. and Tu, K. and Barker, L.C. and Vigod, S.N.

DOI: 10.1016/j.schres.2024.11.008

Prevalence Trends and Patterns of Perinatal ADHD Stimulant Medication Use in British Columbia, Canada

Pharmacoepidemiology and Drug Safety

Nitchske, A. and Salmanpour, A. and Kaur, P. and do Valle, H.A. and Elwood, C. and Gadermann, A. and Guhn, M. and Hippman, C. and Ip, A. and Karim, J.L. and Oberlander, T.F. and Socha, P.M. and Hanley, G.E.

DOI: 10.1002/pds.70129

Systematic review of autistic representation in the treatment literature for pediatric chronic pain

Journal of Pain

Boerner, K.E. and Pawliuk, C. and Heran, A. and Donaghy, B. and Moore, D. and Leong, K. and Devan, H. and Oberlander, T.F.

DOI: 10.1016/j.jpain.2025.105390

Experiences of Gender-Diverse Youth Living With Chronic Pain

Pediatrics

Boerner, K.E. and Fox, D.A. and Du, L. and Metzger, D.L. and Marshall, S. and Moore, E.M. and Narang, P. and Wharton, M.-N. and Oberlander, T.F.

DOI: 10.1542/peds.2024-067035

An examination of executive functioning in adolescents with FASD in a self-regulation intervention

Applied Neuropsychology Child

Kapasi, A. and Pei, J. and Flannigan, K. and McLachlan, K. and Oberlander, T. and Rasmussen, C.

DOI: 10.1080/21622965.2024.2349301

Canadian Network for Mood and Anxiety Treatments 2024 Clinical Practice Guideline for the Management of Perinatal Mood, Anxiety, and Related Disorders: Guide de pratique 2024 du Canadian Network for Mood and Anxiety Treatments pour le traitement des troubles de l'humeur, des troubles anxieux et des troubles connexes prinatals

Canadian Journal of Psychiatry

Vigod, S.N. and Frey, B.N. and Clark, C.T. and Grigoriadis, S. and Barker, L.C. and Brown, H.K. and Charlebois, J. and Dennis, C.-L. and Fairbrother, N. and Green, S.M. and Letourneau, N.L. and Oberlander, T.F. and Sharma, V. and Singla, D.R. and Stewart, D.E. and Tomasi, P. and Ellington, B.D. and Fleury, C. and Tarasoff, L.A. and Tomfohr-Madsen, L.M. and Da Costa, D. and Beaulieu, S. and Brietzke, E. and Kennedy, S.H. and Lam, R.W. and Milev, R.V. and Parikh, S.V. and Ravindran, A.V. and Samaan, Z. and Schaffer, A. and Taylor, V.H. and Tourjman, S.V. and Ameringen, M.V. and Yatham, L.N. and Van Lieshout, R.J.

DOI: 10.1177/07067437241303031

What Is the Impact of Second Language Exposure and Intellectual Disability Status on Executive Function and Functional Communication Outcomes in Children and Adolescents With and Without Autism Spectrum Disorder (ASD)?

Autism Research

Hutchison, S.M. and DiazPinzon, N. and Oberlander, T.F. and Iarocci, G.

DOI: 10.1002/aur.70070

Prenatal depression and child developmental vulnerability

Pediatric Research

Phagau, N.N. and Kaur, P. and Nitschke, A. and Law, M.R. and Guhn, M. and Oberlander, T.F. and Hanley, G.E.

DOI: 10.1038/s41390-025-03846-z

Examining the interaction between prenatal stress and polygenic risk for attention-deficit/hyperactivity disorder on brain growth in childhood: Findings from the DREAM BIG consortium

Developmental Psychobiology

Lpez-Vicente, M. and Szekely, E. and Lafaille-Magnan, M.-E. and Morton, J.B. and Oberlander, T.F. and Greenwood, C.M.T. and Muetzel, R.L. and Tiemeier, H. and Qiu, A. and Wazana, A. and White, T.

DOI: 10.1002/dev.22481

MyWeekInSight: Designing and Evaluating the Use of Visualization in Self-Management of Chronic Pain by Youth

arXiv

Desai, U. and Foladare, H. and Boerner, K.E. and Oberlander, T.F. and Munzner, T. and MacLean, K.E.

DOI: 10.48550/arXiv.2405.20508

A developmental framework for understanding the influence of sex and gender on health: Pediatric pain as an exemplar

Neuroscience and Biobehavioral Reviews

Boerner, K.E. and Keogh, E. and Inkster, A.M. and Nahman-Averbuch, H. and Oberlander, T.F.

DOI: 10.1016/j.neubiorev.2024.105546

Removing barriers to accessing medical cannabis for paediatric patients

Paediatrics and Child Health (Canada)

Huntsman, R.J. and Elliott, J. and Lewis, E. and Moore-Hepburn, C. and Alcorn, J. and Mansell, H. and Appendino, J.P. and Blanger, R.E. and Corley, S. and Crooks, B. and Denny, A.M. and Finkelstein, Y. and Finley, A. and Fung, R. and Gilpin, A. and Litalien, C. and Jacobs, J. and Oberlander, T.F. and Palm, A. and Palm, J. and Polewicz, M. and Quinn, D. and Rassekh, S.R. and Repetski, A. and Rieder, M.J. and Robson-McKay, A. and Seifert, B. and Shackelford, A. and Siden, H. and Szafron, M. and T Jong, G. and Vaillancourt, R. and Kelly, L.E.

DOI: 10.1093/pch/pxac129

Association of pre-existing maternal cardiovascular diseases with neurodevelopmental disorders in offspring: a cohort study in Sweden and British Columbia, Canada

International Journal of Epidemiology

Hossin, M.Z. and de la Cruz, L.F. and McKay, K.A. and Oberlander, T.F. and Sandstrm, A. and Razaz, N.

DOI: 10.1093/ije/dyad184

A systematic review of self and observer assessment of pain and related functioning in youth with brain-based developmental disabilities

Pain

Noyek, S. and Jessa, J.S. and Faulkner, V. and Boerner, K.E. and Dewan, T. and Doyle, D. and Genik, L. and Grainger-Schatz, S. and McMorris, C. and McMurtry, C.M. and Nania, C.G. and Oberlander, T. and Lorenzetti, D. and Turner, K. and Birnie, K.A.

DOI: 10.1097/j.pain.0000000000003066

A multi-centre, tolerability study of a cannabidiol-enriched Cannabis Herbal Extract for chronic headaches in adolescents: The CAN-CHA protocol

PloS one

Chhabra, M. and Lewis, E.C. and Balshaw, R. and Stewart, B. and Zaslawski, Z. and Lowthian, T. and Alidina, Z. and Chesick-Gordis, M. and Xie, W. and Dr{\"o}gem{\"o}ller, B.I. and Wright, G.E.B. and Birnie, K.A. and Boerner, K.E. and Tsang, V.W.L. and Irwin, S.L. and Pohl, D. and Weil, A.G. and Sell, E. and Penz, E. and Robson-MacKay, A. and Mbabaali, S. and Blackman, S. and Gordon, S. and Alcorn, J. and Huntsman, R.J. and Oberlander, T.F. and Finley, G.A. and Kelly, L.E.

DOI: 10.1371/journal.pone.0290185

Patient-oriented multifamily group-based care for somatization: Narratives from treated adolescents and parents.

Clinical Practice in Pediatric Psychology

Dhariwal, A.K. and Lui, A. and Gordon, S.L. and Kristen, A. and Boerner, K.E. and Opie, J. and Mohun, H. and Green, K.E. and Chapman, A.J.M. and Stanford, E.A. and Vidler, M.M. and Oberlander, T.F.

DOI: 10.1037/cpp0000500

Mental Health and Behavioral Disorders in Pregnancy

Gabbe S Obstetrics Normal and Problem Pregnancies Ninth Edition

Wisner, K.L. and Sit, D.K.Y. and Miller, E.S. and Monk, C. and Oberlander, T.F. and Huybrechts, K.F.

DOI: 10.1016/B978-0-323-93727-6.00059-1

Maternal depressed mood and serotonergic antidepressant treatment during pregnancy differentially shape the continuity between fetal"newborn neurobehaviour

Early Human Development

Campbell, K.S.J. and Brain, U. and Hanley, G.E. and Oberlander, T.F. and Lim, K.I.

DOI: 10.1016/j.earlhumdev.2024.106129

Pain and development: Interacting phenomena

Pain

Boerner, K.E. and Schechter, N.L. and Oberlander, T.F.

DOI: 10.1097/j.pain.0000000000003304

The Living Lab at Home: Feasibility and Acceptability of Multimodal In-Home Data Collection among Youth Across the Developmental Spectrum

Journal of Developmental and Behavioral Pediatrics

Boerner, K.E. and Dudarev, V. and Pearl-Dowler, L. and Wharton, M.-N. and Siden, H. and Holsti, L. and Oberlander, T.F.

DOI: 10.1097/DBP.0000000000001319

Can we more precisely classify exposure to antenatal depression and anxiety in multivariable prediction models of pregnancy and birth outcomes: a population-based cohort study

BMC Psychiatry

Thiele, G.A. and Ryan, D.M. and Oberlander, T.F. and Hanley, G.E.

DOI: 10.1186/s12888-023-05284-9

The application of epiphenotyping approaches to DNA methylation array studies of the human placenta

Epigenetics and Chromatin

Khan, A. and Inkster, A.M. and Peaherrera, M.S. and King, S. and Kildea, S. and Oberlander, T.F. and Olson, D.M. and Vaillancourt, C. and Brain, U. and Beraldo, E.O. and Beristain, A.G. and Clifton, V.L. and Del Gobbo, G.F. and Lam, W.L. and Metz, G.A.S. and Ng, J.W.Y. and Price, E.M. and Schuetz, J.M. and Yuan, V. and Portales-Casamar, ?. and Robinson, W.P.

DOI: 10.1186/s13072-023-00507-5

Response: Maternal infection, prenatal antibiotics and risk of autism in the offspring

Paediatric and Perinatal Epidemiology

Nitschke, A.S. and Oberlander, T.F. and Hanley, G.E.

DOI: 10.1111/ppe.12996

Prenatal serotonin reuptake inhibitor antidepressant exposure, SLC6A4 genetic variations, and cortisol activity in 6-year-old children of depressed mothers: A cohort study

Developmental Psychobiology

Zusman, E.Z. and Chau, C.M.Y. and Bone, J.N. and Hookenson, K. and Brain, U. and Glier, M.B. and Grunau, R.E. and Weinberg, J. and Devlin, A.M. and Oberlander, T.F.

DOI: 10.1002/dev.22425

Neurodevelopmental pediatrics: Genetic and environmental influences

Neurodevelopmental Pediatrics: Genetic and Environmental Influences

Eisenstat, D.D. and Goldowitz, D. and Oberlnder, T.F. and Yager, J.Y.

DOI: 10.1007/978-3-031-20792-1

Conditioning induced placebo-like and nocebo-like effects of thermal discomfort in adults but not in youth

British Journal of Pain

Weik, E. and Neuenschwander, R. and Edgington, B. and Jensen, K. and Tipper, C.M. and Oberlander, T.F.

DOI: 10.1177/20494637231153364

Associations between maternal depressive symptoms and selective serotonin reuptake inhibitor antidepressant treatment on internalising and anxiety behaviours in children: 12-year longitudinal study

BJPsych Open

Hutchison, S.M. and Brain, U. and Grunau, R.E. and Kuzeljevic, B. and Irvine, M. and M{\^a}sse, L.C. and Oberlander, T.F.

DOI: 10.1192/bjo.2022.623

Anxiety symptoms, psychological distress, and optimism in school staff: Testing associations with stressors and coping during the second year of the COVID-19 pandemic

Journal of Affective Disorders Reports

Hutchison, S.M. and Gonzlez, O.D.-J. and Watts, A. and Oberle, E. and Gadermann, A. and Goldfarb, D.M. and Oberlander, T.F. and Lavoie, P.M. and Msse, L.C.

DOI: 10.1016/j.jadr.2023.100662

Placebo effects in children with autism spectrum disorder

Developmental Medicine and Child Neurology

Curie, A. and Oberlander, T.F. and Jensen, K.B.

DOI: 10.1111/dmcn.15574

Feasibility and acceptability of collecting umbilical cord tissue for prenatal cannabis research: A mixed-methods research study

Women's Health

Bayrampour, H. and Langlois, J. and Likhodi, S. and Lisonkova, S. and Jevitt, C. and Oberlander, T. and Webster, G. and Mrette, S. and Vedam, S. and Janssen, P.

DOI: 10.1177/17455057231219599

Family Perspectives on In-Home Multimodal Longitudinal Data Collection for Children Who Function Across the Developmental Spectrum

Journal of Developmental and Behavioral Pediatrics

Boerner, K.E. and Pearl-Dowler, L. and Holsti, L. and Wharton, M.-N. and Siden, H. and Oberlander, T.F.

DOI: 10.1097/DBP.0000000000001183

Expert consensus on neurodevelopmental outcomes in pregnancy pharmacovigilance studies

Frontiers in Pharmacology

Bromley, R.L. and Bickle Graz, M. and Bluett-Duncan, M. and Chambers, C. and Damkier, P. and Dietrich, K. and Dolk, H. and Grant, K. and Mattson, S. and Meador, K.J. and Nordeng, H. and Oberlander, T.F. and Ornoy, A. and Revet, A. and Richardson, J. and Rovet, J. and Schuler-Faccini, L. and Smearman, E. and Simms, V. and Vorhees, C. and Wide, K. and Wood, A. and Yates, L. and Ystrom, E. and Supraja, T.A. and Adams, J.

DOI: 10.3389/fphar.2023.1094698

Exogenous oxytocin administration during labor and autism spectrum disorder

American Journal of Obstetrics and Gynecology MFM

Karim, J.L. and Solomon, S. and Abreu do Valle, H. and Zusman, E.Z. and Nitschke, A.S. and Meiri, G. and Dinstein, I. and Ip, A. and Lanphear, N. and Lanphear, B. and Hutchison, S. and Iarocci, G. and Oberlander, T.F. and Menashe, I. and Hanley, G.E.

DOI: 10.1016/j.ajogmf.2023.101010

Association between prenatal antibiotic exposure and autism spectrum disorder among term births: A population-based cohort study

Paediatric and Perinatal Epidemiology

Nitschke, A.S. and do Valle, H.A. and Vallance, B.A. and Bickford, C. and Ip, A. and Lanphear, N. and Lanphear, B. and Weikum, W. and Oberlander, T.F. and Hanley, G.E.

DOI: 10.1111/ppe.12972

When feelings hurt: Learning how to talk with families about the role of emotions in physical symptoms

Paediatrics and Child Health Canada

Boerner, K.E. and Dhariwal, A.K. and Chapman, A. and Oberlander, T.F.

DOI: 10.1093/pch/pxac052

Gestational stress and perinatal SSRIs differentially impact the maternal and neonatal microbiome-gut-brain axis

Journal of Neuroendocrinology

Pawluski, J.L. and Murail, P. and Grudet, F. and Bys, L. and Golubeva, A.V. and Bastiaanssen, T. and Oberlander, T.F. and Cryan, J.F. and O'Mahony, S.M. and Charlier, T.D.

DOI: 10.1111/jne.13261

Making Data the Drug: A Pragmatic Pilot Feasibility Randomized Crossover Trial of Data Visualization as an Intervention for Pediatric Chronic Pain

Children

Boerner, K.E. and Desai, U. and Luu, J. and MacLean, K.E. and Munzner, T. and Foladare, H. and Shen, J. and Gill, J. and Oberlander, T.F.

DOI: 10.3390/children10081355

Rethinking diagnosis-based service models for childhood neurodevelopmental disabilities in Canada: a question of equity

Paediatrics and Child Health (Canada)

Ip, A. and Poon, B.T. and Oberlander, T.F.

DOI: 10.1093/pch/pxac131

Preface

Neurodevelopmental Pediatrics: Genetic and Environmental Influences

Eisenstat, D.D. and Goldowitz, D. and Oberlnder, T.F. and Yager, J.Y.

Pain and symptom management in neurodevelopmental disorders: Sensory and nociceptive function/pain and symptom management

Neurodevelopmental Pediatrics: Genetic and Environmental Influences

Burkitt, C. and Genik, L. and Merbler, A. and Siden, H. and Oberlander, T.F. and Symons, F.

DOI: 10.1007/978-3-031-20792-1_43

Behavior regulation skills are associated with adaptive functioning in children and adolescents with prenatal alcohol exposure

Applied Neuropsychology: Child

Emily Gardiner and Sarah M. Hutchison and Kaitlyn McLachlan and Carmen Rasmussen and Jacqueline Pei and Louise C. Msse and Tim F. Oberlander and James N. Reynolds

DOI: 10.1080/21622965.2021.1936528

10 / 2022

Placebo and nocebo effects in youth: subjective thermal discomfort can be modulated by a conditioning paradigm utilizing mental states of low and high self-efficacy

British Journal of Pain

Ella Weik and Regula Neuenschwander and Karin Jensen and Tim F Oberlander and Christine Tipper

DOI: 10.1177/20494637211020042

02 / 2022

Medicinal cannabis in children and adolescents with autism spectrum disorder: A scoping review

Child: Care, Health and Development

Sarah Fletcher and Colleen Pawliuk and Angie Ip and Linda Huh and S. Rod Rassekh and Tim F. Oberlander and Harold Siden

DOI: 10.1111/cch.12909

01 / 2022

Complex chronic conditions among children born to women with schizophrenia

Schizophrenia Research

Toufeili, A. and Cohen, E. and Ray, J.G. and Wilton, A.S. and Brown, H.K. and Saunders, N.R. and Dennis, C.L. and Holloway, A.C. and Morrison, K.M. and Hanley, G.E. and Oberlander, T.F. and Brard, A. and Tu, K. and Barker, L.C. and Vigod, S.N.

DOI: 10.1016/j.schres.2021.12.018

Neighborhood environmental exposures and incidence of attention deficit/hyperactivity disorder: A population-based cohort study

Environment International

Yuchi, W. and Brauer, M. and Czekajlo, A. and Davies, H.W. and Davis, Z. and Guhn, M. and Jarvis, I. and Jerrett, M. and Nesbitt, L. and Oberlander, T.F. and Sbihi, H. and Su, J. and van den Bosch, M.

DOI: 10.1016/j.envint.2022.107120

Developmental profiles of children at risk for autism spectrum disorder at school entry

Autism Research

Ip, A. and Poon, B.T. and Hanley, G. and Guhn, M. and Oberlander, T.F.

DOI: 10.1002/aur.2742

Autism Risk and Perinatal Antibiotic Use

Pediatrics

Nitschke, A.S. and Karim, J.L. and Vallance, B.A. and Bickford, C. and Ip, A. and Lanphear, N. and Lanphear, B. and Weikum, W. and Oberlander, T.F. and Hanley, G.E.

DOI: 10.1542/peds.2022-057346

The COVID-19 pandemic impacted maternal mental health differently depending on pregnancy status and trimester of gestation

Research Square

Brard, A. and Gorgui, J. and Tchuente, V. and Lacasse, A. and Gomez, Y.-H. and Ct, S. and King, S. and Muanda, F. and Mufike, Y.M. and Boucoiran, I. and Nuyt, A.M. and Quach, C. and Ferreira, E. and Kaul, P. and Winquist, B. and O'Donnell, K. and Eltonsy, S. and Chateau, D. and Zhao, J. and Hanley, G. and Oberlander, T. and Kassai, B. and Mainbourg, S. and Bernatsky, S. and Vinet, E. and Brodeur-Doucet, A. and Demers, J. and Richeb, P. and Zaphiratos, V.

DOI: 10.21203/rs.3.rs-1167874/v1

The Canadian Mother-Child Cohort Active Surveillance Initiative (CAMCCO): Comparisons between Quebec, Manitoba, Saskatchewan, and Alberta

PLoS ONE

B{\'e}rard, A. and Kaul, P. and Eltonsy, S. and Winquist, B. and Chateau, D. and Hawken, S. and Sprague, A. and Walker, M. and Bernatsky, S. and Abrahamowicz, M. and de Moura, C.S. and Vinet, ?. and Carleton, B. and Hanley, G. and Oberlander, T. and Sheehy, O. and Gomez, Y.H. and Gorgui, J. and Savu, A.

DOI: 10.1371/journal.pone.0274355

Ensuring Equity and Inclusion in Virtual Care Best Practices for Diverse Populations of Youth with Chronic Pain

Healthcare quarterly (Toronto, Ont.)

Birnie, K.A. and Killackey, T. and Backlin, G. and Gavin, F. and Harris, C. and Jordan, I. and Kim, L. and Marianayagam, J. and Swidrovich, J. and Lalonde, C. and Tunji-Ajayi, L. and Oberlander, T. and Kirby-Allen, M. and Lambert, S. and Siden, H. and Swidrovich, J. and Noel, M. and Lalloo, C. and Stinson, J.

DOI: 10.12927/hcq.2022.26778

Data visualization as an intervention for pediatric chronic pain: a pilot feasibility study protocol for a randomized controlled crossover trial

Pilot and Feasibility Studies

Boerner, K.E. and Desai, U. and MacLean, K.E. and Munzner, T. and Foladare, H. and Gill, J. and Oberlander, T.F.

DOI: 10.1186/s40814-022-01170-5

COVID-19 Vaccine Intentions and Perceptions Among Public School Staff of the Greater Vancouver Metropolitan Area, British Columbia, Canada

Frontiers in Public Health

Watts, A.W. and Hutchison, S.M. and Bettinger, J.A. and Gadermann, A. and Oberle, E. and Oberlander, T.F. and Goldfarb, D.M. and Lavoie, P.M. and M{\^a}sse, L.C.

DOI: 10.3389/fpubh.2022.832444

Adaptive behavior, sleep, and physical activity in adolescents with fetal alcohol spectrum disorder

Research in Developmental Disabilities

Hammond, L. and Joly, V. and Kapasi, A. and Kryska, K. and Andrew, G. and Oberlander, T.F. and Pei, J. and Rasmussen, C.

DOI: 10.1016/j.ridd.2022.104366

The Impact of COVID-19 on Maternal Mental Health during Pregnancy: A Comparison between Canada and China within the CONCEPTION Cohort

International Journal of Environmental Research and Public Health

Pag{\`e}s, N. and Gorgui, J. and Wang, C. and Wang, X. and Zhao, J.-P. and Tchuente, V. and Lacasse, A. and C{\^o}t{\'e}, S. and King, S. and Muanda, F. and Mufike, Y. and Boucoiran, I. and Nuyt, A.M. and Quach, C. and Ferreira, E. and Kaul, P. and Winquist, B. and O?Donnell, K.J. and Eltonsy, S. and Chateau, D. and Hanley, G. and Oberlander, T. and Kassai, B. and Mainbourg, S. and Bernatsky, S. and Vinet, ?. and Brodeur-Doucet, A. and Demers, J. and Richeb{\'e}, P. and Zaphiratos, V. and B{\'e}rard, A.

DOI: 10.3390/ijerph191912386

The development of a patient decision aid to reduce decisional conflict about antidepressant use in pregnancy

BMC Medical Informatics and Decision Making

Hussain-Shamsy, N. and Somerton, S. and Stewart, D.E. and Grigoriadis, S. and Metcalfe, K. and Oberlander, T.F. and Schram, C. and Taylor, V.H. and Dennis, C.-L. and Vigod, S.N.

DOI: 10.1186/s12911-022-01870-1

Somatization in Adolescents With Persistent Symptoms After Concussion: A Retrospective Chart Review

The Journal of neuropsychiatry and clinical neurosciences

Green, K.E. and Purtzki, J. and Chapman, A. and Oberlander, T.F. and Silverberg, N.D. and Dhariwal, A.K.

DOI: 10.1176/appi.neuropsych.21070169

Adolescents with solid organ transplant: Using the BRIEF2 parent-report and self-report to measure parent-child agreement and everyday executive function

Applied Neuropsychology: Child

Hutchison, S.M. and Rathgeber, S.L. and De Souza, A.M. and Blydt-Hansen, T. and Msse, L.C. and Armstrong, K.R. and Oberlander, T.F.

DOI: 10.1080/21622965.2020.1800468

A text messaging intervention and quality of life in adolescents with solid organ transplants

Pediatric Transplantation

Rathgeber, S.L. and Hutchison, S.M. and De Souza, A.-M. and Lester, R. and Blydt-Hansen, T. and Human, D.G. and Guttman, O. and Oberlander, T. and Armstrong, K.R.

DOI: 10.1111/petr.14219

A cross-sectional study of the relationship between CYP2D6 and CYP2C19 variations and depression symptoms, for women taking SSRIs during pregnancy

Archives of Women's Mental Health

Hippman, C. and Slomp, C. and Morris, E. and Batallones, R. and Inglis, A. and Carrion, P. and Brain, U. and Higginson, M. and Wright, G.E.B. and Balneaves, L.G. and Ryan, D. and Nislow, C. and Ross, C.J.D. and Gaedigk, A. and Oberlander, T.F. and Austin, J.

DOI: 10.1007/s00737-021-01149-w

Profiling placental DNA methylation associated with maternal SSRI treatment during pregnancy

Scientific Reports

Inkster, A.M. and Konwar, C. and Pe{\~n}aherrera, M.S. and Brain, U. and Khan, A. and Price, E.M. and Schuetz, J.M. and Portales-Casamar, ?. and Burt, A. and Marsit, C.J. and Vaillancourt, C. and Oberlander, T.F. and Robinson, W.P.

DOI: 10.1038/s41598-022-26071-8

A multicentre Canadian survey of caregiver perspectives on COVID vaccine-related pain and stress for their family

British Journal of Pain

Ali, S. and Kammerer, E. and Thompson, G. and Mater, A. and Rajagopal, M. and Bone, J.N. and Birnie, K.A. and Oberlander, T. and Chambers, C.T. and Goldman, R.D.

DOI: 10.1177/20494637221090452

School staff and teachers during the second year of COVID-19: Higher anxiety symptoms, higher psychological distress, and poorer mental health compared to the general population

Journal of Affective Disorders Reports

Hutchison, S.M. and Watts, A. and Gadermann, A. and Oberle, E. and Oberlander, T.F. and Lavoie, P.M. and Msse, L.C.

DOI: 10.1016/j.jadr.2022.100335

Canadian surveillance study of complex regional pain syndrome in children

Pain

Baerg, K. and Tupper, S.M. and Chu, L.M. and Cooke, N. and Dick, B.D. and Dor{\'e}-Bergeron, M.-J. and Findlay, S. and Ingelmo, P.M. and Lamontagne, C. and Mesaroli, G. and Oberlander, T.F. and Poolacherla, R. and Spencer, A.O. and Stinson, J. and Finley, G.A.

DOI: 10.1097/j.pain.0000000000002482

Associations between Prenatal Exposure to Serotonergic Medications and Biobehavioral Stress Regulation: Protocol for a Systematic Review and Meta-analysis

JMIR Research Protocols

Zusman, E.Z. and Lavu, A. and Pawliuk, C. and Pawluski, J. and Hutchison, S.M. and Platt, R.W. and Oberlander, T.F.

DOI: 10.2196/33363

Preconception mental health and the relationship between antenatal depression or anxiety and gestational diabetes mellitus: a population-based cohort study

BMC pregnancy and childbirth

Thiele, G.A. and Ryan, D.M. and Oberlander, T.F. and Hanley, G.E.

DOI: 10.1186/s12884-022-05002-5

Maternal Schizophrenia and the Risk of a Childhood Chronic Condition

Schizophrenia bulletin

Vigod, S.N. and Ray, J.G. and Cohen, E. and Wilton, A.S. and Saunders, N.R. and Barker, L.C. and Berard, A. and Dennis, C.-L. and Holloway, A.C. and Morrison, K. and Oberlander, T.F. and Hanley, G. and Tu, K. and Brown, H.K.

DOI: 10.1093/schbul/sbac091

The PPD-ACT app in Canada: feasibility and a latent class analysis of participants with postpartum depression recruited to a psychiatric genetics study using a mobile application

BMC Psychiatry

Collaton, J. and Dennis, C.-L. and Taylor, V.H. and Grigoriadis, S. and Oberlander, T.F. and Frey, B.N. and Van Lieshout, R. and Guintivano, J. and Meltzer-Brody, S. and Kennedy, J.L. and Vigod, S.N.

DOI: 10.1186/s12888-022-04363-7

The influence of early-life residential exposure to different vegetation types and paved surfaces on early childhood development: A population-based birth cohort study

Environment International

Jarvis, I. and Sbihi, H. and Davis, Z. and Brauer, M. and Czekajlo, A. and Davies, H.W. and Gergel, S.E. and Guhn, M. and Jerrett, M. and Koehoorn, M. and Nesbitt, L. and Oberlander, T.F. and Su, J. and van den Bosch, M.

DOI: 10.1016/j.envint.2022.107196

The association between prenatal greenspace exposure and Autism spectrum disorder, and the potentially mediating role of air pollution reduction: A population-based birth cohort study

Environment International

Pagalan, L. and Oberlander, T.F. and Hanley, G.E. and Rosella, L.C. and Bickford, C. and Weikum, W. and Lanphear, N. and Lanphear, B. and Brauer, M. and van den Bosch, M.

DOI: 10.1016/j.envint.2022.107445

Associations Between Prenatal Exposure to Serotonergic Medications and Biobehavioral Stress Regulation: Protocol for a Systematic Review and Meta-analysis (Preprint)

Enav Z Zusman and Alekhya Lavu and Colleen Pawliuk and Jodi Pawluski and Sarah M Hutchison and Robert W Platt and Tim F Oberlander

DOI: 10.2196/preprints.33363

09 / 2021

Improving the regulation of medical cannabis in Canada to better serve pediatric patients,Amliorer la rglementation du cannabis mdical au Canada pour mieux servir les patients pdiatriques

CMAJ

Huntsman, R.J. and Kelly, L.E. and Alcorn, J. and Appendino, J.P. and Blanger, R.E. and Crooks, B. and Finkelstein, Y. and Gilpin, A. and Lewis, E. and Litalien, C. and Jacobs, J. and Moore-Hepburn, C. and Oberlander, T. and Rassekh, S.R. and Repetski, A.E. and Rieder, M.J. and Shackelford, A. and Siden, H. and Szafron, M. and T Jong, G.W. and Vaillancourt, R.

DOI: 10.1503/cmaj.202169-f

The association between natural environments and childhood mental health and development: A systematic review and assessment of different exposure measurements

International Journal of Hygiene and Environmental Health

Davis, Z. and Guhn, M. and Jarvis, I. and Jerrett, M. and Nesbitt, L. and Oberlander, T. and Sbihi, H. and Su, J. and van den Bosch, M.

DOI: 10.1016/j.ijheh.2021.113767

Prenatal stress and child development: The future that lies ahead

Prenatal Stress and Child Development

Wazana, A. and Szkely, E. and Oberlander, T.F.

DOI: 10.1007/978-3-030-60159-1_21

Prenatal antidepressant exposure and child development at kindergarten age: a population-based study

Pediatric Research

Park, M. and Hanley, G.E. and Guhn, M. and Oberlander, T.F.

DOI: 10.1038/s41390-020-01269-6

Perinatal selective serotonin reuptake inhibitor (SSRI) and other antidepressant exposure effects on anxiety and depressive behaviors in offspring: A review of findings in humans and rodent models

Reproductive Toxicology

Hutchison, S.M. and Msse, L.C. and Pawluski, J.L. and Oberlander, T.F.

DOI: 10.1016/j.reprotox.2020.11.013

Improving the regulation of medical cannabis in Canada to better serve pediatric patients

CMAJ

Huntsman, R.J. and Kelly, L.E. and Alcorn, J. and Appendino, J.P. and Blanger, R.E. and Crooks, B. and Finkelstein, Y. and Gilpin, A. and Lewis, E. and Litalien, C. and Jacobs, J. and Moore-Hepburn, C. and Oberlander, T. and Rassekh, S.R. and Repetski, A.E. and Rieder, M.J. and Shackelford, A. and Siden, H. and Szafron, M. and T'Jong, G.W. and Vaillancourt, R.

DOI: 10.1503/cmaj.202169

The other side of prenatal depression: Developmental outcomes associated with antidepressant medication therapy

Prenatal Stress and Child Development

Rotem-Kohavi, N. and Goodman, S.H. and Wazana, A. and Oberlander, T.F.

DOI: 10.1007/978-3-030-60159-1_19

Prenatal stress and child development-pathways, mechanisms and interventions

Prenatal Stress and Child Development

Oberlander, T.F. and Szkely, E. and Wazana, A.

DOI: 10.1007/978-3-030-60159-1_1

Impact of the COVID-19 Pandemic on Maternal Mental Health during Pregnancy: The CONCEPTION Study " Phase I

SSRN

Brard, A. and Lacasse, A. and Gomez, Y.-H. and Gorgui, J. and Ct, S.M. and King, S. and Tchuente, V. and Muanda, F.T. and Lumu, Y.M. and Boucoiran, I. and Nuyt, A.-M. and Quach, C.T. and Ferreira, E. and Kaul, P. and Winquist, B. and O?Donnell, K.J. and Eltonsy, S. and Chateau, D. and Zhao, J.-P. and Hanley, G.E. and Oberlander, T.F. and Kassai, B. and Mainbourg, S. and Bernatsky, S. and Vinet, ?. and Brodeur-Doucet, A. and Demers, J. and Richeb, P. and Zaphiratos, V. and Wang, C. and Wang, X.

DOI: 10.2139/ssrn.3777974

Assessing the association between lifetime exposure to greenspace and early childhood development and the mediation effects of air pollution and noise in Canada: a population-based birth cohort study

The Lancet. Planetary health

Jarvis, I. and Davis, Z. and Sbihi, H. and Brauer, M. and Czekajlo, A. and Davies, H.W. and Gergel, S.E. and Guhn, M. and Jerrett, M. and Koehoorn, M. and Oberlander, T.F. and Su, J. and van den Bosch, M.

DOI: 10.1016/S2542-5196(21)00235-7

Antidepressant exposure in pregnancy and child sensorimotor and visuospatial development: Antidepressants and child development

Journal of Psychiatric Research

Galbally, M. and Watson, S.J. and Spigset, O. and Boyce, P. and Oberlander, T.F. and Lewis, A.J.

DOI: 10.1016/j.jpsychires.2020.11.035

The Association between Cumulative Lifetime Exposure to Greenspace and Early Childhood Development " Is the Relation Mediated by Reduction in Air Pollution and Noise?

SSRN

Jarvis, I. and Davis, Z. and Sbihi, H. and Brauer, M. and Czekajlo, A. and Davies, H.W. and Gergel, S.E. and Guhn, M. and Jerrett, M. and Koehoorn, M. and Oberlander, T.F. and Su, J. and van den Bosch, M.

DOI: 10.2139/ssrn.3831160

Preliminary insights into the genetic architecture of postpartum depressive symptom severity using polygenic risk scores

Personalized Medicine in Psychiatry

Pouget, J.G. and Taylor, V.H. and Dennis, C.-L. and Grigoriadis, S. and Oberlander, T. and Frey, B.N. and Van Lieshout, R. and Guintivano, J. and Meltzer-Brody, S. and Kennedy, J.L. and Vigod, S.N.

DOI: 10.1016/j.pmip.2021.100081

Association of Epidural Analgesia during Labor and Delivery with Autism Spectrum Disorder in Offspring

JAMA - Journal of the American Medical Association

Hanley, G.E. and Bickford, C. and Ip, A. and Lanphear, N. and Lanphear, B. and Weikum, W. and Zwaigenbaum, L. and Oberlander, T.F.

DOI: 10.1001/jama.2021.14986

The microbiome-gut-brain axis: A new window to view the impact of prenatal stress on early neurodevelopment

Prenatal Stress and Child Development

Rotem-Kohavi, N. and Keane, J. and Clarke, G. and Dinan, T.G. and Cryan, J.F. and McCarthy, F.P. and Oberlander, T.F. and O'Mahony, S.M.

DOI: 10.1007/978-3-030-60159-1_8

Prenatal Stress and Child Development

Prenatal Stress and Child Development

Szkely, E. and Oberlander, T. and Wazana, A.

DOI: 10.1007/978-3-030-60159-1

Prenatal antidepressant exposure and sex differences in neonatal corpus callosum microstructure

Developmental Psychobiology

Campbell, K.S.J. and Williams, L.J. and Bjornson, B.H. and Weik, E. and Brain, U. and Grunau, R.E. and Miller, S.P. and Oberlander, T.F.

DOI: 10.1002/dev.22125

Maternal Serotonin Reuptake Inhibitor Antidepressants Have Acute Effects on Fetal Heart Rate Variability in Late Gestation

Frontiers in Psychiatry

Campbell, K.S.J. and Collier, A.C. and Irvine, M.A. and Brain, U. and Rurak, D.W. and Oberlander, T.F. and Lim, K.I.

DOI: 10.3389/fpsyt.2021.680177

Correspondence: Adolescents during COVID-19: Youth with disabilities more likely to report challenges with anxiety and mental health

Journal of Affective Disorders Reports

Hutchison, S.M. and Holley, P. and Manuel, A. and Msse, L.C. and Oberlander, T.F. and Jedwab, J.

DOI: 10.1016/j.jadr.2020.100072

Prenatal exposure to maternal depression is related to the functional connectivity organization underlying emotion perception in 8-10-month-old infants " Preliminary findings

Infant Behavior and Development

Rotem-Kohavi, N. and Virji-Babul, N. and Oberlander, T.F.

DOI: 10.1016/j.infbeh.2021.101545

Epidural Analgesia and Autism Spectrum Disorder Risk - The Challenges Inherent in Complex Observational Research

JAMA Pediatrics

Hanley, G.E. and Ip, A. and Oberlander, T.F.

DOI: 10.1001/jamapediatrics.2021.0382

Symptoms, adverse events, and outcomes in the use of medicinal cannabis in children and adolescents with autism spectrum disorder: a scoping review protocol.

JBI evidence synthesis

Fletcher S and Pawliuk C and Ip A and Oberlander T and Siden H

DOI: 10.11124/jbies-20-00001 PubMed: 33165173

11 / 2020

Effects of maternal depression and prenatal SSRI exposure on executive functions and susceptibility to household chaos in 6-year-old children: prospective cohort study

BJPsych Open

Gurpreet Dhaliwal and Whitney M. Weikum and Alexia Jolicoeur-Martineau and Ursula Brain and Ruth E. Grunau and Tim F. Oberlander

DOI: 10.1192/bjo.2020.73

09 / 2020

The PPD-ACT App: Feasibility of a mobile application for recruiting women with postpartum depression and psychosis to a psychiatric genetics study (Preprint)

Joanna Collaton and Cindy-Lee Dennis and Valerie H Taylor and Sophie Grigoriadis and Tim F Oberlander and Benicio N Frey and Ryan Van Lieshout and Jerry Guintivano and Samantha Meltzer-Brody and James L Kennedy and Simone N Vigod

DOI: 10.2196/preprints.24327

09 / 2020

Plasma Choline Concentration Is Positively Correlated with Visual Acuity in 18-Month Old Toddlers: Preliminary Findings.

Current developments in nutrition

Montgomery S and Rossen L and Zibrik D and Dyer R and Oberlander T and Lamers Y

05 / 2020

Nutritional Status in Breastfed 18-Month Old Toddlers: Cross-Sectional Findings.

Current developments in nutrition

Montgomery S and Ho G and Rossen L and Zibrik D and Dyer R and Oberlander T and Lamers Y

05 / 2020

Blood DHA, Choline, and Lutein Concentrations and Their Correlation with Cognitive and Behavioral Outcomes in 18-Month Old Toddlers: Preliminary Findings.

Current developments in nutrition

Rossen L and Montgomery S and Zibrik D and Dyer R and Oberlander T and Lamers Y

05 / 2020

Advanced neuroimaging: A window into the neural correlates of fetal programming related to prenatal exposure to maternal depression and SSRIs

Seminars in Perinatology

Rotem-Kohavi, N. and Williams, L.J. and Oberlander, T.F.

DOI: 10.1016/j.semperi.2020.151223

Correction : In Utero Exposure to Citalopram Mitigates Maternal Stress Effects on Fetal Brain Development (ACS Chem. Neurosci. (2019) 10:7 (3307-3317) DOI: 10.1021/acschemneuro.9b00180)

ACS Chemical Neuroscience

Velasquez, J.C. and Zhao, Q. and Chan, Y. and Galindo, L.C.M. and Simasotchi, C. and Wu, D. and Hou, Z. and Herod, S.M. and Oberlander, T.F. and Gil, S. and Fournier, T. and Burd, I. and Andrews, A.M. and Bonnin, A.

DOI: 10.1021/acschemneuro.9b00683

Conditioned Placebo- and Nocebo-Like Effects in Adolescents: The Role of Conscious Awareness, Sensory Discrimination, and Executive Function

Frontiers in Psychiatry

Neuenschwander, R. and Weik, E. and Tipper, C.M. and Jensen, K. and Oberlander, T.F.

DOI: 10.3389/fpsyt.2020.586455

Differences in White Matter Microstructure among Children with Developmental Coordination Disorder

JAMA Network Open

Zwicker, J.G. and Brown-Lum, M. and Izadi-Najafabadi, S. and Oberlander, T.F. and Rauscher, A. and Zwicker, J.G.

DOI: 10.1001/jamanetworkopen.2020.1184

The Association between Antidepressant Exposure and Birth Defects-Are We There Yet?

JAMA Psychiatry

Wisner, K.L. and Oberlander, T.F. and Huybrechts, K.F.

DOI: 10.1001/jamapsychiatry.2020.1512

Socieconomic status and psychotropic medicine use during pregnancy: a population-based study in British Columbia, Canada

Archives of Women's Mental Health

Hanley, G.E. and Park, M. and Oberlander, T.F.

DOI: 10.1007/s00737-020-01034-y

Identification of Pediatric Autism Spectrum Disorder Cases Using Health Administrative Data

Autism Research

Bickford, C.D. and Oberlander, T.F. and Lanphear, N.E. and Weikum, W.M. and Janssen, P.A. and Ouellette-Kuntz, H. and Hanley, G.E.

DOI: 10.1002/aur.2252

Decision-making about antidepressant medication use in pregnancy: A comparison between women making the decision in the preconception period versus in pregnancy

BMC Psychiatry

Barker, L.C. and Dennis, C.-L. and Hussain-Shamsy, N. and Stewart, D.E. and Grigoriadis, S. and Metcalfe, K. and Oberlander, T.F. and Schram, C. and Taylor, V.H. and Vigod, S.N.

DOI: 10.1186/s12888-020-2478-8

Placebo by Proxy and Nocebo by Proxy in Children: A Review of Parents' Role in Treatment Outcomes

Frontiers in Psychiatry

Czerniak, E. and Oberlander, T.F. and Weimer, K. and Kossowsky, J. and Enck, P.

DOI: 10.3389/fpsyt.2020.00169

The role of glucocorticoid and mineralocorticoid receptor DNA methylation in antenatal depression and infant stress regulation

Psychoneuroendocrinology

Galbally, M. and Watson, S.J. and van IJzendoorn, M. and Saffery, R. and Ryan, J. and de Kloet, E.R. and Oberlander, T.F. and Lappas, M. and Lewis, A.J.

DOI: 10.1016/j.psyneuen.2020.104611

126 The Canadian Neonatal Brain Platform: A three-pillar approach.

Paediatrics & Child Health

Luck D and Ding Y and Luu TM and Oberlander T and Grunau R and Miller S and Lodygensky G

05 / 2019

Alterations in Resting-State Networks Following In Utero Selective Serotonin Reuptake Inhibitor Exposure in the Neonatal Brain

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

Rotem-Kohavi, N. and Williams, L.J. and Virji-Babul, N. and Bjornson, B.H. and Brain, U. and Werker, J.F. and Grunau, R.E. and Miller, S.P. and Oberlander, T.F.

DOI: 10.1016/j.bpsc.2018.08.004

Transcranial direct current stimulation (tDCS) for depression in pregnancy: A pilot randomized controlled trial

Brain Stimulation

Vigod, S.N. and Murphy, K.E. and Dennis, C.-L. and Oberlander, T.F. and Ray, J.G. and Daskalakis, Z.J. and Blumberger, D.M.

DOI: 10.1016/j.brs.2019.06.019

Calmer: A robot for managing acute pain effectively in preterm infants in the neonatal intensive care unit

Pain Reports

Holsti, L. and MacLean, K. and Oberlander, T. and Synnes, A. and Brant, R.

DOI: 10.1097/PR9.0000000000000727

Selective serotonin reuptake inhibitor effects on neural biomarkers of perinatal depression

Archives of Women's Mental Health

Pawluski, J.L. and Brain, U. and Hammond, G.L. and Oberlander, T.F.

DOI: 10.1007/s00737-018-0931-1

Evaluating pain in cerebral palsy: comparing assessment tools using the International Classification of Functioning, Disability and Health

Disability and Rehabilitation

Schiariti, V. and Oberlander, T.F.

DOI: 10.1080/09638288.2018.1472818

Myelin Water Fraction Imaging of the Brain in Children with Prenatal Alcohol Exposure

Alcoholism: Clinical and Experimental Research

McLachlan, K. and Vavasour, I. and MacKay, A. and Brain, U. and Oberlander, T. and Loock, C. and Reynolds, J.N. and Beaulieu, C.

DOI: 10.1111/acer.14024

Hub distribution of the brain functional networks of newborns prenatally exposed to maternal depression and SSRI antidepressants

Depression and Anxiety

Rotem-Kohavi, N. and Williams, L.J. and Muller, A.M. and Abdi, H. and Virji-Babul, N. and Bjornson, B.H. and Brain, U. and Werker, J.F. and Grunau, R.E. and Miller, S.P. and Oberlander, T.F.

DOI: 10.1002/da.22906

A patient decision aid for antidepressant use in pregnancy: Pilot randomized controlled trial

Journal of Affective Disorders

Vigod, S.N. and Hussain-Shamsy, N. and Stewart, D.E. and Grigoriadis, S. and Metcalfe, K. and Oberlander, T.F. and Schram, C. and Taylor, V.H. and Dennis, C.-L.

DOI: 10.1016/j.jad.2019.01.051

In utero exposure to citalopram mitigates maternal stress effects on fetal brain development

ACS Chemical Neuroscience

Velasquez, J.C. and Zhao, Q. and Chan, Y. and Galindo, L.C.M. and Simasotchi, C. and Wu, D. and Hou, Z. and Herod, S.M. and Oberlander, T.F. and Gil, S. and Fournier, T. and Burd, I. and Andrews, A.M. and Bonnin, A.

DOI: 10.1021/acschemneuro.9b00180

Impact of prenatal selective serotonin reuptake inhibitor antidepressant exposure and maternal mood on physical activity, dietary intake, and markers of adiposity at age 6 years

Journal of Developmental and Behavioral Pediatrics

Hutchison, S.M. and Msse, L.C. and Glier, M.B. and Brain, U. and Devlin, A.M. and Oberlander, T.F.

DOI: 10.1097/DBP.0000000000000658

A 6-year longitudinal study: Are maternal depressive symptoms and Selective Serotonin Reuptake Inhibitor (SSRI) antidepressant treatment during pregnancy associated with everyday measures of executive function in young children?

Early Human Development

Hutchison, S.M. and Msse, L.C. and Brain, U. and Oberlander, T.F.

DOI: 10.1016/j.earlhumdev.2018.10.009

Risk factors for hospitalizations associated with depression among women during the years around a birth: A retrospective cohort study

International Journal of Population Data Science

Fairthorne, J.C. and Hanley, G.E. and Brant, R. and Oberlander, T.F.

DOI: 10.23889/ijpds.v4i1.453

Prevalence and characteristics of adults with fetal alcohol spectrum disorder in corrections: A Canadian case ascertainment study

BMC Public Health

McLachlan, K. and McNeil, A. and Pei, J. and Brain, U. and Andrew, G. and Oberlander, T.F.

DOI: 10.1186/s12889-018-6292-x

Prenatal SSRI antidepressant use and maternal internalizing symptoms during pregnancy and postpartum: Exploring effects on infant temperament trajectories for boys and girls

Journal of Affective Disorders

Erickson, N.L. and Hancock, G.R. and Oberlander, T.F. and Brain, U. and Grunau, R.E. and Gartstein, M.A.

DOI: 10.1016/j.jad.2019.08.003

Association of Prenatal Exposure to Air Pollution with Autism Spectrum Disorder

JAMA Pediatrics

Pagalan, L. and Bickford, C. and Weikum, W. and Lanphear, B. and Brauer, M. and Lanphear, N. and Hanley, G.E. and Oberlander, T.F. and Winters, M.

DOI: 10.1001/jamapediatrics.2018.3101

Children's stress regulation mediates the association between prenatal maternal mood and child executive functions for boys, but not girls

Development and Psychopathology

Neuenschwander, R. and Hookenson, K. and Brain, U. and Grunau, R.E. and Devlin, A.M. and Weinberg, J. and Diamond, A. and Oberlander, T.F.

DOI: 10.1017/S095457941800041X

Socioeconomic status and treatment of depression during pregnancy: A retrospective population-based cohort study in British Columbia, Canada

Archives of Women's Mental Health

Hanley, G.E. and Park, M. and Oberlander, T.F.

DOI: 10.1007/s00737-018-0866-6

In-utero Selective Serotonin Reuptake Inhibitor Antidepressant Exposure: Fetal Programing and Developmental Interactions With Context

Clinical Pharmacology and Therapeutics

Park, M. and Oberlander, T.F.

DOI: 10.1002/cpt.1134

Perinatal selective serotonin reuptake inhibitor medication (SSRI) effects on social behaviors, neurodevelopment and the epigenome

Neuroscience and Biobehavioral Reviews

Gemmel, M. and Bgi, E. and Ragan, C. and Hazlett, M. and Dubovicky, M. and van den Hove, D.L. and Oberlander, T.F. and Charlier, T.D. and Pawluski, J.L.

DOI: 10.1016/j.neubiorev.2017.04.023

Maternal depression trajectories from pregnancy to 3years postpartum are associated with childrens behavior and executive functions at 3 and 6years

Archives of Women's Mental Health

Park, M. and Brain, U. and Grunau, R.E. and Diamond, A. and Oberlander, T.F.

DOI: 10.1007/s00737-017-0803-0

Perinatal selective serotonin reuptake inhibitor (SSRI) effects on body weight at birth and beyond: A review of animal and human studies

Reproductive Toxicology

Hutchison, S.M. and Msse, L.C. and Pawluski, J.L. and Oberlander, T.F.

DOI: 10.1016/j.reprotox.2018.02.004

Born to be Wise: A population registry data linkage protocol to assess the impact of modifiable early-life environmental exposures on the health and development of children

BMJ Open

Van Den Bosch, M. and Brauer, M. and Burnett, R. and Davies, H.W. and Davis, Z. and Guhn, M. and Jarvis, I. and Nesbitt, L. and Oberlander, T. and Rugel, E. and Sbihi, H. and Su, J.G. and Jerrett, M.

DOI: 10.1136/bmjopen-2018-026954

Variations from morning to afternoon of middle cerebral and umbilical artery blood flow, and fetal heart rate variability, and fetal characteristics in the normally developing fetus

Journal of Clinical Ultrasound

Avitan, T. and Sanders, A. and Brain, U. and Rurak, D. and Oberlander, T.F. and Lim, K.

DOI: 10.1002/jcu.22569

Depressed Women of Low Socioeconomic Status Have High Numbers of Physician Visits in the Year Before Pregnancy: Implications for Care

Journal of Clinical Medicine Research

Jenny Fairthorne and Gillian E. Hanley and Tim F. Oberlander

DOI: 10.14740/jocmr3377w

HOUSEHOLD CHAOS, MATERNAL DEPRESSION AND PRENATAL SSRI EXPOSURE INTERACT TO AFFECT EXECUTIVE FUNCTION OF 6 YEAR OLD CHILDREN.

Paediatrics & Child Health

Dhaliwal G and Weikum W and Jolicoeur-Martineau A and Brain U and Grunau R and Oberlander T

DOI: 10.1093/pch/pxx086.019

05 / 2017

The Risk of Teenage Motherhood Decreases in A Dose Response Fashion With Increasing SES: A Population-Based Study From British Columbia, Canada

JWHG

Jenny Fairthorne

DOI: 10.17303/jwhg.2017.4.104

03 / 2017

Post-Partum Depression and Infant Crying Behavior

Encyclopedia on Early Childhood Development

Oberlander TF, Rotem-Kohavi N*. Post-Partum Depression and Infant Crying Behavior. In Encyclopedia on Early Childhood Development. Centre of Excellence for Early Childhood Development Website. 2017 (Rev. ed.) http://www.child-encyclopedia.com/pages/PDF/OberlanderANGxp.pdf

Unpacking the Heterogeneity of Cognitive Functioning in Children and Adolescents with Fetal Alcohol Spectrum Disorder: Determining the Role of Moderators and Strengths

Advances in Neurodevelopmental Disorders

McLachlan, K. and Paolozza, A. and Kully-Martens, K. and Portales-Casamar, E. and Pavlidis, P. and Andrew, G. and Hanlon-Dearman, A. and Loock, C. and McFarlane, A. and Nikkel, S.M. and Pei, J. and Oberlander, T.F. and Samdup, D. and Reynolds, J.N. and Rasmussen, C.

DOI: 10.1007/s41252-017-0034-4

Predictors of Recovery from Depression and Anxiety in Women: A Longitudinal Study from Childbirth to 6 Years

Canadian Journal of Psychiatry

Shankar, R. and Badker, R. and Brain, U. and Oberlander, T.F. and Misri, S.

DOI: 10.1177/0706743716677725

Infants and adults have similar regional functional brain organization for the perception of emotions

Neuroscience Letters

Rotem-Kohavi, N. and Oberlander, T.F. and Virji-Babul, N.

DOI: 10.1016/j.neulet.2017.04.031

Developmental changes in serotonin signaling: Implications for early brain function, behavior and adaptation

Neuroscience

Brummelte, S. and Mc Glanaghy, E. and Bonnin, A. and Oberlander, T.F.

DOI: 10.1016/j.neuroscience.2016.02.037

Variations in Neurodevelopmental Outcomes in Children with Prenatal SSRI Antidepressant Exposure

Birth Defects Research

Rotem-Kohavi, N. and Oberlander, T.F.

DOI: 10.1002/bdr2.1076

Response to use of domperidone and risk of ventricular arrhythmia in the postpartum period: Getting to the heart of the matter

Pharmacoepidemiology and Drug Safety

Smolina, K. and Morgan, S. and Mintzes, B. and Hanley, G. and Oberlander, T.

DOI: 10.1002/pds.4229

Developmental origins of self-regulation: Prenatal maternal stress and psychobiological development during childhood

Parental Stress and Early Child Development: Adaptive and Maladaptive Outcomes

Neuenschwander, R. and Oberlander, T.F.

DOI: 10.1007/978-3-319-55376-4_6

Disentangling maternal depression and antidepressant use during pregnancy as risks for autism in children

JAMA - Journal of the American Medical Association

Oberlander, T.F. and Zwaigenbaum, L.

DOI: 10.1001/jama.2017.3414

Afternoon cortisol provides a link between self-regulated anger and peer-reported aggression in typically developing children in the school context

Developmental Psychobiology

Oberle, E. and McLachlan, K. and Catherine, N.L.A. and Brain, U. and Schonert-Reichl, K.A. and Weinberg, J. and Oberlander, T.F.

DOI: 10.1002/dev.21522

Childrens stress regulation mediates the association between depressed and/or anxious prenatal maternal mood and child executive functions for boys, but not girls

Development and Psychopathology

Antenatal exposure to antidepressants is associated with altered brain development in very preterm-born neonates

Neuroscience

Podrebarac, S.K. and Duerden, E.G. and Chau, V. and Grunau, R.E. and Synnes, A. and Oberlander, T.F. and Miller, S.P.

DOI: 10.1016/j.neuroscience.2016.11.025

Postpartum domperidone use in British Columbia: a retrospective cohort study

CMAJ Open

K. Smolina and S. G. Morgan and G. E. Hanley and T. F. Oberlander and B. Mintzes

DOI: 10.9778/cmajo.20150067

01 / 2016

Postpartum Hemorrhage and Use of Serotonin Reuptake Inhibitor Antidepressants in Pregnancy

Obstetrics and Gynecology

Hanley, G.E. and Smolina, K. and Mintzes, B. and Oberlander, T.F. and Morgan, S.G.

DOI: 10.1097/AOG.0000000000001200

Developmental Effects of Prenatal Selective Serotonin Reuptake Inhibitor Exposure in Perspective: Are We Comparing Apples to Apples?

Journal of the American Academy of Child and Adolescent Psychiatry

Oberlander, T.F. and Vigod, S.N.

DOI: 10.1016/j.jaac.2016.02.012

Fetal effects of in utero serotonin reuptake inhibitor (SRI) antidepressant exposure

Fetal Development: Research on Brain and Behavior, Environmental Influences, and Emerging Technologies

Hanley, G. and Hookenson, K. and Rurak, D. and Oberlander, T.F.

DOI: 10.1007/978-3-319-22023-9_18

SLC6A4 promoter region methylation and socio-emotional stress response in very preterm and full-term infants

Epigenomics

Montirosso, R. and Provenzi, L. and Giorda, R. and Fumagalli, M. and Morandi, F. and Sirgiovanni, I. and Pozzoli, U. and Grunau, R. and Oberlander, T.F. and Mosca, F. and Borgatti, R.

DOI: 10.2217/epi-2016-0010

Sculpting infant soothability: the role of prenatal SSRI antidepressant exposure and neonatal SLC6A4 methylation status

Developmental Psychobiology

Gartstein, M.A. and Hookenson, K.V. and Brain, U. and Devlin, A.M. and Grunau, R.E. and Oberlander, T.F.

DOI: 10.1002/dev.21414

Genetic variation in catechol-O-methyltransferase modifies effects of clonidine treatment in chronic fatigue syndrome

Pharmacogenomics Journal

Hall, K.T. and Kossowsky, J. and Oberlander, T.F. and Kaptchuk, T.J. and Saul, J.P. and Wyller, V.B. and Fagermoen, E. and Sulheim, D. and Gjerstad, J. and Winger, A. and Mukamal, K.J.

DOI: 10.1038/tpj.2016.53

Dysregulation of the cortisol diurnal rhythm following prenatal alcohol exposure and early life adversity

Alcohol

McLachlan, K. and Rasmussen, C. and Oberlander, T.F. and Loock, C. and Pei, J. and Andrew, G. and Reynolds, J. and Weinberg, J.

DOI: 10.1016/j.alcohol.2016.03.003

The association between domperidone and ventricular arrhythmia in the postpartum period

Pharmacoepidemiology and Drug Safety

Smolina, K. and Mintzes, B. and Hanley, G.E. and Oberlander, T.F. and Morgan, S.G.

DOI: 10.1002/pds.4035

Pain

Health Care for People with Intellectual and Developmental Disabilities Across the Lifespan

Barney, C.C. and Belew, J.L. and Valkenburg, A.J. and Symons, F.J. and Oberlander, T.F.

DOI: 10.1007/978-3-319-18096-0_143

A patient decision aid for antidepressant use in pregnancy: Study protocol for a randomized controlled trial

Trials

Vigod, S. and Hussain-Shamsy, N. and Grigoriadis, S. and Howard, L.M. and Metcalfe, K. and Oberlander, T.F. and Schram, C. and Stewart, D.E. and Taylor, V.H. and Dennis, C.-L.

DOI: 10.1186/s13063-016-1233-4

Enhancing cognitive and social"emotional development through a simple-to-administer mindfulness-based school program for elementary school children: A randomized controlled trial.

Developmental Psychology

Kimberly A. Schonert-Reichl and Eva Oberle and Molly Stewart Lawlor and David Abbott and Kimberly Thomson and Tim F. Oberlander and Adele Diamond

DOI: 10.1037/a0038454

01 / 2015

Prenatal exposure to serotonin reuptake inhibitor antidepressants and childhood behavior

Pediatric Research

Hanley, G.E. and Brain, U. and Oberlander, T.F.

DOI: 10.1038/pr.2015.77

Trends and determinants of prescription drug use during pregnancy and postpartum in British Columbia, 2002-2011: A population-based cohort study

PLoS ONE

Smolina, K. and Hanley, G.E. and Mintzes, B. and Oberlander, T.F. and Morgan, S.

DOI: 10.1371/journal.pone.0128312

Prenatal antidepressant exposure associated with CYP2E1 DNA methylation change in neonates

Epigenetics

Gurnot, C. and Martin-Subero, I. and Mah, S.M. and Weikum, W. and Goodman, S.J. and Brain, U. and Werker, J.F. and Kobor, M.S. and Esteller, M. and Oberlander, T.F. and Hensch, T.K.

DOI: 10.1080/15592294.2015.1026031

A randomized controlled trial of eye shields and earmuffs to reduce pain response of preterm infants

Journal of Neonatal Nursing

Aita, M. and Goulet, C. and Oberlander, T.F. and Snider, L. and Johnston, C.

DOI: 10.1016/j.jnn.2014.11.004

Do We Know If They Work and If They Are Safe: Second-Generation Antipsychotics for Treatment of Autism Spectrum Disorders and Disruptive Behavior Disorders in Children and Adolescents

The Science and Ethics of Antipsychotic Use in Children

Elbe, D. and Mc Glanaghy, E. and Oberlander, T.F.

DOI: 10.1016/B978-0-12-800016-8.00003-9

Evaluation of the Neurobehavioral Screening Tool in Children with Fetal Alcohol Spectrum Disorder (FASD)

Journal of Population Therapeutics and Clinical Pharmacology

LaFrance MA, McLachlan K*, Nash K, Andrew G, Loock C, Oberlander TF, Korean G, Rasmussen C. Evaluation of the Neurobehavioral Screening Tool in Children with Fetal Alcohol Spectrum Disorder (FASD). Journal of Population Therapeutics and Clinical Pharmacology. 2014;21(2):e197-e210

PubMed: 24897061

05 / 2014

Rising antipsychotic prescriptions for children and youth: cross-sectoral solutions for a multimodal problem

Canadian Medical Association Journal

N. Di Pietro and J. Illes and for the Canadian Working Group on Antipsychotic Medications and Children

DOI: 10.1503/cmaj.131604

03 / 2014

The impact of maternal positive and negative affect on fetal physiology and diurnal patterns.

The Israel journal of psychiatry and related sciences

Hanley GE and Rurak D and Lim K and Brain U and Oberlander TF

PubMed: 25372560

01 / 2014

Transcranial direct current stimulation (tDCS) for treatment of major depression during pregnancy: Study protocol for a pilot randomized controlled trial

Trials

Vigod, S. and Dennis, C.-L. and Daskalakis, Z. and Murphy, K. and Ray, J. and Oberlander, T. and Somerton, S. and Hussain-Shamsy, N. and Blumberger, D.

DOI: 10.1186/1745-6215-15-366

The effect of perinatal exposures on the infant: Antidepressants and depression

Best Practice and Research: Clinical Obstetrics and Gynaecology

Hanley, G.E. and Oberlander, T.F.

DOI: 10.1016/j.bpobgyn.2013.09.001

The symphonic structure of childhood stress reactivity: Patterns of sympathetic, parasympathetic, and adrenocortical responses to psychological challenge

Development and Psychopathology

Quas, J.A. and Yim, I.S. and Oberlander, T.F. and Nordstokke, D. and Essex, M.J. and Armstrong, J.M. and Bush, N. and Obradovi?, J. and Boyce, W.T.

DOI: 10.1017/S0954579414000480

The impact of maternal positive and negative affect on fetal physiology and diurnal patterns

Israel Journal of Psychiatry and Related Sciences

Hanley, G.E. and Rurak, D. and Lim, K. and Brain, U. and Oberlander, T.F.

Neonatal pain and COMT Val158Met genotype in relation to serotonin transporter (SLC6A4) promoter methylation in very preterm children at school age

Frontiers in Behavioral Neuroscience

Cecil M. Y. Chau and Manon Ranger and Dian Sulistyoningrum and Angela M. Devlin and Tim F. Oberlander and Ruth E. Grunau

DOI: 10.3389/fnbeh.2014.00409

Evaluation of the neurobehavioral screening tool in children with fetal alcohol spectrum disorders (FASD)

Journal of Population Therapeutics and Clinical Pharmacology

LaFrance, M.-A. and McLachlan, K. and Nash, K. and Andrew, G. and Loock, C. and Oberlander, T.F. and Koren, G. and Rasmussen, C.

Pain in children with autism

Mental Health and Pain: Somatic and Psychiatric Components of Pain in Mental Health

Oberlander, T.F. and Zeltzer, L.K.

DOI: 10.1007/978-2-8178-0414-9_12

Maternal and Fetal Factors That Influence Prenatal Exposure to Selective Serotonin Reuptake Inhibitor Antidepressants

Psychopharmacology and Pregnancy

Alison K. Shea and Tuan-Anh Thi Nguyen and Ursula Brain and Dan Rurak and Tim F. Oberlander

DOI: 10.1007/978-3-642-54562-7_4

Biomarkers of pain: physiological indices of pain reactivity in infants and children

Oxford Medicine Online

Susanne Brummelte and Tim F. Oberlander and Kenneth D. Craig

DOI: 10.1093/med/9780199642656.003.0038

11 / 2013

Infant developmental outcomes following prenatal exposure to antidepressants, and maternal depressed mood and positive affect

Early Human Development

Hanley, G.E. and Brain, U. and Oberlander, T.F.

DOI: 10.1016/j.earlhumdev.2012.12.012

Physician variability in treating pain and irritability of unknown origin in children with severe neurological Impairment

Pain Research and Management

Siden, H.B. and Carleton, B.C. and Oberlander, T.F.

DOI: 10.1155/2013/193937

Factors impacting decisions to decline or adhere to antidepressant medication in perinatal women with mood and anxiety disorders

Depression and Anxiety

Misri, S. and Eng, A.B. and Abizadeh, J. and Blackwell, E. and Spidel, A. and Oberlander, T.F.

DOI: 10.1002/da.22137

Antidepressant use during pregnancy and serotonin transporter genotype (SLC6A4) Affect newborn serum reelin levels

Developmental Psychobiology

Brummelte, S. and Galea, L.A.M. and Devlin, A.M. and Oberlander, T.F.

DOI: 10.1002/dev.21056

Intervention Minimizing Preterm Infants' Exposure to NICU Light and Noise

Clinical Nursing Research

Aita, M. and Johnston, C. and Goulet, C. and Oberlander, T.F. and Snider, L.

DOI: 10.1177/1054773812469223

The impact of prenatal serotonin reuptake inhibitor (SRI) antidepressant exposure and maternal mood on mother-infant interactions at 3 months of age

Infant Behavior and Development

Weikum, W.M. and Mayes, L.C. and Grunau, R.E. and Brain, U. and Oberlander, T.F.

DOI: 10.1016/j.infbeh.2013.04.001

Prenatal serotonin reuptake inhibitor (SRI) antidepressant exposure and serotonin transporter promoter genotype (SLC6A4) influence executive functions at 6 years of age

Frontiers in Cellular Neuroscience

Weikum, W.M. and Brain, U. and Chau, C.M.Y. and Grunau, R.E. and Boyce, W.T. and Diamond, A. and Oberlander, T.F.

DOI: 10.3389/fncel.2013.00180

Pain in Children with Disabilities

Encyclopedia of Pain

Kenneth D. Craig and Tim F. Oberlander

DOI: 10.1007/978-3-540-29805-2_3090

A tale of 2s: Optimizing maternal-child health in the context of antenatal maternal depression and antidepressant use

Canadian Journal of Psychiatry

Oberlander, T.F. and Wisner, K.L.

DOI: 10.1177/070674371205700901

Fetal serotonin reuptake inhibitor antidepressant exposure: Maternal and fetal factors

Canadian Journal of Psychiatry

Shea, A.K. and Oberlander, T.F. and Rurak, D.

DOI: 10.1177/070674371205700902

Fetal serotonin signaling: Setting pathways for early childhood development and behavior

Journal of Adolescent Health

Oberlander, T.F.

DOI: 10.1016/j.jadohealth.2012.04.009

Biopsychosocial determinants of treatment outcome for mood and anxiety disorders up to 8 months postpartum

Archives of Women's Mental Health

Misri, S. and Albert, G. and Abizadeh, J. and Kendrick, K. and Carter, D. and Ryan, D. and Oberlander, T.F.

DOI: 10.1007/s00737-012-0288-9

Prenatal SSRI exposure alters neonatal corticosteroid binding globulin, infant cortisol levels, and emerging HPA function

Psychoneuroendocrinology

Pawluski, J.L. and Brain, U.M. and Underhill, C.M. and Hammond, G.L. and Oberlander, T.F.

DOI: 10.1016/j.psyneuen.2011.11.011

Frontal EEG/ERP correlates of attentional processes, cortisol and motivational states in adolescents from lower and higher socioeconomic status

Frontiers in Human Neuroscience

Amedeo D'Angiulli and Joanne Weinberg and Tim F. Oberlander and Ruth E. Grunau and Clyde Hertzman and Stefania Maggi

DOI: 10.3389/fnhum.2012.00306

Third trimester fetal pulmonary artery Doppler blood flow velocity characteristics following prenatal selective serotonin reuptake inhibitor (SSRI) exposure

Early Human Development

Lim, K. and Sanders, A. and Brain, U. and Riggs, W. and Oberlander, T.F. and Rurak, D.

DOI: 10.1016/j.earlhumdev.2012.01.004

Neurodevelopmental outcomes following prenatal exposure to serotonin reuptake inhibitor antidepressants: A "social teratogen" or moderator of developmental risk?

Birth Defects Research Part A - Clinical and Molecular Teratology

Hanley, G.E. and Oberlander, T.F.

DOI: 10.1002/bdra.23032

Prenatal exposure to antidepressants and depressed maternal mood alter trajectory of infant speech perception

Proceedings of the National Academy of Sciences of the United States of America

Weikum, W.M. and Oberlander, T.F. and Hensch, T.K. and Werker, J.F.

DOI: 10.1073/pnas.1121263109

Focused attention, heart rate deceleration, and cognitive development in preterm and full-term infants

Developmental Psychobiology

Petrie Thomas, J.H. and Whitfield, M.F. and Oberlander, T.F. and Synnes, A.R. and Grunau, R.E.

DOI: 10.1002/dev.20597

Afternoon Cortisol in Elementary School Classrooms: Associations with Peer and Teacher Support and Child Behavior

School Mental Health

Catherine, N.L.A. and Schonert-Reichl, K.A. and Hertzman, C. and Oberlander, T.F.

DOI: 10.1007/s12310-012-9076-y

Reply to Klinger et al

Birth Defects Research Part A - Clinical and Molecular Teratology

Hanley, G.E. and Oberlander, T.F.

DOI: 10.1002/bdra.23095

Pediatric analgesic clinical trial designs, measures, and extrapolation: Report of an FDA Scientific Workshop

Pediatrics

Berde, C.B. and Walco, G.A. and Krane, E.J. and Anand, K.J.S. and Aranda, J.V. and Craig, K.D. and Dampier, C.D. and Finkel, J.C. and Grabois, M. and Johnston, C. and Lantos, J. and Lebel, A. and Maxwell, L.G. and McGrath, P. and Oberlander, T.F. and Schanberg, L.E. and Stevens, B. and Taddio, A. and Von Baeyer, C.L. and Yaster, M. and Zempsky, W.T.

DOI: 10.1542/peds.2010-3591

Reply

Acta Psychiatrica Scandinavica

Warburton, W. and Hertzman, C. and Oberlander, T.F.

DOI: 10.1111/j.1600-0447.2010.01643.x

Antidepressant use in children and adolescents: Practice touch points to guide paediatricians

Paediatrics and Child Health

Oberlander, T.F. and Miller, A.R.

DOI: 10.1093/pch/16.9.549

Third trimester fetal heart rate and doppler middle cerebral artery blood flow velocity characteristics during prenatal selective serotonin reuptake inhibitor exposure

Pediatric Research

Rurak, D. and Lim, K. and Sanders, A. and Brain, U. and Riggs, W. and Oberlander, T.F.

DOI: 10.1203/PDR.0b013e31821ba11a

Does breastfeeding reduce acute procedural pain in preterm infants in the neonatal intensive care unit? A randomized clinical trial

Pain

Holsti, L. and Oberlander, T.F. and Brant, R.

DOI: 10.1016/j.pain.2011.07.022

Pain in Individuals with Intellectual Disabilities

Clinical Pain Management: A Practical Guide

Oberlander, T.F. and Burkitt, C.C. and Symons, F.J.

DOI: 10.1002/9781444329711.ch39

Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birth

PLoS ONE

Devlin, A.M. and Brain, U. and Austin, J. and Oberlander, T.F.

DOI: 10.1371/journal.pone.0012201

Prenatal alcohol exposure alters biobehavioral reactivity to pain in newborns

Alcoholism: Clinical and Experimental Research

Oberlander, T.F. and Jacobson, S.W. and Weinberg, J. and Grunau, R.E. and Molteno, C.D. and Jacobson, J.L.

DOI: 10.1111/j.1530-0277.2009.01137.x

Physiological correlates of memory recall in infancy: Vagal tone, cortisol, and imitation in preterm and full-term infants at 6 months

Infant Behavior and Development

Haley, D.W. and Grunau, R.E. and Weinberg, J. and Keidar, A. and Oberlander, T.F.

DOI: 10.1016/j.infbeh.2009.10.007

Antenatal depression and anxiety affect postpartum parenting stress: A longitudinal, prospective study

Canadian Journal of Psychiatry

Misri, S. and Kendrick, K. and Oberlander, T.F. and Norris, S. and Tomfohr, L. and Zhang, H. and Grunau, R.E.

DOI: 10.1177/070674371005500405

A register study of the impact of stopping third trimester selective serotonin reuptake inhibitor exposure on neonatal health

Acta Psychiatrica Scandinavica

Warburton, W. and Hertzman, C. and Oberlander, T.F.

DOI: 10.1111/j.1600-0447.2009.01490.x

Prenatal effects of selective serotonin reuptake inhibitor antidepressants, serotonin transporter promoter genotype (SLC6A4), and maternal mood on child behavior at 3 years of age

Archives of Pediatrics and Adolescent Medicine

Oberlander, T.F. and Papsdorf, M. and Brain, U.M. and Misri, S. and Ross, C. and Grunau, R.E.

DOI: 10.1001/archpediatrics.2010.51

Cortisol, behavior, and heart rate reactivity to immunization pain at 4 months corrected age in infants born very preterm

Clinical Journal of Pain

Grunau, R.E. and Tu, M.T. and Whitfield, M.F. and Oberlander, T.F. and Weinberg, J. and Yu, W. and Thiessen, P. and Gosse, G. and Scheifele, D.

DOI: 10.1097/AJP.0b013e3181e5bb00

The management of depression during pregnancy: a report from the American Psychiatric Association and the American College of Obstetricians and Gynecologists

General Hospital Psychiatry

Kimberly A. Yonkers and Katherine L. Wisner and Donna E. Stewart and Tim F. Oberlander and Diana L. Dell and Nada Stotland and Susan Ramin and Linda Chaudron and Charles Lockwood

DOI: 10.1016/j.genhosppsych.2009.04.003

09 / 2009

Pain in individuals with intellectual and developmental disabilities

Journal of Pain Management

Symons, F.J. and Oberlander, T.F. and Kehl, L.J.

Neonatal S100B protein levels after prenatal exposure to selective serotonin reuptake inhibitors

Pediatrics

Pawluski, J.L. and Galea, L.A.M. and Brain, U. and Papsdorf, M. and Oberlander, T.F.

DOI: 10.1542/peds.2009-0442

Depression during pregnancy: The potential impact of increased risk for fetal aneuploidy on maternal mood

Clinical Genetics

Hippman, C. and Oberlander, T.F. and Honer, W.G. and Misri, S. and Austin, J.C.

DOI: 10.1111/j.1399-0004.2008.01056.x

The management of depression during pregnancy: a report from the American Psychiatric Association and the American College of Obstetricians and Gynecologists.

Obstetrics and gynecology

Yonkers, K.A. and Wisner, K.L. and Stewart, D.E. and Oberlander, T.F. and Dell, D.L. and Stotland, N. and Ramin, S. and Chaudron, L. and Lockwood, C.

DOI: 10.1097/AOG.0b013e3181ba0632

Sustained neurobehavioral effects of exposure to ssri antidepressants during development: Molecular to clinical evidence

Clinical Pharmacology and Therapeutics

Oberlander, T.F. and Gingrich, J.A. and Ansorge, M.S.

DOI: 10.1038/clpt.2009.201

Caregiving behavior and interactions of prenatally depressed mothers (antidepressant-treated and non-antidepressant-treated) during newborn acute pain

Infant Mental Health Journal

Warnock, F.F. and Bakeman, R. and Shearer, K. and Misri, S. and Oberlander, T.

DOI: 10.1002/imhj.20220

Editorial: Optimizing neurodevelopmental outcomes in infants and children following prenatal SSRI exposure

Pediatric Health

Oberlander, T.F.

DOI: 10.2217/phe.09.56

Is it painful or not? Discriminant validity of the Behavioral Indicators of Infant Pain (BIIP) scale

Clinical Journal of Pain

Holsti, L. and Grunau, R.E. and Oberlander, T.F. and Osiovich, H.

DOI: 10.1097/AJP.0b013e318158c5e5

Effects of timing and duration of gestational exposure to serotonin reuptake inhibitor antidepressants: Population-based study

British Journal of Psychiatry

Oberlander, T.F. and Warburton, W. and Misri, S. and Aghajanian, J. and Hertzman, C.

DOI: 10.1192/bjp.bp.107.037101

Hypothalamic-pituitary-adrenal (HPA) axis function in 3-month old infants with prenatal selective serotonin reuptake inhibitor (SSRI) antidepressant exposure

Early Human Development

Oberlander, T.F. and Grunau, R. and Mayes, L. and Riggs, W. and Rurak, D. and Papsdorf, M. and Misri, S. and Weinberg, J.

DOI: 10.1016/j.earlhumdev.2008.06.008

Contingency learning and reactivity in preterm and full-term infants at 3 months

Infancy

Haley, D.W. and Grunau, R.E. and Oberlander, T.F. and Weinberg, J.

DOI: 10.1080/15250000802458682

Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses

Epigenetics

Oberlander, T.F. and Weinberg, J. and Papsdorf, M. and Grunau, R. and Misri, S. and Devlin, A.M.

DOI: 10.4161/epi.3.2.6034

Major congenital malformations following prenatal exposure to serotonin reuptake inhibitors and benzodiazepines using population-based health data

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Oberlander, T.F. and Warburton, W. and Misri, S. and Riggs, W. and Aghajanian, J. and Hertzman, C.

DOI: 10.1002/bdrb.20144

Infant serotonin transporter (SLC6A4) promoter genotype is associated with adverse neonatal outcomes after prenatal exposure to serotonin reuptake inhibitor medications

Molecular Psychiatry

Oberlander, T.F. and Bonaguro, R.J. and Misri, S. and Papsdorf, M. and Ross, C.J.D. and Simpson, E.M.

DOI: 10.1038/sj.mp.4002007

Pain management for children with a developmental disability in a primary care setting

Pain in Children: A Practical Guide for Primary Care

Siden, H. and Oberlander, T.F.

DOI: 10.1007/978-1-59745-476-6_4

Biobehavioural reactivity to pain in preterm infants: a marker of neuromotor development

Developmental Medicine & Child Neurology

Ruth E Grunau and Michael F Whitfield and Taryn Fay and Liisa Holsti and Timothy Oberlander and Marilynn L Rogers

DOI: 10.1111/j.1469-8749.2006.tb01298.x

02 / 2007

In reply [5]

Archives of General Psychiatry

Oberlander, T.F. and Warburton, W. and Misri, S. and Aghajanian, J. and Hertzman, C.

DOI: 10.1001/archpsyc.64.7.867

Toward comprehensive treatment for postpartum depressed mothers and their infants

British Columbia Medical Journal

Lansky, P.S. and Oberlander, T.

Externalizing and attentional behaviors in children of depressed mothers treated with a selective serotonin reuptake inhibitor antidepressant during pregnancy

Archives of Pediatrics and Adolescent Medicine

Oberlander, T.F. and Reebye, P. and Misri, S. and Papsdorf, M. and Kim, J. and Grunau, R.E.

DOI: 10.1001/archpedi.161.1.22

Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: Characterization of gene duplication events

Clinical Pharmacology and Therapeutics

Gaedigk, A. and Ndjountch, L. and Divakaran, K. and Dianne Bradford, L. and Zineh, I. and Oberlander, T.F. and Brousseau, D.C. and McCarver, D.G. and Johnson, J.A. and Alander, S.W. and Riggs, K.W. and Leeder, J.S.

DOI: 10.1038/sj.clpt.6100033

Neonatal outcomes after prenatal exposure to selective serotonin reuptake inhibitor antidepressants and maternal depression using population-based linked health data

Archives of General Psychiatry

Oberlander, T.F. and Warburton, W. and Misri, S. and Aghajanian, J. and Hertzman, C.

DOI: 10.1001/archpsyc.63.8.898

Behavioral responses to pain are heightened after clustered care in preterm infants born between 30 and 32 weeks gestational age

Clinical Journal of Pain

Holsti, L. and Grunau, R.E. and Whifield, M.F. and Oberlander, T.F. and Lindh, V.

DOI: 10.1097/01.ajp.0000210921.10912.47

Internalizing behaviors in 4-year-old children exposed in utero to psychotropic medications

American Journal of Psychiatry

Misri, S. and Reebye, P. and Kendrick, K. and Carter, D. and Ryan, D. and Grunau, R.E. and Oberlander, T.F.

DOI: 10.1176/ajp.2006.163.6.1026

Stereoselective disposition of fluoxetine and norfluoxetine during pregnancy and breast-feeding

British Journal of Clinical Pharmacology

Kim, J. and Riggs, K.W. and Misri, S. and Kent, N. and Oberlander, T.F. and Grunau, R.E. and Fitzgerald, C. and Rurak, D.W.

DOI: 10.1111/j.1365-2125.2005.02538.x

A prospective controlled study of neurodevelopment in HIV-uninfected children exposed to combination antiretroviral drugs in pregnancy

Pediatrics

Alimenti, A. and Forbes, J.C. and Oberlander, T.F. and Money, D.M. and Grunau, R.E. and Papsdorf, M.P. and Maan, E. and Cole, L.J. and Burdge, D.R.

DOI: 10.1542/peds.2006-0525

Summary proceedings from the neonatal pain-control group

Pediatrics

Anand, K.J.S. and Aranda, J.V. and Berde, C.B. and Buckman, S. and Capparelli, E.V. and Carlo, W. and Hummel, P. and Johnston, C.C. and Lantos, J. and Tutag-Lehr, V. and Lynn, A.M. and Maxwell, L.G. and Oberlander, T.F. and Raju, T.N.K. and Soriano, S.G. and Taddio, A. and Walco, G.A.

DOI: 10.1542/peds.2005-0620C

Analgesia and local anesthesia during invasive procedures in the neonate

Clinical Therapeutics

Anand, K.J.S. and Johnston, C.C. and Oberlander, T.F. and Taddio, A. and Lehr, V.T. and Walco, G.A.

DOI: 10.1016/j.clinthera.2005.06.018

Body movements: An important additional factor in discriminating pain from stress in preterm infants

Clinical Journal of Pain

Holsti, L. and Grunau, R.E. and Oberlander, T.F. and Whitfield, M.F. and Weinberg, J.

DOI: 10.1097/01.ajp.0000146163.30776.44

Neonatal procedural pain exposure predicts lower cortisol and behavioral reactivity in preterm infants in the NICU

Pain

Grunau, R.E. and Holsti, L. and Haley, D.W. and Oberlander, T. and Weinberg, J. and Solimano, A. and Whitfield, M.F. and Fitzgerald, C. and Yu, W.

DOI: 10.1016/j.pain.2004.10.020

Pain reactivity in 2-month-old infants after prenatal and postnatal selective serotonin reuptake inhibitor medication exposure

Pediatrics

Oberlander, T.F. and Grunau, R.E. and Fitzgerald, C. and Papsdorf, M. and Rurak, D. and Riggs, W.

DOI: 10.1542/peds.2004-0420

Analgesia and anesthesia for neonates: Study design and ethical issues

Clinical Therapeutics

Anand, K.J.S. and Aranda, J.V. and Berde, C.B. and Buckman, S. and Capparelli, E.V. and Carlo, W.A. and Hummel, P. and Lantos, J. and Johnsto, C.C. and Lehr, V.T. and Lynn, A.M. and Maxwell, L.G. and Oberlander, T.F. and Raju, T.N.K. and Soriano, S.G. and Taddio, A. and Walco, G.A.

DOI: 10.1016/j.clinthera.2005.06.021

Prior pain induces heightened motor responses during clustered care in preterm infants in the NICU

Early Human Development

Holsti, L. and Grunau, R.E. and Oberlander, T.F. and Whitfield, M.F.

DOI: 10.1016/j.earlhumdev.2004.08.002

Relation between prenatal maternal mood and anxiety and neonatal health

Canadian Journal of Psychiatry

Misri, S. and Oberlander, T.F. and Fairbrother, N. and Carter, D. and Ryan, D. and Kuan, A.J. and Reebye, P.

DOI: 10.1177/070674370404901006

Does Prone or Supine Position Influence Pain Responses in Preterm Infants at 32 Weeks Gestational Age?

Clinical Journal of Pain

Grunau, R.E. and Linhares, M.B.M. and Holsti, L. and Oberlander, T.F. and Whitfield, M.F.

DOI: 10.1097/00002508-200403000-00003

Specific newborn individualized developmental care and assessment program movements are associated with acute pain in preterm infants in the neonatal intensive care unit

Pediatrics

Holsti, L. and Grunau, R.E. and Oberlander, T.F. and Whitfield, M.F.

DOI: 10.1542/peds.114.1.65

Expression of Pain in Children with Autism

Clinical Journal of Pain

Nader, R. and Oberlander, T.F. and Chambers, C.T. and Craig, K.D.

DOI: 10.1097/00002508-200403000-00005

Pharmacologic factors associated with transient neonatal symptoms following prenatal psychotropic medication exposure

Journal of Clinical Psychiatry

Oberlander, T.F. and Misri, S. and Fitzgerald, C.E. and Kostaras, X. and Rurak, D. and Riggs, W.

DOI: 10.4088/JCP.v65n0214

Are there developmentally distinct motor indicators of pain in preterm infants?

Early Human Development

Morison, S.J. and Holsti, L. and Grunau, R.E. and Whitfield, M.F. and Oberlander, T.F. and Chan, H.W.P. and Williams, L.

DOI: 10.1016/S0378-3782(03)00044-6

Does parenchymal brain injury affect biobehavioral pain responses in very low birth weight infants at 32 weeks' postconceptional age?

Pediatrics

Oberlander, T.F. and Grunau, R.E. and Fitzgerald, C. and Whitfield, M.F.

DOI: 10.1542/peds.110.3.570

Prevention in adulthood: Forging a doctor-patient partnership

Primary Care - Clinics in Office Practice

Oberlander, T. and Saul, J.Philip

DOI: 10.1016/S0095-4543(02)00018-0

Prolonged prenatal psychotropic medication exposure alters neonatal acute pain response

Pediatric Research

Oberlander, T.F. and Grunau, R.E. and Fitzgerald, C. and Ellwood, A.-L. and Misri, S. and Rurak, D. and Riggs, K.W.

DOI: 10.1203/00006450-200204000-00008

Methodological considerations for the use of heart rate variability as a measure of pain reactivity in vulnerable infants

Clinics in Perinatology

Oberlander, T. and Saul, J.Philip

DOI: 10.1016/S0095-5108(02)00013-1

Relations between behavioral and cardiac autonomic reactivity to acute pain in preterm neonates

Clinical Journal of Pain

Morison, S.J. and Grunau, R.E. and Oberlander, T.F. and Whitfield, M.F.

DOI: 10.1097/00002508-200112000-00010

Pain reactivity in former extremely low birth weight infants at corrected age 8 months compared with term born controls

Infant Behavior and Development

Eckstein Grunau, R. and Oberlander, T.F. and Whitfield, M.F. and Fitzgerald, C. and Morison, S.J. and Philip Saul, J.

DOI: 10.1016/S0163-6383(01)00065-0

Demographic and therapeutic determinants of pain reactivity in very low birth weight neonates at 32 weeks' postconceptional age

Pediatrics

Grunau, R.E. and Oberlander, T.F. and Whitfield, M.F. and Fitzgerald, C. and Lee, S.K.

DOI: 10.1542/peds.107.1.105

Pain Assessment and Management in Infants and Young Children with Developmental Disabilities

Infants and Young Children

Oberlander, T.F.

DOI: 10.1097/00001163-200114020-00006

Beliefs about pain among professionals working with children with significant neurologic impairment

Developmental Medicine and Child Neurology

Oberlander, T.F. and O'Donnell, M.E.

DOI: 10.1017/S0012162201230254

Biobehavioral Pain Responses in Former Extremely Low Birth Weight Infants at Four Months' Corrected Age

Pediatrics

Tim F. Oberlander and Ruth Eckstein Grunau and Michael F. Whitfield and Colleen Fitzgerald and Sandy Pitfield and J. Philip Saul

DOI: 10.1542/peds.105.1.e6

01 / 2000

Prenatal and Breast Milk Morphine Exposure Following Maternal Intrathecal Morphine Treatment

Journal of Human Lactation

Oberlander, T.F. and Robeson, P. and Ward, V. and Huckin, R.S. and Kamani, A. and Harpur, A. and McDonald, W.

DOI: 10.1177/089033440001600210

Evaluating treatment outcome in an interdisciplinary pediatric pain service

Pain Research and Management

Bennett, S.M. and Chambers, C.T. and Bellows, D. and Court, C.A. and Huntsman, E. and Montgomery, C. and Oberlander, T.F. and Sheriff, M. and Siden, H.

DOI: 10.1155/2000/767058

The Developmental Character of Cardiac Autonomic Responses to an Acute Noxious Event in 4- and 8-Month-Old Healthy Infants

Pediatric Research

Tim F Oberlander and Ruth Eckstein Grunau and Sandy Pitfield and Michael F Whitfield and J Philip Saul

DOI: 10.1203/00006450-199904010-00011

04 / 1999

Biobehavioral responses to acute pain in adolescents with a significant neurologic impairment

Clinical Journal of Pain

Oberlander, T.F. and Gilbert, C.A. and Chambers, C.T. and O'Donnell, M.E. and Craig, K.D.

DOI: 10.1097/00002508-199909000-00007

Pain in children with significant neurological impairment

Journal of Developmental and Behavioral Pediatrics

Oberlander, T.F. and O'Donnell, M.E. and Montgomery, C.J.

DOI: 10.1097/00004703-199908000-00006

The developmental character of cardiac autonomic responses to an acute noxious event in 4-and 8-month-old healthy infants

Pediatric Research

Oberlander, T.F. and Grunau, R.E. and Pitfield, S. and Whitfield, M.F. and Saul, J.P.

Pain management of junctional epidermolysis bullosa in an 11-year-old boy

Pediatric Dermatology

Chiu, Y.-K. and Prendiville, J.S. and Bennett, S.M. and Montgomery, C.J. and Oberlander, T.F.

DOI: 10.1046/j.1525-1470.1999.00120.x

Bedside application of the neonatal facial coding system in pain assessment of premature neonates

Pain

Grunau, R.E. and Oberlander, T. and Holsti, L. and Whitfield, M.F.

DOI: 10.1016/S0304-3959(98)00046-3

Cardiac Autonomic and Behavioral Responses to Acute Pain in 4 Month Old Infants 80

Pediatric Research

Tim F. Oberlander and Ruth V.E. Grunau and Micheal F. Whitfield and J. Philip Saul

DOI: 10.1203/00006450-199704001-00101

04 / 1997

Developmental character and long-term consequences of pain in infants and children

Child and Adolescent Psychiatric Clinics of North America

Anand, K.S. and Grunau, R.E. and Oberlander, T.F.

Erratum: Halothane and cardiac autonomic control in infants: Assessment with quantitative respiratory sinus arrhythmia (Pediatric Research (1996) 40 (710-717))

Pediatric Research

Oberlander, T.F.

Halothane and cardiac autonomic control in infants: Assessment with quantitative respiratory sinus arrhythmia

Pediatric Research

Oberlander, T.F. and Berde, C.B. and Saul, J.P.

DOI: 10.1203/00006450-199611000-00010

Time and frequency domain methods for heart rate variability analysis: A methodological comparison

Psychophysiology

LITVACK, D.A. and OBERLANDER, T.F. and CARNEY, L.H. and SAUL, J.P.

DOI: 10.1111/j.1469-8986.1995.tb02101.x

Infants tolerate spinal anesthesia with minimal overall autonomic changes: Analysis of heart rate variability in former premature infants undergoing hernia repair

Anesthesia and Analgesia

Oberlander, T.F. and Berde, C.B. and Lam, K.H. and Rappaport, L.A. and Saul, J.P.

DOI: 10.1097/00000539-199501000-00005

EFFECTS OF INTRA-ORAL SUCROSE ON CRYING, MOUTHING AND HAND-MOUTH CONTACT IN NEWBORN AND SIX-WEEK-OLD INFANTS

Developmental Medicine & Child Neurology

Barr, R.G. and Quek, V.S.H. and Cousineau, D. and Oberlander, T.F. and Brian, J.A. and Young, S.N.

DOI: 10.1111/j.1469-8749.1994.tb11898.x

Recurrent abdominal pain: evaluation and management

International Seminars in Paediatric Gastroenterology and Nutrition

Oberlander T, Rappaport L. Recurrent abdominal pain: evaluation and management. International Seminars in Paediatric Gastroenterology and Nutrition. 1994; 3(2):2-9.

Recurrent abdominal pain during childhood.

Pediatrics in review / American Academy of Pediatrics

Oberlander, T.F. and Rappaport, L.A.

DOI: 10.1542/pir.14-8-313

Advice Seeking and Appropriate Use of a Pediatric Emergency Department

American Journal of Diseases of Children

Oberlander, T.F. and Pless, I.B. and Dougherty, G.E.

DOI: 10.1001/archpedi.1993.02160320065021

Short-term effects of feed composition on sleeping and crying in newborns

Pediatrics

Oberlander, T.F. and Barr, R.G. and Young, S.N. and Brian, J.A.

Current Projects

My research extends from studies of child behaviour at the individual to population levels that seeks to understand how in utero exposure to maternal mood and selective serotonin reuptake inhibitor (SSRI) antidepressants sets pathways for both developmental risk and resiliency during early childhood. My work provides strong evidence that both influences have an impact on stress regulation and mood in childhood, possibly reflecting early changes in central serotonin (5HT) levels.

Increasingly my work is showing that the developing brain has a remarkable capacity for change, such that even in the face of adversity, some children do very well. The goal of my work is to figure out how and why this happens, and use these findings to identify opportunities for interventions that reduce risk. Emerging findings are beginning to point to ways that could possibly assist clinicians and families in understanding critical issues that influence a child’s emotional well-being and academic success later in school. As Project Lead for CFRI’s 3T MR Imaging facility I have the opportunity to advance studies of early brain development using advance imaging technology.

I have three main areas of research:

Developmental effects of prenatal psychotropic medication exposure – fetal, neonatal, infant and childhood outcomes: This research focuses on studies of the developmental impact of prenatal exposure to psychotropic medications (i.e. selective serotonin reuptake inhibitor [SSRI] antidepressants) and depressed maternal mood that extends from fetal periods to early adolescence. Biobehavioural, pharmacologic and genetic factors that moderate fetal exposure are studied. Outcomes of particular interest are pain/stress reactivity (neuroendocrine, heart variability), cognitive function (executive functions), attention threat bias, and measures of arousal and emotional regulation. This work also includes examination of the role of key genetic (i.e. SLC6A4) variations and epigenetic (i.e. methylation) factors that may also contribute to altered early serotonin levels.

Pharmacoepidemiology and Child Development: Since 2004 we have used population level health data linking antenatal maternal prescription records with birth/neonatal health records to distinguish the impact of maternal mood from in utero SSRI exposure. We have reported novel findings indicting that the effects of gestational maternal SSRI use differ from those of maternal mental illness and that neonatal outcomes vary with the timing and duration of prenatal SSRI exposure. Recently, we have started examining developmental and behavioural outcomes (learning, mood and autism spectrum disorder risk, ASD) related to in utero SSRI exposure, socioeconomic conditions and maternal mental health.

Pain and children with developmental disabilities: This research seeks to understand pain in children with developmental disabilities. The current focus of this work is to improve pain assessment management among this population of children.

Research Methodology
Fetal, neonatal and child behavioural state regulation
Non invasive stress measures (cardiac autonomic (RSA, PEP), salivary alpha-amylase & cortisol)
Integration of genetic and epigenetic factors to study interactions reflecting the impact of early experience
Population-based linked child health data

Grants

CIHR Operating Grant - Project: "Attention bias and executive functions in 9-14 year olds following prenatal antidepressant exposure" (2014-2019)

CIHR Operating Grant - Project: "Developmental origins of autism: A population level linked data study of prenatal antidepressant medication exposure" (2014-2017)

CIHR Operating Grant - Project: "Early child behavior: Relations to early brain development and maternal mood" (2012-2017)

Honours & Awards

Early Career UBC Scholar, The Peter Wall Institute for Advanced Studies, UBC (2003-2004)

Human Early Learning Partnership, Senior Scholar Award (2002-2005)

R. Howard Webster Professor in Early Childhood Development (2004-present)

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