Overview

I am a developmental pediatrician studying how early social experience (prenatal maternal mental illness and psychotropic medication exposure) influences the developmental origins of stress and self-regulation and its impact on thinking, learning and behaviour during childhood.

Publications

Perinatal selective serotonin reuptake inhibitor (SSRI) effects on body weight at birth and beyond: A review of animal and human studies
Reproductive Toxicology
Sarah M. Hutchison and Louise C. Mâsse and Jodi L. Pawluski and Tim F. Oberlander
DOI: 10.1016/j.reprotox.2018.02.004
04/2018

Perinatal selective serotonin reuptake inhibitor medication (SSRI) effects on social behaviors, neurodevelopment and the epigenome
Neuroscience & Biobehavioral Reviews
Mary Gemmel and Eszter Bögi and Christina Ragan and Mariah Hazlett and Michal Dubovicky and Daniel L. van den Hove and Tim F. Oberlander and Thierry D. Charlier and Jodi L. Pawluski
DOI: 10.1016/j.neubiorev.2017.04.023
02/2018

Maternal depression trajectories from pregnancy to 3 years postpartum are associated with children’s behavior and executive functions at 3 and 6 years
Archives of Women's Mental Health
Mina Park and Ursula Brain and Ruth E. Grunau and Adele Diamond and Tim F. Oberlander
DOI: 10.1007/s00737-017-0803-0
01/2018

Depressed Women of Low Socioeconomic Status Have High Numbers of Physician Visits in the Year Before Pregnancy: Implications for Care
Journal of Clinical Medicine Research
Jenny Fairthorne and Gillian E. Hanley and Tim F. Oberlander
DOI: 10.14740/jocmr3377w
2018

Unpacking the Heterogeneity of Cognitive Functioning in Children and Adolescents with Fetal Alcohol Spectrum Disorder: Determining the Role of Moderators and Strengths
Advances in Neurodevelopmental Disorders
Kaitlyn McLachlan and Angelina Paolozza and Katrina Kully-Martens and Elodie Portales-Casamar and Paul Pavlidis and Gail Andrew and Ana Hanlon-Dearman and Christine Loock and Audrey McFarlane and Sarah M. Nikkel and Jacqueline Pei and Tim F. Oberlander and Dawa Samdup and James N. Reynolds and Carmen Rasmussen
DOI: 10.1007/s41252-017-0034-4
09/2017

Response to “use of domperidone and risk of ventricular arrhythmia in the postpartum period: Getting to the heart of the matter”
Pharmacoepidemiology and Drug Safety
Kate Smolina and Steve Morgan and Barbara Mintzes and Gillian Hanley and Tim Oberlander
DOI: 10.1002/pds.4229
07/2017

Variations in Neurodevelopmental Outcomes in Children with Prenatal SSRI Antidepressant Exposure
Birth Defects Research
Naama Rotem-Kohavi and Tim F. Oberlander
DOI: 10.1002/bdr2.1076
07/2017

Infants and adults have similar regional functional brain organization for the perception of emotions
Neuroscience Letters
N. Rotem-Kohavi and T.F. Oberlander and N. Virji-Babul
DOI: 10.1016/j.neulet.2017.04.031
05/2017

Afternoon cortisol provides a link between self-regulated anger and peer-reported aggression in typically developing children in the school context
Developmental Psychobiology
Eva Oberle and Kaitlyn McLachlan and Nicole L.A. Catherine and Ursula Brain and Kimberly A. Schonert-Reichl and Joanne Weinberg and Tim F. Oberlander
DOI: 10.1002/dev.21522
05/2017

Disentangling Maternal Depression and Antidepressant Use During Pregnancy as Risks for Autism in Children
JAMA
Tim F. Oberlander and Lonnie Zwaigenbaum
DOI: 10.1001/jama.2017.3414
04/2017

The Risk of Teenage Motherhood Decreases in A Dose Response Fashion With Increasing SES: A Population-Based Study From British Columbia, Canada
JWHG
Jenny Fairthorne
DOI: 10.17303/jwhg.2017.4.104
03/2017

Antenatal exposure to antidepressants is associated with altered brain development in very preterm-born neonates
Neuroscience
Samantha K. Podrebarac and Emma G. Duerden and Vann Chau and Ruth E. Grunau and Anne Synnes and Tim F. Oberlander and Steven P. Miller
DOI: 10.1016/j.neuroscience.2016.11.025
02/2017

Developmental changes in serotonin signaling: Implications for early brain function, behavior and adaptation
Neuroscience
S. Brummelte and E. Mc Glanaghy and A. Bonnin and T.F. Oberlander
DOI: 10.1016/j.neuroscience.2016.02.037
02/2017

Variations from morning to afternoon of middle cerebral and umbilical artery blood flow, and fetal heart rate variability, and fetal characteristics in the normally developing fetus
Journal of Clinical Ultrasound
Tehila Avitan and Ari Sanders and Ursula Brain and Dan Rurak and Tim F Oberlander and Ken Lim
DOI: 10.1002/jcu.22569
2017

Post-Partum Depression and Infant Crying Behavior
Encyclopedia on Early Childhood Development
2017

Developmental origins of self-regulation: Prenatal maternal stress and psychobiological development during childhood
Parental stress and early child development: Adaptive and maladaptive outcomes
2017

Children’s stress regulation mediates the association between depressed and/or anxious prenatal maternal mood and child executive functions for boys, but not girls
Development and Psychopathology
2017

Predictors of Recovery from Depression and Anxiety in Women: A Longitudinal Study from Childbirth to 6 Years
The Canadian Journal of Psychiatry
Radhika Shankar and Rinette Badker and Ursula Brain and Tim F. Oberlander and Shaila Misri
DOI: 10.1177/0706743716677725
11/2016

SLC6A4promoter region methylation and socio-emotional stress response in very preterm and full-term infants
Epigenomics
Rosario Montirosso and Livio Provenzi and Roberto Giorda and Monica Fumagalli and Francesco Morandi and Ida Sirgiovanni and Uberto Pozzoli and Ruth Grunau and Tim F Oberlander and Fabio Mosca and Renato Borgatti
DOI: 10.2217/epi-2016-0010
07/2016

Genetic variation in catechol-O-methyltransferase modifies effects of clonidine treatment in chronic fatigue syndrome
The Pharmacogenomics Journal
K T Hall and J Kossowsky and T F Oberlander and T J Kaptchuk and J P Saul and V B Wyller and E Fagermoen and D Sulheim and J Gjerstad and A Winger and K J Mukamal
DOI: 10.1038/tpj.2016.53
07/2016

Sculpting infant soothability: the role of prenatal SSRI antidepressant exposure and neonatalSLC6A4methylation status
Developmental Psychobiology
Maria A. Gartstein and Kaia V. Hookenson and Ursula Brain and Angela M. Devlin and Ruth E. Grunau and Tim F. Oberlander
DOI: 10.1002/dev.21414
06/2016

The association between domperidone and ventricular arrhythmia in the postpartum period
Pharmacoepidemiology and Drug Safety
Kate Smolina and Barbara Mintzes and Gillian E. Hanley and Tim F. Oberlander and Steven G. Morgan
DOI: 10.1002/pds.4035
06/2016

Dysregulation of the cortisol diurnal rhythm following prenatal alcohol exposure and early life adversity
Alcohol
Kaitlyn McLachlan and Carmen Rasmussen and Tim F. Oberlander and Christine Loock and Jacqueline Pei and Gail Andrew and James Reynolds and Joanne Weinberg
DOI: 10.1016/j.alcohol.2016.03.003
06/2016

Developmental Effects of Prenatal Selective Serotonin Reuptake Inhibitor Exposure in Perspective: Are We Comparing Apples to Apples?
Journal of the American Academy of Child & Adolescent Psychiatry
Tim F. Oberlander and Simone N. Vigod
DOI: 10.1016/j.jaac.2016.02.012
05/2016

Postpartum Hemorrhage and Use of Serotonin Reuptake Inhibitor Antidepressants in Pregnancy
Obstetrics & Gynecology
Gillian E. Hanley and Kate Smolina and Barbara Mintzes and Tim F. Oberlander and Steven G. Morgan
DOI: 10.1097/aog.0000000000001200
03/2016

A patient decision aid for antidepressant use in pregnancy: study protocol for a randomized controlled trial
Trials
Simone Vigod and Neesha Hussain-Shamsy and Sophie Grigoriadis and Louise M. Howard and Kelly Metcalfe and Tim F. Oberlander and Carrie Schram and Donna E. Stewart and Valerie H. Taylor and Cindy-Lee Dennis
DOI: 10.1186/s13063-016-1233-4
02/2016

Postpartum domperidone use in British Columbia: a retrospective cohort study
CMAJ Open
K. Smolina and S. G. Morgan and G. E. Hanley and T. F. Oberlander and B. Mintzes
DOI: 10.9778/cmajo.20150067
01/2016

Fetal Effects of In Utero Serotonin Reuptake Inhibitor (SRI) Antidepressant Exposure
Fetal Development
Gillian Hanley and Kaia Hookenson and Dan Rurak and Tim F. Oberlander
DOI: 10.1007/978-3-319-22023-9_18
2016

Pain
Health Care for People with Intellectual and Developmental Disabilities across the Lifespan
Chantel C. Barney and John L. Belew and Abraham J. Valkenburg and Frank J. Symons and Tim F. Oberlander
DOI: 10.1007/978-3-319-18096-0_143
2016

A randomized controlled trial of eye shields and earmuffs to reduce pain response of preterm infants
Journal of Neonatal Nursing
Marilyn Aita and Céline Goulet and Tim F. Oberlander and Laurie Snider and Celeste Johnston
DOI: 10.1016/j.jnn.2014.11.004
06/2015

Trends and Determinants of Prescription Drug Use during Pregnancy and Postpartum in British Columbia, 2002–2011: A Population-Based Cohort Study
PLOS ONE
Kate Smolina and Gillian E. Hanley and Barbara Mintzes and Tim F. Oberlander and Steve Morgan
DOI: 10.1371/journal.pone.0128312
05/2015

Prenatal exposure to serotonin reuptake inhibitor antidepressants and childhood behavior
Pediatric Research
Gillian E. Hanley and Ursula Brain and Tim F. Oberlander
DOI: 10.1038/pr.2015.77
04/2015

Prenatal antidepressant exposure associated with CYP2E1 DNA methylation change in neonates
Epigenetics
C{\'{e}}cile Gurnot and Ignacio Martin-Subero and Sarah M Mah and Whitney Weikum and Sarah J Goodman and Ursula Brain and Janet F Werker and Michael S Kobor and Manel Esteller and Tim F Oberlander and Takao K Hensch},title = {Prenatal antidepressant exposure associated {withCYP}2E1DNA methylation change in neonates},journal = {Epigenetics
DOI: 10.1080/15592294.2015.1026031
04/2015

Enhancing cognitive and social–emotional development through a simple-to-administer mindfulness-based school program for elementary school children: A randomized controlled trial.
Developmental Psychology
Kimberly A. Schonert-Reichl and Eva Oberle and Molly Stewart Lawlor and David Abbott and Kimberly Thomson and Tim F. Oberlander and Adele Diamond
DOI: 10.1037/a0038454
01/2015

Do We Know If They Work and If They Are Safe
The Science and Ethics of Antipsychotic Use in Children
Dean Elbe and Edel Mc Glanaghy and Tim F. Oberlander
DOI: 10.1016/b978-0-12-800016-8.00003-9
2015

The Impact of Maternal Positive and Negative Affect on Fetal Physiology and Diurnal Patterns
The Israel journal of psychiatry and related sciences
Hanley, Gillian and Rurak, Dan and Lim, Ken and Brain, Ursula and Oberlander, Tim
11/2014

Transcranial direct current stimulation (tDCS) for treatment of major depression during pregnancy: study protocol for a pilot randomized controlled trial
Trials
Simone Vigod and Cindy-Lee Dennis and Zafiris Daskalakis and Kellie Murphy and Joel Ray and Tim Oberlander and Sarah Somerton and Neesha Hussain-Shamsy and Daniel Blumberger
DOI: 10.1186/1745-6215-15-366
09/2014

The symphonic structure of childhood stress reactivity: Patterns of sympathetic, parasympathetic, and adrenocortical responses to psychological challenge
Development and Psychopathology
Jodi A. Quas and Ilona S. Yim and Tim F. Oberlander and David Nordstokke and Marilyn J. Essex and Jeffrey M. Armstrong and Nicole Bush and Jelena Obradovic and W. Thomas Boyce
DOI: 10.1017/s0954579414000480
06/2014

Evaluation of the Neurobehavioral Screening Tool in Children with Fetal Alcohol Spectrum Disorder (FASD)
Journal of Population Therapeutics and Clinical Pharmacology
PubMed: 24897061
05/2014

Rising antipsychotic prescriptions for children and youth: cross-sectoral solutions for a multimodal problem
Canadian Medical Association Journal
N. Di Pietro and J. Illes and for the Canadian Working Group on Antipsychotic Medications and Children
DOI: 10.1503/cmaj.131604
03/2014

The effect of perinatal exposures on the infant: Antidepressants and depression
Best Practice & Research Clinical Obstetrics & Gynaecology
Gillian E. Hanley and Tim F. Oberlander
DOI: 10.1016/j.bpobgyn.2013.09.001
01/2014

Pain in Children with Autism
Mental Health and Pain
Tim F. Oberlander and Lonnie K. Zeltzer
DOI: 10.1007/978-2-8178-0414-9_12
2014

Neonatal pain and COMT Val158Met genotype in relation to serotonin transporter (SLC6A4) promoter methylation in very preterm children at school age
Frontiers in Behavioral Neuroscience
Cecil M. Y. Chau and Manon Ranger and Dian Sulistyoningrum and Angela M. Devlin and Tim F. Oberlander and Ruth E. Grunau
DOI: 10.3389/fnbeh.2014.00409
2014

Maternal and Fetal Factors That Influence Prenatal Exposure to Selective Serotonin Reuptake Inhibitor Antidepressants
Psychopharmacology and Pregnancy
Alison K. Shea and Tuan-Anh Thi Nguyen and Ursula Brain and Dan Rurak and Tim F. Oberlander
DOI: 10.1007/978-3-642-54562-7_4
2014

Biomarkers of pain: physiological indices of pain reactivity in infants and children
Oxford Medicine Online
Susanne Brummelte and Tim F. Oberlander and Kenneth D. Craig
DOI: 10.1093/med/9780199642656.003.0038
11/2013

Infant developmental outcomes following prenatal exposure to antidepressants, and maternal depressed mood and positive affect
Early Human Development
Gillian E. Hanley and Ursula Brain and Tim F. Oberlander
DOI: 10.1016/j.earlhumdev.2012.12.012
08/2013

FACTORS IMPACTING DECISIONS TO DECLINE OR ADHERE TO ANTIDEPRESSANT MEDICATION IN PERINATAL WOMEN WITH MOOD AND ANXIETY DISORDERS
Depression and Anxiety
Shaila Misri and Andrea B. Eng and Jasmin Abizadeh and Ekin Blackwell and Alicia Spidel and Tim F. Oberlander
DOI: 10.1002/da.22137
06/2013

Pain in Children with Disabilities
Encyclopedia of Pain
Kenneth D. Craig and Tim F. Oberlander
DOI: 10.1007/978-3-642-28753-4_3090
2013

Physician Variability in Treating Pain and Irritability of Unknown Origin in Children with Severe Neurological Impairment
Pain Research and Management
Harold B Siden and Bruce C Carleton and Tim F Oberlander
DOI: 10.1155/2013/193937
2013

Prenatal serotonin reuptake inhibitor (SRI) antidepressant exposure and serotonin transporter promoter genotype (SLC6A4) influence executive functions at 6 years of age
Frontiers in Cellular Neuroscience
Whitney M. Weikum and Ursula Brain and Cecil M. Y. Chau and Ruth E. Grunau and W. Thomas Boyce and Adele Diamond and Tim F. Oberlander
DOI: 10.3389/fncel.2013.00180
2013

The impact of prenatal serotonin reuptake inhibitor (SRI) antidepressant exposure and maternal mood on mother–infant interactions at 3 months of age
Infant Behavior and Development
Whitney M. Weikum and Linda C. Mayes and Ruth E. Grunau and Ursula Brain and Tim F. Oberlander
DOI: 10.1016/j.infbeh.2013.04.001
2013

Reply to Klinger et al
Birth Defects Research Part A: Clinical and Molecular Teratology
Gillian E. Hanley and Tim F. Oberlander
DOI: 10.1002/bdra.23095
11/2012

Prenatal exposure to antidepressants and depressed maternal mood alter trajectory of infant speech perception
Proceedings of the National Academy of Sciences
W. M. Weikum and T. F. Oberlander and T. K. Hensch and J. F. Werker
DOI: 10.1073/pnas.1121263109
10/2012

Fetal Serotonin Reuptake Inhibitor Antidepressant Exposure: Maternal and Fetal Factors
The Canadian Journal of Psychiatry
Alison K Shea and Tim F Oberlander and Dan Rurak
DOI: 10.1177/070674371205700902
09/2012

A Tale of 2s: Optimizing Maternal—Child Health in the Context of Antenatal Maternal Depression and Antidepressant Use
The Canadian Journal of Psychiatry
Tim F Oberlander and Katherine L Wisner
DOI: 10.1177/070674371205700901
09/2012

Fetal Serotonin Signaling: Setting Pathways for Early Childhood Development and Behavior
Journal of Adolescent Health
Tim F. Oberlander
DOI: 10.1016/j.jadohealth.2012.04.009
08/2012

Third trimester fetal pulmonary artery Doppler blood flow velocity characteristics following prenatal selective serotonin reuptake inhibitor (SSRI) exposure
Early Human Development
Ken Lim and Ari Sanders and Ursula Brain and Wayne Riggs and Tim F. Oberlander and Dan Rurak
DOI: 10.1016/j.earlhumdev.2012.01.004
08/2012

Prenatal SSRI exposure alters neonatal corticosteroid binding globulin, infant cortisol levels, and emerging HPA function
Psychoneuroendocrinology
Jodi L. Pawluski and Ursula M. Brain and Caroline M. Underhill and Geoffrey L. Hammond and Tim F. Oberlander
DOI: 10.1016/j.psyneuen.2011.11.011
07/2012

Neurodevelopmental outcomes following prenatal exposure to serotonin reuptake inhibitor antidepressants: A “social teratogen” or moderator of developmental risk?
Birth Defects Research Part A: Clinical and Molecular Teratology
Gillian E. Hanley and Tim F. Oberlander
DOI: 10.1002/bdra.23032
06/2012

Antidepressant use during pregnancy and serotonin transporter genotype (SLC6A4) Affect newborn serum reelin levels
Developmental Psychobiology
S. Brummelte and L.A.M. Galea and A.M. Devlin and T.F. Oberlander
DOI: 10.1002/dev.21056
06/2012

Biopsychosocial determinants of treatment outcome for mood and anxiety disorders up to 8 months postpartum
Archives of Women's Mental Health
Shaila Misri and Gillian Albert and Jasmin Abizadeh and Kristin Kendrick and Diana Carter and Deirdre Ryan and Tim F. Oberlander
DOI: 10.1007/s00737-012-0288-9
06/2012

Afternoon Cortisol in Elementary School Classrooms: Associations with Peer and Teacher Support and Child Behavior
School Mental Health
Nicole L. A. Catherine and Kimberly A. Schonert-Reichl and Clyde Hertzman and Tim F. Oberlander
DOI: 10.1007/s12310-012-9076-y
05/2012

The Management of Depression During Pregnancy: A Report from the American Psychiatric Association and the American College of Obstetricians and Gynecologists
FOCUS
Kimberly A. Yonkers and Katherine L. Wisner and Donna E. Stewart and Tim F. Oberlander and Diana L. Dell and Nada Stotland and Susan Ramin and Linda Chaudron and Charles Lockwood
DOI: 10.1176/appi.focus.10.1.78
01/2012

Pediatric Analgesic Clinical Trial Designs, Measures, and Extrapolation: Report of an FDA Scientific Workshop
PEDIATRICS
C. B. Berde and G. A. Walco and E. J. Krane and K. J. S. Anand and J. V. Aranda and K. D. Craig and C. D. Dampier and J. C. Finkel and M. Grabois and C. Johnston and J. Lantos and A. Lebel and L. G. Maxwell and P. McGrath and T. F. Oberlander and L. E. Schanberg and B. Stevens and A. Taddio and C. L. von Baeyer and M. Yaster and W. T. Zempsky
DOI: 10.1542/peds.2010-3591
01/2012

Intervention Minimizing Preterm Infants’ Exposure to NICU Light and Noise
Clinical Nursing Research
Marilyn Aita and Celeste Johnston and Céline Goulet and Tim F. Oberlander and Laurie Snider
DOI: 10.1177/1054773812469223
2012

Frontal EEG/ERP correlates of attentional processes, cortisol and motivational states in adolescents from lower and higher socioeconomic status
Frontiers in Human Neuroscience
Amedeo D'Angiulli and Joanne Weinberg and Tim F. Oberlander and Ruth E. Grunau and Clyde Hertzman and Stefania Maggi
DOI: 10.3389/fnhum.2012.00306
2012

Antidepressant use in children and adolescents: Practice touch points to guide paediatricians
Paediatrics & Child Health
Tim F Oberlander and Anton R Miller
DOI: 10.1093/pch/16.9.549
11/2011

Does breastfeeding reduce acute procedural pain in preterm infants in the neonatal intensive care unit? A randomized clinical trial
Pain
Liisa Holsti and Timothy F. Oberlander and Rollin Brant
DOI: 10.1016/j.pain.2011.07.022
11/2011

Focused attention, heart rate deceleration, and cognitive development in preterm and full-term infants
Developmental Psychobiology
Julianne H. Petrie Thomas and Michael F. Whitfield and Tim F. Oberlander and Anne R. Synnes and Ruth E. Grunau
DOI: 10.1002/dev.20597
08/2011

Third Trimester Fetal Heart Rate and Doppler Middle Cerebral Artery Blood Flow Velocity Characteristics During Prenatal Selective Serotonin Reuptake Inhibitor Exposure
Pediatric Research
Dan Rurak and Ken Lim and Ari Sanders and Ursula Brain and Wayne Riggs and Tim F Oberlander
DOI: 10.1203/pdr.0b013e31821ba11a
07/2011

Pain in Individuals with Intellectual Disabilities
Clinical Pain Management
Tim F. Oberlander and Chantel C. Burkitt and Frank J. Symons
DOI: 10.1002/9781444329711.ch39
11/2010

Prenatal Exposure to Maternal Depressed Mood and the MTHFR C677T Variant Affect SLC6A4 Methylation in Infants at Birth
PLoS ONE
Angela M. Devlin and Ursula Brain and Jehannine Austin and Tim F. Oberlander
DOI: 10.1371/journal.pone.0012201
08/2010

Cortisol, Behavior, and Heart Rate Reactivity to Immunization Pain at 4 Months Corrected Age in Infants Born Very Preterm
The Clinical Journal of Pain
Ruth E. Grunau and Mai Thanh Tu and Michael F. Whitfield and Tim F. Oberlander and Joanne Weinberg and Wayne Yu and Paul Thiessen and Gisela Gosse and David Scheifele
DOI: 10.1097/ajp.0b013e3181e5bb00
07/2010

Prenatal Effects of Selective Serotonin Reuptake Inhibitor Antidepressants, Serotonin Transporter Promoter Genotype (SLC6A4), and Maternal Mood on Child Behavior at 3 Years of Age
Archives of Pediatrics & Adolescent Medicine
Tim F. Oberlander and Michael Papsdorf and Ursula M. Brain and Shaila Misri and Colin Ross and Ruth E. Grunau
DOI: 10.1001/archpediatrics.2010.51
05/2010

Physiological correlates of memory recall in infancy: Vagal tone, cortisol, and imitation in preterm and full-term infants at 6 months
Infant Behavior and Development
David W. Haley and Ruth E. Grunau and Joanne Weinberg and Adi Keidar and Tim F. Oberlander
DOI: 10.1016/j.infbeh.2009.10.007
04/2010

Prenatal Alcohol Exposure Alters Biobehavioral Reactivity to Pain in Newborns
Alcoholism: Clinical and Experimental Research
Tim F. Oberlander and Sandra W. Jacobson and Joanne Weinberg and Ruth E. Grunau and Christopher D. Molteno and Joseph L. Jacobson
DOI: 10.1111/j.1530-0277.2009.01137.x
04/2010

Antenatal Depression and Anxiety Affect Postpartum Parenting Stress: A Longitudinal, Prospective Study
The Canadian Journal of Psychiatry
Shaila Misri and Kristin Kendrick and Tim F Oberlander and Sandhaya Norris and Lianne Tomfohr and Hongbin Zhang and Ruth E Grunau
DOI: 10.1177/070674371005500405
04/2010

Sustained Neurobehavioral Effects of Exposure to SSRI Antidepressants During Development: Molecular to Clinical Evidence
Clinical Pharmacology & Therapeutics
T F Oberlander and J A Gingrich and M S Ansorge
DOI: 10.1038/clpt.2009.201
11/2009

A register study of the impact of stopping third trimester selective serotonin reuptake inhibitor exposure on neonatal health
Acta Psychiatrica Scandinavica
W. Warburton and C. Hertzman and T. F. Oberlander
DOI: 10.1111/j.1600-0447.2009.01490.x
10/2009

The management of depression during pregnancy: a report from the American Psychiatric Association and the American College of Obstetricians and Gynecologists
General Hospital Psychiatry
Kimberly A. Yonkers and Katherine L. Wisner and Donna E. Stewart and Tim F. Oberlander and Diana L. Dell and Nada Stotland and Susan Ramin and Linda Chaudron and Charles Lockwood
DOI: 10.1016/j.genhosppsych.2009.04.003
09/2009

Neonatal S100B Protein Levels After Prenatal Exposure to Selective Serotonin Reuptake Inhibitors
PEDIATRICS
J. L. Pawluski and L. A.M. Galea and U. Brain and M. Papsdorf and T. F. Oberlander
DOI: 10.1542/peds.2009-0442
09/2009

Caregiving behavior and interactions of prenatally depressed mothers (antidepressant-treated and non-antidepressant-treated) during newborn acute pain
Infant Mental Health Journal
Fay F. Warnock and Roger Bakeman and Kim Shearer and Shaila Misri and Tim Oberlander
DOI: 10.1002/imhj.20220
07/2009

Depression during pregnancy: the potential impact of increased risk for fetal aneuploidy on maternal mood
Clinical Genetics
C Hippman and TF Oberlander and WG Honer and S Misri and JC Austin
DOI: 10.1111/j.1399-0004.2008.01056.x
01/2009

Optimizing neurodevelopmental outcomes in infants and children following prenatal SSRI exposure
Pediatric Health
Tim F Oberlander
DOI: 10.2217/phe.09.56
2009

Contingency Learning and Reactivity in Preterm and Full-Term Infants at 3 Months
Infancy
David W. Haley and Ruth E. Grunau and Tim F. Oberlander and Joanne Weinberg
DOI: 10.1080/15250000802458682
11/2008

Effects of intra-oral sucrose on crying, mouthing and hand-mouth contact in newborn and six-week-old infants.
Developmental Medicine & Child Neurology
Ronald G. Barr and Vivien S. H. Quek and Dominique Cousineau and Tim F. Oberlander and Jessica A. Brian and Simon N. Young
DOI: 10.1111/j.1469-8749.1994.tb11898.x
11/2008

Hypothalamic–pituitary–adrenal (HPA) axis function in 3-month old infants with prenatal selective serotonin reuptake inhibitor (SSRI) antidepressant exposure
Early Human Development
Tim F. Oberlander and Ruth Grunau and Linda Mayes and Wayne Riggs and Dan Rurak and Michael Papsdorf and Shaila Misri and Joanne Weinberg
DOI: 10.1016/j.earlhumdev.2008.06.008
10/2008

Effects of timing and duration of gestational exposure to serotonin reuptake inhibitor antidepressants: Population-based study
British Journal of Psychiatry
Tim F. Oberlander and William Warburton and Shaila Misri and Jaafar Aghajanian and Clyde Hertzman
DOI: 10.1192/bjp.bp.107.037101
05/2008

Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses
Epigenetics
Tim F. Oberlander and Joanne Weinberg and Michael Papsdorf and Ruth Grunau and Shaila Misri and Angela M. Devlin
DOI: 10.4161/epi.3.2.6034
03/2008

Is It Painful or Not?
The Clinical Journal of Pain
Liisa Holsti and Ruth E. Grunau and Tim F. Oberlander and Horacio Osiovich
DOI: 10.1097/ajp.0b013e318158c5e5
01/2008

Pain Management for Children with a Developmental Disability in a Primary Care Setting
Pain in Children
Harold (Hal) Siden and Tim F. Oberlander
DOI: 10.1007/978-1-59745-476-6_4
2008

Major congenital malformations following prenatal exposure to serotonin reuptake inhibitors and benzodiazepines using population-based health data
Birth Defects Research Part B: Developmental and Reproductive Toxicology
Tim F. Oberlander and William Warburton and Shaila Misri and Wayne Riggs and Jaafar Aghajanian and Clyde Hertzman
DOI: 10.1002/bdrb.20144
2008

Neonatal Risks of Maternal Treatment With Mood Stabilizers—Reply
Archives of General Psychiatry
Tim F. Oberlander and William Warburton and Shaila Misri and Jaafar Aghajanian and Clyde Hertzman
DOI: 10.1001/archpsyc.64.7.867
07/2007

Infant serotonin transporter (SLC6A4) promoter genotype is associated with adverse neonatal outcomes after prenatal exposure to serotonin reuptake inhibitor medications
Molecular Psychiatry
T F Oberlander and R J Bonaguro and S Misri and M Papsdorf and C J D Ross and E M Simpson
DOI: 10.1038/sj.mp.4002007
05/2007

Toward comprehensive treatment for postpartum depressed mothers and their infants
BC Medical Journal
04/2007

‘Beliefs about pain among professionals working with children with significant neurologic impairment’
Developmental Medicine & Child Neurology
Tim F Oberlander and Maureen E O‘Donnell
DOI: 10.1111/j.1469-8749.2001.tb00734.x
02/2007

Cytochrome P4502D6 (CYP2D6) Gene Locus Heterogeneity: Characterization of Gene Duplication Events
Clinical Pharmacology & Therapeutics
A Gaedigk and L Ndjountché and K Divakaran and L DiAnne Bradford and I Zineh and T F Oberlander and D C Brousseau and D G McCarver and J A Johnson and S W Alander and K Wayne Riggs and J Steven Leeder
DOI: 10.1038/sj.clpt.6100033
02/2007

Biobehavioural reactivity to pain in preterm infants: a marker of neuromotor development
Developmental Medicine & Child Neurology
Ruth E Grunau and Michael F Whitfield and Taryn Fay and Liisa Holsti and Timothy Oberlander and Marilynn L Rogers
DOI: 10.1111/j.1469-8749.2006.tb01298.x
02/2007

Externalizing and Attentional Behaviors in Children of Depressed Mothers Treated With a Selective Serotonin Reuptake Inhibitor Antidepressant During Pregnancy
Archives of Pediatrics & Adolescent Medicine
Tim F. Oberlander and Pratibha Reebye and Shaila Misri and Michael Papsdorf and John Kim and Ruth E. Grunau
DOI: 10.1001/archpedi.161.1.22
01/2007

Pain in Children with Disabilities
Encyclopedia of Pain
Tim F. Oberlander and Kenneth D. Craig
DOI: 10.1007/978-3-540-29805-2_3090
2007

Behavioral Responses to Pain Are Heightened After Clustered Care in Preterm Infants Born Between 30 and 32 Weeks Gestational Age
The Clinical Journal of Pain
Liisa Holsti and Ruth E. Grunau and Michael F. Whifield and Tim F. Oberlander and Viveca Lindh
DOI: 10.1097/01.ajp.0000210921.10912.47
11/2006

A Prospective Controlled Study of Neurodevelopment in HIV-Uninfected Children Exposed to Combination Antiretroviral Drugs in Pregnancy
PEDIATRICS
A. Alimenti and J. C. Forbes and T. F. Oberlander and D. M. Money and R. E. Grunau and M. P. Papsdorf and E. Maan and L. J. Cole and D. R. Burdge
DOI: 10.1542/peds.2006-0525
10/2006

Biobehavioural reactivity to pain in preterm infants: A marker of neuromotor development
Acute Pain
R.E. Grunau and M.F. Whitfield and T. Fay and L. Holsti and T. Oberlander and M.L. Rogers
DOI: 10.1016/j.acpain.2006.08.033
10/2006

Neonatal Outcomes After Prenatal Exposure to Selective Serotonin Reuptake Inhibitor Antidepressants and Maternal Depression Using Population-Based Linked Health Data
Archives of General Psychiatry
Tim F. Oberlander and William Warburton and Shaila Misri and Jaafar Aghajanian and Clyde Hertzman
DOI: 10.1001/archpsyc.63.8.898
08/2006

Internalizing Behaviors in 4-Year-Old Children Exposed in Utero to Psychotropic Medications
American Journal of Psychiatry
Shaila Misri and Pratibha Reebye and Kristin Kendrick and Diana Carter and Deirdre Ryan and Ruth E. Grunau and Tim F. Oberlander
DOI: 10.1176/ajp.2006.163.6.1026
06/2006

Summary Proceedings From the Neonatal Pain-Control Group
Pediatrics
Kanwaljeet J.S. Anand and Jacob V. Aranda and Charles B. Berde and ShaAvhrée Buckman and Edmund V. Capparelli and Waldemar Carlo and Patricia Hummel and C. Celeste Johnston and John Lantos and Victoria Tutag-Lehr and Anne M. Lynn and Lynne G. Maxwell and Tim F. Oberlander and Tonse N.K. Raju and Sulpicio G. Soriano and Anna Taddio and Gary A. Walco
DOI: 10.1542/peds.2005-0620c
03/2006

Stereoselective disposition of fluoxetine and norfluoxetine during pregnancy and breast-feeding
British Journal of Clinical Pharmacology
John Kim and K. Wayne Riggs and Shaila Misri and Nancy Kent and Tim F. Oberlander and Ruth E. Grunau and Colleen Fitzgerald and Dan W. Rurak
DOI: 10.1111/j.1365-2125.2005.02538.x
02/2006

Body Movements: An Important Additional Factor in Discriminating Pain From Stress in Preterm Infants
The Clinical Journal of Pain
Liisa Holsti and Ruth E Grunau and Tim F Oberlander and Michael F Whitfield and Joanne Weinberg
DOI: 10.1097/01.ajp.0000146163.30776.44
11/2005

Analgesia and local anesthesia during invasive procedures in the neonate
Clinical Therapeutics
K.J.S. Anand and C. Celeste^Johnston and Tim F. Oberlander and Anna Taddio and Victoria Tutag Lehr and Gary A. Walco
DOI: 10.1016/j.clinthera.2005.06.018
06/2005

Prior pain induces heightened motor responses during clustered care in preterm infants in the NICU
Early Human Development
Liisa Holsti and Ruth E. Grunau and Tim F. Oberlander and Michael F. Whitfield
DOI: 10.1016/j.earlhumdev.2004.08.002
03/2005

Neonatal procedural pain exposure predicts lower cortisol and behavioral reactivity in preterm infants in the NICU
Pain
Ruth E. Grunau and Liisa Holsti and David W. Haley and Tim Oberlander and Joanne Weinberg and Alfonso Solimano and Michael F. Whitfield and Colleen Fitzgerald and Wayne Yu
DOI: 10.1016/j.pain.2004.10.020
02/2005

Pain Reactivity in 2-Month-Old Infants After Prenatal and Postnatal Serotonin Reuptake Inhibitor Medication Exposure
PEDIATRICS
T. F. Oberlander
DOI: 10.1542/peds.2004-0420
02/2005

Analgesia and anesthesia for neonates: Study design and ethical issues
Clinical Therapeutics
K.J.S. Anand and Jacob V. Aranda and Charles B. Berde and ShaAvhrée Buckman and Edmund V. Capparelli and Waldemar A. Carlo and Patricia Hummel and John Lantos and C. Celeste Johnston and Victoria Tutag Lehr and Anne M. Lynn and Lynne G. Maxwell and Tim F. Oberlander and Tonse N.K. Raju and Sulpicio G. Soriano and Anna Taddio and Gary A. Walco
DOI: https://doi.org/10.1016/j.clinthera.2005.06.021
2005

Relation between Prenatal Maternal Mood and Anxiety and Neonatal Health
The Canadian Journal of Psychiatry
Shaila Misri and Tim F Oberlander and Nichole Fairbrother and Diana Carter and Deirdre Ryan and Annie J Kuan and Pratibha Reebye
DOI: 10.1177/070674370404901006
10/2004

Specific Newborn Individualized Developmental Care and Assessment Program Movements Are Associated With Acute Pain in Preterm Infants in the Neonatal Intensive Care Unit
PEDIATRICS
L. Holsti
DOI: 10.1542/peds.114.1.65
07/2004

Expression of Pain in Children With Autism
The Clinical Journal of Pain
Rami Nader and Tim F. Oberlander and Christine T. Chambers and Kenneth D. Craig
DOI: 10.1097/00002508-200403000-00005
03/2004

Does Prone or Supine Position Influence Pain Responses in Preterm Infants at 32 Weeks Gestational Age?
The Clinical Journal of Pain
Ruth Eckstein Grunau and Maria Beatriz Martins Linhares and Liisa Holsti and Tim F. Oberlander and Michael F. Whitfield
DOI: 10.1097/00002508-200403000-00003
03/2004

Pharmacologic Factors Associated With Transient Neonatal Symptoms Following Prenatal Psychotropic Medication Exposure
The Journal of Clinical Psychiatry
Tim F. Oberlander and Shaila Misri and Colleen E. Fitzgerald and Xanthoula Kostaras and Dan Rurak and Wayne Riggs
DOI: 10.4088/jcp.v65n0214
02/2004

Are there developmentally distinct motor indicators of pain in preterm infants?
Early Human Development
Sara J Morison and Liisa Holsti and Ruth Eckstein Grunau and Michael F Whitfield and Tim F Oberlander and Herbert W.P Chan and Linda Williams
DOI: 10.1016/s0378-3782(03)00044-6
06/2003

Methodological considerations for the use of heart rate variability as a measure of pain reactivity in vulnerable infants
Clinics in Perinatology
Tim Oberlander and J.Philip Saul
DOI: 10.1016/s0095-5108(02)00013-1
09/2002

Does Parenchymal Brain Injury Affect Biobehavioral Pain Responses in Very Low Birth Weight Infants at 32 Weeks' Postconceptional Age?
PEDIATRICS
T. F. Oberlander and R. E. Grunau and C. Fitzgerald and M. F. Whitfield
DOI: 10.1542/peds.110.3.570
09/2002

Prolonged Prenatal Psychotropic Medication Exposure Alters Neonatal Acute Pain Response
Pediatric Research
Tim F Oberlander and Ruth Eckstein Grunau and Colleen Fitzgerald and Ann-Louise Ellwood and Shaila Misri and Dan Rurak and Kenneth Wayne Riggs
DOI: 10.1203/00006450-200204000-00008
04/2002

Pain Assessment and Management in Infants and Young Children with Developmental Disabilities
Infants & Young Children
Tim F. Oberlander
DOI: 10.1097/00001163-200114020-00006
10/2001

Demographic and Therapeutic Determinants of Pain Reactivity in Very Low Birth Weight Neonates at 32 Weeks' Postconceptional Age
PEDIATRICS
R. E. Grunau and T. F. Oberlander and M. F. Whitfield and C. Fitzgerald and S. K. Lee
DOI: 10.1542/peds.107.1.105
01/2001

Pain reactivity in former extremely low birth weight infants at corrected age 8 months compared with term born controls
Infant Behavior and Development
Ruth Eckstein Grunau and Tim F. Oberlander and Michael F. Whitfield and Colleen Fitzgerald and Sara J. Morison and J. Philip Saul
DOI: 10.1016/s0163-6383(01)00065-0
01/2001

Relations Between Behavioral and Cardiac Autonomic Reactivity to Acute Pain in Preterm Neonates
The Clinical Journal of Pain
Sara J. Morison and Ruth E. Grunau and Tim F. Oberlander and Michael F. Whitfield
DOI: 10.1097/00002508-200112000-00010
2001

Prenatal and Breast Milk Morphine Exposure Following Maternal Intrathecal Morphine Treatment
Journal of Human Lactation
Tim F. Oberlander and Paula Robeson and Val Ward and R. Stuart Huckin and A. Kamani and Arthur Harpur and William McDonald
DOI: 10.1177/089033440001600210
05/2000

Biobehavioral Pain Responses in Former Extremely Low Birth Weight Infants at Four Months' Corrected Age
Pediatrics
Tim F. Oberlander and Ruth Eckstein Grunau and Michael F. Whitfield and Colleen Fitzgerald and Sandy Pitfield and J. Philip Saul
DOI: 10.1542/peds.105.1.e6
01/2000

Evaluating Treatment Outcome in an Interdisciplinary Pediatric Pain Service
Pain Research and Management
Susan M Bennett and Christine T Chambers and Doria Bellows and Colleen A Court and Elizabeth Huntsman and Carolyne Montgomery and Tim F Oberlander and Michelle Sheriff and Harold Siden
DOI: 10.1155/2000/767058
2000

Pain Management of Junctional Epidermolysis Bullosa in an 11-Year-Old Boy
Pediatric Dermatology
Yao-Kun Chiu and Julie S. Prendiville and Susan M. Bennett and Carolyne J. Montgomery and Tim F. Oberlander
DOI: 10.1046/j.1525-1470.1999.00120.x
11/1999

Biobehavioral Responses to Acute Pain in Adolescents with a Significant Neurologic Impairment
The Clinical Journal of Pain
Tim F. Oberlander and Cheryl A. Gilbert and Christine T. Chambers and Maureen E. O'Donnell and Kenneth D. Craig
DOI: 10.1097/00002508-199909000-00007
09/1999

Pain in Children with Significant Neurological Impairment
Journal of Developmental & Behavioral Pediatrics
TIM F. OBERLANDER and MAUREEN E. O'DONNELL and CAROLYNE J. MONTGOMERY
DOI: 10.1097/00004703-199908000-00006
08/1999

The Developmental Character of Cardiac Autonomic Responses to an Acute Noxious Event in 4- and 8-Month-Old Healthy Infants
Pediatric Research
Tim F Oberlander and Ruth Eckstein Grunau and Sandy Pitfield and Michael F Whitfield and J Philip Saul
DOI: 10.1203/00006450-199904010-00011
04/1999

Bedside application of the Neonatal Facial Coding System in pain assessment of premature infants
Pain
Ruth Eckstein Grunau and Tim Oberlander and Liisa Holsti and Michael F. Whitfield
DOI: 10.1016/s0304-3959(98)00046-3
06/1998

Cardiac Autonomic and Behavioral Responses to Acute Pain in 4 Month Old Infants † 80
Pediatric Research
Tim F. Oberlander and Ruth V.E. Grunau and Micheal F. Whitfield and J. Philip Saul
DOI: 10.1203/00006450-199704001-00101
04/1997

Developmental character and long-term consequences of pain in infants and children
Child and Adolescent Psychiatric Clinics of North America
Anand, Kanwaljeet and Grunau, Ruth and Oberlander, Tim
01/1997

Halothane and Cardiac Autonomic Control in Infants: Assessment with Quantitative Respiratory Sinus Arrhythmia
Pediatric Research
Tim F Oberlander and C B Berde and J Philip Saul
DOI: 10.1203/00006450-199611000-00010
11/1996

Time and frequency domain methods for heart rate variability analysis: A methodological comparison
Psychophysiology
DANIEL A. LITVACK and TIM F. OBERLANDER and LAUREL H. CARNEY and J. PHILIP SAUL
DOI: 10.1111/j.1469-8986.1995.tb02101.x
09/1995

Infants Tolerate Spinal Anesthesia with Minimal Overall Autonomic Changes
Anesthesia & Analgesia
Tim F. Oberlander and Charles B. Berde and Kar H. Lam and L. A. Rappaport and J. Philip Saul
DOI: 10.1097/00000539-199501000-00005
01/1995

Recurrent abdominal pain: evaluation and management
International Seminars in Paediatric Gastroenterology and Nutrition
1994

Recurrent Abdominal Pain During Childhood
Pediatrics in Review
T. F. Oberlander and L. A. Rappaport
DOI: 10.1542/pir.14-8-313
08/1993

Advice Seeking and Appropriate Use of a Pediatric Emergency Department
Archives of Pediatrics & Adolescent Medicine
T. F. Oberlander
DOI: 10.1001/archpedi.1993.02160320065021
08/1993

Short-term Effects of Feed Composition on Sleeping and Crying in Newborns
Pediatrics
Oberlander, Tim F. and Barr, Ronald G. and Young, Simon N. and Brian, Jessica A.
1992

Research

Current Projects
My research extends from studies of child behaviour at the individual to population levels that seeks to understand how in utero exposure to maternal mood and selective serotonin reuptake inhibitor (SSRI) antidepressants sets pathways for both developmental risk and resiliency during early childhood. My work provides strong evidence that both influences have an impact on stress regulation and mood in childhood, possibly reflecting early changes in central serotonin (5HT) levels.

Increasingly my work is showing that the developing brain has a remarkable capacity for change, such that even in the face of adversity, some children do very well. The goal of my work is to figure out how and why this happens, and use these findings to identify opportunities for interventions that reduce risk. Emerging findings are beginning to point to ways that could possibly assist clinicians and families in understanding critical issues that influence a child’s emotional well-being and academic success later in school. As Project Lead for CFRI’s 3T MR Imaging facility I have the opportunity to advance studies of early brain development using advance imaging technology.

I have three main areas of research:

Developmental effects of prenatal psychotropic medication exposure – fetal, neonatal, infant and childhood outcomes: This research focuses on studies of the developmental impact of prenatal exposure to psychotropic medications (i.e. selective serotonin reuptake inhibitor [SSRI] antidepressants) and depressed maternal mood that extends from fetal periods to early adolescence. Biobehavioural, pharmacologic and genetic factors that moderate fetal exposure are studied. Outcomes of particular interest are pain/stress reactivity (neuroendocrine, heart variability), cognitive function (executive functions), attention threat bias, and measures of arousal and emotional regulation. This work also includes examination of the role of key genetic (i.e. SLC6A4) variations and epigenetic (i.e. methylation) factors that may also contribute to altered early serotonin levels.

Pharmacoepidemiology and Child Development: Since 2004 we have used population level health data linking antenatal maternal prescription records with birth/neonatal health records to distinguish the impact of maternal mood from in utero SSRI exposure. We have reported novel findings indicting that the effects of gestational maternal SSRI use differ from those of maternal mental illness and that neonatal outcomes vary with the timing and duration of prenatal SSRI exposure. Recently, we have started examining developmental and behavioural outcomes (learning, mood and autism spectrum disorder risk, ASD) related to in utero SSRI exposure, socioeconomic conditions and maternal mental health.

Pain and children with developmental disabilities: This research seeks to understand pain in children with developmental disabilities. The current focus of this work is to improve pain assessment management among this population of children.

Research Methodology
Fetal, neonatal and child behavioural state regulation
Non invasive stress measures (cardiac autonomic (RSA, PEP), salivary alpha-amylase & cortisol)
Integration of genetic and epigenetic factors to study interactions reflecting the impact of early experience
Population-based linked child health data

Grants

CIHR Operating Grant - Project: "Attention bias and executive functions in 9-14 year olds following prenatal antidepressant exposure" (2014-2019)

CIHR Operating Grant - Project: "Developmental origins of autism: A population level linked data study of prenatal antidepressant medication exposure" (2014-2017)

CIHR Operating Grant - Project: "Early child behavior: Relations to early brain development and maternal mood" (2012-2017)

Honours & Awards

Early Career UBC Scholar, The Peter Wall Institute for Advanced Studies, UBC (2003-2004)

Human Early Learning Partnership, Senior Scholar Award (2002-2005)

R. Howard Webster Professor in Early Childhood Development (2004-present)

Research Group Members

Ursula Brain, Research Manager, Healthy Starts Program
Dawna Brown
Amanda Chao
Marie-Noelle Wharton
Radhika Shankar
Alicia Tonello
Angie Ip
Kayleigh Campbell, PhD Candidate
Mina Park
Meghna Rajaprakash
Ella Weik
Jada Holmes
Naama Rotem-Kohavi
Heather Beveridge, Research Asst/Tech 1 (Complex Care)
Elizabeth Scott
Colleen Pawliuk
Sarah Hutchison, Postdoctoral Fellow
Tamara Bodnar, Postdoctoral fellow
Amanda Chao, Research Assistant
Wayne Yu, Lab manager