My areas of research interest lies within the area of pediatric drug allergy. Many patients labelled as allergic to medications are not actually allergic – this has significant impact on medication selection for subsequent illnesses, and leads to less optimal medication being prescribed to the patient at increased costs to the health care system. This is of particular concern in patients with complex medical needs who often require admission to hospital or treatment with medications. I hope that by developing a program aimed at clarifying the nature of reactions and de-labeling allergy, we can optimize medication selection and patient care, both in hospital and in the community.

I am also involved in projects involving a variety of aspects of food allergy, including optimizing management of allergic reactions by patients/families and describing unusual cases of food allergy in pediatrics.


Impact of supervised epinephrine autoinjector administration during food challenges on parent confidence
Annals of Allergy, Asthma & Immunology
Timothy Teoh, Christopher Mill, Tiffany Wong, Ingrid Baerg, Angela Alexander, Kyla J. Hildebrand, John Dean, Boris Kuzeljevic, Edmond S. Chan
DOI: 10.1016/j.anai.2016.02.020

Combined Autoimmune Cytopenias Presenting in ChildhoodCombined Autoimmune Cytopenias in Childhood
Pediatr Blood Cancer
Ibrahim Al Ghaithi, Nicola A.M. Wright, Vicky R. Breakey, Kelly Cox, Ashley Warias, Tiffany Wong, Colleen O'Connell, Victoria Price
DOI: 10.1002/pbc.25769

IgE-Mediated allergy to wheat in a child with celiac disease – a case report
Allergy, Asthma & Clinical Immunology
Tiffany Wong, Hin Ko, Edmond S Chan
DOI: 10.1186/1710-1492-10-56

Epinephrine auto injector administration by parents or patients for anaphylaxis during supervised oral food challenges and assessment of confidence
Allergy, Asthma & Clinical Immunology
Ingrid Baerg, Angela Alexander, Tiffany Wong, Timothy Teoh, Kyla Hildebrand, Sara Leo, Joanne Yeung, John Dean, Edmond Chan
DOI: 10.1186/1710-1492-10-s2-a2

IgE Mediated allergy to wheat in a child with celiac disease
Allergy, Asthma & Clinical Immunology
Tiffany Wong, Edmond S Chan
DOI: 10.1186/1710-1492-10-s1-a37

Combined and alternating paracetamol and ibuprofen therapy for febrile children
Cochrane Database of Systematic Reviews
Tiffany Wong, Antonia S Stang, Heather Ganshorn, Lisa Hartling, Ian K Maconochie, Anna M Thomsen, David W Johnson
DOI: 10.1002/14651858.cd009572.pub2

Delayed Introduction of Food and Effect On Incidence of Food Allergy in a Population At High Risk for Atopy: The Canadian Asthma Primary Prevention Study (CAPPS)
Journal of Allergy and Clinical Immunology
Tiffany Wong, Moira Chan-Yeung, Roxanne Rousseau, Anne Dybuncio, Anita L. Kozyrskyj, Clare Ramsey, Allan Becker, Edmond S. Chan
DOI: 10.1016/j.jaci.2012.12.1013

Human primary immunodeficiencies causing defects in innate immunity
Current Opinion in Allergy and Clinical Immunology
Tiffany Wong, Joanne Yeung, Kyla J. Hildebrand, Anne K. Junker, Stuart E. Turvey
DOI: 10.1097/aci.0000000000000010

Combined and alternating paracetamol and ibuprofen therapy for fever in children
Cochrane Database of Systematic Reviews
Tiffany Wong, David W Johnson, Heather Ganshorn, Ian K Maconochie, Lisa Hartling, Antonia S. Stang
DOI: 10.1002/14651858.cd009572

Outcome of diagnostic intervention predicts health-related quality of life scores among children with food allergy
Allergy, Asthma & Clinical Immunology
Linda Kirste, Tim K Takaro, Boris Kuzeljevic, Tiffany Wong, Edmond S Chan
DOI: 10.1186/1710-1492-8-s1-a9

The impact of ongoing illicit drug use on methadone adherence in illicit drug users receiving treatment for HIV in a directly observed therapy program
Drug and Alcohol Dependence
Jesse D. Raffa, Jason Grebely, Harout Tossonian, Tiffany Wong, Mark Viljoen, Milan Khara, Annabel Mead, Mark McLean, Fiona Duncan, A. John Petkau
DOI: 10.1016/j.drugalcdep.2007.02.007

Competitive Displacement of Clozapine from Plasma Proteins in Normolipidemic and Hyperlipidemic Plasma Samples: Clinical Implications
Ric Procyshyn, Tiffany Ho, Kishor Wasan
DOI: 10.1081/ddc-200054305

The Effects of Competitive Displacement on Haloperidol's Plasma Distribution in Normolipidemic and Hyperlipidemic Plasma
Drug Development and Industrial Pharmacy
Ric M. Procyshyn, Tiffany Ho, Kishor M. Wasan
DOI: 10.1080/03639040500272058


Epinephrine Autoinjector Study
Families in Pediatric Allergy Clinic often report that they are fearful of using an epinephrine autoinjector despite receiving education on indications for use and technique. It is very important that patients and caregivers have the skills, knowledge and confidence to administer the epinephrine autoinjector when indicated. The goal of this study is to assess the impact of self or caregiver-administrated epinephrine in a medically supervised setting on the confidence of patient and/or caregivers for future use of epinephrine autoinjector.

Penicillin de-labelling Study:
Penicillin allergy is a common drug allergy diagnosis. However, upon assessment by Allergists, many people are not actually allergic. Patients can be erroneously labelled as allergic due to misclassification of a suspected reaction. As a result, many patients will receive alternative antibiotics that are more expensive, potentially less effective, more toxic, and may increase risk of antibiotic resistance. The goal of this study is to develop assessment tools and a program to help pediatric health care providers identify those who are at low risk of penicillin allergy and de-label them.

Research Group Members

Lisa Wilson, Clinic Secretary