Scientists have developed a molecular “clock” that could reshape how pediatricians measure and monitor childhood growth and potentially allow for an earlier diagnosis of life-altering development disorders. The research, published this week in PNAS, describes how the addition of chemical tags to DNA over time can potentially be used to screen for developmental differences and health problems in children.
I am interested in how the clinical laboratory impacts pediatric and perinatal healthcare and outcomes. My research interests span areas of laboratory medicine that impact test use, interpretation and quality, including laboratory quality improvement; optimizing laboratory test utilization; improving test interpretation; and developing, improving and characterizing laboratory testing methods.
Quantitative mass spectrometry reveals changes in SNAP-25 isoforms in schizophrenia.
Barakauskas VE and Moradian A and Barr AM and Beasley CL and Rosoklija G and Mann JJ and Ilievski B and Stankov A and Dwork AJ and Falkai P and Morin GB and Honer WG
Process Optimization to Improve Immunosuppressant Drug Testing Turnaround Time.
Barakauskas VE and Bradshaw TA and Smith LD and Lehman CM and Johnson-Davis KL
Identification of Hb Wayne and its effects on HbA1c measurement by 5 methods.
Rodríguez-Capote K and Estey MP and Barakauskas VE and Burton T and Holmes D and Krause R and Higgins TN
Erroneous diabetes diagnosis: a case of HbA1c interference.
Turley E and Rodríguez-Capote K and Estey MP and Barakauskas VE and Bailey GR and McKenzie LM and Higgins TN
Hemoglobin C in a patient with sickle cell anemia: transfusion-acquired SC disease.
Estey MP and Capote KR and Barakauskas VE and Clarke G and Higgins T
Effects of haloperidol and clozapine administration on oxidative stress in rat brain, liver and serum.
Andreazza AC and Barakauskas VE and Fazeli S and Feresten A and Shao L and Wei V and Wu CH and Barr AM and Beasley CL
Increased expression of glial fibrillary acidic protein in prefrontal cortex in psychotic illness.
Feresten AH and Barakauskas V and Ypsilanti A and Barr AM and Beasley CL
Effects of sub-chronic clozapine and haloperidol administration on brain lipid levels.
Barakauskas VE and Ypsilanti AR and Barr AM and Innis SM and Honer WG and Beasley CL
Pregnancy decreases oestrogen receptor alpha expression and pyknosis, but not cell proliferation or survival, in the hippocampus.
Pawluski JL and Barakauskas VE and Galea LA
A novel mechanism and treatment target for presynaptic abnormalities in specific striatal regions in schizophrenia.
Barakauskas VE and Beasley CL and Barr AM and Ypsilanti AR and Li HY and Thornton AE and Wong H and Rosokilja G and Mann JJ and Mancevski B and Jakovski Z and Davceva N and Ilievski B and Dwork AJ and Falkai P and Honer WG
I am interested in laboratory quality improvement, optimization of test utilization and interpretation, as well as clinical laboratory method development and validation for application to pediatric and maternity care.
I am currently working to characterize the performance of analytical methods available at C&W for body fluid testing. In a hospital setting, body fluid testing (for example, pleural and peritoneal fluids or CSF) can aid in diagnosis and patient management.
I am also working towards improving laboratory test interpretation during pregnancy. Currently, results of laboratory tests for pregnant women are compared to reference intervals for non-pregnant females. Significant physiological changes occur during pregnancy which can change blood chemistry parameters. While these changes are a normal part of pregnancy, they may be wrongly interpretted and result in inappropriate treatment or follow-up. This may adversely impact both mothers and babies, as well as impacting the health care system. Appropriate reference ranges for women during pregnancy are required to make appropriate clinical care decisions. My aim is to inform, update and produce pregnancy-specific reference intervals, which will improve maternal health care in Canada.Honours & Awards
2004-2005 CIHR/MSFHR Strategic Training Program in Neurobiology, UBC
2011 AACC, Rocky Mountain Section [Travel & Meeting] Scholarship
2004-2006 National Sciences and Engineering Council of Canada (NSERC) Postgraduate Scholarship – Master’s PGSM
2017 Mass Spectrometery in the Clinical Laboratory (MASCL) Meeting Travel Grant
2010 CIHR-INMHA Brain Star Award, September competition
2008 British Columbia Proteomics Network training allowance
2006-2008 National Sciences and Engineering Council of Canada (NSERC), Canada Graduate Scholarship – Doctoral CGSD
2006-2008 Michael Smith Foundation for Health Research (MSFHR) Junior Trainee Award
2011 University of Utah, Department of Pathology Research Support Funds
2007 Michael W. Stahl Memorial Graduate Scholarship – University of British Columbia
2006 Young Scientist [Travel] Award – 13th Biennial Winter Workshop on Schizophrenia Research
2008-2010 Michael Smith Foundation for Health Research (MSFHR) Senior Trainee Award
2012 American Association for Clinical Chemistry (AACC), Society for Young Clinical Laboratorians (SYCL) 2012 Domestic Travel GrantResearch Group Members
Ria Garg, Doctoral Student
Iryna Kayda, Volunteer
Veena Lin, Medical Student:
Teila McLaren-Gabriel, Medical Student: