Overview

Recent evidence suggests that a mother's diet during pregnancy can influence the development of cardiovascular disease (CVD) risk factors in their adult children. Currently my research focuses on determining how this occurs. I speculate that maternal diet during pregnancy can influence gene expression in children through epigenetic processes, defined as heritable changes in gene expression that occur without a change in the DNA sequence of the gene. I’m conducting studies in mice to determine the roles of prenatal and early postnatal diet and the role of epigenetic processes in the development of CVD, and am addressing the questions: if diet during adult life can change epigenetic processes, what happens to offspring exposed early in development to a similar nutrient insult, and are there consequences later in life? Overall determining how diet and epigenetic processes contribute to CVD will aid in the development of early screening tools for at-risk children, and novel therapeutic targets for prevention and treatment of CVD.

Publications

Diet and cardiometabolic side effects in children treated with second-generation antipsychotics
Clinical Nutrition ESPEN
Mikaela K. Barker, Carly M. Sable, Sarah E. Montgomery, Lorrie Chow, Timothy J. Green, Constadina Panagiotopoulos, Angela M. Devlin
DOI: 10.1016/j.clnesp.2017.09.013
10/2017

Serum Soluble Transferrin Receptor Concentrations Are Elevated in Congolese Children with Glucose-6-Phosphate Dehydrogenase Variants, but Not Sickle Cell Variants or a-Thalassemia.
The Journal of nutrition
DOI: 10.3945/jn.117.252635
PubMed: 28768839
09/2017

Developmental Outcomes at 24 Months of Age in Toddlers Supplemented with Arachidonic Acid and Docosahexaenoic Acid: Results of a Double Blind Randomized, Controlled Trial.
Nutrients
DOI: 10.3390/nu9090975
PubMed: 28878181
09/2017

The effect of oral iron with or without multiple micronutrients on hemoglobin concentration and hemoglobin response among nonpregnant Cambodian women of reproductive age: a 2 x 2 factorial, double-blind, randomized controlled supplementation trial.
The American journal of clinical nutrition
DOI: 10.3945/ajcn.116.140996
PubMed: 28490515
07/2017

The Val66Met brain-derived neurotrophic factor gene variant interacts with early pain exposure to predict cortisol dysregulation in 7-year-old children born very preterm: Implications for cognition.
Neuroscience
DOI: 10.1016/j.neuroscience.2015.08.044
PubMed: 26318333
02/2017

Sculpting infant soothability: the role of prenatal SSRI antidepressant exposure and neonatal SLC6A4 methylation status.
Developmental psychobiology
DOI: 10.1002/dev.21414
PubMed: 27254389
09/2016

Prevalence and Predictors of Low Vitamin B6 Status in Healthy Young Adult Women in Metro Vancouver
Nutrients
Chia-ling Ho, Teo Quay, Angela Devlin, Yvonne Lamers
DOI: 10.3390/nu8090538
09/2016

Folic Acid Supplementation of Female Mice, with or without Vitamin B-12, before and during Pregnancy and Lactation Programs Adiposity and Vascular Health in Adult Male Offspring.
The Journal of nutrition
PubMed: 26962174
03/2016

High prevalence of suboptimal vitamin B12 status in young adult women of South Asian and European ethnicity.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
DOI: 10.1139/apnm-2015-0200
PubMed: 26579949
12/2015

Prenatal alcohol exposure alters methyl metabolism and programs serotonin transporter and glucocorticoid receptor expression in brain.
American journal of physiology. Regulatory, integrative and comparative physiology
DOI: 10.1152/ajpregu.00075.2015
PubMed: 26180184
09/2015

Metabolic side effects and pharmacogenetics of second-generation antipsychotics in children
Pharmacogenomics
Angela M Devlin, Constadina Panagiotopoulos
DOI: 10.2217/pgs.15.55
06/2015

Obesity and arterial stiffness in children: systematic review and meta-analysis.
Arteriosclerosis, thrombosis, and vascular biology
DOI: 10.1161/atvbaha.114.305062
PubMed: 25633314
04/2015

Interaction between the Val158Met catechol-O-methyltransferase gene variant and second-generation antipsychotic treatment on blood pressure in children.
The pharmacogenomics journal
DOI: 10.1038/tpj.2014.35
PubMed: 25048416
02/2015

Genetic hemoglobin disorders rather than iron deficiency are a major predictor of hemoglobin concentration in women of reproductive age in rural prey Veng, Cambodia.
The Journal of nutrition
DOI: 10.3945/jn.114.198945
PubMed: 25527668
01/2015

Childhood obesity, arterial stiffness, and prevalence and treatment of hypertension.
Current treatment options in cardiovascular medicine
DOI: 10.1007/s11936-014-0339-9
PubMed: 25248796
11/2014

Initial screening of children treated with second-generation antipsychotics points to an association between physical activity and insulin resistance.
Pediatric exercise science
DOI: 10.1123/pes.2014-0076
PubMed: 25372380
11/2014

Quetiapine treatment in youth is associated with decreased insulin secretion.
Journal of clinical psychopharmacology
DOI: 10.1097/jcp.0000000000000118
PubMed: 24633003
06/2014

Chronic intermittent hypoxia causes endothelial dysfunction in a mouse model of diet-induced obesity.
Sleep medicine
DOI: 10.1016/j.sleep.2014.01.013
PubMed: 24767726
05/2014

Neonatal pain and COMT Val158Met genotype in relation to serotonin transporter (SLC6A4) promoter methylation in very preterm children at school age.
Frontiers in Behavioral Neuroscience
DOI: 10.3389/fnbeh.2014.00409
PubMed: 25520635
2014

Left ventricular mechanics and arterial-ventricular coupling following high-intensity interval exercise.
Journal of applied physiology (Bethesda, Md. : 1985)
DOI: 10.1152/japplphysiol.00576.2013
PubMed: 24052036
12/2013

Total and high molecular weight adiponectin and ethnic-specific differences in adiposity and insulin resistance: a cross-sectional study.
Cardiovascular diabetology
DOI: 10.1186/1475-2840-12-170
PubMed: 24225161
11/2013

Programming of Glucose Homeostasis by Developmental Exposure to Folic Acid and Vitamin B12 Imbalance in Female Mice
Canadian Journal of Diabetes
Jesse D. Olson, Rika E. Aleiunas, Melissa B. Glier, Abeer M. Aljaadi, Tim J. Green, Angela M. Devlin
DOI: 10.1016/j.jcjd.2013.08.213
10/2013

Dysfunctional Cardiac Lipid Metabolism in Cystathionine-Beta-Synthase Deficient Mice With Diet-Induced Weight Gain
Canadian Journal of Cardiology
MB Glier, JD Olson, SL Gerrard, RE Aleliunas, DC Sulistyoningrum, TJ Green, AM Devlin, AM Devlin
DOI: 10.1016/j.cjca.2013.07.264
10/2013

Childhood obesity and cardiovascular dysfunction.
Journal of the American College of Cardiology
DOI: 10.1016/j.jacc.2013.07.042
PubMed: 23954339
10/2013

Antidepressant use during pregnancy and serotonin transporter genotype (SLC6A4) affect newborn serum reelin levels.
Developmental psychobiology
DOI: 10.1002/dev.21056
PubMed: 22692766
07/2013

Methyl nutrients, DNA methylation, and cardiovascular disease
Molecular Nutrition & Food Research
Melissa B. Glier, Timothy J. Green, Angela M. Devlin
DOI: 10.1002/mnfr.201200636
05/2013

Programming of Adiposity by Gestational Exposure to Folic Acid and Vitamin B12 Imbalance
Canadian Journal of Diabetes
Rika E. Aleliunas, Jesse D. Olson, Abeer Aljaad, Melissa Glier, Ismail Laher, Tim Green, Angela Devlin
DOI: 10.1016/j.jcjd.2013.03.352
04/2013

Dysfunctional Cardiac Lipid Metabolism in Cystathionine-Beta-Synthase Deficient Mice with Obesity-related Cardiac Lipotoxicity
Canadian Journal of Diabetes
Melissa Glier, Jesse D. Olsen, Rika E. Aleliunas, Diane C. Sulistyoningrum, Sanjoy Ghosh, Tim J. Green, Angela M. Devlin
DOI: 10.1016/j.jcjd.2013.03.081
04/2013

The Fat Mass and Obesity Associated (FTO) rs9939609 Variant and Cardiometabolic Side-effects in Children Treated With Second-Generation Antipsychotics
Canadian Journal of Diabetes
Anita Cote, Ying F. Ngai, Constadina Panagiotopoulos, Angela M. Devlin
DOI: 10.1016/j.jcjd.2013.03.147
04/2013

Visceral Adiposity and The Relationship Between Vitamin D and Adiponectin
Canadian Journal of Diabetes
Dian Sulistyoningrum, Danijela Gasevic, Scott Lear, Angela Devlin
DOI: 10.1016/j.jcjd.2013.03.226
04/2013

Tissue-specific relationship of S-adenosylhomocysteine with allele-specific H19/Igf2 methylation and imprinting in mice with hyperhomocysteinemia.
Epigenetics
DOI: 10.4161/epi.23063
PubMed: 23221482
01/2013

Short-term exercise worsens cardiac oxidative stress and fibrosis in 8-month-old db/db mice by depleting cardiac glutathione.
Free radical research
DOI: 10.3109/10715762.2012.737463
PubMed: 23039789
01/2013

Short term exercise induces PGC-1a, ameliorates inflammation and increases mitochondrial membrane proteins but fails to increase respiratory enzymes in aging diabetic hearts.
PloS one
DOI: 10.1371/journal.pone.0070248
PubMed: 23936397
2013

Adiposity and the relationship between vitamin D and blood pressure
Metabolism
Dian C. Sulistyoningrum, Danijela Gasevic, Timothy J. Green, Scott A. Lear, Angela M. Devlin
DOI: 10.1016/j.metabol.2013.07.009
2013

Ethnic-Specific Differences in Vitamin D Status Is Associated with Adiposity
PLoS ONE
Dian C. Sulistyoningrum, Timothy J. Green, Scott A. Lear, Angela M. Devlin
DOI: 10.1371/journal.pone.0043159
08/2012

Epigenetic regulation of glucocorticoid receptor expression in aorta from mice with hyperhomocysteinemia
Epigenetics
Dian C. Sulistyoningrum, Ranji Singh, Angela M. Devlin
DOI: 10.4161/epi.19836
05/2012

Cardiometabolic risk and the MTHFR C677T variant in children treated with second-generation antipsychotics.
Translational psychiatry
DOI: 10.1038/tp.2011.68
PubMed: 22832733
2012

Associations of the FTO rs9939609 variant with discrete body fat depots and dietary intake in a multi-ethnic cohort.
Genetics research
DOI: 10.1017/s001667231100036x
PubMed: 22189607
12/2011

Altered glutathione homeostasis in heart augments cardiac lipotoxicity associated with diet-induced obesity in mice.
The Journal of biological chemistry
DOI: 10.1074/jbc.m111.304592
PubMed: 22021075
12/2011

Prenatal Exposure to Maternal Depressed Mood and the MTHFR C677T Variant Affect SLC6A4 Methylation in Infants at Birth
PLoS ONE
Angela M. Devlin, Ursula Brain, Jehannine Austin, Tim F. Oberlander
DOI: 10.1371/journal.pone.0012201
08/2010

Homocysteine-lowering vitamins do not lower plasma S-adenosylhomocysteine in older people with elevated homocysteine concentrations.
The British journal of nutrition
DOI: 10.1017/s0007114509993552
PubMed: 20089204
06/2010

Hepatic acyl-coenzyme a:cholesterol acyltransferase-2 expression is decreased in mice with hyperhomocysteinemia.
The Journal of nutrition
DOI: 10.3945/jn.109.112920
PubMed: 20018805
02/2010

Mechanisms of altered fatty acid and phospholipid levels in hyperhomocysteinemia
Clinical Lipidology
Angela M Devlin, Tim J Green
DOI: 10.2217/clp.09.3
04/2009

Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses.
Epigenetics
DOI: 10.4161/epi.3.2.6034
PubMed: 18536531
2008

Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia.
The Journal of biological chemistry
DOI: 10.1074/jbc.m704256200
PubMed: 17971455
12/2007

Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine concentrations in a healthy elderly population.
The American journal of clinical nutrition
PubMed: 16522921
03/2006

ApoA-I: a missing link between homocysteine and lipid metabolism?
Circulation research
DOI: 10.1161/01.res.0000214406.87060.e0
PubMed: 16514070
03/2006

Cerebral vascular dysfunction in methionine synthase-deficient mice.
Circulation
DOI: 10.1161/circulationaha.104.529248
PubMed: 16043641
08/2005

Tissue-specific Changes inH19Methylation and Expression in Mice with Hyperhomocysteinemia
Journal of Biological Chemistry
Angela M. Devlin, Teodoro Bottiglieri, Frederick E. Domann, Steven R. Lentz
DOI: 10.1074/jbc.m504815200
05/2005

Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice.
Blood
DOI: 10.1182/blood-2003-09-3078
PubMed: 14630804
04/2004

Glutamate carboxipeptidase II (GCPII) His475Tyr polymorphism and association studies
American Journal of Medical Genetics
Alexandre R. Vieira, Angela M. Devlin
DOI: 10.1002/ajmg.a.30241
2004

Evaluation of genetic variants in the reduced folate carrier and in glutamate carboxypeptidase II for spina bifida risk
Molecular Genetics and Metabolism
Isabelle Morin, Angela M Devlin, Daniel Leclerc, Nelly Sabbaghian, Charles H Halsted, Richard Finnell, Rima Rozen
DOI: 10.1016/s1096-7192(03)00086-6
07/2003

Metabolic interactions of alcohol and folate.
The Journal of nutrition
PubMed: 12163694
08/2002

Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig.
Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.112336399
PubMed: 12122204
07/2002

Folate deficiency, methionine metabolism, and alcoholic liver disease
Alcohol
Charles H Halsted, Jesus A Villanueva, Angela M Devlin
DOI: 10.1016/s0741-8329(02)00225-2
07/2002

Interactions of ethanol and folate deficiency in development of alcoholic liver disease in the micropig.
Transactions of the American Clinical and Climatological Association
PubMed: 12053707
2002

Reduced folate carrier: tissue distribution and effects of chronic ethanol intake in the micropig.
Alcoholism, clinical and experimental research
DOI: 10.1111/j.1530-0277.2001.tb02229.x
PubMed: 11290853
03/2001

Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia.
Human molecular genetics
DOI: 10.1093/hmg/9.19.2837
PubMed: 11092759
11/2000

Dietary phospholipid alters biliary lipid composition in formula-fed piglets
Lipids
Angela M. Devlin, Sheila M. Innis
DOI: 10.1007/s11745-999-0483-4
1999

Early Diet Influences Hepatic Lipogenesis
Lipids in Infant Nutrition
Sheila Innis, Angela Devlin
DOI: 10.1201/9781439831953.ch17
05/1998

Early diet influences hepatic hydroxymethyl glutaryl coenzyme A reductase and 7alpha-hydroxylase mRNA but not low-density lipoprotein receptor mRNA during development.
Metabolism: clinical and experimental
DOI: 10.1016/s0026-0495(98)90187-1
PubMed: 9440472
01/1998

Effect of medium-chain triglycerides on calbindin-D9k expression in the intestine
Lipids
Angela Devlin, Sheila M. Innis, Katharine Wall, John Krisinger
DOI: 10.1007/bf02522650
05/1996

Research

Maternal Diet & Epigenetic Regulation of Gene Expression
The goal of this project is to determine the effect of in utero exposure to changes in maternal homocysteine levels on epigenetic regulation of vascular gene expression in mice. These studies are funded by the Hospital for Sick Children Foundation.

DNA Methylation & Vascular Gene Expression
The goal of this project is to determine the effect of hyperhomocysteinemia, a cardiovascular disease risk factor, on loss of genomic imprinting of H19 , and to determine the role of H19 in the vascular pathology associated with hyperhomocysteinemia in mice. These studies are funded by the American Heart Association.

Grants

2016-2017 Healthy Starts Catalyst Grant "Determining the Long Term Metabolic Effects of Neonatal Sucrose Treatment"

NSERC Team Discovery Grant- Project: ``Biological effects of folate/cobalamin inbalance in mammals`` (2014-2019)

Honours & Awards

Establishment Award, BC Research Institute for Children's & Women's Health, 2004

McDonald Scholarship Award, 2006-2007

Research Group Members

Alejandra Wiedeman
Amanda Henderson, Endocrinology & Diabetes Unit
Nicha Boonpattrawong
Ei-Xia Mussai, Doctoral Student
Abeer Al'Jaadi
Nicholas Cruz, Research Volunteer
Melody Salehzadeh, Research Assistant
Cynthia Yamilka Ramírez Contreras
Iris Lee
Rebecca Lim