- Overview
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Recent evidence suggests that a mother's diet during pregnancy can influence the development of cardiovascular disease (CVD) risk factors in their adult children. Currently my research focuses on determining how this occurs. I speculate that maternal diet during pregnancy can influence gene expression in children through epigenetic processes, defined as heritable changes in gene expression that occur without a change in the DNA sequence of the gene. I’m conducting studies in mice to determine the roles of prenatal and early postnatal diet and the role of epigenetic processes in the development of CVD, and am addressing the questions: if diet during adult life can change epigenetic processes, what happens to offspring exposed early in development to a similar nutrient insult, and are there consequences later in life? Overall determining how diet and epigenetic processes contribute to CVD will aid in the development of early screening tools for at-risk children, and novel therapeutic targets for prevention and treatment of CVD.
- Publications
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Women in Canada are consuming above the upper intake level of folic acid but few are meeting dietary choline recommendations in the second trimester of pregnancy: data from the CHILD cohort study
Applied Physiology, Nutrition and Metabolism
DOI: 10.1139/apnm-2023-0258
2024Supplementation with (6S)-5-methyltetrahydrofolic acid appears as effective as folic acid in maintaining maternal folate status while reducing unmetabolised folic acid in maternal plasma: a randomised trial of pregnant women in Canada
British Journal of Nutrition
DOI: 10.1017/S0007114523001733
2024Vascular Complications in Children with Type 1 Diabetes: Protocol of a Scoping Review
OSF Registries
DOI: 10.17605/osf.io/kcxp2
2023Prenatal serotonin reuptake inhibitor antidepressant exposure, SLC6A4 genetic variations, and cortisol activity in 6-year-old children of depressed mothers: A cohort study
Developmental Psychobiology
DOI: 10.1002/dev.22425
2023Folic acid supplementation in a mouse model of diabetes in pregnancy alters insulin sensitivity in female mice and beta cell mass in offspring
FASEB Journal
DOI: 10.1096/fj.202301491R
2023Children Aged 5–6 Years in Vancouver, Canada Meet Dietary Recommendations for Folate and Vitamin B12 but not Choline
Journal of Nutrition
DOI: 10.1016/j.tjnut.2022.11.012
2023Riboflavin intake and status and relationship to anemia
Nutrition Reviews
DOI: 10.1093/nutrit/nuac043
2023Maternal nutrition and effects on offspring vascular function
Pflugers Archiv European Journal of Physiology
DOI: 10.1007/s00424-023-02807-x
2023Human milk unmetabolized folic acid is increased following supplementation with synthetic folic acid as compared to (6S)-5-methyltetrahydrofolic acid
Scientific Reports
DOI: 10.1038/s41598-023-38224-4
2023Global Vitamin D Intake and its Relation to Status in Children 1-10 Years of Age: A Scoping Review (Protocol)
OSF Registries
DOI: 10.17605/osf.io/a7vmb
2022The FTO rs9939609 Variant Is Associated with Cardiometabolic Disease Risk and Dietary Energy Intakes in Children with Mental Health Disorders
Current Developments in Nutrition
DOI: 10.1093/cdn/nzac014
2022Thermoneutral Housing and a Western Diet Combination Exacerbates Dysferlin-Deficient Muscular Dystrophy
Muscle and Nerve
Donen, G.S. and White, Z. and Sauge, E. and Ritso, M. and Theret, M. and Boyd, J. and Devlin, A.M. and Rossi, F.M.V. and Bernatchez, P.
DOI: 10.1002/mus.27680
2022Greater Arterial Stiffness in Children with or without Second-generation Antipsychotic Treatment for Mental Health Disorders: Rigidité Artérielle Plus Importante Chez Les Enfants Avec ou Sans Traitement Par Antipsychotiques de la Deuxième Génération Pour des Troubles de Santé Mentale
The Canadian Journal of Psychiatry
Amanda M. Henderson and Nazrul Islam and George G. S. Sandor and Constadina Panagiotopoulos and Angela M. Devlin
DOI: 10.1177/0706743720974838
07/2021Detectable Unmetabolized Folic Acid and Elevated Folate Concentrations in Folic Acid-Supplemented Canadian Children With Sickle Cell Disease.
Frontiers in nutrition
Williams BA and Mayer C and McCartney H and Devlin AM and Lamers Y and Vercauteren SM and Wu JK and Karakochuk CD
DOI: 10.3389/fnut.2021.642306
PubMed: 33968971
04/2021Dietary Riboflavin Intake and Riboflavin Status in Young Adult Women Living in Metro Vancouver, Canada
Current Developments in Nutrition
Abeer M Aljaadi and Alejandra M Wiedeman and Susan I Barr and Angela M Devlin and Tim J Green
DOI: 10.1093/cdn/nzab021
04/2021Sex-specific effects of neonatal oral sucrose treatment on growth and liver choline and glucocorticoid metabolism in adulthood
American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Ram{\'i}rez-Contreras, C.Y. and Mehran, A.E. and Salehzadeh, M. and Mussai, E.-X. and Miller, J.W. and Smith, A. and Ranger, M. and Holsti, L. and Soma, K.K. and Devlin, A.M.
DOI: 10.1152/ajpregu.00091.2021
2021Daily oral supplementation with 60 mg of elemental iron for 12 weeks alters blood mitochondrial dna content, but not leukocyte telomere length in cambodian women
Nutrients
Steele, S.L. and Hsieh, A.Y.Y. and Gadawski, I. and Kroeun, H. and Barr, S.I. and Devlin, A.M. and C{\^o}t{\'e}, H.C.F. and Karakochuk, C.D.
DOI: 10.3390/nu13061877
2021Treatment-related weight gain and metabolic complications in children with mental health disorders: Potential role for lifestyle interventions
Applied Physiology, Nutrition, and Metabolism
Alejandra M Wiedeman and Constadina Panagiotopoulos and Angela M. Devlin
DOI: 10.1139/apnm-2020-0259
11/2020Exercise during pregnancy mitigates the adverse effects of maternal obesity on adult male offspring vascular function and alters one-carbon metabolism
Physiological Reports
Nicha P. Boonpattrawong and Saeid Golbidi and Daven C. Tai and Rika E. Aleliunas and Pascal Bernatchez and Joshua W. Miller and Ismail Laher and Angela M. Devlin
DOI: 10.14814/phy2.14582
09/2020Assessing the Effectiveness of Targeted Social Media and Printed Posters as Tools to Recruit Pregnant Women to a Nutrition Trial in Vancouver, Canada.
Current developments in nutrition
Cochrane K and Karakochuk C and Mayer C and Devlin A and Elango R and Hutcheon J
05/2020Assessing the Effectiveness of Targeted Social Media and Printed Posters as Tools to Recruit Pregnant Women to a Nutrition Trial in Vancouver, Canada
Current Developments in Nutrition
Kelsey Cochrane and Crystal Karakochuk and Chantal Mayer and Angela Devlin and Rajavel Elango and Jennifer Hutcheon
DOI: 10.1093/cdn/nzaa056_012
05/2020Folic Acid Supplementation in Children with Sickle Cell Disease: Study Protocol for a Double-Blind Randomized Cross-Over Trial
Williams BA and McCartney H and Adams E and Devlin AM and Singer J and Vercauteren S and Wu JK and Karakochuk CD
DOI: 10.21203/rs.3.rs-30458/v1
05/2020Is natural (6S)-5-methyltetrahydrofolic acid as effective as synthetic folic acid in increasing serum and red blood cell folate concentrations during pregnancy? A proof-of-concept pilot study
Cochrane KM and Mayer C and Devlin AM and Elango R and Hutcheon JA and Karakochuk CD
DOI: 10.21203/rs.2.18214/v2
03/2020Ambulatory blood pressure and carotid intima media thickness in children with type 1 diabetes
Pediatric Diabetes
Sinead Glackin and Nazrul Islam and Amanda M. Henderson and Janis M. Dionne and Kevin C. Harris and Constadina Panagiotopoulos and Angela M. Devlin
DOI: 10.1111/pedi.12960
03/2020Biomarkers of Docosahexaenoic Acid but Not Arachidonic Acid Reflect Dietary Intakes in Toddlers at Ages 1 and 2 Years Who Are Not Meeting Dietary Recommendations
Journal of Nutrition
Wiedeman, A.M. and Dyer, R.A. and McCarthy, D. and Yurko-Mauro, K. and Innis, S.M. and Devlin, A.M.
DOI: 10.1093/jn/nxz280
2020Sheila M. Innis, PhD, RD (1953-2016): A Pioneer and Innovator Influencing the Maternal and Infant Nutrition Field
The Journal of nutrition
Field, C.J. and Devlin, A.M. and Atkinson, S.
DOI: 10.1093/jn/nxaa078
2020459-P: Risk for Type 2 Diabetes and Cardiovascular Health in Children Treated with Second-Generation Antipsychotics
Diabetes
AMANDA M. HENDERSON and NAZRUL ISLAM and GEORGE GABOR SANDOR and CONSTADINA PANAGIOTOPOULOS and ANGELA M. DEVLIN
DOI: 10.2337/db19-459-p
06/2019290-LB: Repeated Neonatal Oral Sucrose Treatment Affects Growth and Insulin-Like Growth Factor-1 in Mice
Diabetes
CYNTHIA YAMILKA RAMIREZ CONTRERAS and EI-XIA MUSSAI and ALEJANDRA M. WIEDEMAN and ARYA MEHRAN and MELODY SALEHZADEH and NICHA BOONPATTRAWONG and MANON RANGER and KIRAN K. SOMA and LIISA HOLSTI and ANGELA M. DEVLIN
DOI: 10.2337/db19-290-lb
06/20191395-P: Maternal Exercise during Pregnancy Affects Offspring Adiposity through One Carbon Metabolism Cycle
Diabetes
NICHA BOONPATTRAWONG and ARYA MEHRAN and ISMAIL LAHER and ANGELA M. DEVLIN
DOI: 10.2337/db19-1395-p
06/201970-LB: Fat Mass and Obesity-Associated rs9939609 Gene Variant Is Related to Fasting Glucose in Children with Mental Health Conditions
Diabetes
ALEJANDRA M. WIEDEMAN and YING FAI NGAI and AMANDA M. HENDERSON and CONSTADINA PANAGIOTOPOULOS and ANGELA M. DEVLIN
DOI: 10.2337/db19-70-lb
06/2019Impact of Prenatal Selective Serotonin Reuptake Inhibitor Antidepressant Exposure and Maternal Mood on Physical Activity, Dietary Intake, and Markers of Adiposity at Age 6 Years
Journal of Developmental & Behavioral Pediatrics
Sarah M. Hutchison and Louise C. Mâsse and Melissa B. Glier and Ursula Brain and Angela M. Devlin and Tim F. Oberlander
DOI: 10.1097/dbp.0000000000000658
03/2019Suboptimal Biochemical Riboflavin Status Is Associated with Lower Hemoglobin and Higher Rates of Anemia in a Sample of Canadian and Malaysian Women of Reproductive Age
Journal of Nutrition
Aljaadi, A.M. and How, R.E. and Loh, S.P. and Hunt, S.E. and Karakochuk, C.D. and Barr, S.I. and McAnena, L. and Ward, M. and McNulty, H. and Khor, G.L. and Devlin, A.M. and Green, T.J.
DOI: 10.1093/jn/nxz151
2019Adiposity and Carotid Intima Media Thickness in Children with Type 1 Diabetes
Atherosclerosis Supplements
Sinead Glackin and Nazrul Islam and Kevin Harris and Constadina Panagiotopolous and Angela Devlin
DOI: 10.1016/j.atherosclerosissup.2018.04.215
06/2018Abnormal Ambulatory Blood Pressure and Adiposity Predict Carotid Intima Media Thickness in Children with Type 1 Diabetes
Atherosclerosis Supplements
Sinead Glackin and Nazrul Islam and Janis Dionne and Constadina Panagiotopolous and Angela Devlin
DOI: 10.1016/j.atherosclerosissup.2018.04.066
06/2018Maternal Exercise Improves Glucose Homeostasis and Vascular Health in Male Offspring
Atherosclerosis Supplements
Nicha Boonpattrawong and Saeid Golbidi and Ismail Laher and Angela Devlin
DOI: 10.1016/j.atherosclerosissup.2018.04.048
06/2018Maternal folic acid supplementation with vitamin B 12 deficiency during pregnancy and lactation affects the metabolic health of adult female offspring but is dependent on offspring diet
The FASEB Journal
Amanda M. Henderson and Daven C. Tai and Rika E. Aleliunas and Abeer M. Aljaadi and Melissa B. Glier and Eric E. Xu and Joshua W. Miller and C. Bruce Verchere and Tim J. Green and Angela M. Devlin
DOI: 10.1096/fj.201701503rr
04/2018Comparison of a New Multiplex Immunoassay for Measurement of Ferritin, Soluble Transferrin Receptor, Retinol-Binding Protein, C-Reactive Protein and a1-Acid-glycoprotein Concentrations against a Widely-Used s-ELISA Method
Diagnostics
Crystal Karakochuk and Amanda Henderson and Kaitlyn Samson and Abeer Aljaadi and Angela Devlin and Elodie Becquey and James Wirth and Fabian Rohner
DOI: 10.3390/diagnostics8010013
02/2018CHIPS-Child: Testing the developmental programming hypothesis in the offspring of the CHIPS trial
Pregnancy Hypertension
Magee, L.A. and Synnes, A.R. and von Dadelszen, P. and Hutfield, A.M. and Chanoine, J.-P. and Côté, A.-M. and Devlin, A.M. and Dorling, J. and Gafni, A. and Ganzevoort, W. and Helewa, M.E. and Hutton, E.K. and Koren, G. and Lee, S.K. and Mcarthur, D. and Rey, E. and Robinson, W.P. and Roseboom, T.J. and Singer, J. and Wilson, S. and Moutquin, J.M.
DOI: 10.1016/j.preghy.2018.04.021
2018Risperidone But Not Quetiapine Treatment Is Associated With Increased Appetite But Not Satiety Hormones in Children During An Oral Glucose Tolerance Test
Journal of Clinical Psychopharmacology
Ying Fai Ngai and Angela M. Devlin and Constadina Panagiotopoulos
DOI: 10.1097/jcp.0000000000000956
2018L-5-methyltetrahydrofolate supplementation increases blood folate concentrations to a greater extent than folic acid supplementation in Malaysian women
Journal of Nutrition
Henderson, A.M. and Aleliunas, R.E. and Loh, S.P. and Khor, G.L. and Harvey-Leeson, S. and Glier, M.B. and Kitts, D.D. and Green, T.J. and Devlin, A.M.
DOI: 10.1093/jn/nxy057
2018Children's stress regulation mediates the association between prenatal maternal mood and child executive functions for boys, but not girls
Development and Psychopathology
Neuenschwander, R. and Hookenson, K. and Brain, U. and Grunau, R.E. and Devlin, A.M. and Weinberg, J. and Diamond, A. and Oberlander, T.F.
DOI: 10.1017/S095457941800041X
2018Diet and cardiometabolic side effects in children treated with second-generation antipsychotics
Clinical Nutrition ESPEN
Barker, M.K. and Sable, C.M. and Montgomery, S.E. and Chow, L. and Green, T.J. and Panagiotopoulos, C. and Devlin, A.M.
DOI: 10.1016/j.clnesp.2017.09.013
2018Plasma betaine is positively associated with developmental outcomes in healthy toddlers at age 2 years who are not meeting the recommended adequate intake for dietary choline
Journal of Nutrition
Wiedeman, A.M. and Chau, C.M.Y. and Grunau, R.E. and McCarthy, D. and Yurko-Mauro, K. and Dyer, R.A. and Innis, S.M. and Devlin, A.M.
DOI: 10.1093/jn/nxy108
2018Serum soluble transferrin receptor concentrations are elevated in Congolese children with glucose-6-phosphate dehydrogenase variants, but not sickle cell variants or a-thalassemia
Journal of Nutrition
Barker, M.K. and Henderson, A.M. and Naguib, K. and Vercauteren, S.M. and Devlin, A.M. and Albert, A.Y. and Bahizire, E. and Tugirimana, P.L. and Akilimali, P.Z. and Boy, E. and Green, T.J. and Karakochuk, C.D.
DOI: 10.3945/jn.117.252635
2017Developmental Outcomes at 24 Months of Age in Toddlers Supplemented with Arachidonic Acid and Docosahexaenoic Acid: Results of a Double Blind Randomized, Controlled Trial
Nutrients
Devlin, A.M. and Chau, C.M.Y. and Dyer, R. and Matheson, J. and McCarthy, D. and Yurko-Mauro, K. and Innis, S.M. and Grunau, R.E.
DOI: 10.3390/nu9090975
2017The effect of oral iron with or without multiple micronutrients on hemoglobin concentration and hemoglobin response among nonpregnant Cambodian women of reproductive age: A 2 × 2 factorial, double-blind, randomized controlled supplementation trial
American Journal of Clinical Nutrition
Karakochuk, C.D. and Barker, M.K. and Whitfield, K.C. and Barr, S.I. and Vercauteren, S.M. and Devlin, A.M. and Hutcheon, J.A. and Houghton, L.A. and Prak, S. and Hou, K. and Chai, T.L. and Stormer, A. and Ly, S. and Devenish, R. and Oberkanins, C. and Pühringer, H. and Harding, K.B. and De-Regil, L.M. and Kraemer, K. and Green, T.J.
DOI: 10.3945/ajcn.116.140996
2017The Val66Met brain-derived neurotrophic factor gene variant interacts with early pain exposure to predict cortisol dysregulation in 7-year-old children born very preterm: Implications for cognition
Neuroscience
Chau, C.M.Y. and Cepeda, I.L. and Devlin, A.M. and Weinberg, J. and Grunau, R.E.
DOI: 10.1016/j.neuroscience.2015.08.044
2017Folic Acid Supplementation of Female Mice, with or without Vitamin B-12, before and during Pregnancy and Lactation Programs Adiposity and Vascular Health in Adult Male Offspring.
The Journal of nutrition
PubMed: 26962174
03/2016Folic acid supplementation of female mice, with or without vitamin B-12, before and during pregnancy and lactation programs adiposity and vascular health in adult male offspring
Journal of Nutrition
Aleliunas, R.E. and Aljaadi, A.M. and Laher, I. and Glier, M.B. and Green, T.J. and Murphy, M. and Miller, J.W. and Devlin, A.M.
DOI: 10.3945/jn.115.227629
2016Sculpting infant soothability: the role of prenatal SSRI antidepressant exposure and neonatal SLC6A4 methylation status
Developmental Psychobiology
Gartstein, M.A. and Hookenson, K.V. and Brain, U. and Devlin, A.M. and Grunau, R.E. and Oberlander, T.F.
DOI: 10.1002/dev.21414
2016Prevalence and predictors of low vitamin B6 status in healthy young adult women in metro vancouver
Nutrients
Ho, C.-L. and Quay, T.A.W. and Devlin, A.M. and Lamers, Y.
DOI: 10.3390/nu8090538
2016High prevalence of suboptimal vitamin B
12 status in young adult women of South Asian and European ethnicity
Applied Physiology, Nutrition and Metabolism
Quay, T.A.W. and Schroder, T.H. and Jeruszka-Bielak, M. and Li, W. and Devlin, A.M. and Barr, S.I. and Lamers, Y.
DOI: 10.1139/apnm-2015-0200
2015Prenatal alcohol exposure alters methyl metabolism and programs serotonin transporter and glucocorticoid receptor expression in brain
American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Ngai, Y.F. and Sulistyoningrum, D.C. and O?Neill, R. and Innis, S.M. and Weinberg, J. and Devlin, A.M.
DOI: 10.1152/ajpregu.00075.2015
2015Obesity and arterial stiffness in children: Systematic review and meta-analysis
Arteriosclerosis, Thrombosis, and Vascular Biology
Cote, A.T. and Phillips, A.A. and Harris, K.C. and Sandor, G.G.S. and Panagiotopoulos, C. and Devlin, A.M.
DOI: 10.1161/ATVBAHA.114.305062
2015Genetic hemoglobin disorders rather than iron deficiency are a major predictor of hemoglobin concentration in women of reproductive age in rural prey veng, Cambodia
Journal of Nutrition
Karakochuk, C.D. and Whitfield, K.C. and Barr, S.I. and Lamers, Y. and Devlin, A.M. and Vercauteren, S.M. and Kroeun, H. and Talukder, A. and McLean, J. and Green, T.J.
DOI: 10.3945/jn.114.198945
2015Metabolic side effects and pharmacogenetics of second-generation antipsychotics in children
Pharmacogenomics
Devlin, A.M. and Panagiotopoulos, C.
DOI: 10.2217/pgs.15.55
2015Interaction between the Val158Met catechol-O-methyltransferase gene variant and second-generation antipsychotic treatment on blood pressure in children
Pharmacogenomics Journal
Cote, A.T. and Panagiotopoulos, C. and Devlin, A.M.
DOI: 10.1038/tpj.2014.35
2015Initial screening of children treated with second-generation antipsychotics points to an association between physical activity and insulin resistance
Pediatric Exercise Science
Cote, A.T. and Devlin, A.M. and Panagiotopoulos, C.
DOI: 10.1123/pes.2014-0076
2014Childhood Obesity, Arterial Stiffness, and Prevalence and Treatment of Hypertension
Current Treatment Options in Cardiovascular Medicine
Armstrong, K.R. and Cote, A.T. and Devlin, A.M. and Harris, K.C.
DOI: 10.1007/s11936-014-0339-9
2014Methyl nutrients, DNA methylation, and cardiovascular disease
Molecular Nutrition and Food Research
Glier, M.B. and Green, T.J. and Devlin, A.M.
DOI: 10.1002/mnfr.201200636
2014Neonatal pain and comt Val158Met genotype in relation to serotonin transporter (SLC6A4) promoter methylation in very preterm children at school age
Frontiers in Behavioral Neuroscience
Chau, C.M.Y. and Ranger, M. and Sulistyoningrum, D. and Devlin, A.M. and Obertander, T.F. and Grunau, R.E.
DOI: 10.3389/fnbeh.2014.00409
2014Quetiapine treatment in youth is associated with decreased insulin secretion
Journal of Clinical Psychopharmacology
Ngai, Y.F. and Sabatini, P. and Nguyen, D. and Davidson, J. and Chanoine, J.-P. and Devlin, A.M. and Lynn, F.C. and Panagiotopoulos, C.
DOI: 10.1097/JCP.0000000000000118
2014Chronic intermittent hypoxia causes endothelial dysfunction in a mouse model of diet-induced obesity
Sleep Medicine
Badran, M. and Golbidi, S. and Devlin, A. and Ayas, N. and Laher, I.
DOI: 10.1016/j.sleep.2014.01.013
2014Programming of Glucose Homeostasis by Developmental Exposure to Folic Acid and Vitamin B12 Imbalance in Female Mice
Canadian Journal of Diabetes
Jesse D. Olson and Rika E. Aleiunas and Melissa B. Glier and Abeer M. Aljaadi and Tim J. Green and Angela M. Devlin
DOI: 10.1016/j.jcjd.2013.08.213
10/2013Dysfunctional Cardiac Lipid Metabolism in Cystathionine-Beta-Synthase Deficient Mice With Diet-Induced Weight Gain
Canadian Journal of Cardiology
MB Glier and JD Olson and SL Gerrard and RE Aleliunas and DC Sulistyoningrum and TJ Green and AM Devlin and AM Devlin
DOI: 10.1016/j.cjca.2013.07.264
10/2013The Fat Mass and Obesity Associated (FTO) rs9939609 Variant and Cardiometabolic Side-effects in Children Treated With Second-Generation Antipsychotics
Canadian Journal of Diabetes
Anita Cote and Ying F. Ngai and Constadina Panagiotopoulos and Angela M. Devlin
DOI: 10.1016/j.jcjd.2013.03.147
04/2013Programming of Adiposity by Gestational Exposure to Folic Acid and Vitamin B12 Imbalance
Canadian Journal of Diabetes
Rika E. Aleliunas and Jesse D. Olson and Abeer Aljaad and Melissa Glier and Ismail Laher and Tim Green and Angela Devlin
DOI: 10.1016/j.jcjd.2013.03.352
04/2013Dysfunctional Cardiac Lipid Metabolism in Cystathionine-Beta-Synthase Deficient Mice with Obesity-related Cardiac Lipotoxicity
Canadian Journal of Diabetes
Melissa Glier and Jesse D. Olsen and Rika E. Aleliunas and Diane C. Sulistyoningrum and Sanjoy Ghosh and Tim J. Green and Angela M. Devlin
DOI: 10.1016/j.jcjd.2013.03.081
04/2013Visceral Adiposity and The Relationship Between Vitamin D and Adiponectin
Canadian Journal of Diabetes
Dian Sulistyoningrum and Danijela Gasevic and Scott Lear and Angela Devlin
DOI: 10.1016/j.jcjd.2013.03.226
04/2013Adiposity and the relationship between vitamin D and blood pressure
Metabolism: Clinical and Experimental
Sulistyoningrum, D.C. and Gasevic, D. and Green, T.J. and Lear, S.A. and Devlin, A.M.
DOI: 10.1016/j.metabol.2013.07.009
2013Left ventricular mechanics and arterial-ventricular coupling following high-intensity interval exercise
Journal of Applied Physiology
Cote, A.T. and Bredin, S.S.D. and Phillips, A.A. and Koehle, M.S. and Glier, M.B. and Devlin, A.M. and Warburton, D.E.R.
DOI: 10.1152/japplphysiol.00576.2013
2013Short Term Exercise Induces PGC-1a, Ameliorates Inflammation and Increases Mitochondrial Membrane Proteins but Fails to Increase Respiratory Enzymes in Aging Diabetic Hearts
PLoS ONE
Botta, A. and Laher, I. and Beam, J. and DeCoffe, D. and Brown, K. and Halder, S. and Devlin, A. and Gibson, D.L. and Ghosh, S.
DOI: 10.1371/journal.pone.0070248
2013Childhood obesity and cardiovascular dysfunction
Journal of the American College of Cardiology
Cote, A.T. and Harris, K.C. and Panagiotopoulos, C. and Sandor, G.G.S. and Devlin, A.M.
DOI: 10.1016/j.jacc.2013.07.042
2013Antidepressant use during pregnancy and serotonin transporter genotype (SLC6A4) Affect newborn serum reelin levels
Developmental Psychobiology
Brummelte, S. and Galea, L.A.M. and Devlin, A.M. and Oberlander, T.F.
DOI: 10.1002/dev.21056
2013Total and high molecular weight adiponectin and ethnic-specific differences in adiposity and insulin resistance: A cross-sectional study
Cardiovascular Diabetology
Sulistyoningrum, D.C. and Gasevic, D. and Lear, S.A. and Ho, J. and Mente, A. and Devlin, A.M.
DOI: 10.1186/1475-2840-12-170
2013Tissue-specific relationship of S-adenosylhomocysteine with allele-specific H19/Igf2 methylation and imprinting in mice with hyperhomocysteinemia
Epigenetics
Glier, M.B. and Ngai, Y.F. and Sulistyoningrum, D.C. and Aleliunas, R.E. and Bottiglieri, T. and Devlin, A.M.
DOI: 10.4161/epi.23063
2013Short-term exercise worsens cardiac oxidative stress and fibrosis in 8-month-old db/db mice by depleting cardiac glutathione
Free Radical Research
Laher, I. and Beam, J. and Botta, A. and Barendregt, R. and Sulistyoningrum, D. and Devlin, A. and Rheault, M. and Ghosh, S.
DOI: 10.3109/10715762.2012.737463
2013Ethnic-Specific Differences in Vitamin D Status Is Associated with Adiposity
PLoS ONE
Sulistyoningrum, D.C. and Green, T.J. and Lear, S.A. and Devlin, A.M.
DOI: 10.1371/journal.pone.0043159
2012Epigenetic regulation of glucocorticoid receptor expression in aorta from mice with hyperhomocysteinemia
Epigenetics
Sulistyoningrum, D.C. and Singh, R. and Devlin, A.M.
DOI: 10.4161/epi.19836
2012Cardiometabolic risk and the MTHFR C677T variant in children treated with second-generation antipsychotics
Translational Psychiatry
Devlin, A.M. and Ngai, Y.F. and Ronsley, R. and Panagiotopoulos, C.
DOI: 10.1038/tp.2011.68
2012Altered glutathione homeostasis in heart augments cardiac lipotoxicity associated with diet-induced obesity in mice
Journal of Biological Chemistry
Ghosh, S. and Sulistyoningrum, D.C. and Glier, M.B. and Verchere, C.B. and Devlin, A.M.
DOI: 10.1074/jbc.M111.304592
2011Associations of the FTO rs9939609 variant with discrete body fat depots and dietary intake in a multi-ethnic cohort
Genetics Research
Lear, S.A. and Deng, W.Q. and Par?, G. and Sulistyoningrum, D.C. and Loos, R.J.F. and Devlin, A.
DOI: 10.1017/S001667231100036X
2011Homocysteine-lowering vitamins do not lower plasma S-adenosylhomocysteine in older people with elevated homocysteine concentrations
British Journal of Nutrition
Green, T.J. and Skeaff, C.M. and McMahon, J.A. and Venn, B.J. and Williams, S.M. and Devlin, A.M. and Innis, S.M.
DOI: 10.1017/S0007114509993552
2010Hepatic acyl-coenzyme A:cholesterol acyltransferase-2 expression is decreased in mice with hyperhomocysteinemia
Journal of Nutrition
Devlin, A.M. and Singh, R. and Bottiglieri, T. and Innis, S.M. and Green, T.J.
DOI: 10.3945/jn.109.112920
2010Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birth
PLoS ONE
Devlin, A.M. and Brain, U. and Austin, J. and Oberlander, T.F.
DOI: 10.1371/journal.pone.0012201
2010Mechanisms of altered fatty acid and phospholipid levels in hyperhomocysteinemia
Future Lipidology
Devlin, A.M. and Green, T.J.
DOI: 10.2217/CLP.09.3
2009Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses
Epigenetics
Oberlander, T.F. and Weinberg, J. and Papsdorf, M. and Grunau, R. and Misri, S. and Devlin, A.M.
DOI: 10.4161/epi.3.2.6034
2008Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia
Journal of Biological Chemistry
Devlin, A.M. and Singh, R. and Wade, R.E. and Innis, S.M. and Bottiglieri, T. and Lentz, S.R.
DOI: 10.1074/jbc.M704256200
2007Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine concentrations in a healthy elderly population.
The American journal of clinical nutrition
PubMed: 16522921
03/2006Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine concentrations in a healthy elderly population
American Journal of Clinical Nutrition
Devlin, A.M. and Clarke, R. and Birks, J. and Evans, J.G. and Halsted, C.H.
DOI: 10.1093/ajcn.83.3.708
2006ApoA-I: A missing link between homocysteine and lipid metabolism?
Circulation Research
Devlin, A.M. and Lentz, S.R.
DOI: 10.1161/01.RES.0000214406.87060.e0
2006Cerebral vascular dysfunction in methionine synthase-deficient mice
Circulation
Dayal, S. and Devlin, A.M. and McCaw, R.B. and Liu, M.-L. and Arning, E. and Bottiglieri, T. and Shane, B. and Faraci, F.M. and Lentz, S.R.
DOI: 10.1161/CIRCULATIONAHA.104.529248
2005Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia
Journal of Biological Chemistry
Devlin, A.M. and Bottiglieri, T. and Domann, F.E. and Lentz, S.R.
DOI: 10.1074/jbc.M504815200
2005Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice
Blood
Devlin, A.M. and Arning, E. and Bottiglieri, T. and Faraci, F.M. and Rozen, R. and Lentz, S.R.
DOI: 10.1182/blood-2003-09-3078
2004Glutamate carboxipeptidase II (GCPII) His475Tyr polymorphism and association studies [5]
American Journal of Medical Genetics
Vieira, A.R. and Devlin, A.M.
DOI: 10.1002/ajmg.a.30241
2004Evaluation of genetic variants in the reduced folate carrier and in glutamate carboxypeptidase II for spina bifida risk
Molecular Genetics and Metabolism
Morin, I. and Devlin, A.M. and Leclerc, D. and Sabbaghian, N. and Halsted, C.H. and Finnell, R. and Rozen, R.
DOI: 10.1016/S1096-7192(03)00086-6
2003Metabolic interactions of alcohol and folate.
The Journal of nutrition
PubMed: 12163694
08/2002Folate deficiency, methionine metabolism, and alcoholic liver disease
Alcohol
DOI: 10.1016/S0741-8329(02)00225-2
2002Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig
Proceedings of the National Academy of Sciences of the United States of America
Halsted, C.H. and Villanueva, J.A. and Devlin, A.M. and Niemelä, O. and Parkkila, S. and Garrow, T.A. and Wallock, L.M. and Shigenaga, M.K. and Melnyk, S. and James, S.J.
DOI: 10.1073/pnas.112336399
2002Metabolic interactions of alcohol and folate
Journal of Nutrition
DOI: 10.1093/jn/132.8.2367s
2002Interactions of ethanol and folate deficiency in development of alcoholic liver disease in the micropig.
Transactions of the American Clinical and Climatological Association
Halsted, C.H. and Villanueva, J.A. and Devlin, A.M. and James, S.J.
2002Reduced folate carrier: Tissue distribution and effects of chronic ethanol intake in the micropig
Alcoholism: Clinical and Experimental Research
Villanueva, J.A. and Devlin, A.M. and Halsted, C.H.
DOI: 10.1111/j.1530-0277.2001.tb02229.x
2001Glutamate carboxypeptidase II: A polymorphism associated with lower levels of serum folate and hyperhomocysteinemia
Human Molecular Genetics
Devlin, A.M. and Ling, E.-H. and Peerson, J.M. and Fernando, S. and Clarke, R. and Smith, A.D. and Halsted, C.H.
DOI: 10.1093/hmg/9.19.2837
2000Dietary phospholipid alters biliary lipid composition in formula-fed piglets
Lipids
Devlin, A.M. and Innis, S.M.
DOI: 10.1007/s11745-999-0483-4
1999Early Diet Influences Hepatic Lipogenesis
Lipids in Infant Nutrition
Sheila Innis and Angela Devlin
DOI: 10.1201/9781439831953.ch17
05/1998Dietary long chain polyunsaturated fatty acids alter hepatic sterol metabolism in newborn piglets
FASEB Journal
Devlin, A.M. and Innis, S.M.
1998Early diet influences hepatic hydroxymethyl glutaryl coenzyme a reductase and 7a-hydroxylase mRNA but not low-density lipoprotein receptor mRNA during development
Metabolism: Clinical and Experimental
Devlin, A.M. and Innis, S.M. and Shukin, R. and Rioux, M.F.
DOI: 10.1016/S0026-0495(98)90187-1
1998Influence of early diet on hepatic lipid metabolism
FASEB Journal
Devlin, A.M. and Innis, S.M.
1997Alterations in hepatic cholesterol metabolism during development
FASEB Journal
Devlin, A. and Rioux, F. and Innis, S.M.
1996Effect of medium-chain triglycerides on calbindin-D9k expression in the intestine
Lipids
Devlin, A. and Innis, S.M. and Wall, K. and Krisinger, J.
DOI: 10.1007/BF02522650
1996 - Research
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Maternal Diet & Epigenetic Regulation of Gene Expression
The goal of this project is to determine the effect of in utero exposure to changes in maternal homocysteine levels on epigenetic regulation of vascular gene expression in mice. These studies are funded by the Hospital for Sick Children Foundation.DNA Methylation & Vascular Gene Expression
The goal of this project is to determine the effect of hyperhomocysteinemia, a cardiovascular disease risk factor, on loss of genomic imprinting of H19 , and to determine the role of H19 in the vascular pathology associated with hyperhomocysteinemia in mice. These studies are funded by the American Heart Association.Grants"Biological effects of folate/cobalamin imbalance in mammals" (2014-2019)
NSERC Team Discovery Grant- Project
2016-2017 Healthy Starts Catalyst Grant "Determining the Long Term Metabolic Effects of Neonatal Sucrose Treatment"
Honours & AwardsEstablishment Award, BC Research Institute for Children's & Women's Health, 2004
McDonald Scholarship Award, 2006-2007
Research Group MembersCoralie Bergeron, Master Student
Makenna Clement-Ranney, NSERC USRA Student
Olyvia Guo, Volunteer
Elaine Huang, NSERC Undergraduate Research Assistant
Adam Hung, Doctoral Student
Mayu Kajino, Visiting researcher
Ladan Kalani, Research Technician
Rida Khan
Zoe Lofft, PhD Student
Alejandra Wiedeman, Research Associate
Christopher Yuen, PhD Student
Type 1 diabetes pressures the heart from the start
According to a new study, children with Type 1 diabetes have six-fold greater odds of abnormal blood pressure than children without the disease, even from the very beginning.
