Chronic kidney disease (CKD) is a significant and growing public health problem. It is currently estimated that 13% of the adult population has CKD and it confers a 5-fold increased risk of premature cardiovascular disease and death. Those who survive long enough eventually require renal replacement therapy with dialysis or a kidney transplant. Many of the risk factors for CKD begin in childhood. a patient develops CKD, the pathological changes that worsen dysfunction are similar in all kidney diseases, and are characterized by a process of ongoing scarring or fibrosis. Despite tremendous progress in our understanding of the causes and consequences of CKD, effective therapies are unknown. Using experimental models of CKD, our studies are designed to investigate how specific cells and molecules mediate kidney fibrosis, with the ultimate goal of translating our findings into new human therapies.
Standardised Outcomes in Nephrology-Children and Adolescents (SONG-Kids): a protocol for establishing a core outcome set for children with chronic kidney disease.
Tong A, Samuel S, Zappitelli M, Dart A, Furth S, Eddy A, Groothoff J, Webb NJ, Yap HK, Bockenhauer D, Sinha A, Alexander SI, Goldstein SL, Gipson DS, Hanson CS, Evangelidis N, Crowe S, Harris T, Hemmelgarn BR, Manns B
Cysteamine modulates oxidative stress and blocks myofibroblast activity in CKD.
Okamura DM, Bahrami NM, Ren S, Pasichnyk K, Williams JM, Gangoiti JA, Lopez-Guisa JM, Yamaguchi I, Barshop BA, Duffield JS, Eddy AA
The Canadian Childhood Nephrotic Syndrome (CHILDNEPH) Project: overview of design and methods.
Samuel S, Scott S, Morgan C, Dart A, Mammen C, Parekh R, Nettel-Aguirre A, Eddy A, Flynn R, Pinsk M, Wade A, Arora S, Benoit G, Bitzan M, Erickson R, Feber J, Filler G, Geier P, Girardin C, Grisaru S
Acute kidney injury and its association with in-hospital mortality among children with acute infections.
Imani PD, Odiit A, Hingorani SR, Weiss NS, Eddy AA
Social paediatrics: From 'lip service' to the health and well-being of Canada's children and youth.
Daneman D, Kellner J, Bernstein M, Dow K, Dugas MA, Duffy C, Eddy A, Filler G, Frappier JY, Gilmour S, Givelichian L, Huang L, Rockman-Greenberg C, Shevell M, Vardy C, Walti H, Orrbine E, Williams M
Albumin-induced apoptosis of glomerular parietal epithelial cells is modulated by extracellular signal-regulated kinase 1/2.
Chang AM, Ohse T, Krofft RD, Wu JS, Eddy AA, Pippin JW, Shankland SJ
Mannose receptor 2 attenuates renal fibrosis.
López-Guisa JM, Cai X, Collins SJ, Yamaguchi I, Okamura DM, Bugge TH, Isacke CM, Emson CL, Turner SM, Shankland SJ, Eddy AA
Galectin-3 preserves renal tubules and modulates extracellular matrix remodeling in progressive fibrosis.
Okamura DM, Pasichnyk K, Lopez-Guisa JM, Collins S, Hsu DK, Liu FT, Eddy AA
Nicotinic acetylcholine receptor a1 promotes calpain-1 activation and macrophage inflammation in hypercholesterolemic nephropathy.
Zhang G, Thomas AL, Marshall AL, Kernan KA, Su Y, Zheng Y, Takano J, Saido TC, Eddy AA
A novel signaling pathway: fibroblast nicotinic receptor alpha1 binds urokinase and promotes renal fibrosis.
Zhang G, Kernan KA, Thomas A, Collins S, Song Y, Li L, Zhu W, Leboeuf RC, Eddy AA
Serine proteases, inhibitors and receptors in renal fibrosis.
CD36 regulates oxidative stress and inflammation in hypercholesterolemic CKD.
Okamura DM, Pennathur S, Pasichnyk K, López-Guisa JM, Collins S, Febbraio M, Heinecke J, Eddy AA
Phase I trial of rosiglitazone in FSGS: I. Report of the FONT Study Group.
Joy MS, Gipson DS, Dike M, Powell L, Thompson A, Vento S, Eddy A, Fogo AB, Kopp JB, Cattran D, Trachtman H
Angiotensin converting enzyme inhibitor but not angiotensin receptor blockade or statin ameliorates murine adriamycin nephropathy.
Tang SC, Leung JC, Chan LY, Eddy AA, Lai KN
Atherogenic scavenger receptor modulation in the tubulointerstitium in response to chronic renal injury.
Okamura DM, López-Guisa JM, Koelsch K, Collins S, Eddy AA
Endogenous urokinase lacks antifibrotic activity during progressive renal injury.
Yamaguchi I, Lopez-Guisa JM, Cai X, Collins SJ, Okamura DM, Eddy AA
Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: role of plasmin-activated signals.
Zhang G, Kernan KA, Collins SJ, Cai X, López-Guisa JM, Degen JL, Shvil Y, Eddy AA
Plasminogen activator inhibitor-1 deficiency has renal benefits but some adverse systemic consequences in diabetic mice.
Collins SJ, Alexander SL, Lopez-Guisa JM, Cai X, Maruvada R, Chua SC, Zhang G, Okamura DM, Matsuo S, Eddy AA
Multifunctionality of PAI-1 in fibrogenesis: evidence from obstructive nephropathy in PAI-1-overexpressing mice.
Matsuo S, López-Guisa JM, Cai X, Okamura DM, Alpers CE, Bumgarner RE, Peters MA, Zhang G, Eddy AA
Why is proteinuria an ominous biomarker of progressive kidney disease?
Zandi-Nejad K, Eddy AA, Glassock RJ, Brenner BM
Mitogenic signaling of urokinase receptor-deficient kidney fibroblasts: actions of an alternative urokinase receptor and LDL receptor-related protein.
Zhang G, Cai X, López-Guisa JM, Collins SJ, Eddy AA
The NPHP1 gene deletion associated with juvenile nephronophthisis is present in a subset of individuals with Joubert syndrome.
Parisi MA, Bennett CL, Eckert ML, Dobyns WB, Gleeson JG, Shaw DW, McDonald R, Eddy A, Chance PF, Glass IA
Urokinase receptor deficiency accelerates renal fibrosis in obstructive nephropathy.
Zhang G, Kim H, Cai X, López-Guisa JM, Alpers CE, Liu Y, Carmeliet P, Eddy AA
Urokinase receptor modulates cellular and angiogenic responses in obstructive nephropathy.
Zhang G, Kim H, Cai X, Lopez-Guisa JM, Carmeliet P, Eddy AA
Longterm followup of childhood lupus nephritis.
Hagelberg S, Lee Y, Bargman J, Mah G, Schneider R, Laskin C, Eddy A, Gladman D, Urowitz M, Hebert D, Silverman E
Plasminogen activator inhibitor-1 and the kidney.
PAI-1 deficiency attenuates the fibrogenic response to ureteral obstruction.
Oda T, Jung YO, Kim HS, Cai X, López-Guisa JM, Ikeda Y, Eddy AA
TIMP-1 deficiency does not attenuate interstitial fibrosis in obstructive nephropathy.
Kim H, Oda T, López-Guisa J, Wing D, Edwards DR, Soloway PD, Eddy AA
Role of cellular infiltrates in response to proteinuria.
Interstitial fibrosis in mice with overload proteinuria: deficiency of TIMP-1 is not protective.
Eddy AA, Kim H, López-Guisa J, Oda T, Soloway PD
Tubulointerstitial nephritis and uveitis in children and adolescents. Four new cases and a review of the literature.
Vohra S, Eddy A, Levin AV, Taylor G, Laxer RM
The nephrotic syndrome: from the simple to the complex.
Eddy AA, Schnaper HW
Failure of antioxidant therapy to attenuate interstitial disease in rats with reversible nephrotic syndrome.
Drukker A, Eddy AA
Molecular insights into renal interstitial fibrosis.
Expression of genes that promote renal interstitial fibrosis in rats with proteinuria.
Antiribosomal P antibodies in pediatric patients with systemic lupus erythematosus and psychosis.
Press J, Palayew K, Laxer RM, Elkon K, Eddy A, Rakoff D, Silverman ED
An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes.
Zhang L, Eddy A, Teng YT, Fritzler M, Kluppel M, Melet F, Bernstein A
Experimental insights into the tubulointerstitial disease accompanying primary glomerular lesions.
Protein restriction reduces transforming growth factor-beta and interstitial fibrosis in nephrotic syndrome.
Xanthogranulomatous pyelonephritis in children. Etiology, pathogenesis, clinical and radiologic features, and management.
Levy M, Baumal R, Eddy AA
Renal extracellular matrix accumulation in acute puromycin aminonucleoside nephrosis in rats.
Jones CL, Buch S, Post M, McCulloch L, Liu E, Eddy AA
The contribution of antibody-mediated cytotoxicity and immune-complex formation to tubulointerstitial disease in passive Heymann nephritis.
Eddy AA, Ho GC, Thorner PS
Pulmonary hemorrhage and necrotizing glomerulonephritis without glomerular immune deposits: report of two cases.
Jones CL, Shields M, Eddy AA, Baumal R, O'Neill M, Geary DF
A relationship between proteinuria and acute tubulointerstitial disease in rats with experimental nephrotic syndrome.
Eddy AA, McCulloch L, Liu E, Adams J
Tubulointerstitial nephritis during the heterologous phase of nephrotoxic serum nephritis.
A study by immunofluorescence microscopy of the NC1 domain of collagen type IV in glomerular basement membranes of two patients with hereditary nephritis.
Thorner PS, Baumal R, Eddy A, Marrano PM
Prolongation of acute renal failure in two patients with hemolytic-uremic syndrome due to excessive plasma infusion therapy.
Eddy AA, Geary DF, Balfe JW, Clark WF, Baumal R
Interstitial nephritis induced by protein-overload proteinuria.
Characterization of the NC1 domain of collagen type IV in glomerular basement membranes (GBM) and of antibodies to GBM in a patient with anti-GBM nephritis.
Thorner PS, Baumal R, Eddy A, Marrano P
Identification of lymphohemopoietic cells in the kidneys of normal rats.
Eddy AA, Crary GS, Michael AF
Subtotal nephrectomy in the rabbit: a model of chronic hypercalcemia, nephrolithiasis, and obstructive nephropathy.
Eddy AA, Falk RJ, Sibley RK, Hostetter TH
Renal allograft failure due to recurrent dense intramembranous deposit disease.
Eddy A, Sibley R, Mauer SM, Kim Y
The distribution of the CR3 receptor on human cells and tissue as revealed by a monoclonal antibody.
Eddy A, Newman SL, Cosio F, LeBien T, Michael A
T32 DK07662 (Eddy PI). NIH/NRSA, Pediatric Nephrology Training Program, $274,895 current year. (2006-2016). The goal is to train academic pediatric nephrologists.
N/A (Okamura PI, Eddy Co-PI). Cystinosis Research Foundation, "Elucidating the Role of Cystinosin-Deficient Macrophages in Nephropathic Cystinosis", $218,966/2 years. (2011-2013). The goal of this project is to investigate the hypothesis that cystinosin deficiency leads to macrophage dysfunction that contributes to the pathogenesis of chronic kidney disease.
Pilot and Feasibility Grant (Eddy PI). Washington Global Health Alliance, Impact of Kidney Dysfunction on Mortality Rates in Ugandan Children Hospitalized with Acute Infections. $75,000. (2007-2010). The goal of this project is to establish a mechanism to evaluate renal function for children admitted to Mulago hospital with pneumonia, malaria and gastroenteritis and to determine the impact of renal failure on acute mortality rates.Honours & Awards
Elected to the Council of the International Society of Pediatric Nephrology (1995-2001) and the International Society of Nephrology (2009-2015).
Scientific Program Committee Co-chair for triannual congresses on the International Society of Pediatric Nephrology in 1989, 2011 and 2013.
First recipient of The Robert O. Hickman Endowed Chair in Pediatric Nephrology, University of Washington (2007-2012).Research Group Members