BCCHR Researchers Find a Researcher

Allison Eddy

MD

Investigator, BC Children's Hospital

Chronic kidney disease (CKD) is a significant and growing public health problem. It is currently estimated that 13% of the adult population has CKD and it confers a 5-fold increased risk of premature cardiovascular disease and death. Those who survive long enough eventually require renal replacement therapy with dialysis or a kidney transplant. Many of the risk factors for CKD begin in childhood. a patient develops CKD, the pathological changes that worsen dysfunction are similar in all kidney diseases, and are characterized by a process of ongoing scarring or fibrosis. Despite tremendous progress in our understanding of the causes and consequences of CKD, effective therapies are unknown. Using experimental models of CKD, our studies are designed to investigate how specific cells and molecules mediate kidney fibrosis, with the ultimate goal of translating our findings into new human therapies.

Academic Affiliations

Professor Emeritus/a, Division of Nephrology, Department of Pediatrics, Faculty of Medicine, University of British Columbia
Research Theme: Childhood Diseases

Contact Information

Location

4500 Oak St, Vancouver, BC, Canada, V6H 3N1

(604) 875-2315

allison.eddy@cw.bc.ca

Patient and caregiver perspectives on mental health in children and adolescents with chronic kidney disease

Clinical Kidney Journal

Torrisi, L.G. and van Zwieten, A. and Guha, C. and Kerr, M. and Sluiter, A. and Hughes, A. and Craig, J.C. and Sinha, A. and Dart, A. and Eddy, A.A. and Yap, H.-K. and Alexander, S.I. and Furth, S.L. and Kausman, J. and Jaure, A.

DOI: 10.1093/ckj/sfaf067

Patient, Parental, and Health Professional Perspectives on Growth in Children With CKD

American Journal of Kidney Diseases

Wu, J.G. and Guha, C. and Hughes, A. and Torrisi, L.G. and Craig, J.C. and Sinha, A. and Dart, A. and Eddy, A.A. and Bockenhauer, D. and Yap, H.-K. and Groothoff, J. and Alexander, S.I. and Furth, S.L. and Samuel, S. and Carter, S.A. and Walker, A. and Kausman, J. and Jaure, A.

DOI: 10.1053/j.ajkd.2024.06.016

Tubulointerstitial Nephritis in Children

Pediatric Kidney Disease

Verghese, P.S. and Luckritz, K.E. and Eddy, A.A.

DOI: 10.1007/978-3-031-11665-0_42

Lessons learned from regional training of paediatric nephrology fellows in Africa

Pediatric Nephrology

McCulloch, M.I. and Argent, A.C. and Morrow, B. and Nourse, P. and Coetzee, A. and Du Buisson, C. and Reddy, D. and Buckley, J. and Sinclair, P.J. and Gajjar, P. and Semanska, L. and Eddy, A. and Feehally, J. and Cano, F. and Warady, B.A.

DOI: 10.1007/s00467-023-06022-9

Child and caregiver perspectives on access to psychosocial and educational support in pediatric chronic kidney disease: a focus group study

Pediatric Nephrology

Zhang, Y. and Gutman, T. and Tong, A. and Craig, J.C. and Sinha, A. and Dart, A. and Eddy, A.A. and Gipson, D.S. and Bockenhauer, D. and Yap, H.-K. and Groothoff, J. and Zappitelli, M. and J.A.Webb, N. and Alexander, S.I. and Furth, S. and Samuel, S. and Blydt-Hansen, T.D. and Dionne, J. and Michael, M. and Wenderfer, S.E. and Winkelmayer, W.C. and McTaggart, S. and Walker, A. and Zimmerman, C.T. and Ralph, A.F. and Ju, A. and James, L.J. and Hanson, C.S.

DOI: 10.1007/s00467-022-05551-z

Perspectives of Clinicians on Shared Decision Making in Pediatric CKD: A Qualitative Study

American Journal of Kidney Diseases

Kerklaan, J. and Hanson, C.S. and Carter, S. and Tong, A. and Sinha, A. and Dart, A. and Eddy, A.A. and Guha, C. and Gipson, D.S. and Bockenhauer, D. and Hannan, E. and Yap, H.-K. and Groothoff, J. and Zappitelli, M. and Amir, N. and Alexander, S.I. and Furth, S.L. and Samuel, S. and Gutman, T. and Craig, J.C.

DOI: 10.1053/j.ajkd.2021.12.009

Impact of training nephrologists from developing nations and strategies for sustaining a training program in its fourth decade.

Kidney international

Okpechi IG and Eddy AA and Jha V and Jacob T and Dupuis S and Harris DC

DOI: 10.1016/j.kint.2021.02.029 PubMed: 33711332

03 / 2021

Patient and caregiver perspectives on blood pressure in children with chronic kidney disease

Nephrology Dialysis Transplantation

Wu, J.G.-A. and Tong, A. and Evangelidis, N. and Manera, K.E. and Hanson, C.S. and Baumgart, A. and Amir, N. and Sinha, A. and Dart, A. and Eddy, A.A. and Guha, C. and Gipson, D.S. and Bockenhauer, D. and Yap, H.-K. and Groothoff, J. and Zappitelli, M. and Alexander, S.I. and Furth, S.L. and Samuel, S. and Carter, S.A. and Walker, A. and Kausman, J. and Martinez-Martin, D. and Gutman, T. and Craig, J.C.

DOI: 10.1093/ndt/gfab194

Developing Consensus-Based Outcome Domains for Trials in Children and Adolescents With CKD: An International Delphi Survey.

American journal of kidney diseases : the official journal of the National Kidney Foundation

Logeman C and Guha C and Howell M and Hanson CS and Craig JC and Samuel S and Zappitelli M and Matsuda-Abedini M and Dart A and Furth S and Eddy A and Groothoff J and Yap HK and Tong A

DOI: 10.1053/j.ajkd.2020.03.014 PubMed: 32654889

07 / 2020

Establishing core outcome domains in pediatric kidney disease: report of the Standardized Outcomes in Nephrology-Children and Adolescents (SONG-KIDS) consensus workshops.

Kidney international

Hanson CS and Craig JC and Logeman C and Sinha A and Dart A and Eddy AA and Guha C and Gipson DS and Bockenhauer D and Yap HK and Groothoff J and Zappitelli M and Webb NJA and SONG-Kids consensus workshops investigators

DOI: 10.1016/j.kint.2020.05.054 PubMed: 32628942

07 / 2020

Drug-induced tubulointerstitial nephritis: hypersensitivity and necroinflammatory pathways

Pediatric Nephrology

Eddy, A.A.

DOI: 10.1007/s00467-019-04207-9

The Canadian childhood nephrotic syndrome (CHILDNEPH) study: report on mid-study feasibility, recruitment and main measures.

BMC nephrology

Samuel SM and Dart A and Filler G and Bitzan M and Pinsk M and Mammen C and Nettel-Aguirre A and Perinpanayagam MA and Takano T and Chanchlani R and Zappitelli M and other members of the Canadian Childhood Nephrotic Syndrome Project Team

DOI: 10.1186/s12882-019-1320-3 PubMed: 31088399

05 / 2019

Global Health Training Opportunities in North American Nephrology Fellowships.

Kidney international reports

Rope R and Perl J and Anand S and International Society of Nephrology North American and Caribbean Regional Board

DOI: 10.1016/j.ekir.2019.04.019 PubMed: 31384697

05 / 2019

Identifying Important Outcomes for Young People With CKD and Their Caregivers: A Nominal Group Technique Study.

American journal of kidney diseases : the official journal of the National Kidney Foundation

Hanson CS and Gutman T and Craig JC and Bernays S and Raman G and Zhang Y and James LJ and Ralph AF and Ju A and Manera KE and Teixeira-Pinto A and Viecelli AK and Alexander SI and Tong A

DOI: 10.1053/j.ajkd.2018.12.040 PubMed: 30885704

03 / 2019

Implementing core outcomes in kidney disease: report of the Standardized Outcomes in Nephrology (SONG) implementation workshop.

Kidney international

Tong A and Manns B and Wang AYM and Hemmelgarn B and Wheeler DC and Gill J and Tugwell P and Pecoits-Filho R and Crowe S and Harris T and Van Biesen W and Winkelmayer WC and Levin A and SONG Implementation Workshop Investigators

DOI: 10.1016/j.kint.2018.08.018 PubMed: 30360959

10 / 2018

Child and Parental Perspectives on Communication and Decision Making in Pediatric CKD: A Focus Group Study.

American journal of kidney diseases : the official journal of the National Kidney Foundation

Gutman T and Hanson CS and Bernays S and Craig JC and Sinha A and Dart A and Eddy AA and Gipson DS and Bockenhauer D and Yap HK and Groothoff J and Zappitelli M and Webb NJA and Tong A

DOI: 10.1053/j.ajkd.2018.05.005 PubMed: 29980375

07 / 2018

Does specialist physician supply affect pediatric asthma health outcomes?

BMC health services research

Filler G and Kovesi T and Bourdon E and Jones SA and Givelichian L and Rockman-Greenberg C and Gilliland J and Williams M and Orrbine E and Piedboeuf B and Paediatric Chairs of Canada Mark Bernstein

DOI: 10.1186/s12913-018-3084-z PubMed: 29622002

04 / 2018

Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy

Physiological Reports

Maydan, O. and McDade, P.G. and Liu, Y. and Wu, X.-R. and Matsell, D.G. and Eddy, A.A.

DOI: 10.14814/phy2.13654

Range and Heterogeneity of Outcomes in Randomized Trials of Pediatric Chronic Kidney Disease

Journal of Pediatrics

Chong, L.S.H. and Sautenet, B. and Tong, A. and Hanson, C.S. and Samuel, S. and Zappitelli, M. and Dart, A. and Furth, S. and Eddy, A.A. and Groothoff, J. and Webb, N.J.A. and Yap, H.-K. and Bockenhauer, D. and Sinha, A. and Alexander, S.I. and Goldstein, S.L. and Gipson, D.S. and Raman, G. and Craig, J.C.

DOI: 10.1016/j.jpeds.2017.03.034

Interstitial nephritis in children

Pediatric Kidney Disease Second Edition

Verghese, P.S. and Luckritz, K.E. and Eddy, A.A.

DOI: 10.1007/978-3-662-52972-0_38

Standardised Outcomes in Nephrology-Children and Adolescents (SONG-Kids): A protocol for establishing a core outcome set for children with chronic kidney disease

Trials

Tong, A. and Samuel, S. and Zappitelli, M. and Dart, A. and Furth, S. and Eddy, A. and Groothoff, J. and Webb, N.J.A. and Yap, H.-K. and Bockenhauer, D. and Sinha, A. and Alexander, S.I. and Goldstein, S.L. and Gipson, D.S. and Hanson, C.S. and Evangelidis, N. and Crowe, S. and Harris, T. and Hemmelgarn, B.R. and Manns, B. and Gill, J. and Tugwell, P. and Van Biesen, W. and Wheeler, D.C. and Winkelmayer, W.C. and Craig, J.C.

DOI: 10.1186/s13063-016-1528-5

The impact of small kidneys

Pediatric Nephrology

Matsell, D.G. and Cojocaru, D. and Matsell, E.W. and Eddy, A.A.

DOI: 10.1007/s00467-015-3079-5

Cysteamine modulates oxidative stress and blocks myofibroblast activity in CKD

Journal of the American Society of Nephrology

Okamura, D.M. and Bahrami, N.M. and Ren, S. and Pasichnyk, K. and Williams, J.M. and Gangoiti, J.A. and Lopez-Guisa, J.M. and Yamaguchi, I. and Barshop, B.A. and Duffield, J.S. and Eddy, A.A.

DOI: 10.1681/ASN.2012090962

Overview of the cellular and molecular basis of kidney fibrosis

Kidney International Supplements

Eddy, A.A.

DOI: 10.1038/kisup.2014.2

The Canadian Childhood Nephrotic Syndrome (CHILDNEPH) project: Overview of design and methods

Canadian Journal of Kidney Health and Disease

Samuel, S. and Scott, S. and Morgan, C. and Dart, A. and Mammen, C. and Parekh, R. and Nettel-Aguirre, A. and Eddy, A. and Flynn, R. and Pinsk, M. and Wade, A. and Arora, S. and Benoit, G. and Bitzan, M. and Erickson, R. and Feber, J. and Filler, G. and Geier, P. and Girardin, C. and Grisaru, S. and Tee, J. and Kemp, K. and Zappitelli, M.

DOI: 10.1186/2054-3581-1-17

Social paediatrics: From 'lip service' to the health and well-being of Canada's children and youth.

Daneman D and Kellner J and Bernstein M and Dow K and Dugas MA and Duffy C and Eddy A and Filler G and Frappier JY and Gilmour S and Givelichian L and Huang L and Rockman-Greenberg C and Shevell M and Vardy C and Walti H and Orrbine E and Williams M

PubMed: 24421706

08 / 2013

Rising part-time work in the academic pediatric workforce in Canada.

Filler G and Givelichian L and Walti H and Piedboeuf B and Pediatric Chairs of Canada

DOI: 10.1016/j.jpeds.2013.04.040 PubMed: 23885849

08 / 2013

Acute kidney injury and its association with in-hospital mortality among children with acute infections

Pediatric Nephrology

Imani, P.D. and Odiit, A. and Hingorani, S.R. and Weiss, N.S. and Eddy, A.A.

DOI: 10.1007/s00467-013-2544-2

The origin of scar-forming kidney myofibroblasts

Nature Medicine

Eddy, A.A.

DOI: 10.1038/nm.3299

Social paediatrics: From 'lip service' to the health and well-being of Canada's children and youth

Paediatrics and Child Health (Canada)

Daneman, D. and Kellner, J. and Bernstein, M. and Dow, K. and Dugas, M.A. and Duffy, C. and Eddy, A. and Filler, G. and Frappier, J.-Y. and Gilmour, S. and Givelichian, L. and Huang, L. and Rockman-Greenberg, C. and Shevell, M. and Vardy, C. and Walti, H. and Orrbine, E. and Williams, M.

Mannose Receptor 2 Attenuates Renal Fibrosis

Journal of the American Society of Nephrology

DOI: 10.1681/asn.2011030310

02 / 2012

Critical and honest conversations: The evidence behind the "choosing Wisely" campaign recommendations by the American society of nephrology

Clinical Journal of the American Society of Nephrology

Williams, A.W. and Dwyer, A.C. and Eddy, A.A. and Fink, J.C. and Jaber, B.L. and Linas, S.L. and Michael, B. and O'Hare, A.M. and Schaefer, H.M. and Shaffer, R.N. and Trachtman, H. and Weiner, D.E. and Falk, R.J.

DOI: 10.2215/CJN.04970512

Investigating mechanisms of chronic kidney disease in mouse models

Pediatric Nephrology

Eddy, A.A. and Lpez-Guisa, J.M. and Okamura, D.M. and Yamaguchi, I.

DOI: 10.1007/s00467-011-1938-2

Albumin-induced apoptosis of glomerular parietal epithelial cells is modulated by extracellular signal-regulated kinase 1/2

Nephrology Dialysis Transplantation

Chang, A.M. and Ohse, T. and Krofft, R.D. and Wu, J.S. and Eddy, A.A. and Pippin, J.W. and Shankland, S.J.

DOI: 10.1093/ndt/gfr483

Vascular endothelial cadherin modulates renal interstitial fibrosis

Nephron - Experimental Nephrology

Yamaguchi, I. and Tchao, B.N. and Burger, M.L. and Yamada, M. and Hyodo, T. and Giampietro, C. and Eddy, A.A.

DOI: 10.1159/000332026

Nicotinic acetylcholine receptor a1 promotes calpain-1 activation and macrophage inflammation in hypercholesterolemic nephropathy

Laboratory Investigation

Zhang, G. and Thomas, A.L. and Marshall, A.L. and Kernan, K.A. and Su, Y. and Zheng, Y. and Takano, J. and Saido, T.C. and Eddy, A.A.

DOI: 10.1038/labinvest.2010.135

The TGF- route to renal fibrosis is not linear: The miR-21 viaduct

Journal of the American Society of Nephrology

Eddy, A.A.

DOI: 10.1681/ASN.2011070698

Scraping fibrosis: UMODulating renal fibrosis

Nature Medicine

Eddy, A.A.

DOI: 10.1038/nm0511-553

Galectin-3 preserves renal tubules and modulates extracellular matrix remodeling in progressive fibrosis

American Journal of Physiology - Renal Physiology

Okamura, D.M. and Pasichnyk, K. and Lopez-Guisa, J.M. and Collins, S. and Hsu, D.K. and Liu, F.-T. and Eddy, A.A.

DOI: 10.1152/ajprenal.00326.2010

Vitronectin accumulates in the interstitium but minimally impacts fibrogenesis in experimental chronic kidney disease

American Journal of Physiology - Renal Physiology

Lpez-Guisa, J.M. and Rassa, A.C. and Cai, X. and Collins, S.J. and Eddy, A.A.

DOI: 10.1152/ajprenal.00701.2010

Systemic Lupus Erythematosus

Textbook of Pediatric Rheumatology

Silverman, E. and Eddy, A.

DOI: 10.1016/B978-1-4160-6581-4.10021-4

Phase 1 Trial of Adalimumab in Focal Segmental Glomerulosclerosis (FSGS): II. Report of the FONT (Novel Therapies for Resistant FSGS) Study Group

American Journal of Kidney Diseases

Joy, M.S. and Gipson, D.S. and Powell, L. and MacHardy, J. and Jennette, J.C. and Vento, S. and Pan, C. and Savin, V. and Eddy, A. and Fogo, A.B. and Kopp, J.B. and Cattran, D. and Trachtman, H.

DOI: 10.1053/j.ajkd.2009.08.019

Round 3 at JASN (2001 to 2007): Recollections of the third editorial team

Journal of the American Society of Nephrology

Couser, W. and Eddy, A.A. and Hill, C.

DOI: 10.1681/ASN.2009101074

Serine proteases, inhibitors and receptors in renal fibrosis.

Eddy AA

PubMed: 19350108

04 / 2009

CD36 regulates oxidative stress and inflammation in hypercholesterolemic CKD

Journal of the American Society of Nephrology

Okamura, D.M. and Pennathur, S. and Pasichnyk, K. and Lpez-Guisa, J.M. and Collins, S. and Febbraio, M. and Heinecke, J. and Eddy, A.A.

DOI: 10.1681/ASN.2008010009

Phase I trial of rosiglitazone in FSGS: I. Report of the font study group

Clinical Journal of the American Society of Nephrology

Joy, M.S. and Gipson, D.S. and Dike, M. and Powell, L. and Thompson, A. and Vento, S. and Eddy, A. and Fogo, A.B. and Kopp, J.B. and Cattran, D. and Trachtman, H.

DOI: 10.2215/CJN.02310508

Serine proteases, inhibitors and receptors in renal fibrosis

Thrombosis and Haemostasis

Eddy, A.A.

DOI: 10.1160/TH08-12-0779

A novel signaling pathway: Fibroblast nicotinic receptor a1 binds urokinase and promotes renal fibrosis

Journal of Biological Chemistry

Zhang, G. and Kernan, K.A. and Thomas, A. and Collins, S. and Song, Y. and Li, L. and Zhu, W. and LeBoeuf, R.C. and Eddy, A.A.

DOI: 10.1074/jbc.M109.010249

Interstitial Nephritis

Comprehensive Pediatric Nephrology

Verghese, P.S. and Luckritz, K.E. and Eddy, A.A.

DOI: 10.1016/B978-0-323-04883-5.50040-4

Macrophage diversity in renal injury and repair

Journal of Clinical Investigation

Ricardo, S.D. and Van Goor, H. and Eddy, A.A.

DOI: 10.1172/JCI36150

Angiotensin converting enzyme inhibitor but not angiotensin receptor blockade or statin ameliorates murine adriamycin nephropathy

Kidney International

Tang, S.C.W. and Leung, J.C.K. and Chan, L.Y.Y. and Eddy, A.A. and Lai, K.N.

DOI: 10.1038/sj.ki.5002674

Urokinase and its receptors in chronic kidney disease

Frontiers in Bioscience

Zhang, G. and Eddy, A.A.

DOI: 10.2741/3093

Endogenous urokinase lacks antifibrotic activity during progressive renal injury

American Journal of Physiology - Renal Physiology

Yamaguchi, I. and Lopez-Guisa, J.M. and Cai, X. and Collins, S.J. and Okamura, D.M. and Eddy, A.A.

DOI: 10.1152/ajprenal.00380.2006

Atherogenic scavenger receptor modulation in the tubulointerstitium in response to chronic renal injury

American Journal of Physiology - Renal Physiology

Okamura, D.M. and Lpez-Guisa, J.M. and Koelsch, K. and Collins, S. and Eddy, A.A.

DOI: 10.1152/ajprenal.00063.2007

Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: Role of plasmin-activated signals

Journal of the American Society of Nephrology

Zhang, G. and Kernan, K.A. and Collins, S.J. and Cai, X. and Lpez-Guisa, J.M. and Degen, J.L. and Shvil, Y. and Eddy, A.A.

DOI: 10.1681/ASN.2006080886

JASN moves on

Journal of the American Society of Nephrology

Couser, W.G. and Hill, C. and Eddy, A.A.

DOI: 10.1681/ASN.2007040415

Plasminogen activator inhibitor-1 deficiency has renal benefits but some adverse systemic consequences in diabetic mice.

Collins SJ and Alexander SL and Lopez-Guisa JM and Cai X and Maruvada R and Chua SC and Zhang G and Okamura DM and Matsuo S and Eddy AA

PubMed: 16735799

Plasminogen activator inhibitor-1 in chronic kidney disease: Evidence and mechanisms of action

Journal of the American Society of Nephrology

Eddy, A.A. and Fogo, A.B.

DOI: 10.1681/ASN.2006050503

Subepithelial humps and microthrombi: Looking for a mechanism

American Journal of Kidney Diseases

Simon, D. and Finn, L. and Eddy, A.

DOI: 10.1053/j.ajkd.2005.07.052

Plasminogen activator inhibitor-1 deficiency has renal benefits but some adverse systemic consequences in diabetic mice

Nephron - Experimental Nephrology

Collins, S.J. and Alexander, S.L. and Lopez-Guisa, J.M. and Cai, X. and Maruvada, R. and Chua, S.C. and Zhang, G. and Okamura, D.M. and Matsuo, S. and Eddy, A.A.

DOI: 10.1159/000093673

Chronic kidney disease progression

Journal of the American Society of Nephrology

Eddy, A.A. and Neilson, E.G.

DOI: 10.1681/ASN.2006070704

Ramping up endogenous defences against chronic kidney disease

Nephrology Dialysis Transplantation

Eddy, A.A.

DOI: 10.1093/ndt/gfl102

Progression in chronic kidney disease

Advances in Chronic Kidney Disease

Eddy, A.A.

DOI: 10.1053/j.ackd.2005.07.011

Multifunctionality of PAI-1 in fibrogenesis: Evidence from obstructive nephropathy in PAI-1-overexpressing mice

Kidney International

Matsuo, S. and Lpez-Guisa, J.M. and Cai, X. and Okamura, D.M. and Alpers, C.E. and Bumgarner, R.E. and Peters, M.A. and Zhang, G. and Eddy, A.A.

DOI: 10.1111/j.1523-1755.2005.00327.x

Can renal fibrosis be reversed?

Pediatric Nephrology

Eddy, A.A.

DOI: 10.1007/s00467-005-1995-5

Erratum: Multifunctionality of PAI-1 in fibrogenesis: Evidence from obstructive nephropathy in PAI-1-overexpressing mice (Kidney International (2005) 67 (2221-2238))

Kidney International

Matsuo, S. and Lpez-Guisa, J.M. and Cai, X. and Okamura, D.M. and Alpers, C.E. and Bumgarner, R.E. and Peters, M.A. and Zhang, G. and Eddy, A.A.

DOI: 10.1111/j.1523-1755.2005.90682.x

Why is proteinuria an ominous biomarker of progressive kidney disease?

Kidney International, Supplement

Zandi-Nejad, K. and Eddy, A.A. and Glassock, R.J. and Brenner, B.M.

DOI: 10.1111/j.1523-1755.2004.09220.x PubMed: 15485426

Mitogenic signaling of urokinase receptor-deficient kidney fibroblasts: Actions of an alternative urokinase receptor and LDL receptor-related protein

Journal of the American Society of Nephrology

Zhang, G. and Cai, X. and Lpez-Guisa, J.M. and Collins, S.J. and Eddy, A.A.

DOI: 10.1097/01.ASN.0000135057.41526.2C

Expression of nephrin in acquired forms of nephrotic syndrome in childhood

Pediatric Nephrology

Hingorani, S.R. and Finn, L.S. and Kowalewska, J. and McDonald, R.A. and Eddy, A.A.

DOI: 10.1007/s00467-003-1346-3

Exogenous bone morphogenetic protein-7 fails to attenuate renal fibrosis in rats with overload proteinuria

Nephron - Experimental Nephrology

Ikeda, Y. and Jung, Y.O. and Kim, H. and Oda, T. and Lpez-Guisa, J. and Maruvada, R. and Diamond, D.L. and Martin, K.J. and Wing, D. and Cai, X. and Eddy, A.A.

DOI: 10.1159/000079177

The NPHP1 gene deletion associated with juvenile nephronophthisis is present in a subset of individuals with Joubert syndrome

American Journal of Human Genetics

Parisi, M.A. and Bennett, C.L. and Eckert, M.L. and Dobyns, W.B. and Gleeson, J.G. and Shaw, D.W.W. and McDonald, R. and Eddy, A. and Chance, P.F. and Glass, I.A.

DOI: 10.1086/421846

Proteinuria and interstitial injury

Nephrology Dialysis Transplantation

Eddy, A.A.

DOI: 10.1093/ndt/gfg533

Urokinase receptor deficiency accelerates renal fibrosis in obstructive nephropathy

Journal of the American Society of Nephrology

Zhang, G. and Kim, H. and Cai, X. and Lpez-Guisa, J.M. and Alpers, C.E. and Liu, Y. and Carmeliet, P. and Eddy, A.A.

DOI: 10.1097/01.ASN.0000064292.37793.FB

Urokinase receptor modulates cellular and angiogenic responses in obstructive nephropathy

Journal of the American Society of Nephrology

Zhang, G. and Kim, H. and Cai, X. and Lopez-Guisa, J.M. and Carmeliet, P. and Eddy, A.A.

DOI: 10.1097/01.ASN.0000064701.70231.3F

Nephrotic syndrome in childhood

Lancet

Eddy, A.A. and Symons, J.M.

DOI: 10.1016/S0140-6736(03)14184-0

Longterm followup of childhood lupus nephritis.

Hagelberg S and Lee Y and Bargman J and Mah G and Schneider R and Laskin C and Eddy A and Gladman D and Urowitz M and Hebert D and Silverman E

PubMed: 12465165

12 / 2002

Plasminogen activator inhibitor-1 and the kidney.

Eddy AA

PubMed: 12110504

08 / 2002

An introduction to Frontiers in Nephrology

Journal of the American Society of Nephrology

Eddy, A.A. and Couser, W.G.

DOI: 10.1097/01.ASN.0000026725.09795.90

Plasminogen activator inhibitor-1 and the kidney

American Journal of Physiology - Renal Physiology

Eddy, A.A.

DOI: 10.1152/ajprenal.00032.2002

And we're off!

Journal of the American Society of Nephrology

Couser, W.G. and Eddy, A.

Longterm followup of childhood lupus nephritis

Journal of Rheumatology

Hagelberg, S. and Lee, Y. and Bargman, J. and Mah, G. and Schneider, R. and Laskin, C. and Eddy, A. and Gladman, D. and Urowitz, M. and Hebert, D. and Silverman, E.

TIMP-1 deficiency does not attenuate interstitial fibrosis in obstructive nephropathy.

Kim H and Oda T and Lpez-Guisa J and Wing D and Edwards DR and Soloway PD and Eddy AA

PubMed: 11274235

04 / 2001

Role of cellular infiltrates in response to proteinuria.

Eddy A

PubMed: 11158857

01 / 2001

PAI-1 deficiency attenuates the fibrogenic response to ureteral obstruction

Kidney International

Oda, T. and Jung, Y.O. and Kim, H.S. and Cai, X. and Lpez-Guisa, J.M. and Ikeda, Y. and Eddy, A.A.

DOI: 10.1046/j.1523-1755.2001.030002587.x

TIMP-1 deficiency does not attenuate interstitial fibrosis in obstructive nephropathy

Journal of the American Society of Nephrology

Kim, H. and Oda, T. and Lpez-Guisa, J. and Wing, D. and Edwards, D.R. and Soloway, P.D. and Eddy, A.A.

Role of cellular infiltrates in response to proteinuria

American Journal of Kidney Diseases

Eddy, A.A.

DOI: 10.1053/ajkd.2001.20735

Mast cells find their way to the kidney

Kidney International

Eddy, A.A.

DOI: 10.1046/j.1523-1755.2001.00811.x

Molecular basis of renal fibrosis

Pediatric Nephrology

Eddy, A.A.

DOI: 10.1007/s004670000461

Evaluation and management of proteinuria and nephrotic syndrome in children: Recommendations from a pediatric nephrology panel established at the National Kidney Foundation Conference on Proteinuria, Albuminuria, Risk, Assessment, Detection, and Elimination (PARADE)

Pediatrics

Hogg, R.J. and Portman, R.J. and Milliner, D. and Lemley, K.V. and Eddy, A. and Ingelfinger, J.

DOI: 10.1542/peds.105.6.1242

Interstitial fibrosis in mice with overload proteinuria: Deficiency of TIMP-1 is not protective

Kidney International

Eddy, A.A. and Kim, H. and Lpez-Guisa, J. and Oda, T. and Soloway, P.D. and McCulloch, L. and Liu, E. and Wing, D.

DOI: 10.1046/j.1523-1755.2000.00208.x

A morbid course in a girl with mixed connective tissue disease

Pediatric Nephrology

Essalah, A.A. and Eddy, A.A.

DOI: 10.1007/s004670050562

Renal remodelling in dietary protein modified rat polycystic kidney disease

Pediatric Nephrology

Bankovic-Calic, N. and Eddy, A. and Sareen, S. and Ogborn, M.R.

DOI: 10.1007/s004670050744

Tubulointerstitial nephritis and uveitis in children and adolescents. Four new cases and a review of the literature

Pediatric Nephrology

Vohra, S. and Eddy, A. and Laxer, R.M. and Levin, A.V. and Taylor, G.

DOI: 10.1007/s004670050634

Risk of hemolytic uremic syndrome after sporadic Escherichia coli O157:H7 infection: Results of a Canadian collaborative study

The Journal of Pediatrics

DOI: 10.1016/s0022-3476(98)70303-8

05 / 1998

The nephrotic syndrome: from the simple to the complex.

Eddy AA and Schnaper HW

PubMed: 9613871

05 / 1998

Failure of antioxidant therapy to attenuate interstitial disease in rats with reversible nephrotic syndrome.

Drukker A and Eddy AA

PubMed: 9527400

02 / 1998

Failure of antioxidant therapy to attenuate interstitial disease in rats with reversible nephrotic syndrome

Journal of the American Society of Nephrology

Drukker, A. and Eddy, A.A. and Mcculloch, L. and Liu, E.

Interstitial fibrosis in hypercholesterolemic rats: Role of oxidation, matrix synthesis, and proteolytic cascades

Kidney International

Eddy, A.A. and Liu, E. and Mcculloch, L.

DOI: 10.1046/j.1523-1755.1998.00889.x

Single photon emission computed tomography scanning in childhood systemic lupus erythematosus

Journal of Rheumatology

Russo, R. and Gilday, D. and Laxer, R.M. and Eddy, A. and Silverman, E.D.

The nephrotic syndrome: From the simple to the complex

Seminars in Nephrology

Eddy, A.A. and William Schnaper, H.

Molecular insights into renal interstitial fibrosis.

Eddy AA

PubMed: 8989727

12 / 1996

Expression of genes that promote renal interstitial fibrosis in rats with proteinuria.

Eddy AA

PubMed: 8731195

05 / 1996

Molecular insights into renal interstitial fibrosis

Journal of the American Society of Nephrology

Eddy, A.A.

Antiribosomal P antibodies in pediatric patients with systemic lupus erythematosus and psychosis

Arthritis and Rheumatism

Press, J. and Palayew, K. and Laxer, R.M. and Elkon, K. and Eddy, A. and Rakoff, D. and Silverman, E.D.

DOI: 10.1002/art.1780390420

Interstitial inflammation and fibrosis in rats with diet-induced hypercholesterolemia

Kidney International

Eddy, A.A.

DOI: 10.1038/ki.1996.421

Expression of genes that promote renal interstitial fibrosis in rats with proteinuria

Kidney International Supplement

Eddy, A.A.

Expression and function of monocyte chemoattractant protein-1 in experimental nephrotic syndrome

Clinical Immunology and Immunopathology

Eddy, A.A. and Warren, J.S.

DOI: 10.1006/clin.1996.0023

Renal expression of genes that promote interstitial inflammation and fibrosis in rats with protein-overload proteinuria

Kidney International

Eddy, A.A. and Giachelli, C.M.

DOI: 10.1038/ki.1995.218

Neurologic manifestations of pediatric systemic lupus erythematosus

Pediatric Neurology

Steinlin, M.I. and Blaser, S.I. and Gilday, D.L. and Eddy, A.A. and Logan, W.J. and Laxer, R.M. and Silverman, E.D.

DOI: 10.1016/0887-8994(95)00110-2

Interstitial macrophages as mediators of renal fibrosis

Experimental Nephrology

Eddy, A.A.

An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes

Molecular and Cellular Biology

Zhang, L. and Eddy, A. and Teng, Y.-T. and Fritzler, M. and Kluppel, M. and Melet, F. and Bernstein, A.

DOI: 10.1128/MCB.15.12.6961

Experimental insights into the tubulointerstitial disease accompanying primary glomerular lesions.

Eddy AA

PubMed: 7893992

12 / 1994

Xanthogranulomatous pyelonephritis in children. Etiology, pathogenesis, clinical and radiologic features, and management.

Levy M and Baumal R and Eddy AA

PubMed: 8200171

06 / 1994

Protein restriction reduces transforming growth factor-beta and interstitial fibrosis in nephrotic syndrome.

Eddy AA

PubMed: 8023968

06 / 1994

Protein restriction reduces transforming growth factor- and interstitial fibrosis in nephrotic syndrome

American Journal of Physiology - Renal Fluid and Electrolyte Physiology

Eddy, A.A.

Experimental insights into the tubulointerstitial disease accompanying primary glomerular lesions

Journal of the American Society of Nephrology

Eddy, A.A.

Xanthogranulomatous Pyelonephritis in Children: Etiology, Pathogenesis, Clinical and Radiologic Features, and Management

Clinical Pediatrics

Levy, M. and Baumal, R. and Eddy, A.A.

DOI: 10.1177/000992289403300609

Renal extracellular matrix accumulation in acute puromycin aminonucleoside nephrosis in rats.

Jones CL and Buch S and Post M and McCulloch L and Liu E and Eddy AA

PubMed: 1281619

12 / 1992

Tubulointerstitial nephritis

Pediatric Nephrology

Jones, C.L. and Eddy, A.A.

DOI: 10.1007/BF00866512

The contribution of antibody-mediated cytotoxicity and immune-complex formation to tubulointerstitial disease in passive Heymann nephritis

Clinical Immunology and Immunopathology

Eddy, A.A. and Ho, G.C. and Thorner, P.S.

DOI: 10.1016/0090-1229(92)90021-F

Renal extracellular matrix accumulation in acute puromycin aminonucleoside nephrosis in rats

American Journal of Pathology

Jones, C.L. and Buch, S. and Post, M. and McCulloch, L. and Liu, E. and Eddy, A.A.

Intrarenal distribution of clusterin following reduction of renal mass

Kidney International

Correa-Rotter, R. and Hostetter, T.H. and Manivel, J.C. and Eddy, A.A. and Rosenberg, M.E.

DOI: 10.1038/ki.1992.144

A relationship between proteinuria and acute tubulointerstitial disease in rats with experimental nephrotic syndrome.

Eddy AA and McCulloch L and Liu E and Adams J

PubMed: 2024704

05 / 1991

Presence of thyroid abnormalities in children with systemic lupus erythematosus

The Journal of Pediatrics

Eberhard, B.A. and Laxer, R.M. and Eddy, A.A. and Silverman, E.D.

DOI: 10.1016/S0022-3476(05)80741-3

Pulmonary Hemorrhage and Necrotizing Glomerulonephritis Without Glomerular Immune Deposits: Report of Two Cases

American Journal of Kidney Diseases

Jones, C.L. and Shields, M. and Eddy, A.A. and Baumal, R. and O'Neill, M. and Geary, D.F.

DOI: 10.1016/S0272-6386(12)80887-0

A relationship between proteinuria and acute tubulointerstitial disease in rats with experimental nephrotic syndrome

American Journal of Pathology

Eddy, A.A. and McCulloch, L. and Liu, E. and Adams, J.

Tubulointerstitial nephritis during the heterologous phase of nephrotoxic serum nephritis.

Eddy AA

PubMed: 1956493

Localization of clusterin in the epimembranous deposits of passive Heymann nephritis

Kidney International

Eddy, A.A. and Fritz, I.B.

DOI: 10.1038/ki.1991.29

Pathogenesis of interstitial fibrosis in chronic purine aminonucleoside nephrosis

Kidney International

Jones, C.L. and Buch, S. and Post, M. and Mcculloch, L. and Liu, E. and Eddy, A.A.

DOI: 10.1038/ki.1991.310

Tubulointerstitial nephritis during the heterologous phase of nephrotoxic serum nephritis

Nephron

Eddy, A.A.

DOI: 10.1159/000186569

Intraglomerular leukocyte recruitment during nephrotoxic serum nephritis in rats

Clinical Immunology and Immunopathology

Eddy, A.A. and McCulloch, L.M. and Adams, J.A.

DOI: 10.1016/0090-1229(90)90118-A

A study by immunofluorescence microscopy of the NC1 domain of collagen type IV in glomerular basement membranes of two patients with hereditary nephritis

Virchows Archiv A Pathological Anatomy and Histopathology

Thorner, P.S. and Baumal, R. and Eddy, A. and Marrano, P.M.

DOI: 10.1007/BF01678979

Coagulation abnormalities in chronic peritoneal dialysis

Pediatric Nephrology

Jones, C.L. and Andrew, M. and Eddy, A. and O'Neil, M. and Ish Shalom, N. and Balfe, J.W.

DOI: 10.1007/BF00858827

Interstitial nephritis induced by protein-overload proteinuria.

Eddy AA

PubMed: 2801886

10 / 1989

Characterization of the NC1 domain of collagen type IV in glomerular basement membranes (GBM) and of antibodies to GBM in a patient with anti-GBM nephritis.

Thorner PS and Baumal R and Eddy A and Marrano P

PubMed: 2706812

03 / 1989

Characterization of the NC1 domain of collagen type IV in glomerular basement membranes (GBM) and of antibodies to GBM in a patient with anti-GBM nephritis

Clinical Nephrology

Thorner, P.S. and Baumal, R. and Eddy, A. and Marrano, P.

Interstitial nephritis induced by protein-overload proteinuria

American Journal of Pathology

Eddy, A.A.

Prolongation of acute renal failure in two patients with hemolytic-uremic syndrome due to excessive plasma infusion therapy

Pediatric Nephrology

Eddy, A.A. and Geary, D.F. and Balfe, J.W. and Clark, W.F. and Baumal, R.

DOI: 10.1007/BF00850219

Acute tubulointerstitial nephritis associated with aminonucleoside nephrosis

Kidney International

Eddy, A.A. and Michael, A.F.

DOI: 10.1038/ki.1988.3

Demonstration by light microscopy of cytomegalovirus on a renal biopsy of a renal allograft recipient: Confirmation by immunohistochemistry and in situ hybridization

Nephron

Payton, D. and Thorner, P. and Eddy, A. and Yeger, H. and Baumal, R.

DOI: 10.1159/000184493

Identification of lymphohemopoietic cells in the kidneys of normal rats.

Eddy AA and Crary GS and Michael AF

PubMed: 3488687

08 / 1986

Subtotal nephrectomy in the rabbit: a model of chronic hypercalcemia, nephrolithiasis, and obstructive nephropathy.

Eddy AA and Falk RJ and Sibley RK and Hostetter TH

PubMed: 3711720

06 / 1986

Identification of lymphohemopoietic cells in the kidneys of normal rats

American Journal of Pathology

Eddy, A.A. and Crary, G.S. and Michael, A.F.

Subtotal nephrectomy in the rabbit: A model of chronic hypercalcemia, nephrolithiasis, and obstructive nephropathy

The Journal of Laboratory and Clinical Medicine

Eddy, A.A. and Falk, R.J. and Sibley, R.K. and Hostetter, T.H.

Pseudohermaphroditism, glomerulopathy, and Wilms tumor (Drash syndrome): Frequency in end-stage renal failure

The Journal of Pediatrics

Eddy, A.A. and Mauer, S.M.

DOI: 10.1016/S0022-3476(85)80076-7

Decreased plasma fibronectin levels in children with hemolytic-uremic syndrome

The American Journal of Medicine

Cosio, F.G. and Eddy, A. and Mentser, M.I. and Bergstein, J.M.

DOI: 10.1016/0002-9343(85)90394-8

Reply

The Journal of Pediatrics

Eddy, A. and Mauer, S.M.

DOI: 10.1016/S0022-3476(85)80211-0

Renal allograft failure due to recurrent dense intramembranous deposit disease.

Eddy A and Sibley R and Mauer SM and Kim Y

PubMed: 6380848

06 / 1984

The distribution of the CR3 receptor on human cells and tissue as revealed by a monoclonal antibody

Clinical Immunology and Immunopathology

Eddy, A. and Newman, S.L. and Cosio, F. and LeBien, T. and Michael, A.

DOI: 10.1016/0090-1229(84)90090-4

Renal allograft failure due to recurrent dense intramembranous deposit disease

Clinical Nephrology

Eddy, A. and Sibley, R. and Maurer, S.M. and Kim, Y.

Immune cell populations in cutaneous delayed-type hypersensitivity

Journal of Experimental Medicine

Platt, J.L. and Grant, B.W. and Eddy, A.A. and Michael, A.F.

DOI: 10.1084/jem.158.4.1227

Grants

T32 DK07662 (Eddy PI). NIH/NRSA, Pediatric Nephrology Training Program, $274,895 current year. (2006-2016). The goal is to train academic pediatric nephrologists.

N/A (Okamura PI, Eddy Co-PI). Cystinosis Research Foundation, "Elucidating the Role of Cystinosin-Deficient Macrophages in Nephropathic Cystinosis", $218,966/2 years. (2011-2013). The goal of this project is to investigate the hypothesis that cystinosin deficiency leads to macrophage dysfunction that contributes to the pathogenesis of chronic kidney disease.

Pilot and Feasibility Grant (Eddy PI). Washington Global Health Alliance, Impact of Kidney Dysfunction on Mortality Rates in Ugandan Children Hospitalized with Acute Infections. $75,000. (2007-2010). The goal of this project is to establish a mechanism to evaluate renal function for children admitted to Mulago hospital with pneumonia, malaria and gastroenteritis and to determine the impact of renal failure on acute mortality rates.

Honours & Awards

Appointed to the Order of Canada for her work and mentorship in pediatric nephrology and kidney fibrosis (2025).

Elected to the Council of the International Society of Pediatric Nephrology (1995-2001) and the International Society of Nephrology (2009-2015).

Scientific Program Committee Co-chair for triannual congresses on the International Society of Pediatric Nephrology in 1989, 2011 and 2013.

First recipient of The Robert O. Hickman Endowed Chair in Pediatric Nephrology, University of Washington (2007-2012).

Our Research

At BC Children’s, we are making discoveries that save lives and transform health care for children in our province and around the world. Our research portfolio includes basic, clinical, population, and public health research.

EXPLORE OUR RESEARCH

Allison Eddy

MD

Investigator, BC Children's Hospital

Academic Affiliations

Contact Information

Location

Publications

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Patient and caregiver perspectives on mental health in children and adolescents with chronic kidney disease

Patient, Parental, and Health Professional Perspectives on Growth in Children With CKD

Tubulointerstitial Nephritis in Children

Lessons learned from regional training of paediatric nephrology fellows in Africa

Child and caregiver perspectives on access to psychosocial and educational support in pediatric chronic kidney disease: a focus group study

Perspectives of Clinicians on Shared Decision Making in Pediatric CKD: A Qualitative Study

Impact of training nephrologists from developing nations and strategies for sustaining a training program in its fourth decade.

Patient and caregiver perspectives on blood pressure in children with chronic kidney disease

Developing Consensus-Based Outcome Domains for Trials in Children and Adolescents With CKD: An International Delphi Survey.

Establishing core outcome domains in pediatric kidney disease: report of the Standardized Outcomes in Nephrology-Children and Adolescents (SONG-KIDS) consensus workshops.

Drug-induced tubulointerstitial nephritis: hypersensitivity and necroinflammatory pathways

The Canadian childhood nephrotic syndrome (CHILDNEPH) study: report on mid-study feasibility, recruitment and main measures.

Global Health Training Opportunities in North American Nephrology Fellowships.

Identifying Important Outcomes for Young People With CKD and Their Caregivers: A Nominal Group Technique Study.

Implementing core outcomes in kidney disease: report of the Standardized Outcomes in Nephrology (SONG) implementation workshop.

Child and Parental Perspectives on Communication and Decision Making in Pediatric CKD: A Focus Group Study.

Does specialist physician supply affect pediatric asthma health outcomes?

Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy

Range and Heterogeneity of Outcomes in Randomized Trials of Pediatric Chronic Kidney Disease

Interstitial nephritis in children

Standardised Outcomes in Nephrology-Children and Adolescents (SONG-Kids): A protocol for establishing a core outcome set for children with chronic kidney disease

The impact of small kidneys

Cysteamine modulates oxidative stress and blocks myofibroblast activity in CKD

Overview of the cellular and molecular basis of kidney fibrosis

The Canadian Childhood Nephrotic Syndrome (CHILDNEPH) project: Overview of design and methods

Social paediatrics: From 'lip service' to the health and well-being of Canada's children and youth.

Rising part-time work in the academic pediatric workforce in Canada.

Acute kidney injury and its association with in-hospital mortality among children with acute infections

The origin of scar-forming kidney myofibroblasts

Social paediatrics: From 'lip service' to the health and well-being of Canada's children and youth

Mannose Receptor 2 Attenuates Renal Fibrosis

Critical and honest conversations: The evidence behind the "choosing Wisely" campaign recommendations by the American society of nephrology

Investigating mechanisms of chronic kidney disease in mouse models

Albumin-induced apoptosis of glomerular parietal epithelial cells is modulated by extracellular signal-regulated kinase 1/2

Vascular endothelial cadherin modulates renal interstitial fibrosis

Nicotinic acetylcholine receptor a1 promotes calpain-1 activation and macrophage inflammation in hypercholesterolemic nephropathy

The TGF- route to renal fibrosis is not linear: The miR-21 viaduct

Scraping fibrosis: UMODulating renal fibrosis

Galectin-3 preserves renal tubules and modulates extracellular matrix remodeling in progressive fibrosis

Vitronectin accumulates in the interstitium but minimally impacts fibrogenesis in experimental chronic kidney disease

Systemic Lupus Erythematosus

Phase 1 Trial of Adalimumab in Focal Segmental Glomerulosclerosis (FSGS): II. Report of the FONT (Novel Therapies for Resistant FSGS) Study Group

Round 3 at JASN (2001 to 2007): Recollections of the third editorial team

Serine proteases, inhibitors and receptors in renal fibrosis.

CD36 regulates oxidative stress and inflammation in hypercholesterolemic CKD

Phase I trial of rosiglitazone in FSGS: I. Report of the font study group

Serine proteases, inhibitors and receptors in renal fibrosis

A novel signaling pathway: Fibroblast nicotinic receptor a1 binds urokinase and promotes renal fibrosis

Interstitial Nephritis

Macrophage diversity in renal injury and repair

Angiotensin converting enzyme inhibitor but not angiotensin receptor blockade or statin ameliorates murine adriamycin nephropathy

Urokinase and its receptors in chronic kidney disease

Endogenous urokinase lacks antifibrotic activity during progressive renal injury

Atherogenic scavenger receptor modulation in the tubulointerstitium in response to chronic renal injury

Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: Role of plasmin-activated signals

JASN moves on

Plasminogen activator inhibitor-1 deficiency has renal benefits but some adverse systemic consequences in diabetic mice.

Plasminogen activator inhibitor-1 in chronic kidney disease: Evidence and mechanisms of action

Subepithelial humps and microthrombi: Looking for a mechanism

Plasminogen activator inhibitor-1 deficiency has renal benefits but some adverse systemic consequences in diabetic mice

Chronic kidney disease progression

Ramping up endogenous defences against chronic kidney disease

Progression in chronic kidney disease

Multifunctionality of PAI-1 in fibrogenesis: Evidence from obstructive nephropathy in PAI-1-overexpressing mice

Can renal fibrosis be reversed?

Erratum: Multifunctionality of PAI-1 in fibrogenesis: Evidence from obstructive nephropathy in PAI-1-overexpressing mice (Kidney International (2005) 67 (2221-2238))

Why is proteinuria an ominous biomarker of progressive kidney disease?

Mitogenic signaling of urokinase receptor-deficient kidney fibroblasts: Actions of an alternative urokinase receptor and LDL receptor-related protein

Expression of nephrin in acquired forms of nephrotic syndrome in childhood

Exogenous bone morphogenetic protein-7 fails to attenuate renal fibrosis in rats with overload proteinuria

The NPHP1 gene deletion associated with juvenile nephronophthisis is present in a subset of individuals with Joubert syndrome