BCCHR Researchers Find a Researcher

Amy Lee

BSc, MSc, PhD

Investigator, BC Children's Hospital

Infectious diseases are 3 of the top 10 leading causes of death globally. In low-income countries, communicable diseases cause more than half of all deaths, especially among vulnerable newborns. In high-income countries such as Canada, infections account for 2-7% of deaths. Bacterial infections are often treatable using antibiotics, but chronic misuse of antibiotics has created a critical global health threat by increasing the presence of antimicrobial resistant organisms, thus further compounding the problem. Given that communicable diseases cause significant personal, societal and economic burdens worldwide, the United Nations highlighted the importance to "accelerate the pace of progress made in fighting … communicable diseases and epidemics, including by addressing growing antimicrobial resistance" in its Sustainable Development Goals.

Our group is interested in applying systems biology approaches to untangle the dynamic interactions between antimicrobial resistant pathogens and the host by:

1. Understanding host immune responses during infection, focusing on the critical area of neonatal sepsis

2. Characterizing how bacterial pathogens can maintain or disseminate antimicrobial resistant genes in diverse environments

3. Identifying novel virulence or antimicrobial resistance genes in these bacterial pathogens

Academic Affiliations

Assistant Professor, , Department of Molecular Biology and Biochemistry, Faculty of Science, Simon Fraser University
Research Theme: Healthy Starts
Research Group(s): Global Health and Innovations; Origins of Child Health and Disease; Vaccines, Infections, and Host Defenses

Contact Information

Location

Simon Fraser University, #7107, South Sciences Building, 8888 University Dr., Burnaby, British Columbia, Canada, V5A 1S6

amy_lee_10@sfu.ca

Lee Lab

A plasma protein biomarker signature that differentiates acute rheumatic fever from related clinical presentations

Research Square

Carapetis, J. and Okello, E. and Barnett, T. and Shannon, C. and Atala, J. and Brinkman, R. and Broadhurst, D. and Drouart, G. and Everest, C. and Kresoje, N. and Lee, A. and Lwabi, P. and Montante, S. and Martino, D. and Ndagire, E. and Oyella, L. and Othman, R.B. and Pulle, J. and Sable, C. and Sarnacki, R. and Serralha, M. and Tebbutt, S. and Beaton, A. and Kollmann, T. and Lee, W.

DOI: 10.21203/rs.3.rs-4345781/v1

Time-course transcriptomics reveals the impact of Treponema pallidum on microvascular endothelial cell function and phenotype

Frontiers in Microbiology

Waugh, S. and Goodyear, M.C. and Gomez, A. and Ranasinghe, A. and Lithgow, K.V. and Falsafi, R. and Hancock, R.E.W. and Lee, A.H. and Cameron, C.E.

DOI: 10.3389/fmicb.2025.1649738

From Local to Systemic: The Journey of Tick Bite Biomarkers in Australian Patients

International Journal of Molecular Sciences

Lee, W. and Barbosa, A.D. and Lee, A.H.-Y. and Currie, A. and Martino, D. and Stenos, J. and Long, M. and Beaman, M. and Harvey, N.T. and Kresoje, N. and Skut, P. and Irwin, P.J. and Kumarasinghe, P. and Hall, R.A. and Ben-Othman, R. and Graves, S. and Kollmann, T.R. and Oskam, C.L.

DOI: 10.3390/ijms26041520

Molecular analysis of human tick-bitten skin yields signatures associated with distinct spatial and temporal trajectories - A proof-of-concept study

Heliyon

Lee, W. and Ben-Othman, R. and Skut, P. and Lee, A.H.-Y. and Barbosa, A.D. and Beaman, M. and Currie, A. and Harvey, N.T. and Kumarasinghe, P. and Hall, R.A. and Potter, J. and Graves, S. and West, N.P. and Cox, A.J. and Irwin, P.J. and Kollmann, T.R. and Oskam, C.L.

DOI: 10.1016/j.heliyon.2024.e33600

Pseudomonas aeruginosa in chronic lung disease: untangling the dysregulated host immune response

Frontiers in Immunology

Nickerson, R. and Thornton, C.S. and Johnston, B. and Lee, A.H.Y. and Cheng, Z.

DOI: 10.3389/fimmu.2024.1405376

Factors associated with SARS-CoV-2 infection in unvaccinated children and young adults

BMC Infectious Diseases

Silverberg, S.L. and Shulha, H.P. and McMillan, B. and He, G. and Lee, A. and Mrquez, A.C. and Bartlett, S.R. and Gill, V. and Abu-Raya, B. and Bettinger, J.A. and Cabrera, A. and Coombs, D. and Gantt, S. and Goldfarb, D.M. and Sauv, L. and Krajden, M. and Morshed, M. and Sekirov, I. and Jassem, A.N. and Sadarangani, M.

DOI: 10.1186/s12879-023-08950-1

DNA Methylation signatures underpinning blood neutrophil to lymphocyte ratio during first week of human life

Nature Communications

Martino, D. and Kresoje, N. and Amenyogbe, N. and Ben-Othman, R. and Cai, B. and Lo, M. and Idoko, O. and Odumade, O.A. and Falsafi, R. and Blimkie, T.M. and An, A. and Shannon, C.P. and Montante, S. and Dhillon, B.K. and Diray-Arce, J. and Ozonoff, A. and Smolen, K.K. and Brinkman, R.R. and McEnaney, K. and Angelidou, A. and Richmond, P. and Tebbutt, S.J. and Kampmann, B. and Levy, O. and Hancock, R.E.W. and Lee, A.H.Y. and Kollmann, T.R.

DOI: 10.1038/s41467-024-52283-9

Breastfeeding and Neonatal Age Influence Neutrophil-Driven Ontogeny of Blood Cell Populations in the First Week of Human Life

Journal of Immunology Research

Montante, S. and Ben-Othman, R. and Amenyogbe, N. and Angelidou, A. and Van Den Biggelaar, A. and Cai, B. and Chen, Y. and Darboe, A. and Diray-Arce, J. and Ford, R. and Idoko, O. and Lee, A. and Lo, M. and McEnaney, K. and Malek, M. and Martino, D. and Masiria, G. and Odumade, O.A. and Pomat, W. and Shannon, C. and Smolen, K. and Consortium, T.E. and Ozonoff, A. and Richmond, P. and Tebbutt, S. and Levy, O. and Kampmann, B. and Brinkman, R. and Kollmann, T.

DOI: 10.1155/2024/1117796

Concentration-dependent alterations in the human plasma proteome following controlled exposure to diesel exhaust

Environmental Pollution

Orach, J. and Hemshekhar, M. and Rider, C.F. and Spicer, V. and Lee, A.H. and Yuen, A.C.Y. and Mookherjee, N. and Carlsten, C.

DOI: 10.1016/j.envpol.2023.123087

Predictive gene expression signature diagnoses neonatal sepsis before clinical presentation

Ebiomedicine

An, A.Y. and Acton, E. and Idoko, O.T. and Shannon, C.P. and Blimkie, T.M. and Falsafi, R. and Wariri, O. and Imam, A. and Dibbasey, T. and Bennike, T.B. and Smolen, K.K. and Diray-Arce, J. and Ben-Othman, R. and Montante, S. and Angelidou, A. and Odumade, O.A. and Martino, D. and Tebbutt, S.J. and Levy, O. and Steen, H. and Kollmann, T.R. and Kampmann, B. and Hancock, R.E.W. and Lee, A.H. and Amenyogbe, N. and Bao, W. and Bjerregaard-Andersen, M. and Brinkman, R.R. and Brook, B. and Burnell, K. and Cai, B. and Checkervarty, A. and Chen, J. and Chen, V. and Cooney, M. and Cox, M. and Darboe, A. and Dhillon, B.K. and Dibassey, T. and Fatou, B. and Ford, R. and Francis, F. and Golding, C.N. and Harbeson, D.J. and He, D. and Hinshaw, S.H. and Hoch, A. and Huang, J. and Kirarock, W. and Karoly, M.E. and Kraft, K. and Larsen, K. and Lasky-Su, J. and Liu, A. and A and Liu, M. and M and Malek, M. and Marchant, A. and Masiria, G. and Matlam, J.P. and McEnaney, K. and McLoughlin, C. and Morrocchi, E. and Ndure, J. and Nguyen, A. and Njie-Jobe, J. and Ozonoff, A. and Pak, J. and Palma, P. and Parker, E.P.K. and Pettengill, M.A. and Plotkin, A. and Pomat, W.S. and Rao, S. and Richmond, P.C. and Roberts, E. and Saleu, G. and Sanca, L. and Sanchez-Schmitz, G. and Schaltz-Buchholzer, F. and Singh, A. and Smith, M. and Strandmark, J. and Syphurs, C. and van den Biggelaar, A.H.J. and van Haren, S.D. and Varankovich, N. and Vignolo, S. and Vo, D.

DOI: 10.1016/j.ebiom.2024.105411

Gene Expression Profiling in Pediatric Appendicitis

JAMA Pediatrics

Dhillon, B.K. and Kortbeek, S. and Baghela, A. and Brindle, M. and Martin, D.-A. and Jenne, C.N. and Vogel, H.J. and Lee, A.H.Y. and Thompson, G.C. and Hancock, R.E.W.

DOI: 10.1001/jamapediatrics.2023.6721

Angiogenesis-associated pathways play critical roles in neonatal sepsis outcomes

Scientific Reports

Fidanza, M. and Hibbert, J. and Acton, E. and Harbeson, D. and Schoeman, E. and Skut, P. and Woodman, T. and Eynaud, A. and Hartnell, L. and Brook, B. and Cai, B. and Lo, M. and Falsafi, R. and Hancock, R.E.W. and Chiume-Kayuni, M. and Lufesi, N. and Popescu, C.R. and Lavoie, P.M. and Strunk, T. and Currie, A.J. and Kollmann, T.R. and Amenyogbe, N. and Lee, A.H.

DOI: 10.1038/s41598-024-62195-9

A Commentary on Multi-omics Data Integration in Systems Vaccinology

Journal of Molecular Biology

Shannon, C.P. and Lee, A.H. and Tebbutt, S.J. and Singh, A.

DOI: 10.1016/j.jmb.2024.168522

The role of engineered materials in mucosal vaccination strategies

Nature Reviews Materials

Eshaghi, B. and Schudel, A. and Sadeghi, I. and Chen, Z. and Lee, A.H. and Kanelli, M. and Tierney, F. and Han, J. and Ingalls, B. and Francis, D.M. and Li, G. and von Andrian, U. and Langer, R. and Jaklenec, A.

DOI: 10.1038/s41578-023-00625-2

Pathogen-associated gene discovery workflows for novel antivirulence therapeutic development

eBioMedicine

Wing Yin Venus Lau and Patrick K. Taylor and Fiona S.L. Brinkman and Amy H.Y. Lee

DOI: 10.1016/j.ebiom.2022.104429

02 / 2023

A systems biology approach to better understand human tick-borne diseases

Trends in Parasitology

Wenna Lee and Amanda D. Barbosa and Peter J. Irwin and Andrew Currie and Tobias R. Kollmann and Miles Beaman and Amy H. Lee and Charlotte L. Oskam

DOI: 10.1016/j.pt.2022.10.006

01 / 2023

Persistence is key: unresolved immune dysfunction is lethal in both COVID-19 and non-COVID-19 sepsis

Frontiers in Immunology

An, A.Y. and Baghela, A. and Zhang, P. and Falsafi, R. and Lee, A.H. and Trahtemberg, U. and Baker, A.J. and Santos, C.C.D. and Hancock, R.E.W.

DOI: 10.3389/fimmu.2023.1254873

Severe COVID-19 and non-COVID-19 severe sepsis converge transcriptionally after a week in the intensive care unit, indicating common disease mechanisms

Frontiers in Immunology

An, A.Y. and Baghela, A. and Zhang, P. and Falsafi, R. and Lee, A.H. and Trahtemberg, U. and Baker, A.J. and dos Santos, C.C. and Hancock, R.E.W.

DOI: 10.3389/fimmu.2023.1167917

Predicting severity in COVID-19 disease using sepsis blood gene expression signatures

Scientific Reports

Baghela, A. and An, A. and Zhang, P. and Acton, E. and Gauthier, J. and Brunet-Ratnasingham, E. and Blimkie, T. and Freue, G.C. and Kaufmann, D. and Lee, A.H.Y. and Levesque, R.C. and Hancock, R.E.W.

DOI: 10.1038/s41598-023-28259-y

Post-COVID symptoms are associated with endotypes reflecting poor inflammatory and hemostatic modulation

Frontiers in Immunology

An, A.Y. and Baghela, A. and Zhang, P.G.Y. and Blimkie, T.M. and Gauthier, J. and Kaufmann, D.E. and Acton, E. and Lee, A.H.Y. and Levesque, R.C. and Hancock, R.E.W.

DOI: 10.3389/fimmu.2023.1243689

Validation of reference gene stability for miRNA quantification by reverse transcription quantitative PCR in the peripheral blood of patients with COVID-19 critical illness

PLoS ONE

Formosa, A. and Acton, E. and Lee, A. and Turgeon, P. and Izhar, S. and Plant, P. and Tsoporis, J.N. and Soussi, S. and Trahtemberg, U. and Baker, A. and dos Santos, C.C.

DOI: 10.1371/journal.pone.0286871

Factors associated with severe acute respiratory syndrome-related coronavirus 2 infection in unvaccinated children and young adults

medRxiv

Silverberg, S.L. and Shulha, H.P. and McMillan, B. and He, G. and Lee, A. and Mrquez, C. and Bartlett, S.R. and Gill, V. and Abu-Raya, B. and Bettinger, J.A. and Cabrera, A. and Coombs, D. and Gantt, S. and Goldfarb, D.M. and Sauv, L. and Krajden, M. and Morshed, M. and Sekirov, I. and Jassem, A.N. and Sadarangani, M.

DOI: 10.1101/2023.08.13.23294036

Dynamic gene expression analysis reveals distinct severity phases of immune and cellular dysregulation in COVID-19

Biorxiv

An, A.Y. and Baghela, A. and Zhang, P. and Blimkie, T.M. and Gauthier, J. and Kaufmann, D.E. and Acton, E. and Lee, A.H.Y. and Levesque, R.C. and Hancock, R.E.W.

DOI: 10.1101/2023.11.04.565404

Gut microbes shape microglia and cognitive function during malnutrition

GLIA

Bauer, K.C. and York, E.M. and Cirstea, M.S. and Radisavljevic, N. and Petersen, C. and Huus, K.E. and Brown, E.M. and Bozorgmehr, T. and Berd{\'u}n, R. and Bernier, L.-P. and Lee, A.H.Y. and Woodward, S.E. and Krekhno, Z. and Han, J. and Hancock, R.E.W. and Ayala, V. and MacVicar, B.A. and Finlay, B.B.

DOI: 10.1002/glia.24139

BosR: A novel biofilm-specific regulator in Pseudomonas aeruginosa

Frontiers in Microbiology

Dostert, M. and Belanger, C.R. and Pedraz, L. and Alford, M.A. and Blimkie, T.M. and Falsafi, R.F. and Bains, M. and Dhillon, B.K. and Haney, C.H. and Lee, A.H. and Hancock, R.E.W.

DOI: 10.3389/fmicb.2022.1021021

Surviving the host: Microbial metabolic genes required for growth of Pseudomonas aeruginosa in physiologically-relevant conditions

Frontiers in Microbiology

Belanger, C.R. and Dostert, M. and Blimkie, T.M. and Lee, A.H.-Y. and Dhillon, B.K. and Wu, B.C. and Akhoundsadegh, N. and Rahanjam, N. and Castillo-Arnemann, J. and Falsafi, R. and Pletzer, D. and Haney, C.H. and Hancock, R.E.W.

DOI: 10.3389/fmicb.2022.1055512

Salt and surfactant coated filters with antiviral properties and low pressure drop for prospective SARS-CoV2 applications

Scientific Reports

Ebadi, M. and McCague, C. and Vallee, O. and Taylor, P.K. and Lee, A.H.Y. and Bahrami, M.

DOI: 10.1038/s41598-022-15203-9

Predicting sepsis severity at first clinical presentation: The role of endotypes and mechanistic signatures

eBioMedicine

Baghela, A. and Pena, O.M. and Lee, A.H. and Baquir, B. and Falsafi, R. and An, A. and Farmer, S.W. and Hurlburt, A. and Mondragon-Cardona, A. and Rivera, J.D. and Baker, A. and Trahtemberg, U. and Shojaei, M. and Jimenez-Canizales, C.E. and dos Santos, C.C. and Tang, B. and Bouma, H.R. and Cohen Freue, G.V. and Hancock, R.E.W.

DOI: 10.1016/j.ebiom.2021.103776

A transcriptomic analysis of the effects of macrophage polarization and endotoxin tolerance on the response to Salmonella

PLoS ONE

Sedivy-Haley, K. and Blimkie, T. and Falsafi, R. and Lee, A.H.-Y. and Hancock, R.E.W.

DOI: 10.1371/journal.pone.0276010

Genomic insights into the diversity, virulence and resistance of Klebsiella pneumoniae extensively drug resistant clinical isolates

Microbial Genomics

Amy H. Y Lee and William F. Porto and Clio de Faria Jr and Simoni C. Dias and Srgio A. Alencar and Derek J. Pickard and Robert E. W. Hancock and Octavio L. Franco

DOI: 10.1099/mgen.0.000613

08 / 2021

Different Disease Endotypes in Phenotypically Similar Vasculitides Affecting Small-to-Medium Sized Blood Vessels

Frontiers in Immunology

Gill, E.E. and Smith, M.L. and Gibson, K.M. and Morishita, K.A. and Lee, A.H.Y. and Falsafi, R. and Graham, J. and Foell, D. and Benseler, S.M. and Ross, C.J. and Luqmani, R.A. and Cabral, D.A. and Hancock, R.E.W. and Brown, K.L.

DOI: 10.3389/fimmu.2021.638571

Peptide 1018 inhibits swarming and influences Anr-regulated gene expression downstream of the stringent stress response in Pseudomonas aeruginosa

PLoS ONE

Wilkinson, L.V. and Alford, M.A. and Coleman, S.R. and Wu, B.C. and Lee, A.H.Y. and Blimkie, T.M. and Bains, M. and Falsafi, R. and Pletzer, D. and Hancock, R.E.W.

DOI: 10.1371/journal.pone.0250977

Machine Learning-Based Single Cell and Integrative Analysis Reveals That Baseline mDC Predisposition Correlates With Hepatitis B Vaccine Antibody Response

Frontiers in Immunology

Aevermann, B.D. and Shannon, C.P. and Novotny, M. and Ben-Othman, R. and Cai, B. and Zhang, Y. and Ye, J.C. and Kobor, M.S. and Gladish, N. and Lee, A.H.-Y. and Blimkie, T.M. and Hancock, R.E. and Llibre, A. and Duffy, D. and Koff, W.C. and Sadarangani, M. and Tebbutt, S.J. and Kollmann, T.R. and Scheuermann, R.H.

DOI: 10.3389/fimmu.2021.690470

RNase III and RNase E Influence Posttranscriptional Regulatory Networks Involved in Virulence Factor Production, Metabolism, and Regulatory RNA Processing in Bordetella pertussis

mSphere

Ifill, G. and Blimkie, T. and Lee, A.H.-Y. and Mackie, G.A. and Chen, Q. and Stibitz, S. and Hancock, R.E.W. and Fernandez, R.C.

DOI: 10.1128/mSphere.00650-21

Machine learning-based single cell and integrative analysis reveals that baseline mDC predisposition predicts protective Hepatitis B vaccine response

medRxiv

Aevermann, B. and Shannon, C.P. and Novotny, M. and Ben-Othman, R. and Cai, B. and Zhang, Y. and Ye, J.C. and Kobor, M.S. and Gladish, N. and Lee, A. and Blimke, T.M. and Hancock, R.E. and Llibre, A. and Duffy, D. and Koff, W.C. and Sadarangani, M. and Tebbutt, S.J. and Kollmann, T.R. and Scheuermann, R.H.

DOI: 10.1101/2021.02.22.21251864

Human-induced pluripotent stem cell-derived macrophages for studying infection biology and immunology

Current Progress in iPSC-derived Cell Types

Baquir, B. and An, A.Y. and Lee, A.H.Y. and Hancock, R.E.W.

DOI: 10.1016/B978-0-12-823884-4.00002-X

Identification of novel targets of azithromycin activity against Pseudomonas aeruginosa grown in physiologically relevant media

Proceedings of the National Academy of Sciences

Corrie R. Belanger and Amy Huei-Yi Lee and Daniel Pletzer and Bhavjinder Kaur Dhillon and Reza Falsafi and Robert E. W. Hancock

DOI: 10.1073/pnas.2007626117

12 / 2020

Whole blood genome-wide transcriptome profiling and metagenomics next-generation sequencing in young infants with suspected sepsis in a low-and middle-income country: A study protocol

Gates Open Research

Constantin R. Popescu and Bentry Tembo and Rhoda Chifisi and Miranda M.M. Cavanagh and Amy Huei-Yi Lee and Blessings Chiluzi and Emily J. Ciccone and Gerald Tegha and Esther Alonso-Prieto and Jennifer Claydon and Dustin Dunsmuir and Mike Irvine and Guy Dumont and J. Mark Ansermino and Matthew O. Wiens and Jonathan J. Juliano and Niranjan Kissoon and Tisungane Mvalo and Norman Lufesi and Msandeni Chiume-Kayuni and Pascal M. Lavoie

DOI: 10.12688/gatesopenres.13172.2

11 / 2020

Aberrant cell migration contributes to defective airway epithelial repair in childhood wheeze

JCI Insight

Thomas Iosifidis and Erika N. Sutanto and Alysia G. Buckley and Laura Coleman and Erin E. Gill and Amy H. Lee and Kak-Ming Ling and Jessica Hillas and Kevin Looi and Luke W. Garratt and Kelly M. Martinovich and Nicole C. Shaw and Samuel T. Montgomery and Elizabeth Kicic-Starcevich and Yuliya V. Karpievitch and Peter Le Souf and Ingrid A. Laing and Shyan Vijayasekaran and Francis J. Lannigan and Paul J. Rigby and Robert E.W. Hancock and Darryl A. Knight and Stephen M. Stick and Anthony Kicic.

DOI: 10.1172/jci.insight.133125

04 / 2020

Systems Biology Approaches to Understanding the Human Immune System

Frontiers in Immunology

Dhillon, B.K. and Smith, M. and Baghela, A. and Lee, A.H.Y. and Hancock, R.E.W.

DOI: 10.3389/fimmu.2020.01683

Systems Biology Methods Applied to Blood and Tissue for a Comprehensive Analysis of Immune Response to Hepatitis B Vaccine in Adults

Frontiers in immunology

Ben-Othman, Rym and Cai, Bing and Liu, Aaron C and Varankovich, Natallia and He, Daniel and Blimkie, Travis M and Lee, Amy H and Gill, Erin E and Novotny, Mark and Aevermann, Brian and Drissler, Sibyl and Shannon, Casey P and McCann, Sarah and Marty, Kim and Bjornson, Gordean and Edgar, Rachel D and Lin, David Tse Shen and Gladish, Nicole and Maclsaac, Julia and Amenyogbe, Nelly and Chan, Queenie and Llibre, Alba and Collin, Joyce and Landais, Elise and Le, Khoa and Reiss, Samantha M and Koff, Wayne C and Havenar-Daughton, Colin and Heran, Manraj and Sangha, Bippan and Walt, David and Krajden, Mel and Crotty, Shane and Sok, Devin and Briney, Bryan and Burton, Dennis R and Duffy, Darragh and Foster, Leonard J and Mohn, William W and Kobor, Michael S and Tebbutt, Scott J and Brinkman, Ryan R and Scheuermann, Richard H and Hancock, Robert E W and Kollmann, Tobias R and Sadarangani, Manish

DOI: 10.3389/fimmu.2020.580373

Utilizing Organoid and Air-Liquid Interface Models as a Screening Method in the Development of New Host Defense Peptides

Frontiers in cellular and infection microbiology

Choi, Ka-Yee Grace and Wu, Bing Catherine and Lee, Amy Huei-Yi and Baquir, Beverlie and Hancock, Robert E W

DOI: 10.3389/fcimb.2020.00228

Preparing for Life: Plasma Proteome Changes and Immune System Development During the First Week of Human Life

Frontiers in immunology

Bennike, Tue Bjerg and Fatou, Benoit and Angelidou, Asimenia and Diray-Arce, Joann and Falsafi, Reza and Ford, Rebecca and Gill, Erin E and van Haren, Simon D and Idoko, Olubukola T and Lee, Amy H and Ben-Othman, Rym and Pomat, William S and Shannon, Casey P and Smolen, Kinga K and Tebbutt, Scott J and Ozonoff, Al and Richmond, Peter C and van den Biggelaar, Anita H J and Hancock, Robert E W and Kampmann, Beate and Kollmann, Tobias R and Levy, Ofer and Steen, Hanno

DOI: 10.3389/fimmu.2020.578505

Ivacaftor or lumacaftor/ivacaftor treatment does not alter the core CF airway epithelial gene response to rhinovirus

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

De Jong, Emma and Garratt, Luke W and Looi, Kevin and Lee, Amy H Y and Ling, Kak-Ming and Smith, Maren L and Falsafi, Reza and Sutanto, Erika N and Hillas, Jessica and Iosifidis, Thomas and Martinovich, Kelly M and Shaw, Nicole C and Montgomery, Samuel T and Kicic-Starcevich, Elizabeth and Lannigan, Francis J and Vijayasekaran, Shyan and Hancock, Robert E W and Stick, Stephen M and Kicic, Anthony and {WAERP} and Arest, CF

DOI: 10.1016/j.jcf.2020.07.004

The importance of reporting house dust mite endotoxin abundance: Impact on the lung transcriptome

American Journal of Physiology - Lung Cellular and Molecular Physiology

Pascoe, C.D. and Jha, A. and Basu, S. and Mahood, T. and Lee, A. and Hinshaw, S. and Falsafi, R. and Hancock, R.E.W. and Mookherjee, N. and Halayko, A.J.

DOI: 10.1152/ajplung.00103.2020

Regional Dichotomy in Enteric Mucosal Immune Responses to a Persistent Mycobacterium avium ssp. paratuberculosis Infection

Frontiers in immunology

Facciuolo, Antonio and Lee, Amy H and Gonzalez Cano, Patricia and Townsend, Hugh G G and Falsafi, Reza and Gerdts, Volker and Potter, Andrew and Napper, Scott and Hancock, REW and Mutharia, Lucy M and Griebel, Philip J

DOI: 10.3389/fimmu.2020.01020

Multi-Omic Data Integration Allows Baseline Immune Signatures to Predict Hepatitis B Vaccine Response in a Small Cohort

Frontiers in immunology

Shannon, Casey P and Blimkie, Travis M and Ben-Othman, Rym and Gladish, Nicole and Amenyogbe, Nelly and Drissler, Sibyl and Edgar, Rachel D and Chan, Queenie and Krajden, Mel and Foster, Leonard J and Kobor, Michael S and Mohn, William W and Brinkman, Ryan R and Le Cao, Kim-Anh and Scheuermann, Richard H and Tebbutt, Scott J and Hancock, Robert E W and Koff, Wayne C and Kollmann, Tobias R and Sadarangani, Manish and Lee, Amy Huei-Yi

DOI: 10.3389/fimmu.2020.578801

MetaBridge: An Integrative Multi-Omics Tool for Metabolite-Enzyme Mapping

Current protocols in bioinformatics

Blimkie, Travis and Lee, Amy Huei-Yi and Hancock, Robert E W

DOI: 10.1002/cpbi.98

BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis

Science translational medicine

Brook, Byron and Harbeson, Danny J and Shannon, Casey P and Cai, Bing and He, Daniel and Ben-Othman, Rym and Francis, Freddy and Huang, Joe and Varankovich, Natallia and Liu, Aaron and Bao, Winnie and Bjerregaard-Andersen, Morten and Schaltz-Buchholzer, Frederik and Sanca, Lilica and Golding, Christian N and Larsen, Kristina Lindberg and Levy, Ofer and Kampmann, Beate and {EPIC Consortium} and Tan, Rusung and Charles, Adrian and Wynn, James L and Shann, Frank and Aaby, Peter and Benn, Christine S and Tebbutt, Scott J and Kollmann, Tobias R and Amenyogbe, Nelly

DOI: 10.1126/scitranslmed.aax4517

A Bovine Enteric Mycobacterium Infection Model to Analyze Parenteral Vaccine-Induced Mucosal Immunity and Accelerate Vaccine Discovery

Frontiers in immunology

Facciuolo, Antonio and Lee, Amy H and Trimble, Michael J and Rawlyk, Neil and Townsend, Hugh G G and Bains, Manjeet and Arsic, Natasa and Mutharia, Lucy M and Potter, Andrew and Gerdts, Volker and Napper, Scott and Hancock, Robert E W and Griebel, Philip J

DOI: 10.3389/fimmu.2020.586659

Whole blood transcriptional responses of very preterm infants during late-onset sepsis

PloS one

Ng, Sherrianne and Strunk, Tobias and Lee, Amy H and Gill, Erin E and Falsafi, Reza and Woodman, Tabitha and Hibbert, Julie and Hancock, Robert E W and Currie, Andrew

DOI: 10.1371/journal.pone.0233841

Rhinovirus Infection Drives Complex Host Airway Molecular Responses in Children With Cystic Fibrosis

Frontiers in immunology

Ling, Kak-Ming and Garratt, Luke W and Gill, Erin E and Lee, Amy H Y and Agudelo-Romero, Patricia and Sutanto, Erika N and Iosifidis, Thomas and Rosenow, Tim and Turvey, Stuart E and Lassmann, Timo and Hancock, Robert E W and Kicic, Anthony and Stick, Stephen M

DOI: 10.3389/fimmu.2020.01327

The Stringent Stress Response Controls Proteases and Global Regulators under Optimal Growth Conditions in Pseudomonas aeruginosa

mSystems

Pletzer, Daniel and Blimkie, Travis M and Wolfmeier, Heidi and Li, Yicong and Baghela, Arjun and Lee, Amy H Y and Falsafi, Reza and Hancock, Robert E W

DOI: 10.1128/mSystems.00495-20

Characterization of immune responses and the lung transcriptome in a murine model of IL-33 challenge

Biochimica et biophysica acta. Molecular basis of disease

Piyadasa, Hadeesha and Lloyd, Dylan and Lee, Amy H Y and Altieri, Anthony and Hemshekhar, Mahadevappa and Osawa, Natasha and Basu, Sujata and Blimkie, Travis and Falsafi, Reza and Halayko, Andrew J and Hancock, Robert E W and Mookherjee, Neeloffer

DOI: 10.1016/j.bbadis.2020.165950

Perturbations of the ZED1 pseudokinase activate plant immunity

PLOS Pathogens

DOI: 10.1371/journal.ppat.1007900

07 / 2019

Identifying Pseudomonas syringae Type III Secreted Effector Function via a Yeast Genomic Screen.

G3 (Bethesda, Md.)

DOI: 10.1534/g3.118.200877 PubMed: 30573466

02 / 2019

Dynamic molecular changes during the first week of human life follow a robust developmental trajectory

Nature communications

Lee, Amy H and Shannon, Casey P and Amenyogbe, Nelly and Bennike, Tue B and Diray-Arce, Joann and Idoko, Olubukola T and Gill, Erin E and Ben-Othman, Rym and Pomat, William S and van Haren, Simon D and Cao, Kim-Anh L and Cox, Momoudou and Darboe, Alansana and Falsafi, Reza and Ferrari, Davide and Harbeson, Daniel J and He, Daniel and Bing, Cai and Hinshaw, Samuel J and Ndure, Jorjoh and Njie-Jobe, Jainaba and Pettengill, Matthew A and Richmond, Peter C and Ford, Rebecca and Saleu, Gerard and Masiria, Geraldine and Matlam, John Paul and Kirarock, Wendy and Roberts, Elishia and Malek, Mehrnoush and Sanchez-Schmitz, Guzmn and Singh, Amrit and Angelidou, Asimenia and Smolen, Kinga K and {EPIC Consortium} and Brinkman, Ryan R and Ozonoff, Al and Hancock, Robert E W and van den Biggelaar, Anita H J and Steen, Hanno and Tebbutt, Scott J and Kampmann, Beate and Levy, Ofer and Kollmann, Tobias R

DOI: 10.1038/s41467-019-08794-x

Characterization of Host Responses during Pseudomonas aeruginosa Acute Infection in the Lungs and Blood and after Treatment with the Synthetic Immunomodulatory Peptide IDR-1002

Infection and immunity

Wuerth, Kelli and Lee, Amy H Y and Falsafi, Reza and Gill, Erin E and Hancock, Robert E W

DOI: 10.1128/iai.00661-18

A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection

mBio

Yeung, Amy T Y and Choi, Yoon Ha and Lee, Amy H Y and Hale, Christine and Ponstingl, Hannes and Pickard, Derek and Goulding, David and Thomas, Mark and Gill, Erin and Kim, Jong Kyoung and Bradley, Allan and Hancock, Robert E W and Dougan, Gordon

DOI: 10.1128/mbio.02169-19

Yeast Genomic Screens Identify Kinesins as Potential Targets of the Pseudomonas syringae Type III Effector, HopZ1a

Lee AH and Bastedo DP and Lo T and Middleton MA and Youn J and Kireeva I and Lee JY and Sharifpoor S and Baryshnikova A and Zhang J and Wang PW and Peisajovich SG and Costanzo M and Guttman DS

DOI: 10.1101/365692

07 / 2018

Retinoic acid elicits a coordinated expression of gut homing markers on T lymphocytes of Zambian men receiving oral Vivotif, but not Rotarix, Dukoral or OPVERO vaccines.

Vaccine

Mwanza-Lisulo M and Chomba MS and Chama M and Besa EC and Funjika E and Zyambo K and Banda R and Imikendu M and Sianongo S and Hancock REW and Lee A and Chilengi R and Stagg AJ and Kelly PM

DOI: 10.1016/j.vaccine.2018.04.083 PubMed: 29801999

05 / 2018

MetaBridge: enabling network-based integrative analysis via direct protein interactors of metabolites

Bioinformatics (Oxford, England)

Hinshaw, Samuel J and Lee, Amy H Y and Gill, Erin E and Hancock, Robert E W

DOI: 10.1093/bioinformatics/bty331

Comparative functional genomic screens of three yeast deletion collections reveal unexpected effects of genotype in response to diverse stress.

Open biology

DOI: 10.1098/rsob.160330 PubMed: 28592509

06 / 2017

Phenotypic diversity and genotypic flexibility of Burkholderia cenocepacia during long-term chronic infection of cystic fibrosis lungs.

Genome research

DOI: 10.1101/gr.213363.116 PubMed: 28325850

04 / 2017

Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis.

Nature communications

DOI: 10.1038/ncomms15013 PubMed: 28440293

04 / 2017

hackseq: Catalyzing collaboration between biological and computational scientists via hackathon.

F1000Research

hackseq Organizing Committee 2016

DOI: 10.12688/f1000research.10964.2 PubMed: 28417000

02 / 2017

Mechanisms of the Innate Defense Regulator Peptide-1002 Anti-Inflammatory Activity in a Sterile Inflammation Mouse Model

Journal of immunology (Baltimore, Md. : 1950)

Wu, Bing Catherine and Lee, Amy Huei-Yi and Hancock, Robert E W

DOI: 10.4049/jimmunol.1700985

Functional Genomics Using the Saccharomyces cerevisiae Yeast Deletion Collections.

Nislow C and Wong LH and Lee AH and Giaever G

DOI: 10.1101/pdb.top080945 PubMed: 27587784

Functional Profiling Using the Saccharomyces Genome Deletion Project Collections.

Nislow C and Wong LH and Lee AH and Giaever G

DOI: 10.1101/pdb.prot088039 PubMed: 27587776

The Arabidopsis ZED1 pseudokinase is required for ZAR1-mediated immunity induced by the Pseudomonas syringae type III effector HopZ1a.

Lewis JD and Lee AH and Hassan JA and Wan J and Hurley B and Jhingree JR and Wang PW and Lo T and Youn JY and Guttman DS and Desveaux D

DOI: 10.1073/pnas.1315520110 PubMed: 24170858

11 / 2013

Phytopathogen type III effectors as probes of biological systems.

Lee AH and Middleton MA and Guttman DS and Desveaux D

DOI: 10.1111/1751-7915.12042 PubMed: 23433088

05 / 2013

Effector wisdom.

Lee AH and Petre B and Joly DL

DOI: 10.1111/nph.12058 PubMed: 23253332

01 / 2013

A bacterial acetyltransferase destroys plant microtubule networks and blocks secretion.

Lee AH and Hurley B and Felsensteiner C and Yea C and Ckurshumova W and Bartetzko V and Wang PW and Quach V and Lewis JD and Liu YC and Brnke F and Angers S and Wilde A and Guttman DS and Desveaux D

DOI: 10.1371/journal.ppat.1002523 PubMed: 22319451

02 / 2012

The YopJ superfamily in plant-associated bacteria.

Lewis JD and Lee A and Ma W and Zhou H and Guttman DS and Desveaux D

DOI: 10.1111/j.1364-3703.2011.00719.x PubMed: 21726386

12 / 2011

ClpX inhibits FtsZ assembly in a manner that does not require its ATP hydrolysis-dependent chaperone activity.

Haeusser DP and Lee AH and Weart RB and Levin PA

DOI: 10.1128/jb.01606-07 PubMed: 19136590

03 / 2009

A metabolic sensor governing cell size in bacteria.

Weart RB and Lee AH and Chien AC and Haeusser DP and Hill NS and Levin PA

DOI: 10.1016/j.cell.2007.05.043 PubMed: 17662947

07 / 2007

Urea sensitization caused by separation of Helicobacter pylori RNA polymerase beta and beta' subunits.

Dailidiene D and Tan S and Ogura K and Zhang M and Lee AH and Severinov K and Berg DE

DOI: 10.1111/j.1523-5378.2007.00479.x PubMed: 17309746

04 / 2007

Genes controlling circadian rhythm are widely distributed in cyanobacteria

FEMS Microbiology Letters

Lorne, J. and Scheffer, J. and Lee, A. and Painter, M. and Miao, V.P.W.

DOI: 10.1016/S0378-1097(00)00237-8

Cultural and molecular characterization of photobionts of Peltigera membranacea

Lichenologist

Miao, V.P.W. and Rabenau, A. and Lee, A.

DOI: 10.1006/lich.1997.0114

Neonatal Immune Development

Infection is the most common cause of death in newborns, causing at least 2.6 million infant deaths per year. Even though the majority of newborn deaths occur in resource-poor countries, neonatal morbidity and mortality is also a significant problem in resource-rich countries. For instance, in Canada, 75% of infant deaths under 1 year occur during this critical newborn stage. Our group is working to understand why newborns are so prone to infections and the pathogens at play, so that we can develop effective interventions and preventions against diseases. Our previous work demonstrates that newborn immunity, rather than being simply immature as previously thought, actually follow an exquisite, consistent and detailed developmental trajectory that most likely reflects adaptation to the demands of early life. We are currently working on using multi-omics data (transcriptomics, epigenomics, proteomics, metabolomics and microbiome) to extend and build an integrated molecular profile of a neonatal immune system during the first week of life.

Neonatal Sepsis

Each second, five newborn babies die from suspected life-threatening infections somewhere in the world. Newborns and young babies are more vulnerable to severe infections than all other age groups. However, there is no fast and easy way to tell which microbes are involved, resulting in babies being both over- and under-treated with antibiotics that may or may not help them, contributing to antibiotic resistance and wasting limited resources. In a recently funded CIHR study, we will use whole-blood transcriptomics and advanced bioinformatic analyses including machine learning and clustering to determine specific transcriptomic signatures that identify babies who are infected by bacteria and require urgent antibiotics. Our ultimate goal is to develop a rapid, easy-to-use tool that can be used around the world to guide the diagnosis and treatment of babies with systemic infections such as sepsis.

Pathogen Genomics and Hypothetical Proteins

Since the completion of the first bacterial genome in 1995, we have seen massive technological advances and cost reduction in genome sequencing over the last 25 years. This has resulted in a large number of available bacterial genomes (263,273 bacterial genomes available on NCBI as of 2020/09/19). However, our ability to sequence a bacterial genome is much faster than we can functionally characterize the genome. For instance, even in perhaps the best-studied model organism, Escherichia coli K-12 MG1655, ~35% of its genome has poor functional annotations. These poorly annotated genes, typically named as ‘hypothetical proteins’, are propagated across genome databases as standard bioinformatic pipelines cannot predict their functions. Given that many of these hypothetical proteins play a critical role in host-pathogen interactions, we have developed a prioritization strategy to identify candidate genes for functional characterization. Specifically, we propose to (1) perform bioinformatic data analyses to identify conserved hypothetical proteins that are associated with resistance or virulence phenotypes, (2) validate these phenotypes experimentally in the lab using deletion mutants, followed by (3) protein expression, purification and biochemical characterization of interesting candidates. Current pathogens of interest include: Pseudomonas aeruginosa and Klebsiella pneumoniae.

Grants

CIHR Project Grant: Molecular epidemiology of neonatal sepsis in low- and middle- income countries

NSERC Discovery Grant: Dissecting the virulence and antibiotic resistance potential of Klebsiella pneumoniae in disparate environments

CFI-JELF: Centre for the systems biology of host-pathogen interactions

NHMRC-Ideas: Innate defense regulator peptide for protecting the preterm infant from postnatal sepsis

Honours & Awards

Banting Research Foundation – Discovery Award 2022

Mozilla Foundation – Network50

Related News

Every day, our researchers work towards breakthroughs to transform the lives of kids in BC and around the world. Learn about our latest innovations and advancements in child health.

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Congratulations CIHR Spring 2025 Project Grant recipients
Congratulations to BC Children’s Hospital Research Institute (BCCHR) and Women’s Health Research Institute (WHRI) investigators and their teams who were awarded funding through the Canadian Institutes of Health Research (CIHR) Spring 2025 Project Grant competition.
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Our Research

At BC Children’s, we are making discoveries that save lives and transform health care for children in our province and around the world. Our research portfolio includes basic, clinical, population, and public health research.

EXPLORE OUR RESEARCH

Amy Lee

BSc, MSc, PhD

Investigator, BC Children's Hospital

Academic Affiliations

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A plasma protein biomarker signature that differentiates acute rheumatic fever from related clinical presentations

Time-course transcriptomics reveals the impact of Treponema pallidum on microvascular endothelial cell function and phenotype

From Local to Systemic: The Journey of Tick Bite Biomarkers in Australian Patients

Molecular analysis of human tick-bitten skin yields signatures associated with distinct spatial and temporal trajectories - A proof-of-concept study

Pseudomonas aeruginosa in chronic lung disease: untangling the dysregulated host immune response

Factors associated with SARS-CoV-2 infection in unvaccinated children and young adults

DNA Methylation signatures underpinning blood neutrophil to lymphocyte ratio during first week of human life

Breastfeeding and Neonatal Age Influence Neutrophil-Driven Ontogeny of Blood Cell Populations in the First Week of Human Life

Concentration-dependent alterations in the human plasma proteome following controlled exposure to diesel exhaust

Predictive gene expression signature diagnoses neonatal sepsis before clinical presentation

Gene Expression Profiling in Pediatric Appendicitis

Angiogenesis-associated pathways play critical roles in neonatal sepsis outcomes

A Commentary on Multi-omics Data Integration in Systems Vaccinology

The role of engineered materials in mucosal vaccination strategies

Pathogen-associated gene discovery workflows for novel antivirulence therapeutic development

A systems biology approach to better understand human tick-borne diseases

Persistence is key: unresolved immune dysfunction is lethal in both COVID-19 and non-COVID-19 sepsis

Severe COVID-19 and non-COVID-19 severe sepsis converge transcriptionally after a week in the intensive care unit, indicating common disease mechanisms

Predicting severity in COVID-19 disease using sepsis blood gene expression signatures

Post-COVID symptoms are associated with endotypes reflecting poor inflammatory and hemostatic modulation

Validation of reference gene stability for miRNA quantification by reverse transcription quantitative PCR in the peripheral blood of patients with COVID-19 critical illness

Factors associated with severe acute respiratory syndrome-related coronavirus 2 infection in unvaccinated children and young adults

Dynamic gene expression analysis reveals distinct severity phases of immune and cellular dysregulation in COVID-19

Gut microbes shape microglia and cognitive function during malnutrition

BosR: A novel biofilm-specific regulator in Pseudomonas aeruginosa

Surviving the host: Microbial metabolic genes required for growth of Pseudomonas aeruginosa in physiologically-relevant conditions

Salt and surfactant coated filters with antiviral properties and low pressure drop for prospective SARS-CoV2 applications

Predicting sepsis severity at first clinical presentation: The role of endotypes and mechanistic signatures

A transcriptomic analysis of the effects of macrophage polarization and endotoxin tolerance on the response to Salmonella

Genomic insights into the diversity, virulence and resistance of Klebsiella pneumoniae extensively drug resistant clinical isolates

Different Disease Endotypes in Phenotypically Similar Vasculitides Affecting Small-to-Medium Sized Blood Vessels

Peptide 1018 inhibits swarming and influences Anr-regulated gene expression downstream of the stringent stress response in Pseudomonas aeruginosa

Machine Learning-Based Single Cell and Integrative Analysis Reveals That Baseline mDC Predisposition Correlates With Hepatitis B Vaccine Antibody Response

RNase III and RNase E Influence Posttranscriptional Regulatory Networks Involved in Virulence Factor Production, Metabolism, and Regulatory RNA Processing in Bordetella pertussis

Machine learning-based single cell and integrative analysis reveals that baseline mDC predisposition predicts protective Hepatitis B vaccine response

Human-induced pluripotent stem cell-derived macrophages for studying infection biology and immunology

Identification of novel targets of azithromycin activity against Pseudomonas aeruginosa grown in physiologically relevant media

Whole blood genome-wide transcriptome profiling and metagenomics next-generation sequencing in young infants with suspected sepsis in a low-and middle-income country: A study protocol

Aberrant cell migration contributes to defective airway epithelial repair in childhood wheeze

Systems Biology Approaches to Understanding the Human Immune System

Systems Biology Methods Applied to Blood and Tissue for a Comprehensive Analysis of Immune Response to Hepatitis B Vaccine in Adults

Utilizing Organoid and Air-Liquid Interface Models as a Screening Method in the Development of New Host Defense Peptides

Preparing for Life: Plasma Proteome Changes and Immune System Development During the First Week of Human Life

Ivacaftor or lumacaftor/ivacaftor treatment does not alter the core CF airway epithelial gene response to rhinovirus

The importance of reporting house dust mite endotoxin abundance: Impact on the lung transcriptome

Regional Dichotomy in Enteric Mucosal Immune Responses to a Persistent <i>Mycobacterium avium</i> ssp. <i>paratuberculosis</i> Infection

Multi-Omic Data Integration Allows Baseline Immune Signatures to Predict Hepatitis B Vaccine Response in a Small Cohort

MetaBridge: An Integrative Multi-Omics Tool for Metabolite-Enzyme Mapping

BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis

A Bovine Enteric <i>Mycobacterium</i> Infection Model to Analyze Parenteral Vaccine-Induced Mucosal Immunity and Accelerate Vaccine Discovery

Whole blood transcriptional responses of very preterm infants during late-onset sepsis

Rhinovirus Infection Drives Complex Host Airway Molecular Responses in Children With Cystic Fibrosis

The Stringent Stress Response Controls Proteases and Global Regulators under Optimal Growth Conditions in Pseudomonas aeruginosa

Characterization of immune responses and the lung transcriptome in a murine model of IL-33 challenge

Perturbations of the ZED1 pseudokinase activate plant immunity

Identifying Pseudomonas syringae Type III Secreted Effector Function via a Yeast Genomic Screen.

Dynamic molecular changes during the first week of human life follow a robust developmental trajectory

Characterization of Host Responses during Pseudomonas aeruginosa Acute Infection in the Lungs and Blood and after Treatment with the Synthetic Immunomodulatory Peptide IDR-1002

A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection

Yeast Genomic Screens Identify Kinesins as Potential Targets of the Pseudomonas syringae Type III Effector, HopZ1a

Retinoic acid elicits a coordinated expression of gut homing markers on T lymphocytes of Zambian men receiving oral Vivotif, but not Rotarix, Dukoral or OPVERO vaccines.

MetaBridge: enabling network-based integrative analysis via direct protein interactors of metabolites

Comparative functional genomic screens of three yeast deletion collections reveal unexpected effects of genotype in response to diverse stress.

Phenotypic diversity and genotypic flexibility of Burkholderia cenocepacia during long-term chronic infection of cystic fibrosis lungs.

Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis.

hackseq: Catalyzing collaboration between biological and computational scientists via hackathon.

Mechanisms of the Innate Defense Regulator Peptide-1002 Anti-Inflammatory Activity in a Sterile Inflammation Mouse Model

Functional Genomics Using the Saccharomyces cerevisiae Yeast Deletion Collections.

Functional Profiling Using the Saccharomyces Genome Deletion Project Collections.

The Arabidopsis ZED1 pseudokinase is required for ZAR1-mediated immunity induced by the Pseudomonas syringae type III effector HopZ1a.

Phytopathogen type III effectors as probes of biological systems.