As a neonatologist who cares for small and sick newborns, I am interested in improving the short-term and long-term outcomes of patients in the Neonatal Intensive Care Unit (NICU). I am part of a Canadian team that is testing a new method (EPIC) for improving outcomes by implementing what has been proven and learning from NICUs with good outcomes. I am coordinating the team that is implementing this method to reduce infections. After these newborns go home, I study the well-being and outcome of those who have survived extreme prematurity, severe illness in the newborn period and other factors that put children at high risk of long term developmental disabilities. In addition, I am interested in finding the best way to ensure that these survivors have access to the effective treatments, health and educational services they may require.


Mortality and significant neurosensory impairment in preterm infants: an international comparison
Archives of Disease in Childhood - Fetal and Neonatal Edition
Marie Chevallier and Thierry Debillon and Brian A Darlow and Anne R Synnes and Véronique Pierrat and Elizabeth Hurrion and Junmin Yang and Anne Ego and Pierre Yves Ancel and Kei Lui and Prakeshkumar S Shah and Thuy Mai Luu
DOI: 10.1136/archdischild-2021-322288

Sensory processing and cortisol at age 4 years: Procedural pain-related stress in children born very preterm
Developmental Psychobiology
Mia A. McLean and Nikoo Niknafs and Olivia C. Scoten and Cecil M. Y. Chau and Margot MacKay and Joanne Weinberg and Anne Synnes and Steven P. Miller and Ruth E. Grunau
DOI: 10.1002/dev.22079

Head circumference, total cerebral volume and neurodevelopment in preterm neonates
Archives of Disease in Childhood - Fetal and Neonatal Edition
Thiviya Selvanathan and Ting Guo and Eddie Kwan and Vann Chau and Rollin Brant and Anne R Synnes and Ruth E Grunau and Steven P Miller
DOI: 10.1136/archdischild-2020-321397

Neurodevelopmental outcomes of singleton large for gestational age infants
Journal of Perinatology
Deepika Rustogi and Anne Synnes and Belal Alshaikh and Shabih Hasan and Christine Drolet and Edith Masse and Prashanth Murthy and Prakesh S. Shah and Kamran Yusuf and Prakesh S. Shah and Marc Beltempo and Jaideep Kanungo and Joseph Ting and Ayman Abou Mehrem and Jennifer Toye and Khalid Aziz and Jaya Bodani and Lannae Strueby and Mary Seshia and Deepak Louis and Ruben Alvaro and Amit Mukerji and Orlando Da Silva and Sajit Augustine and Kyong-Soon Lee and Eugene Ng and Brigitte Lemyre and Thierry Daboval and Faiza Khurshid and Victoria Bizgu and Keith Barrington and Christine Drolet and Bruno Piedboeuf and Martine Claveau and Valerie Bertelle and Edith Masse and Roderick Canning and Hala Makary and Cecil Ojah and Luis Monterrosa and Julie Emberley and Jehier Afifi and Andrzej Kajetanowicz and Shoo K. Lee and Thevanisha Pillay and Anne Synnes and Leonora Hendson and Amber Reichert and Matthew Hicks and Cecilia de Cabo and Chukwuma Nwaesei and Linh Ly and Edmond Kelly and Karen Thomas and
DOI: 10.1038/s41372-021-01080-z

Parent-reported health status of preterm survivors in a Canadian cohort
Archives of Disease in Childhood - Fetal and Neonatal Edition
Satvinder Ghotra and David Feeny and Ronald Barr and Junmin Yang and Saroj Saigal and Michael Vincer and Jehier Afifi and Prakeshkumar S Shah and Shoo K Lee and Anne R Synnes
DOI: 10.1136/archdischild-2021-321635

Family integrated care: very preterm neurodevelopmental outcomes at 18 months
Archives of Disease in Childhood - Fetal and Neonatal Edition
Anne R Synnes and Julie Petrie and Ruth E Grunau and Paige Church and Edmond Kelly and Diane Moddemann and Xiang Ye and Shoo K Lee and Karel O'Brien
DOI: 10.1136/archdischild-2020-321055

Risk factors for re-hospitalization following neonatal discharge of extremely preterm infants in Canada
Paediatrics & Child Health
Zakariya Bambala Puthattayil and Thuy Mai Luu and Marc Beltempo and Shannon Cross and Thevanisha Pillay and Marilyn Ballantyne and Anne Synnes and Prakesh Shah and Thierry Daboval and Thevanisha Pillay and Anne Synnes and Leonora Hendson and Amber Reichert and Jaya Bodani and Sibasis Daspal and Diane Moddemann and Chukwuma Nwaesei and Thierry Daboval and Sarah McKnight and Kevin Coughlin and Linh Ly and Edmond Kelly and Saroj Saigal and Karen Thomas and Paige Church and Ermelinda Pelausa and M Khairy and Thuy Mai Luu and Charlotte Demers and Alyssa Morin, Dr. and Sylvie Bélanger and Roderick Canning and Luis Monterrosa and Hala Makary and Jehier Afifi and Phil Murphy and Charles Janeway
DOI: 10.1093/pch/pxz143

Neonatal follow-up programs in Canada: A national survey
Paediatrics & Child Health
Fawaz Albaghli and Paige Church and Marilyn Ballantyne and Alberta Girardi and Anne Synnes
DOI: 10.1093/pch/pxz159

Mechanical Ventilation Duration, Brainstem Development, and Neurodevelopment in Children Born Preterm: A Prospective Cohort Study
The Journal of Pediatrics
Mireille Guillot and Ting Guo and Steven Ufkes and Juliane Schneider and Anne Synnes and Vann Chau and Ruth E. Grunau and Steven P. Miller
DOI: 10.1016/j.jpeds.2020.05.039

Association between Transport Risk Index of Physiologic Stability in Extremely Premature Infants and Mortality or Neurodevelopmental Impairment at 18 to 24 Months
The Journal of Pediatrics
Beate Grass and Xiang Y. Ye and Edmond Kelly and Anne Synnes and Shoo Lee
DOI: 10.1016/j.jpeds.2020.05.019

Antenatal magnesium sulphate and adverse neonatal outcomes: A systematic review and meta-analysis
PLOS Medicine
Emily Shepherd and Rehana A. Salam and Deepak Manhas and Anne Synnes and Philippa Middleton and Maria Makrides and Caroline A. Crowther
DOI: 10.1371/journal.pmed.1002988

Maternal smoking and neurodevelopmental outcomes in infants
Journal of Perinatology
Krystyna Ediger and Shabih U. Hasan and Anne Synnes and Jyotsna Shah and Dianne Creighton and Tetsuya Isayama and Prakesh S. Shah and Abhay Lodha
DOI: 10.1038/s41372-019-0356-3

Association of admission temperature and death or adverse neurodevelopmental outcomes in extremely low-gestational age neonates
Journal of Perinatology
Joseph Y. Ting and Anne R. Synnes and Shoo K. Lee and Prakesh S. Shah
DOI: 10.1038/s41372-018-0099-6

Early Procedural Pain Is Associated with Regionally-Specific Alterations in Thalamic Development in Preterm Neonates
The Journal of Neuroscience
Emma G. Duerden and Ruth E. Grunau and Ting Guo and Justin Foong and Alexander Pearson and Stephanie Au-Young and Raphael Lavoie and M. Mallar Chakravarty and Vann Chau and Anne Synnes and Steven P. Miller
DOI: 10.1523/JNEUROSCI.0867-17.2017

Determinants of developmental outcomes in a very preterm Canadian cohort
Archives of Disease in Childhood - Fetal and Neonatal Edition
Anne Synnes and Thuy Mai Luu and Diane Moddemann and Paige Church and David Lee and Michael Vincer and Marilyn Ballantyne and Annette Majnemer and Dianne Creighton and Junmin Yang and Reginald Sauve and Saroj Saigal and Prakesh Shah and Shoo K Lee
DOI: 10.1136/archdischild-2016-311228

Smaller Cerebellar Growth and Poorer Neurodevelopmental Outcomes in Very Preterm Infants Exposed to Neonatal Morphine
The Journal of Pediatrics
Jill G. Zwicker and Steven P. Miller and Ruth E. Grunau and Vann Chau and Rollin Brant and Colin Studholme and Mengyuan Liu and Anne Synnes and Kenneth J. Poskitt and Mikaela L. Stiver and Emily W.Y. Tam
DOI: 10.1016/j.jpeds.2015.12.024

Automatic segmentation of the hippocampus for preterm neonates from early-in-life to term-equivalent age
NeuroImage: Clinical
Ting Guo and Julie L. Winterburn and Jon Pipitone and Emma G. Duerden and Min Tae M. Park and Vann Chau and Kenneth J. Poskitt and Ruth E. Grunau and Anne Synnes and Steven P. Miller and M. Mallar Chakravarty
DOI: 10.1016/j.nicl.2015.07.019


Current projects
My research interests relate to improving the outcome of newborns in the Neonatal Intensive Care Units (NICUs) and into school age. I collaborate with the Canadian Neonatal Network, the Consortium for Health Intervention Learning and Development (CHILD) and Dr. Steven Miller.

I am the site investigator for a Canadian multicentre EPIC (Evidence based Practice Intervention and Change) NICU study which is testing the generalizability of EPIC. a new quality improvement methodology that incorporates evidence-based practices, tracking outcomes and quality improvement techniques. As site investigator for the CIHR team in Children’s Pain, we will be developing a Canadian pain database and evaluating whether EPIC can improve the assessment and management of pain in hospitalized children.

With the CHILD project, we have studied the survival and disabilities of extremely low birth weight children, extremely preterm children and those with severe intraventricular hemorrhages (bleed in the brain) in premature infants. We have used local databases to collect this information and are now exploring whether a provincial database linking the BC linked health database and the educational database can provide us with comprehensive information.

To better understand why some children develop disabilities, we are performing leading edge MRI studies of children born preterm, children with heart problems and children with hypoxic ischemic encephalopathy and will be comparing the MRI studies with the developmental outcome of these children at 1 ½ and 3 years of age.

Honours & Awards

Child & Youth Development Trajectories Research Unit, Michael Smith Foundation Research Unit Award - 2004

Canadian Neonatal Network, CIHR Knowledge Translation Award - 2004

Research Group Members

Amarpreet Chera, Undergraduate Research Assistant
Lindsay Richter, Research Coordinator