As a neonatologist who cares for small and sick newborns, I am interested in improving the short-term and long-term outcomes of patients in the Neonatal Intensive Care Unit (NICU). I am part of a Canadian team that is testing a new method (EPIC) for improving outcomes by implementing what has been proven and learning from NICUs with good outcomes. I am coordinating the team that is implementing this method to reduce infections. After these newborns go home, I study the well-being and outcome of those who have survived extreme prematurity, severe illness in the newborn period and other factors that put children at high risk of long term developmental disabilities. In addition, I am interested in finding the best way to ensure that these survivors have access to the effective treatments, health and educational services they may require.


Maternal smoking and neurodevelopmental outcomes in infants
Journal of Perinatology
Krystyna Ediger and Shabih U. Hasan and Anne Synnes and Jyotsna Shah and Dianne Creighton and Tetsuya Isayama and Prakesh S. Shah and Abhay Lodha
DOI: 10.1038/s41372-019-0356-3

Association of admission temperature and death or adverse neurodevelopmental outcomes in extremely low-gestational age neonates
Journal of Perinatology
Joseph Y. Ting and Anne R. Synnes and Shoo K. Lee and Prakesh S. Shah
DOI: 10.1038/s41372-018-0099-6

Early Procedural Pain Is Associated with Regionally-Specific Alterations in Thalamic Development in Preterm Neonates
The Journal of Neuroscience
Emma G. Duerden and Ruth E. Grunau and Ting Guo and Justin Foong and Alexander Pearson and Stephanie Au-Young and Raphael Lavoie and M. Mallar Chakravarty and Vann Chau and Anne Synnes and Steven P. Miller
DOI: 10.1523/JNEUROSCI.0867-17.2017

Determinants of developmental outcomes in a very preterm Canadian cohort
Archives of Disease in Childhood - Fetal and Neonatal Edition
Anne Synnes and Thuy Mai Luu and Diane Moddemann and Paige Church and David Lee and Michael Vincer and Marilyn Ballantyne and Annette Majnemer and Dianne Creighton and Junmin Yang and Reginald Sauve and Saroj Saigal and Prakesh Shah and Shoo K Lee
DOI: 10.1136/archdischild-2016-311228

Smaller Cerebellar Growth and Poorer Neurodevelopmental Outcomes in Very Preterm Infants Exposed to Neonatal Morphine
The Journal of Pediatrics
Jill G. Zwicker and Steven P. Miller and Ruth E. Grunau and Vann Chau and Rollin Brant and Colin Studholme and Mengyuan Liu and Anne Synnes and Kenneth J. Poskitt and Mikaela L. Stiver and Emily W.Y. Tam
DOI: 10.1016/j.jpeds.2015.12.024

Automatic segmentation of the hippocampus for preterm neonates from early-in-life to term-equivalent age
NeuroImage: Clinical
Ting Guo and Julie L. Winterburn and Jon Pipitone and Emma G. Duerden and Min Tae M. Park and Vann Chau and Kenneth J. Poskitt and Ruth E. Grunau and Anne Synnes and Steven P. Miller and M. Mallar Chakravarty
DOI: 10.1016/j.nicl.2015.07.019


Current projects
My research interests relate to improving the outcome of newborns in the Neonatal Intensive Care Units (NICUs) and into school age. I collaborate with the Canadian Neonatal Network, the Consortium for Health Intervention Learning and Development (CHILD) and Dr. Steven Miller.

I am the site investigator for a Canadian multicentre EPIC (Evidence based Practice Intervention and Change) NICU study which is testing the generalizability of EPIC. a new quality improvement methodology that incorporates evidence-based practices, tracking outcomes and quality improvement techniques. As site investigator for the CIHR team in Children’s Pain, we will be developing a Canadian pain database and evaluating whether EPIC can improve the assessment and management of pain in hospitalized children.

With the CHILD project, we have studied the survival and disabilities of extremely low birth weight children, extremely preterm children and those with severe intraventricular hemorrhages (bleed in the brain) in premature infants. We have used local databases to collect this information and are now exploring whether a provincial database linking the BC linked health database and the educational database can provide us with comprehensive information.

To better understand why some children develop disabilities, we are performing leading edge MRI studies of children born preterm, children with heart problems and children with hypoxic ischemic encephalopathy and will be comparing the MRI studies with the developmental outcome of these children at 1 ½ and 3 years of age.

Honours & Awards

Child & Youth Development Trajectories Research Unit, Michael Smith Foundation Research Unit Award - 2004

Canadian Neonatal Network, CIHR Knowledge Translation Award - 2004

Research Group Members

Lindsay Richter, Research Assistant