My area of interest is pediatric gastrointestinal complications, including examining current medical practices within Pediatric Gastroenterology. My main research focuses on using clinical trials and databases to increase understanding, improving methods of patient care, and evaluating whether alternative options of establishing diagnoses or care would be as, or more, efficacious and cost-effective as the care currently being given. Under these directives, a database project on GI complications in oncology patients is being completed. As well, alternative approaches for investigating celiac disease in order to streamline the process of its detection and diagnosis for both the patient and medical system are being researched. Concurrently, we are developing a project to analyze the effects of low body mass index for patients undergoing bone marrow transplants in order to see if this adversely affects their clinical outcomes. Finally, in collaboration with Dr. Rick Schreiber, a nation-wide study designed to look at the experience of patients with biliary artesia throughout Canada is being created.


25-Hydroxyvitamin D concentrations in children with Crohn's disease supplemented with either 2000 or 400 IU daily for 6 months: a randomized controlled study.
Wingate KE, Jacobson K, Issenman R, Carroll M, Barker C, Israel D, Brill H, Weiler H, Barr SI, Li W, Lyon MR, Green TJ
DOI: 10.1016/j.jpeds.2013.11.071
PubMed: 24423431

Biliary atresia with associated structural malformations in Canadian infants.
Guttman OR, Roberts EA, Schreiber RA, Barker CC, Ng VL, Canadian Pediatric Hepatology Research Group
DOI: 10.1111/j.1478-3231.2011.02578.x
PubMed: 21819536

Does adjuvant steroid therapy post-Kasai portoenterostomy improve outcome of biliary atresia? Systematic review and meta-analysis.
Sarkhy A, Schreiber RA, Milner RA, Barker CC
DOI: 10.1155/2011/125610
PubMed: 21912769

Childhood obesity and outcomes after bone marrow transplantation for patients with severe aplastic anemia.
Barker CC, Agovi MA, Logan B, Lazarus HM, Ballen KK, Gupta V, Hale GA, Frangoul H, Ho V, Rizzo JD, Pasquini MC, Regimen-Related Toxicity Writing Committee, Center for International Blood and Marrow Transplant Research
DOI: 10.1016/j.bbmt.2010.08.019
PubMed: 20817111

Endoscopic hemostasis in a neonate with a bleeding duodenal ulcer.
Lokesh Babu TG, Jacobson K, Phang M, Riley MR, Barker CC
DOI: 10.1097/01.mpg.0000173602.39271.ff
PubMed: 16056107

GI complications in pediatric patients post-BMT.
Barker CC, Anderson RA, Sauve RS, Butzner JD
DOI: 10.1038/sj.bmt.1705004
PubMed: 15908980

Can tissue transglutaminase antibody titers replace small-bowel biopsy to diagnose celiac disease in select pediatric populations?
Barker CC, Mitton C, Jevon G, Mock T
DOI: 10.1542/peds.2004-1392
PubMed: 15867045

Incidence, survival and risk factors for the development of veno-occlusive disease in pediatric hematopoietic stem cell transplant recipients.
Barker CC, Butzner JD, Anderson RA, Brant R, Sauve RS
DOI: 10.1038/sj.bmt.1704069
PubMed: 12815482

Neutropenic enterocolitis (typhlitis) after pediatric bone marrow transplant.
Otaibi AA, Barker C, Anderson R, Sigalet DL
DOI: 10.1053/jpsu.2002.32274
PubMed: 11987097

Crohn-like enteritis presenting as hypoglycemia in a patient with glycogen storage disease type 1b, treated with granulocyte colony-stimulating factor and splenectomy.
Barker CC, Butzner JD, Woodman RC, Parsons HG
DOI: 10.1097/00005176-200102000-00019
PubMed: 11321392

Beneficial effect of carnitine on mechanical recovery of rat hearts reperfused after a transient period of global ischemia is accompanied by a stimulation of glucose oxidation.
Broderick TL, Quinney HA, Barker CC, Lopaschuk GD
DOI: 10.1161/01.cir.87.3.972
PubMed: 8443916

Effects of high levels of fatty acids on functional recovery of ischemic hearts from diabetic rats.
Lopaschuk GD, Saddik M, Barr R, Huang L, Barker CC, Muzyka RA
PubMed: 1476176


Current Projects
The assessment of pediatric oncology patients for gastrointestinal complications and how to minimize these complications in this patient population by using databases to identify risk factors for adverse outcomes and recommendations to minimize these risk factors for future patients. Looking specifically at low body mass index and outcomes post stem cell transplantation. Assessment of the prevalence of lactose intolerance post stem cell transplantation and associated complications.

Examination of current medical practices within the pediatric gastroenterology division and using linked databases and prospective clinical trials to evaluate whether alternative options of establishing diagnoses or care would be as or more efficacious and cost-effective as the care is currently being given. Looking specifically at celiac disease and the screening TTG antibody test.

Research Group Members

Deborah Finlay, Admin Assistant, Gastroenterology