Overview

My area of interest is pediatric gastrointestinal complications, including examining current medical practices within Pediatric Gastroenterology. My main research focuses on using clinical trials and databases to increase understanding, improving methods of patient care, and evaluating whether alternative options of establishing diagnoses or care would be as, or more, efficacious and cost-effective as the care currently being given. Under these directives, a database project on GI complications in oncology patients is being completed. As well, alternative approaches for investigating celiac disease in order to streamline the process of its detection and diagnosis for both the patient and medical system are being researched. Concurrently, we are developing a project to analyze the effects of low body mass index for patients undergoing bone marrow transplants in order to see if this adversely affects their clinical outcomes. Finally, in collaboration with Dr. Rick Schreiber, a nation-wide study designed to look at the experience of patients with biliary artesia throughout Canada is being created.

Publications

25-Hydroxyvitamin D concentrations in children with Crohn's disease supplemented with either 2000 or 400 IU daily for 6 months: a randomized controlled study.
Wingate KE and Jacobson K and Issenman R and Carroll M and Barker C and Israel D and Brill H and Weiler H and Barr SI and Li W and Lyon MR and Green TJ
DOI: 10.1016/j.jpeds.2013.11.071
PubMed: 24423431
04/2014

Biliary atresia with associated structural malformations in Canadian infants.
Guttman OR and Roberts EA and Schreiber RA and Barker CC and Ng VL and Canadian Pediatric Hepatology Research Group
DOI: 10.1111/j.1478-3231.2011.02578.x
PubMed: 21819536
11/2011

Does adjuvant steroid therapy post-Kasai portoenterostomy improve outcome of biliary atresia? Systematic review and meta-analysis.
Sarkhy A and Schreiber RA and Milner RA and Barker CC
DOI: 10.1155/2011/125610
PubMed: 21912769
08/2011

Childhood obesity and outcomes after bone marrow transplantation for patients with severe aplastic anemia.
Barker CC and Agovi MA and Logan B and Lazarus HM and Ballen KK and Gupta V and Hale GA and Frangoul H and Ho V and Rizzo JD and Pasquini MC and Regimen-Related Toxicity Writing Committee and Center for International Blood and Marrow Transplant Research
DOI: 10.1016/j.bbmt.2010.08.019
PubMed: 20817111
05/2011

Endoscopic hemostasis in a neonate with a bleeding duodenal ulcer.
Lokesh Babu TG and Jacobson K and Phang M and Riley MR and Barker CC
DOI: 10.1097/01.mpg.0000173602.39271.ff
PubMed: 16056107
08/2005

GI complications in pediatric patients post-BMT.
Barker CC and Anderson RA and Sauve RS and Butzner JD
DOI: 10.1038/sj.bmt.1705004
PubMed: 15908980
07/2005

Can tissue transglutaminase antibody titers replace small-bowel biopsy to diagnose celiac disease in select pediatric populations?
Barker CC and Mitton C and Jevon G and Mock T
DOI: 10.1542/peds.2004-1392
PubMed: 15867045
05/2005

Incidence, survival and risk factors for the development of veno-occlusive disease in pediatric hematopoietic stem cell transplant recipients.
Barker CC and Butzner JD and Anderson RA and Brant R and Sauve RS
DOI: 10.1038/sj.bmt.1704069
PubMed: 12815482
07/2003

Neutropenic enterocolitis (typhlitis) after pediatric bone marrow transplant.
Otaibi AA and Barker C and Anderson R and Sigalet DL
DOI: 10.1053/jpsu.2002.32274
PubMed: 11987097
05/2002

Crohn-like enteritis presenting as hypoglycemia in a patient with glycogen storage disease type 1b, treated with granulocyte colony-stimulating factor and splenectomy.
Barker CC and Butzner JD and Woodman RC and Parsons HG
DOI: 10.1097/00005176-200102000-00019
PubMed: 11321392
02/2001

Beneficial effect of carnitine on mechanical recovery of rat hearts reperfused after a transient period of global ischemia is accompanied by a stimulation of glucose oxidation.
Broderick TL and Quinney HA and Barker CC and Lopaschuk GD
DOI: 10.1161/01.cir.87.3.972
PubMed: 8443916
03/1993

Effects of high levels of fatty acids on functional recovery of ischemic hearts from diabetic rats.
Lopaschuk GD and Saddik M and Barr R and Huang L and Barker CC and Muzyka RA
PubMed: 1476176
12/1992

Research

Current Projects
The assessment of pediatric oncology patients for gastrointestinal complications and how to minimize these complications in this patient population by using databases to identify risk factors for adverse outcomes and recommendations to minimize these risk factors for future patients. Looking specifically at low body mass index and outcomes post stem cell transplantation. Assessment of the prevalence of lactose intolerance post stem cell transplantation and associated complications.

Examination of current medical practices within the pediatric gastroenterology division and using linked databases and prospective clinical trials to evaluate whether alternative options of establishing diagnoses or care would be as or more efficacious and cost-effective as the care is currently being given. Looking specifically at celiac disease and the screening TTG antibody test.

Research Group Members

Deborah Finlay, Admin Assistant, Gastroenterology