My area of interest is pediatric gastrointestinal complications, including examining current medical practices within Pediatric Gastroenterology. My main research focuses on using clinical trials and databases to increase understanding, improving methods of patient care, and evaluating whether alternative options of establishing diagnoses or care would be as, or more, efficacious and cost-effective as the care currently being given. Under these directives, a database project on GI complications in oncology patients is being completed. As well, alternative approaches for investigating celiac disease in order to streamline the process of its detection and diagnosis for both the patient and medical system are being researched. Concurrently, we are developing a project to analyze the effects of low body mass index for patients undergoing bone marrow transplants in order to see if this adversely affects their clinical outcomes. Finally, in collaboration with Dr. Rick Schreiber, a nation-wide study designed to look at the experience of patients with biliary artesia throughout Canada is being created.
25-Hydroxyvitamin D concentrations in children with Crohn's disease supplemented with either 2000 or 400 IU daily for 6 months: a randomized controlled study. Wingate KE and Jacobson K and Issenman R and Carroll M and Barker C and Israel D and Brill H and Weiler H and Barr SI and Li W and Lyon MR and Green TJ DOI: 10.1016/j.jpeds.2013.11.071 PubMed: 24423431 04/2014
Biliary atresia with associated structural malformations in Canadian infants. Guttman OR and Roberts EA and Schreiber RA and Barker CC and Ng VL and Canadian Pediatric Hepatology Research Group DOI: 10.1111/j.1478-3231.2011.02578.x PubMed: 21819536 11/2011
Does adjuvant steroid therapy post-Kasai portoenterostomy improve outcome of biliary atresia? Systematic review and meta-analysis. Sarkhy A and Schreiber RA and Milner RA and Barker CC DOI: 10.1155/2011/125610 PubMed: 21912769 08/2011
Childhood obesity and outcomes after bone marrow transplantation for patients with severe aplastic anemia. Barker CC and Agovi MA and Logan B and Lazarus HM and Ballen KK and Gupta V and Hale GA and Frangoul H and Ho V and Rizzo JD and Pasquini MC and Regimen-Related Toxicity Writing Committee and Center for International Blood and Marrow Transplant Research DOI: 10.1016/j.bbmt.2010.08.019 PubMed: 20817111 05/2011
GI complications in pediatric patients post-BMT. Barker CC and Anderson RA and Sauve RS and Butzner JD DOI: 10.1038/sj.bmt.1705004 PubMed: 15908980 07/2005
Can tissue transglutaminase antibody titers replace small-bowel biopsy to diagnose celiac disease in select pediatric populations? Barker CC and Mitton C and Jevon G and Mock T DOI: 10.1542/peds.2004-1392 PubMed: 15867045 05/2005
Incidence, survival and risk factors for the development of veno-occlusive disease in pediatric hematopoietic stem cell transplant recipients. Barker CC and Butzner JD and Anderson RA and Brant R and Sauve RS DOI: 10.1038/sj.bmt.1704069 PubMed: 12815482 07/2003
Neutropenic enterocolitis (typhlitis) after pediatric bone marrow transplant. Otaibi AA and Barker C and Anderson R and Sigalet DL DOI: 10.1053/jpsu.2002.32274 PubMed: 11987097 05/2002
Crohn-like enteritis presenting as hypoglycemia in a patient with glycogen storage disease type 1b, treated with granulocyte colony-stimulating factor and splenectomy. Barker CC and Butzner JD and Woodman RC and Parsons HG DOI: 10.1097/00005176-200102000-00019 PubMed: 11321392 02/2001
Beneficial effect of carnitine on mechanical recovery of rat hearts reperfused after a transient period of global ischemia is accompanied by a stimulation of glucose oxidation. Broderick TL and Quinney HA and Barker CC and Lopaschuk GD DOI: 10.1161/01.cir.87.3.972 PubMed: 8443916 03/1993
Effects of high levels of fatty acids on functional recovery of ischemic hearts from diabetic rats. Lopaschuk GD and Saddik M and Barr R and Huang L and Barker CC and Muzyka RA PubMed: 1476176 12/1992
Current Projects The assessment of pediatric oncology patients for gastrointestinal complications and how to minimize these complications in this patient population by using databases to identify risk factors for adverse outcomes and recommendations to minimize these risk factors for future patients. Looking specifically at low body mass index and outcomes post stem cell transplantation. Assessment of the prevalence of lactose intolerance post stem cell transplantation and associated complications.
Examination of current medical practices within the pediatric gastroenterology division and using linked databases and prospective clinical trials to evaluate whether alternative options of establishing diagnoses or care would be as or more efficacious and cost-effective as the care is currently being given. Looking specifically at celiac disease and the screening TTG antibody test.
Human DNA testing could improve outcomes for patients with COVID-19.
That’s the key idea put forth in preliminary research posted this month to bioRxiv that highlights the potential benefits of testing COVID-19 patients for genetic variants of ACE2—the protein identified as the point-of-entry for the SARS-COV-2 virus into human cells.
Congratulations to the BC Children's and BC Women's investigators who were awarded funding through the highly competitive Canadian Institutes of Health Research (CIHR) Project Grant Fall 2019 competition.
A new study suggests that specialized immune cells that dampen inflammation and help repair the gut could be used as a potential therapy for children dealing with the painful symptoms of inflammatory bowel disease.
We believe there’s nothing we can’t do with your support. It can take years to turn scientific breakthrough into new interventions and treatments. Funding helps speed the pace of change. When given the resources, we can bring transformative therapies – and hope – out of the laboratory and into the clinic to save and improve children’s lives.