Overview

My areas of research are in diabetes and endocrine disorders in children. One particular area of focus is in late endocrine effects of childhood cancer survivors. Some children who have undergone oncological treatment are at an increased risk of a vast array of endocrine disorders, ranging from hormone disruption to impacted bone health. My interest is to further understand the risks, monitoring and management of these endo-oncological issues. A second area of focus is in diabetes technology in the management of childhood diabetes care. I am interested in understanding the current use of technology, and to generate innovative and systematic ways to successfully incorporate technology into our existing care model.

Publications

Severe Primary Hyperparathyroidism Caused by Parathyroid Carcinoma in a 13-Year-Old Child; Novel Findings From HRpQCT.
JBMR plus
Lenherr-Taube N and Lam CK and Vali R and Shammas A and Campisi P and Zawawi F and Somers GR and Stimec J and Mete O and Wong AK and Sochett E
DOI: 10.1002/jbm4.10324
PubMed: 32161840
01/2020

Seeing Clearly: Effects of Initiatives to Improve Diabetic Retinopathy Screening at a Pediatric Center
Clinical Diabetes
Carol K.L. Lam and Stephen Zborovski and Mark R. Palmert and Jennifer Harrington
DOI: 10.2337/cd18-0084
02/2019

Long-term Exposure of Children to a Mixed Lipid Emulsion Is Less Hepatotoxic Than Soybean-based Lipid Emulsion
Journal of Pediatric Gastroenterology & Nutrition
Carol K.L. Lam and Peter C. Church and Beth Haliburton and Kathryn Chambers and Inez Martincevic and Laura Vresk and Glenda Courtney-Martin and Robert Bandsma and Yaron Avitzur and Paul C. Wales and Marialena Mouzaki
DOI: 10.1097/mpg.0000000000001799
03/2018

More Frequent Clinic Visits Are Associated with Improved Outcomes for Children with NAFLD
Canadian Journal of Gastroenterology and Hepatology
Lam, C. and Bandsma, R. and Ling, S. and Mouzaki, M.
DOI: 10.1155/2016/8205494
2016

Long-term inflammation and glucocorticoid therapy impair skeletal modeling during growth in childhood crohn disease
Journal of Clinical Endocrinology and Metabolism
Tsampalieros, A. and Lam, C.K.L. and Spencer, J.C. and Thayu, M. and Shults, J. and Zemel, B.S. and Herskovitz, R.M. and Baldassano, R.N. and Leonard, M.B.
DOI: 10.1210/jc.2013-1631
2013

Hypothalamic glucagon signaling inhibits hepatic glucose production
Nature Medicine
Mighiu, P.I. and Yue, J.T.Y. and Filippi, B.M. and Abraham, M.A. and Chari, M. and Lam, C.K.L. and Yang, C.S. and Christian, N.R. and Charron, M.J. and Lam, T.K.T.
DOI: 10.1038/nm.3115
2013

Duodenal mucosal protein kinase C-d regulates glucose production in rats
Gastroenterology
Kokorovic, A. and Cheung, G.W.C. and Breen, D.M. and Chari, M. and Lam, C.K.L. and Lam, T.K.T.
DOI: 10.1053/j.gastro.2011.06.042
2011

Glucose transporter-1 in the hypothalamic glial cells mediates glucose sensing to regulate glucose production in vivo
Diabetes
Chari, M. and Yang, C.S. and Lam, C.K.L. and Lee, K. and Mighiu, P. and Kokorovic, A. and Cheung, G.W.C. and Lai, T.Y.Y. and Wang, P.Y.T. and Lam, T.K.T.
DOI: 10.2337/db11-0120
2011

Hypothalamic nutrient sensing activates a forebrain-hindbrain neuronal circuit to regulate glucose production in vivo
Diabetes
Lam, C.K.L. and Chari, M. and Rutter, G.A. and Lam, T.K.T.
DOI: 10.2337/db10-0994
2011

Hypothalamic AMP-activated protein kinase regulates glucose production
Diabetes
Yang, C.S. and Lam, C.K.L. and Chari, M. and Cheung, G.W.C. and Kokorovic, A. and Gao, S. and Leclerc, I. and Rutter, G.A. and Lam, T.K.T.
DOI: 10.2337/db10-0221
2010

Activation of N-methyl-D-aspartate (NMDA) receptors in the dorsal vagal complex lowers glucose production
Journal of Biological Chemistry
Lam, C.K.L. and Chari, M. and Su, B.B. and Cheung, G.W.C. and Kokorovic, A. and Yang, C.S. and Wang, P.Y.T. and Lai, T.Y.Y. and Lam, T.K.T.
DOI: 10.1074/jbc.M109.087338
2010

Intestinal Cholecystokinin Controls Glucose Production through a Neuronal Network
Cell Metabolism
Cheung, G.W.C. and Kokorovic, A. and Lam, C.K.L. and Chari, M. and Lam, T.K.T.
DOI: 10.1016/j.cmet.2009.07.005
2009

CNS regulation of glucose homeostasis
Physiology
Lam, C.K.L. and Chari, M. and Lam, T.K.T.
DOI: 10.1152/physiol.00003.2009
2009

Hypothalamic protein kinase C regulates glucose production
Diabetes
Ross, R. and Wang, P.Y.T. and Chari, M. and Lam, C.K.L. and Caspi, L. and Ono, H. and Muse, E.D. and Li, X. and Gutierrez-Juarez, R. and Light, P.E. and Schwartz, G.J. and Rossetti, L. and Lam, T.K.T.
DOI: 10.2337/db08-0206
2008

Central lactate metabolism regulates food intake
American Journal of Physiology - Endocrinology and Metabolism
Lam, C.K.L. and Chari, M. and Wang, P.Y.T. and Lam, T.K.T.
DOI: 10.1152/ajpendo.90481.2008
2008

Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production
Nature
Wang, P.Y.T. and Caspi, L. and Lam, C.K.L. and Chari, M. and Li, X. and Light, P.E. and Gutierrez-Juarez, R. and Ang, M. and Schwartz, G.J. and Lam, T.K.T.
DOI: 10.1038/nature06852
2008

Activation of central lactate metabolism lowers glucose production in uncontrolled diabetes and diet-induced insulin resistance
Diabetes
Chari, M. and Lam, C.K.L. and Wang, P.Y.T. and Lam, T.K.T.
DOI: 10.2337/db07-1464
2008

Insulin resistance and decreased glucose-stimulated insulin secretion after acute olanzapine administration
Journal of Clinical Psychopharmacology
Chintoh, A.F. and Mann, S.W. and Lam, L. and Lam, C. and Cohn, T.A. and Fletcher, P.J. and Nobrega, J.N. and Giacca, A. and Remington, G.
DOI: 10.1097/JCP.0b013e318184b4c5
2008

Research

Diabetes Technology Pathway
There is rapid advancement in technology for the management of diabetes in children. This project aims to understand the current landscape of diabetes technology, and to create a model that can establish successful incorporation of technology in pediatric diabetes care.