Carol Lam

MD, MSc, FRCPC

Affiliate Investigator, BC Children's Hospital
Pediatric Endocrinologist, SickKids
Assistant Professor, University of Toronto

My areas of research are in diabetes and endocrine disorders in children. One particular area of focus is in late endocrine effects of childhood cancer survivors. Some children who have undergone oncological treatment are at an increased risk of a vast array of endocrine disorders, ranging from hormone disruption to impacted bone health. My interest is to further understand the risks, monitoring and management of these endo-oncological issues. A second area of focus is in diabetes technology in the management of childhood diabetes care. I am interested in understanding the current use of technology, and to generate innovative and systematic ways to successfully incorporate technology into our existing care model.

Academic Affiliations

  • Adjunct Professor, , Department of Pediatrics, Faculty of Medicine, University of British Columbia
  • Research Theme: Evidence to Innovation
  • Research Group(s): Clinical Practice, Outcomes and Innovation; Diabetes; Implementing Knowledge for Equity and System Change

Contact Information

Scaphoid Reconstruction Following Nonunion in Osteogenesis Imperfecta: A Case Report

Jbjs Case Connector

Lenartowicz, K.A. and Paul, R.A. and Howard, A. and Persitz, J. and Lam, C. and Chan, A.H.W.

DOI: 10.2106/JBJS.CC.25.00116

Primary gonadal failure in children with intracranial brain tumors treated with high dose alkylating agents and radiation sparing therapy: an institutional case series

Pediatric Hematology and Oncology

Cheng, S. and Riedlinger, S. and Ronsley, R. and Stewart, L. and Hukin, J. and Lam, C.K.L.

DOI: 10.1080/08880018.2025.2480741

Long-term health outcomes of preterm birth: a narrative review

Frontiers in Pediatrics

Gette, F. and Aziz Ali, S. and Ho, M.S.P. and Richter, L.L. and Chan, E.S. and Yang, C.L. and Kieran, E. and Mammen, C. and Roberts, A. and Kang, K.T. and Wong, J. and Rassekh, S.R. and Castaldo, M. and Harris, K.C. and Lee, J. and Lam, C.K.L. and Chan, N.H. and Lisonkova, S. and Ting, J.Y.

DOI: 10.3389/fped.2025.1565897

Diazoxide-related Hyperglycemic Hyperosmolar State in a Child With Kabuki Syndrome

JCEM Case Reports

Harsh Kahlon and Joshua R Stanley and Cillian Lineen and Carol Lam

DOI: 10.1210/jcemcr/luae108

06 / 2024

Maternal Vitamin D Supplementation and Infantile Rickets: Secondary Analysis of a Randomized Trial

Pediatrics

Lautatzis, M.-E. and Keya, F.K. and Al Mahmud, A. and Tariq, U. and Lam, C. and Morris, S.K. and Stimec, J. and Zlotkin, S. and Ahmed, T. and Harrington, J. and Roth, D.E.

DOI: 10.1542/peds.2023-063263

Impact of Perinatal Exposure to SARS-CoV-2 Infection on Early Health Outcomes among Infants Born from 2020 to 2021 in British Columbia, Canada

Canadian Journal of Infectious Diseases and Medical Microbiology

Richter, L.L. and Ho, M.S.P. and Zhang, Q. and Bone, J.N. and Portales-Casamar, E. and Yang, C.L. and Roberts, A. and Kang, K. and Kieran, E. and Lam, C. and Lisonkova, S. and Ting, J.Y.

DOI: 10.1155/2023/9968774

Intranasal Carbetocin Reduces Hyperphagia, Anxiousness, and Distress in Prader-Willi Syndrome: CARE-PWS Phase 3 Trial

Journal of Clinical Endocrinology and Metabolism

Roof, E. and Deal, C.L. and McCandless, S.E. and Cowan, R.L. and Miller, J.L. and Hamilton, J.K. and Roeder, E.R. and McCormack, S.E. and Roshan Lal, T.R. and Abdul-Latif, H.D. and Haqq, A.M. and Obrynba, K.S. and Torchen, L.C. and Vidmar, A.P. and Viskochil, D.H. and Chanoine, J.-P. and Lam, C.K.L. and Pierce, M.J. and Williams, L.L. and Bird, L.M. and Butler, M.G. and Jensen, D.E. and Myers, S.E. and Oatman, O.J. and Baskaran, C. and Chalmers, L.J. and Fu, C. and Alos, N. and McLean, S.D. and Shah, A. and Whitman, B.Y. and Blumenstein, B.A. and Leonard, S.F. and Ernest, J.P. and Cormier, J.W. and Cotter, S.P. and Ryman, D.C.

DOI: 10.1210/clinem/dgad015

Erratum: Diagnosis of adrenal insufficiency in children: A survey among pediatric endocrinologists in North America (Journal of Pediatric Endocrinology and Metabolism DOI: 10.1515/jpem-2022-0444)

Journal of Pediatric Endocrinology and Metabolism

Silva, C. and Patel, T. and Lam, C.

DOI: 10.1515/jpem-2023-0205

Diagnosis of adrenal insufficiency in children: A survey among pediatric endocrinologists in North America

Journal of Pediatric Endocrinology and Metabolism

Silva, C. and Patel, T.J. and Lam, C.

DOI: 10.1515/jpem-2022-0444

Severe Primary Hyperparathyroidism Caused by Parathyroid Carcinoma in a 13-Year-Old Child; Novel Findings From HRpQCT.

JBMR plus

Lenherr-Taube N and Lam CK and Vali R and Shammas A and Campisi P and Zawawi F and Somers GR and Stimec J and Mete O and Wong AK and Sochett E

DOI: 10.1002/jbm4.10324 PubMed: 32161840

01 / 2020

Seeing Clearly: Effects of Initiatives to Improve Diabetic Retinopathy Screening at a Pediatric Center

Clinical Diabetes

Carol K.L. Lam and Stephen Zborovski and Mark R. Palmert and Jennifer Harrington

DOI: 10.2337/cd18-0084

02 / 2019

Long-term Exposure of Children to a Mixed Lipid Emulsion Is Less Hepatotoxic Than Soybean-based Lipid Emulsion

Journal of Pediatric Gastroenterology & Nutrition

Carol K.L. Lam and Peter C. Church and Beth Haliburton and Kathryn Chambers and Inez Martincevic and Laura Vresk and Glenda Courtney-Martin and Robert Bandsma and Yaron Avitzur and Paul C. Wales and Marialena Mouzaki

DOI: 10.1097/mpg.0000000000001799

03 / 2018

More Frequent Clinic Visits Are Associated with Improved Outcomes for Children with NAFLD

Canadian Journal of Gastroenterology and Hepatology

Lam, C. and Bandsma, R. and Ling, S. and Mouzaki, M.

DOI: 10.1155/2016/8205494

Hypothalamic glucagon signaling inhibits hepatic glucose production

Nature Medicine

Mighiu, P.I. and Yue, J.T.Y. and Filippi, B.M. and Abraham, M.A. and Chari, M. and Lam, C.K.L. and Yang, C.S. and Christian, N.R. and Charron, M.J. and Lam, T.K.T.

DOI: 10.1038/nm.3115

Long-term inflammation and glucocorticoid therapy impair skeletal modeling during growth in childhood crohn disease

Journal of Clinical Endocrinology and Metabolism

Tsampalieros, A. and Lam, C.K.L. and Spencer, J.C. and Thayu, M. and Shults, J. and Zemel, B.S. and Herskovitz, R.M. and Baldassano, R.N. and Leonard, M.B.

DOI: 10.1210/jc.2013-1631

Hypothalamic nutrient sensing activates a forebrain-hindbrain neuronal circuit to regulate glucose production in vivo

Diabetes

Lam, C.K.L. and Chari, M. and Rutter, G.A. and Lam, T.K.T.

DOI: 10.2337/db10-0994

Glucose transporter-1 in the hypothalamic glial cells mediates glucose sensing to regulate glucose production in vivo

Diabetes

Chari, M. and Yang, C.S. and Lam, C.K.L. and Lee, K. and Mighiu, P. and Kokorovic, A. and Cheung, G.W.C. and Lai, T.Y.Y. and Wang, P.Y.T. and Lam, T.K.T.

DOI: 10.2337/db11-0120

Duodenal mucosal protein kinase C-d regulates glucose production in rats

Gastroenterology

Kokorovic, A. and Cheung, G.W.C. and Breen, D.M. and Chari, M. and Lam, C.K.L. and Lam, T.K.T.

DOI: 10.1053/j.gastro.2011.06.042

Activation of N-methyl-D-aspartate (NMDA) receptors in the dorsal vagal complex lowers glucose production

Journal of Biological Chemistry

Lam, C.K.L. and Chari, M. and Su, B.B. and Cheung, G.W.C. and Kokorovic, A. and Yang, C.S. and Wang, P.Y.T. and Lai, T.Y.Y. and Lam, T.K.T.

DOI: 10.1074/jbc.M109.087338

Hypothalamic AMP-activated protein kinase regulates glucose production

Diabetes

Yang, C.S. and Lam, C.K.L. and Chari, M. and Cheung, G.W.C. and Kokorovic, A. and Gao, S. and Leclerc, I. and Rutter, G.A. and Lam, T.K.T.

DOI: 10.2337/db10-0221

CNS regulation of glucose homeostasis

Physiology

Lam, C.K.L. and Chari, M. and Lam, T.K.T.

DOI: 10.1152/physiol.00003.2009

Intestinal Cholecystokinin Controls Glucose Production through a Neuronal Network

Cell Metabolism

Cheung, G.W.C. and Kokorovic, A. and Lam, C.K.L. and Chari, M. and Lam, T.K.T.

DOI: 10.1016/j.cmet.2009.07.005

Activation of central lactate metabolism lowers glucose production in uncontrolled diabetes and diet-induced insulin resistance

Diabetes

Chari, M. and Lam, C.K.L. and Wang, P.Y.T. and Lam, T.K.T.

DOI: 10.2337/db07-1464

Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production

Nature

Wang, P.Y.T. and Caspi, L. and Lam, C.K.L. and Chari, M. and Li, X. and Light, P.E. and Gutierrez-Juarez, R. and Ang, M. and Schwartz, G.J. and Lam, T.K.T.

DOI: 10.1038/nature06852

Hypothalamic protein kinase C regulates glucose production

Diabetes

Ross, R. and Wang, P.Y.T. and Chari, M. and Lam, C.K.L. and Caspi, L. and Ono, H. and Muse, E.D. and Li, X. and Gutierrez-Juarez, R. and Light, P.E. and Schwartz, G.J. and Rossetti, L. and Lam, T.K.T.

DOI: 10.2337/db08-0206

Insulin resistance and decreased glucose-stimulated insulin secretion after acute olanzapine administration

Journal of Clinical Psychopharmacology

Chintoh, A.F. and Mann, S.W. and Lam, L. and Lam, C. and Cohn, T.A. and Fletcher, P.J. and Nobrega, J.N. and Giacca, A. and Remington, G.

DOI: 10.1097/JCP.0b013e318184b4c5

Central lactate metabolism regulates food intake

American Journal of Physiology - Endocrinology and Metabolism

Lam, C.K.L. and Chari, M. and Wang, P.Y.T. and Lam, T.K.T.

DOI: 10.1152/ajpendo.90481.2008

Diabetes Technology Pathway

There is rapid advancement in technology for the management of diabetes in children. This project aims to understand the current landscape of diabetes technology, and to create a model that can establish successful incorporation of technology in pediatric diabetes care.

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At BC Children’s, we are making discoveries that save lives and transform health care for children in our province and around the world. Our research portfolio includes basic, clinical, population, and public health research.

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