My primary research interest lies in the field of pediatric acute kidney injury (AKI), which is defined as an abrupt and often reversible decline in renal function. AKI is a common occurrence in pediatric patients admitted to hospital and is caused by a variety of factors including dehydration, toxic medications, and low oxygen states. My current research work is focused on AKI in the pediatric intensive care unit (PICU) population and how AKI affects the long term renal function of these patients, years after their initial renal injury.
My secondary research interest is in the world of pediatric hemodialysis, one of the major forms of renal replacement therapy utilized in children with chronic kidney disease. I am particularly interested in evaluating various methods for quantifying the dose of chronic hemodialysis in children with end-stage kidney disease so that we can properly identify those patients which are being adequately dialyzed or not.
Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates: Design of a Retrospective Cohort Study.
Jetton JG, Guillet R, Askenazi DJ, Dill L, Jacobs J, Kent AL, Selewski DT, Abitbol CL, Kaskel FJ, Mhanna MJ, Ambalavanan N, Charlton JR, Neonatal Kidney Collaborative
Assessment of Worldwide Acute Kidney Injury, Renal Angina and Epidemiology in critically ill children (AWARE): study protocol for a prospective observational study.
Basu RK, Kaddourah A, Terrell T, Mottes T, Arnold P, Jacobs J, Andringa J, Goldstein SL, Prospective Pediatric AKI Research Group (ppAKI)
A severe phenotype of Gitelman syndrome with increased prostaglandin excretion and favorable response to indomethacin.
Larkins N, Wallis M, McGillivray B, Mammen C
Canadian Society of Nephrology Commentary on the 2012 KDIGO clinical practice guideline for glomerulonephritis: management of glomerulonephritis in adults.
Cybulsky AV, Walsh M, Knoll G, Hladunewich M, Bargman J, Reich H, Humar A, Samuel S, Bitzan M, Zappitelli M, Dart A, Mammen C, Pinsk M, Muirhead N
Canadian Society of Nephrology Commentary on the 2012 KDIGO clinical practice guideline for glomerulonephritis: management of nephrotic syndrome in children.
Samuel S, Bitzan M, Zappitelli M, Dart A, Mammen C, Pinsk M, Cybulsky AV, Walsh M, Knoll G, Hladunewich M, Bargman J, Reich H, Humar A, Muirhead N
The Canadian Childhood Nephrotic Syndrome (CHILDNEPH) Project: overview of design and methods.
Samuel S, Scott S, Morgan C, Dart A, Mammen C, Parekh R, Nettel-Aguirre A, Eddy A, Flynn R, Pinsk M, Wade A, Arora S, Benoit G, Bitzan M, Erickson R, Feber J, Filler G, Geier P, Girardin C, Grisaru S
Substantial practice variation exists in the management of childhood nephrotic syndrome.
Samuel S, Morgan CJ, Bitzan M, Mammen C, Dart AB, Manns BJ, Alexander RT, Erickson RL, Grisaru S, Wade AW, Blydt-Hansen T, Feber J, Arora S, Licht C, Zappitelli M
Epidemiology of cardiac surgery-associated acute kidney injury in neonates: a retrospective study.
Alabbas A, Campbell A, Skippen P, Human D, Matsell D, Mammen C
Long-term risk of CKD in children surviving episodes of acute kidney injury in the intensive care unit: a prospective cohort study.
Mammen C, Al Abbas A, Skippen P, Nadel H, Levine D, Collet JP, Matsell DG
Hypothesis: SLC12A3 Polymorphism modifies thiazide hypersensitivity of antenatal Bartter syndrome to thiazide resistance.
Mammen C, Rupps R, Trnka P, Boerkoel CF
Standard Kt/V thresholds to accurately predict single-pool Kt/V targets for children receiving thrice-weekly maintenance haemodialysis.
Mammen C, Goldstein SL, Milner R, White CT
Application of the Acute Kidney Injury Network (AKIN) Definition to Critically-Ill Children & Neonates.
A descriptive study analyzing AKI in the PICU at BC Children's Hospital from 2006-2008 through utilization of the AKIN definition with a direct comparison of the 3 severity classes of AKI (mild, moderate, severe) in terms of AKI etiologies, age, weight, risk of mortality scores, length of ICU stay, ventilation and other physiological parameters.
Small solute clearance in obese pediatric HD patients. White CT, Frankenfield, Goldstein SG, Mammen C, Neu AM.
A retrospective cohort study (2000-2008) utilizing data collected from the CMS ESRD Clinical Measures Project assessing the relationships between BMI and achievement of HD adequacy targets (spKt/V) through a logistic regression model.
Renal Outcomes of Acute Kidney Injury in the Pediatric ICU: A prospective cohort study
A longitudinal study to determine the incidence of chronic kidney disease (CKD) and to identify predictors of CKD in pediatric patients who have sustained Acute Kidney Injury (AKI) at BC Children's Hospital PICU from 2006-2008.Grants
Title: Renal Outcomes Following Acute Kidney Injury in the Pediatric Intensive Care Unit: A Prospective Cohort Study. Granting Agency: Clinician Investigator Program, UBC. Salary Support: $65,000 x 2 yrs (2009-1010) Role: Principal Investigator.Honours & Awards
Clinician Investigator Program (CIP), UBC, Vancouver, BC. (2009-2010) --- The aim of the CIP is to encourage young physicians to pursue careers as clinician scientists. Selection to this competitive, 2-year funded research fellowship program based on application including formal research grant proposal.