Overview

My primary research interest lies in the field of pediatric acute kidney injury (AKI), which is defined as an abrupt and often reversible decline in renal function. AKI is a common occurrence in pediatric patients admitted to hospital and is caused by a variety of factors including dehydration, toxic medications, and low oxygen states. My current research work is focused on AKI in the pediatric intensive care unit (PICU) population and how AKI affects the long term renal function of these patients, years after their initial renal injury.

My secondary research interest is in the world of pediatric hemodialysis, one of the major forms of renal replacement therapy utilized in children with chronic kidney disease. I am particularly interested in evaluating various methods for quantifying the dose of chronic hemodialysis in children with end-stage kidney disease so that we can properly identify those patients which are being adequately dialyzed or not.

Publications

The path to chronic kidney disease following acute kidney injury: a neonatal perspective.
Chaturvedi S and Ng KH and Mammen C
DOI: 10.1007/s00467-015-3298-9
PubMed: 26809804
02/2017

Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates: Design of a Retrospective Cohort Study.
Jetton JG and Guillet R and Askenazi DJ and Dill L and Jacobs J and Kent AL and Selewski DT and Abitbol CL and Kaskel FJ and Mhanna MJ and Ambalavanan N and Charlton JR and Neonatal Kidney Collaborative
DOI: 10.3389/fped.2016.00068
PubMed: 27486571
2016

Assessment of Worldwide Acute Kidney Injury, Renal Angina and Epidemiology in critically ill children (AWARE): study protocol for a prospective observational study.
Basu RK and Kaddourah A and Terrell T and Mottes T and Arnold P and Jacobs J and Andringa J and Goldstein SL and Prospective Pediatric AKI Research Group (ppAKI)
DOI: 10.1186/s12882-015-0016-6
PubMed: 25882434
02/2015

Acute encephalopathy in a kidney transplant recipient following infusion of intravenous immunoglobulin.
Wang L and Larkins N and Jung B and Au NH and Mammen C
DOI: 10.1111/tri.12384
PubMed: 24964219
11/2014

The importance of clinical pathways and protocols in pediatric nephrology.
Mammen C and Matsell DG and Lemley KV
DOI: 10.1007/s00467-013-2577-6
PubMed: 23955786
10/2014

A severe phenotype of Gitelman syndrome with increased prostaglandin excretion and favorable response to indomethacin.
Larkins N and Wallis M and McGillivray B and Mammen C
DOI: 10.1093/ckj/sfu029
PubMed: 25852896
06/2014

Canadian Society of Nephrology Commentary on the 2012 KDIGO clinical practice guideline for glomerulonephritis: management of glomerulonephritis in adults.
Cybulsky AV and Walsh M and Knoll G and Hladunewich M and Bargman J and Reich H and Humar A and Samuel S and Bitzan M and Zappitelli M and Dart A and Mammen C and Pinsk M and Muirhead N
DOI: 10.1053/j.ajkd.2013.12.001
PubMed: 24423780
03/2014

Canadian Society of Nephrology Commentary on the 2012 KDIGO clinical practice guideline for glomerulonephritis: management of nephrotic syndrome in children.
Samuel S and Bitzan M and Zappitelli M and Dart A and Mammen C and Pinsk M and Cybulsky AV and Walsh M and Knoll G and Hladunewich M and Bargman J and Reich H and Humar A and Muirhead N
DOI: 10.1053/j.ajkd.2013.12.002
PubMed: 24423782
03/2014

The Canadian Childhood Nephrotic Syndrome (CHILDNEPH) Project: overview of design and methods.
Samuel S and Scott S and Morgan C and Dart A and Mammen C and Parekh R and Nettel-Aguirre A and Eddy A and Flynn R and Pinsk M and Wade A and Arora S and Benoit G and Bitzan M and Erickson R and Feber J and Filler G and Geier P and Girardin C and Grisaru S
DOI: 10.1186/2054-3581-1-17
PubMed: 25960884
2014

Substantial practice variation exists in the management of childhood nephrotic syndrome.
Samuel S and Morgan CJ and Bitzan M and Mammen C and Dart AB and Manns BJ and Alexander RT and Erickson RL and Grisaru S and Wade AW and Blydt-Hansen T and Feber J and Arora S and Licht C and Zappitelli M
DOI: 10.1007/s00467-013-2546-0
PubMed: 23917450
12/2013

Epidemiology of cardiac surgery-associated acute kidney injury in neonates: a retrospective study.
Alabbas A and Campbell A and Skippen P and Human D and Matsell D and Mammen C
DOI: 10.1007/s00467-013-2454-3
PubMed: 23519522
07/2013

A rare cause of hypertension in a healthy 2-year-old female: questions.
Fox DA and Matsell DG and Hursh BE and Mammen C
DOI: 10.1007/s00467-012-2161-5
PubMed: 22534766
11/2012

Long-term risk of CKD in children surviving episodes of acute kidney injury in the intensive care unit: a prospective cohort study.
Mammen C and Al Abbas A and Skippen P and Nadel H and Levine D and Collet JP and Matsell DG
DOI: 10.1053/j.ajkd.2011.10.048
PubMed: 22206744
04/2012

Hypothesis: SLC12A3 Polymorphism modifies thiazide hypersensitivity of antenatal Bartter syndrome to thiazide resistance.
Mammen C and Rupps R and Trnka P and Boerkoel CF
DOI: 10.1016/j.ejmg.2011.12.006
PubMed: 22245519
02/2012

Childhood bullous pemphigoid: a rare manifestation of chronic renal allograft rejection.
Mammen C and White CT and Prendiville J
DOI: 10.1016/j.jaad.2010.02.034
PubMed: 21679824
07/2011

Standard Kt/V thresholds to accurately predict single-pool Kt/V targets for children receiving thrice-weekly maintenance haemodialysis.
Mammen C and Goldstein SL and Milner R and White CT
DOI: 10.1093/ndt/gfq165
PubMed: 20348543
09/2010

Research

Application of the Acute Kidney Injury Network (AKIN) Definition to Critically-Ill Children & Neonates.
A descriptive study analyzing AKI in the PICU at BC Children's Hospital from 2006-2008 through utilization of the AKIN definition with a direct comparison of the 3 severity classes of AKI (mild, moderate, severe) in terms of AKI etiologies, age, weight, risk of mortality scores, length of ICU stay, ventilation and other physiological parameters.

Small solute clearance in obese pediatric HD patients. White CT, Frankenfield, Goldstein SG, Mammen C, Neu AM.
A retrospective cohort study (2000-2008) utilizing data collected from the CMS ESRD Clinical Measures Project assessing the relationships between BMI and achievement of HD adequacy targets (spKt/V) through a logistic regression model.

Renal Outcomes of Acute Kidney Injury in the Pediatric ICU: A prospective cohort study
A longitudinal study to determine the incidence of chronic kidney disease (CKD) and to identify predictors of CKD in pediatric patients who have sustained Acute Kidney Injury (AKI) at BC Children's Hospital PICU from 2006-2008.

Grants

Title: Renal Outcomes Following Acute Kidney Injury in the Pediatric Intensive Care Unit: A Prospective Cohort Study. Granting Agency: Clinician Investigator Program, UBC. Salary Support: $65,000 x 2 yrs (2009-1010) Role: Principal Investigator.

Honours & Awards

Clinician Investigator Program (CIP), UBC, Vancouver, BC. (2009-2010) --- The aim of the CIP is to encourage young physicians to pursue careers as clinician scientists. Selection to this competitive, 2-year funded research fellowship program based on application including formal research grant proposal.

Research Group Members

Alex Roine, Co-op research student
Alice So, Division Administrative Supervisor