Overview

My research is primarily involved in the development, prevention and treatment of type 1 (insulin-dependent or juvenile-onset) diabetes.

I am an investigator in several multicenter clinical trials involved in preventing type 1 diabetes. In addition, I collaborate with basic-science researchers from the BC Research Institute and from the The Centre of Human Islet Transplant and Beta Cell Regeneration at VGH, helping provide clinical material (most commonly, blood samples) for their research.

I also maintain our Division's large website providing resources for families of children with diabetes and other endocrine disorders, and for the professionals caring for these patients.

Most recently, working with local and provincial resources, I have helped initiate an endocrine treatment program for transgendered youth.

Publications

Is Age a Risk Factor for Cerebral Edema in Children With Diabetic Ketoacidosis? A Literature Review
Canadian Journal of Diabetes
Glackin, S. and Metzger, D. and Hanas, R. and Chanoine, J.-P.
DOI: 10.1016/j.jcjd.2019.04.013
2020

Growth Hormone Supplementation and Psychosocial Functioning to Adult Height in Turner Syndrome: A Questionnaire Study of Participants in the Canadian Randomized Trial.
Frontiers in endocrinology
Rovet JF and Van Vliet G
DOI: 10.3389/fendo.2019.00125
PubMed: 30930850
03/2019

Skeletal muscle–specific activation of Gq signaling maintains glucose homeostasis
Diabetes
Bone, D.B.J. and Meister, J. and Knudsen, J.R. and Dattaroy, D. and Cohen, A. and Lee, R. and Lu, H. and Metzger, D. and Jensen, T.E. and Wess, J.
DOI: 10.2337/db18-0796
2019

Aging exacerbates ischemia-reperfusion-induced mitochondrial respiration impairment in skeletal muscle
Antioxidants
Paradis, S. and Charles, A.-L. and Georg, I. and Goupilleau, F. and Meyer, A. and Kindo, M. and Laverny, G. and Metzger, D. and Geny, B.
DOI: 10.3390/antiox8060168
2019

Senescence controls prostatic neoplasia driven by Pten loss
Molecular and Cellular Oncology
Parisotto, M. and Grelet, E. and El Bizri, R. and Metzger, D.
DOI: 10.1080/23723556.2018.1511205
2019

PGC-1ß modulates statin-associated myotoxicity in mice.
Archives of toxicology
Singh F and Zoll J and Duthaler U and Charles AL and Panajatovic MV and Laverny G and McWilliams TG and Metzger D and Metzger D and Geny B and Krähenbühl S and Bouitbir J
DOI: 10.1007/s00204-018-2369-7
PubMed: 30511338
12/2018

Prevalence and Severity of High Blood Pressure Among Children Based on the 2017 American Academy of Pediatrics Guidelines
JAMA Pediatrics
Atul K. Sharma and Daniel L. Metzger and Celia J. Rodd
DOI: 10.1001/jamapediatrics.2018.0223
06/2018

Glucose control and autonomic response during acute stress in youth with type 1 diabetes: A pilot study.
Pediatric diabetes
Guan L and Metzger DL and Lavoie PM and Collet JP
DOI: 10.1111/pedi.12680
PubMed: 29654713
05/2018

Effect of Hydrolyzed Infant Formula vs Conventional Formula on Risk of Type 1 Diabetes: The TRIGR Randomized Clinical Trial.
JAMA
Writing Group for the TRIGR Study Group and Knip M and Åkerblom HK and Al Taji E and Becker D and Bruining J and Castano L and Danne T and de Beaufort C and Dosch HM and Dupre J and Wasikowa R
DOI: 10.1001/jama.2017.19826
PubMed: 29297078
01/2018

Ligand-Independent Actions of Vitamin D Receptor
Vitamin D: Fourth Edition
Laverny, G. and Metzger, D.
DOI: 10.1016/B978-0-12-809965-0.00012-4
2018

How to limit the progression of PTEN-deficient prostatic tumors?,Comment limiter la progression des tumeurs prostatiques déficientes en PTEN ?
Medecine/Sciences
Grelet, E. and Parisotto, M. and Metzger, D.
DOI: 10.1051/medsci/2018224
2018

¿-Secretase Inhibition Lowers Plasma Triglyceride-Rich Lipoproteins by Stabilizing the LDL Receptor
Cell Metabolism
Kim, K. and Goldberg, I.J. and Graham, M.J. and Sundaram, M. and Bertaggia, E. and Lee, S.X. and Qiang, L. and Haeusler, R.A. and Metzger, D. and Chambon, P. and Yao, Z. and Ginsberg, H.N. and Pajvani, U.B.
DOI: 10.1016/j.cmet.2018.02.010
2018

Adherence to a pediatric diabetic ketoacidosis protocol in children presenting to a tertiary care hospital
Pediatric Diabetes
Ronsley, R. and Islam, N. and Ronsley, C. and Metzger, D.L. and Panagiotopoulos, C.
DOI: 10.1111/pedi.12556
2018

PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo
Journal of Experimental Medicine
Parisotto, M. and Grelet, E. and Bizri, R.E. and Dai, Y. and Terzic, J. and Eckert, D. and Gargowitsch, L. and Bornert, J.-M. and Metzger, D.
DOI: 10.1084/jem.20171207
2018

Short-Term Fasting Reveals Amino Acid Metabolism as a Major Sex-Discriminating Factor in the Liver
Cell Metabolism
Della Torre, S. and Mitro, N. and Meda, C. and Lolli, F. and Pedretti, S. and Barcella, M. and Ottobrini, L. and Metzger, D. and Caruso, D. and Maggi, A.
DOI: 10.1016/j.cmet.2018.05.021
2018

WHO height charts can be safely substituted when calculating BP Z-scores in a North American clinic setting
Paediatrics and Child Health (Canada)
Rodd, C.J. and Metzger, D.L. and Sharma, A.K.
DOI: 10.1093/pch/pxx185
2018

Diabetes worsens skeletal muscle mitochondrial function, oxidative stress, and apoptosis after lower-limb ischemia-reperfusion: Implication of the RISK and SAFE Pathways?
Frontiers in Physiology
Pottecher, J. and Adamopoulos, C. and Lejay, A. and Bouitbir, J. and Charles, A.-L. and Meyer, A. and Singer, M. and Wolff, V. and Diemunsch, P. and Laverny, G. and Metzger, D. and Geny, B.
DOI: 10.3389/fphys.2018.00579
2018

BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease.
Nature communications
Vieira JM and Howard S and Villa Del Campo C and Bollini S and Dubé KN and Masters M and Barnette DN and Rohling M and Sun X and Hankins LE and Gavriouchkina D and Williams R and Riley PR
DOI: 10.1038/ncomms16034
PubMed: 28737171
07/2017

Regional differences in milk and complementary feeding patterns in infants participating in an international nutritional type 1 diabetes prevention trial
Maternal & Child Nutrition
DOI: 10.1111/mcn.12354
07/2017

IFN-ß-induced reactive oxygen species and mitochondrial damage contribute to muscle impairment and inflammation maintenance in dermatomyositis.
Acta neuropathologica
Meyer A and Laverny G and Allenbach Y and Grelet E and Ueberschlag V and Echaniz-Laguna A and Lannes B and Alsaleh G and Charles AL and Singh F and Zoll J and Lonsdorfer E and Geny B
DOI: 10.1007/s00401-017-1731-9
PubMed: 28623559
06/2017

Hypogonadotropic Hypogonadism in Males with Glycogen Storage Disease Type 1.
JIMD reports
DOI: 10.1007/8904_2016_38
PubMed: 28160246
02/2017

Regeneration of fat cells from myofibroblasts during wound healing
Science
DOI: 10.1126/science.aai8792
02/2017

Re: Young adult patients with diabetes presenting to a university health clinic with depression and anxiety
British Columbia Medical Journal
Metzger, D.L.
2017

Nur77 deletion impairs muscle growth during developmental myogenesis and muscle regeneration in mice
PLoS ONE
Cortez-Toledo, O. and Schnair, C. and Sangngern, P. and Metzger, D. and ChaoThe, L.C.
DOI: 10.1371/journal.pone.0171268
2017

Gonad-related factors promote muscle performance gain during postnatal development in male and female mice
American Journal of Physiology - Endocrinology and Metabolism
Ueberschlag-Pitiot, V. and Stantzou, A. and Messéant, J. and Lemaitre, M. and Owens, D.J. and Noirez, P. and Roy, P. and Agbulut, O. and Metzger, D. and Ferry, A.
DOI: 10.1152/ajpendo.00446.2016
2017

Conditional expression of Ki-RasG12V in the mammary epithelium of transgenic mice induces estrogen receptor alpha (ERa)-positive adenocarcinoma
Oncogene
Andò, S. and Malivindi, R. and Catalano, S. and Rizza, P. and Barone, I. and Panza, S. and Rovito, D. and Emprou, C. and Bornert, J.-M. and Laverny, G. and Metzger, D.
DOI: 10.1038/onc.2017.252
2017

Improved protocol for chromatin immunoprecipitation from mouse skeletal muscle
Journal of Visualized Experiments
Joshi, S. and Ueberschlag-Pitiot, V. and Metzger, D. and Davidson, I.
DOI: 10.3791/56504
2017

Androgen signaling negatively controls group 2 innate lymphoid cells
Journal of Experimental Medicine
Laffont, S. and Blanquart, E. and Savignac, M. and Cénac, C. and Laverny, G. and Metzger, D. and Girard, J.-P. and Belz, G.T. and Pelletier, L. and Seillet, C. and Guéry, J.-C.
DOI: 10.1084/jem.20161807
2017

Peroxisome proliferator-activated receptor gamma (PPAR¿) regulates lactase expression and activity in the gut
EMBO Molecular Medicine
Fumery, M. and Speca, S. and Langlois, A. and Davila, A.-M. and Dubuquoy, C. and Grauso, M. and Martin Mena, A. and Figeac, M. and Metzger, D. and Rousseaux, C. and Colombel, J.-F. and Dubuquoy, L. and Desreumaux, P. and Bertin, B.
DOI: 10.15252/emmm.201707795
2017

The histone code reader Spin1 controls skeletal muscle development
Cell Death and Disease
Greschik, H. and Duteil, D. and Messaddeq, N. and Willmann, D. and Arrigoni, L. and Sum, M. and Jung, M. and Metzger, D. and Manke, T. and Günther, T. and Schüle, R.
DOI: 10.1038/cddis.2017.468
2017

Moderate exercise allows for shorter recovery time in critical limb ischemia
Frontiers in Physiology
Lejay, A. and Laverny, G. and Paradis, S. and Schlagowski, A.-I. and Charles, A.-L. and Singh, F. and Zoll, J. and Thaveau, F. and Lonsdorfer, E. and Dufour, S. and Favret, F. and Wolff, V. and Metzger, D. and Chakfe, N. and Geny, B.
DOI: 10.3389/fphys.2017.00523
2017

The nuclear receptor Nr4a1 acts as a microglia rheostat and serves as a therapeutic target in autoimmune-driven central nervous system inflammation
Journal of Immunology
Rothe, T. and Ipseiz, N. and Faas, M. and Lang, S. and Perez-Branguli, F. and Metzger, D. and Ichinose, H. and Winner, B. and Schett, G. and Krönke, G.
DOI: 10.4049/jimmunol.1600638
2017

Exome Sequencing and the Management of Neurometabolic Disorders.
The New England journal of medicine
Tarailo-Graovac M and Shyr C and Ross CJ and Horvath GA and Salvarinova R and Ye XC and Zhang LH and Bhavsar AP and Lee JJ and Drögemöller BI and Abdelsayed M and Alfadhel M and van Karnebeek CD
DOI: 10.1056/nejmoa1515792
PubMed: 27276562
05/2016

Somatic mosaicism underlies X-linked acrogigantism syndrome in sporadic male subjects.
Endocrine-related cancer
Daly AF and Yuan B and Fina F and Caberg JH and Trivellin G and Rostomyan L and de Herder WW and Naves LA and Metzger D and Cuny T and Rabl W and Shah N and Jaffrain-Rea ML and Zatelli MC and Beckers A
DOI: 10.1530/erc-16-0082
PubMed: 26935837
03/2016

PGC-1beta, an essential transcriptional coregulator of the skeletal muscle,PQC-1ß, un corégulateur trasoiptionnel essentiel du muscle squelettique
Biofutur
Laverny, G. and Metzger, D.
2016

Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis
Journal of Clinical Investigation
Xie, T. and Liang, J. and Liu, N. and Huan, C. and Zhang, Y. and Liu, W. and Kumar, M. and Xiao, R. and D'Armiento, J. and Metzger, D. and Chambon, P. and Papaioannou, V.E. and Stripp, B.R. and Jiang, D. and Noble, P.W.
DOI: 10.1172/JCI85328
2016

SOX4 is essential for prostate tumorigenesis initiated by PTEN ablation
Cancer Research
Bilir, B. and Osunkoya, A.O. and Wiles, W.G. and Sannigrahi, S. and Lefebvre, V. and Metzger, D. and Spyropoulos, D.D. and Martin, W.D. and Moreno, C.S.
DOI: 10.1158/0008-5472.CAN-15-1868
2016

Muscle expression of a malonyl-CoA-insensitive carnitine palmitoyltransferase-1 protects mice against high-fat/high-sucrose diet-induced insulin resistance
American journal of physiology. Endocrinology and metabolism
Vavrova, E. and Lenoir, V. and Alves-Guerra, M.-C. and Denis, R.G. and Castel, J. and Esnous, C. and Dyck, J.R. and Luquet, S. and Metzger, D. and Bouillaud, F. and Prip-Buus, C.
DOI: 10.1152/ajpendo.00020.2016
2016

LMS tables for waist-circumference and waist-height ratio Z-scores in children aged 5-19 y in NHANES III: association with cardio-metabolic risks.
Pediatric research
DOI: 10.1038/pr.2015.160
PubMed: 26331767
12/2015

Use of growth charts in Canada: A National Canadian Paediatric Surveillance Program survey.
Paediatrics & child health
DOI: 10.1093/pch/20.4.185
PubMed: 26038634
05/2015

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.
Nature genetics
Onengut-Gumuscu S and Chen WM and Burren O and Cooper NJ and Quinlan AR and Mychaleckyj JC and Farber E and Bonnie JK and Szpak M and Schofield E and Achuthan P and Guo H and Rich SS
DOI: 10.1038/ng.3245
PubMed: 25751624
03/2015

X-linked acrogigantism syndrome: clinical profile and therapeutic responses.
Endocrine-related cancer
Beckers A and Lodish MB and Trivellin G and Rostomyan L and Lee M and Faucz FR and Yuan B and Choong CS and Caberg JH and Verrua E and Naves LA and Cheetham TD and Young J and Lysy PA and Stratakis CA
DOI: 10.1530/erc-15-0038
PubMed: 25712922
02/2015

Orphan nuclear receptor NR4A1 regulates transforming growth factor-ß signaling and fibrosis.
Nature medicine
Palumbo-Zerr K and Zerr P and Distler A and Fliehr J and Mancuso R and Huang J and Mielenz D and Tomcik M and Fürnrohr BG and Scholtysek C and Dees C and Beyer C and Krönke G and Distler JH
DOI: 10.1038/nm.3777
PubMed: 25581517
01/2015

Managing type 1 diabetes in school: Recommendations for policy and practice.
Paediatrics & child health
PubMed: 25722642
2015

Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling
Journal of Clinical Investigation
Menéndez-Gutiérrez, M.P. and Rõszer, T. and Fuentes, L. and NÚnez, V. and Escolano, A. and Redondo, J.M. and De Clerck, N. and Metzger, D. and Valledor, A.F. and Ricote, M.
DOI: 10.1172/JCI77186
2015

A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects
Cell Reports
Huet, T. and Laverny, G. and Ciesielski, F. and Molnár, F. and Ramamoorthy, T.G. and Belorusova, A.Y. and Antony, P. and Potier, N. and Metzger, D. and Moras, D. and Rochel, N.
DOI: 10.1016/j.celrep.2014.12.045
2015

Managing type 1 diabetes in school: Recommendations for policy and practice
Paediatrics and Child Health (Canada)
Lawrence, S.E. and Cummings, E.A. and Pacaud, D. and Lynk, A. and Metzger, D.L.
DOI: 10.1093/pch/20.1.35
2015

The transcriptional coregulator PGC-1ß controls mitochondrial function and anti-oxidant defence in skeletal muscles
Nature Communications
Ramamoorthy, T.G. and Laverny, G. and Schlagowski, A.-I. and Zoll, J. and Messaddeq, N. and Bornert, J.-M. and Panza, S. and Ferry, A. and Geny, B. and Metzger, D.
DOI: 10.1038/ncomms10210
2015

Managing type 1 diabetes in school: Recommendations for policy and practice,Prise en charge du diabète de type 1 à l'école : Recommandations de politiques et de pratiques
Paediatrics and Child Health (Canada)
Lawrence, S.E. and Cummings, E.A. and Pacaud, D. and Lynk, A. and Metzger, D.L.
DOI: 10.1093/pch/20.1.40
2015

The orphan nuclear receptor Nur77 Is a determinant of myofiber size and muscle mass in mice
Molecular and Cellular Biology
Tontonoz, P. and Cortez-Toledo, O. and Wroblewski, K. and Hong, C. and Lim, L. and Carranza, R. and Conneely, O. and Metzger, D. and Chao, L.C.
DOI: 10.1128/MCB.00715-14
2015

Patrolling monocytes control tumor metastasis to the lung
Science
Hanna, R.N. and Cekic, C. and Sag, D. and Tacke, R. and Thomas, G.D. and Nowyhed, H. and Herrley, E. and Rasquinha, N. and McArdle, S. and Wu, R. and Peluso, E. and Metzger, D. and Ichinose, H. and Shaked, I. and Chodaczek, G. and Biswas, S.K. and Hedrick, C.C.
DOI: 10.1126/science.aac9407
2015

VDR and gemini ligands
Oncotarget
Laverny, G. and Metzger, D.
DOI: 10.18632/oncotarget.5446
2015

A new murine model of sustainable and durable chronic critical limb ischemia fairly mimicking human pathology
European Journal of Vascular and Endovascular Surgery
Lejay, A. and Choquet, P. and Thaveau, F. and Singh, F. and Schlagowski, A. and Charles, A.-L. and Laverny, G. and Metzger, D. and Zoll, J. and Chakfe, N. and Geny, B.
DOI: 10.1016/j.ejvs.2014.12.010
2015

Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation.
The New England journal of medicine
Trivellin G and Daly AF and Faucz FR and Yuan B and Rostomyan L and Larco DO and Schernthaner-Reiter MH and Szarek E and Leal LF and Caberg JH and Castermans E and Villa C and Stratakis CA
DOI: 10.1056/nejmoa1408028
PubMed: 25470569
12/2014

Autosomal dominant hypoparathyroidism caused by germline mutation in GNA11: phenotypic and molecular characterization.
The Journal of clinical endocrinology and metabolism
DOI: 10.1210/jc.2014-1029
PubMed: 24823460
09/2014

Hydrolyzed infant formula and early ß-cell autoimmunity: a randomized clinical trial.
JAMA
DOI: 10.1001/jama.2014.5610
PubMed: 24915259
06/2014

Clinical management of youth with gender dysphoria in Vancouver.
The Journal of pediatrics
DOI: 10.1016/j.jpeds.2013.10.068
PubMed: 24315505
04/2014

Provincial disparities of growth hormone coverage for young adult survivors of paediatric brain tumours across Canada.
Healthcare Policy
PubMed: 24726076
02/2014

B7-H4 expression in normal and diseased human islet ß cells.
Pancreas
DOI: 10.1097/mpa.0b013e31829695d2
PubMed: 24326367
01/2014

Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells.
Nature communications
Zhu D and Hölz S and Metzger E and Pavlovic M and Jandausch A and Jilg C and Galgoczy P and Herz C and Moser M and Metzger D and Günther T and Arnold SJ and Schüle R
DOI: 10.1038/ncomms4174
PubMed: 24448552
01/2014

Extending World Health Organization weight-for-age reference curves to older children.
BMC pediatrics
DOI: 10.1186/1471-2431-14-32
PubMed: 24490896
2014

Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type
Developmental Cell
Rahmani, W. and Abbasi, S. and Hagner, A. and Raharjo, E. and Kumar, R. and Hotta, A. and Magness, S. and Metzger, D. and Biernaskie, J.
DOI: 10.1016/j.devcel.2014.10.022
2014

Nurr1 expression is regulated by voltage-dependent calcium channels and calcineurin in cultured hippocampal neurons
Neuroscience Letters
Tokuoka, H. and Hatanaka, T. and Metzger, D. and Ichinose, H.
DOI: 10.1016/j.neulet.2013.11.033
2014

Brg1 Loss Attenuates Aberrant Wnt-Signalling and Prevents Wnt-Dependent Tumourigenesis in the Murine Small Intestine
PLoS Genetics
Holik, A.Z. and Young, M. and Krzystyniak, J. and Williams, G.T. and Metzger, D. and Shorning, B.Y. and Clarke, A.R.
DOI: 10.1371/journal.pgen.1004453
2014

Acute effect of androgens on maximal force-generating capacity and electrically evoked calcium transient in mouse skeletal muscles
Steroids
Fraysse, B. and Vignaud, A. and Fane, B. and Schuh, M. and Butler-Browne, G. and Metzger, D. and Ferry, A.
DOI: 10.1016/j.steroids.2014.05.005
2014

Provincial disparities of growth hormone coverage for young adult survivors of paediatric brain tumours across Canada
Healthcare Policy
Hasan, H. and Howard, F. and Morgan, S.G. and Metzger, D.L. and Lo, A.C. and Goddard, K. and Gill, S. and Johnson, M.
DOI: 10.12927/hcpol.2014.23728
2014

LSD1 promotes oxidative metabolism of white adipose tissue
Nature Communications
Duteil, D. and Metzger, E. and Willmann, D. and Karagianni, P. and Friedrichs, N. and Greschik, H. and Günther, T. and Buettner, R. and Talianidis, I. and Metzger, D. and Schüle, R.
DOI: 10.1038/ncomms5093
2014

Skeletal myofiber VEGF is essential for the exercise training response in adult mice
American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Delavar, H. and Nogueira, L. and Wagner, P.D. and Hogan, M.C. and Metzger, D. and Breen, E.C.
DOI: 10.1152/ajpregu.00522.2013
2014

B7-H4 expression in normal and diseased human islet ß Cells
Pancreas
Cheung, S.S.C. and Ou, D. and Metzger, D.L. and Meloche, M. and Ao, Z. and Ng, S.S.W. and Owen, D. and Warnock, G.L.
DOI: 10.1097/MPA.0b013e31829695d2
2014

Clearance of PML/RARA-bound promoters suffice to initiate APL differentiation
Blood
Vitaliano-Prunier, A. and Halftermeyer, J. and Ablain, J. and De Reynies, A. and Peres, L. and Le Bras, M. and Metzger, D. and De Thé, H.
DOI: 10.1182/blood-2014-03-561852
2014

Mammary stem cells have myoepithelial cell properties
Nature Cell Biology
Prater, M.D. and Petit, V. and Alasdair Russell, I. and Giraddi, R.R. and Shehata, M. and Menon, S. and Schulte, R. and Kalajzic, I. and Rath, N. and Olson, M.F. and Metzger, D. and Faraldo, M.M. and Deugnier, M.-A. and Glukhova, M.A. and Stingl, J.
DOI: 10.1038/ncb3025
2014

Myofiber androgen receptor promotes maximal mechanical overload-induced muscle hypertrophy and fiber type transition in male mice
Endocrinology
Ferry, A. and Schuh, M. and Parlakian, A. and Mgrditchian, T. and Valnaud, N. and Joanne, P. and Butler-Browne, G. and Agbulut, O. and Metzger, D.
DOI: 10.1210/en.2014-1195
2014

Canadian endocrinologists' views on growth hormone replacement therapy in adult survivors of pediatric brain tumors following achievement of final height
British Columbia Medical Journal
Hasan, H. and Fuchsia Howard, A. and Metzger, D.L. and Gill, S. and Johnson, M. and Lo, A.C. and Goddard, K.
2014

Canadian endocrinologists’ views on growth hormone replacement therapy in adult survivors of pediatric brain tumours following achievement of final height
BC Medical Journal
2014

Canadian Pediatric Endocrine Group extension to WHO growth charts: Why bother?
Paediatrics & child health
PubMed: 24421695
06/2013

Case 2: Pimples in prepuberty: A five-year-old with an unusual cause of facial comedones.
Paediatrics & child health
DOI: 10.1093/pch/18.2.91a
PubMed: 24421664
02/2013

Endogenous expression of B7-H4 improves long-term murine islet allograft survival.
Transplantation
DOI: 10.1097/tp.0b013e318277229d
PubMed: 23192157
01/2013

Occurrence of slipped capital femoral epiphysis in children undergoing gonadotropin-releasing hormone agonist therapy for the treatment of central precocious puberty.
Hormone research in paediatrics
DOI: 10.1159/000351028
PubMed: 23859950
2013

Canadian Pediatric Endocrine Group extension to WHO growth charts: Why bother?
Paediatrics and Child Health (Canada)
Lawrence, S. and Cummings, E. and Chanoine, J.-P. and Metzger, D.L. and Palmert, M. and Sharma, A. and Rodd, C.
DOI: 10.1093/pch/18.6.295
PubMed: 24421695
2013

Genetically engineered mouse models of prostate cancer
Molecular Oncology
Parisotto, M. and Metzger, D.
DOI: 10.1016/j.molonc.2013.02.005
2013

Knockdown of parathyroid hormone related protein in smooth muscle cells alters renal hemodynamics but not blood pressure
American Journal of Physiology - Renal Physiology
Raison, D. and Coquard, C. and Hochane, M. and Steger, J. and Massfelder, T. and Moulin, B. and Karaplis, A.C. and Metzger, D. and Chambon, P. and Helwig, J.-J. and Barthelmebs, M.
DOI: 10.1152/ajprenal.00503.2012
2013

Retinoid signaling in progenitors controls specification and regeneration of the urothelium
Developmental Cell
Gandhi, D. and Molotkov, A. and Batourina, E. and Schneider, K. and Dan, H. and Reiley, M. and Laufer, E. and Metzger, D. and Liang, F. and Liao, Y. and Sun, T.-T. and Aronow, B. and Rosen, R. and Mauney, J. and Adam, R. and Rosselot, C. and VanBatavia, J. and McMahon, A. and McMahon, J. and Guo, J.-J. and Mendelsohn, C.
DOI: 10.1016/j.devcel.2013.07.017
2013

Vitamin D receptor in osteoblasts is a negative regulator of bone mass control
Endocrinology
Yamamoto, Y. and Yoshizawa, T. and Fukuda, T. and Shirode-Fukuda, Y. and Yu, T. and Sekine, K. and Sato, T. and Sato, H.K. and Aihara, K.-I. and Nakamichi, Y. and Watanabe, T. and Shindo, M. and Inoue, K. and Inoue, E. and Tsuji, N. and Hoshino, M. and Karsenty, G. and Metzger, D. and Chambon, P. and Kato, S. and Imai, Y.
DOI: 10.1210/en.2012-1542
2013

Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis
Nature Immunology
Sekiya, T. and Kashiwagi, I. and Yoshida, R. and Fukaya, T. and Morita, R. and Kimura, A. and Ichinose, H. and Metzger, D. and Chambon, P. and Yoshimura, A.
DOI: 10.1038/ni.2520
2013

The BAF complex interacts with Pax6 in adult neural progenitors to establish a neurogenic cross-regulatory transcriptional network
Cell Stem Cell
Ninkovic, J. and Steiner-Mezzadri, A. and Jawerka, M. and Akinci, U. and Masserdotti, G. and Petricca, S. and Fischer, J. and Von Holst, A. and Beckers, J. and Lie, C.D. and Petrik, D. and Miller, E. and Tang, J. and Wu, J. and Lefebvre, V. and Demmers, J. and Eisch, A. and Metzger, D. and Crabtree, G. and Irmler, M. and Poot, R. and Götz, M.
DOI: 10.1016/j.stem.2013.07.002
2013

Prokineticin receptor 1 as a novel suppressor of preadipocyte proliferation and differentiation to control obesity
PLoS ONE
Szatkowski, C. and Vallet, J. and Dormishian, M. and Messaddeq, N. and Valet, P. and Boulberdaa, M. and Metzger, D. and Chambon, P. and Nebigil, C.G.
DOI: 10.1371/journal.pone.0081175
2013

Smoothened is a master regulator of adult liver repair
Journal of Clinical Investigation
Michelotti, G.A. and Xie, G. and Swiderska, M. and Choi, S.S. and Karaca, G. and Krüger, L. and Premont, R. and Yang, L. and Syn, W.-K. and Metzger, D. and Diehl, A.M.
DOI: 10.1172/JCI66904
2013

Skeletal muscle mitochondrial dysfunction precedes right ventricular impairment in experimental pulmonary hypertension
Molecular and Cellular Biochemistry
Enache, I. and Charles, A.-L. and Bouitbir, J. and Favret, F. and Zoll, J. and Metzger, D. and Oswald-Mammosser, M. and Geny, B. and Charloux, A.
DOI: 10.1007/s11010-012-1485-6
2013

Endogenous expression of B7-H4 improves long-term murine islet allograft survival
Transplantation
Wang, X. and Hao, J. and Metzger, D.L. and Mui, A. and Lee, I.-F. and Akhoundsadegh, N. and Ao, Z. and Chen, L. and Ou, D. and Verchere, C.B. and Warnock, G.L.
DOI: 10.1097/TP.0b013e318277229d
2013

Polyphenols prevent ageing-related impairment in skeletal muscle mitochondrial function through decreased reactive oxygen species production
Experimental Physiology
Charles, A.-L. and Meyer, A. and Dal-Ros, S. and Auger, C. and Keller, N. and Ramamoorthy, T.G. and Zoll, J. and Metzger, D. and Schini-Kerth, V. and Geny, B.
DOI: 10.1113/expphysiol.2012.067496
2013

Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue.
Molecular and cellular biology
Nadra K and Médard JJ and Mul JD and Han GS and Grès S and Pende M and Metzger D and Metzger D and Chambon P and Cuppen E and Saulnier-Blache JS and Carman GM and Desvergne B and Chrast R
DOI: 10.1128/mcb.00512-12
PubMed: 23028044
10/2012

When genetic load does not correlate with phenotypic spectrum: lessons from the GnRH receptor (GNRHR).
The Journal of clinical endocrinology and metabolism
DOI: 10.1210/jc.2012-1264
PubMed: 22745237
09/2012

Relevance of exocytotic glutamate release from retinal glia.
Neuron
Slezak M and Grosche A and Niemiec A and Tanimoto N and Pannicke T and Münch TA and Crocker B and Isope P and Härtig W and Beck SC and Huber G and Ferracci G and Perraut M and Reber M and Pfrieger FW
DOI: 10.1016/j.neuron.2012.03.027
PubMed: 22578502
05/2012

Blockade of both B7-H4 and CTLA-4 co-signaling pathways enhances mouse islet allograft survival.
Islets
DOI: 10.4161/isl.21239
PubMed: 22878670
2012

Chromatin-Remodeling Factor Brg1 Is Required for Schwann Cell Differentiation and Myelination
Developmental Cell
Weider, M. and Küspert, M. and Bischof, M. and Vogl, M.R. and Hornig, J. and Loy, K. and Kosian, T. and Müller, J. and Hillgärtner, S. and Tamm, E.R. and Metzger, D. and Wegner, M.
DOI: 10.1016/j.devcel.2012.05.017
2012

Temporally controlled targeted somatic mutagenesis in mouse eye pigment epithelium
Genesis
Mori, M. and Gargowitsch, L. and Bornert, J.-M. and Garnier, J.-M. and Mark, M. and Chambon, P. and Metzger, D.
DOI: 10.1002/dvg.22044
2012

Generation of transplantable beta cells for patient-specific cell therapy
International Journal of Endocrinology
Wang, X. and Metzger, D.L. and Meloche, M. and Hao, J. and Ao, Z. and Warnock, G.L.
DOI: 10.1155/2012/414812
2012

PPARß/d affects pancreatic ß cell mass and insulin secretion in mice
Journal of Clinical Investigation
Iglesias, J. and Barg, S. and Vallois, D. and Lahiri, S. and Roger, C. and Yessoufou, A. and Pradevand, S. and McDonald, A. and Bonal, C. and Reimann, F. and Gribble, F. and Debril, M.-B. and Metzger, D. and Chambon, P. and Herrera, P. and Rutter, G.A. and Prentki, M. and Thorens, B. and Wahli, W.
DOI: 10.1172/JCI42127
2012

B7-H4 induces donor-specific tolerance in mouse islet allografts
Cell Transplantation
Wang, X. and Hao, J. and Metzger, D.L. and Mui, A. and Ao, Z. and Bruce Verchere, C. and Chen, L. and Ou, D. and Warnock, G.L.
DOI: 10.3727/096368911X582750
2012

Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors
Nature Medicine
McCurley, A. and Pires, P.W. and Bender, S.B. and Aronovitz, M. and Zhao, M.J. and Metzger, D. and Chambon, P. and Hill, M.A. and Dorrance, A.M. and Mendelsohn, M.E. and Jaffe, I.Z.
DOI: 10.1038/nm.2891
2012

The nuclear hormone receptor PPAR¿ counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cells
Nature Communications
Woldt, E. and Terrand, J. and Mlih, M. and Matz, R.L. and Bruban, V. and Coudane, F. and Foppolo, S. and El Asmar, Z. and Chollet, M.E. and Ninio, E. and Bednarczyk, A. and Thiersé, D. and Schaeffer, C. and Van Dorsselaer, A. and Boudier, C. and Wahli, W. and Chambon, P. and Metzger, D. and Herz, J. and Boucher, P.
DOI: 10.1038/ncomms2087
2012

B7-H4 treatment of t cells inhibits erk, jnk, p38, and akt activation
PLoS ONE
Wang, X. and Hao, J. and Metzger, D.L. and Ao, Z. and Chen, L. and Ou, D. and Verchere, C.B. and Mui, A. and Warnock, G.L.
DOI: 10.1371/journal.pone.0028232
2012

B7-H4 induces donor-specific tolerance in mouse islet allografts.
Cell transplantation
DOI: 10.3727/096368912x633815
PubMed: 21929869
2012

Early treatment of NOD mice with B7-H4 reduces the incidence of autoimmune diabetes.
Diabetes
DOI: 10.2337/db11-0375
PubMed: 21984581
12/2011

Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry.
Nature genetics
Hunt KA and Smyth DJ and Balschun T and Ban M and Mistry V and Ahmad T and Anand V and Barrett JC and Bhaw-Rosun L and Bockett NA and Brand OJ and Brouwer E and Concannon P and Cooper JD and van Heel DA
DOI: 10.1038/ng.1037
PubMed: 22200769
12/2011

Novel use of F-DOPA PET/CT imaging in a child with paraganglioma/pheochromocytoma syndrome.
Pediatric radiology
DOI: 10.1007/s00247-011-2109-0
PubMed: 21567141
10/2011

Chromatin remodelling complex dosage modulates transcription factor function in heart development
Nature Communications
DOI: 10.1038/ncomms1187
09/2011

Validation of diabetes case definitions using administrative claims data.
Diabetic medicine : a journal of the British Diabetic Association
DOI: 10.1111/j.1464-5491.2011.03238.x
PubMed: 21392063
04/2011

B7-H4 Pathway in Islet Transplantation and ß-Cell Replacement Therapies.
Journal of transplantation
DOI: 10.1155/2011/418902
PubMed: 22028949
2011

Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection
Journal of Biological Chemistry
Tokuoka, H. and Muramatsu, S.-I. and Sumi-Ichinose, C. and Sakane, H. and Kojima, M. and Aso, Y. and Nomura, T. and Metzger, D. and Ichinose, H.
DOI: 10.1074/jbc.M111.284729
2011

Aggravated TSLP-induced atopic dermatitis in mice lacking Dicer in adult skin keratinocytes
Journal of Investigative Dermatology
Hener, P. and Friedmann, L. and Metzger, D. and Chambon, P. and Li, M.
DOI: 10.1038/jid.2011.208
2011

The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells
Nature Communications
Sekiya, T. and Kashiwagi, I. and Inoue, N. and Morita, R. and Hori, S. and Waldmann, H. and Rudensky, A.Y. and Ichinose, H. and Metzger, D. and Chambon, P. and Yoshimura, A.
DOI: 10.1038/ncomms1272
2011

Strict control of transgene expression in a mouse model for sensitive biological applications based on RMCE compatible ES cells
Nucleic Acids Research
Sandhu, U. and Cebula, M. and Behme, S. and Riemer, P. and Wodarczyk, C. and Metzger, D. and Reimann, J. and Schirmbeck, R. and Hauser, H. and Wirth, D.
DOI: 10.1093/nar/gkq868
2011

Noncanonical Wnt signaling mediates androgen-dependent tumor growth in a mouse model of prostate cancer
Proceedings of the National Academy of Sciences of the United States of America
Takahashi, S. and Watanabe, T. and Okada, M. and Inoue, K. and Ueda, T. and Takada, I. and Watabe, T. and Yamamoto, Y. and Fukuda, T. and Nakamura, T. and Akimoto, C. and Fujimura, T. and Hoshino, M. and Imai, Y. and Metzger, D. and Miyazono, K. and Minami, Y. and Chambon, P. and Kitamura, T. and Matsumoto, T. and Kato, S.
DOI: 10.1073/pnas.1014850108
2011

Hypoxia-inducible transcription factor 2a promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis
Hepatology
Qu, A. and Taylor, M. and Xue, X. and Matsubara, T. and Metzger, D. and Chambon, P. and Gonzalez, F.J. and Shah, Y.M.
DOI: 10.1002/hep.24400
2011

Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor
Cell
Surjit, M. and Ganti, K.P. and Mukherji, A. and Ye, T. and Hua, G. and Metzger, D. and Li, M. and Chambon, P.
DOI: 10.1016/j.cell.2011.03.027
2011

Regenerated luminal epithelial cells are derived from preexisting luminal epithelial cells in adult mouse prostate
Molecular Endocrinology
Liu, J. and Pascal, L.E. and Isharwal, S. and Metzger, D. and Garcia, R.R. and Pilch, J. and Kasper, S. and Williams, K. and Basse, P.H. and Nelson, J.B. and Chambon, P. and Wang, Z.
DOI: 10.1210/me.2011-1081
2011

SWI/SNF complexes containing brahma Brahma-related gene 1 play distinct roles in smooth muscle development
Molecular and Cellular Biology
Zhang, M. and Chen, M. and Kim, J.-R. and Zhou, J. and Jones, R.E. and Tune, J.D. and Kassab, G.S. and Metzger, D. and Ahlfeld, S. and Conway, S.J. and Herring, B.P.
DOI: 10.1128/MCB.01338-10
2011

Designing and implementing sample and data collection for an international genetics study: the Type 1 Diabetes Genetics Consortium (T1DGC).
Clinical trials (London, England)
Hilner JE and Perdue LH and Sides EG and Pierce JJ and Wägner AM and Aldrich A and Loth A and Albret L and Wagenknecht LE and Nierras C and Akolkar B and T1DGC
DOI: 10.1177/1740774510373497
PubMed: 20603248
07/2010

Methylation profiling in individuals with Russell-Silver syndrome.
American journal of medical genetics. Part A
DOI: 10.1002/ajmg.a.33204
PubMed: 20082469
02/2010

Diabetic ketoacidosis in children and adolescents: an update and revised treatment protocol
BC Medical Journal
2010

The transcriptional coregulators TIF2 and SRC-1 regulate energy homeostasis by modulating mitochondrial respiration in skeletal muscles
Cell Metabolism
Duteil, D. and Chambon, C. and Ali, F. and Malivindi, R. and Zoll, J. and Kato, S. and Geny, B. and Chambon, P. and Metzger, D.
DOI: 10.1016/j.cmet.2010.09.016
2010

Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation
Epigenetics and Chromatin
He, S. and Pirity, M.K. and Wang, W.-L. and Wolf, L. and Chauhan, B.K. and Cveklova, K. and Tamm, E.R. and Ashery-Padan, R. and Metzger, D. and Nakai, A. and Chambon, P. and Zavadil, J. and Cvekl, A.
DOI: 10.1186/1756-8935-3-21
2010

Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy
Journal of Biological Chemistry
Cheng, L. and Guo, J. and Sun, L. and Fu, J. and Barnes, P.F. and Metzger, D. and Chambon, P. and Oshima, R.G. and Amagai, T. and Su, D.-M.
DOI: 10.1074/jbc.M109.072124
2010

Myocytic androgen receptor controls the strength but not the mass of limb muscles
Proceedings of the National Academy of Sciences of the United States of America
Chambon, C. and Duteil, D. and Vignaud, A. and Ferry, A. and Messaddeq, N. and Malivindi, R. and Kato, S. and Chambon, P. and Metzger, D.
DOI: 10.1073/pnas.1009536107
2010

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7
Oncogene
Rocher-Ros, V. and Marco, S. and Mao, J.-H. and Gines, S. and Metzger, D. and Chambon, P. and Balmain, A. and Saura, C.A.
DOI: 10.1038/onc.2010.57
2010

Inflammatory Mediator TAK1 Regulates Hair Follicle Morphogenesis And Anagen Induction Shown By Using Keratinocyte-Specific TAK1-Deficient Mice
PLoS ONE
Sayama, K. and Kajiya, K. and Sugawara, K. and Sato, S. and Hirakawa, S. and Shirakata, Y. and Hanakawa, Y. and Dai, X. and Ishimatsu-Tsuji, Y. and Metzger, D. and Chambon, P. and Akira, S. and Paus, R. and Kishimoto, J. and Hashimoto, K.
DOI: 10.1371/journal.pone.0011275
2010

Epidermal ¿d T cells sense precancerous cellular dysregulation and initiate immune responses
International Immunology
Shimura, E. and Hozumi, N. and Kanagawa, O. and Metzger, D. and Chambon, P. and Radtke, F. and Hirose, S. and Nakano, N.
DOI: 10.1093/intimm/dxq014
2010

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
Nature Genetics
DOI: 10.1038/ng.381
06/2009

Local expression of B7-H4 by recombinant adenovirus transduction in mouse islets prolongs allograft survival.
Transplantation
DOI: 10.1097/tp.0b013e318195e5fa
PubMed: 19307783
02/2009

Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis
Proceedings of the National Academy of Sciences of the United States of America
Golonzhka, O. and Metzger, D. and Bornert, J.-M. and Bay, B.K. and Gross, M.K. and Kioussi, C. and Leid, M.
DOI: 10.1073/pnas.0900568106
2009

Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent on activity of BRG1, the ATPase of the SWI/SNF chromatin remodeling complex
Cancer Research
Xi, W. and Sansam, C.G. and Thom, C.S. and Metzger, D. and Evans, J.A. and Nguyen, P.T.L. and Roberts, C.W.M.
DOI: 10.1158/0008-5472.CAN-09-0733
2009

SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity
Molecular Biology of the Cell
Bourgo, R.J. and Siddiqui, H. and Fox, S. and Solomon, D. and Sansam, C.G. and Yaniv, M. and Muchardt, C. and Metzger, D. and Chambon, P. and Roberts, C.W.M. and Knudsen, E.S.
DOI: 10.1091/mbc.E08-12-1224
2009

LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of wnt signaling
Journal of Biological Chemistry
Terrand, J. and Bruban, V. and Zhou, L. and Gong, W. and Asmar, Z.E. and May, P. and Zurhove, K. and Haffner, P. and Philippe, C. and Woldt, E. and Matz, R.L. and Gracia, C. and Metzger, D. and Auwerx, J. and Herz, J. and Boucher, P.
DOI: 10.1074/jbc.M806538200
2009

Induction of thymic stromal lymphopoietin expression in keratinocytes is necessary for generating an atopic dermatitis upon application of the active vitamin D3 analogue MC903 on mouse skin
Journal of Investigative Dermatology
Li, M. and Hener, P. and Zhang, Z. and Ganti, K.P. and Metzger, D. and Chambon, P.
DOI: 10.1038/jid.2008.232
2009

Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons
Journal of Neuroscience
Kadkhodaei, B. and Ito, T. and Joodmardi, E. and Mattsson, B. and Rouillard, C. and Carta, M. and Muramatsu, S.-I. and Sumi-Ichinose, C. and Nomura, T. and Metzger, D. and Chambon, P. and Lindqvist, E. and Larsson, N.-G. and Olson, L. and Björklund, A. and Ichinose, H. and Perlmann, T.
DOI: 10.1523/JNEUROSCI.3910-09.2009
2009

Autophagy Is Required to Maintain Muscle Mass
Cell Metabolism
Masiero, E. and Agatea, L. and Mammucari, C. and Blaauw, B. and Loro, E. and Komatsu, M. and Metzger, D. and Reggiani, C. and Schiaffino, S. and Sandri, M.
DOI: 10.1016/j.cmet.2009.10.008
2009

Efficient temporally-controlled targeted mutagenesis in smooth muscle cells of the adult mouse
Genesis
Wendling, O. and Bornert, J.-M. and Chambon, P. and Metzger, D.
DOI: 10.1002/dvg.20448
2009

Corneodesmosin gene ablation induces lethal skinbarrier disruption and hair-follicle degeneration related to desmosome dysfunction
Journal of Cell Science
Leclerc, E.A. and Huchenq, A. and Mattiuzzo, N.R. and Metzger, D. and Chambon, P. and Ghyselinck, N.B. and Serre, G. and Jonca, N. and Guerrin, M.
DOI: 10.1242/jcs.050302
2009

Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation
Journal of Investigative Dermatology
Golonzhka, O. and Liang, X. and Messaddeq, N. and Bornert, J.-M. and Campbell, A.L. and Metzger, D. and Chambon, P. and Ganguli-Indra, G. and Leid, M. and Indra, A.K.
DOI: 10.1038/jid.2008.392
2009

Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma
Proceedings of the National Academy of Sciences of the United States of America
Zhang, Z. and Hener, P. and Frossard, N. and Kato, S. and Metzger, D. and Li, M. and Chambon, P.
DOI: 10.1073/pnas.0812668106
2009

Local expression of B7-H4 by recombinant adenovirus transduction in mouse islets prolongs allograft survival
Transplantation
Wang, X. and Hao, J. and Metzger, D.L. and Mui, A. and Ao, Z. and Verchere, C.B. and Chen, L. and Ou, D. and Warnock, G.L.
DOI: 10.1097/TP.0b013e318195e5fa
2009

Twenty-one additional cases of familial renal glucosuria: absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
DOI: 10.1093/ndt/gfn386
PubMed: 18622023
12/2008

Abrogation of mitochondrial transcription in smooth muscle cells impairs smooth muscle contractility and vascular tone
Journal of Physiology and Pharmacology
Jawien, J. and Bian, Z. and Sheikine, Y. and Olofsson, P.S. and Pang, Y. and Edholm, T. and Dou, Y. and Metzger, D. and Hellström, P.M. and Feil, R. and Hansson, G.K.
2008

Targeted knockout of BRG1 potentiates lung cancer development
Cancer Research
Glaros, S. and Cirrincione, G.M. and Palanca, A. and Metzger, D. and Reisman, D.
DOI: 10.1158/0008-5472.CAN-07-6652
2008

Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma
Proceedings of the National Academy of Sciences of the United States of America
Ratnacaram, C.K. and Teletin, M. and Jiang, M. and Meng, X. and Chambon, P. and Metzger, D.
DOI: 10.1073/pnas.0712021105
2008

Premature aging in skeletal muscle lacking serum response factor
PLoS ONE
Lahoute, C. and Sotiropoulos, A. and Favier, M. and Guillet-Deniau, I. and Charvet, C. and Ferry, A. and Butler-Browne, G. and Metzger, D. and Tuil, D. and Daegelen, D.
DOI: 10.1371/journal.pone.0003910
2008

Expanded CTG repeats within the DMPK 3' UTR causes severe skeletal muscle wasting in an inducible mouse model for myotonic dystrophy
Proceedings of the National Academy of Sciences of the United States of America
Orengo, J.P. and Chambon, P. and Metzger, D. and Mosier, D.R. and Snipes, G.J. and Cooper, T.A.
DOI: 10.1073/pnas.0708519105
2008

Cutaneous cancer stem cell maintenance is dependent on ß-catenin signalling
Nature
Malanchi, I. and Peinado, H. and Kassen, D. and Hussenet, T. and Metzger, D. and Chambon, P. and Huber, M. and Hohl, D. and Cano, A. and Birchmeier, W. and Huelsken, J.
DOI: 10.1038/nature06835
2008

The TRIGR Trial: Testing the Potential Link between Weaning Diet and Type 1 Diabetes
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry
DOI: 10.2174/187152207780832315
06/2007

Study design of the Trial to Reduce IDDM in the Genetically at Risk (TRIGR)
Pediatric Diabetes
DOI: 10.1111/j.1399-5448.2007.00239.x
06/2007

IL-13 induces expression of CD36 in human monocytes through PPAR¿ activation
European Journal of Immunology
DOI: 10.1002/eji.200636625
06/2007

Skewed X-chromosome inactivation is associated with primary but not secondary ovarian failure.
American journal of medical genetics. Part A
DOI: 10.1002/ajmg.a.31679
PubMed: 17431892
05/2007

LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease
Proceedings of the National Academy of Sciences of the United States of America
Coste, A. and Dubuquoy, L. and Barnouin, R. and Annicotte, J.-S. and Magnier, B. and Notti, M. and Corazza, N. and Antal, M.C. and Metzger, D. and Desreumaux, P. and Brunner, T. and Auwerx, J. and Schoonjans, K.
DOI: 10.1073/pnas.0702440104
2007

Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor a in epidermal keratinocytes
Journal of Investigative Dermatology
Indra, A.K. and Castaneda, E. and Antal, M.C. and Jiang, M. and Messaddeq, N. and Meng, X. and Loehr, C.V. and Gariglio, P. and Kato, S. and Wahli, W. and Desvergne, B. and Metzger, D. and Chambon, P.
DOI: 10.1038/sj.jid.5700672
2007

Loss of Trim24 (Tif1a) gene function confers oncogenic activity to retinoic acid receptor alpha
Nature Genetics
Khetchoumian, K. and Teletin, M. and Tisserand, J. and Mark, M. and Herquel, B. and Ignat, M. and Zucman-Rossi, J. and Cammas, F. and Lerouge, T. and Thibault, C. and Metzger, D. and Chambon, P. and Losson, R.
DOI: 10.1038/ng.2007.15
2007

TGF-ß superfamily signaling is essential for tooth and hair morphogenesis and differentiation
European Journal of Cell Biology
Klopcic, B. and Maass, T. and Meyer, E. and Lehr, H.A. and Metzger, D. and Chambon, P. and Mann, A. and Blessing, M.
DOI: 10.1016/j.ejcb.2007.03.005
2007

Estrogen Prevents Bone Loss via Estrogen Receptor a and Induction of Fas Ligand in Osteoclasts
Cell
Nakamura, T. and Imai, Y. and Matsumoto, T. and Sato, S. and Takeuchi, K. and Igarashi, K. and Harada, Y. and Azuma, Y. and Krust, A. and Yamamoto, Y. and Nishina, H. and Takeda, S. and Takayanagi, H. and Metzger, D. and Kanno, J. and Takaoka, K. and Martin, T.J. and Chambon, P. and Kato, S.
DOI: 10.1016/j.cell.2007.07.025
2007

Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1
Molecular and Cellular Biology
Mataki, C. and Magnier, B.C. and Houten, S.M. and Annicotte, J.-S. and Argmann, C. and Thomas, C. and Overmars, H. and Kulik, W. and Metzger, D. and Auwerx, J. and Schoonjans, K.
DOI: 10.1128/MCB.00852-07
2007

Apoptotic extinction of germ cells in testes of Cyp26b1 knockout mice
Endocrinology
MacLean, G. and Li, H. and Metzger, D. and Chambon, P. and Petkovich, M.
DOI: 10.1210/en.2007-0492
2007

Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure
Proceedings of the National Academy of Sciences of the United States of America
Dali-Youcef, N. and Mataki, C. and Coste, A. and Messaddeq, N. and Giroud, S. and Blanc, S. and Koehl, C. and Champy, M.-F. and Chambon, P. and Fajas, L. and Metzger, D. and Schoonjans, K. and Auwerx, J.
DOI: 10.1073/pnas.0611568104
2007

The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis
Development
Fadloun, A. and Kobi, D. and Pointud, J.-C. and Indra, A.K. and Teletin, M. and Bole-Feysot, C. and Testoni, B. and Mantovani, R. and Metzger, D. and Mengus, G. and Davidson, I.
DOI: 10.1242/dev.005041
2007

Transgenic mice for conditional gene manipulation in astroglial cells
GLIA
Slezak, M. and Göritz, C. and Niemiec, A. and Frisén, J. and Chambon, P. and Metzger, D. and Pfrieger, F.W.
DOI: 10.1002/glia.20570
2007

Inducible Cre/loxP recombination in the mouse proximal tubule
Nephron - Experimental Nephrology
Dworniczak, B. and Skryabin, B. and Tchinda, J. and Heuck, S. and Seesing, F.-J. and Metzger, D. and Chambon, P. and Horst, J. and Pennekamp, P.
DOI: 10.1159/000100554
2007

Contribution of targeted conditional somatic mutagenesis to deciphering retinoid X receptor functions and to generating mouse models of human diseases
Handbook of Experimental Pharmacology
Metzger, D. and Chambon, P.
DOI: 10.1007/978-3-540-35109-2-21
2007

Autosomal dominant pseudohypoaldosteronism type 1: mechanisms, evidence for neonatal lethality, and phenotypic expression in adults.
Journal of the American Society of Nephrology : JASN
DOI: 10.1681/asn.2005111188
PubMed: 16611713
05/2006

Mutations in fibroblast growth factor receptor 1 cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism.
Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.0600962103
PubMed: 16606836
04/2006

Suppression of human T-cell responses to beta-cells by activation of B7-H4 pathway.
Cell transplantation
DOI: 10.3727/000000006783981837
PubMed: 28871868
2006

Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling
Human Molecular Genetics
Nenci, A. and Huth, M. and Funteh, A. and Schmidt-Supprian, M. and Bloch, W. and Metzger, D. and Chambon, P. and Rajewsky, K. and Krieg, T. and Haase, I. and Pasparakis, M.
DOI: 10.1093/hmg/ddi470
2006

Premature ovarian failure in androgen receptor-deficient mice
Proceedings of the National Academy of Sciences of the United States of America
Shiina, H. and Matsumoto, T. and Sato, T. and Igarashi, K. and Miyamoto, J. and Takemasa, S. and Sakari, M. and Takada, I. and Nakamura, T. and Metzger, D. and Chambon, P. and Kanno, J. and Yoshikawa, H. and Kato, S.
DOI: 10.1073/pnas.0506736102
2006

Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis
Proceedings of the National Academy of Sciences of the United States of America
Li, M. and Hener, P. and Zhang, Z. and Kato, S. and Metzger, D. and Chambon, P.
DOI: 10.1073/pnas.0604575103
2006

Localized inflammatory skin disease following inducible ablation of I kappa B kinase 2 in murine epidermis
Journal of Investigative Dermatology
Stratis, A. and Pasparakis, M. and Markur, D. and Knaup, R. and Pofahl, R. and Metzger, D. and Chambon, P. and Krieg, T. and Haase, I.
DOI: 10.1038/sj.jid.5700092
2006

PGC1a expression is controlled in skeletal muscles by PPARß, whose ablation results in fiber-type switching, obesity, and type 2 diabetes
Cell Metabolism
Schuler, M. and Ali, F. and Chambon, C. and Duteil, D. and Bornert, J.-M. and Tardivel, A. and Desvergne, B. and Wahli, W. and Chambon, P. and Metzger, D.
DOI: 10.1016/j.cmet.2006.10.003
2006

Viral-mediated temporally controlled dopamine production in a rat model of Parkinson disease
Molecular Therapy
Li, X.-G. and Okada, T. and Kodera, M. and Nara, Y. and Takino, N. and Muramatsu, C. and Ikeguchi, K. and Urano, F. and Ichinose, H. and Metzger, D. and Chambon, P. and Nakano, I. and Ozawa, K. and Muramatsu, S.-I.
DOI: 10.1016/j.ymthe.2005.08.009
2006

Autosomal dominant pseudohypoaldosteronism type 1: Mechanisms, evidence for neonatal lethality, and phenotypic expression in adults
Journal of the American Society of Nephrology
Geller, D.S. and Zhang, J. and Zennaro, M.-C. and Vallo-Boado, A. and Rodriguez-Soriano, J. and Furu, L. and Haws, R. and Metzger, D. and Botelho, B. and Karaviti, L. and Haqq, A.M. and Corey, H. and Janssens, S. and Corvol, P. and Lifton, R.P.
DOI: 10.1681/ASN.2005111188
2006

Skin epidermis lacking the c-myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21 Cip1 gene
Genes and Development
Oskarsson, T. and Essers, M.A.G. and Dubois, N. and Offner, S. and Dubey, C. and Roger, C. and Metzger, D. and Chambon, P. and Hummler, E. and Beard, P. and Trumpp, A.
DOI: 10.1101/gad.381206
2006

Brg1 is required for murine neural stem cell maintenance and gliogenesis
Developmental Biology
Matsumoto, S. and Banine, F. and Struve, J. and Xing, R. and Adams, C. and Liu, Y. and Metzger, D. and Chambon, P. and Rao, M.S. and Sherman, L.S.
DOI: 10.1016/j.ydbio.2005.10.044
2006

Temporal regulation of Cre recombinase activity in neural stem cells
Genesis
Imayoshi, I. and Ohtsuka, T. and Metzger, D. and Chambon, P. and Kageyama, R.
DOI: 10.1002/dvg.20212
2006

LPS-induced TNF-a factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways
Proceedings of the National Academy of Sciences of the United States of America
Tang, X. and Metzger, D. and Leeman, S. and Amar, S.
DOI: 10.1073/pnas.0605988103
2006

Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes
Genes and Development
Calléja, C. and Messaddeq, N. and Chapellier, B. and Yang, H. and Krezel, W. and Li, M. and Metzger, D. and Mascrez, B. and Ohta, K. and Kagechika, H. and Endo, Y. and Mark, M. and Ghyselinck, N.B. and Chambon, P.
DOI: 10.1101/gad.368706
2006

Conditional Knockouts: Cre-Lox Systems
Cell Biology, Four-Volume Set
Metzger, D. and Li, M. and Indra, A.K. and Schuler, M. and Chambon, P.
DOI: 10.1016/B978-012164730-8/50181-7
2006

Novel TRPM6 mutations in 21 families with primary hypomagnesemia and secondary hypocalcemia.
Journal of the American Society of Nephrology : JASN
DOI: 10.1681/asn.2004110989
PubMed: 16107578
10/2005

Regulation of TNF-related apoptosis-inducing ligand-mediated death-signal pathway in human beta cells by Fas-associated death domain and nuclear factor kappaB.
Human immunology
DOI: 10.1016/j.humimm.2005.03.009
PubMed: 16112027
07/2005

Autosomal dominant resistance to thyrotropin as a distinct entity in five multigenerational kindreds: clinical characterization and exclusion of candidate loci.
The Journal of clinical endocrinology and metabolism
DOI: 10.1210/jc.2005-0572
PubMed: 15870119
07/2005

Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial--Type 1.
Diabetes care
DOI: 10.2337/diacare.28.5.1068
PubMed: 15855569
05/2005

Synergistic inhibition of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human pancreatic beta cells by Bcl-2 and X-linked inhibitor of apoptosis.
Human immunology
DOI: 10.1016/j.humimm.2004.12.002
PubMed: 15784465
03/2005

Tumor necrosis factor-related apoptosis-inducing ligand and CD56 expression in patients with type 1 diabetes mellitus.
Pancreas
DOI: 10.1097/01.mpa.0000148515.77497.4b
PubMed: 15714132
03/2005

Oculorespiratory syndrome after influenza immunization in children.
The Pediatric infectious disease journal
DOI: 10.1097/01.inf.0000148924.89558.d5
PubMed: 15665712
01/2005

Targeted somatic mutagenesis in the mouse epidermis.
Methods in molecular biology (Clifton, N.J.)
Metzger, D. and Li, M. and Chambon, P.
2005

Functional role of RXRs and PPAR¿ in mature adipocytes
Prostaglandins Leukotrienes and Essential Fatty Acids
Metzger, D. and Imai, T. and Jiang, M. and Takukawa, R. and Desvergne, B. and Wahli, W. and Chambon, P.
DOI: 10.1016/j.plefa.2005.04.007
2005

Disturbed epidermal structure in mice with temporally controlled Fatp4 deficiency
Journal of Investigative Dermatology
Herrmann, T. and Gröne, H.-J. and Langbein, L. and Kaiser, I. and Gosch, I. and Bennemann, U. and Metzger, D. and Chambon, P. and Stewart, A.F. and Stremmel, W.
DOI: 10.1111/j.0022-202X.2005.23972.x
2005

Novel TRPM6 mutations in 21 families with primary hypomagnesemia and secondary hypocalcemia
Journal of the American Society of Nephrology
Schlingmann, K.P. and Sassen, M.C. and Weber, S. and Pechmann, U. and Kusch, K. and Pelken, L. and Lotan, D. and Syrrou, M. and Prebble, J.J. and Cole, D.E.C. and Metzger, D.L. and Rahman, S. and Tajima, T. and Shu, S.-G. and Waldegger, S. and Seyberth, H.W. and Konrad, M.
DOI: 10.1681/ASN.2004110989
2005

Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation
Development
Indra, A.K. and Depé, V. and Bornert, J.-M. and Messaddeq, N. and Yaniv, M. and Mark, M. and Chambon, P. and Metzger, D.
DOI: 10.1242/dev.02019
2005

Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin
Proceedings of the National Academy of Sciences of the United States of America
Li, M. and Messaddeq, N. and Teletin, M. and Pasquali, J.-L. and Metzger, D. and Chambon, P.
DOI: 10.1073/pnas.0507385102
2005

TAF10 is required for the establishment of skin barrier function in foetal, but not in adult mouse epidermis
Developmental Biology
Indra, A.K. and Mohan II, W.S. and Frontini, M. and Scheer, E. and Messaddeq, N. and Metzger, D. and Tora, L.
DOI: 10.1016/j.ydbio.2005.05.043
2005

Temporally controlled targeted somatic mutagenesis in skeletal muscles of the mouse
Genesis
Schuler, M. and Ali, F. and Metzger, E. and Chambon, P. and Metzger, D.
DOI: 10.1002/gene.20107
2005

Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-¿
Journal of Experimental Medicine
Rousseaux, C. and Lefebvre, B. and Dubuquoy, L. and Lefebvre, P. and Romano, O. and Auwerx, J. and Metzger, D. and Wahli, W. and Desvergne, B. and Naccari, G.C. and Chavatte, P. and Farce, A. and Bulois, P. and Cortot, A. and Colombel, J.F. and Desreumaux, P.
DOI: 10.1084/jem.20041948
2005

Long on QT and low on calcium.
Cardiology in the young
DOI: 10.1017/s1047951104006134
PubMed: 15680004
12/2004

Spectrum of HNF1A and GCK mutations in Canadian families with maturity-onset diabetes of the young (MODY).
Clinical and investigative medicine. Medecine clinique et experimentale
PubMed: 15305805
06/2004

Addison’s disease in a child with systemic lupus erythematosus
Pediatric Rheumatology Online Journal
2004

Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression
Genes and Development
McLean, G.W. and Komiyama, N.H. and Serrels, B. and Asano, H. and Reynolds, L. and Conti, F. and Hodivala-Dilke, K. and Metzger, D. and Chambon, P. and Grant, S.G.N. and Frame, M.C.
DOI: 10.1101/gad.316304
2004

Altered growth in male peroxisome proliferator-activated receptor ¿ (PPAR¿) heterozygous mice: Involvement of PPAR¿ in a negative feedback regulation of growth hormone action
Molecular Endocrinology
Rieusset, J. and Seydoux, J. and Anghel, S.I. and Escher, P. and Michalik, L. and Tan, N.S. and Metzger, D. and Chambon, P. and Wahli, W. and Desvergne, B.
DOI: 10.1210/me.2003-0325
2004

Tissue-specific and inducible Cre-mediated recombination in the gut epithelium
Genesis
El Marjou, F. and Janssen, K.-P. and Chang, B.H.-J. and Li, M. and Hindie, V. and Chan, L. and Louvard, D. and Chambon, P. and Metzger, D. and Robine, S.
DOI: 10.1002/gene.20042
2004

Friedreich Ataxia Mouse Models with Progressive Cerebellar and Sensory Ataxia Reveal Autophagic Neurodegeneration in Dorsal Root Ganglia
Journal of Neuroscience
Simon, D. and Seznec, H. and Gansmuller, A. and Carelle, N. and Weber, P. and Metzger, D. and Rustin, P. and Koenig, M. and Puccio, H.
DOI: 10.1523/JNEUROSCI.4549-03.2004
2004

Retinal Dystrophy Resulting from Ablation of RXRa in the Mouse Retinal Pigment Epithelium
American Journal of Pathology
Mori, M. and Metzger, D. and Picaud, S. and Hindelang, C. and Simonutti, M. and Sahel, J. and Chambon, P. and Mark, M.
DOI: 10.1016/S0002-9440(10)63157-4
2004

Long on QT and low on calcium
Cardiology in the Young
Bradley, T.J. and Metzger, D.L. and Sanatani, S.
DOI: 10.1017/S1047951104006134
2004

Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse
Genesis
Schuler, M. and Dierich, A. and Chambon, P. and Metzger, D.
DOI: 10.1002/gene.20039
2004

Brain masculinization requires androgen receptor function
Proceedings of the National Academy of Sciences of the United States of America
Sato, T. and Matsumoto, T. and Kawano, H. and Watanabe, T. and Uematsu, Y. and Sekine, K. and Fukuda, T. and Aihara, K.-I. and Krust, A. and Yamada, T. and Nakamichi, Y. and Yamamoto, Y. and Nakamura, T. and Yoshimura, K. and Yoshizawa, T. and Metzger, D. and Chambon, P. and Kato, S.
DOI: 10.1073/pnas.0305303101
2004

Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development
Development
Andl, T. and Ahn, K. and Kairo, A. and Chu, E.Y. and Wine-Lee, L. and Reddy, S.T. and Croft, N.J. and Cebra-Thomas, J.A. and Metzger, D. and Chambon, P. and Lyons, K.M. and Mishina, Y. and Seykora, J.T. and Crenshaw III, E.B. and Millar, S.E.
DOI: 10.1242/dev.01125
2004

Cre-mediated conditional gene targeting to understand liver functions
Drug Discovery Today: Disease Models
Metzger, D. and Chambon, P.
DOI: 10.1016/j.ddmod.2004.11.021
2004

Peroxisome-Proliferator-Activated Receptor (PPAR)-¿ activation stimulates keratinocyte differentiation
Journal of Investigative Dermatology
Man, M.-Q. and Fowler, A.J. and Schmuth, M. and Lau, P. and Chang, S. and Brown, B.E. and Moser, A.H. and Michalik, L. and Desvergne, B. and Wahli, W. and Li, M. and Metzger, D. and Chambon, P.H. and Elias, P.M. and Feingold, K.R.
DOI: 10.1111/j.0022-202X.2004.23235.x
2004

Peroxisome proliferator-activated receptor ¿ is required in mature white and brown adipocytes for their survival in the mouse
Proceedings of the National Academy of Sciences of the United States of America
Imai, T. and Takakuwa, R. and Marchand, S. and Dentz, E. and Bornert, J.-M. and Messaddeq, N. and Wendling, O. and Mark, M. and Desvergne, B. and Wahli, W. and Chambon, P. and Metzger, D.
DOI: 10.1073/pnas.0400356101
2004

In vivo activation of PPAR target genes by RXR homodimers
EMBO Journal
Ijpenberg, A. and Tan, N.S. and Gelman, L. and Kersten, S. and Seydoux, J. and Xu, J. and Metzger, D. and Canaple, L. and Chambon, P. and Wahli, W. and Desvergne, B.
DOI: 10.1038/sj.emboj.7600209
2004

Spectrum of HNF1A and GCK mutations in Canadian families with maturity-onset diabetes of the young (MODY)
Clinical and Investigative Medicine
McKinney, J.L. and Cao, H. and Robinson, J.F. and Metzger, D.L. and Cummings, E. and Riddell, D.C. and Sanderson, S.R. and Pacaud, D. and Ho, J. and Hegele, R.A.
2004

Current approaches to the prevention of type 1 diabetes
British Columbia Medical Journal
Metzger, D.L.
2004

Current approaches to the prevention of type 1 diabetes
BC Medical Journal
2004

Telephone contact by a diabetes nurse educator improves hemoglobin A1c in adolescents with poorly controlled type 1 diabetes: a randomized controlled trial
Canadian Journal of Diabetes
2003

Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells
Molecular and Cellular Neuroscience
Leone, D.P. and Genoud, S. and Atanasoski, S. and Grausenburger, R. and Berger, P. and Metzger, D. and Macklin, W.B. and Chambon, P. and Suter, U.
DOI: 10.1016/S1044-7431(03)00029-0
2003

TAF10 (TAFII30) is necessary for TFIID stability and early embryogenesis in mice
Molecular and Cellular Biology
Mohan II, W.S. and Scheer, E. and Wendling, O. and Metzger, D. and Tora, L.
DOI: 10.1128/MCB.23.12.4307-4318.2003
2003

Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development
Immunity
Chi, T.H. and Wan, M. and Lee, P.P. and Akashi, K. and Metzger, D. and Chambon, P. and Wilson, C.B. and Crabtree, G.R.
DOI: 10.1016/S1074-7613(03)00199-7
2003

Developing with lethal RA levels: Genetic ablation of Rarg can restore the viability of mice lacking Cyp26a1
Development
Abu-Abed, S. and Dollé, P. and Metzger, D. and Wood, C. and MacLean, G. and Chambon, P. and Petkovich, M.
DOI: 10.1242/dev.00357
2003

Hedgehog Signaling Regulates Sebaceous Gland Development
American Journal of Pathology
Allen, M. and Grachtchouk, M. and Sheng, H. and Grachtchouk, V. and Wang, A. and Wei, L. and Liu, J. and Ramirez, A. and Metzger, D. and Chambon, P. and Jorcano, J. and Dlugosz, A.A.
DOI: 10.1016/S0002-9440(10)63574-2
2003

Suppressive function of androgen receptor in bone resorption
Proceedings of the National Academy of Sciences of the United States of America
Kawano, H. and Sato, T. and Yamada, T. and Matsumoto, T. and Sekine, K. and Watanabe, T. and Nakamura, T. and Fukuda, T. and Yoshimura, K. and Yoshizawa, T. and Aihara, K.-I. and Yamamoto, Y. and Nakamichi, Y. and Metzger, D. and Chambon, P. and Nakamura, K. and Kawaguchi, H. and Kato, S.
DOI: 10.1073/pnas.1533500100
2003

Targeted Conditional Somatic Mutagenesis in the Mouse: Temporally-Controlled Knock Out of Retinoid Receptors in Epidermal Keratinocytes
Methods in Enzymology
Metzger, D. and Indra, A.K. and Li, M. and Chapellier, B. and Calleja, C. and Ghyselinck, N.B. and Chambon, P.
DOI: 10.1016/s0076-6879(03)64022-x
2003

Temporally controlled site-specific mutagenesis in the germ cell lineage of the mouse testis
Biology of Reproduction
Weber, P. and Schuler, M. and Gérard, C. and Mark, M. and Metzger, D. and Chambon, P.
DOI: 10.1095/biolreprod.102.005801
2003

Weekly Telephone Contact by a Diabetes Educator in Adolescents with Type 1 Diabetes
Canadian Journal of Diabetes
Panagiotopoulos, C. and Preston, J.M. and Stewart, L.L. and Metzger, D.L. and Chanoine, J.-P.
2003

GCK and HNF1A mutations in Canadian families with maturity onset diabetes of the young (MODY).
Human mutation
DOI: 10.1002/humu.9090
PubMed: 12442280
12/2002

TNF-related apoptosis-inducing ligand death pathway-mediated human beta-cell destruction.
Diabetologia
DOI: 10.1007/s00125-002-0926-2
PubMed: 12488957
12/2002

Effects of insulin in relatives of patients with type 1 diabetes mellitus.
The New England journal of medicine
DOI: 10.1056/nejmoa012350
PubMed: 12037147
05/2002

beta-cell antigen-specific CD56(+) NKT cells from type 1 diabetic patients: autoaggressive effector T cells damage human CD56(+) beta cells by HLA-restricted and non-HLA-restricted pathways.
Human immunology
DOI: 10.1016/s0198-8859(02)00372-5
PubMed: 12039407
04/2002

Germ cell expression of the transcriptional co-repressor TIF1ß is required for the maintenance of spermatogenesis in the mouse
Development
Weber, P. and Cammas, F. and Gerard, C. and Metzger, D. and Chambon, P. and Losson, R. and Mark, M.
2002

ß-cell antigen-specific CD56+ NKT cells from type 1 diabetic patients: Autoaggressive effector T cells damage human CD56+ ß cells by HLA-restricted and non-HLA-restricted pathways
Human Immunology
Ou, D. and Metzger, D.L. and Wang, X. and Pozzilli, P. and Tingle, A.J.
DOI: 10.1016/S0198-8859(02)00372-5
2002

Site-specific somatic mutagenesis in the retinal pigment epithelium
Investigative Ophthalmology and Visual Science
Mori, M. and Metzger, D. and Garnier, J.-M. and Chambon, P. and Mark, M.
2002

Genetic dissection of retinoic acid function in epidermis physiology,Dissection génétique de la fonction de l'acide rètinoïque dans la physiologie de l'èpiderme
Annales de Dermatologie et de Venereologie
Ghyselinck, N.-B. and Chapellier, B. and Calléja, C. and Indra, A.K. and Li, M. and Messaddeq, N. and Mark, M. and Metzger, D. and Chambon, P.
2002

Nine novel mutations in NR0B1 (DAX1) causing adrenal hypoplasia congenita.
Human mutation
DOI: 10.1002/humu.1236
PubMed: 11748852
12/2001

Spectrum of mutations of the AAAS gene in Allgrove syndrome: lack of mutations in six kindreds with isolated resistance to corticotropin.
The Journal of clinical endocrinology and metabolism
DOI: 10.1210/jc.86.11.5433
PubMed: 11701718
11/2001

High prevalence of celiac disease in patients with type 1 diabetes detected by antibodies to endomysium and tissue transglutaminase.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie
DOI: 10.1155/2001/640796
PubMed: 11381296
05/2001

RXRa ablation in skin keratinocytes results in alopecia and epidermal alterations
Development
Li, M. and Chiba, H. and Warot, X. and Messaddeq, N. and Gérard, C. and Chambon, P. and Metzger, D.
2001

Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor a mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes
Proceedings of the National Academy of Sciences of the United States of America
Imai, T. and Jiang, M. and Chambon, P. and Metzger, D.
DOI: 10.1073/pnas.011528898
2001

An efficient system for conditional gene expression in embryonic stem cells and in their in vitro and in vivo differentiated derivatives
Proceedings of the National Academy of Sciences of the United States of America
Vallier, L. and Mancip, J. and Markossian, S. and Lukaszewicz, A. and Dehay, C. and Metzger, D. and Chambon, P. and Samarut, J. and Savatier, P.
DOI: 10.1073/pnas.041617198
2001

The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures
Genes and Development
Abu-Abed, S. and Dollé, P. and Metzger, D. and Beckett, B. and Chambon, P. and Petkovich, M.
DOI: 10.1101/gad.855001
2001

Spectrum of mutations of the AAAS gene in allgrove syndrome: Lack of mutations in six kindreds with isolated resistance to corticotropin
Journal of Clinical Endocrinology and Metabolism
Sandrini, F. and Farmakidis, C. and Kirschner, L.S. and Wu, S.-M. and Tullio-Pelet, A. and Lyonnet, S. and Metzger, D.L. and Bourdony, C.J. and Tiosano, D. and Chan, W.-Y. and Stratakis, C.A.
DOI: 10.1210/jcem.86.11.8037
2001

Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)a and PPARß mutant mice
Journal of Cell Biology
Michalik, L. and Desvergne, B. and Tan, N.S. and Basu-Modak, S. and Escher, P. and Rieusset, J. and Peters, J.M. and Kaya, G. and Gonzalez, F.J. and Zakany, J. and Metzger, D. and Chambon, P. and Duboule, D. and Wahli, W.
DOI: 10.1083/jcb.200011148
2001

Selective ablation of retinoid X receptor a in hepatocytes impairs their lifespan and regenerative capacity
Proceedings of the National Academy of Sciences of the United States of America
Imai, T. and Jiang, M. and Kastner, P. and Chambon, P. and Metzger, D.
DOI: 10.1073/pnas.071056098
2001

Site- and time-specific gene targeting in the mouse
Methods
Metzger, D. and Chambon, P.
DOI: 10.1006/meth.2001.1159
2001

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
EMBO Journal
Rangarajan, A. and Talora, C. and Okuyama, R. and Nicolas, M. and Mammucari, C. and Oh, H. and Aster, J.C. and Krishna, S. and Metzger, D. and Chambon, P. and Miele, L. and Aguet, M. and Radtke, F. and Dotto, G.P.
DOI: 10.1093/emboj/20.13.3427
2001

Temporally controlled targeted somatic mutagenesis in the mouse brain
European Journal of Neuroscience
Weber, P. and Metzger, D. and Chambon, P.
DOI: 10.1046/j.0953-816X.2001.01803.x
2001

Increased prevalence of celiac disease in girls with Turner syndrome detected using antibodies to endomysium and tissue transglutaminase.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie
DOI: 10.1155/2000/172914
PubMed: 11125180
12/2000

Cross-reactive rubella virus and glutamic acid decarboxylase (65 and 67) protein determinants recognised by T cells of patients with type I diabetes mellitus.
Diabetologia
DOI: 10.1007/s001250051373
PubMed: 10907121
06/2000

Cross-reactive rubella virus and glutamic acid decarboxylase (65 and 67) protein determinants recognised by T cells of patients with Type I diabetes mellitus
Diabetologia
Ou, D. and Mitchell, L.A. and Metzger, D.L. and Gillam, S. and Tingle, A.J.
2000

F9 Embryonal carcinoma cells engineered for tamoxifen-dependent Cre-mediated site-directed mutagenesis and doxycycline-inducible gene expression
Experimental Cell Research
Chiba, H. and Chambon, P. and Metzger, D.
DOI: 10.1006/excr.2000.5022
2000

Inducible site-specific somatic mutagenesis in mouse hepatocytes
Genesis
Imai, T. and Chambon, P. and Metzger, D.
DOI: 10.1002/(SICI)1526-968X(200002)26:23.0.CO;2-3
2000

Temporally controlled somatic mutagenesis in smooth muscle
Genesis
Kühbandner, S. and Brummer, S. and Metzger, D. and Chambon, P. and Hofmann, F. and Feil, R.
DOI: 10.1002/1526-968X(200009)28:13.0.CO;2-C
2000

p300 Mediates functional synergism between AF-1 and AF-2 of estrogen receptor a and ß by interacting directly with the N-terminal A/B domains
Journal of Biological Chemistry
Kobayashi, Y. and Kitamoto, T. and Masuhiro, Y. and Watanabe, M. and Kase, T. and Metzger, D. and Yanagisawa, J. and Kato, S.
DOI: 10.1074/jbc.M000042200
2000

Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene
Journal of Biological Chemistry
Kersten, S. and Mandard, S. and Tan, N.S. and Escher, P. and Metzger, D. and Chambon, P. and Gonzalez, F.J. and Desvergne, B. and Wahli, W.
DOI: 10.1074/jbc.M004029200
2000

Targeted somatic mutagenesis in mouse epidermis
Hormone Research
Indra, A.K. and Li, M. and Brocard, J. and Warot, X. and Bornert, J.-M. and Gérard, C. and Messaddeq, N. and Chambon, P. and Metzger, D.
DOI: 10.1159/000053275
2000

A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes
Molecular Cell
Bultman, S. and Gebuhr, T. and Yee, D. and La Mantia, C. and Nicholson, J. and Gilliam, A. and Randazzo, F. and Metzger, D. and Chambon, P. and Crabtree, G. and Magnuson, T.
DOI: 10.1016/S1097-2765(00)00127-1
2000

Skin abnormalities generated by temporally controlled RXRa mutations in mouse epidermis
Nature
Li, M. and Indra, A.K. and Warot, X. and Brocard, J. and Messaddeq, N. and Kato, S. and Metzger, D. and Chambon, P.
DOI: 10.1038/35036595
2000

CD4+ and CD8+ T-cell clones from congenital rubella syndrome patients with IDDM recognize overlapping GAD65 protein epitopes. Implications for HLA class I and II allelic linkage to disease susceptibility.
Human immunology
DOI: 10.1016/s0198-8859(99)00037-3
PubMed: 10439311
08/1999

Sex-Steroid—Hormone Modulation of the Somatotropic Axis During Normal Male Puberty
Sex-Steroid Interactions with Growth Hormone
Daniel L. Metzger and James R. Kerrigan
DOI: 10.1007/978-1-4612-1546-2_4
1999

Mammalian TAF(II)30 is required for cell cycle progression and specific cellular differentiation programmes
EMBO Journal
Metzger, D. and Scheer, E. and Soldatov, A. and Tora, L.
DOI: 10.1093/emboj/18.17.4823
1999

Engineering the mouse genome by site-specific recombination
Current Opinion in Biotechnology
Metzger, D. and Feil, R.
DOI: 10.1016/S0958-1669(99)00012-9
1999

CD4+ and CD8+ T-cell clones from congenital Rubella syndrome patients with IDDM recognize overlapping GAD65 protein epitopes: Implications for HLA class I and II allelic linkage to disease susceptibility
Human Immunology
Ou, D. and Jonsen, L.A. and Metzger, D.L. and Tingle, A.J.
DOI: 10.1016/S0198-8859(99)00037-3
1999

Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: Comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases
Nucleic Acids Research
Indra, A.K. and Warot, X. and Brocard, J. and Bornert, J.-M. and Xiao, J.-H. and Chambon, P. and Metzger, D.
DOI: 10.1093/nar/27.22.4324
1999

Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor a
Molecular and Cellular Biology
Endoh, H. and Maruyama, K. and Masuhiro, Y. and Kobayashi, Y. and Goto, M. and Tai, H. and Yanagisawa, J. and Metzger, D. and Hashimoto, S. and Kato, S.
DOI: 10.1128/mcb.19.8.5363
1999

Antenatal treatment for classic 21-hydroxylase forms of congenital adrenal hyperplasia and the issues.
Genetics in medicine : official journal of the American College of Medical Genetics
PubMed: 11256677
1999

A provincial protocol for the treatment of diabetic ketoacidosis in children
BC Medical Journal
1998

Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor ¿ and retinoid X receptor a
Journal of Biological Chemistry
Abu-Abed, S.S. and Beckett, B.R. and Chiba, H. and Chithalen, J.V. and Jones, G. and Metzger, D. and Chambon, P. and Petkovich, M.
DOI: 10.1074/jbc.273.4.2409
1998

A chimeric Cre recombinase inducible by synthetic, but not by natural ligands of the glucocorticoid receptor
Nucleic Acids Research
Brocard, J. and Feil, R. and Chambon, P. and Metzger, D.
DOI: 10.1093/nar/26.17.4086
1998

Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth hormone)-insulin-like growth factor I axis in the human: evidence from pubertal pathophysiology and sex-steroid hormone replacement.
The Journal of Clinical Endocrinology and Metabolism
DOI: 10.1210/jcem.82.10.4317
PubMed: 9329378
10/1997

The short-term infusion of ovine corticotropin-releasing hormone does not alter luteinizing hormone concentrations in young adult men.
The Journal of Clinical Endocrinology and Metabolism
DOI: 10.1210/jcem.82.2.3782
PubMed: 9024279
02/1997

The short-term infusion of ovine corticotropin-releasing hormone does not alter luteinizing hormone concentrations in young adult men
Journal of Clinical Endocrinology and Metabolism
Metzger, D.L. and Kerrigan, J.R. and Rogol, A.D.
DOI: 10.1210/jc.82.2.697
1997

Specific and redundant functions of retinoid X receptor/retinoic acid receptor heterodimers in differentiation, proliferation, and apoptosis of F9 embryonal carcinoma cells
Journal of Cell Biology
Chiba, H. and Clifford, J. and Metzger, D. and Chambon, P.
DOI: 10.1083/jcb.139.3.735
1997

Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains
Biochemical and Biophysical Research Communications
Feil, R. and Wagner, J. and Metzger, D. and Chambon, P.
DOI: 10.1006/bbrc.1997.7124
1997

Spatio-temporally controlled site-specific somatic mutagenesis in the mouse
Proceedings of the National Academy of Sciences of the United States of America
Brocard, J. and Warot, X. and Wendling, O. and Messaddeq, N. and Vonesch, J.-L. and Chambon, P. and Metzger, D.
DOI: 10.1073/pnas.94.26.14559
1997

Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells
Molecular and Cellular Biology
Chiba, H. and Clifford, J. and Metzger, D. and Chambon, P.
DOI: 10.1128/MCB.17.6.3013
1997

Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth homone)-insulin- like growth factor I axis in the human: Evidence from pubertal pathophysiology and sex-steroid hormone replacement
Journal of Clinical Endocrinology and Metabolism
Veldhuis, J.D. and Metzger, D.L. and Martha Jr., P.M. and Mauras, N. and Kerrigan, J.R. and Keenan, B. and Rogol, A.D. and Pincus, S.M.
DOI: 10.1210/jc.82.10.3414
1997

SNF2ß-BRG1 is essential for the viability of F9 murine embryonal carcinoma cells
Molecular and Cellular Biology
Sumi-Ichinose, C. and Ichinose, H. and Metzger, D. and Chambon, P.
DOI: 10.1128/mcb.17.10.5976
1997

RXRa-null F9 embryonal carcinoma cells are resistant to the differentiation, anti-proliferative and apoptotic effects of retinoids
EMBO Journal
Clifford, J. and Chiba, H. and Sobieszczuk, D. and Metzger, D. and Chambon, P.
DOI: 10.1002/j.1460-2075.1996.tb00789.x
1996

Ligand-activated site-specific recombination in mice
Proceedings of the National Academy of Sciences of the United States of America
Feil, R. and Brocard, J. and Mascrez, B. and Lemeur, M. and Metzger, D. and Chambon, P.
DOI: 10.1073/pnas.93.20.10887
1996

Estrogen and diclofenac sodium therapy in a prepubertal female with idiopathic juvenile osteoporosis.
Journal of pediatric endocrinology & metabolism : JPEM
DOI: 10.1515/jpem.1995.8.2.135
PubMed: 7584708
1995

Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
Science
Kato, S. and Endoh, H. and Masuhiro, Y. and Kitamoto, T. and Uchiyama, S. and Sasaki, H. and Masushige, S. and Gotoh, Y. and Nishida, E. and Kawashima, H. and Metzger, D. and Chambon, P.
DOI: 10.1126/science.270.5241.1491
1995

Conditional site-specific recombination in mammalian cells using a ligand- dependent chimeric Cre recombinase
Proceedings of the National Academy of Sciences of the United States of America
Metzger, D. and Clifford, J. and Chiba, H. and Chambon, P.
DOI: 10.1073/pnas.92.15.6991
1995

Estrogen and Diclofenac Sodium Therapy in a Prepubertal Female with Idiopathic Juvenile Osteoporosis
Journal of Pediatric Endocrinology and Metabolism
Wright, N.M. and Key, L.L. and Metzger, D.L.
DOI: 10.1515/JPEM.1995.8.2.135
1995

Effect of antagonists on DNA binding properties of the human estrogen receptor in vitro and in vivo
Molecular Endocrinology
Metzger, D. and Berry, M. and Ali, S. and Chambon, P.
DOI: 10.1210/mend.9.5.7565805
1995

Characterization of the amino-terminal transcriptional activation function of the human estrogen receptor in animal and yeast cells
Journal of Biological Chemistry
Metzger, D. and Ali, S. and Bornert, J.-M. and Chambon, P.
DOI: 10.1074/jbc.270.16.9535
1995

Gonadal steroid hormone regulation of the somatotropic axis during puberty in humans Mechanisms of androgen and estrogen action.
Trends in endocrinology and metabolism: TEM
DOI: 10.1016/1043-2760(94)p3204-k
PubMed: 18407221
09/1994

Estrogen receptor blockade with tamoxifen diminishes growth hormone secretion in boys: evidence for a stimulatory role of endogenous estrogens during male adolescence.
The Journal of clinical endocrinology and metabolism
DOI: 10.1210/jcem.79.2.8045971
PubMed: 8045971
08/1994

Radiological case of the month. Case 2. Untreated chronic lymphocytic thyroiditis presenting as a pituitary mass and secondary hypocortisolism.
Archives of pediatrics & adolescent medicine
DOI: 10.1001/archpedi.1994.02170070059010
PubMed: 8019626
07/1994

The hepatopulmonary syndrome masquerading as pulmonary Langerhans-cell histiocytosis. Hepatopulmonary Syndrome Study Group.
Annals of internal medicine
DOI: 10.7326/0003-4819-121-1-199407010-00006
PubMed: 8198345
07/1994

The hepatopulmonary syndrome masquerading as pulmonary Langerhans-cell histiocytosis
Annals of Internal Medicine
Caldwell, S.H. and Brantley, K. and Dent, J. and Keeley, R.C. and Pruett, T. and Angle, J.F. and Gaffey, M. and Waldron, P. and Metzger, D.L. and Stevenson, W.C. and Ishitani, M. and Dickson, R.C. and Dye, K.R.
1994

Gonadal steroid hormone regulation of the somatotropic axis during puberty in humans. Mechanisms of androgen and estrogen action
Trends in Endocrinology and Metabolism
Metzger, D.L. and Kerrigan, J.R. and Rogol, A.D.
DOI: 10.1016/1043-2760(94)P3204-K
1994

Cholinergic and opioid involvement in release of growth hormone during exercise and recovery.
Journal of applied physiology (Bethesda, Md. : 1985)
PubMed: 8226493
08/1993

Characterization of pulsatile secretion and clearance of plasma cortisol in premature and term neonates using deconvolution analysis.
The Journal of Clinical Endocrinology and Metabolism
DOI: 10.1210/jcem.77.2.8345052
PubMed: 8345052
08/1993

Permanent neonatal diabetes mellitus and pancreatic exocrine insufficiency resulting from congenital pancreatic agenesis.
American journal of diseases of children (1960)
PubMed: 8506821
06/1993

Alterations in the neuroendocrine control of growth hormone secretion in the uremic rat.
Kidney international
DOI: 10.1038/ki.1993.146
PubMed: 8099633
05/1993

Androgen receptor blockade with flutamide enhances growth hormone secretion in late pubertal males: evidence for independent actions of estrogen and androgen.
The Journal of clinical endocrinology and metabolism
DOI: 10.1210/jcem.76.5.8496305
PubMed: 8496305
05/1993

Cholinergic and opioid involvement in release of growth hormone during exercise and recovery
Journal of Applied Physiology
Thompson, D.L. and Weltman, J.Y. and Rogol, A.D. and Metzger, D.L. and Veldhuis, J.D. and Weltman, A.
1993

Production and characterization of monoclonal antibodies recognising defined regions of the human oestrogen receptor
Hybridoma
Ali, S. and Lutz, Y. and Bellocq, J.-P. and Chenard-Neu, M.-P. and Rouyer, N. and Metzger, D.
DOI: 10.1089/hyb.1993.12.391
1993

Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region
EMBO Journal
Ali, S. and Metzger, D. and Bornert, J.-M. and Chambon, P.
DOI: 10.1002/j.1460-2075.1993.tb05756.x
1993

Permanent Neonatal Diabetes Mellitus and Pancreatic Exocrine Insufficiency Resulting From Congenital Pancreatic Agenesis
American Journal of Diseases of Children
Wright, N.M. and Metzger, D.L. and Borowitz, S.M. and Clarke, W.L.
DOI: 10.1001/archpedi.1993.02160300013005
1993

Promoter specificity of the two transcriptional activation functions of the human oestrogen receptor in yeast
Nucleic Acids Research
Metzger, D. and Losson, R. and Bornert, J.-M. and Lemoine, Y. and Chambon, P.
DOI: 10.1093/nar/20.11.2813
1992

Mechanisms of antihormone action
Journal of Steroid Biochemistry and Molecular Biology
Gronemeyer, H. and Benhamou, B. and Berry, M. and Bocquel, M.T. and Gofflo, D. and Garcia, T. and Lerouge, T. and Metzger, D. and Meyer, M.E. and Tora, L. and Vergezac, A. and Chambon, P.
DOI: 10.1016/0960-0760(92)90347-L
1992

Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen
EMBO Journal
Berry, M. and Metzger, D. and Chambon, P.
1990

The lack of transcriptional activation of the v-erbA oncogene is in part due to a mutation present in the DNA binding domain of the protein
Nucleic Acids Research
Verneuil, H.D. and Metzger, D.
DOI: 10.1093/nar/18.15.4489
1990

The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties
EMBO Journal
Tora, L. and Mullick, A. and Metzger, D. and Ponglikitmongkol, M. and Park, I. and Chambon, P.
DOI: 10.1002/j.1460-2075.1989.tb03604.x
1989

Expression and function of the human estrogen receptor in yeast
Cold Spring Harbor Symposia on Quantitative Biology
White, J.H. and Metzger, D. and Chambon, P.
DOI: 10.1101/sqb.1988.053.01.093
1988

The human oestrogen receptor functions in yeast
Nature
Metzger, D. and White, J.H. and Chambon, P.
DOI: 10.1038/334031a0
1988

Research

Current Project
I am currently involved in two multicenter trials involved with either the prevention or the early treatment of type 1 diabetes: the Diabetes TrialNet and the TRIGR (Trial to Reduce IDDM in the Genetically at Risk).

I also work closely with basic-science researchers at BCRI and at The Centre of Human Islet Transplant and Beta Cell Regeneration at VGH on an variety of studies related to the various immunological processes involved in the development of type 1 diabetes in humans.

Finally, I am a co-investigator in research evaluating a comprehensive provincial health care model for children with diabetes using existing population databases.

Honours & Awards

Outstanding Achievement Award, Canadian Diabetes Association — 2003

Family-Centred Care Award of Distinction, BCCH Partners in Care — 2003

The Noni MacDonald Award, Canadian Pediatric Society — 2014

Research Group Members

Karnjit Sarai, Volunteer