Overview

My research is primarily involved in the development, prevention and treatment of type 1 (insulin-dependent or juvenile-onset) diabetes.

I am an investigator in several multicenter clinical trials involved in preventing type 1 diabetes. In addition, I collaborate with basic-science researchers from the BC Research Institute and from the The Centre of Human Islet Transplant and Beta Cell Regeneration at VGH, helping provide clinical material (most commonly, blood samples) for their research.

I also maintain our Division's large website providing resources for families of children with diabetes and other endocrine disorders, and for the professionals caring for these patients.

Most recently, working with local and provincial resources, I have helped initiate an endocrine treatment program for transgendered youth.

Publications

Is Age a Risk Factor for Cerebral Edema in Children With Diabetic Ketoacidosis? A Literature Review
Canadian Journal of Diabetes
Glackin, S. and Metzger, D. and Hanas, R. and Chanoine, J.-P.
DOI: 10.1016/j.jcjd.2019.04.013
2020

PGC-1ß modulates statin-associated myotoxicity in mice
Archives of Toxicology
Singh, F. and Zoll, J. and Duthaler, U. and Charles, A.-L. and Panajatovic, M.V. and Laverny, G. and McWilliams, T.G. and Metzger, D. and Geny, B. and Kr{\"a}henb{\"u}hl, S. and Bouitbir, J.
DOI: 10.1007/s00204-018-2369-7
2019

Aging exacerbates ischemia-reperfusion-induced mitochondrial respiration impairment in skeletal muscle
Antioxidants
Paradis, S. and Charles, A.-L. and Georg, I. and Goupilleau, F. and Meyer, A. and Kindo, M. and Laverny, G. and Metzger, D. and Geny, B.
DOI: 10.3390/antiox8060168
2019

Senescence controls prostatic neoplasia driven by Pten loss
Molecular and Cellular Oncology
Parisotto, M. and Grelet, E. and El Bizri, R. and Metzger, D.
DOI: 10.1080/23723556.2018.1511205
2019

Skeletal muscle–specific activation of Gq signaling maintains glucose homeostasis
Diabetes
Bone, D.B.J. and Meister, J. and Knudsen, J.R. and Dattaroy, D. and Cohen, A. and Lee, R. and Lu, H. and Metzger, D. and Jensen, T.E. and Wess, J.
DOI: 10.2337/db18-0796
2019

Growth hormone supplementation and psychosocial functioning to adult height in Turner syndrome: A questionnaire study of participants in the Canadian randomized trial
Frontiers in Endocrinology
Rovet, J.F. and Van Vliet, G. and Curtis, J.A. and Cummings, E. and Salisbury, S.R. and Szots, F. and Khoury, K. and Collu, R. and Deal, C.L. and Huot, C. and Barnes, R.D. and Guyda, H.J. and Legault, L. and Polychronakos, C. and Rodd, C. and Faught, K.A. and Lawrence, S.E. and Lawson, M.L. and Alexander, D.S. and Daneman, D. and Bailey, J.D. and Ehrlich, R.M. and Perlman, K. and Sochett, E. and MacMillan, A.B. and Holland, F.J. and Vander Meulen, J.A. and Clarson, C.L. and Jenner, M.R.F. and Dean, H.J. and Taback, S.P. and Best, T.B. and Bruce, G.A. and Couch, R.M. and McCoy, E.E. and Stephure, D.K. and Kitson, H.F. and Metzger, D. and Stewart, L.L. and Tze, W.J. and Boulton, B.C.
DOI: 10.3389/fendo.2019.00125
2019

Prevalence and Severity of High Blood Pressure Among Children Based on the 2017 American Academy of Pediatrics Guidelines
JAMA Pediatrics
Atul K. Sharma and Daniel L. Metzger and Celia J. Rodd
DOI: 10.1001/jamapediatrics.2018.0223
06/2018

Glucose control and autonomic response during acute stress in youth with type 1 diabetes: A pilot study.
Pediatric diabetes
Guan L and Metzger DL and Lavoie PM and Collet JP
DOI: 10.1111/pedi.12680
PubMed: 29654713
05/2018

Ligand-Independent Actions of Vitamin D Receptor
Vitamin D: Fourth Edition
Laverny, G. and Metzger, D.
DOI: 10.1016/B978-0-12-809965-0.00012-4
2018

Effect of hydrolyzed infant formula vs conventional formula on risk of type 1 diabetes the TRIGR randomized clinical trial
JAMA - Journal of the American Medical Association
Knip, M. and ?kerblom, H.K. and Altaji, E. and Becker, D. and Bruining, J. and Castano, L. and Danne, T. and De Beaufort, C. and Dosch, H.-M. and Dupre, J. and Fraser, W.D. and Howard, N. and Ilonen, J. and Konrad, D. and Kordonouri, O. and Krischer, J.P. and Lawson, M.L. and Ludvigsson, J. and Madacsy, L. and Mahon, J.L. and Ormisson, A. and Palmer, J.P. and Pozzilli, P. and Savilahti, E. and Serrano-Rios, M. and Songini, M. and Taback, S. and Vaarala, O. and White, N.H. and Virtanen, S.M. and Wasikowa, R. and Mandrup-Poulsen, T. and Arjas, E. and Lernmark, ?. and L{\"a}{\"a}r{\"a}, E. and Schmidt, B. and Hyytinen, M. and Koski, K. and Koski, M. and Merentie, K. and Pajakkala, E. and Reunanen, A. and Salonen, M. and Terhonen, T. and Virkkunen, S. and Cuthbertson, D. and Gainer, B. and Hadley, D. and Malloy, J. and Nallamshetty, L. and Shanker, L. and Bradley, B. and Lough, G. and Fraser, W. and Sermer, M. and Taback, S.P. and Franciscus, M. and Nucci, A. and Palmer, J. and Alahuhta, K. and B{\"a}rlund, S. and Korhonen, T. and Kovanen, L. and Lehtonen, E. and Niinist{\"o}, S. and Pekkala, M. and Sorkio, S. and Toivanen, L. and V{\"a}h{\"a}talo, L. and Uusitalo, U. and {\"O}hman, T. and Bongiorno, R. and Catteau, J. and Fraser, G. and Lloyd, M. and Crock, P. and Giles, M. and Siech, K. and See, D.W. and Brown, C. and Craig, M. and Johnston, A. and Bere, L.J. and Clarson, C.L. and Jenner, M. and McManus, R. and Renato, N. and Lovell, M. and Higo, D. and Kent, N. and Kwan, J. and Marshall, C. and Metzger, D. and Chanoine, J.-P. and Stewart, L. and Thompson, D. and Edwards, A. and Lange, I. and Mercer, J. and Pacaud, D. and Josephine, H. and Schwarz, W. and Stephure, D.K. and Boer, J. and Chatur, T. and Chick, C. and Couch, B. and Demianczuk, N. and Girgis, R. and Marks, S. and Ryan, E. and Thompson, M. and Dean, H.J. and Grant, L. and Hamelin, K. and LaForte, J. and Murphy, L. and Catte, D. and Schneider, C. and Sellers, E.A.C. and Woo, V. and Boland, A. and Clark, H.D. and Cooper, T. and Gruslin, A. and Karovitch, A. and Keely, E. and Malcolm, J.C. and Sauro, V. and Tawagi, G.F. and Andrighetti, S. and Arnold, G. and Barrett, J. and Blumer, I. and Daneman, D. and Donat, D. and Ehrlich, R. and Feig, D. and Gottesman, I. and Gysler, M. and Karkanis, S. and Kenshole, A. and Knight, B. and Lackie, E. and Lewis, V. and Martin, M.J. and Maxwell, C. and Oliver, G. and Panchum, P. and Shilletto, N. and Simone, A. and Skidmore, M. and Turrini, T. and Wong, S. and Allen, C. and B{\'e}langer, L. and Bouchard, I. and Ferland, S. and Frenette, L. and Garrido-Russo, M. and Leblanc, M. and Imbeault, J. and Morin, V. and Olivier, G. and Weisnagell, J. and Costain, G. and Dornan, J. and Heath, K. and MacSween, M.-C. and McGibbon, A. and Ramsay, C. and Sanderson, F. and Sanderson, S. and Benabdesselam, L. and Gonthier, M. and Huot, C. and Thibeault, M. and Laforte, D. and Legault, L. and Perron, P. and Armson, A. and Canning, P. and Cummings, E.A. and Ivanko, V. and McLeod, L. and Mokashi, A. and Scott, K. and Bridger, T. and Crane, J. and Crummell, C. and Curtis, J.C. and Dawson, C. and Joyce, C. and Newhook, L.A. and Newman, S. and Druken, E. and Begum-Hasan, J. and Breen, A. and Houlden, R. and Woods, M. and Carrson, G. and Kelly, S. and Martel, M.J. and Penner, M. and Sankaran, K. and Hardy-Brown, K. and King, N. and White, R.A. and Park, M. and Popkin, J. and Robson, L. and Coles, K. and Al Taji, E. and Cerna, M. and Cerny, M. and Francova, H. and Hainerova, I. and Kothankova, H. and Koukalova, R. and Krakorova, V. and Mendlova, P. and Sitova, R. and Stechova, K. and Vavrinec, J. and Vosahlo, J. and Zlatohlavkova, B. and Brazdova, L. and Faksova, P. and Gregorova, D. and Kantor, L. and Malkova, K. and Venhacova, J. and Venhacova, P. and Cipra, A. and Skvor, J. and Budejovice, C. and Tomsikova, Z. and Botkova-Krauseova, H. and Mockova, A. and Paterov{\'a}, P. and Gogelova, P. and Kandrnalova, J. and Einberg, {\"U}. and Jakovlev, {\"U}. and Posiadlo, S. and Rannaste, E. and Raukas, R. and Riikj{\"a}rv, M.-A. and Valla, K. and Astover, V. and Kirss, A. and Retpap, J. and T{\"a}ht, E. and Tillmann, V. and Vahtra, S. and Heikkil{\"a}, M. and Hirvasniemi, M. and Luopaj{\"a}rvi, K. and Johansson, S. and Kleemola, P. and Laukkanen, E. and Parkkola, A. and Pigg, H.-M. and Puttonen, H. and Renlund, M. and Salonen, K. and Suomalainen, H. and Tenkula, T. and Teramo, K. and J{\"a}rvenp{\"a}{\"a}, A.-L. and H{\"a}m{\"a}lainen, A.-M. and Jussila, R. and Kiiveri, S. and Haavisto, H. and Holopainen, S. and Kupiainen, H. and Leeve, T. and Lumme, K. and Nironen, T. and Salonen, M. and Tenhola, S. and Tiilikainen, T. and Keinonen, H. and Lautala, P. and Salonen, P. and Vesanto, M. and Aspholm, A.S. and Asunta, P. and Ik{\"a}valko, H. and Jason, E. and J{\"a}minki, S. and Kekki, P. and Koskinen, M. and Lehtim{\"a}ki, S. and L{\"a}hde, J. and M{\"a}kel{\"a}, M. and Peltoniemi, S. and Poutiainen, L. and Ranta, K. and Salonsaari, T. and Sarviharju-Tujula, S.-L. and Selvenius, J. and Siljander, H. and Haanp{\"a}{\"a}, P.-L. and Holm, C. and Juutilainen, A. and J{\"a}rvel{\"a}inen, V. and Kangaskolkka-Keskilohko, A.-M. and Laino, E. and Marjam{\"a}ki, L. and Suominen, E. and Ylitalo, S. and Hokkanen, M. and Lounamaa, R. and Matikainen, M. and Nuuja, A. and Paalanen, I. and Puupponen, A.R. and Salo-Edwards, H. and Alanne, S. and Kultti, T. and Linjama, H. and Muhonen, K. and V{\"a}{\"a}r{\"a}niemi, M. and Talvitie, T. and Backman, M. and Hanhij{\"a}rvi, R. and Koivula, P. and Lindstr{\"o}m, K. and Martikainen, A. and Nurmi, P. and Bj{\"o}rk, A. and Huopio, H. and Komulainen, J. and Lehtom{\"a}ki, S. and Muikku, E. and Pesola, J. and Sankilampi, U. and Arkkola, T. and Hekkala, A. and Jurvakainen, S. and Koivikko, M.-L. and K{\"a}h{\"o}nen, M. and Leinonen, E. and Mykk{\"a}nen, T. and Pohjola, H. and Riikonen, K. and Niittyvuopio, A. and Stenius, A. and Tapanainen, P. and Veijola, R. and Alar, A. and Jovio, S. and Korpela, P. and M{\"a}kinen, E. and Hietanen, L. and Kivist{\"o}, J. and K{\"a}{\"a}r, M.-L. and Lehtim{\"a}ki, P. and Mustila, T. and Popov, E. and S{\"a}{\"a}tel{\"a}, S. and Taittonen, L. and Ahtiainen, K. and Laaksonen, N. and Luoto, M. and Viitala, J. and Virransalo, R. and Nyk{\"a}nen, P. and Paajanen, S. and Parkkinen, S. and Pyrh{\"o}nen, H. and S{\"a}rkk{\"a}, T. and Aschemeier, B. and Bektas, S. and Biester, T. and Datz, N. and Deiss, D. and Fath, M. and L{\"u}pke, K. and M{\"u}ller, B. and Nestoris, C. and Rothes, S. and Sadeghian, E. and Semler, K. and Arat{\'o}, A. and Krikovszky, D. and Nobilis, A. and Sz{\'e}n{\'a}si, J. and Benevento, D. and Anguissola, G.B. and Biagioni, M. and Bizzarri, C. and Cherubini, V. and Ferrito, L. and Giordano, C. and Giorgetti, C. and Khazrai, Y.M. and Kyanvash, S. and Maddaloni, E. and Napoli, A. and Piergiovanni, F. and Pitocco, D. and Suraci, T. and Tabacco, G. and Valente, L. and Visalli, N. and Carboni, M.B. and Cavallo, R. and Cau, V. and Isola, C. and Ledda, A. and Loddo, M. and Mannu, C. and Pettinau, M. and Pisano, S. and Porceddu, M. and Putzu, C. and Rita, A. and Peters, D. and Schierloh, U. and Bisschoff, M. and Blonk, L. and Lappenschaar, T. and Manai, B. and Seesink, M. and Sperling-Conrad, M. and Verhagen, M. and Zoethout, J.A. and Basiak, A. and Chalas, M. and Chesiak, M. and Gramza, A. and Iwankiewicz, J. and Sieradzan, E. and Wikiera, B. and Ciechanowska, M. and Dziatkowiak, H. and Futona, B. and G{\'o}rska, A. and Glowacka-W{\'o}ny, M. and Kaim, I. and Klich, B. and Starzyk, J. and Wolanin, M. and Tokarska, L. and Chucherco, D. and Deja, G. and Firek-Pedras, M. and Jarosz-Chobot, P. and Kalina, M. and Kutrowska-Adamusiak, K. and Minkina-Pedras, M. and Muchaka-Bianga, M. and Bodalski, J. and Mlynarski, W. and Szadkowska, A. and Cieslak, A. and Cypryk, K. and Dziatosz, K. and Jastzebowska, J. and Krysiak, A. and Szymanska, U. and Wilcz?ski, J. and Zawodniak-Szalapska, M. and Aguay, A. and Bilbao, J.R. and Chueca, M. and Cortazar, A. and Echarte, G. and Frutos, T.G. and Jimenez, P. and Martul, P. and Moreno, A. and Oyarzabal, M. and Rica, I. and Salgado, Y. and Mart{\'i}nez-Larrad, M.T. and Hawkins, F.G. and Hern{\'a}ndez, R. and Herranz, L. and Pallardo, L.F. and Deibarra, L.S. and Fernandez, B.H. and Luis, J.L. and Ort{\'i}z-Quintana, L. and Recarte, P.P. and Arnau, D.R. and Aronsson, L. and Bod{\'e}n, S. and Fredriksson, J. and Isacsson, E. and Johansson, I. and Karlsson, E. and Lock, C. and Sandstr{\"o}m, A.-M. and Konefal, M.S. and Andreasson, C. and Dahlstr{\"o}m, U. and Hanas, R. and Lundqvist, K. and Windell, L. and Jansson, I. and Karlsson, A.-K. and Lindbladh, B. and Odenman, I. and Pettersson, C. and Sundberg, F. and Sundqvist, M. and Aronsson, S. and Bellman, I. and Bengtsson, A.-B. and Lyd{\'e}n, G.-B. and Nilsson, N.-O. and S{\"o}derblom, M. and Unt, C. and Augustsson, M. and Bengtsson, M. and Fors, H. and Helmrich, A. and Johansson, T.O. and Andersson, A.-C. and Boiard-St{\"o}mlid, A. and Hellgren, G. and K{\"a}llsholm, H. and Lindqvist, J. and Nilsson, M. and Nordwall, M. and Str{\"o}mstedt, C. and ?hsberg, C. and Lindh, A. and Lindhe, C. and Samuelsson, C. and Wiik, A. and Edenwall, H. and Ljumgcrantz, M. and Persson, I.-B. and Strigard, E. and Svensson, B.-L. and ?man, J. and Breivik, G.-E. and Detlofsson, I.-L. and Kroon, M. and S{\"a}rnblad, S. and Johansson, C. and Ilvered, R. and Lundberg, A. and ?kesson, K. and Beccarelli, A. and Gadient, M. and Rappold-Amrein, C. and Schoenle, E. and Daftary, A. and Damagro-Elias, M.E. and Gilmour, C. and Klein, M.B. and Lain, C. and Salerno, D. and Smith, M.E. and Vats, K. and Pfaff, D.J. and Malone, P. and Mansfield, P. and Munns, M. and Nickel, K. and Pompilio, K. and Siemion, W. and Taculad, R. and Van Horn, K. and Zdanadewic, M. and Chambliss, C. and Jones, J. and Sadler, M. and Tanner-Blasiar, M. and Bell, C. and Camper, N. and Devaskar, S. and Devaskar, U. and Horowitz, H. and Rogers, L. and Shannahan, R. and Silk, K. and Bermudez, Z. and Colon, R. and Frazer, T. and Martinez-Nieves, B. and Torres, J. and Vega, J. and Chan, M. and Cook, S. and Goland, R. and Greenberg, E. and Jules, N. and Montes, J. and Nelson, M. and Parra-Valencia, Z. and Schachner, H. and Softness, B. and Kiviniemi, M. and Suomenin, R. and Alexander, A. and Hyrckowian, E. and Nichol, L. and Trucco, M. and Karjalainen, E. and Louhio, T. and Sarnesto, A. and Valtonen, E. and Davydova, B. and Helander, S. and H{\"a}m{\"a}l{\"a}inen, J. and H{\"a}rk{\"o}nen, T. and Joutsjoki, L. and Kararic, M. and Latva-Koivisto, M. and L{\"o}nn, E. and Nurmi, T. and Ollila, I. and Rinkinen, J. and Ronkainen, M. and Tukiainen, H. and Cederl{\"o}f, A. and Kiikeri, M. and Tsupari, S. and Cheng, R. and Bryant, K. and Chan, Y. and Maezawa, Y. and Paltser, G. and Rasavi, R. and Tsui, H. and Winer, S. and Wu, P. and Yantha, J.
DOI: 10.1001/jama.2017.19826
2018

How to limit the progression of PTEN-deficient prostatic tumors?,Comment limiter la progression des tumeurs prostatiques déficientes en PTEN ?
Medecine/Sciences
Grelet, E. and Parisotto, M. and Metzger, D.
DOI: 10.1051/medsci/2018224
2018

¿-Secretase Inhibition Lowers Plasma Triglyceride-Rich Lipoproteins by Stabilizing the LDL Receptor
Cell Metabolism
Kim, K. and Goldberg, I.J. and Graham, M.J. and Sundaram, M. and Bertaggia, E. and Lee, S.X. and Qiang, L. and Haeusler, R.A. and Metzger, D. and Chambon, P. and Yao, Z. and Ginsberg, H.N. and Pajvani, U.B.
DOI: 10.1016/j.cmet.2018.02.010
2018

Adherence to a pediatric diabetic ketoacidosis protocol in children presenting to a tertiary care hospital
Pediatric Diabetes
Ronsley, R. and Islam, N. and Ronsley, C. and Metzger, D.L. and Panagiotopoulos, C.
DOI: 10.1111/pedi.12556
2018

PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo
Journal of Experimental Medicine
Parisotto, M. and Grelet, E. and Bizri, R.E. and Dai, Y. and Terzic, J. and Eckert, D. and Gargowitsch, L. and Bornert, J.-M. and Metzger, D.
DOI: 10.1084/jem.20171207
2018

Short-Term Fasting Reveals Amino Acid Metabolism as a Major Sex-Discriminating Factor in the Liver
Cell Metabolism
Della Torre, S. and Mitro, N. and Meda, C. and Lolli, F. and Pedretti, S. and Barcella, M. and Ottobrini, L. and Metzger, D. and Caruso, D. and Maggi, A.
DOI: 10.1016/j.cmet.2018.05.021
2018

WHO height charts can be safely substituted when calculating BP Z-scores in a North American clinic setting
Paediatrics and Child Health (Canada)
Rodd, C.J. and Metzger, D.L. and Sharma, A.K.
DOI: 10.1093/pch/pxx185
2018

Diabetes worsens skeletal muscle mitochondrial function, oxidative stress, and apoptosis after lower-limb ischemia-reperfusion: Implication of the RISK and SAFE Pathways?
Frontiers in Physiology
Pottecher, J. and Adamopoulos, C. and Lejay, A. and Bouitbir, J. and Charles, A.-L. and Meyer, A. and Singer, M. and Wolff, V. and Diemunsch, P. and Laverny, G. and Metzger, D. and Geny, B.
DOI: 10.3389/fphys.2018.00579
2018

Hypogonadotropic Hypogonadism in Males with Glycogen Storage Disease Type 1.
JIMD reports
DOI: 10.1007/8904_2016_38
PubMed: 28160246
02/2017

Re: Young adult patients with diabetes presenting to a university health clinic with depression and anxiety
British Columbia Medical Journal
Metzger, D.L.
2017

Nur77 deletion impairs muscle growth during developmental myogenesis and muscle regeneration in mice
PLoS ONE
Cortez-Toledo, O. and Schnair, C. and Sangngern, P. and Metzger, D. and ChaoThe, L.C.
DOI: 10.1371/journal.pone.0171268
2017

Gonad-related factors promote muscle performance gain during postnatal development in male and female mice
American Journal of Physiology - Endocrinology and Metabolism
Ueberschlag-Pitiot, V. and Stantzou, A. and Mess{\'e}ant, J. and Lemaitre, M. and Owens, D.J. and Noirez, P. and Roy, P. and Agbulut, O. and Metzger, D. and Ferry, A.
DOI: 10.1152/ajpendo.00446.2016
2017

Conditional expression of Ki-RasG12V in the mammary epithelium of transgenic mice induces estrogen receptor alpha (ERa)-positive adenocarcinoma
Oncogene
And{\`o}, S. and Malivindi, R. and Catalano, S. and Rizza, P. and Barone, I. and Panza, S. and Rovito, D. and Emprou, C. and Bornert, J.-M. and Laverny, G. and Metzger, D.
DOI: 10.1038/onc.2017.252
2017

Improved protocol for chromatin immunoprecipitation from mouse skeletal muscle
Journal of Visualized Experiments
Joshi, S. and Ueberschlag-Pitiot, V. and Metzger, D. and Davidson, I.
DOI: 10.3791/56504
2017

Androgen signaling negatively controls group 2 innate lymphoid cells
Journal of Experimental Medicine
Laffont, S. and Blanquart, E. and Savignac, M. and C{\'e}nac, C. and Laverny, G. and Metzger, D. and Girard, J.-P. and Belz, G.T. and Pelletier, L. and Seillet, C. and Gu{\'e}ry, J.-C.
DOI: 10.1084/jem.20161807
2017

Peroxisome proliferator-activated receptor gamma (PPAR¿) regulates lactase expression and activity in the gut
EMBO Molecular Medicine
Fumery, M. and Speca, S. and Langlois, A. and Davila, A.-M. and Dubuquoy, C. and Grauso, M. and Martin Mena, A. and Figeac, M. and Metzger, D. and Rousseaux, C. and Colombel, J.-F. and Dubuquoy, L. and Desreumaux, P. and Bertin, B.
DOI: 10.15252/emmm.201707795
2017

The histone code reader Spin1 controls skeletal muscle development
Cell Death and Disease
Greschik, H. and Duteil, D. and Messaddeq, N. and Willmann, D. and Arrigoni, L. and Sum, M. and Jung, M. and Metzger, D. and Manke, T. and G{\"u}nther, T. and Sch{\"u}le, R.
DOI: 10.1038/cddis.2017.468
2017

Moderate exercise allows for shorter recovery time in critical limb ischemia
Frontiers in Physiology
Lejay, A. and Laverny, G. and Paradis, S. and Schlagowski, A.-I. and Charles, A.-L. and Singh, F. and Zoll, J. and Thaveau, F. and Lonsdorfer, E. and Dufour, S. and Favret, F. and Wolff, V. and Metzger, D. and Chakfe, N. and Geny, B.
DOI: 10.3389/fphys.2017.00523
2017

Regeneration of fat cells from myofibroblasts during wound healing
Science
Plikus, M.V. and Guerrero-Juarez, C.F. and Ito, M. and Li, Y.R. and Dedhia, P.H. and Zheng, Y. and Shao, M. and Gay, D.L. and Ramos, R. and Hsi, T.-C. and Oh, J.W. and Wang, X. and Ramirez, A. and Konopelski, S.E. and Elzein, A. and Wang, A. and Supapannachart, R.J. and Lee, H.-L. and Lim, C.H. and Nace, A. and Guo, A. and Treffeisen, E. and Andl, T. and Ramirez, R.N. and Murad, R. and Offermanns, S. and Metzger, D. and Chambon, P. and Widgerow, A.D. and Tuan, T.-L. and Mortazavi, A. and Gupta, R.K. and Hamilton, B.A. and Millar, S.E. and Seale, P. and Pear, W.S. and Lazar, M.A. and Cotsarelis, G.
DOI: 10.1126/science.aai8792
2017

IFN-ß-induced reactive oxygen species and mitochondrial damage contribute to muscle impairment and inflammation maintenance in dermatomyositis
Acta Neuropathologica
Meyer, A. and Laverny, G. and Allenbach, Y. and Grelet, E. and Ueberschlag, V. and Echaniz-Laguna, A. and Lannes, B. and Alsaleh, G. and Charles, A.L. and Singh, F. and Zoll, J. and Lonsdorfer, E. and Maurier, F. and Boyer, O. and Gottenberg, J.-E. and Nicot, A.S. and Laporte, J. and Benveniste, O. and Metzger, D. and Sibilia, J. and Geny, B.
DOI: 10.1007/s00401-017-1731-9
2017

BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease
Nature Communications
Vieira, J.M. and Howard, S. and Villa Del Campo, C. and Bollini, S. and Dub{\'e}, K.N. and Masters, M. and Barnette, D.N. and Rohling, M. and Sun, X. and Hankins, L.E. and Gavriouchkina, D. and Williams, R. and Metzger, D. and Chambon, P. and Sauka-Spengler, T. and Davies, B. and Riley, P.R.
DOI: 10.1038/ncomms16034
2017

Regional differences in milk and complementary feeding patterns in infants participating in an international nutritional type 1 diabetes prevention trial
Maternal and Child Nutrition
Nucci, A.M. and Virtanen, S.M. and Sorkio, S. and B{\"a}rlund, S. and Cuthbertson, D. and Uusitalo, U. and Lawson, M.L. and Salonen, M. and Berseth, C.L. and Ormisson, A. and Lehtonen, E. and Savilahti, E. and Becker, D.J. and Dupr{\'e}, J. and Krischer, J.P. and Knip, M. and ?kerblom, H.K. and Mandrup-Poulsen, T. and Arjas, E. and L{\"a}{\"a}r{\"a}, E. and Lernmark, ?. and Schmidt, B. and Krischer, J.P. and ?kerblom, H.K. and Hyytinen, M. and Knip, M. and Koski, K. and Koski, M. and Pajakkala, E. and Salonen, M. and Cuthbertson, D. and Krischer, J.P. and Shanker, L. and Bradley, B. and Dosch, H.-M. and Dupr{\'e}, J. and Fraser, W. and Lawson, M. and Mahon, J.L. and Sermer, M. and Taback, S.P. and Becker, D. and Franciscus, M. and Nucci, A. and Palmer, J. and Pekkala, M. and Virtanen, S.M. and Catteau, J. and Howard, N. and Crock, P. and Craig, M. and Clarson, C.L. and Bere, L. and Thompson, D. and Metzger, D. and Kwan, J. and Stephure, D.K. and Pacaud, D. and Ho, J. and Schwarz, W. and Girgis, R. and Thompson, M. and Taback, S.P. and Catte, D. and Lawson, M.L. and Bradley, B. and Daneman, D. and Sermer, M. and Martin, M.-J. and Morin, V. and Frenette, L. and Ferland, S. and Sanderson, S. and Heath, K. and Huot, C. and Gonthier, M. and Thibeault, M. and Legault, L. and Laforte, D. and Cummings, E.A. and Scott, K. and Bridger, T. and Crummell, C. and Newman, S. and Houlden, R. and Breen, A. and Carson, G. and Kelly, S. and Sankaran, K. and Penner, M. and White, R.A. and Hardy Brown, K. and King, N. and Popkin, J. and Robson, L. and Coles, K. and Al Taji, E. and Aldhoon, I. and Mendlova, P. and Vavrinec, J. and Vosahlo, J. and Brazdova, L. and Venhacova, J. and Venhacova, P. and Cipra, A. and Tomsikova, Z. and Paterov{\'a}, P. and Gogelova, P. and Einberg, {\"U}. and Riikj{\"a}rv, M.-A. and Ormisson, A. and Tillmann, V. and Hirvasniemi, M. and Kleemola, P. and Parkkola, A. and Suomalainen, H. and J{\"a}rvenp{\"a}{\"a}, A.-L. and H{\"a}m{\"a}lainen, A.-M. and Haavisto, H. and Tenhola, S. and Lautala, P. and Salonen, P. and Aspholm, S. and Siljander, H. and Holm, C. and Ylitalo, S. and Lounamaa, R. and Nuuja, A. and Talvitie, T. and Lindstr{\"o}m, K. and Huopio, H. and Pesola, J. and Veijola, R. and Tapanainen, P. and Alar, A. and Korpela, P. and K{\"a}{\"a}r, M.-L. and Mustila, T. and Virransalo, R. and Nyk{\"a}nen, P. and Aschemeier, B. and Danne, T. and Kordonouri, O. and Krikovszky, D. and Mad{\'a}csy, L. and Khazrai, Y.M. and Maddaloni, E. and Pozzilli, P. and Mannu, C. and Songini, M. and de Beaufort, C. and Schierloh, U. and Bruining, J. and Basiak, A. and Wasikowa, R. and Ciechanowska, M. and Deja, G. and Jarosz-Chobot, P. and Szadkowska, A. and Cypryk, K. and Zawodniak-Szalapska, M. and Castano, L. and Gonzalez Frutos, T. and Oyarzabal, M. and Serrano-R{\'i}os, M. and Mart{\'i}nez-Larrad, M.T. and Hawkins, F.G. and Rodriguez Arnau, D. and Ludvigsson, J. and Smolinska Konefal, M. and Hanas, R. and Lindblad, B. and Nilsson, N.-{\"O}. and Fors, H. and Nordwall, M. and Lindh, A. and Edenwall, H. and Aman, J. and Johansson, C. and Gadient, M. and Schoenle, E. and Becker, D. and Daftary, A. and Klein, M.B. and Gilmour, C. and Palmer, J. and Malone, P. and Tanner-Blasiar, M. and White, N. and Devaskar, U. and Horowitz, H. and Rogers, L. and Colon, R. and Frazer, T. and Torres, J. and Goland, R. and Greenberg, E. and Nelson, M. and Schachner, H. and Softness, B. and Ilonen, J. and Trucco, M. and Nichol, L. and Savilahti, E. and H{\"a}rk{\"o}nen, T. and Knip, M. and Vaarala, O. and Luopaj{\"a}rvi, K. and Dosch, H.-M.
DOI: 10.1111/mcn.12354
2017

The nuclear receptor Nr4a1 acts as a microglia rheostat and serves as a therapeutic target in autoimmune-driven central nervous system inflammation
Journal of Immunology
Rothe, T. and Ipseiz, N. and Faas, M. and Lang, S. and Perez-Branguli, F. and Metzger, D. and Ichinose, H. and Winner, B. and Schett, G. and Kr{\"o}nke, G.
DOI: 10.4049/jimmunol.1600638
2017

Exome Sequencing and the Management of Neurometabolic Disorders.
The New England journal of medicine
DOI: 10.1056/nejmoa1515792
PubMed: 27276562
06/2016

Somatic mosaicism underlies X-linked acrogigantism syndrome in sporadic male subjects.
Endocrine-related cancer
DOI: 10.1530/erc-16-0082
PubMed: 26935837
04/2016

PGC-1beta, an essential transcriptional coregulator of the skeletal muscle,PQC-1ß, un corégulateur trasoiptionnel essentiel du muscle squelettique
Biofutur
Laverny, G. and Metzger, D.
2016

Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis
Journal of Clinical Investigation
Xie, T. and Liang, J. and Liu, N. and Huan, C. and Zhang, Y. and Liu, W. and Kumar, M. and Xiao, R. and D{'}Armiento, J. and Metzger, D. and Chambon, P. and Papaioannou, V.E. and Stripp, B.R. and Jiang, D. and Noble, P.W.
DOI: 10.1172/JCI85328
2016

Exome sequencing and the management of neurometabolic disorders
New England Journal of Medicine
Tarailo-Graovac, M. and Shyr, C. and Ross, C.J. and Horvath, G.A. and Salvarinova, R. and Ye, X.C. and Zhang, L.-H. and Bhavsar, A.P. and Lee, J.J.Y. and Dr{\"o}gem{\"o}ller, B.I. and Abdelsayed, M. and Alfadhel, M. and Armstrong, L. and Baumgartner, M.R. and Burda, P. and Connolly, M.B. and Cameron, J. and Demos, M. and Dewan, T. and Dionne, J. and Evans, A.M. and Friedman, J.M. and Garber, I. and Lewis, S. and Ling, J. and Mandal, R. and Mattman, A. and McKinnon, M. and Michoulas, A. and Metzger, D. and Ogunbayo, O.A. and Rakic, B. and Rozmus, J. and Ruben, P. and Sayson, B. and Santra, S. and Schultz, K.R. and Selby, K. and Shekel, P. and Sirrs, S. and Skrypnyk, C. and Superti-Furga, A. and Turvey, S.E. and Van Allen, M.I. and Wishart, D. and Wu, J. and Wu, J. and Zafeiriou, D. and Kluijtmans, L. and Wevers, R.A. and Eydoux, P. and Lehman, A.M. and Vallance, H. and Stockler-Ipsiroglu, S. and Sinclair, G. and Wasserman, W.W. and Van Karnebeek, C.D.
DOI: 10.1056/NEJMoa1515792
2016

Somatic mosaicism underlies X-linked acrogigantism syndrome in sporadic male subjects
Endocrine-Related Cancer
Daly, A.F. and Yuan, B. and Fina, F. and Caberg, J.-H. and Trivellin, G. and Rostomyan, L. and De Herder, W.W. and Naves, L.A. and Metzger, D. and Cuny, T. and Rabl, W. and Shah, N. and Jaffrain-Rea, M.-L. and Chiara Zatelli, M. and Faucz, F.R. and Castermans, E. and Nanni-Metellus, I. and Lodish, M. and Muhammad, A. and Palmeira, L. and Potorac, I. and Mantovani, G. and Neggers, S.J. and Klein, M. and Barlier, A. and Liu, P. and Ouafik, L. and Bours, V. and Lupski, J.R. and Stratakis, C.A. and Beckers, A.
DOI: 10.1530/ERC-16-0082
2016

SOX4 is essential for prostate tumorigenesis initiated by PTEN ablation
Cancer Research
Bilir, B. and Osunkoya, A.O. and Wiles, W.G. and Sannigrahi, S. and Lefebvre, V. and Metzger, D. and Spyropoulos, D.D. and Martin, W.D. and Moreno, C.S.
DOI: 10.1158/0008-5472.CAN-15-1868
2016

Muscle expression of a malonyl-CoA-insensitive carnitine palmitoyltransferase-1 protects mice against high-fat/high-sucrose diet-induced insulin resistance
American journal of physiology. Endocrinology and metabolism
Vavrova, E. and Lenoir, V. and Alves-Guerra, M.-C. and Denis, R.G. and Castel, J. and Esnous, C. and Dyck, J.R. and Luquet, S. and Metzger, D. and Bouillaud, F. and Prip-Buus, C.
DOI: 10.1152/ajpendo.00020.2016
2016

LMS tables for waist-circumference and waist-height ratio Z-scores in children aged 5-19 y in NHANES III: association with cardio-metabolic risks.
Pediatric research
DOI: 10.1038/pr.2015.160
PubMed: 26331767
12/2015

X-linked acrogigantism syndrome: clinical profile and therapeutic responses.
Endocrine-related cancer
DOI: 10.1530/erc-15-0038
PubMed: 25712922
06/2015

Use of growth charts in Canada: A National Canadian Paediatric Surveillance Program survey.
Paediatrics & child health
DOI: 10.1093/pch/20.4.185
PubMed: 26038634
05/2015

Managing type 1 diabetes in school: Recommendations for policy and practice.
Paediatrics & child health
PubMed: 25722642
2015

Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling
Journal of Clinical Investigation
Men{\'e}ndez-Guti{\'e}rrez, M.P. and R{\~o}szer, T. and Fuentes, L. and N{\'u}nez, V. and Escolano, A. and Redondo, J.M. and De Clerck, N. and Metzger, D. and Valledor, A.F. and Ricote, M.
DOI: 10.1172/JCI77186
2015

A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects
Cell Reports
Huet, T. and Laverny, G. and Ciesielski, F. and Moln{\'a}r, F. and Ramamoorthy, T.G. and Belorusova, A.Y. and Antony, P. and Potier, N. and Metzger, D. and Moras, D. and Rochel, N.
DOI: 10.1016/j.celrep.2014.12.045
2015

X-linked acrogigantism syndrome: Clinical profile and therapeutic responses
Endocrine-Related Cancer
Beckers, A. and Lodish, M.B. and Trivellin, G. and Rostomyan, L. and Lee, M. and Faucz, F.R. and Yuan, B. and Choong, C.S. and Caberg, J.-H. and Verrua, E. and Naves, L.A. and Cheetham, T.D. and Young, J. and Lysy, P.A. and Petrossians, P. and Cotterill, A. and Shah, N.S. and Metzger, D. and Castermans, E. and Ambrosio, M.R. and Villa, C. and Strebkova, N. and Mazerkina, N. and Gaillard, S. and Barra, G.B. and Casulari, L.A. and Neggers, S.J. and Salvatori, R. and Jaffrain-Rea, M.-L. and Zacharin, M. and Santamaria, B.L. and Zacharieva, S. and Lim, E.M. and Mantovani, G. and Zatelli, M.C. and Collins, M.T. and Bonneville, J.-F. and Quezado, M. and Chittiboina, P. and Oldfield, E.H. and Bours, V. and Liu, P. and De Herder, W.W. and Pellegata, N. and Lupski, J.R. and Daly, A.F. and Stratakis, C.A.
DOI: 10.1530/ERC-15-0038
2015

Orphan nuclear receptor NR4A1 regulates transforming growth factor-ß 2 signaling and fibrosis
Nature Medicine
Palumbo-Zerr, K. and Zerr, P. and Distler, A. and Fliehr, J. and Mancuso, R. and Huang, J. and Mielenz, D. and Tomcik, M. and F{\"u}rnrohr, B.G. and Scholtysek, C. and Dees, C. and Beyer, C. and Kr{\"o}nke, G. and Metzger, D. and Distler, O. and Schett, G. and Distler, J.H.W.
DOI: 10.1038/nm.3777
2015

Managing type 1 diabetes in school: Recommendations for policy and practice
Paediatrics and Child Health (Canada)
Lawrence, S.E. and Cummings, E.A. and Pacaud, D. and Lynk, A. and Metzger, D.L.
DOI: 10.1093/pch/20.1.35
2015

The transcriptional coregulator PGC-1ß controls mitochondrial function and anti-oxidant defence in skeletal muscles
Nature Communications
Ramamoorthy, T.G. and Laverny, G. and Schlagowski, A.-I. and Zoll, J. and Messaddeq, N. and Bornert, J.-M. and Panza, S. and Ferry, A. and Geny, B. and Metzger, D.
DOI: 10.1038/ncomms10210
2015

Managing type 1 diabetes in school: Recommendations for policy and practice,Prise en charge du diabète de type 1 à l'école : Recommandations de politiques et de pratiques
Paediatrics and Child Health (Canada)
Lawrence, S.E. and Cummings, E.A. and Pacaud, D. and Lynk, A. and Metzger, D.L.
DOI: 10.1093/pch/20.1.40
2015

The orphan nuclear receptor Nur77 Is a determinant of myofiber size and muscle mass in mice
Molecular and Cellular Biology
Tontonoz, P. and Cortez-Toledo, O. and Wroblewski, K. and Hong, C. and Lim, L. and Carranza, R. and Conneely, O. and Metzger, D. and Chao, L.C.
DOI: 10.1128/MCB.00715-14
2015

Patrolling monocytes control tumor metastasis to the lung
Science
Hanna, R.N. and Cekic, C. and Sag, D. and Tacke, R. and Thomas, G.D. and Nowyhed, H. and Herrley, E. and Rasquinha, N. and McArdle, S. and Wu, R. and Peluso, E. and Metzger, D. and Ichinose, H. and Shaked, I. and Chodaczek, G. and Biswas, S.K. and Hedrick, C.C.
DOI: 10.1126/science.aac9407
2015

VDR and gemini ligands
Oncotarget
Laverny, G. and Metzger, D.
DOI: 10.18632/oncotarget.5446
2015

A new murine model of sustainable and durable chronic critical limb ischemia fairly mimicking human pathology
European Journal of Vascular and Endovascular Surgery
Lejay, A. and Choquet, P. and Thaveau, F. and Singh, F. and Schlagowski, A. and Charles, A.-L. and Laverny, G. and Metzger, D. and Zoll, J. and Chakfe, N. and Geny, B.
DOI: 10.1016/j.ejvs.2014.12.010
2015

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers
Nature Genetics
Onengut-Gumuscu, S. and Chen, W.-M. and Burren, O. and Cooper, N.J. and Quinlan, A.R. and Mychaleckyj, J.C. and Farber, E. and Bonnie, J.K. and Szpak, M. and Schofield, E. and Achuthan, P. and Guo, H. and Fortune, M.D. and Stevens, H. and Walker, N.M. and Ward, L.D. and Kundaje, A. and Kellis, M. and Daly, M.J. and Barrett, J.C. and Cooper, J.D. and Deloukas, P. and Todd, J.A. and Wallace, C. and Concannon, P. and Rich, S.S. and Baskerville, T. and Bautista, N. and Bhatia, E. and Bhatia, V. and Hasan, K.B. and Bonnici, F. and Brodnicki, T. and Browning, B. and Cameron, F. and Chaichanwatanakul, K. and Cheung, P.T. and Colman, P. and Cotterill, A. and Couper, J. and Crock, P. and Cutfield, R. and Davis, T. and Dixon, P. and Donaghue, K. and Dowling, K. and Drury, P. and Dye, S. and Gellert, S. and Ghani, R.A. and Greer, R. and Han, X. and Harrison, L. and Homatopoulos, N. and Ji, L. and Jones, T. and Yin, L.K. and Kamaruddin, N.A. and Kanga, U. and Kanungo, A. and Kaur, G. and Kek, B. and Knowles, S. and Krebs, J. and Kumar, N. and Lee, Y.-J. and Li, X. and Liktimaskul, S. and Lloyd, M. and Loth, A. and Louey, A. and Mehra, N. and Merriman, T. and Min, L. and Morahan, G. and Moses, R. and Mraz, G. and Murphy, R. and Nicholson, I. and Panelo, A. and Poh, P. and Price, G. and Ratnam, N. and Sanjeevi, C. and Sedimbi, S. and Shen, S. and Ying, G.S. and Tait, B. and Tandon, N. and Thomas, A. and Varney, M. and Weerakulwattana, P. and Willis, J. and Akwo, E.A. and Albret, L. and Ampudia-Blasco, F. and Argente, J. and Avbelj, M. and Babadjanova, G. and Badenhoop, K. and Battelino, T. and Beilhack, G. and Bergholdt, R. and Bingley, P. and Boehm, B. and Bolidson, J. and Brismar, K. and Brorsson, C. and Carlson, J. and Castano, L. and Chandler, K. and Cherubini, V. and Cinek, O. and Cipponeri, E. and Collado, R.C. and de Leiva, A. and Dzivite, I. and Fagulha, A. and Balcells, M.F. and Cuartero, B.G. and Lacalle, C.G. and Guja, C. and Guti{\'e}rrez, P. and Hamou, A. and Hatziagelaki, E. and Heath, S. and Heilman, K. and Helmberg, W. and Hermon, O. and Hernandez, M. and Holzheu, I. and Hosszufalusi, N. and Ilonen, J. and Ionescu-Tirgoviste, C. and Johannesen, J. and Julier, C. and Kahles, H. and Kinalska, I. and Knip, M. and Kockum, I. and Kojo, E. and Kordonouri, O. and Kretowski, A. and Krikovszky, D. and Kurkhaus, A. and Kuzmicki, M. and Lavant, E. and Long, A. and Ludvigsson, J. and Madacsy, L. and Maliszewska, K. and Marga, M. and Martinez, M.P. and Mauricio, D. and Mazurkievicz, G. and Nerup, J. and Norkus, A. and Mogollon, F.J.N. and Okruszko, A. and Pettinari, C. and Phillip, M. and Pirags, V. and Pociot, F. and Pozzilli, P. and Racasan, R. and Raile, K. and Rappner, R. and Troyano, M.J.R. and Roep, B.O. and Rokni, S. and Rosinger, S. and Rubio-Cabezas, O. and Ruckgaber, C. and Satman, I. and Schober, E. and Seufert, J. and Sing, R. and Skrha, J. and Sobngwi, E. and Somerville, M. and Spinas, G. and Sumnik, Z. and Tilmann, V. and Undlien, D. and Urbanavicius, V. and der Auwera, B.V. and San Miguel, F.V. and Vazeo-Gerasimidi, A. and Velickiene, D. and W{\"a}gner, A. and Walter, M. and Williams, A. and Ziegler, A. and Agleham, M. and Aldrich, A. and Alemzadeh, R. and Alper, C. and Aly, T. and Anastassiou, D. and Arora, S. and Austin, A. and Becker, D. and Benoist, C. and Berka, N. and Bhatia, S. and Bonella, P. and Bottini, N. and Boyle, S. and Braden, J. and Brady, B. and Brickman, W. and Christensen, R. and Couch, R. and Counts, D. and Crandall, J. and Daniels, M. and Dolan, L. and Donaldson, D. and Doria, A. and Eisenbarth, G. and Elder, J. and El-Hajj, R. and Erlich, H. and Fain, P. and Fear, A.L. and Ferry, R. and Fiallo-Scharer, R. and Geraghty, D. and Ghosh, S. and Gitelman, S. and Godwin, M. and Goland, R. and Goodman, N. and Goodwin, G. and Gravely, J. and Greenbaum, C. and Gudgeon, C. and Gunville, F. and Hagopian, W. and Hakonarson, H. and Hansen, J. and Harrington, K. and Hassing, J. and Hilliker, W. and Hoffman, R. and Hulbert, E. and Izquierdo, R. and Jospe, N. and Kaiserman, K. and Kaufman, F. and Kim, S. and Kloos, E. and Kosoy, R. and Lane, J. and Lane, J. and Lawrence, J. and Levetan, C. and Levin, P. and Lipton, R. and Lonsdale, J. and Magnuson, V. and Marks, J. and Mayer-Davis, B. and McEvoy, R. and McIndoe, R. and Merkle, L. and Metzger, D. and Miao, D. and Mickelson, E. and Moonsamy, P. and Moore, W. and Moran, A. and Noble, J. and Olsem, G. and Orban, T. and Orlowski, C. and Paterson, A. and Pietropaolo, M. and Pihoker, C. and Polychronakos, C. and Post, J. and Postellon, D. and Pugliese, A. and Qu, HuiQi. and Quattrin, T. and Rappaport, M. and Raskin, P. and Risbeck, H. and Rodriguez, H. and Rodriguez, L. and Rogers, M. and Rubalcava, L. and Russell, B. and Schatz, D. and Scott, C. and She, J.-X. and Shilling, H. and Shulman, D. and Soyka, L. and Speiser, P. and Starkman, H. and Steck, A. and Stender, S. and Stratton, L. and Sur, D. and Taback, S. and Thrailkill, K. and Toth, E. and Trymbiski, P. and Tsalikian, E. and Vertachnik, K. and Wahlen, J. and Wang, X. and Weber, S. and Wherrett, D. and Willi, S. and Wilson, D. and Youkey, J. and Young, N. and Yu, L. and Zhao, L.P. and Zimmerman, D. and Adlem, E. and Allen, J. and Brown, J. and Clarke, P. and Clayton, D. and Coleman, G. and Cucca, F. and Davison, L. and Downes, K. and Duley, S. and Dunger, D. and Esposito, L. and Everett, V. and Field, S. and Hafler, J. and Hardy, M. and Harrison, D. and Harrison, I. and Hawkins, S. and Healy, B. and Hood, S. and Howell, S. and Howson, J. and Maisuria, M. and Meadows, W. and Mistry, T. and Nezhenstsev, S. and Nutland, S. and Ovington, N. and Plagnol, V. and Rainbow, D. and Rainbow, K. and Raj, S. and Schuilenburg, H. and Simpson, A. and Smink, L. and Smyth, D. and Taylor, N. and Tuomilehto, J. and Wicker, L. and Widmer, B. and Wilson, M. and Withers, H. and Yang, J. and Brown, M. and Crews, A. and Griffin, J. and Hall, M. and Harnish, T. and Hepler, J. and Hilner, J. and King, N. and Lohman, K. and Lu, L. and Nail, J. and Perdue, L. and Pierce, J. and Reboussin, D. and Rushing, S. and Sale, M. and Sides, E. and Snively, B. and Teuschler, H. and Theil, G. and Wagenknecht, L. and Williams, D. and Akolkar, B. and McKeon, C. and Nierras, C. and Thomson, E. and Altshuler, D. and Au, K. and Bain, S. and Barcellos, L. and Barral, S. and Becker, T. and Briggs, F. and Bronson, P. and de Bakker, P. and Devlin, B. and Eike, M.C. and Field, L. and Gabriel, S. and Garge, N. and Gaudieri, S. and Goldstein, B. and Gorodezky, C. and Hamon, S. and He, C. and Howson, J. and Humphreys, K. and James, I. and Lathrop, M. and Lie, B.A. and Li, D. and Mack, S. and McGinnis, R. and McKinnon, E. and McLaren, W. and Nolan, D. and Olsson, M. and Ott, J. and Owerbach, D. and Patterson, C. and Podolsky, R. and Ramsay, P. and Rangantah, V. and Risch, N. and Ronningen, K.S. and Shao, X. and Single, R. and Steffes, M. and Thomson, G. and Valdes, A.M. and Vandiedonck, C. and Whittaker, P. and Zhang, Q.
DOI: 10.1038/ng.3245
2015

Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation.
The New England journal of medicine
DOI: 10.1056/nejmoa1408028
PubMed: 25470569
12/2014

Autosomal dominant hypoparathyroidism caused by germline mutation in GNA11: phenotypic and molecular characterization.
The Journal of clinical endocrinology and metabolism
DOI: 10.1210/jc.2014-1029
PubMed: 24823460
09/2014

Hydrolyzed infant formula and early ß-cell autoimmunity: a randomized clinical trial.
JAMA
DOI: 10.1001/jama.2014.5610
PubMed: 24915259
06/2014

Clinical management of youth with gender dysphoria in Vancouver.
The Journal of pediatrics
DOI: 10.1016/j.jpeds.2013.10.068
PubMed: 24315505
04/2014

Provincial disparities of growth hormone coverage for young adult survivors of paediatric brain tumours across Canada.
Healthcare Policy
PubMed: 24726076
02/2014

B7-H4 expression in normal and diseased human islet ß cells.
Pancreas
DOI: 10.1097/mpa.0b013e31829695d2
PubMed: 24326367
01/2014

Extending World Health Organization weight-for-age reference curves to older children.
BMC pediatrics
DOI: 10.1186/1471-2431-14-32
PubMed: 24490896
2014

Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type
Developmental Cell
Rahmani, W. and Abbasi, S. and Hagner, A. and Raharjo, E. and Kumar, R. and Hotta, A. and Magness, S. and Metzger, D. and Biernaskie, J.
DOI: 10.1016/j.devcel.2014.10.022
2014

Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation
New England Journal of Medicine
Trivellin, G. and Daly, A.F. and Faucz, F.R. and Yuan, B. and Rostomyan, L. and Larco, D.O. and Schernthaner-Reiter, M.H. and Szarek, E. and Leal, L.F. and Caberg, J.-H. and Castermans, E. and Villa, C. and Dimopoulos, A. and Chittiboina, P. and Xekouki, P. and Shah, N. and Metzger, D. and Lysy, P.A. and Ferrante, E. and Strebkova, N. and Mazerkina, N. and Zatelli, M.C. and Lodish, M. and Horvath, A. and Bertollo De Alexandre, R. and Manning, A.D. and Levy, I. and Keil, M.F. and De La Luz Sierra, M. and Palmeira, L. and Coppieters, W. and Georges, M. and Naves, L.A. and Jamar, M. and Bours, V. and Wu, T.J. and Choong, C.S. and Bertherat, J. and Chanson, P. and Kamenicky, P. and Farrell, W.E. and Barlier, A. and Quezado, M. and Bjelobaba, I. and Stojilkovic, S.S. and Wess, J. and Costanzi, S. and Liu, P. and Lupski, J.R. and Beckers, A. and Stratakis, C.A.
DOI: 10.1056/NEJMoa1408028
2014

Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells
Nature Communications
Zhu, D. and H{\"o}lz, S. and Metzger, E. and Pavlovic, M. and Jandausch, A. and Jilg, C. and Galgoczy, P. and Herz, C. and Moser, M. and Metzger, D. and G{\"u}nther, T. and Arnold, S.J. and Sch{\"u}le, R.
DOI: 10.1038/ncomms4174
2014

Brg1 Loss Attenuates Aberrant Wnt-Signalling and Prevents Wnt-Dependent Tumourigenesis in the Murine Small Intestine
PLoS Genetics
Holik, A.Z. and Young, M. and Krzystyniak, J. and Williams, G.T. and Metzger, D. and Shorning, B.Y. and Clarke, A.R.
DOI: 10.1371/journal.pgen.1004453
2014

Acute effect of androgens on maximal force-generating capacity and electrically evoked calcium transient in mouse skeletal muscles
Steroids
Fraysse, B. and Vignaud, A. and Fane, B. and Schuh, M. and Butler-Browne, G. and Metzger, D. and Ferry, A.
DOI: 10.1016/j.steroids.2014.05.005
2014

LSD1 promotes oxidative metabolism of white adipose tissue
Nature Communications
Duteil, D. and Metzger, E. and Willmann, D. and Karagianni, P. and Friedrichs, N. and Greschik, H. and G{\"u}nther, T. and Buettner, R. and Talianidis, I. and Metzger, D. and Sch{\"u}le, R.
DOI: 10.1038/ncomms5093
2014

B7-H4 expression in normal and diseased human islet ß Cells
Pancreas
Cheung, S.S.C. and Ou, D. and Metzger, D.L. and Meloche, M. and Ao, Z. and Ng, S.S.W. and Owen, D. and Warnock, G.L.
DOI: 10.1097/MPA.0b013e31829695d2
2014

Clearance of PML/RARA-bound promoters suffice to initiate APL differentiation
Blood
Vitaliano-Prunier, A. and Halftermeyer, J. and Ablain, J. and De Reynies, A. and Peres, L. and Le Bras, M. and Metzger, D. and De Th{\'e}, H.
DOI: 10.1182/blood-2014-03-561852
2014

Mammary stem cells have myoepithelial cell properties
Nature Cell Biology
Prater, M.D. and Petit, V. and Alasdair Russell, I. and Giraddi, R.R. and Shehata, M. and Menon, S. and Schulte, R. and Kalajzic, I. and Rath, N. and Olson, M.F. and Metzger, D. and Faraldo, M.M. and Deugnier, M.-A. and Glukhova, M.A. and Stingl, J.
DOI: 10.1038/ncb3025
2014

Canadian endocrinologists' views on growth hormone replacement therapy in adult survivors of pediatric brain tumors following achievement of final height
British Columbia Medical Journal
Hasan, H. and Fuchsia Howard, A. and Metzger, D.L. and Gill, S. and Johnson, M. and Lo, A.C. and Goddard, K.
2014

Canadian endocrinologists’ views on growth hormone replacement therapy in adult survivors of pediatric brain tumours following achievement of final height
BC Medical Journal
2014

Canadian Pediatric Endocrine Group extension to WHO growth charts: Why bother?
Paediatrics & child health
PubMed: 24421695
06/2013

Case 2: Pimples in prepuberty: A five-year-old with an unusual cause of facial comedones.
Paediatrics & child health
DOI: 10.1093/pch/18.2.91a
PubMed: 24421664
02/2013

Endogenous expression of B7-H4 improves long-term murine islet allograft survival.
Transplantation
DOI: 10.1097/tp.0b013e318277229d
PubMed: 23192157
01/2013

Occurrence of slipped capital femoral epiphysis in children undergoing gonadotropin-releasing hormone agonist therapy for the treatment of central precocious puberty.
Hormone research in paediatrics
DOI: 10.1159/000351028
PubMed: 23859950
2013

Canadian Pediatric Endocrine Group extension to WHO growth charts: Why bother?
Paediatrics and Child Health (Canada)
Lawrence, S. and Cummings, E. and Chanoine, J.-P. and Metzger, D.L. and Palmert, M. and Sharma, A. and Rodd, C.
DOI: 10.1093/pch/18.6.295
2013

Endogenous expression of B7-H4 improves long-term murine islet allograft survival
Transplantation
Wang, X. and Hao, J. and Metzger, D.L. and Mui, A. and Lee, I.-F. and Akhoundsadegh, N. and Ao, Z. and Chen, L. and Ou, D. and Verchere, C.B. and Warnock, G.L.
DOI: 10.1097/TP.0b013e318277229d
2013

When genetic load does not correlate with phenotypic spectrum: lessons from the GnRH receptor (GNRHR).
The Journal of clinical endocrinology and metabolism
DOI: 10.1210/jc.2012-1264
PubMed: 22745237
09/2012

Blockade of both B7-H4 and CTLA-4 co-signaling pathways enhances mouse islet allograft survival.
Islets
DOI: 10.4161/isl.21239
PubMed: 22878670
2012

Generation of transplantable beta cells for patient-specific cell therapy
International Journal of Endocrinology
Wang, X. and Metzger, D.L. and Meloche, M. and Hao, J. and Ao, Z. and Warnock, G.L.
DOI: 10.1155/2012/414812
2012

B7-H4 treatment of t cells inhibits erk, jnk, p38, and akt activation
PLoS ONE
Wang, X. and Hao, J. and Metzger, D.L. and Ao, Z. and Chen, L. and Ou, D. and Verchere, C.B. and Mui, A. and Warnock, G.L.
DOI: 10.1371/journal.pone.0028232
2012

B7-H4 induces donor-specific tolerance in mouse islet allografts.
Cell transplantation
DOI: 10.3727/096368912x633815
PubMed: 21929869
2012

Early treatment of NOD mice with B7-H4 reduces the incidence of autoimmune diabetes.
Diabetes
DOI: 10.2337/db11-0375
PubMed: 21984581
12/2011

Novel use of F-DOPA PET/CT imaging in a child with paraganglioma/pheochromocytoma syndrome.
Pediatric radiology
DOI: 10.1007/s00247-011-2109-0
PubMed: 21567141
10/2011

Validation of diabetes case definitions using administrative claims data.
Diabetic medicine : a journal of the British Diabetic Association
DOI: 10.1111/j.1464-5491.2011.03238.x
PubMed: 21392063
04/2011

B7-H4 Pathway in Islet Transplantation and ß-Cell Replacement Therapies.
Journal of transplantation
DOI: 10.1155/2011/418902
PubMed: 22028949
2011

Early treatment of NOD mice with B7-H4 reduces the incidence of autoimmune diabetes
Diabetes
2011

Methylation profiling in individuals with Russell-Silver syndrome.
American journal of medical genetics. Part A
DOI: 10.1002/ajmg.a.33204
PubMed: 20082469
02/2010

Diabetic ketoacidosis in children and adolescents: an update and revised treatment protocol
BC Medical Journal
2010

Local expression of B7-H4 by recombinant adenovirus transduction in mouse islets prolongs allograft survival.
Transplantation
DOI: 10.1097/tp.0b013e318195e5fa
PubMed: 19307783
02/2009

Twenty-one additional cases of familial renal glucosuria: absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
DOI: 10.1093/ndt/gfn386
PubMed: 18622023
12/2008

Skewed X-chromosome inactivation is associated with primary but not secondary ovarian failure.
American journal of medical genetics. Part A
DOI: 10.1002/ajmg.a.31679
PubMed: 17431892
05/2007

Autosomal dominant pseudohypoaldosteronism type 1: mechanisms, evidence for neonatal lethality, and phenotypic expression in adults.
Journal of the American Society of Nephrology : JASN
DOI: 10.1681/asn.2005111188
PubMed: 16611713
05/2006

Mutations in fibroblast growth factor receptor 1 cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism.
Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.0600962103
PubMed: 16606836
04/2006

Suppression of human T-cell responses to beta-cells by activation of B7-H4 pathway.
Cell transplantation
DOI: 10.3727/000000006783981837
PubMed: 28871868
2006

Novel TRPM6 mutations in 21 families with primary hypomagnesemia and secondary hypocalcemia.
Journal of the American Society of Nephrology : JASN
DOI: 10.1681/asn.2004110989
PubMed: 16107578
10/2005

Regulation of TNF-related apoptosis-inducing ligand-mediated death-signal pathway in human beta cells by Fas-associated death domain and nuclear factor kappaB.
Human immunology
DOI: 10.1016/j.humimm.2005.03.009
PubMed: 16112027
07/2005

Autosomal dominant resistance to thyrotropin as a distinct entity in five multigenerational kindreds: clinical characterization and exclusion of candidate loci.
The Journal of clinical endocrinology and metabolism
DOI: 10.1210/jc.2005-0572
PubMed: 15870119
07/2005

Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial--Type 1.
Diabetes care
DOI: 10.2337/diacare.28.5.1068
PubMed: 15855569
05/2005

Synergistic inhibition of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human pancreatic beta cells by Bcl-2 and X-linked inhibitor of apoptosis.
Human immunology
DOI: 10.1016/j.humimm.2004.12.002
PubMed: 15784465
03/2005

Tumor necrosis factor-related apoptosis-inducing ligand and CD56 expression in patients with type 1 diabetes mellitus.
Pancreas
DOI: 10.1097/01.mpa.0000148515.77497.4b
PubMed: 15714132
03/2005

Oculorespiratory syndrome after influenza immunization in children.
The Pediatric infectious disease journal
DOI: 10.1097/01.inf.0000148924.89558.d5
PubMed: 15665712
01/2005

Long on QT and low on calcium.
Cardiology in the young
DOI: 10.1017/s1047951104006134
PubMed: 15680004
12/2004

Spectrum of HNF1A and GCK mutations in Canadian families with maturity-onset diabetes of the young (MODY).
Clinical and investigative medicine. Medecine clinique et experimentale
PubMed: 15305805
06/2004

Addison’s disease in a child with systemic lupus erythematosus
Pediatric Rheumatology Online Journal
2004

Current approaches to the prevention of type 1 diabetes
BC Medical Journal
2004

Telephone contact by a diabetes nurse educator improves hemoglobin A1c in adolescents with poorly controlled type 1 diabetes: a randomized controlled trial
Canadian Journal of Diabetes
2003

GCK and HNF1A mutations in Canadian families with maturity onset diabetes of the young (MODY).
Human mutation
DOI: 10.1002/humu.9090
PubMed: 12442280
12/2002

TNF-related apoptosis-inducing ligand death pathway-mediated human beta-cell destruction.
Diabetologia
DOI: 10.1007/s00125-002-0926-2
PubMed: 12488957
12/2002

Effects of insulin in relatives of patients with type 1 diabetes mellitus.
The New England journal of medicine
DOI: 10.1056/nejmoa012350
PubMed: 12037147
05/2002

beta-cell antigen-specific CD56(+) NKT cells from type 1 diabetic patients: autoaggressive effector T cells damage human CD56(+) beta cells by HLA-restricted and non-HLA-restricted pathways.
Human immunology
DOI: 10.1016/s0198-8859(02)00372-5
PubMed: 12039407
04/2002

Nine novel mutations in NR0B1 (DAX1) causing adrenal hypoplasia congenita.
Human mutation
DOI: 10.1002/humu.1236
PubMed: 11748852
12/2001

Spectrum of mutations of the AAAS gene in Allgrove syndrome: lack of mutations in six kindreds with isolated resistance to corticotropin.
The Journal of clinical endocrinology and metabolism
DOI: 10.1210/jc.86.11.5433
PubMed: 11701718
11/2001

High prevalence of celiac disease in patients with type 1 diabetes detected by antibodies to endomysium and tissue transglutaminase.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie
DOI: 10.1155/2001/640796
PubMed: 11381296
05/2001

Increased prevalence of celiac disease in girls with Turner syndrome detected using antibodies to endomysium and tissue transglutaminase.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie
DOI: 10.1155/2000/172914
PubMed: 11125180
12/2000

Cross-reactive rubella virus and glutamic acid decarboxylase (65 and 67) protein determinants recognised by T cells of patients with type I diabetes mellitus.
Diabetologia
DOI: 10.1007/s001250051373
PubMed: 10907121
06/2000

CD4+ and CD8+ T-cell clones from congenital rubella syndrome patients with IDDM recognize overlapping GAD65 protein epitopes. Implications for HLA class I and II allelic linkage to disease susceptibility.
Human immunology
DOI: 10.1016/s0198-8859(99)00037-3
PubMed: 10439311
08/1999

Sex-Steroid—Hormone Modulation of the Somatotropic Axis During Normal Male Puberty
Sex-Steroid Interactions with Growth Hormone
Daniel L. Metzger and James R. Kerrigan
DOI: 10.1007/978-1-4612-1546-2_4
1999

Antenatal treatment for classic 21-hydroxylase forms of congenital adrenal hyperplasia and the issues.
Genetics in medicine : official journal of the American College of Medical Genetics
PubMed: 11256677
1999

A provincial protocol for the treatment of diabetic ketoacidosis in children
BC Medical Journal
1998

Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth hormone)-insulin-like growth factor I axis in the human: evidence from pubertal pathophysiology and sex-steroid hormone replacement.
The Journal of Clinical Endocrinology and Metabolism
DOI: 10.1210/jcem.82.10.4317
PubMed: 9329378
10/1997

The short-term infusion of ovine corticotropin-releasing hormone does not alter luteinizing hormone concentrations in young adult men.
The Journal of Clinical Endocrinology and Metabolism
DOI: 10.1210/jcem.82.2.3782
PubMed: 9024279
02/1997

Estrogen and diclofenac sodium therapy in a prepubertal female with idiopathic juvenile osteoporosis.
Journal of pediatric endocrinology & metabolism : JPEM
DOI: 10.1515/jpem.1995.8.2.135
PubMed: 7584708
1995

Gonadal steroid hormone regulation of the somatotropic axis during puberty in humans Mechanisms of androgen and estrogen action.
Trends in endocrinology and metabolism: TEM
DOI: 10.1016/1043-2760(94)p3204-k
PubMed: 18407221
09/1994

Estrogen receptor blockade with tamoxifen diminishes growth hormone secretion in boys: evidence for a stimulatory role of endogenous estrogens during male adolescence.
The Journal of clinical endocrinology and metabolism
DOI: 10.1210/jcem.79.2.8045971
PubMed: 8045971
08/1994

Radiological case of the month. Case 2. Untreated chronic lymphocytic thyroiditis presenting as a pituitary mass and secondary hypocortisolism.
Archives of pediatrics & adolescent medicine
DOI: 10.1001/archpedi.1994.02170070059010
PubMed: 8019626
07/1994

The hepatopulmonary syndrome masquerading as pulmonary Langerhans-cell histiocytosis. Hepatopulmonary Syndrome Study Group.
Annals of internal medicine
DOI: 10.7326/0003-4819-121-1-199407010-00006
PubMed: 8198345
07/1994

Cholinergic and opioid involvement in release of growth hormone during exercise and recovery.
Journal of applied physiology (Bethesda, Md. : 1985)
PubMed: 8226493
08/1993

Characterization of pulsatile secretion and clearance of plasma cortisol in premature and term neonates using deconvolution analysis.
The Journal of Clinical Endocrinology and Metabolism
DOI: 10.1210/jcem.77.2.8345052
PubMed: 8345052
08/1993

Permanent neonatal diabetes mellitus and pancreatic exocrine insufficiency resulting from congenital pancreatic agenesis.
American journal of diseases of children (1960)
PubMed: 8506821
06/1993

Alterations in the neuroendocrine control of growth hormone secretion in the uremic rat.
Kidney international
DOI: 10.1038/ki.1993.146
PubMed: 8099633
05/1993

Androgen receptor blockade with flutamide enhances growth hormone secretion in late pubertal males: evidence for independent actions of estrogen and androgen.
The Journal of clinical endocrinology and metabolism
DOI: 10.1210/jcem.76.5.8496305
PubMed: 8496305
05/1993

Research

Current Project
I am currently involved in two multicenter trials involved with either the prevention or the early treatment of type 1 diabetes: the Diabetes TrialNet and the TRIGR (Trial to Reduce IDDM in the Genetically at Risk).

I also work closely with basic-science researchers at BCRI and at The Centre of Human Islet Transplant and Beta Cell Regeneration at VGH on an variety of studies related to the various immunological processes involved in the development of type 1 diabetes in humans.

Finally, I am a co-investigator in research evaluating a comprehensive provincial health care model for children with diabetes using existing population databases.

Honours & Awards

Outstanding Achievement Award, Canadian Diabetes Association — 2003

Family-Centred Care Award of Distinction, BCCH Partners in Care — 2003

The Noni MacDonald Award, Canadian Pediatric Society — 2014

Research Group Members

Karnjit Sarai, Volunteer