Overview

My research spans both type 1 and type 2 childhood diabetes.

The first aspect of my research relates to the prevention of type 2 diabetes (T2D) and its associated co-morbidities in youth with mental health conditions treated with atypical antipsychotic (AAP) medications. Since 2006, we have performed foundational research on AAPs and their metabolic sequelae in children / youth, established key partnerships and a platform for ongoing research, and created and implemented Canada’s first (and so far only) pediatric Provincial Mental Health Meta-bolic Program.

At the request of remote First Nations communities in BC, I have conducted diabetes screening and found high prevalence of pre-diabetes in youth residing in the region. This led to the program development of a modified, culturally appropriate Actions Schools! BC and Healthy Buddies program for implementation at three Tsimshian communities.

Further, in collaboration with Drs. Jean-Pierre Chanoine and Louise Masse, I led the evaluation of the Shapedown program at BC Children’s Hospital. Shapdown is a multi-disciplinary, well-defined weight treatment/management program for children and adolescents with a family-focused intervention. I led the evaluation of this program’s effect on BMI, insulin resistance, metabolic syndrome, and examined its effect on changes in psychological outcomes, nutrition, and physical activity.

In the realm of type 1 diabetes (T1D), I am the Clinical Core Leader within the CIHR New Emerging Team in Childhood Autoimmunity. Immune white cells, such as cytotoxic T lymphocytes (CTL) and natural killer (NK) cells protect us from infections by killing infected cells. Conversely, defects in their function or regulation lead to autoimmune diseases such as T1D. I collaborate with Dr. Rusung Tan in trying to understand the defects in these cells in order to develop new therapies and prevention strategies for this disease. In addition I am the regional site lead and Vancouver Affiliate PI for TrialNET, an international, multi-centre network dedicated to the study, prevention and treatment of T1D.

Publications

Stigma and Its Association With Glycemic Control and Hypoglycemia in Adolescents and Young Adults With Type 1 Diabetes: Cross-Sectional Study
Journal of Medical Internet Research
Anne-Sophie Brazeau and Meranda Nakhla and Michael Wright and Mélanie Henderson and Constadina Panagiotopoulos and Daniele Pacaud and Patricia Kearns and Elham Rahme and Deborah Da Costa and Kaberi Dasgupta
DOI: 10.2196/jmir.9432
04/2018

Diet and cardiometabolic side effects in children treated with second-generation antipsychotics
Clinical Nutrition ESPEN
Mikaela K. Barker and Carly M. Sable and Sarah E. Montgomery and Lorrie Chow and Timothy J. Green and Constadina Panagiotopoulos and Angela M. Devlin
DOI: 10.1016/j.clnesp.2017.09.013
02/2018

Stigma and Its Association With Glycemic Control and Hypoglycemia in Adolescents and Young Adults With Type 1 Diabetes: Cross-Sectional Study (Preprint)
Anne-Sophie Brazeau and Meranda Nakhla and Michael Wright and Mélanie Henderson and Constadina Panagiotopoulos and Daniele Pacaud and Patricia Kearns and Elham Rahme and Deborah Da Costa and Kaberi Dasgupta
DOI: 10.2196/preprints.9432
11/2017

Adherence to a pediatric diabetic ketoacidosis protocol in children presenting to a tertiary care hospital
Pediatric Diabetes
Rebecca Ronsley and Nazrul Islam and Claire Ronsley and Daniel L Metzger and Constadina Panagiotopoulos
DOI: 10.1111/pedi.12556
06/2017

Acute Kidney Injury in Children With Type 1 Diabetes Hospitalized for Diabetic Ketoacidosis
JAMA Pediatrics
Brenden E. Hursh and Rebecca Ronsley and Nazrul Islam and Cherry Mammen and Constadina Panagiotopoulos
DOI: 10.1001/jamapediatrics.2017.0020
05/2017

Does parental and adolescent participation in an e-health lifestyle modification intervention improves weight outcomes?
BioMed Central
DOI: 10.14288/1.0347221
2017

Stigma and Its Impact on Glucose Control Among Youth With Diabetes: Protocol for a Canada-Wide Study
JMIR Research Protocols
Anne-Sophie Brazeau and Meranda Nakhla and Michael Wright and Constadina Panagiotopoulos and Daniele Pacaud and Mélanie Henderson and Elham Rahme and Deborah Da Costa and Kaberi Dasgupta
DOI: 10.2196/resprot.6629
12/2016

Persistent Albuminuria in Children with Type 2 Diabetes: A Canadian Paediatric Surveillance Program Study.
Sellers EA and Hadjiyannakis S and Amed S and Dart AB and Dyck RF and Hamilton J and Langlois V and Panagiotopoulos C and Dean HJ
DOI: 10.1016/j.jpeds.2015.09.042
PubMed: 26470688
10/2015

Adrenal Suppression in Children Treated With Oral Viscous Budesonide for Eosinophilic Esophagitis.
Harel S and Hursh BE and Chan ES and Avinashi V and Panagiotopoulos C
DOI: 10.1097/MPG.0000000000000848
PubMed: 25950088
08/2015

Individual and household predictors of adolescents' adherence to a web-based intervention.
Mâsse LC and Watts AW and Barr SI and Tu AW and Panagiotopoulos C and Geller J and Chanoine JP
DOI: 10.1007/s12160-014-9658-z
PubMed: 25270826
06/2015

Obesity and arterial stiffness in children: systematic review and meta-analysis.
Cote AT and Phillips AA and Harris KC and Sandor GG and Panagiotopoulos C and Devlin AM
DOI: 10.1161/ATVBAHA.114.305062
PubMed: 25633314
04/2015

Effectiveness of an educational handbook in improving psychiatry resident knowledge of second-generation antipsychotics.
Gibson J and Nguyen D and Davidson J and Panagiotopoulos C
DOI: 10.1007/s40596-014-0177-9
PubMed: 24994542
04/2015

Interaction between the Val158Met catechol-O-methyltransferase gene variant and second-generation antipsychotic treatment on blood pressure in children.
Cote AT and Panagiotopoulos C and Devlin AM
DOI: 10.1038/tpj.2014.35
PubMed: 25048416
02/2015

Metabolic side effects and pharmacogenetics of second-generation antipsychotics in children.
Devlin AM and Panagiotopoulos C
DOI: 10.2217/pgs.15.55
PubMed: 26107755
2015

Ensuring the Safety of Children Treated with Second-Generation Antipsychotics
The Science and Ethics of Antipsychotic Use in Children
Rebecca Ronsley and Lorrie Chow and Kristine Kuss and Jana Davidson and Constadina Panagiotopoulos
DOI: 10.1016/b978-0-12-800016-8.00004-0
2015

Increased risk of obesity and metabolic dysregulation following 12 months of second-generation antipsychotic treatment in children: A prospective cohort study
Canadian Journal of Psychiatry
Ronsley, R. and Nguyen, D. and Davidson, J. and Panagiotopoulos, C.
2015

Ensuring the Safety of Children Treated with Second-Generation Antipsychotics
The Science and Ethics of Antipsychotic Use in Children
Ronsley, R. and Chow, L. and Kuss, K. and Davidson, J. and Panagiotopoulos, C.
DOI: 10.1016/B978-0-12-800016-8.00004-0
2015

Canadian Paediatric Society 92nd Annual Conference: Abstracts.
2015

Initial screening of children treated with second-generation antipsychotics points to an association between physical activity and insulin resistance.
Cote AT and Devlin AM and Panagiotopoulos C
DOI: 10.1123/pes.2014-0076
PubMed: 25372380
11/2014

Quetiapine treatment in youth is associated with decreased insulin secretion.
Ngai YF and Sabatini P and Nguyen D and Davidson J and Chanoine JP and Devlin AM and Lynn FC and Panagiotopoulos C
DOI: 10.1097/JCP.0000000000000118
PubMed: 24633003
06/2014

Rising antipsychotic prescriptions for children and youth: cross-sectoral solutions for a multimodal problem.
Di Pietro N and Illes J and Canadian Working Group on Antipsychotic Medications and Children
DOI: 10.1503/cmaj.131604
PubMed: 24664655
06/2014

Case 2: Generalized swelling in a child with newly diagnosed diabetes mellitus.
Hursh BE and Dedhar A and Panagiotopoulos C
PubMed: 24855422
05/2014

Case 2: Generalized swelling in a child with newly diagnosed diabetes mellitus
Paediatrics & Child Health
Brenden E Hursh and Alysha Dedhar and Constadina Panagiotopoulos
DOI: 10.1093/pch/19.5.233-b
05/2014

Cardiovascular risk factors and health behaviours in elementary school-age Inuvialuit and Gwich'in children
Paediatrics & Child Health
Constadina Panagiotopoulos and Duc Nguyen and Jane Smith
DOI: 10.1093/pch/19.5.256
05/2014

Cardiovascular risk factors and health behaviours in elementary school-age Inuvialuit and Gwich'in children.
Panagiotopoulos C and Nguyen D and Smith J
PubMed: 24855429
05/2014

Cardiovascular risk factors and health behaviours in elementary school-age Inuvialuit and Gwich'in children
Paediatrics and Child Health (Canada)
Panagiotopoulos, C. and Nguyen, D. and Smith, J.
2014

Case 2: Generalized swelling in a child with newly diagnosed diabetes mellitus
Paediatrics and Child Health (Canada)
Hursh, B.E. and Dedhar, A. and Panagiotopoulos, C.
2014

Childhood obesity and cardiovascular dysfunction.
Cote AT and Harris KC and Panagiotopoulos C and Sandor GG and Devlin AM
DOI: 10.1016/j.jacc.2013.07.042
PubMed: 23954339
10/2013

Healthy Buddies™ reduces body mass index z-score and waist circumference in Aboriginal children living in remote coastal communities.
Ronsley R and Lee AS and Kuzeljevic B and Panagiotopoulos C
DOI: 10.1111/josh.12072
PubMed: 23879779
09/2013

A population-based study of antipsychotic prescription trends in children and adolescents in British Columbia, from 1996 to 2011.
Ronsley R and Scott D and Warburton WP and Hamdi RD and Louie DC and Davidson J and Panagiotopoulos C
PubMed: 23768264
06/2013

Type 2 diabetes in children and adolescents.
Canadian Diabetes Association Clinical Practice Guidelines Expert Committee and Panagiotopoulos C and Riddell MC and Sellers EA
DOI: 10.1016/j.jcjd.2013.01.043
PubMed: 24070942
04/2013

A population-based study of antipsychotic prescription trends in children and adolescents in British Columbia, from 1996 to 2011
Canadian Journal of Psychiatry
Ronsley, R. and Scott, D. and Warburton, W.P. and Hamdi, R.D. and Louie, D.C. and Davidson, J. and Panagiotopoulos, C.
2013

Le diabète de type 2 chez les enfants et les adolescents
Canadian Journal of Diabetes
Panagiotopoulos, C. and Riddell, M.C. and Sellers, E.A.C.
DOI: 10.1016/j.jcjd.2013.07.039
2013

Health Information Preference among Youth and Caregivers related to Second-Generation Antipsychotic Treatment.
Xu Y and Nguyen D and Davidson J and Panagiotopoulos C
PubMed: 23133465
11/2012

[Not Available].
Pringsheim T and Panagiotopoulos C and Davidson J and Ho J
PubMed: 24082813
10/2012

[Not Available].
Ho J and Panagiotopoulos C and McCrindle B and Grisaru S and Pringsheim T
PubMed: 24082815
10/2012

Differing clinical features in Aboriginal vs. non-Aboriginal children presenting with type 2 diabetes.
Amed S and Hamilton JK and Sellers EA and Panagiotopoulos C and Hadjiyannakis S and Shah BR and Booth GL and Laubscher TA and Dannenbaum D and Dean H
DOI: 10.1111/j.1399-5448.2012.00859.x
PubMed: 22369184
09/2012

Metabolic monitoring training program implementation in the community setting was associated with improved monitoring in second-generation antipsychotic-treated children.
Ronsley R and Rayter M and Smith D and Davidson J and Panagiotopoulos C
PubMed: 22546061
05/2012

Waist circumference is a sensitive screening tool for assessment of metabolic syndrome risk in children treated with second-generation antipsychotics.
Panagiotopoulos C and Ronsley R and Kuzeljevic B and Davidson J
PubMed: 22296966
01/2012

The impact of Action Schools! BC on the health of Aboriginal children and youth living in rural and remote communities in British Columbia.
Tomlin D and Naylor PJ and McKay H and Zorzi A and Mitchell M and Panagiotopoulos C
DOI: 10.3402/ijch.v71i0.17999
PubMed: 22456048
2012

Cardiometabolic risk and the MTHFR C677T variant in children treated with second-generation antipsychotics.
Devlin AM and Ngai YF and Ronsley R and Panagiotopoulos C
DOI: 10.1038/tp.2011.68
PubMed: 22832733
2012

The impact of Action Schools! BC on the health of Aboriginal children and youth living in rural and remote communities in British Columbia.
International journal of circumpolar health
Tomlin, D. and Naylor, P.J. and McKay, H. and Zorzi, A. and Mitchell, M. and Panagiotopoulos, C.
2012

Health information preference among youth and caregivers related to second-generation antipsychotic treatment
Journal of the Canadian Academy of Child and Adolescent Psychiatry
Xu, Y. and Nguyen, D. and Davidson, J. and Panagiotopoulos, C.
2012

Metabolic monitoring training program implementation in the community setting was associated with improved monitoring in second-generation antipsychotic-treated children
Canadian Journal of Psychiatry
Ronsley, R. and Rayter, M. and Smith, D. and Davidson, J. and Panagiotopoulos, C.
2012

Prescribing second-generation antipsychotic medications: Practice guidelines for general practitioners
British Columbia Medical Journal
Horn, M. and Procyshyn, R.M. and Warburton, W.P. and Tregillus, V. and Cavers, W. and Davidson, J. and Panagiotopoulos, C.
2012

Waist circumference is a sensitive screening tool for assessment of metabolic syndrome risk in children treated with second-generation antipsychotics
Canadian Journal of Psychiatry
Panagiotopoulos, C. and Ronsley, R. and Kuzeljevic, B. and Davidson, J.
2012

Severe amiodarone-induced hypothyroidism in an infant
Pediatric Critical Care Medicine
Karen Trudel and Shubhayan Sanatani and Constadina Panagiotopoulos
DOI: 10.1097/pcc.0b013e3181e2a388
01/2011

The Centre for Healthy Weights-Shapedown BC: A family-centered, multidisciplinary program that reduces weight gain in obese children over the short-term
International Journal of Environmental Research and Public Health
Panagiotopoulos, C. and Ronsley, R. and Al-Dubayee, M. and Brant, R. and Kuzeljevic, B. and Rurak, E. and Cristall, A. and Marks, G. and Sneddon, P. and Hinchliffe, M. and Chanoine, J.-P. and Mâsse, L.C.
DOI: 10.3390/ijerph8124662
2011

Treatment recommendations for extrapyramidal side effects associated with second-generation antipsychotic use in children and youth
Paediatrics and Child Health
Pringsheim, T. and Doja, A. and Belanger, S. and Patten, S. and Casselman, L. and Davidson, J. and Grisaru, S. and Ho, J. and Jabbal, R. and MacKean, G. and McCrindle, B. and McLennan, J. and Palda, V. and Panagiotopoulos, C. and Pearce, M. and Ponesse, J. and Thomas, R. and Waheed, W. and Wilkes, C.
2011

Evidence-based recommendations for monitoring safety of second-generation antipsychotics in children and youth
Paediatrics and Child Health
Pringsheim, T. and Panagiotopoulos, C. and Davidson, J. and Ho, J. and Belanger, S. and Casselman, L. and Doja, A. and Grisaru, S. and Jabbal, R. and MacKean, G. and McCrindle, B. and McLennan, J. and Palda, V. and Patten, S. and Pearce, M. and Ponesse, J. and Thomas, R. and Waheed, W. and Wilkes, C.
2011

Management recommendations for metabolic complications associated with second-generation antipsychotic use in children and youth
Paediatrics and Child Health
Ho, J. and Panagiotopoulos, C. and McCrindle, B. and Grisaru, S. and Pringsheim, T. and Belanger, S. and Casselman, L. and Davidson, J. and Doja, A. and Jabbal, R. and MacKean, G. and McLennan, J. and Palda, V. and Patten, S. and Pearce, M. and Ponesse, J. and Thomas, R. and Waheed, W. and Wilkes, C.
2011

Evidence-based recommendations for monitoring safety of second generation antipsychotics in children and youth
Journal of the Canadian Academy of Child and Adolescent Psychiatry
Pringsheim, T. and Panagiotopoulos, C. and Davidson, J. and Ho, J.
2011

Risk factors for medication-induced diabetes and type 2 diabetes
Journal of Pediatrics
Amed, S. and Dean, H. and Sellers, E.A.C. and Panagiotopoulos, C. and Shah, B.R. and Booth, G.L. and Laubscher, T.A. and Dannenbaum, D. and Hadjiyannakis, S. and Hamilton, J.K.
DOI: 10.1016/j.jpeds.2011.01.017
2011

Management recommendations for metabolic complications associated with second generation antipsychotic use in children and youth
Journal of the Canadian Academy of Child and Adolescent Psychiatry
Ho, J. and Panagiotopoulos, C. and Mccrindle, B. and Grisaru, S. and Pringsheim, T.
2011

Barriers and facilitators to implementation of a metabolic monitoring protocol in hospital and community settings for second-generation antipsychotic-treated youth
Journal of the Canadian Academy of Child and Adolescent Psychiatry
Ronsley, R. and Raghuram, K. and Davidson, J. and Panagiotopoulos, C.
2011

Natural killer cells from children with type 1 diabetes have defects in NKG2D-dependent function and signaling
Diabetes
Qin, H. and Lee, I.-F. and Panagiotopoulos, C. and Wang, X. and Chu, A.D. and Utz, P.J. and Priatel, J.J. and Tan, R.
DOI: 10.2337/db09-1706
2011

Erratum: Impaired proinsulin processing is a characteristic of transplanted islets (American Journal of Transplantation (2009) 9 (2119-2125) (doi: 10.1111/j.1600-6143.2009.02740.x))
American Journal of Transplantation
Klimek, A.M. and Soukhatcheva, G. and Thompson, D.M. and Warnock, G.L. and Salehi, M. and Rilo, H. and DAlessio, D. and Meneilly, G.S. and Panagiotopoulos, C. and Verchere, C.B.
DOI: 10.1111/j.1600-6143.2010.03435.x
2011

Severe amiodarone-induced hypothyroidism in an infant.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Trudel, K. and Sanatani, S. and Panagiotopoulos, C.
DOI: 10.1097/PCC.0b013e3181e2a388
2011

Cutting edge: Increased IL-17-secreting T cells in children with new-onset type 1 diabetes
Journal of Immunology
Marwaha, A.K. and Crome, S.Q. and Panagiotopoulos, C. and Berg, K.B. and Qin, H. and Ouyang, Q. and Xu, L. and Priatel, J.J. and Levings, M.K. and Tan, R.
DOI: 10.4049/jimmunol.1001860
2010

Engaging families in research to determine health literacy needs related to the use of second-generation antipsychotics in children and adolescents
Journal of the Canadian Academy of Child and Adolescent Psychiatry
Chovil, N. and Panagiotopoulos, C.
2010

Primary pulmonary arterial hypertension and autoimmune polyendocrine syndrome in a pediatric patient
Pediatric Cardiology
Alghamdi, M.H. and Steinraths, M. and Panagiotopoulos, C. and Potts, J.E. and Sandor, G.G.S.
DOI: 10.1007/s00246-010-9704-y
2010

First do no harm: Promoting an evidence-based approach to atypical antipsychotic use in children and adolescents
Journal of the Canadian Academy of Child and Adolescent Psychiatry
Panagiotopoulos, C. and Ronsley, R. and Elbe, D. and Davidson, J. and Smith, D.H.
2010

Habitual moderate-to-vigorous physical activity is inversely associated with insulin resistance in canadian first nations youth
Pediatric Exercise Science
Mitchell, M.S. and Gaul, C.A. and Naylor, P.-J. and Panagiotopoulos, C.
2010

Implementing a whole school physical activity and healthy eating model in rural and remote first nations schools: a process evaluation of action schools! BC.
Rural and remote health
Naylor, P.J. and Scott, J. and Drummond, J. and Bridgewater, L. and McKay, H.A. and Panagiotopoulos, C.
2010

Type 2 diabetes, medication-induced diabetes, and monogenic diabetes in Canadian children: A prospective national surveillance study
Diabetes Care
Amed, S. and Dean, H.J. and Panagiotopoulos, C. and Sellers, E.A.C. and Hadjiyannakis, S. and Laubscher, T.A. and Dannenbaum, D. and Shah, B.R. and Booth, G.L. and Hamilton, J.K.
DOI: 10.2337/dc09-1013
2010

Increased prevalence of obesity and glucose intolerance in youth treated with second-generation antipsychotic medications
Canadian Journal of Psychiatry
Panagiotopoulos, C. and Ronsley, R. and Davidson, J.
2009

A naturalistic study of predictors and risks of atypical antipsychotic use in an attention-deficit/hyperactivity disorder clinic
Journal of Child and Adolescent Psychopharmacology
Weiss, M. and Panagiotopoulos, C. and Giles, L. and Gibbins, C. and Kuzeljevic, B. and Davidson, J. and Harrison, R.
DOI: 10.1089/cap.2009.0050
2009

Impaired proinsulin processing is a characteristic of transplanted islets
American Journal of Transplantation
Klimek, A.M. and Soukhatcheva, G. and Thompson, D.M. and Warnock, G.L. and Salehi, M. and Rilo, H. and D'Alessio, D. and Meneilly, G.S. and Panagiotopoulos, C. and Verchere, C.B.
DOI: 10.1111/j.1600-6143.2009.02740.x
2009

Prevalence of type 2 diabetes, obesity and the metabolic syndrome among Canadian First Nations children in a remote Pacific coast community
Paediatrics and Child Health
Wahi, G. and Zorzi, A. and Macnab, A. and Panagiotopoulos, C.
2009

Prevalence of impaired glucose tolerance and the components of metabolic syndrome in Canadian Tsimshian Nation youth.
Canadian journal of rural medicine : the official journal of the Society of Rural Physicians of Canada = Journal canadien de la médecine rurale : le journal officiel de la Société de médecine rurale du Canada
Zorzi, A. and Wahi, G. and Macnab, A.J. and Panagiotopoulos, C.
2009

Aircraft Loading and Freezer Enhancements: Lessons for Medical Research in Remote Communities
Air Medical Journal
Gagnon, R. and Gagnon, F. and Panagiotopoulos, C.
DOI: 10.1016/j.amj.2008.04.001
2008

Cooking for your life! A family-centered community-based nutrition education program for youth with type 2 diabetes or impaired glucose tolerance
Canadian Journal of Diabetes
Nichol, H. and Retallack, J. and Panagiotopoulos, C.
2008

Is School-based Screening for Type 2 Diabetes in Youth Warranted in Canada?
Canadian Journal of Diabetes
Constadina Panagiotopoulos
DOI: 10.1016/s1499-2671(07)12005-0
01/2007

Diabetes screening of children in a remote First Nations community on the west coast of Canada: challenges and solutions.
Rural and remote health
Panagiotopoulos, C. and Rozmus, J. and Gagnon, R.E. and Macnab, A.J.
2007

Is school-based screening for type 2 diabetes in youth warranted in Canada?
Canadian Journal of Diabetes
Panagiotopoulos, C.
2007

Skewed X-chromosome inactivation is associated with primary but not secondary ovarian failure
American Journal of Medical Genetics, Part A
Bretherick, K.L. and Metzger, D.L. and Chanoine, J.-P. and Panagiotopoulos, C. and Watson, S.K. and Lam, W.L. and Fluker, M.R. and Brown, C.J. and Robinson, W.P.
DOI: 10.1002/ajmg.a.31679
2007

Recognition of HLA class I-restricted ß-cell epitopes in type 1 diabetes
Diabetes
Ouyang, Q. and Standifer, N.E. and Qin, H. and Gottlieb, P. and Verchere, C.B. and Nepom, G.T. and Tan, R. and Panagiotopoulos, C.
DOI: 10.2337/db06-0065
2006

Identification of novel HLA-A*0201-restricted epitopes in recent-onset type 1 diabetic subjects and antibody-positive relatives
Diabetes
Standifer, N.E. and Ouyang, Q. and Panagiotopoulos, C. and Verchere, C.B. and Tan, R. and Greenbaum, C.J. and Pihoker, C. and Nepom, G.T.
DOI: 10.2337/db06-0066
2006

Detection and enumeration of beta cell-specific cytotoxic T lymphocytes in type 1 diabetes: Is disease prediction possible?
Canadian Journal of Diabetes
Trudeau, J.D. and Panagiotopoulos, C. and Verchere, C.B. and Tan, R.
2005

Current approaches for the prediction and identification of CD8 T-cell epitopes in type 1 diabetes
Current Opinion in Endocrinology and Diabetes
Standifer, N.E. and Panagiotopoulos, C. and Tan, R.
2005

T-cell epitopes in type 1 diabetes
Current Diabetes Reports
Constadina Panagiotopoulos and Jacqueline D. Trudeau and Rusung Tan
DOI: 10.1007/s11892-004-0062-0
04/2004

Type 2 diabetes in children and adolescents
British Columbia Medical Journal
Panagiotopoulos, C.
2004

T-cell epitopes in type 1 diabetes
Current Diabetes Reports
Panagiotopoulos, C. and Trudeau, J.D. and Tan, R.
2004

Weekly Telephone Contact by a Diabetes Educator in Adolescents with Type 1 Diabetes
Canadian Journal of Diabetes
Panagiotopoulos, C. and Preston, J.M. and Stewart, L.L. and Metzger, D.L. and Chanoine, J.-P.
2003

Identification of a ß-Cell-Specific HLA Class I Restricted Epitope in Type 1 Diabetes
Diabetes
Panagiotopoulos, C. and Qin, H. and Tan, R. and Verchere, C.B.
DOI: 10.2337/diabetes.52.11.2647
2003

Electrocardiographic findings in adolescents with eating disorders
Pediatrics
Panagiotopoulos, C. and McCrindle, B.W. and Hick, K. and Katzman, D.K.
2000

ELECTROCARDIOGRAPHIC CORRELATES OF CLINICAL STATUS IN ADOLESCENTS WITH EATING DISORDERS--A CASE-CONTROL STUDY. † 29
Pediatric Research
Constadina Panagiotopoulos and Brian W. McCrindle and Katherine Hick and Debra K. Katzman
DOI: 10.1203/00006450-199704001-00050
04/1997

Newborn complications after intrapartum asphyxia with metabolic acidosis in the preterm fetus
American Journal of Obstetrics and Gynecology
Low, J.A. and Panagiotopoulos, C. and Derrick, E.J.
DOI: 10.1016/0002-9378(95)90003-9
1995

Validity of newborm oscillometric blood pressure
Clinical and Investigative Medicine
Low, J.A. and Panagiotopoulos, C. and Smith, J.T. and Tang, W. and Derrick, E.J.
1995

Newborn complications after intrapartum asphyxia with metabolic acidosis in the term fetus
American Journal of Obstetrics and Gynecology
James A. Low and Constadina Panagiotopoulos and E.Jane Derrick
DOI: 10.1016/s0002-9378(94)70101-6
04/1994

Newborn complications after intrapartum asphyxia with metabolic acidosis in the term fetus
American Journal of Obstetrics and Gynecology
Low, J.A. and Panagiotopoulos, C. and Derrick, E.J.
1994

Research

Autoimmunity in Type 1 Diabetes
Type 1 diabetes mellitus arises from an autoimmune process directed against pancreatic beta cells in both humans and non-obese diabetic (NOD) mice. The destruction of beta cells is understood to be mediated by CD8+ cytotoxic T lymphocytes (CTL), though many other cell types are beginning to emerge as additional candidates in the disease progression. In collaboration with Dr. Rusung Tan, we are examining NK cells and subsets of proinflammatory T cells implicated in T1D. With Dr. Bruce Verchere, we are studying the mechanisms of beta cell failure in islet transplantation.

Type 2 Diabetes Screening and Prevention in Remote First Nations Communities
Through longstanding relationships with three Tsimshian communities in BC and at their request, we have conducted diabetes screening and determined a high prevalence of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) among youth residing in the region. This was the impetus behind the modification, implementation and evaluation of Action Schools! BC and Healthy Buddies programs for the communities’ specific settings. We are currently expanding this modified program to a community in Nunavut at their request.

Metabolic Effects of Atypical Antipsychotics in Pediatric Population
In BC, mental illness occurs in 15% of children and adolescents, many of whom are treated with atypical antipsychotics (AAPs). To evaluate the metabolic sequelae of AAP use in youth, we have since 2006 conducted a retrospective chart review at BC Children’s Hospital (BCCH), developed a draft Metabolic Assessment and Monitoring Tool, and undertaken various knowledge translation initiatives at BCCH, Vancouver Coastal Health and beyond. These include the development of Healthy Living Toolkit, implementation of Metabolic Monitoring Tool in community mental health teams and the first Pediatric Provincial Mental Health Metabolic Program. We seek to have an immediate impact to improve the health of AAP-treated youth by enhancing the knowledge base of healthcare providers and families. This work is funded by multiple stakeholders, including the Lawson Foundation and the BC Provincial Health Services Authority.

Honours & Awards

Abbott Nutrition Young Investigator Award in Research, Western Society for Pediatric Research – 2013

Leading Practice Award, Accreditation Canada – 2013

Speaking of Food and Healthy Living Award, Dietitians of Canada – 2012

Research Group Members

Kimberley Chong, Research Assistant
Amanda Henderson, Endocrinology & Diabetes Unit
Michelle Huebert, Research Assistant
Madeleine Tan, Undergraduate Student