Dewi Schrader
MHSc, MBBS, FRCPC
Investigator, BC Children's Hospital
Neurologist, Pediatric Neurology, BC Children's Hospital
Neurology
Chen, J. and Ngo, A. and Rodriguez-Cruces, R. and Royer, J. and Caligiuri, M.E. and Gambardella, A. and Concha, L. and Keller, S.S. and Cendes, F. and Yasuda, C.L. and Alvim, M.K.M. and Bonilha, L. and Gleichgerrcht, E. and Focke, N.K. and Kreilkamp, B.A.K. and Domin, M. and Von Podewils, F. and Langner, S. and Rummel, C. and Wiest, R. and Martin, P. and Kotikalapudi, R. and Bender, B. and O?Brien, T.J. and Sinclair, B. and Vivash, L. and Kwan, P. and Desmond, P. and Lui, E. and Duma, G.M. and Bonanni, P. and Ballerini, A. and Vaudano, A.E. and Meletti, S. and Tondelli, M. and Alhusaini, S. and Doherty, C.P. and Cavalleri, G. and Delanty, N. and Kalviainen, R. and Jackson, G.D. and Kowalczyk, M. and Mascalchi, M. and Semmelroch, M.K.H.G. and Thomas, R.H. and Soltanian-Zadeh, H. and Davoodi-Bojd, E. and Zhang, J. and Lenge, M. and Guerrini, R. and Bartolini, E. and Hamandi, K. and Foley, S. and R{\"u}ber, T. and Bauer, T. and Weber, B. and Caldairou, B. and Depondt, C. and Absil, J. and Carr, S.J.A. and Abela, E. and Richardson, M.P. and Devinsky, O. and Pardoe, H.R. and Severino, M. and Striano, P. and Tortora, D. and Kaestner, E. and Hatton, S.N. and Arienzo, D. and Vos, S.B. and Ryten, M. and Taylor, P.N. and Duncan, J.S. and Whelan, C.D. and Galovic, M. and Winston, G.P. and Thomopoulos, S.I. and Thompson, P.M. and Sisodiya, S.M. and Labate, A. and McDonald, C. and Caciagli, L. and Bernasconi, N. and Bernasconi, A. and Lariviere, S. and Schrader, D.V. and Bernhardt, B.C.
DOI: 10.1212/WNL.0000000000213688Epilepsia
Niazi, F. and Mithani, K. and Suresh, H. and Wong, S.M. and Yau, I. and McRae, L. and Dinger, T.F. and Rutka, J.T. and Ochi, A. and Otsubo, H. and Weiss, S. and Sham, L. and Donner, E. and Chau, V. and Hadjinicolaou, A. and Major, P. and Weil, A.G. and Tailor, J. and Abel, T.J. and Remick, M. and Akwayena, E. and Schrader, D. and Bollo, R.J. and Smyth, M.D. and Aum, D. and Lew, S. and Wang, S. and Niazi, T. and Raskin, J.S. and Widjaja, E. and Weiner, H.L. and Gadgil, N. and LoPresti, M.A. and Albert, G.W. and Fallah, A. and Kerr, E. and Smith, M.L. and Jain, P. and Ibrahim, G.M.
DOI: 10.1111/epi.18520Biorxiv
Xie, K. and Sahlas, E. and Ngo, A. and Chen, J. and Arafat, T. and Royer, J. and Zhou, Y. and Rodr{\'i}guez-Cruces, R. and Dascal, A. and Caldairou, B. and Fadaie, F. and Barnett, A. and Audrain, S. and Larivi{\`e}re, S. and Caciagli, L. and Pana, R. and Weil, A.G. and Grova, C. and Frauscher, B. and Schrader, D.V. and Zhang, Z. and Concha, L. and Bernasconi, A. and Bernasconi, N. and Bernhardt, B.C.
DOI: 10.1101/2025.04.24.650457bioRxiv
Chen, J. and Ngo, A. and Rodrguez-Cruces, R. and Royer, J. and Caligiuri, M.E. and Gambardella, A. and Concha, L. and Keller, S.S. and Cendes, F. and Yasuda, C.L. and Alvim, M.K.M. and Bonilha, L. and Gleichgerrcht, E. and Focke, N.K. and Kreilkamp, B. and Domin, M. and von Podewils, F. and Langner, S. and Rummel, C. and Wiest, R. and Martin, P. and Kotikalapudi, R. and Bender, B. and O'Brien, T.J. and Sinclair, B. and Vivash, L. and Kwan, P. and Desmond, P.M. and Lui, E. and Duma, G.M. and Bonanni, P. and Ballerini, A. and Vaudano, A.E. and Meletti, S. and Tondelli, M. and Alhusaini, S. and Doherty, C.P. and Cavalleri, G.L. and Delanty, N. and Klviinen, R. and Jackson, G.D. and Kowalczyk, M. and Mascalchi, M. and Semmelroch, M. and Thomas, R.H. and Soltanian-Zadeh, H. and Davoodi-Bojd, E. and Zhang, J. and Lenge, M. and Guerrini, R. and Bartolini, E. and Hamandi, K. and Foley, S. and Rber, T. and Bauer, T. and Weber, B. and Caldairou, B. and Depondt, C. and Absil, J. and Carr, S.J.A. and Abela, E. and Richardson, M.P. and Devinsky, O. and Pardoe, H. and Severino, M. and Striano, P. and Tortora, D. and Kaestner, E. and Hatton, S.N. and Arienzo, D. and Vos, S.B. and Ryten, M. and Taylor, P.N. and Duncan, J.S. and Whelan, C.D. and Galovic, M. and Winston, G.P. and Thomopoulos, S.I. and Thompson, P.M. and Sisodiya, S.M. and Labate, A. and McDonald, C.R. and Caciagli, L. and Bernasconi, N. and Bernasconi, A. and Larivire, S. and Schrader, D. and Bernhardt, B.C.
DOI: 10.1101/2024.03.02.583073Pediatric Allergy and Immunology
Duke, S. and Maiarana, J. and Yousefi, P. and Burks, E. and Gerrie, S. and Setiadi, A. and Amid, A. and Boerkel, C. and Erdle, S. and Guttman, O. and Kanani, A. and Lawrence, S. and Lee, A.F. and Pourshahnazari, P. and Rayar, M. and Rozmus, J. and Schrader, D. and Sharma, M. and Shopsowitz, K.E. and Tan, R. and To, F. and Yang, C. and Hildebrand, K.J. and James, E. and Turvey, S.E. and Markle, J.G. and Biggs, C.M.
DOI: 10.1111/pai.14077Neurology
Ngo, A. and Royer, J. and Rodriguez-Cruces, R. and Xie, K. and Dekraker, J. and Auer, H. and Tavakol, S. and Lam, J. and Schrader, D.V. and Dudley, R.W.R. and Bernasconi, A. and Bernasconi, N. and Frauscher, B. and Lariviere, S. and Bernhardt, B.C.
DOI: 10.1212/WNL.0000000000209528Alexander Ngo and Jessica Royer and Ral Rodrguez-Cruces and Ke Xie and Jordan DeKraker and Hans Auer and Shahin Tavakol and Jack Lam and Dewi Schrader and Roy W. R. Dudley and Andrea Bernasconi and Neda Bernasconi and Birgit Frauscher and Sara Larivire and Boris C. Bernhardt
DOI: 10.1101/2023.08.22.55355208 / 2023
Brain
Lee, H.M. and Hong, S.-J. and Gill, R. and Caldairou, B. and Wang, I. and Zhang, J.-G. and Deleo, F. and Schrader, D. and Bartolomei, F. and Guye, M. and Cho, K.H. and Barba, C. and Sisodiya, S. and Jackson, G. and Hogan, R.E. and Wong-Kisiel, L. and Cascino, G.D. and Schulze-Bonhage, A. and Lopes-Cendes, I. and Cendes, F. and Guerrini, R. and Bernhardt, B. and Bernasconi, N. and Bernasconi, A.
DOI: 10.1093/brain/awad060Paediatrics and Child Health (Canada)
Lopez, A.A. and Patel, M. and Rayment, J.H. and Tam, H. and Roberts, A. and Laskin, S. and Ahmed, M.A. and Barakauskas, V. and Galanis, E. and Goldfarb, D. and Halparin, J. and Harris, K.C. and Kissoon, N. and Lawrence, S. and Mcguffin, D. and Meckler, G. and Noel, K. and Schrader, D. and Sherwood, M. and Singh, A. and Vercauteren, S. and Tucker, L. and Biggs, C.M.
DOI: 10.1093/pch/pxac018eBioMedicine
Miceli, F. and Millevert, C. and Soldovieri, M.V. and Mosca, I. and Ambrosino, P. and Carotenuto, L. and Schrader, D. and Lee, H.K. and Riviello, J. and Hong, W. and Risen, S. and Emrick, L. and Amin, H. and Ville, D. and Edery, P. and de Bellescize, J. and Michaud, V. and Van-Gils, J. and Goizet, C. and Willemsen, M.H. and Kleefstra, T. and M?ller, R.S. and Bayat, A. and Devinsky, O. and Sands, T. and Korenke, G.C. and Kluger, G. and Mefford, H.C. and Brilstra, E. and Lesca, G. and Milh, M. and Cooper, E.C. and Taglialatela, M. and Weckhuysen, S.
DOI: 10.1016/j.ebiom.2022.104130Paediatrics and Child Health (Canada)
Lopez, A.A. and Patel, M. and Rayment, J.H. and Tam, H. and Roberts, A. and Laskin, S. and Tucker, L. and Biggs, C.M. and Ahmed, M.A. and Barakauskas, V. and Galanis, E. and Goldfarb, D. and Halparin, J. and Harris, K.C. and Kissoon, N. and Lawrence, S. and McGuffin, D. and Meckler, G. and Noel, K. and Schrader, D. and Sherwood, M. and Singh, A. and Vercauteren, S.
DOI: 10.1093/pch/pxab110BMJ Open
Siegel, L. and Yan, H. and Warsi, N. and Wong, S. and Suresh, H. and Weil, A.G. and Ragheb, J. and Wang, S. and Rozzelle, C. and Albert, G.W. and Raskin, J. and Abel, T. and Hauptman, J. and Schrader, D.V. and Bollo, R. and Smyth, M.D. and Lew, S.M. and Lopresti, M. and Kizek, D.J. and Weiner, H.L. and Fallah, A. and Widjaja, E. and Ibrahim, G.M.
DOI: 10.1136/bmjopen-2021-055886Epilepsy and Behavior
Chiu, M. and Peinhof, S. and De Guzman, C. and Borhani, M. and Siu, C. and Kuzeljevic, B. and Schrader, D. and Huh, L. and Connolly, M.B.
DOI: 10.1016/j.yebeh.2021.107860Neurology
Gill, R.S. and Lee, H.-M. and Caldairou, B. and Hong, S.-J. and Barba, C. and Deleo, F. and D'Incerti, L. and Mendes Coelho, V.C. and Lenge, M. and Semmelroch, M. and Schrader, D.V. and Bartolomei, F. and Guye, M. and Schulze-Bonhage, A. and Urbach, H. and Cho, K.H. and Cendes, F. and Guerrini, R. and Jackson, G. and Hogan, R.E. and Bernasconi, N. and Bernasconi, A.
DOI: 10.1212/WNL.0000000000012698Epileptic Disorders
Larivire, S. and Federico, P. and Chinvarun, Y. and Jackson, G. and Morgan, V. and Rampp, S. and Vaudano, A.E. and Wang, I. and Cendes, F. and Boelman, C.G. and Bernasconi, A. and Bernasconi, N. and Bernhardt, B.C. and Schrader, D.V.
DOI: 10.1684/epd.2021.1312The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Lee J and Schrader D and Boelman C and Huh L and Connolly MB
DOI: 10.1017/cjn.2020.241 PubMed: 3314836411 / 2020
Epilepsia
Larivire, S. and Weng, Y. and Vos de Wael, R. and Royer, J. and Frauscher, B. and Wang, Z. and Bernasconi, A. and Bernasconi, N. and Schrader, D.V. and Zhang, Z. and Bernhardt, B.C.
DOI: 10.1111/epi.16540Cerebral Cortex
Larivire, S. and Vos De Wael, R. and Hong, S.-J. and Paquola, C. and Tavakol, S. and Lowe, A.J. and Schrader, D.V. and Bernhardt, B.C.
DOI: 10.1093/cercor/bhz069Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
M Chiu and S Peinhof and M Borhani and C DeGuzman and C Siu and B Kuzeljevic and D Schrader and L Huh and MB Connolly
DOI: 10.1017/cjn.2019.8006 / 2019
Human Brain Mapping
Lowe, A.J. and Paquola, C. and Vos de Wael, R. and Girn, M. and Lariviere, S. and Tavakol, S. and Caldairou, B. and Royer, J. and Schrader, D.V. and Bernasconi, A. and Bernasconi, N. and Spreng, R.N. and Bernhardt, B.C.
DOI: 10.1002/hbm.24767bioRxiv
Larivire, S. and Weng, Y. and de Wael, R.V. and Frauscher, B. and Wang, Z. and Bernasconi, A. and Bernasconi, N. and Schrader, D.V. and Zhang, Z. and Bernhardt, B.C.
DOI: 10.1101/756494Neuromethods
Schrader, D.S. and Bernasconi, N. and Bernasconi, A.
DOI: 10.1007/978-1-4939-7647-8_18Neurology
Hong, S.-J. and Bernhardt, B.C. and Caldairou, B. and Hall, J.A. and Guiot, M.C. and Schrader, D. and Bernasconi, N. and Bernasconi, A.
DOI: 10.1212/WNL.0000000000003632Neurology
Hong, S.-J. and Bernhardt, B.C. and Schrader, D.S. and Bernasconi, N. and Bernasconi, A.
DOI: 10.1212/WNL.0000000000002374Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Hong, S.-J. and Bernhardt, B.C. and Schrader, D. and Caldairou, B. and Bernasconi, N. and Bernasconi, A.
DOI: 10.1007/978-3-319-24571-3_60Neurology
Hong, S.-J. and Kim, H. and Schrader, D. and Bernasconi, N. and Bernhardt, B.C. and Bernasconi, A.
DOI: 10.1212/WNL.0000000000000543American Journal of Neuroradiology
Frlich, A.M.J. and Schrader, D. and Klotz, E. and Schramm, R. and Wasser, K. and Knauth, M. and Schramm, P.
DOI: 10.3174/ajnr.A3533Nature Reviews Neurology
Bernasconi, A. and Bernasconi, N. and Bernhardt, B.C. and Schrader, D.
DOI: 10.1038/nrneurol.2010.199European Journal of Paediatric Neurology
Schrader, D. and Shukla, R. and Gatrill, R. and Farrell, K. and Connolly, M.
DOI: 10.1016/j.ejpn.2010.08.005Journal of Clinical Neurophysiology
Schrader, D. and Langill, L. and Singhal, A. and Steinbok, P. and Connolly, M.B.
DOI: 10.1097/WNP.0b013e3181baaacfEuropean Journal of Paediatric Neurology
Schrader, D.V. and Steinbok, P. and Connolly, M.
DOI: 10.1016/j.ejpn.2008.01.011Neurocritical Care
Ng, Y.-T. and Bristol, R.E. and Schrader, D.V. and Smith, K.A.
DOI: 10.1007/s12028-007-0038-4Neuroscience
Chechneva, O. and Dinkel, K. and Schrader, D. and Reymann, K.G.
DOI: 10.1016/j.neuroscience.2005.07.058Background
Surgery is the most effective treatment for drug-resistant childhood epilepsy. Yet, ~30 per cent of patients show post-surgical seizure recurrence and many suffer from cognitive side effects. So far, an outcome cannot be reliably predicted for a given patient prior to intervention.
Objectives
1) Integrate preoperative MRI markers and data on the actual surgery for more effective prediction;
2) analyze brain change from pre- to postoperative time points, mapping alterations of non-resected areas; 3) simulate network reorganization using connectome models.
Hypothesis. Combining preoperative markers of patient anatomy with with models that simulate consequences of surgery will yield high accuracy in predicting clinical and cognitive outcomes.
Methods
In children that will undergo epilepsy surgery, we will obtain MRI and neurocognitive data shortly before surgery, 6 months after surgery (and 12 months after surgery. We will overlay resection extent (from postoperative MRI) with preoperative MRI features (atrophy, gliosis, myelin), testing whether anomalies outside the resection margin predict seizure relapse. In addition, fMRI pattern analysis will localize regions critical for language/memory function, testing whether their resection relates to postoperative cognitive decline. Mixed-effects models will map MRI feature change, assessing surgical consequences. Connectome-based models will be devised to predict downstream degeneration and functional reorganization after surgery in non-resected areas. Supervised learners will predict outcomes based on preoperative data and simulations.
Expected Results
Empirical studies on surgical consequences will help build effective in silico models that optimize outcome prediction, improving clinical decision-making in >10,000 children with drug-resistant seizures in Canada.
Improved detection of Focal Cortical Dysplasia.
Focal cortical dysplasia (FCD) is the most common cause of surgically-treatable, extra-temporal epilepsy. Unfortunately, the findings of FCD on MRI are often subtle and can be easily overlooked. We are using advanced MRI techniques to improve the detection of focal cortical dysplasia, allowing us to offer the life changing benefits of epilepsy surgery to more patients.
SickKids Foundation - New Investigator Grant 2016 "Connectome informed simulations of pediatric epilepsy surgery"
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