- Overview
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My research interests lie at the interface between health sciences, bioinformatics, and clinical informatics, focusing on methodologies to integrate heterogeneous datasets and facilitate re-use of existing data while ensuring data privacy and security. I believe Clinical Research Informatics is essential to well designed and maintained clinical study. Standardization and harmonization are key to good quality and reusable data collections, which are necessary for the translation of research into improved clinical practices.
All the tools I have participated in developing (Neurocarta, PAZAR,...) are open to the scientific community and the articles describing them published in open-access journals. It is important to me that research results are made available to all as fast as possible.
- Publications
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TrustSphere - Enabling patient-directed access to clinical and patient-generated health data: a novel multi-source architecture (Preprint)
Tibor van Rooij and Taqdir Ali and J. Quetzalcóatl Toledo-Marín and Alec Laws and Bonnie Barrett and Beth A Payne and Shazhan Amed and Elodie Portales-Casamar and Wyeth W Wasserman and Matthias Görges
DOI: 10.2196/preprints.70061
12/2024An Individualized Postoperative Pain Risk Communication Tool for Use in Pediatric Surgery: Co-Design and Usability Evaluation (Preprint)
Michael D Wood and Nicholas C West and Christina Fokkens and Ying Chen and Kent C Loftsgard and Krystal Cardinal and Simon D Whyte and Elodie Portales-Casamar and Matthias Görges
DOI: 10.2196/preprints.46785
02/2023Neonatal and Early Childhood Outcomes of Twin and Singleton Infants Born Preterm
Journal of Pediatrics
DOI: 10.1016/j.jpeds.2023.02.021
2023Deploying an ethics needs assessment to inform a navigational tool for research compliance pathways at a provincial Canadian health authority
Accountability in Research
DOI: 10.1080/08989621.2023.2233419
2023Impact of Perinatal Exposure to SARS-CoV-2 Infection on Early Health Outcomes among Infants Born from 2020 to 2021 in British Columbia, Canada
Canadian Journal of Infectious Diseases and Medical Microbiology
DOI: 10.1155/2023/9968774
2023An Individualized Postoperative Pain Risk Communication Tool for Use in Pediatric Surgery: Co-Design and Usability Evaluation
JMIR Pediatrics and Parenting
DOI: 10.2196/46785
2023The application of epiphenotyping approaches to DNA methylation array studies of the human placenta
Epigenetics and Chromatin
DOI: 10.1186/s13072-023-00507-5
2023Identifying Risk Factors, Patient-Reported Experience and Outcome Measures, and Data Capture Tools for an Individualized Pain Prediction Tool in Pediatrics: Focus Group Study
JMIR Perioperative Medicine
Michael D Wood and Nicholas C West and Rama S Sreepada and Kent C Loftsgard and Luba Petersen and Julie M Robillard and Patricia Page and Randa Ridgway and Neil K Chadha and Elodie Portales-Casamar and Matthias Görges
DOI: 10.2196/42341
11/2022Identification of Requirements for a Postoperative Pediatric Pain Risk Communication Tool: Focus Group Study With Clinicians and Family Members
JMIR Pediatrics and Parenting
Michael D Wood and Kim Correa and Peijia Ding and Rama Sreepada and Kent C Loftsgard and Isabel Jordan and Nicholas C West and Simon D Whyte and Elodie Portales-Casamar and Matthias Görges
DOI: 10.2196/37353
07/2022Profiling placental DNA methylation associated with maternal SSRI treatment during pregnancy
Amy M. Inkster and Chaini Konwar and Maria S. Peñaherrera and Ursula Brain and Almas Khan and E. Magda Price and Johanna M. Schuetz and Élodie Portales-Casamar and Amber Burt and Carmen J. Marsit and Cathy Vaillancourt and Tim F. Oberlander and Wendy P. Robinson
DOI: 10.1101/2022.06.21.22276723
06/2022Toward Building a Provincial Diabetes Registry of Children and Youth Living With Diabetes in British Columbia, Canada
Canadian Journal of Diabetes
Aysha Ayub and Crystal Ng and Elodie Portales-Casamar and Daniel Metzger and Shazhan Amed
DOI: 10.1016/j.jcjd.2021.11.006
06/2022Identification of Requirements for a Postoperative Pediatric Pain Risk Communication Tool: Focus Group Study With Clinicians and Family Members (Preprint)
Michael D Wood and Kim Correa and Peijia Ding and Rama Sreepada and Kent C Loftsgard and Isabel Jordan and Nicholas C West and Simon D Whyte and Elodie Portales-Casamar and Matthias Görges
DOI: 10.2196/preprints.37353
02/2022Applications of Aspect-based Sentiment Analysis on Psychiatric Clinical Notes to Study Suicide in Youth.
AMIA ... Annual Symposium proceedings. AMIA Symposium
PubMed: 34457137
05/2021Association of timing of birth with mortality among preterm infants born in Canada
Journal of Perinatology
Rizzolo, A. and Shah, P.S. and Bertelle, V. and Makary, H. and Ye, X.Y. and Abenhaim, H.A. and Piedboeuf, B. and Beltempo, M. and Abenhaim, H. and Afifi, J. and Alvaro, R. and Andrews, J. and Armson, A. and Audibert, F. and Aziz, K. and Ballantyne, M. and Barrett, J. and Beltempo, M. and Berard, A. and Bertelle, V. and Blais, L. and Bocking, A. and Bodani, J. and Burrows, J. and Butt, K. and Canning, R. and Carson, G. and Chaillet, N. and Chandra, S. and Church, P. and Cieslak, Z. and Coughlin, K. and Crane, J. and Creighton, D. and Da Silva, O. and Daboval, T. and Dahlgren, L. and Daspal, S. and de Cabo, C. and Deshpandey, A. and Dow, K. and Drolet, C. and Dunn, M. and el Helou, S. and El-Chaar, D. and El-Naggar, W. and Fajardo, C. and Foster, J. and Gagnon, R. and Gratton, R. and Han, V. and Harrison, A. and Hasan, S. and Helewa, M. and Hicks, M. and Joseph, K.S. and Kajetanowicz, A. and Kalapesi, Z. and Khairy, M. and Lacaze-Masmonteil, T. and Lee, K.-S. and Lemyre, B. and Lodha, A. and Louis, D. and Luu, T.M. and Ly, L. and Majnemer, A. and Makary, H. and Marc, I. and Masse, E. and McDonald, S.D. and McMillan, D. and Melamed, N. and Metcalfe, A. and Moddemann, D. and Monterrosa, L. and Morais, M. and Mukerji, A. and Mundle, W. and Murphy, L. and Murphy, K. and Nuyt, A.-M. and Nwaesei, C. and O?Brien, K. and Offringa, M. and Ojah, C. and Ouellet, A. and Pasquier, J.-C. and Pechlivanoglou, P. and Pelausa, E. and Piedboeuf, B. and Portales-Casamar, E. and Premji, S. and Puligandla, P. and Pullenayegum, E. and Reichert, A. and Robson, K. and Schneider, C. and Seshia, M. and Shah, P.S. and Shah, V. and Sherlock, R. and Shivananda, S. and Singhal, N. and Skarsgard, E. and Skoll, A. and Smith, G. and Synnes, A. and Thériault, K. and Ting, J. and Tough, S. and Toye, J. and Ubhi, J. and Vincer, M. and Whittle, W. and Whyte, H. and Wilson, D. and Wood, S. and Ye, P. and Yee, W. and Zwicker, J.
DOI: 10.1038/s41372-021-01092-9
2021An interrupted time-series analysis of pediatric emergency department visits during the coronavirus disease 2019 pandemic
Pediatric Emergency Care
Irvine, M.A. and Portales-Casamar, E. and Goldman, R.D.
DOI: 10.1097/PEC.0000000000002404
2021Rates and Determinants of Mother's Own Milk Feeding in Infants Born Very Preterm
Journal of Pediatrics
Dharel, D. and Singhal, N. and Wood, C. and Cieslak, Z. and Bacchini, F. and Shah, P.S. and Ye, X.Y. and Alshaikh, B. and Abenhaim, H. and Afifi, J. and Alvaro, R. and Andrews, J. and Armson, A. and Audibert, F. and Aziz, K. and Ballantyne, M. and Barrett, J. and Beltempo, M. and Berard, A. and Bertelle, V. and Blais, L. and Bocking, A. and Bodani, J. and Burrows, J. and Butt, K. and Canning, R. and Carson, G. and Chaillet, N. and Chandra, S. and Church, P. and Coughlin, K. and Crane, J. and Creighton, D. and Da Silva, O. and Daboval, T. and Dahlgren, L. and Daspal, S. and de Cabo, C. and Deshpandey, A. and Dow, K. and Drolet, C. and Dunn, M. and el Helou, S. and El-Chaar, D. and El-Naggar, W. and Fajardo, C. and Foster, J. and Gagnon, R. and Gratton, R. and Han, V. and Harrison, A. and Hasan, S. and Helewa, M. and Hicks, M. and Joseph, K.S. and Kajetanowicz, A. and Kalapesi, Z. and Khairy, M. and Lacaze-Masmonteil, T. and Lee, K.-S. and Lemyre, B. and Lodha, A. and Louis, D. and Mai Luu, T. and Ly, L. and Majnemer, A. and Makary, H. and Marc, I. and Masse, E. and McDonald, S.D. and McMillan, D. and Melamed, N. and Metcalfe, A. and Moddemann, D. and Monterrosa, L. and Morais, M. and Mukerji, A. and Mundle, W. and Murphy, L. and Murphy, K. and Nuyt, A.-M. and Nwaesei, C. and O'Brien, K. and Offringa, M. and Ojah, C. and Ouellet, A. and Pasquier, J.-C. and Pechlivanoglou, P. and Pelausa, E. and Piedboeuf, B. and Portales-Casamar, E. and Premji, S. and Puligandla, P. and Pullenayegum, E. and Reichert, A. and Schneider, C. and Seshia, M. and Shah, V. and Sherlock, R. and Shivananda, S. and Skarsgard, E. and Skoll, A. and Smith, G. and Synnes, A. and Thériault, K. and Ting, J. and Tough, S. and Toye, J. and Ubhi, J. and Vincer, M. and Whittle, W. and Whyte, H. and Wilson, D. and Wood, S. and Ye, P. and Yee, W. and Zwicker, J.
DOI: 10.1016/j.jpeds.2021.04.037
2021Costs of Neonatal Intensive Care for Canadian Infants with Preterm Birth
Journal of Pediatrics
Rios, J.D. and Shah, P.S. and Beltempo, M. and Louis, D. and Mukerji, A. and Premji, S. and Shah, V. and Lee, S.K. and Pechlivanoglou, P. and Abenhaim, H. and Afifi, J. and Alvaro, R. and Andrews, J. and Armson, A. and Audibert, F. and Aziz, K. and Ballantyne, M. and Barrett, J. and Berard, A. and Bertelle, V. and Blais, L. and Bocking, A. and Bodani, J. and Burrows, J. and Butt, K. and Canning, R. and Carson, G. and Chaillet, N. and Chandra, S. and Church, P. and Cieslak, Z. and Crane, J. and Creighton, D. and Da Silva, O. and Daboval, T. and Dahlgren, L. and Daspal, S. and de Cabo, C. and Deshpandey, A. and Dow, K. and Drolet, C. and Dunn, M. and Salhab el Helou and El-Chaar, D. and El-Naggar, W. and Fajardo, C. and Gagnon, R. and Gratton, R. and Han, V. and Harrison, A. and Hasan, S. and Helewa, M. and Hicks, M. and Joseph, K.S. and Kajetanowicz, A. and Kalapesi, Z. and Khairy, M. and Lacaze-Masmonteil, T. and Lee, K.-S. and Lemyre, B. and Lodha, A. and Mai Luu, T. and Ly, L. and Majnemer, A. and Makary, H. and Marc, I. and Masse, E. and McDonald, S.D. and McMillan, D. and Melamed, N. and Metcalfe, A. and Moddemann, D. and Monterrosa, L. and Morais, M. and Mundle, W. and Murphy, L. and Murphy, K. and Nuyt, A.-M. and Nwaesei, C. and O'Brien, K. and Offringa, M. and Ojah, C. and Ouellet, A. and Pasquier, J.-C. and Pelausa, E. and Piedboeuf, B. and Portales-Casamar, E. and Puligandla, P. and Pullenayegum, E. and Reichert, A. and Robson, K. and Schneider, C. and Seshia, M. and Sherlock, R. and Shivananda, S. and Singhal, N. and Skarsgard, E. and Skoll, A. and Smith, G. and Synnes, A. and Thériault, K. and Ting, J. and Tough, S. and Toye, J. and Ubhi, J. and Vincer, M. and Whittle, W. and Whyte, H. and Wilson, D. and Wood, S. and Ye, P. and Yee, W. and Zwicker, J. and Jaideep Kanungo and Mehrem, A.A. and Sankaran, K. and Adie, M. and Khurshid, F. and Barrington, K. and Lapoint, A. and Ethier, G. and Claveau, M. and Emberley, J.
DOI: 10.1016/j.jpeds.2020.09.045
2021Applications of Aspect-based Sentiment Analysis on Psychiatric Clinical Notes to Study Suicide in Youth
AMIA ... Annual Symposium proceedings. AMIA Symposium
George, A. and Johnson, D. and Carenini, G. and Eslami, A. and Ng, R. and Portales-Casamar, E.
2021Mode of delivery and neonatal outcomes in extremely preterm Vertex/nonVertex twins
American Journal of Obstetrics and Gynecology
Hiersch, L. and Shah, P.S. and Khurshid, F. and Masse, E. and Murphy, K. and McDonald, S.D. and Carson, G. and Barrett, J. and Melamed, N. and Ting, J. and Cieslak, Z. and Sherlock, R. and Abou Mehrem, A. and Toye, J. and Fajardo, C. and Kalapesi, Z. and Bodani, J. and Sankaran, K. and Daspal, S. and Seshia, M. and Louis, D. and Alvaro, R. and Mukerji, A. and Da Silva, O. and Adie, M. and Lee, K.-S. and Dunn, M. and Lemyre, B. and Pelausa, E. and Barrington, K. and Lapoint, A. and Ethier, G. and Drolet, C. and Piedboeuf, B. and Claveau, M. and Beltempo, M. and Bertelle, V. and Canning, R. and Makary, H. and Ojah, C. and Monterrosa, L. and Emberley, J. and Afifi, J. and Kajetanowicz, A. and Lee, S.K. and Abenhaim, H. and Andrews, J. and Armson, A. and Audibert, F. and Aziz, K. and Ballantyne, M. and Berard, A. and Blais, L. and Bocking, A. and Burrows, J. and Butt, K. and Chaillet, N. and Chandra, S. and Church, P. and Coughlin, K. and Crane, J. and Creighton, D. and Daboval, T. and Dahlgren, L. and de Cabo, C. and Deshpandey, A. and Dow, K. and el Helou, S. and El-Chaar, D. and El-Naggar, W. and Foster, J. and Gagnon, R. and Gratton, R. and Han, V. and Harrison, A. and Hasan, S. and Helewa, M. and Hicks, M. and Joseph, K.S. and Lacaze-Masmonteil, T. and Lodha, A. and Luu, T.M. and Ly, L. and Majnemer, A. and Marc, I. and McMillan, D. and Metcalfe, A. and Moddemann, D. and Morais, M. and Mundle, W. and Murphy, L. and Nuyt, A.-M. and Nwaesei, C. and O'Brien, K. and Offringa, M. and Ouellet, A. and Pasquier, J.-C. and Pechlivanoglou, P. and Portales-Casamar, E. and Premji, S. and Puligandla, P. and Pullenayegum, E. and Reichert, A. and Robson, K. and Schneider, C. and Shah, V. and Shivananda, S. and Singhal, N. and Skarsgard, E. and Skoll, A. and Smith, G. and Synnes, A. and Thériault, K. and Tough, S. and Ubhi, J. and Vincer, M. and Whittle, W. and Whyte, H. and Wilson, D. and Wood, S. and Ye, P. and Yee, W. and Zwicker, J.
DOI: 10.1016/j.ajog.2020.12.002
2021Benefit of antenatal corticosteroids by year of birth among preterm infants in Canada during 2003–2017: a population-based cohort study
BJOG: An International Journal of Obstetrics and Gynaecology
Melamed, N. and Murphy, K. and Barrett, J. and Asztalos, E. and McDonald, S.D. and Yoon, E.W. and Shah, P.S. and Kanungo, J. and Ting, J. and Cieslak, Z. and Sherlock, R. and Mehrem, A.A. and Toye, J. and Fajardo, C. and Kalapesi, Z. and Bodani, J. and Sankaran, K. and Daspal, S. and Seshia, M. and Louis, D. and Alvaro, R. and Mukerji, A. and Da Silva, O. and Adie, M. and Lee, K.-S. and Dunn, M. and Lemyre, B. and Khurshid, F. and Pelausa, E. and Barrington, K. and Lapoint, A. and Ethier, G. and Drolet, C. and Piedboeuf, B. and Claveau, M. and Beltempo, M. and Bertelle, V. and Masse, E. and Canning, R. and Makary, H. and Ojah, C. and Monterrosa, L. and Emberley, J. and Afifi, J. and Kajetanowicz, A. and Lee, S.K. and Abenhaim, H. and Andrews, J. and Armson, A. and Audibert, F. and Aziz, K. and Ballantyne, M. and Berard, A. and Blais, L. and Bocking, A. and Burrows, J. and Butt, K. and Carson, G. and Chaillet, N. and Chandra, S. and Church, P. and Coughlin, K. and Crane, J. and Creighton, D. and Daboval, T. and Dahlgren, L. and de Cabo, C. and Deshpandey, A. and Dow, K. and el Helou, S. and El-Chaar, D. and El-Naggar, W. and Foster, J. and Gagnon, R. and Gratton, R. and Han, V. and Harrison, A. and Hasan, S. and Helewa, M. and Hicks, M. and Joseph, K.S. and Khairy, M. and Lacaze-Masmonteil, T. and Lodha, A. and Luu, M. and Ly, L. and Majnemer, A. and Marc, I. and McMillan, D. and Metcalfe, A. and Moddemann, D. and Morais, M. and Mundle, W. and Murphy, L. and Nuyt, A.-M. and Nwaesei, C. and O'Brien, K. and Offringa, M. and Ouellet, A. and Pasquier, J.-C. and Pechlivanoglou, P. and Portales-Casamar, E. and Premji, S. and Puligandla, P. and Pullenayegum, E. and Reichert, A. and Robson, K. and Schneider, C. and Shah, V. and Shivananda, S. and Singhal, N. and Skarsgard, E. and Skoll, A. and Smith, G. and Synnes, A. and Thériault, K. and Tough, S. and Ubhi, J. and Vincer, M. and Whittle, W. and Whyte, H. and Wilson, D. and Wood, S. and Ye, P. and Yee, W. and Zwicker, J.
DOI: 10.1111/1471-0528.16511
2021Paediatric patients seen in 18 emergency departments during the COVID-19 pandemic.
Emergency medicine journal : EMJ
Goldman RD and Grafstein E and Barclay N and Irvine MA and Portales-Casamar E
DOI: 10.1136/emermed-2020-210273
PubMed: 33127743
10/2020What You Need to Know Before Implementing a Clinical Research Data Warehouse: Comparative Review of Integrated Data Repositories in Health Care Institutions.
JMIR formative research
Gagalova KK and Leon Elizalde MA and Portales-Casamar E and Görges M
DOI: 10.2196/17687
PubMed: 32852280
08/2020What You Need to Know Before Implementing a Clinical Research Data Warehouse: Comparative Review of Integrated Data Repositories in Health Care Institutions (Preprint)
Kristina K Gagalova and M Angelica Leon Elizalde and Elodie Portales-Casamar and Matthias Görges
DOI: 10.2196/preprints.17687
01/2020Poor Correlation of Oral Swabs with Esophageal Eosinophil Counts
Dysphagia
Avinashi, V. and Chan, J.M. and Bush, J.W. and Vallance, B.A. and Yang, H. and Portales-Casamar, E. and Soller, L. and Mill, C. and Chan, E.S.
DOI: 10.1007/s00455-019-10082-1
2020Data access and usage practices across a cohort of researchers at a large tertiary pediatric hospital: Qualitative survey study
Journal of Medical Internet Research
Ho, H.K.K. and Görges, M. and Portales-Casamar, E.
DOI: 10.2196/medinform.8724
2018Pediatric eosinophilic esophagitis is associated with increased lamina propria immunoglobulin g4-positive plasma cells
Journal of Pediatric Gastroenterology and Nutrition
Mohammad, N. and Avinashi, V. and Chan, E. and Vallance, B.A. and Portales-Casamar, E. and Bush, J.W.
DOI: 10.1097/MPG.0000000000001949
2018Unpacking the Heterogeneity of Cognitive Functioning in Children and Adolescents with Fetal Alcohol Spectrum Disorder: Determining the Role of Moderators and Strengths
Advances in Neurodevelopmental Disorders
Kaitlyn McLachlan and Angelina Paolozza and Katrina Kully-Martens and Elodie Portales-Casamar and Paul Pavlidis and Gail Andrew and Ana Hanlon-Dearman and Christine Loock and Audrey McFarlane and Sarah M. Nikkel and Jacqueline Pei and Tim F. Oberlander and Dawa Samdup and James N. Reynolds and Carmen Rasmussen
DOI: 10.1007/s41252-017-0034-4
09/2017An environmental scan of data access and usage practices across a cohort of researchers at a large tertiary paediatric hospital
Hoi Ki Kiki Ho and Matthias G¿rges and Elodie Portales-Casamar
DOI: 10.2196/preprints.8724.a
08/2017Data Access and Usage Practices Across a Cohort of Researchers at a Large Tertiary Pediatric Hospital: Qualitative Survey Study (Preprint)
Hoi Ki Kiki Ho and Matthias G¿rges and Elodie Portales-Casamar
DOI: 10.2196/preprints.8724
08/2017Many Children Referred to a Tertiary Care Pediatric Allergy Clinic Do Not Have an Allergy
Journal of Allergy and Clinical Immunology
Victoria E. Cook and Jordan Yeo and Christopher Mill and Kyla Hildebrand and Elodie Portales-Casamar and Edmond S. Chan
DOI: 10.1016/j.jaci.2016.12.134
02/2017Profiling placental and fetal DNA methylation in human neural tube defects
Epigenetics and Chromatin
Price, E.M. and Peñaherrera, M.S. and Portales-Casamar, E. and Pavlidis, P. and Van Allen, M.I. and McFadden, D.E. and Robinson, W.P.
DOI: 10.1186/s13072-016-0054-8
2016Interactive Exploration, Analysis, and Visualization of Complex Phenome–Genome Datasets with ASPIREdb
Human Mutation
Tan, P.P.C. and Rogic, S. and Zoubarev, A. and McDonald, C. and Lui, F. and Charathsandran, G. and Jacobson, M. and Belmadani, M. and Leong, J. and Van Rossum, T. and Portales-Casamar, E. and Qiao, Y. and Calli, K. and Liu, X. and Hudson, M. and Rajcan-Separovic, E. and Lewis, M.E.S. and Pavlidis, P.
DOI: 10.1002/humu.23011
2016RAAV-compatible MiniPromoters for restricted expression in the brain and eye
Molecular Brain
De Leeuw, C.N. and Korecki, A.J. and Berry, G.E. and Hickmott, J.W. and Lam, S.L. and Lengyell, T.C. and Bonaguro, R.J. and Borretta, L.J. and Chopra, V. and Chou, A.Y. and D'Souza, C.A. and Kaspieva, O. and Laprise, S. and McInerny, S.C. and Portales-Casamar, E. and Swanson-Newman, M.I. and Wong, K. and Yang, G.S. and Zhou, M. and Jones, S.J.M. and Holt, R.A. and Asokan, A. and Goldowitz, D. and Wasserman, W.W. and Simpson, E.M.
DOI: 10.1186/s13041-016-0232-4
2016DNA methylation signature of human fetal alcohol spectrum disorder
Epigenetics and Chromatin
Portales-Casamar, E. and Lussier, A.A. and Jones, M.J. and MacIsaac, J.L. and Edgar, R.D. and Mah, S.M. and Barhdadi, A. and Provost, S. and Lemieux-Perreault, L.-P. and Cynader, M.S. and Chudley, A.E. and Dubé, M.-P. and Reynolds, J.N. and Pavlidis, P. and Kobor, M.S.
DOI: 10.1186/s13072-016-0074-4
2016Communication error analysis of sleep/wake-behaviour assessments: The need for optimizing communication and data gathering with new technologies
Sleep Medicine
G. McAllister and D. Elbe and N. De Pietro and E. Portales-casamar and D. Lin and T. Rosenfeld and D. Penn and S. Stockler and D. Mount and O. Ipsiroglu
DOI: 10.1016/j.sleep.2015.02.1492
2015Sharing with more caring: Coordinating and improving the ethical governance of data and biomaterials obtained from children
PLoS ONE
Longstaff, H. and Khramova, V. and Portales-Casamar, E. and Illes, J.
DOI: 10.1371/journal.pone.0130527
2015LORIS: Enhanced tools for data management in neurodevelopmental studies
International Journal of Developmental Neuroscience
C. Rogers and P. Kostopoulos and D. McFarlane and Z. Mohades and D. Brien and N. St-Georges and E. Portales-Casamar and S. Das and A. Evans
DOI: 10.1016/j.ijdevneu.2015.04.334
2015DNA methylation changes in fetal alcohol spectrum disorder
International Journal of Developmental Neuroscience
Elodie Portales-Casamar and Sarah M. Mah and Julie L. MacIsaac and Amina Barhdadi and Sylvie Provost and Marie-Pierre Dubé and James N. Reynolds and Paul Pavlidis and Michael S. Kobor
DOI: 10.1016/j.ijdevneu.2015.04.336
2015A SNP in the HTT promoter alters NF-¿B binding and is a bidirectional genetic modifier of Huntington disease
Nature Neuroscience
Becanovic, K. and N?rrem?lle, A. and Neal, S.J. and Kay, C. and Collins, J.A. and Arenillas, D. and Lilja, T. and Gaudenzi, G. and Manoharan, S. and Doty, C.N. and Beck, J. and Lahiri, N. and Portales-Casamar, E. and Warby, S.C. and Connolly, C. and De Souza, R.A.G. and Tabrizi, S.J. and Hermanson, O. and Langbehn, D.R. and Hayden, M.R. and Wasserman, W.W. and Leavitt, B.R.
DOI: 10.1038/nn.4014
2015Neurocarta: online platform for integration and sharing of phenotypic and genomics information
Frontiers in Neuroinformatics
Portales-Casamar Elodie and Ch’ng Carolyn and Lui Frances and St-Georges Nicolas and Zoubarev Anton and Pavlidis Paul
DOI: 10.3389/conf.fninf.2014.08.00025
2014Targeted CNS delivery using human MiniPromoters and demonstrated compatibility with adeno-associated viral vectors
Molecular Therapy - Methods and Clinical Development
de Leeuw, C.N. and Dyka, F.M. and Boye, S.L. and Laprise, S. and Zhou, M. and Chou, A.Y. and Borretta, L. and McInerny, S.C. and Banks, K.G. and Portales-Casamar, E. and Swanson, M.I. and D'Souza, C.A. and Boye, S.E. and Jones, S.J. and Holt, R.A. and Goldowitz, D. and Hauswirth, W.W. and Wasserman, W.W. and Simpson, E.M.
DOI: 10.1038/mtm.2013.5
2014Meta-analysis of human methylomes reveals stably methylated sequences surrounding CpG islands associated with high gene expression
Epigenetics and Chromatin
Edgar, R. and Tan, P.P.C. and Portales-Casamar, E. and Pavlidis, P.
DOI: 10.1186/1756-8935-7-28
2014Neurocarta: Aggregating and sharing disease-gene relations for the neurosciences
BMC Genomics
Portales-Casamar, E. and Ch'ng, C. and Lui, F. and St-Georges, N. and Zoubarev, A. and Lai, A.Y. and Lee, M. and Kwok, C. and Kwok, W. and Tseng, L. and Pavlidis, P.
DOI: 10.1186/1471-2164-14-129
2013Non-coding-regulatory regions of human brain genes delineated by bacterial artificial chromosome knock-in mice
BMC Biology
Schmouth, J.-F. and Castellarin, M. and Laprise, S. and Banks, K.G. and Bonaguro, R.J. and McInerny, S.C. and Borretta, L. and Amirabbasi, M. and Korecki, A.J. and Portales-Casamar, E. and Wilson, G. and Dreolini, L. and Jones, S.J.M. and Wasserman, W.W. and Goldowitz, D. and Holt, R.A. and Simpson, E.M.
DOI: 10.1186/1741-7007-11-106
2013The transcription factor encyclopedia.
Yusuf D and Butland SL and Swanson MI and Bolotin E and Ticoll A and Cheung WA and Zhang XY and Dickman CT and Fulton DL and Lim JS and Schnabl JM and Ramos OH and Vasseur-Cognet M and de Leeuw CN and Simpson EM and Ryffel GU and Lam EW and Kist R and Wilson MS and Marco-Ferreres R
DOI: 10.1186/gb-2012-13-3-r24
PubMed: 22458515
2012MIR@NT@N: A framework integrating transcription factors, microRNAs and their targets to identify sub-network motifs in a meta-regulation network model
BMC Bioinformatics
Le Béchec, A. and Portales-Casamar, E. and Vetter, G. and Moes, M. and Zindy, P. and Saumet, A. and Arenillas, D. and Theillet, C. and Wasserman, W.W. and Lecellier, C.-H. and Friederich, E.
DOI: 10.1186/1471-2105-12-67
2011The NeuroDevNet Neuroinformatics Core
Seminars in Pediatric Neurology
Portales-Casamar, E. and Evans, A. and Wasserman, W. and Pavlidis, P.
DOI: 10.1016/j.spen.2011.02.001
2011Laboratory Animal Management Assistant (LAMA): A LIMS for active research colonies
Mammalian Genome
Milisavljevic, M. and Hearty, T. and Wong, T.Y.T. and Portales-Casamar, E. and Simpson, E.M. and Wasserman, W.W.
DOI: 10.1007/s00335-010-9258-6
2010Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through chip-seq profiling and network analysis
Nucleic Acids Research
Malhotra, D. and Portales-Casamar, E. and Singh, A. and Srivastava, S. and Arenillas, D. and Happel, C. and Shyr, C. and Wakabayashi, N. and Kensler, T.W. and Wasserman, W.W. and Biswal, S.
DOI: 10.1093/nar/gkq212
2010A regulatory toolbox of MiniPromoters to drive selective expression in the brain
Proceedings of the National Academy of Sciences of the United States of America
Portales-Casamar, E. and Swanson, D.J. and Liu, L. and De Leeuw, C.N. and Banks, K.G. and Ho Sui, S.J. and Fulton, D.L. and Ali, J. and Amirabbasi, M. and Arenillas, D.J. and Babyak, N. and Black, S.F. and Bonaguro, R.J. and Brauer, E. and Candido, T.R. and Castellarin, M. and Chen, J. and Chen, Y. and Cheng, J.C.Y. and Chopra, V. and Docking, T.R. and Dreolini, L. and D'Souza, C.A. and Flynn, E.K. and Glenn, R. and Hatakka, K. and Hearty, T.G. and Imanian, B. and Jiang, S. and Khorasan-zadeh, S. and Komljenovic, I. and Laprise, S. and Liao, N.Y. and Lim, J.S. and Lithwick, S. and Liu, F. and Liu, J. and Lu, M. and McConechy, M. and McLeod, A.J. and Milisavljevic, M. and Mis, J. and O'Connor, K. and Palma, B. and Palmquist, D.L. and Schmouth, J.-F. and Swanson, M.I. and Tam, B. and Ticoll, A. and Turner, J.L. and Varhol, R. and Vermeulen, J. and Watkins, R.F. and Wilson, G. and Wong, B.K.Y. and Wong, S.H. and Wong, T.Y.T. and Yang, G.S. and Ypsilanti, A.R. and Jones, S.J.M. and Holt, R.A. and Goldowitz, D. and Wasserman, W.W. and Simpson, E.M.
DOI: 10.1073/pnas.1009158107
2010JASPAR 2010: The greatly expanded open-access database of transcription factor binding profiles
Nucleic Acids Research
Portales-Casamar, E. and Thongjuea, S. and Kwon, A.T. and Arenillas, D. and Zhao, X. and Valen, E. and Yusuf, D. and Lenhard, B. and Wasserman, W.W. and Sandelin, A.
DOI: 10.1093/nar/gkp950
2009Transcriptional repression of microRNA genes by PML-RARA increases expression of key cancer proteins in acute promyelocytic leukemia
Blood
Saumet, A. and Vetter, G. and Bouttier, M. and Portales-Casamar, E. and Wasserman, W.W. and Maurin, T. and Mari, B. and Barbry, P. and Vallar, L. and Friederich, E. and Arar, K. and Cassinat, B. and Chomienne, C. and Lecellier, C.-H.
DOI: 10.1182/blood-2008-05-158139
2009The PAZAR database of gene regulatory information coupled to the ORCA toolkit for the study of regulatory sequences
Nucleic Acids Research
Portales-Casamar, E. and Arenillas, D. and Lim, J. and Swanson, M.I. and Jiang, S. and McCallum, A. and Kirov, S. and Wasserman, W.W.
DOI: 10.1093/nar/gkn783
2009Identification of a set of genes showing regionally enriched expression in the mouse brain
BMC Neuroscience
D'Souza, C.A. and Chopra, V. and Varhol, R. and Xie, Y.-Y. and Bohacec, S. and Zhao, Y. and Lee, L.L.C. and Bilenky, M. and Portales-Casamar, E. and He, A. and Wasserman, W.W. and Goldowitz, D. and Marra, M.A. and Holt, R.A. and Simpson, E.M. and Jones, S.J.M.
DOI: 10.1186/1471-2202-9-66
2008ORegAnno: An open-access community-driven resource for regulatory annotation
Nucleic Acids Research
Griffith, O.L. and Montgomery, S.B. and Bernier, B. and Chu, B. and Kasaian, K. and Aerts, S. and Mahony, S. and Sleumer, M.C. and Bilenky, M. and Haeussler, M. and Griffith, M. and Gallo, S.M. and Giardine, B. and Hooghe, B. and Van loo, P. and Blanco, E. and Ticoll, A. and Lithwick, S. and Portales-Casamar, E. and Donaldson, I.J. and Robertson, G. and Wadelius, C. and De bleser, P. and Vlieghe, D. and Halfon, M.S. and Wasserman, W. and Hardison, R. and Bergman, C.M. and Jones, S.J.M.
DOI: 10.1093/nar/gkm967
2008Erratum: Trio controls the mature organization of neuronal clusters in the hindbrain (Journal of Neuroscience (2007) (10323-10332))
Journal of Neuroscience
Backer, S. and Hidalgo-Sánchez, M. and Offner, N. and Portales-Casamar, E. and Debant, A. and Fort, P. and Gauthier-Rouvière, C. and Bloch-Gallego, E.
2007Trio controls the mature organization of neuronal clusters in the hindbrain
Journal of Neuroscience
Backer, S. and Hidalgo-Sánchez, M. and Offner, N. and Portales-Casamar, E. and Debant, A. and Fort, P. and Gauthier-Rouvière, C. and Bloch-Gallego, E.
DOI: 10.1523/JNEUROSCI.1102-07.2007
2007PAZAR: A framework for collection and dissemination of cis-regulatory sequence annotation
Genome Biology
Portales-Casamar, E. and Kirov, S. and Lim, J. and Lithwick, S. and Swanson, M.I. and Ticoll, A. and Snoddy, J. and Wasserman, W.W.
DOI: 10.1186/gb-2007-8-10-r207
2007M-cadherin activates Rac1 GTPase through the Rho-GEF Trio during myoblast fusion
Molecular Biology of the Cell
Charrasse, S. and Comunale, F. and Fortier, M. and Portales-Casamar, E. and Debant, A. and Gauthier-Rouvière, C.
DOI: 10.1091/mbc.E06-08-0766
2007Identification of novel neuronal isoforms of the Rho-GEF Trio
Biology of the Cell
Portales-Casamar, E. and Brian?on-Marjollet, A. and Fromont, S. and Triboulet, R. and Debant, A.
DOI: 10.1042/BC20050009
2006Human p63RhoGEF, a novel RhoA-specific guanine nucleotide exchange factor, is localized in cardiac sarcomere.
Souchet M and Portales-Casamar E and Mazurais D and Schmidt S and Léger I and Javré JL and Robert P and Berrebi-Bertrand I and Bril A and Gout B and Debant A and Calmels TP
PubMed: 11861769
02/2002The antidepressant-like effect induced by the sigma
1 (s1 ) receptor agonist igmesine involves modulation of intracellular calcium mobilization
Psychopharmacology
Urani, A. and Romieu, P. and Portales-Casamar, E. and Roman, F.J. and Maurice, T.
DOI: 10.1007/s00213-002-1150-y
2002Human p63RhoGEF, a novel RhoA-specific guanine nucleotide exchange factor, is localized in cardiac sarcomere
Journal of Cell Science
Souchet, M. and Portales-Casamar, E. and Mazurais, D. and Schmidt, S. and Léger, I. and Javré, J.-L. and Robert, P. and Berrebi-Bertrand, I. and Bril, A. and Gout, B. and Debant, A. and Calmels, T.P.G.
2002Trio: A multidomain guanine nucleotide exchange factor for Rho GTPases involved in axonal development,Trio: Un facteur d'échange des GTPases Rho aux multiples facettes impliqué dans le guidage axonal
Medecine/Sciences
Bellanger, J.-M. and Schmidt, S. and Estrach, S. and Portales-Casamar, E. and Diriong, S. and Debant, A.
DOI: 10.1051/medsci/200117121316
2001 - Research
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Integrated Clinical Research Architecture Implementation - Technical Proof-of-Concept
There is a need for translational research infrastructure that enables interoperability between clinical and research systems, as well as between jurisdictions. We propose to demonstrate the utility and feasibility of a Canadian translational research informatics infrastructure by implementing the informatics Integrating Biology & the Bedside (i2b2) data warehousing framework. As a proof-of-concept, we will focus on two academic health institutions from two provinces (BCCHR, BC & WCHRI, AB) and one health domain (diabetes).Research Group MembersAhmed AbuRaed, Postdoctoral Research Fellow
Amy George, Co-op Student
Leena Mazhar
Cindy Ou Yang, Co-op Student
Researchers work to develop post-surgical pediatric pain risk communication tool
Every child is different in terms of their risks for experiencing post-surgical pain. Researchers at BC Children’s Hospital are developing a tool to help accurately predict and communicate an individual child’s risk of experiencing a higher level of post-surgical pain.