Overview

As a Clinician-Scientist, I have a strong interest in conducting translational research that bridges our understanding on the neurobiology of psychiatric illnesses with the clinical applications of this knowledge. I am particularly interested in applying this strategy to severe psychiatric disorders such as refractory psychosis and treatment resistant depression. My clinical practice is actively focused in those most severely afflicted by such conditions, and my research interests are directed at finding novel therapeutic interventions within Non-Invasive Neurostimulation Therapies (NINETs) that can help mitigate the suffering of those with severe and refractory forms of psychosis and depression, including pediatric populations. I strongly believe that understanding NINETs’ mechanism(s) of action is a critical step towards translating this knowledge to clinical practice. More important, translating that knowledge to clinical practice will have a direct, immediate, and positive impact on the life’s of those who struggle and suffer the most devastating forms of mental illness and their families.

Publications

Verbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect?
Neuropsychiatric Disease and Treatment
Fidel Vila-Rodriguez and Donna Lang and Heather Baitz and Kristina Gicas and Allen Thornton and Thomas Ehmann and Geoff N. Smith and Alasdair Barr and Ivan J. Torres and Lili Kopala and G. William MacEwan and Daniel Müller and James Kennedy and William Honer
DOI: 10.2147/NDT.S150488
12/2017

Structural brain markers are differentially associated with neurocognitive profiles in socially marginalized people with multimorbid illness.
Neuropsychology
Kristina M. Gicas and Chantelle J. Giesbrecht and William J. Panenka and Donna J. Lang and Geoffrey N. Smith and Fidel Vila-Rodriguez and Olga Leonova and Andrea A. Jones and Alasdair M. Barr and Ric M. Procyshyn and Tari Buchanan and G. William MacEwan and Wayne Su and A. Talia Vertinsky and Alexander Rauscher and William G. Honer and Allen E. Thornton
DOI: 10.1037/neu0000304
01/2017

A comparison of psychotic symptoms in subjects with methamphetamine versus cocaine dependence
Psychopharmacology
Alexander, P.D. and Gicas, K.M. and Willi, T.S. and Kim, C.N. and Boyeva, V. and Procyshyn, R.M. and Smith, G.N. and Thornton, A.E. and Panenka, W.J. and Jones, A.A. and Vila-Rodriguez, F. and Lang, D.J. and William MacEwan, G. and Honer, W.G. and Barr, A.M.
DOI: 10.1007/s00213-017-4551-7
2017

Prefrontal fatty acid composition in schizophrenia and bipolar disorder: Association with reelin expression
Schizophrenia Research
Beasley, C.L. and Honer, W.G. and Ramos-Miguel, A. and Vila-Rodriguez, F. and Barr, A.M.
DOI: 10.1016/j.schres.2017.05.033
2017

Abnormal functional connectivity within resting-state networks is related to rTMS-based therapy effects of treatment resistant depression: A pilot study
Journal of Affective Disorders
Ge, R. and Blumberger, D.M. and Downar, J. and Daskalakis, Z.J. and Dipinto, A.A. and Tham, J.C.W. and Lam, R. and Vila-Rodriguez, F.
DOI: 10.1016/j.jad.2017.04.060
2017

Dynamic Cross-Entropy
Journal of Neuroscience Methods
Aur, D. and Vila-Rodriguez, F.
DOI: 10.1016/j.jneumeth.2016.10.015
2017

Characterization of white matter integrity deficits in cocaine-dependent individuals with substance-induced psychosis compared with non-psychotic cocaine users
Addiction Biology
Willi, T.S. and Barr, A.M. and Gicas, K. and Lang, D.J. and Vila-Rodriguez, F. and Su, W. and Thornton, A.E. and Leonova, O. and Giesbrecht, C.J. and Procyshyn, R.M. and Rauscher, A. and MacEwan, W.G. and Honer, W.G. and Panenka, W.J.
DOI: 10.1111/adb.12363
2017

Sinus Tachycardia Induced by Methocarbamol and Repetitive Transcranial Magnetic Stimulation (rTMS)
Brain Stimulation
Dobek, C.E. and Dipinto, A.A. and Kuan, A.J. and Lam, R.W. and Blumberger, D.M. and Downar, J. and Daskalakis, Z.J. and Vila-Rodriguez, F.
DOI: 10.1016/j.brs.2015.10.012
2016

Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder: Section 4. Neurostimulation treatments
Canadian Journal of Psychiatry
Milev, R.V. and Giacobbe, P. and Kennedy, S.H. and Blumberger, D.M. and Daskalakis, Z.J. and Downar, J. and Modirrousta, M. and Patry, S. and Vila-Rodriguez, F. and Lam, R.W. and MacQueen, G.M. and Parikh, S.V. and Ravindran, A.V.
DOI: 10.1177/0706743716660033
2016

Index electroconvulsive therapy course to treat severe suicidality and depression in fahr disease
Journal of ECT
Cormack, S. and Chan, P. and Persaud, R. and Vila-Rodriguez, F.
DOI: 10.1097/YCT.0000000000000264
2016

The positive and negative syndrome scale (PANSS): A three-factor model of psychopathology in marginally housed persons with substance dependence and psychiatric illness
PLoS ONE
Giesbrecht, C.J. and O{'}Rourke, N. and Leonova, O. and Strehlau, V. and Paquet, K. and Vila-Rodriguez, F. and Panenka, W.J. and MacEwan, G.W. and Smith, G.N. and Thornton, A.E. and Honer, W.G.
DOI: 10.1371/journal.pone.0151648
2016

Unilateral and bilateral MRI-targeted repetitive transcranial magnetic stimulation for treatmentresistant depression: A randomized controlled study
Journal of Psychiatry and Neuroscience
Blumberger, D.M. and Maller, J.J. and Thomson, L. and Mulsant, B.H. and Rajji, T.K. and Maher, M. and Brown, P.E. and Downar, J. and Vila-Rodriguez, F. and Fitzgerald, P.B. and Daskalakis, Z.J.
DOI: 10.1503/jpn.150265
2016

Factors affecting severity of positive and negative symptoms of psychosis in a polysubstance using population with psychostimulant dependence
Psychiatry Research
Willi, T.S. and Honer, W.G. and Thornton, A.E. and Gicas, K. and Procyshyn, R.M. and Vila-Rodriguez, F. and Panenka, W.J. and Aleksic, A. and Leonova, O. and Jones, A.A. and MacEwan, G.W. and Barr, A.M.
DOI: 10.1016/j.psychres.2016.04.059
2016

Subcortical grey matter alterations in cocaine dependent individuals with substance-induced psychosis compared to non-psychotic cocaine users
Schizophrenia Research
Willi, T.S. and Lang, D.J. and Honer, W.G. and Smith, G.N. and Thornton, A.E. and Panenka, W.J. and Procyshyn, R.M. and Vila-Rodriguez, F. and Su, W. and Vertinsky, A.T. and Leonova, O. and Rauscher, A. and MacEwan, G.W. and Barr, A.M.
DOI: 10.1016/j.schres.2016.08.001
2016

A Tetra-Primer Amplification Refractory System Technique for the Cost-Effective and Novel Genotyping of Eight Single-Nucleotide Polymorphisms of the Catechol-O-Methyltransferase Gene
Genetic Testing and Molecular Biomarkers
Wang, C.K. and Aleksic, A. and Xu, M.S. and Procyshyn, R.M. and Ross, C.J. and Vila-Rodriguez, F. and Ramos-Miguel, A. and Yan, R. and Honer, W.G. and Barr, A.M.
DOI: 10.1089/gtmb.2015.0304
2016

Discovering biomarkers for antidepressant response: Protocol from the Canadian biomarker integration network in depression (CAN-BIND) and clinical characteristics of the first patient cohort
BMC Psychiatry
Lam, R.W. and Milev, R. and Rotzinger, S. and Andreazza, A.C. and Blier, P. and Brenner, C. and Daskalakis, Z.J. and Dharsee, M. and Downar, J. and Evans, K.R. and Farzan, F. and Foster, J.A. and Frey, B.N. and Geraci, J. and Giacobbe, P. and Feilotter, H.E. and Hall, G.B. and Harkness, K.L. and Hassel, S. and Ismail, Z. and Leri, F. and Liotti, M. and MacQueen, G.M. and McAndrews, M.P. and Minuzzi, L. and M{\"u}ller, D.J. and Parikh, S.V. and Placenza, F.M. and Quilty, L.C. and Ravindran, A.V. and Salomons, T.V. and Soares, C.N. and Strother, S.C. and Turecki, G. and Vaccarino, A.L. and Vila-Rodriguez, F. and Kennedy, S.H.
DOI: 10.1186/s12888-016-0785-x
2016

Dimenhydrinate use disorder with chronic psychosis
Journal of Clinical Psychopharmacology
White, R.F. and Honer, W.G. and Procyshyn, R.M. and Vila-Rodriguez, F.
2015

Response trajectories to clozapine in a secondary analysis of pivotal trials support using treatment response to subtype schizophrenia
Canadian journal of psychiatry. Revue canadienne de psychiatrie
Honer, W.G. and Jones, A.A. and Thornton, A.E. and Barr, A.M. and Procyshyn, R.M. and Vila-Rodriguez, F.
2015

NEUROBIOLOGICAL PREDICTORS of RESPONSE to DORSOLATERAL PREFRONTAL CORTEX REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION in DEPRESSION: A SYSTEMATIC REVIEW
Depression and Anxiety
Silverstein, W.K. and Noda, Y. and Barr, M.S. and Vila-Rodriguez, F. and Rajji, T.K. and Fitzgerald, P.B. and Downar, J. and Mulsant, B.H. and Vigod, S. and Daskalakis, Z.J. and Blumberger, D.M.
DOI: 10.1002/da.22424
2015

Electroconvulsive therapy treatment in patients with somatic symptom and related disorders
Neuropsychiatric Disease and Treatment
Leong, K. and Tham, J.C.W. and Scamvougeras, A. and Vila-Rodriguez, F.
DOI: 10.2147/NDT.S90969
2015

Single occurrence of intraictal cessation during index course of electroconvulsive therapy
Journal of ECT
Vila-Rodriguez, F. and Northcott, C. and Tham, J.
DOI: 10.1097/YCT.0000000000000168
2015

Neurobiological mechanisms of repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex in depression: A systematic review
Psychological Medicine
Noda, Y. and Silverstein, W.K. and Barr, M.S. and Vila-Rodriguez, F. and Downar, J. and Rajji, T.K. and Fitzgerald, P.B. and Mulsant, B.H. and Vigod, S.N. and Daskalakis, Z.J. and Blumberger, D.M.
DOI: 10.1017/S0033291715001609
2015

Development of a cost-efficient novel method for rapid, concurrent genotyping of five common single nucleotide polymorphisms of the brain derived neurotrophic factor (BDNF) gene by tetra-primer amplification refractory mutation system
International Journal of Methods in Psychiatric Research
Wang, C.K. and Xu, M.S. and Ross, C.J. and Lo, R. and Procyshyn, R.M. and Vila-Rodriguez, F. and White, R.F. and Honer, W.G. and Barr, A.M.
DOI: 10.1002/mpr.1475
2015

Risk of seizures in transcranial magnetic stimulation: A clinical review to inform consent process focused on bupropion
Neuropsychiatric Disease and Treatment
Dobek, C.E. and Blumberger, D.M. and Downar, J. and Daskalakis, Z.J. and Vila-Rodriguez, F.
DOI: 10.2147/NDT.S91126
2015

Occurrence of postictal a/ß activity during maintenance course of electroconvulsive therapy
Journal of ECT
Schultz, K. and Tham, J. and Chan, P. and Brenner, C. and Northcott, C. and Vila-Rodriguez, F.
DOI: 10.1097/YCT.0000000000000231
2015

Mortality from treatable illnesses in marginally housed adults: A prospective cohort study
BMJ Open
Jones, A.A. and Vila-Rodriguez, F. and Leonova, O. and Langheimer, V. and Lang, D.J. and Barr, A.M. and Procyshyn, R.M. and Smith, G.N. and Schultz, K. and Buchanan, T. and Krausz, M. and Montaner, J.S. and Macewan, G.W. and Rauscher, A. and Panenka, W.J. and Thornton, A.E. and Honer, W.G.
DOI: 10.1136/bmjopen-2015-008876
2015

White matter deficits assessed by diffusion tensor imaging and cognitive dysfunction in psychostimulant users with comorbid human immunodeficiency virus infection Psychiatry
BMC Research Notes
Tang, V.M. and Lang, D.J. and Giesbrecht, C.J. and Panenka, W.J. and Willi, T. and Procyshyn, R.M. and Vila-Rodriguez, F. and Jenkins, W. and Lecomte, T. and Boyda, H.N. and Aleksic, A. and Macewan, G.W. and Honer, W.G. and Barr, A.M.
DOI: 10.1186/s13104-015-1501-5
2015

A case of pseudo-Stauffer's syndrome related to asenapine use
Schizophrenia Research
Schultz, K. and Wang, L. and Barr, A. and Rodriguez, F.V.
DOI: 10.1016/j.schres.2015.10.015
2015

Neuroleptic malignant syndrome: A review from a clinically oriented perspective
Current Neuropharmacology
Tse, L. and Barr, A.M. and Scarapicchia, V. and Vila-Rodriguez, F.
2015

Neurocognitive profiles of marginally housed persons with comorbid substance dependence, viral infection, and psychiatric illness
Journal of Clinical and Experimental Neuropsychology
Gicas, K.M. and Vila-Rodriguez, F. and Paquet, K. and Barr, A.M. and Procyshyn, R.M. and Lang, D.J. and Smith, G.N. and Baitz, H.A. and Giesbrecht, C.J. and Montaner, J.S. and Krajden, M. and Krausz, M. and MacEwan, G.W. and Panenka, W.J. and Honer, W.G. and Thornton, A.E.
DOI: 10.1080/13803395.2014.963519
2014

48 echo T2 myelin imaging of white matter in first-episode schizophrenia: Evidence for aberrant myelination
NeuroImage: Clinical
Lang, D.J.M. and Yip, E. and Mackay, A.L. and Thornton, A.E. and Vila-Rodriguez, F. and Macewan, G.W. and Kopala, L.C. and Smith, G.N. and Laule, C. and Macrae, C.B. and Honer, W.G.
DOI: 10.1016/j.nicl.2014.10.006
2014

Clozapine administered once versus twice daily: Does it make a difference?
Medical Hypotheses
Procyshyn, R.M. and Vila-Rodriguez, F. and Honer, W.G. and Barr, A.M.
DOI: 10.1016/j.mehy.2013.11.043
2014

Idiopathic burning mouth syndrome: A common treatment-refractory somatoform condition responsive to ECT
Psychiatry Research
McGirr, A. and Davis, L. and Vila-Rodriguez, F.
DOI: 10.1016/j.psychres.2014.01.048
2014

Electroconvulsive therapy in patients with deep brain stimulators
Journal of ECT
Vila-Rodriguez, F. and McGirr, A. and Tham, J. and Hadjipavlou, G. and Honey, C.R.
DOI: 10.1097/YCT.0000000000000074
2014

Normal Pressure Hydrocephalus: Etiology, Diagnosis, Treatment, and Putative Nutritional and Lifestyle Risk Factors
Diet and Nutrition in Dementia and Cognitive Decline
McGirr, A. and Vila-Rodriguez, F. and Cusimano, M.D.
DOI: 10.1016/B978-0-12-407824-6.00010-0
2014

Repetitive transcranial magnetic stimulation in depression: A changing landscape
Psychiatric Times
Vila-Rodriguez, F. and Downar, J. and Blumberger, D.M.
2013

The hotel study: Multimorbidity in a community sample living in marginal housing
American Journal of Psychiatry
Vila-Rodriguez, F. and Panenka, W.J. and Lang, D.J. and Thornton, A.E. and Vertinsky, T. and Wong, H. and Barr, A.M. and Procyshyn, R.M. and Sidhu, J.J. and Smith, G.N. and Buchanan, T. and Krajden, M. and Krausz, M. and Montaner, J.S. and MacEwan, G.W. and Honer, W.G.
DOI: 10.1176/appi.ajp.2013.12111439
2013

Chronic benign neutropenia/agranulocytosis associated with non-clozapine antipsychotics
American Journal of Psychiatry
Vila-Rodriguez, F. and Tsang, P. and Barr, A.M.
DOI: 10.1176/appi.ajp.2013.13020215
2013

Personalized risk assessment of drug-related harm is associated with health outcomes
PLoS ONE
Jones, A.A. and Vila-Rodriguez, F. and Panenka, W.J. and Leonova, O. and Strehlau, V. and Lang, D.J. and Thornton, A.E. and Wong, H. and Barr, A.M. and Procyshyn, R.M. and Smith, G.N. and Buchanan, T. and Krajden, M. and Krausz, M. and Montaner, J.S. and MacEwan, G.W. and Nutt, D.J. and Honer, W.G.
DOI: 10.1371/journal.pone.0079754
2013

The relevance of eeg artifact identification: A case of delta-wave blinking due to tardive dyskinesia
Journal of ECT
Vila-Rodriguez, F. and Tham, J.
DOI: 10.1097/YCT.0b013e3182621c4a
2013

Structural brain changes associated with tardive dyskinesia in schizophrenia
British Journal of Psychiatry
Sarr{\'o}, S. and Pomarol-Clotet, E. and Canales-Rodr{\'i}guez, E.J. and Salvador, R. and Gomar, J.J. and Ortiz-Gil, J. and Land{\'i}n-Romero, R. and Vila-Rodr{\'i}guez, F. and Blanch, J. and McKenna, P.J.
DOI: 10.1192/bjp.bp.112.114538
2013

White matter tract abnormalities in first-episode psychosis
Schizophrenia Research
Lee, D.Y. and Smith, G.N. and Su, W. and Honer, W.G. and MacEwan, G.W. and Lapointe, J.S. and Vertinsky, A.T. and Vila-Rodriguez, F. and Kopala, L.C. and Lang, D.J.
DOI: 10.1016/j.schres.2012.06.042
2012

Methamphetamine, perceptual disturbances, and the peripheral drift illusion
American Journal on Addictions
Vila-Rodriguez, F. and MacEwan, G.W. and Honer, W.G.
DOI: 10.1111/j.1521-0391.2011.00161.x
2011

ApoE and cholesterol in schizophrenia and bipolar disorder: Comparison of grey and white matter and relation with APOE genotype
Journal of Psychiatry and Neuroscience
Vila-Rodriguez, F. and Honer, W.G. and Innis, S.M. and Wellington, C.L. and Beasley, C.L.
DOI: 10.1503/jpn.090116
2011

Complex interaction between symptoms, social factors, and gender in social functioning in a community-dwelling sample of schizophrenia
Psychiatric Quarterly
Vila-Rodriguez, F. and Ochoa, S. and Autonell, J. and Usall, J. and Haro, J.M.
DOI: 10.1007/s11126-011-9168-0
2011

Medial prefrontal cortex pathology in schizophrenia as revealed by convergent findings from multimodal imaging
Molecular Psychiatry
Pomarol-Clotet, E. and Canales-Rodr{\'i}guez, E.J. and Salvador, R. and Sarr{\'o}, S. and Gomar, J.J. and Vila, F. and Ortiz-Gil, J. and Iturria-Medina, Y. and Capdevila, A. and McKenna, P.J.
DOI: 10.1038/mp.2009.146
2010

Overall brain connectivity maps show cortico-subcortical abnormalities in schizophrenia
Human Brain Mapping
Salvador, R. and Sarr{\'o}, S. and Gomar, J.J. and Ortiz-Gil, J. and Vila, F. and Capdevila, A. and Bullmore, E. and McKenna, P.J. and Pomarol-Clotet, E.
DOI: 10.1002/hbm.20993
2010

Thalamic shape: A possible endophenotype
Journal of Neuroscience
Vila-Rodriguez, F. and French, L. and Barakauskas, V. and Mead, C.-L. and Khorram, B.
DOI: 10.1523/JNEUROSCI.0553-08.2008
2008

Delusional parasitosis facilitated by web-based dissemination
American Journal of Psychiatry
Vila-Rodriguez, F. and Macewan, B.G.
DOI: 10.1176/appi.ajp.2008.08081283
2008

A simple view of the brain through a frequency-specific functional connectivity measure
NeuroImage
Salvador, R. and Mart{\'i}nez, A. and Pomarol-Clotet, E. and Gomar, J. and Vila, F. and Sarr{\'o}, S. and Capdevila, A. and Bullmore, E.
DOI: 10.1016/j.neuroimage.2007.08.018
2008

Failure to deactivate in the prefrontal cortex in schizophrenia: Dysfunction of the default mode network?
Psychological Medicine
Pomarol-Clotet, E. and Salvador, R. and Sarr{\'o}, S. and Gomar, J. and Vila, F. and Mart{\'i}nez, ?. and Guerrero, A. and Ortiz-Gil, J. and Sans-Sansa, B. and Capdevila, A. and Cebamanos, J.M. and McKenna, P.J.
DOI: 10.1017/S0033291708003565
2008

One year prevalence of mental disorders comorbidity and associated socio-demographic risk factors in the general population of Spain. Results of the ESEMeD-Spain study | Prevalencia-año de la comorbilidad de los trastornos mentales y factores de riesgo sociodemográficos asociados en la población general de España. Resultados del estudio ESEMeD-España.
Actas españolas de psiquiatría
Autonell, J. and Vila, F. and Pinto-Meza, A. and Vilagut, G. and Codony, M. and Almansa, J. and Mu{\~n}oz, P.E. and Torres, J.V. and Alonso, J. and Haro, J.M.
2007