Overview

As a Clinician-Scientist, I have a strong interest in conducting translational research that bridges our understanding on the neurobiology of psychiatric illnesses with the clinical applications of this knowledge. I am particularly interested in applying this strategy to severe psychiatric disorders such as refractory psychosis and treatment resistant depression. My clinical practice is actively focused in those most severely afflicted by such conditions, and my research interests are directed at finding novel therapeutic interventions within Non-Invasive Neurostimulation Therapies (NINETs) that can help mitigate the suffering of those with severe and refractory forms of psychosis and depression, including pediatric populations. I strongly believe that understanding NINETs’ mechanism(s) of action is a critical step towards translating this knowledge to clinical practice. More important, translating that knowledge to clinical practice will have a direct, immediate, and positive impact on the life’s of those who struggle and suffer the most devastating forms of mental illness and their families.

Publications

Impact of cannabis mass gathering events on mental health and health service utilization
Patrick Lombardo and Andrew Lim and Andrea Jones and Daniel Vigo and William G Honer and Jennifer Duff and G William MacEwan and Fidel Vila-Rodriguez
DOI: 10.1101/2020.04.20.20073387
04/2020

Evaluation of the effects of rTMS on self-reported quality of life and disability in treatment-resistant depression: A THREE-D study.
Journal of affective disorders
DOI: 10.1016/j.jad.2020.03.002
PubMed: 32174470
03/2020

Towards Competency-Based Medical Education in Neurostimulation.
Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry
DOI: 10.1007/s40596-020-01195-z
PubMed: 32048176
02/2020

Caution When Continuing Benzodiazepines During rTMS: Response to Hunter and Leuchter.
The American journal of psychiatry
DOI: 10.1176/appi.ajp.2019.19060603r
PubMed: 32008395
02/2020

Cognitive decline and mortality in a community-based sample of homeless and precariously housed adults: 9-year prospective study.
BJPsych open
DOI: 10.1192/bjo.2020.3
PubMed: 32043436
02/2020

Mapping Subcortical Brain Alterations in 22q11.2 Deletion Syndrome: Effects of Deletion Size and Convergence With Idiopathic Neuropsychiatric Illness.
The American journal of psychiatry
DOI: 10.1176/appi.ajp.2019.19060583
PubMed: 32046535
02/2020

Use of Machine Learning for Predicting Escitalopram Treatment Outcome From Electroencephalography Recordings in Adult Patients With Depression.
JAMA network open
DOI: 10.1001/jamanetworkopen.2019.18377
PubMed: 31899530
01/2020

Functional connectivity of the anterior cingulate cortex predicts treatment outcome for rTMS in treatment-resistant depression at 3-month follow-up
Brain Stimulation
Ruiyang Ge and Jonathan Downar and Daniel M. Blumberger and Zafiris J. Daskalakis and Fidel Vila-Rodriguez
DOI: 10.1016/j.brs.2019.10.012
01/2020

Cardiovascular differences between sham and active iTBS related to treatment response in MDD
Brain Stimulation
Tabitha A. Iseger and Martijn Arns and Jonathan Downar and Daniel M. Blumberger and Zafiris J. Daskalakis and Fidel Vila-Rodriguez
DOI: 10.1016/j.brs.2019.09.016
01/2020

Accelerated magnetic seizure therapy (aMST) for treatment of major depressive disorder: A pilot study.
Journal of affective disorders
DOI: 10.1016/j.jad.2019.12.022
PubMed: 32056753
12/2019

Mixing Apples and Oranges in Assessing Outcomes of Repetitive Transcranial Stimulation Meta-Analyses.
Psychotherapy and psychosomatics
DOI: 10.1159/000504653
PubMed: 31794971
12/2019

International Consortium on the Genetics of Electroconvulsive Therapy and Severe Depressive Disorders (Gen-ECT-ic).
European archives of psychiatry and clinical neuroscience
DOI: 10.1007/s00406-019-01087-w
PubMed: 31802253
12/2019

Impact of prior treatment on remission with intermittent theta burst versus high-frequency repetitive transcranial magnetic stimulation in treatment resistant depression
Brain Stimulation
Jonathan H. Hsu and Jonathan Downar and Fidel Vila-Rodriguez and Zafiris J. Daskalakis and Daniel M. Blumberger
DOI: 10.1016/j.brs.2019.07.011
11/2019

Effects of Ketamine Anesthesia on Efficacy, Tolerability, Seizure Response, and Neurocognitive Outcomes in Electroconvulsive Therapy: A Comprehensive Meta-analysis of Double-Blind Randomized Controlled Trials.
The journal of ECT
DOI: 10.1097/yct.0000000000000632
PubMed: 31725054
11/2019

Considerable evidence supports rTMS for treatment-resistant depression.
Journal of affective disorders
DOI: 10.1016/j.jad.2019.11.017
PubMed: 31727396
11/2019

Interleaved Transcranial Magnetic Stimulation and Functional Magnetic Resonance Imaging: A Translational Tool
Clinical Pharmacology & Therapeutics
Fidel Vila-Rodriguez and Ruiyang Ge and David Long
DOI: 10.1002/cpt.1575
10/2019

Longer Repetition Time Proton MR Spectroscopy Shows Increasing Hippocampal and Parahippocampal Metabolite Concentrations with Aging
Journal of Neuroimaging
Leo Sporn and Erin L. MacMillan and Ruiyang Ge and Kyle Greenway and Fidel Vila-Rodriguez and Cornelia Laule
DOI: 10.1111/jon.12648
09/2019

Implementation of intermittent theta burst stimulation compared to conventional repetitive transcranial magnetic stimulation in patients with treatment resistant depression: A cost analysis.
PloS one
DOI: 10.1371/journal.pone.0222546
PubMed: 31513675
09/2019

The Canadian Biomarker Integration Network in Depression (CAN-BIND): magnetic resonance imaging protocols
Journal of psychiatry & neuroscience : JPN
DOI: 10.1503/jpn.180036
PubMed: 30840428
07/2019

Cognitive profiles and associated structural brain networks in a multimorbid sample of marginalized adults.
PloS one
DOI: 10.1371/journal.pone.0218201
PubMed: 31194834
06/2019

A comparison of regional brain volumes and white matter connectivity in subjects with stimulant induced psychosis versus schizophrenia.
Psychopharmacology
DOI: 10.1007/s00213-019-05298-w
PubMed: 31230145
06/2019

Accelerated Magnetic Seizure Therapy for Treatment of Major Depressive Disorder: A Report of 3 Cases.
The journal of ECT
DOI: 10.1097/yct.0000000000000521
PubMed: 29979250
06/2019

Volumes of the Hippocampal Formation Differentiate Component Processes of Memory in a Community Sample of Homeless and Marginally Housed Persons.
Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
DOI: 10.1093/arclin/acy066
PubMed: 30407496
06/2019

Parcellation of the human hippocampus based on gray matter volume covariance: Replicable results on healthy young adults.
Human brain mapping
DOI: 10.1002/hbm.24628
PubMed: 31115118
05/2019

Lifesaving Electroconvulsive Therapy for a Child With Autism Spectrum Disorder, Severe Self-Injurious Behavior, and Neuroleptic Malignant Syndrome.
The journal of ECT
DOI: 10.1097/yct.0000000000000598
PubMed: 31022044
04/2019

Functional disconnectivity of the hippocampal network and neural correlates of memory impairment in treatment-resistant depression.
Journal of affective disorders
DOI: 10.1016/j.jad.2019.04.096
PubMed: 31060011
04/2019

Repetitive transcranial magnetic stimulation for depression - Authors' reply.
Lancet (London, England)
DOI: 10.1016/s0140-6736(18)32837-x
PubMed: 30712896
02/2019

Symptomatic and Functional Outcomes and Early Prediction of Response to Escitalopram Monotherapy and Sequential Adjunctive Aripiprazole Therapy in Patients With Major Depressive Disorder: A CAN-BIND-1 Report.
The Journal of clinical psychiatry
DOI: 10.4088/jcp.18m12202
PubMed: 30840787
02/2019

Trajectories of Response to Dorsolateral Prefrontal rTMS in Major Depression: A THREE-D Study.
The American journal of psychiatry
DOI: 10.1176/appi.ajp.2018.18091096
PubMed: 30764649
02/2019

Diffusion tensor imaging of neurocognitive profiles in a community cohort living in marginal housing.
Brain and behavior
DOI: 10.1002/brb3.1233
PubMed: 30724486
02/2019

Intermittent theta burst stimulation for major depression during pregnancy.
Brain stimulation
DOI: 10.1016/j.brs.2019.01.003
PubMed: 30665752
01/2019

Structural network integrity of the central executive network is associated with the therapeutic effect of rTMS in treatment resistant depression.
Progress in neuro-psychopharmacology & biological psychiatry
DOI: 10.1016/j.pnpbp.2019.01.012
PubMed: 30685322
01/2019

Non-linear Entropy Analysis in EEG to Predict Treatment Response to Repetitive Transcranial Magnetic Stimulation in Depression.
Frontiers in Pharmacology
DOI: 10.3389/fphar.2018.01188
PubMed: 30425640
10/2018

Large-scale mapping of cortical alterations in 22q11.2 deletion syndrome: Convergence with idiopathic psychosis and effects of deletion size.
Molecular psychiatry
DOI: 10.1038/s41380-018-0078-5
PubMed: 29895892
06/2018

Impaired neuroplasticity in the prefrontal cortex in depression indexed through paired associative stimulation.
Depression and anxiety
DOI: 10.1002/da.22738
PubMed: 29637656
04/2018

Clinical and functional characteristics of young adults living in single room occupancy housing: preliminary findings from a 10-year longitudinal study.
Canadian journal of public health = Revue canadienne de sante publique
DOI: 10.17269/s41997-018-0087-9
PubMed: 29981045
04/2018

Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial.
Lancet (London, England)
DOI: 10.1016/s0140-6736(18)30295-2
PubMed: 29726344
04/2018

Verbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect?
Neuropsychiatric Disease and Treatment
Fidel Vila-Rodriguez and Donna Lang and Heather Baitz and Kristina Gicas and Allen Thornton and Thomas Ehmann and Geoff N. Smith and Alasdair Barr and Ivan J. Torres and Lili Kopala and G. William MacEwan and Daniel Müller and James Kennedy and William Honer
DOI: 10.2147/NDT.S150488
12/2017

Abnormal Functional Connectivity of Frontopolar Subregions in Treatment-Nonresponsive Major Depressive Disorder.
Biological psychiatry. Cognitive neuroscience and neuroimaging
DOI: 10.1016/j.bpsc.2017.12.003
PubMed: 29628066
12/2017

Early symptom improvement at 10 sessions as a predictor of rTMS treatment outcome in major depression.
Brain stimulation
DOI: 10.1016/j.brs.2017.10.010
PubMed: 29107623
10/2017

Traumatic Brain Injury in a Community-Based Cohort of Homeless and Vulnerably Housed Individuals.
Journal of neurotrauma
DOI: 10.1089/neu.2017.5076
PubMed: 28741437
09/2017

Standardization of electroencephalography for multi-site, multi-platform and multi-investigator studies: insights from the canadian biomarker integration network in depression.
Scientific reports
DOI: 10.1038/s41598-017-07613-x
PubMed: 28785082
08/2017

A sparse representation-based method for parcellation of the resting brain and its application to treatment-resistant major depressive disorder.
Journal of neuroscience methods
DOI: 10.1016/j.jneumeth.2017.07.017
PubMed: 28739164
07/2017

Structural brain markers are differentially associated with neurocognitive profiles in socially marginalized people with multimorbid illness.
Neuropsychology
Kristina M. Gicas and Chantelle J. Giesbrecht and William J. Panenka and Donna J. Lang and Geoffrey N. Smith and Fidel Vila-Rodriguez and Olga Leonova and Andrea A. Jones and Alasdair M. Barr and Ric M. Procyshyn and Tari Buchanan and G. William MacEwan and Wayne Su and A. Talia Vertinsky and Alexander Rauscher and William G. Honer and Allen E. Thornton
DOI: 10.1037/neu0000304
01/2017

A comparison of psychotic symptoms in subjects with methamphetamine versus cocaine dependence
Psychopharmacology
DOI: 10.1007/s00213-017-4551-7
2017

Abnormal functional connectivity within resting-state networks is related to rTMS-based therapy effects of treatment resistant depression: A pilot study
Journal of Affective Disorders
DOI: 10.1016/j.jad.2017.04.060
2017

Prefrontal fatty acid composition in schizophrenia and bipolar disorder: Association with reelin expression
Schizophrenia Research
DOI: 10.1016/j.schres.2017.05.033
2017

Dynamic Cross-Entropy
Journal of Neuroscience Methods
DOI: 10.1016/j.jneumeth.2016.10.015
2017

Characterization of white matter integrity deficits in cocaine-dependent individuals with substance-induced psychosis compared with non-psychotic cocaine users
Addiction Biology
DOI: 10.1111/adb.12363
2017

A Tetra-Primer Amplification Refractory System Technique for the Cost-Effective and Novel Genotyping of Eight Single-Nucleotide Polymorphisms of the Catechol-O-Methyltransferase Gene
Genetic Testing and Molecular Biomarkers
DOI: 10.1089/gtmb.2015.0304
2016

Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder: Section 4. Neurostimulation treatments
Canadian Journal of Psychiatry
DOI: 10.1177/0706743716660033
2016

Index electroconvulsive therapy course to treat severe suicidality and depression in fahr disease
Journal of ECT
DOI: 10.1097/YCT.0000000000000264
2016

The positive and negative syndrome scale (PANSS): A three-factor model of psychopathology in marginally housed persons with substance dependence and psychiatric illness
PLoS ONE
DOI: 10.1371/journal.pone.0151648
2016

Unilateral and bilateral MRI-targeted repetitive transcranial magnetic stimulation for treatmentresistant depression: A randomized controlled study
Journal of Psychiatry and Neuroscience
DOI: 10.1503/jpn.150265
2016

Factors affecting severity of positive and negative symptoms of psychosis in a polysubstance using population with psychostimulant dependence
Psychiatry Research
DOI: 10.1016/j.psychres.2016.04.059
2016

Discovering biomarkers for antidepressant response: Protocol from the Canadian biomarker integration network in depression (CAN-BIND) and clinical characteristics of the first patient cohort
BMC Psychiatry
DOI: 10.1186/s12888-016-0785-x
2016

Subcortical grey matter alterations in cocaine dependent individuals with substance-induced psychosis compared to non-psychotic cocaine users
Schizophrenia Research
DOI: 10.1016/j.schres.2016.08.001
2016

Sinus Tachycardia Induced by Methocarbamol and Repetitive Transcranial Magnetic Stimulation (rTMS)
Brain Stimulation
DOI: 10.1016/j.brs.2015.10.012
2016

Dimenhydrinate use disorder with chronic psychosis
Journal of Clinical Psychopharmacology
2015

Neurobiological mechanisms of repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex in depression: A systematic review
Psychological Medicine
DOI: 10.1017/S0033291715001609
2015

Response trajectories to clozapine in a secondary analysis of pivotal trials support using treatment response to subtype schizophrenia
Canadian journal of psychiatry. Revue canadienne de psychiatrie
2015

Occurrence of postictal a/ß activity during maintenance course of electroconvulsive therapy
Journal of ECT
DOI: 10.1097/YCT.0000000000000231
2015

NEUROBIOLOGICAL PREDICTORS of RESPONSE to DORSOLATERAL PREFRONTAL CORTEX REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION in DEPRESSION: A SYSTEMATIC REVIEW
Depression and Anxiety
DOI: 10.1002/da.22424
2015

Electroconvulsive therapy treatment in patients with somatic symptom and related disorders
Neuropsychiatric Disease and Treatment
DOI: 10.2147/NDT.S90969
2015

Single occurrence of intraictal cessation during index course of electroconvulsive therapy
Journal of ECT
DOI: 10.1097/YCT.0000000000000168
2015

Development of a cost-efficient novel method for rapid, concurrent genotyping of five common single nucleotide polymorphisms of the brain derived neurotrophic factor (BDNF) gene by tetra-primer amplification refractory mutation system
International Journal of Methods in Psychiatric Research
DOI: 10.1002/mpr.1475
2015

Risk of seizures in transcranial magnetic stimulation: A clinical review to inform consent process focused on bupropion
Neuropsychiatric Disease and Treatment
DOI: 10.2147/NDT.S91126
2015

Neuroleptic malignant syndrome: A review from a clinically oriented perspective
Current Neuropharmacology
2015

Mortality from treatable illnesses in marginally housed adults: A prospective cohort study
BMJ Open
DOI: 10.1136/bmjopen-2015-008876
2015

White matter deficits assessed by diffusion tensor imaging and cognitive dysfunction in psychostimulant users with comorbid human immunodeficiency virus infection Psychiatry
BMC Research Notes
DOI: 10.1186/s13104-015-1501-5
2015

A case of pseudo-Stauffer's syndrome related to asenapine use
Schizophrenia Research
DOI: 10.1016/j.schres.2015.10.015
2015

Neurocognitive profiles of marginally housed persons with comorbid substance dependence, viral infection, and psychiatric illness
Journal of Clinical and Experimental Neuropsychology
DOI: 10.1080/13803395.2014.963519
2014

Clozapine administered once versus twice daily: Does it make a difference?
Medical Hypotheses
DOI: 10.1016/j.mehy.2013.11.043
2014

48 echo T2 myelin imaging of white matter in first-episode schizophrenia: Evidence for aberrant myelination
NeuroImage: Clinical
DOI: 10.1016/j.nicl.2014.10.006
2014

Idiopathic burning mouth syndrome: A common treatment-refractory somatoform condition responsive to ECT
Psychiatry Research
DOI: 10.1016/j.psychres.2014.01.048
2014

Electroconvulsive therapy in patients with deep brain stimulators
Journal of ECT
DOI: 10.1097/YCT.0000000000000074
2014

Normal Pressure Hydrocephalus: Etiology, Diagnosis, Treatment, and Putative Nutritional and Lifestyle Risk Factors
Diet and Nutrition in Dementia and Cognitive Decline
DOI: 10.1016/B978-0-12-407824-6.00010-0
2014

Repetitive transcranial magnetic stimulation in depression: A changing landscape
Psychiatric Times
2013

Chronic benign neutropenia/agranulocytosis associated with non-clozapine antipsychotics
American Journal of Psychiatry
DOI: 10.1176/appi.ajp.2013.13020215
2013

The hotel study: Multimorbidity in a community sample living in marginal housing
American Journal of Psychiatry
DOI: 10.1176/appi.ajp.2013.12111439
2013

Structural brain changes associated with tardive dyskinesia in schizophrenia
British Journal of Psychiatry
DOI: 10.1192/bjp.bp.112.114538
2013

The relevance of eeg artifact identification: A case of delta-wave blinking due to tardive dyskinesia
Journal of ECT
DOI: 10.1097/YCT.0b013e3182621c4a
2013

Personalized risk assessment of drug-related harm is associated with health outcomes
PLoS ONE
DOI: 10.1371/journal.pone.0079754
2013

White matter tract abnormalities in first-episode psychosis
Schizophrenia Research
DOI: 10.1016/j.schres.2012.06.042
2012

Complex interaction between symptoms, social factors, and gender in social functioning in a community-dwelling sample of schizophrenia
Psychiatric Quarterly
DOI: 10.1007/s11126-011-9168-0
2011

Methamphetamine, perceptual disturbances, and the peripheral drift illusion
American Journal on Addictions
DOI: 10.1111/j.1521-0391.2011.00161.x
2011

ApoE and cholesterol in schizophrenia and bipolar disorder: Comparison of grey and white matter and relation with APOE genotype
Journal of Psychiatry and Neuroscience
DOI: 10.1503/jpn.090116
2011

Medial prefrontal cortex pathology in schizophrenia as revealed by convergent findings from multimodal imaging
Molecular Psychiatry
DOI: 10.1038/mp.2009.146
2010

Overall brain connectivity maps show cortico-subcortical abnormalities in schizophrenia
Human Brain Mapping
DOI: 10.1002/hbm.20993
2010

Failure to deactivate in the prefrontal cortex in schizophrenia: Dysfunction of the default mode network?
Psychological Medicine
DOI: 10.1017/S0033291708003565
2008

A simple view of the brain through a frequency-specific functional connectivity measure
NeuroImage
DOI: 10.1016/j.neuroimage.2007.08.018
2008

Thalamic shape: A possible endophenotype
Journal of Neuroscience
DOI: 10.1523/JNEUROSCI.0553-08.2008
2008

Delusional parasitosis facilitated by web-based dissemination
American Journal of Psychiatry
DOI: 10.1176/appi.ajp.2008.08081283
2008

One year prevalence of mental disorders comorbidity and associated socio-demographic risk factors in the general population of Spain. Results of the ESEMeD-Spain study | Prevalencia-año de la comorbilidad de los trastornos mentales y factores de riesgo sociodemográficos asociados en la población general de España. Resultados del estudio ESEMeD-España.
Actas españolas de psiquiatría
2007