My area of research is congenital heart disease. The focus is a) the use of echocardiography to assess cardiac and vascular function with and without exercise and also b) fetal echocardiography.
Stress Echocardiographic Evaluation for D-Transposition of the Great Arteries after Atrial Redirection: Unmasking Early Signs of Myocardial Dysfunction and Baffle Stenosis.
Dvir-Orgad M, Anand M, De Souza AM, Zadorsky MT, Kiess MC, Potts JE, Sandor GG
Noninvasive Assessment of Vascular Function in Postoperative Cardiovascular Disease (Coarctation of the Aorta, Tetralogy of Fallot, and Transposition of the Great Arteries).
Mivelaz Y, Leung MT, Zadorsky MT, De Souza AM, Potts JE, Sandor GG
Characterization of Myocardial Repolarization Reserve in Adolescent Females With Anorexia Nervosa.
Padfield GJ, Escudero CA, DeSouza AM, Steinberg C, Gibbs K, Puyat JH, Lam PY, Sanatani S, Sherwin E, Potts JE, Sandor G, Krahn AD
An Echocardiographic Study of Left Ventricular Size and Cardiac Function in Adolescent Females with Anorexia Nervosa.
Escudero CA, Potts JE, Lam PY, De Souza AM, Mugford GJ, Sandor GG
Aortic and Cardiac Structure and Function Using High-Resolution Echocardiography and Optical Coherence Tomography in a Mouse Model of Marfan Syndrome.
Lee L, Cui JZ, Cua M, Esfandiarei M, Sheng X, Chui WA, Xu MH, Sarunic MV, Beg MF, van Breemen C, Sandor GG, Tibbits GF
Design and rationale of a prospective, collaborative meta-analysis of all randomized controlled trials of angiotensin receptor antagonists in Marfan syndrome, based on individual patient data: A report from the Marfan Treatment Trialists' Collaboration.
Pitcher A, Emberson J, Lacro RV, Sleeper LA, Stylianou M, Mahony L, Pearson GD, Groenink M, Mulder BJ, Zwinderman AH, De Backer J, De Paepe AM, Arbustini E, Erdem G, Jin XY, Flather MD, Mullen MJ, Child AH, Forteza A, Evangelista A
Obesity and arterial stiffness in children: systematic review and meta-analysis.
Cote AT, Phillips AA, Harris KC, Sandor GG, Panagiotopoulos C, Devlin AM
A randomized, double blind pilot study to assess the effects of losartan vs. atenolol on the biophysical properties of the aorta in patients with Marfan and Loeys-Dietz syndromes.
Sandor GG, Alghamdi MH, Raffin LA, Potts MT, Williams LD, Potts JE, Kiess M, van Breemen C
Genetic variants in SLC22A17 and SLC22A7 are associated with anthracycline-induced cardiotoxicity in children.
Visscher H, Rassekh SR, Sandor GS, Caron HN, van Dalen EC, Kremer LC, van der Pal HJ, Rogers PC, Rieder MJ, Carleton BC, Hayden MR, Ross CJ, CPNDS consortium
Response to: echocardiography assessment of the aorta in children with chronic kidney disease.
Alghamdi M, De Souza AM, White CT, Potts MT, Warady BA, Furth SL, Kimball TR, Potts JE, Sandor GG
Noninvasive assessment of vascular function and hydraulic power and efficiency in pediatric Fontan patients.
Myers KA, Leung MT, Terri Potts M, Potts JE, Sandor GG
Echo-Doppler assessment of arterial stiffness in pediatric patients with Kawasaki disease.
AlHuzaimi A, Al Mashham Y, Potts JE, De Souza AM, Sandor GG
Validation of variants in SLC28A3 and UGT1A6 as genetic markers predictive of anthracycline-induced cardiotoxicity in children.
Visscher H, Ross CJ, Rassekh SR, Sandor GS, Caron HN, van Dalen EC, Kremer LC, van der Pal HJ, Rogers PC, Rieder MJ, Carleton BC, Hayden MR, CPNDS Consortium
Physical activity recommendations for patients with electrophysiologic and structural congenital heart disease: a survey of Canadian health care providers.
Roston TM, De Souza AM, Sandor GG, Sanatani S, Potts JE
Echo-Doppler assessment of the biophysical properties of the aorta in children with chronic kidney disease.
Alghamdi M, De Souza AM, White CT, Potts MT, Warady BA, Furth SL, Kimball TR, Potts JE, Sandor GG
Population-based review of tetralogy of Fallot with absent pulmonary valve: is prenatal diagnosis really associated with a poor prognosis?
Mivelaz Y, Lim KI, Templeton C, Campbell AI, Potts JE, Sandor GG
Biophysical properties of the aorta and left ventricle and exercise capacity in obese children.
Harris KC, Al Saloos HA, De Souza AM, Sanatani S, Hinchliffe M, Potts JE, Sandor GG
Pharmacogenomic prediction of anthracycline-induced cardiotoxicity in children.
Visscher H, Ross CJ, Rassekh SR, Barhdadi A, Dubé MP, Al-Saloos H, Sandor GS, Caron HN, van Dalen EC, Kremer LC, van der Pal HJ, Brown AM, Rogers PC, Phillips MS, Rieder MJ, Carleton BC, Hayden MR, Canadian Pharmacogenomics Network for Drug Safety Consortium
Exercise-induced intrapulmonary arteriovenous shunt in healthy women.
Kennedy JM, Foster GE, Koehle MS, Potts JE, Sandor GG, Potts MT, Houghton KM, Henderson WR, Sheel AW
Successful treatment of acute lymphoblastic leukemia in a child with trisomy 21 and complex congenital heart disease with mechanical prosthetic valve.
Alvi S, Shereck E, Heran MK, Sandor GG, Rassekh SR
Serial measurements of exercise performance in pediatric heart transplant patients using stress echocardiography.
Yeung JP, Human DG, Sandor GG, De Souza AM, Potts JE
Primary pulmonary arterial hypertension and autoimmune polyendocrine syndrome in a pediatric patient.
Alghamdi MH, Steinraths M, Panagiotopoulos C, Potts JE, Sandor GG
Early changes in the biophysical properties of the aorta in pre-adolescent children born small for gestational age.
Bradley TJ, Potts JE, Lee SK, Potts MT, De Souza AM, Sandor GG
Does biventricular pacing improve hemodynamics in children undergoing routine congenital heart surgery?
Jeewa A, Pitfield AF, Potts JE, Soulikias W, DeSouza ES, Hollinger AJ, Sandor GG, LeBlanc JG, Campbell AM, Sanatani S
Facilitated cardiac recovery in fulminant myocarditis: pediatric use of the Impella LP 5.0 pump.
Andrade JG, Al-Saloos H, Jeewa A, Sandor GG, Cheung A
Abnormal flow in the posterior descending artery: an echo Doppler clue to the anomalous origin of left anterior descending coronary artery from the pulmonary trunk.
Myers KA, Potts MT, Sandor GG
A novel method to estimate the aortic pressure waveform using B-mode ultrasound images acquired from a suprasternal view.
Leung MT, Dumont GA, Sandor GG, Potts M, Potts JE
Echocardiographic Doppler demonstrates increasing aortic pulse wave velocity (PWV) in adult patients with renal disease.
Sandor GG, Potts JE, Bradley TJ
Loss of elastic fiber integrity and reduction of vascular smooth muscle contraction resulting from the upregulated activities of matrix metalloproteinase-2 and -9 in the thoracic aortic aneurysm in Marfan syndrome.
Chung AW, Au Yeung K, Sandor GG, Judge DP, Dietz HC, van Breemen C
A stress echocardiography study of cardiac function during progressive exercise in pediatric oncology patients treated with anthracyclines.
De Souza AM, Potts JE, Potts MT, De Souza ES, Rowland TW, Pritchard SL, Sandor GG
Endothelial dysfunction and compromised eNOS/Akt signaling in the thoracic aorta during the progression of Marfan syndrome.
Chung AW, Au Yeung K, Cortes SF, Sandor GG, Judge DP, Dietz HC, van Breemen C
Device closure of a secundum atrial septal defect in a 4-month-old infant with a marginal left ventricle following coarctation repair.
Jean-St-Michel E, Hosking MC, Potts JE, Sandor GG
Right-sided cardiac involvement in osteogenesis imperfecta.
Khashu M, Pelligra G, Sandor GG, Singh AJ
Is the nuchal index increased in fetuses with congenital structural heart defects?
Dahlgren LS, Duncan WJ, Farquarhson DF, Sandor GS, Skoll MA, Tessier F, Lim KI
Echocardiographic Doppler assessment of the biophysical properties of the aorta in pediatric patients with the Marfan syndrome.
Bradley TJ, Potts JE, Potts MT, DeSouza AM, Sandor GG
Repair in infancy of right aortic arch with aberrant left brachiocephalic artery in the setting of a variant of the hypoplastic left heart syndrome.
Sett SS, Mawson JB, Sandor GG
Diagnosis and outcome of dextrocardia diagnosed in the fetus.
Walmsley R, Hishitani T, Sandor GG, Lim K, Duncan W, Tessier F, Farquharson DF, Potts JE
Parents' perspectives on decision making after antenatal diagnosis of congenital heart disease.
Rempel GR, Cender LM, Lynam MJ, Sandor GG, Farquharson D
Myocardial contractility in premature neonates with and without patent ductus arteriosus.
Barlow AJ, Ward C, Webber SA, Sinclair BG, Potts JE, Sandor GG
A novel Doppler echocardiographic method of measuring the biophysical properties of the aorta in pediatric patients.
Sandor GG, Hishitani T, Petty RE, Potts MT, Desouza A, Desouza E, Potts JE
Coronary arterial abnormalities in pulmonary atresia with intact ventricular septum diagnosed during fetal life.
Sandor GG, Cook AC, Sharland GK, Ho SY, Potts JE, Anderson RH
Pulmonary atresia with intact ventricular septum: range of morphology in a population-based study.
Daubeney PE, Delany DJ, Anderson RH, Sandor GG, Slavik Z, Keeton BR, Webber SA, United Kingdom and Ireland Collaborative Study of Pulmonary Atresia with Intact Ventricular Septum
"Masked" pulmonary venous obstruction in patients with isomerism of the right atrial appendages: an overstated association.
Becket Mahnke C, Sandor GG, Boyle GJ, Webber SA
Postpericardiotomy syndrome: no evidence for a viral etiology.
Webber SA, Wilson NJ, Junker AK, Byrne SK, Perry A, Thomas EE, Book L, Tipple M, Patterson MW, Sandor GG
Echocardiography and pulmonary function testing in childhood onset systemic lupus erythematosus.
Al-Abbad AJ, Cabral DA, Sanatani S, Sandor GG, Seear M, Petty RE, Malleson PN
Cardiovascular responses to exercise in children and adolescents with myocardial dysfunction.
Rowland T, Potts J, Potts T, Son-Hing J, Harbison G, Sandor G
[Standards of pediatric echocardiography]
Smallhorn JF, Fouron JC, Robertson MA, Sandor G
Standards for training in pediatric echocardiography. Canadian Cardiovascular Society.
Fouron JC, Robertson MA, Sandor G
Differences in dose scheduling as a factor in the etiology of anthracycline-induced cardiotoxicity in Ewing sarcoma patients.
Kakadekar AP, Sandor GG, Fryer C, Chan KW, Rogers PC, Pritchard S, Popov R
Effectiveness of primary level antenatal screening for severe congenital heart disease: a population-based assessment.
Sinclair BG, Sandor GG, Farquharson DF
Short- and long-term variability of echocardiographic stress-velocity indexes of cardiac function in a pediatric population.
Sandor GG, Webber SA, Popov RO, DeSouza E, Johnston B
Influence of competitive pulmonary blood flow on the bidirectional superior cavopulmonary shunt. A multi-institutional study.
Webber SA, Horvath P, LeBlanc JG, Slavik Z, Lamb RK, Monro JL, Reich O, Hruda J, Sandor GG, Keeton BR
Pulmonary artery banding is not contraindicated in double inlet left ventricle with transposition and aortic arch obstruction.
Webber SA, LeBlanc JG, Keeton BR, Salmon AP, Sandor GG, Lamb RK, Monro JL
Guidelines for monitoring of anthracycline cardiomyopathy: a rebuttal.
Steinherz LJ, Graham T, Hurwitz R, Sondheimer HM, Schaffer EM, Schwartz RG, Sandor G, Benson L, Williams R
Double-blind placebo-controlled trial of corticosteroids in children with postpericardiotomy syndrome.
Wilson NJ, Webber SA, Patterson MW, Sandor GG, Tipple M, LeBlanc J
Pulmonary vascular disease in neonates with transposition of the great arteries and intact ventricular septum.
Kumar A, Taylor GP, Sandor GG, Patterson MW
Immunogenicity of Haemophilus influenzae type b conjugate vaccine in children with congenital asplenia.
Webber SA, Sandor GG, Patterson MW, Mitchell LA, Scheifele D, Ochnio JJ, McVerry PH
Autoantibody production after cardiopulmonary bypass with special reference to postpericardiotomy syndrome.
Webber SA, Wilson NJ, Fung MY, Malleson PN, Petty RE, Patterson MW, Sandor GG
Early prediction of anthracycline cardiomyopathy using standard M-mode and digitized echocardiography.
Sandor GG, Puterman M, Rogers P, Chan KW, Pritchard S, Popov R
Doppler echocardiographic observations of diastolic trans-septal flow through small ventricular septal defects.
Webber SA, Sandor GG, Patterson MW
Guidelines for cardiac monitoring of children during and after anthracycline therapy: report of the Cardiology Committee of the Childrens Cancer Study Group.
Steinherz LJ, Graham T, Hurwitz R, Sondheimer HM, Schwartz RG, Shaffer EM, Sandor G, Benson L, Williams R
Rate-corrected mean velocity of fiber shortening-stress at peak systole as a load-independent measure of contractility.
Sandor GG, Popov R, De Souza E, Morris S, Johnston B
The clinical value and risks of lung biopsy in children with congenital heart disease.
Wilson NJ, Seear MD, Taylor GP, LeBlanc JG, Sandor GG
Assessment of bedside umbilical vein balloon septostomy using two-dimensional echocardiographic guidance in transposition of great arteries.
D'Orsogna L, Lam J, Sandor GG, Patterson MW
Influence of echocardiography in pre-operative cardiac catheterization in congenital heart disease.
D'Orsogna L, Sandor GG, Patterson MW, Ashmore PG, LeBlanc J, Culham JA
Role of prenatal detection of cardiac tumours in the diagnosis of tuberous sclerosis--report of two cases.
Chitayat D, McGillivray BC, Diamant S, Wittmann BK, Sandor GG
Left ventricular systolic and diastolic function after two-stage anatomic correction of transposition of the great arteries.
Sandor GS, Freedom RM, Williams WG, LeBlanc J, Trusler G, Patterson MW, Ashmore PG
Pulmonary artery banding: results and current indications in pediatric cardiac surgery.
LeBlanc JG, Ashmore PG, Pineda E, Sandor GG, Patterson MW, Tipple M
Left ventricular systolic and diastolic function after total correction of tetralogy of Fallot.
Sandor GG, Patterson MW, Tipple M, Ashmore PG, Popov R
Effect of pressure loading, volume loading and surgery on left ventricular chamber and myocardial stiffness in congenital heart disease, with a reevaluation of normal pediatric values.
Sandor GG, Puterman ML, Patterson MW, Tipple MA, Vince DJ
Treatment of grafts and major vessel thrombosis with low-dose streptokinase in children.
LeBlanc JG, Culham JA, Chan KW, Patterson MW, Tipple M, Sandor GG
Fetal echocardiography: results in high-risk patients.
Sandor GG, Farquarson D, Wittmann B, Chow TC, Lau AE
Cardiovascular therapy in the newborn.
Clinical and echocardiographic evidence suggesting afterload reduction as a mechanism of action of tolazoline in neonatal hypoxemia.
Sandor GG, Macnab AJ, Akesode FA, Ebelt VJ, Pendray MR, Ling WY, Patterson MW, Tipple MA
Successful palliation by pulmonary artery banding in absent pulmonary valve syndrome with aneurysmal pulmonary arteries.
Opie JC, Sandor GG, Ashmore PG, Patterson MW
Serum digoxin levels in neonates under 1500 grams.
Sandor GG, Reid G, Patterson MW
Determination of left ventricular diastolic chamber stiffness and myocardial stiffness in patients with congenital heart disease.
Sandor GG, Olley PM
Serum digoxin levels in neonates whose weights are less than 1,500 grams.
Patterson MW, Reid G, Sandor GG
Intrinsic defects in the fetal alcohol syndrome: studies on 76 cases from British Columbia and the Yukon Territory.
Smith DF, Sandor GG, MacLeod PM, Tredwell S, Wood B, Newman DE
Long-term follow-up of patients after valvotomy for congenital valvular aortic stenosis in children: a clinical and actuarial follow-up.
Sandor GG, Olley PM, Trusler GA, Williams WG, Rowe RD, Morch JE
Noninvasive assessment of left ventricular function related to serum digoxin levels in neonates.
Sandor GG, Bloom KR, Izukawa T, Patterson MW, Rowe RD
Structure and function of the heart can be examined using ultrasound. My interest lies in using the latest ultrasound to characterize the heart’s ability to pump and to fill. This work attempts to accurately assess and diagnose abnormalities of function early, and to compare the results of different types of medical and surgical treatment to evaluate outcome. Our laboratory has been a pioneer in the simplification of non-invasive methods of assessing heart function and we have also developed a new technique to quantify the properties of the major blood vessels coming from the heart to see whether these are diseased or healthy. We are also examining the interaction of heart function with the properties of the blood vessels to see how efficient the heart and circulation are. These types of studies are of importance in patients who have some compromise of cardiac function, so that therapy may be optimised to enable the heart to work most efficiently.
Our laboratory has devised a technique whereby the heart can be imaged with ultrasound during exercise and with this technique are able to obtain indexes of cardiac function, cardiac output and examine the heart muscle contractility using stage exercise. This technique is unique and has been extremely useful in assessing the cardiac reserve in patients for whom decisions have to be made with regard to surgery, continuing potentially cardiotoxic medications and assessing the effects of these. This has been found very helpful in situations where the examination of the heart at rest has not provided enough information about the potential heart to do exercise. In addition, this technique has been very helpful in unmasking a partial blockage in blood vessels whereby exercise increased the cardiac output and has demonstrated a significant degree of obstruction that is not apparent in the resting state. We have undertaken some of this work for the Adult Congenital Heart Disease Program.
The antenatal diagnosis of congenital heart disease continues to develop and we have been one of the first centers to institute a fetal cardiac diagnosis program. This is unique in that it integrates perinatology and the fetal diagnosis program, which help in the management of these difficult situations. In addition to evaluating the accuracy of this technique, we have also examined issues of outcomes, population statistics and just as importantly, a qualitative study of such diagnoses. We have also started to use an adaptation of the technique of assessment of the vascular properties by ultrasound (alluded to in the previous paragraphs) to attempt to assess fetal circulatory health, and we hope that this test will give us further insights into placental insufficiency and perhaps an earlier diagnosis of such problems.