- Overview
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Newborn screening is designed to identify infants with treatable rare disorders at birth in order to start therapies before the infants get sick. These disorders can lead to developmental disability, growth failure, liver disease, seizures, and even death if untreated. The investigation of potential new candidate disorders for screening, evaluation of new screening tests or improvement of existing methods, and the measurement of the long-term effectiveness of screening to improve health are all active aspects of my research.
We have a focus on disorders affecting the use of fats as an energy source and a variant of one of these disorders that is common to coastal BC First Nations. This variant is associated with an increased risk of infant death, but may also have benefits related to traditional diets.. Investigation of this variant will lead to a better understanding of its clinical impact and help to identify effective interventions.
- Publications
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A simple method modification to increase separation of 2- and 3-hydroxyglutaric acid by GC-MS for clinical urine organic acids analysis.
Clinical biochemistry
Dubland JA and Sinclair G and Hilary D. Vallance and Bojana Rakic
DOI: 10.1016/j.clinbiochem.2022.04.016
PubMed: 35500672
04/2022Performance of Immunoglobulin G Serology on Finger Prick Capillary Dried Blood Spot Samples to Detect a SARS-CoV-2 Antibody Response.
Microbiology spectrum
Aidan Nikiforuk and McMillan B and Bartlett SR and Márquez AC and Pidduck T and Kustra J and David M. Goldfarb and Barakauskas V and Sinclair G and Patrick DM and Manish Sadarangani and Gina Ogilvie and Krajden M and Morshed M and Sekirov I and Jassem AN
DOI: 10.1128/spectrum.01405-21
PubMed: 35266818
03/2022Interference of ketone bodies on laboratory creatinine measurement in children with DKA: a call for change in testing practices.
Pediatric nephrology (Berlin, Germany)
Feldman-Kiss D and Li D and Cleve R and Sinclair G and Joshua Dubland and Li Wang
DOI: 10.1007/s00467-021-05324-0
PubMed: 34757480
11/2021Diagnostic yield from routine metabolic screening tests in evaluation of global developmental delay and intellectual disability
Paediatrics & Child Health
Hilary Vallance and Graham Sinclair and Bojana Rakic and Sylvia Stockler-Ipsiroglu
DOI: 10.1093/pch/pxaa112
09/2021Analysis of 2-methylcitric acid, methylmalonic acid, and total homocysteine in dried blood spots by LC-MS/MS for application in the newborn screening laboratory: A dual derivatization approach.
Journal of mass spectrometry and advances in the clinical lab
Joshua Dubland and Bojana Rakic and Hilary D. Vallance and Sinclair G
DOI: 10.1016/j.jmsacl.2021.03.001
PubMed: 34820666
03/2021Maternal vitamin B12 status in early pregnancy and its association with birth outcomes in Canadian mother-newborn Dyads.
The British journal of nutrition
Amy Tan and Sinclair G and Mattman A and Hilary D. Vallance and Yvonne Lamers
DOI: 10.1017/s0007114521000581
PubMed: 33602347
02/2021Investigating oxythiamine levels in children undergoing kidney transplantation and the risk of immediate post-operative metabolic and hemodynamic decompensation.
Pediatric nephrology (Berlin, Germany)
Golan O and Dyer R and Sinclair G and Blydt-Hansen T
DOI: 10.1007/s00467-020-04797-9
PubMed: 33067673
10/2020SETD1B-associated neurodevelopmental disorder.
Journal of medical genetics
Alexandra Roston and Evans D and Gill H and McKinnon M and Isidor B and Benjamin Cogné and Mwenifumbo J and van Karnebeek C and An J and Steven Jones and Farrer M and Demos M and Mary B. Connolly and William Gibson and CAUSES Study and EPGEN Study
DOI: 10.1136/jmedgenet-2019-106756
PubMed: 32546566
06/2020Performance of a Three-Tier (IRT-DNA-IRT) Cystic Fibrosis Screening Algorithm in British Columbia
International Journal of Neonatal Screening
DOI: 10.3390/ijns6020046
06/2020A Visit with Dr. Louis Woolf, Recognizing His 100th Birthday and His Contributions to the Diagnosis and Treatment of Phenylketonuria
International Journal of Neonatal Screening
DOI: 10.3390/ijns6020045
05/2020Vitamin B-12 Biomarkers Reviewed: Holotranscobalamin Allows Identification of Vitamin B12 Deficiency in Children with Short-Bowel Syndrome
Current developments in nutrition
St-Cyr C and Lamers Y and Casey L and Saunders M and Sinclair G and Mattman A
05/2020Clinical Impact and Cost Efficacy of Newborn Screening for Congenital Adrenal Hyperplasia
The Journal of Pediatrics
Danya A. Fox and Rebecca Ronsley and Asif R. Khowaja and Alon Haim and Hilary Vallance and Graham Sinclair and Shazhan Amed
DOI: 10.1016/j.jpeds.2019.12.057
05/2020Serum Betaine and Dimethylglycine Are Higher in South Asian Compared with European Pregnant Women in Canada, with Betaine and Total Homocysteine Inversely Associated in Early and Midpregnancy, Independent of Ethnicity
The Journal of Nutrition
Maria F Mujica-Coopman and Amy Tan and Theresa H Schroder and Graham Sinclair and Hilary D Vallance and Yvonne Lamers
DOI: 10.1093/jn/nxz178
12/2019The p.P479L variant in CPT1A is associated with infectious disease in a BC First Nation
Paediatrics & Child Health
Graham Sinclair and Sorcha Collins and Laura Arbour and Hilary Vallance
DOI: 10.1093/pch/pxy106
04/2019Atypical cerebral palsy: genomics analysis enables precision medicine
Genetics in Medicine
Matthews, A.M. and Blydt-Hansen, I. and Al-Jabri, B. and Andersen, J. and Tarailo-Graovac, M. and Price, M. and Selby, K. and Demos, M. and Connolly, M. and Drögemoller, B. and Shyr, C. and Mwenifumbo, J. and Elliott, A.M. and Lee, J. and Ghani, A. and Stöckler, S. and Salvarinova, R. and Vallance, H. and Sinclair, G. and Ross, C.J. and Wasserman, W.W. and McKinnon, M.L. and Horvath, G.A. and Goez, H. and van Karnebeek, C.D.
DOI: 10.1038/s41436-018-0376-y
2019Acute Shoshin beriberi syndrome immediately post–kidney transplant with rapid recovery after thiamine administration
Pediatric Transplantation
Elias, I.M. and Sinclair, G. and Blydt-Hansen, T.D.
DOI: 10.1111/petr.13493
2019Reference intervals for serum total vitamin B12 and holotranscobalamin concentrations and their change points with methylmalonic acid concentration to assess vitamin B12 status during early and mid-pregnancy
Clinical Chemistry and Laboratory Medicine
Schroder, T.H. and Tan, A. and Mattman, A. and Sinclair, G. and Barr, S.I. and Vallance, H.D. and Lamers, Y.
DOI: 10.1515/cclm-2018-1337
2019Pyruvate Carboxylase Deficiency Type C: A Rare Cause of Acute Transient Flaccid Paralysis with Ketoacidosis
Neuropediatrics
Almomen, M. and Sinclair, G. and Stockler-Ipsiroglu, S.G. and Horvath, G.A.
DOI: 10.1055/s-0038-1667171
2018Pregnant women of South Asian ethnicity in Canada have substantially lower vitamin B12 status compared with pregnant women of European ethnicity.
The British journal of nutrition
Schroder TH and Sinclair G and Mattman A and Jung B and Barr SI and Vallance HD and Lamers Y
DOI: 10.1017/s0007114517002331
PubMed: 28920568
09/2017De Novo Mutations in YWHAG Cause Early-Onset Epilepsy.
American journal of human genetics
Guella I and McKenzie MB and Evans DM and Buerki SE and Toyota EB and Van Allen MI and Epilepsy Genomics Study and Suri M and Elmslie F and Farrer MJ
DOI: 10.1016/j.ajhg.2017.07.004
PubMed: 28777935
08/2017Loss-of-Function and Gain-of-Function Mutations in KCNQ5 Cause Intellectual Disability or Epileptic Encephalopathy.
American journal of human genetics
Lehman A and Thouta S and Mancini GMS and Naidu S and van Slegtenhorst M and McWalter K and Person R and Mwenifumbo J and Salvarinova R and CAUSES Study and EPGEN Study and Guella I and Claydon T
DOI: 10.1016/j.ajhg.2017.05.016
PubMed: 28669405
07/2017A girl with developmental delay, ataxia, cranial nerve palsies, severe respiratory problems in infancy-Expanding NDST1 syndrome.
American journal of medical genetics. Part A
Armstrong L and Tarailo-Graovac M and Sinclair G and Seath KI and Wasserman WW and Ross CJ and van Karnebeek CD
DOI: 10.1002/ajmg.a.37621
PubMed: 28211985
03/2017Optic atrophy, cataracts, lipodystrophy/lipoatrophy, and peripheral neuropathy caused by a de novo OPA3 mutation.
Cold Spring Harbor molecular case studies
Bourne SC and Townsend KN and Shyr C and Matthews A and Lear SA and Attariwala R and Lehman A and Wasserman WW and van Karnebeek C and Sinclair G and Vallance H and Gibson WT
DOI: 10.1101/mcs.a001156
PubMed: 28050599
01/2017Pregnant women of South Asian ethnicity in Canada have substantially lower vitamin B12 status compared with pregnant women of European ethnicity
British Journal of Nutrition
Schroder, T.H. and Sinclair, G. and Mattman, A. and Jung, B. and Barr, S.I. and Vallance, H.D. and Lamers, Y.
DOI: 10.1017/S0007114517002331
2017A three-tier algorithm for guanidinoacetate methyltransferase (GAMT) deficiency newborn screening.
Sinclair GB and van Karnebeek CD and Ester M and Boyd F and Nelson T and Stockler-Ipsiroglu S and Vallance H
DOI: 10.1016/j.ymgme.2016.05.002
PubMed: 27233226
07/2016Integrated Multianalyte Second-Tier Testing for Newborn Screening for MSUD, IVA, and GAMT Deficiencies
Journal of Inborn Errors of Metabolism and Screening
DOI: 10.1177/2326409816666296
07/2016Exome Sequencing and the Management of Neurometabolic Disorders.
Tarailo-Graovac M and Shyr C and Ross CJ and Horvath GA and Salvarinova R and Ye XC and Zhang LH and Bhavsar AP and Lee JJ and Drögemöller BI and Abdelsayed M and Alfadhel M and Armstrong L and Baumgartner MR and Burda P and Connolly MB and Cameron J and Demos M and Dewan T and Dionne J
DOI: 10.1056/NEJMoa1515792
PubMed: 27276562
06/2016Reference interval of methylmalonic acid concentrations in dried blood spots of healthy, term newborns to facilitate neonatal screening of vitamin B12 deficiency.
Schroder TH and Mattman A and Sinclair G and Vallance HD and Lamers Y
DOI: 10.1016/j.clinbiochem.2016.03.007
PubMed: 27040901
03/2016Health economic evaluation of plasma oxysterol screening in the diagnosis of Niemann-Pick Type C disease among intellectually disabled using discrete event simulation.
van Karnebeek CD and Mohammadi T and Tsao N and Sinclair G and Sirrs S and Stockler S and Marra C
DOI: 10.1016/j.ymgme.2014.07.004
PubMed: 25095726
02/2015Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms.
Sirrs S and van Karnebeek CD and Peng X and Shyr C and Tarailo-Graovac M and Mandal R and Testa D and Dubin D and Carbonetti G and Glynn SE and Sayson B and Robinson WP and Han B and Wishart D and Ross CJ and Wasserman WW and Hurwitz TA and Sinclair G and Kaczocha M
DOI: 10.1186/s13023-015-0248-3
PubMed: 25885783
2015The genotypic and phenotypic spectrum of PIGA deficiency
Orphanet Journal of Rare Diseases
Tarailo-Graovac, M. and Sinclair, G. and Stockler-Ipsiroglu, S. and Van Allen, M. and Rozmus, J. and Shyr, C. and Biancheri, R. and Oh, T. and Sayson, B. and Lafek, M. and Ross, C.J. and Robinson, W.P. and Wasserman, W.W. and Rossi, A. and Van Karnebeek, C.D.M.
DOI: 10.1186/s13023-015-0243-8
2015AIMP1 deficiency presents as a cortical neurodegenerative disease with infantile onset.
Armstrong L and Biancheri R and Shyr C and Rossi A and Sinclair G and Ross CJ and Tarailo-Graovac M and Wasserman WW and van Karnebeek CD
DOI: 10.1007/s10048-014-0411-3
PubMed: 24958424
08/2014Mitochondrial carbonic anhydrase VA deficiency resulting from CA5A alterations presents with hyperammonemia in early childhood.
van Karnebeek CD and Sly WS and Ross CJ and Salvarinova R and Yaplito-Lee J and Santra S and Shyr C and Horvath GA and Eydoux P and Lehman AM and Bernard V and Newlove T and Ukpeh H and Chakrapani A and Preece MA and Ball S and Pitt J and Vallance HD and Coulter-Mackie M and Nguyen H
DOI: 10.1016/j.ajhg.2014.01.006
PubMed: 24530203
03/2014Performance of serum and dried blood spot acylcarnitine profiles for detection of fatty acid ß-oxidation disorders in adult patients with rhabdomyolysis.
Al-Thihli K and Sinclair G and Sirrs S and Mezei M and Nelson J and Vallance H
DOI: 10.1007/s10545-012-9578-7
PubMed: 23296367
03/2014Detection of a novel intragenic rearrangement in the creatine transporter gene by next generation sequencing.
Yu H and van Karnebeek C and Sinclair G and Hill A and Cui H and Zhang VW and Wong LJ
DOI: 10.1016/j.ymgme.2013.09.018
PubMed: 24140398
12/2013Acylcarnitine profile in thyroid disease.
Wong S and Hannah-Shmouni F and Sinclair G and Sirrs S and Dahl M and Mattman A
DOI: 10.1016/j.clinbiochem.2012.10.006
PubMed: 23089106
01/2013Carnitine palmitoyltransferase I and sudden unexpected infant death in British Columbia First Nations.
Sinclair GB and Collins S and Popescu O and McFadden D and Arbour L and Vallance HD
DOI: 10.1542/peds.2011-2924
PubMed: 23090344
11/2012Lysine restricted diet for pyridoxine-dependent epilepsy: first evidence and future trials.
van Karnebeek CD and Hartmann H and Jaggumantri S and Bok LA and Cheng B and Connolly M and Coughlin CR 2nd and Das AM and Gospe SM Jr and Jakobs C and van der Lee JH and Mercimek-Mahmutoglu S and Meyer U and Struys E and Sinclair G and Van Hove J and Collet JP and Plecko BR and Stockler S
DOI: 10.1016/j.ymgme.2012.09.006
PubMed: 23022070
11/2012Guanidinoacetate methyltransferase deficiency: first steps to newborn screening for a treatable neurometabolic disease.
Mercimek-Mahmutoglu S and Sinclair G and van Dooren SJ and Kanhai W and Ashcraft P and Michel OJ and Nelson J and Betsalel OT and Sweetman L and Jakobs C and Salomons GS
DOI: 10.1016/j.ymgme.2012.07.022
PubMed: 23031365
11/2012Enhanced interpretation of newborn screening results without analyte cutoff values.
Marquardt G and Currier R and McHugh DM and Gavrilov D and Magera MJ and Matern D and Oglesbee D and Raymond K and Rinaldo P and Smith EH and Tortorelli S and Turgeon CT and Lorey F and Wilcken B and Wiley V and Greed LC and Lewis B and Boemer F and Schoos R and Marie S
DOI: 10.1038/gim.2012.2
PubMed: 22766634
07/2012The use of parenteral nutrition for the management of PKU patient undergoing chemotherapy for lymphoma: a case report.
Salvarinova-Zivkovic R and Hartnett C and Sinclair G and Dix D and Horvath G and Lillquist Y and Stockler-Ipsiroglu S
DOI: 10.1016/j.ymgme.2012.01.007
PubMed: 22305856
04/2012Evaluation of two year treatment outcome and limited impact of arginine restriction in a patient with GAMT deficiency.
Mercimek-Mahmutoglu S and Dunbar M and Friesen A and Garret S and Hartnett C and Huh L and Sinclair G and Stockler S and Wellington S and Pouwels PJ and Salomons GS and Jakobs C
DOI: 10.1016/j.ymgme.2011.09.037
PubMed: 22019491
01/2012Glycine cleavage enzyme complex: molecular cloning and expression of the H-protein cDNA from cultured human skin fibroblasts.
Zay A and Choy FY and Patrick C and Sinclair G
DOI: 10.1139/O10-156
PubMed: 21539457
06/2011Protective effects of d-3-hydroxybutyrate and propionate during hypoglycemic coma: clinical and biochemical insights from infant rats.
Schutz PW and Struys EA and Sinclair G and Stockler S
DOI: 10.1016/j.ymgme.2011.02.015
PubMed: 21439874
06/2011Fish odour syndrome.
Li M and Al-Sarraf A and Sinclair G and Frohlich J
DOI: 10.1503/cmaj.100642
PubMed: 21422137
05/2011Infantile cardioencephalopathy due to a COX15 gene defect: report and review.
Alfadhel M and Lillquist YP and Waters PJ and Sinclair G and Struys E and McFadden D and Hendson G and Hyams L and Shoffner J and Vallance HD
DOI: 10.1002/ajmg.a.33881
PubMed: 21412973
04/2011Clinical validation of cutoff target ranges in newborn screening of metabolic disorders by tandem mass spectrometry: a worldwide collaborative project.
McHugh D and Cameron CA and Abdenur JE and Abdulrahman M and Adair O and Al Nuaimi SA and Åhlman H and Allen JJ and Antonozzi I and Archer S and Au S and Auray-Blais C and Baker M and Bamforth F and Beckmann K and Pino GB and Berberich SL and Binard R and Boemer F and Bonham J
DOI: 10.1097/GIM.0b013e31820d5e67
PubMed: 21325949
03/2011Diagnosis and management of patients with mitochondrial disease
British Columbia Medical Journal
Mattman, A. and O'Riley, M. and Waters, P.J. and Sinclair, G. and Mezei, M.M. and Clark, L. and Hendson, G. and Vallance, H. and Sirrs, S.
2011Glycine cleavage enzyme complex: Molecular cloning and expression of the H-protein cDNA from cultured human skin fibroblasts
Biochemistry and Cell Biology
Zay, A. and Choy, F.Y.M. and Patrick, C. and Sinclair, G.
DOI: 10.1139/o10-156
2011Treatment of intractable epilepsy in a female with SLC6A8 deficiency.
Mercimek-Mahmutoglu S and Connolly MB and Poskitt KJ and Horvath GA and Lowry N and Salomons GS and Casey B and Sinclair G and Davis C and Jakobs C and Stockler-Ipsiroglu S
DOI: 10.1016/j.ymgme.2010.08.016
PubMed: 20846889
12/2010Carnitine palmitoyltransferase 1A (CPT1A) P479L prevalence in live newborns in Yukon, Northwest Territories, and Nunavut.
Collins SA and Sinclair G and McIntosh S and Bamforth F and Thompson R and Sobol I and Osborne G and Corriveau A and Santos M and Hanley B and Greenberg CR and Vallance H and Arbour L
DOI: 10.1016/j.ymgme.2010.07.013
PubMed: 20696606
2010The paradox of the carnitine palmitoyltransferase type Ia P479L variant in Canadian Aboriginal populations.
Greenberg CR and Dilling LA and Thompson GR and Seargeant LE and Haworth JC and Phillips S and Chan A and Vallance HD and Waters PJ and Sinclair G and Lillquist Y and Wanders RJ and Olpin SE
DOI: 10.1016/j.ymgme.2008.12.018
PubMed: 19217814
04/2009Heparin cofactor II-thrombin complex: a biomarker of MPS disease.
Randall DR and Colobong KE and Hemmelgarn H and Sinclair GB and Hetty E and Thomas A and Bodamer OA and Volkmar B and Fernhoff PM and Casey R and Chan AK and Mitchell G and Stockler S and Melancon S and Rupar T and Clarke LA
DOI: 10.1016/j.ymgme.2008.05.001
PubMed: 18511319
08/2008Generation of a conditional knockout of murine glucocerebrosidase: utility for the study of Gaucher disease.
Sinclair GB and Jevon G and Colobong KE and Randall DR and Choy FY and Clarke LA
DOI: 10.1016/j.ymgme.2006.09.008
PubMed: 17079175
02/2007Heparin cofactor II-thrombin complex in MPS I: a biomarker of MPS disease.
Randall DR and Sinclair GB and Colobong KE and Hetty E and Clarke LA
DOI: 10.1016/j.ymgme.2006.01.005
PubMed: 16497528
07/2006Secretion of human glucocerebrosidase from stable transformed insect cells using native signal sequences.
Sinclair G and Pfeifer TA and Grigliatti TA and Choy FY
DOI: 10.1139/o05-165
PubMed: 16609695
04/2006Synonymous codon usage bias and the expression of human glucocerebrosidase in the methylotrophic yeast, Pichia pastoris.
Sinclair G and Choy FY
DOI: 10.1016/S1046-5928(02)00526-0
PubMed: 12356476
10/2002Heterologous expression and characterization of a rare Gaucher disease mutation (c.481C > T) from a Canadian aboriginal population using archival tissue samples.
Sinclair G and Choy FY and Ferreira P
DOI: 10.1006/mgme.2001.3215
PubMed: 11708865
11/2001A novel complex allele and two new point mutations in type 2 (acute neuronopathic) Gaucher disease.
Sinclair G and Choy FY and Humphries L
DOI: 10.1006/bcmd.1998.0210
PubMed: 9851895
12/1998 - Research
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Second-Tier Testing for Newborn Screening
The performance of newborn screening programs can be defined by the positive predictive value (PPV) of the screening tests, a major component of which is the false positive rate. Traditional approaches to screening for some disorders have an unacceptable false positive rate, but attempts to minimize this rate by raising screening cutoffs can lead to increased false negative rates and the associated devastating outcomes of a missed case. We have developed a number of second-tier screening tests, sampled from the same original newborn screening bloodspot, as an approach to reduce false positive rates without negatively affecting the sensitivity of testing. Our work involves the development of a number of mass spectrometry-based testing approaches and evaluation of the performance impacts of these tests in routine use. To date, we have implemented second-tier testing for congenital adrenal hyperplasia (CAH) and Maple Syrup Urine Disease (MSUD) and have methods in development for Propionic Acidemia (PA), Methylmalonic Acidemia (MMA), and Homocystinuria (HCY).GAMT Deficiency Screening
Guanidinoacetate methyltransferase (GAMT) deficiency is an inherited disorder of creatine biosynthesis that leads to severe neurological complications in affected children. Treatment with supplemental creatine and other dietary restrictions has been shown to be effective when initiated early. This makes GAMT deficiency a potential candidate for newborn screening. We are investigating the carrier frequency for GAMT deficiency in BC to determine a theoretical disease incidence and evaluating the measurement of guanidinoacetate (GAA) in bloodspots as a potential approach to population-wide newborn screening for this treatable disorder.CPT1a P479L Variant
The carnitine palmitoyltransferase 1A (CPT1a) p.P479L variant has recently been found to be common in coastal First Nations communities in BC and also in aboriginal populations in Alaska, NWT, Nunavut, and Greenland. CPT1a is a central enzyme in fatty acid oxidation and is required for import of fatty acids into the mitochondrion to be utilized as an energy source. This variant (p.P479L) was first identified in individuals with symptoms suggestive of a fatty acid oxidation disorder and has been shown to decrease CPT1a activity in vitro. We have performed a population based retrospective study in BC to confirm that the variant is common to coastal communities and is associated with a small increased risk in sudden unexpected death in infancy. Similar results have been found in Nunavut and Alaska. There is evidence, however, that this variant is also associated with improved plasma lipid profiles and obesity markers in adults suggesting a selective advantage, possibly related to alterations in the regulation of enzyme activity. We are continuing to investigate both the potential harms and benefits of this variant through prospective studies with community participants and basic biochemical investigations using in vitro methods to better understand the biochemical and clinical implications of this common variant.GrantsBC Children's Hospital Telethon Competition; Determination of the incidence and natural history of carnitine palmitoyltransferase I deficiency in BC First Nations; COMP; $22,000CDN; Principal Investigator
Hilary Vallance; Coinvestigators
Graham Sinclair, Laura Arbour.
BC Children's Hospital Telethon Competition
Development of methods for screening X-linked creatine transporter deficiency (X-CRTRD) in mental retardation.; COMP; $9,910 CDN; Principal Investigator
Sylvia Stockler; Coinvestigators
Hilary Vallance, Graham Sinclair.
Honours & Awards2004 Garrod Association Biochemical Genetics Fellowship; $25,000CDN
2004 Bluma Tischler Postdoctoral Fellowship; $22,500CDN
Research Group MembersMichelle Dittrick, Clinical Research Program Manager
Research Roundup: December 2021
This month’s Research Roundup covers a newly defined type of anxiety in parents of children with allergies, the best method for measuring serum creatinine in kids hospitalized with diabetic ketoacidosis, and the development of a new provincial pediatric diabetes registry.
