Overview

My research is focused on children who have lost a significant amount of their intestine or whose intestines do not function properly. Often these children have difficulty gaining weight and reaching their growth potential. I am interested in determining how changes to the community gut bacteria in these children can impact their growth and metabolism. Ultimately, I want to find treatments to restore a healthy balance of gut bacteria in these children in order to improve intestinal function, overall nutrition, and growth. I am also interested in determining how changes to the gut bacteria impact the body's immune system and overall level of inflammation potentially predisposing children with intestinal failure to infection, liver disease, and blood clots.

Publications

Pediatric breast masses: an argument for observation
Journal of Surgical Research
Cory M. McLaughlin, Jessica Gonzalez-Hernandez, Monica Bennett, Hannah G. Piper
DOI: 10.1016/j.jss.2018.03.056
08/2018

Access to paid parental leave for academic surgeons
Journal of Surgical Research
Dina S. Itum, Sarah C. Oltmann, Michael A. Choti, Hannah G. Piper
DOI: 10.1016/j.jss.2018.01.001
02/2018

A comparison of lipid minimization strategies in children with intestinal failure
Journal of Pediatric Surgery
Jessica Gonzalez-Hernandez, Purvi Prajapati, Gerald Ogola, Van Nguyen, Nandini Channabasappa, Hannah G Piper
DOI: 10.1016/j.jpedsurg.2017.10.030
10/2017

Growth Trajectory in Children With Short Bowel Syndrome During the First Two Years of Life
Journal of Pediatric Gastroenterology and Nutrition
Cory M. McLaughlin, Nandini Channabasappa, Jesse Pace, Hoa Nguyen, Hannah G. Piper
DOI: 10.1097/mpg.0000000000001762
09/2017

Predicting time to full enteral nutrition in children after significant bowel resection
Journal of Pediatric Surgery
Jessica Gonzalez-Hernandez, Purvi Prajapati, Gerald Ogola, Nandini Channabasappa, Barbara Drews, Hannah G. Piper
DOI: 10.1016/j.jpedsurg.2017.01.038
05/2017

A comparison of Broviac ® and peripherally inserted central catheters in children with intestinal failure
Journal of Pediatric Surgery
Carolina Blotte, Jennifer Styers, Hong Zhu, Nandini Channabasappa, Hannah G. Piper
DOI: 10.1016/j.jpedsurg.2017.01.036
05/2017

Caregiver Education Reduces the Incidence of Community-Acquired CLABSIs in the Pediatric Patient With Intestinal Failure
Gastroenterology Nursing
Barbie Drews, Michelle Macaluso, Hannah Piper, Nandini Channabasappa
DOI: 10.1097/sga.0000000000000274
2017

Severe Gut Microbiota Dysbiosis Is Associated With Poor Growth in Patients With Short Bowel Syndrome
Journal of Parenteral and Enteral Nutrition
Hannah G. Piper, Di Fan, Laura A. Coughlin, Evi X. Ho, Margaret M. McDaniel, Nandini Channabasappa, Jiwoong Kim, Minsoo Kim, Xiaowei Zhan, Yang Xie, Andrew Y. Koh
DOI: 10.1177/0148607116658762
07/2016

Central venous thrombosis in children with intestinal failure on long-term parenteral nutrition
Journal of Pediatric Surgery
Jessica Gonzalez-Hernandez, Yahya Daoud, Jennifer Styers, Janna M. Journeycake, Nandini Channabasappa, Hannah G. Piper
DOI: 10.1016/j.jpedsurg.2016.02.024
05/2016

Endoscopic button gastrostomy: Comparing a sutured endoscopic approach to the current techniques
Journal of Pediatric Surgery
Jessica Gonzalez-Hernandez, Yahya Daoud, Anne C. Fischer, Bradley Barth, Hannah G. Piper
DOI: 10.1016/j.jpedsurg.2015.10.014
01/2016

Recent Advances in the Management of Pediatric Short Bowel Syndrome: An Integrative Review of the Literature
Current Surgery Reports
Melody R. Saeman, Hannah G. Piper
DOI: 10.1007/s40137-015-0126-x
01/2016

Intestinal Neuronal Dysplasia-Like Submucosal Ganglion Cell Hyperplasia at the Proximal Margins of Hirschsprung Disease Resections
Pediatric and Developmental Pathology
Maya Swaminathan, Assaf P. Oron, Sumantra Chatterjee, Hannah Piper, Sandy Cope-Yokoyama, Aravinda Chakravarti, Raj P. Kapur
DOI: 10.2350/15-07-1675-oa.1
11/2015

Use of Ethanol Lock Therapy for Children with Intestinal Failure on Long-Term Parenteral Nutrition
Diet and Nutrition in Critical Care
Hannah G. Piper, Paul W. Wales
DOI: 10.1007/978-1-4614-8503-2_15-1
2014

NOTES suction grasper for tubular viscera - characterization of gripping force when varying hole size, diameter, and number
2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Robert J. Brooks, Hannah Piper, Thomas Looi, James Drake
DOI: 10.1109/embc.2013.6610603
07/2013

Peripherally Inserted Central Catheters for Long-term Parenteral Nutrition in Infants With Intestinal Failure
Journal of Pediatric Gastroenterology and Nutrition
Hannah G. Piper, Nicole T. de Silva, Joao G. Amaral, Yaron Avitzur, Paul W. Wales
DOI: 10.1097/mpg.0b013e3182801e7b
05/2013

Delayed primary serial transverse enteroplasty as a novel management strategy for infants with congenital ultra-short bowel syndrome
Journal of Pediatric Surgery
Paul W. Wales, Tim Jancelewicz, Rodrigo L. Romao, Hannah G. Piper, Nicole T. de Silva, Yaron Avitzur
DOI: 10.1016/j.jpedsurg.2013.02.015
05/2013

Prevention of catheter-related blood stream infections in children with intestinal failure
Current Opinion in Gastroenterology
Hannah G. Piper, Paul W. Wales
DOI: 10.1097/mog.0b013e328358e268
01/2013

Ovarian torsion: diagnosis of inclusion mandates earlier intervention
Journal of Pediatric Surgery
Hannah G. Piper, Sarah C. Oltmann, Lin Xu, Sri Adusumilli, Anne C. Fischer
DOI: 10.1016/j.jpedsurg.2012.06.011
11/2012

Single-incision laparoscopic surgery in children: a randomized control trial of acute appendicitis
Surgical Endoscopy
Eduardo A. Perez, Hannah Piper, Lorrie S. Burkhalter, Anne C. Fischer
DOI: 10.1007/s00464-012-2617-5
2012

Childhood Diseases of the Thyroid and Parathyroid Glands
Pediatric Surgery
Hannah G. Piper, Michael A. Skinner
DOI: 10.1016/b978-0-323-07255-7.00058-1
2012

Gracilis transposition flap for repair of an acquired rectovaginal fistula in a pediatric patient
Journal of Pediatric Surgery
Hannah G. Piper, Andrew Trussler, David Schindel
DOI: 10.1016/j.jpedsurg.2011.05.004
08/2011

Is it necessary to drain all postoperative fluid collections after appendectomy for perforated appendicitis?
Journal of Pediatric Surgery
Hannah G. Piper, Betul Derinkuyu, Korgun Koral, Eduardo A. Perez, Joseph T. Murphy
DOI: 10.1016/j.jpedsurg.2011.03.043
06/2011

Detection and Management of Hypothyroidism Following Thyroid Lobectomy: Evaluation of a Clinical Algorithm
Annals of Surgical Oncology
Amanda Johner, Obi L. Griffith, Blair Walker, Leanne Wood, Hannah Piper, Graeme Wilkins, Christopher Baliski, Steven J. M. Jones, Sam M. Wiseman
DOI: 10.1245/s10434-011-1627-1
03/2011

Use of a Continuous Glucose Sensor in an Extracorporeal Life Support Circuit
Journal of Diabetes Science and Technology
Garry M. Steil, Jamin Alexander, Alexandra Papas, Monica Langer, Biren P. Modi, Hannah Piper, Tom Jaksic, Rebecca Gottlieb, Michael S. D. Agus
DOI: 10.1177/193229681100500113
01/2011

Intestinal atresias: factors affecting clinical outcomes
Journal of Pediatric Surgery
Hannah G. Piper, Julia Alesbury, Stephen D. Waterford, David Zurakowski, Tom Jaksic
DOI: 10.1016/j.jpedsurg.2007.09.053
07/2008

Current management of appendicitis at a community center—how can we improve?
The American Journal of Surgery
Hannah G. Piper, Conrad Rusnak, William Orrom, Allen Hayashi, Johann Cunningham
DOI: 10.1016/j.amjsurg.2007.12.033
05/2008

First Report of the International Serial Transverse Enteroplasty Data Registry: Indications, Efficacy, and Complications
Journal of the American College of Surgeons
Biren P. Modi, Patrick J. Javid, Tom Jaksic, Hannah Piper, Monica Langer, Christopher Duggan, Daniel Kamin, Heung Bae Kim
DOI: 10.1016/j.jamcollsurg.2006.12.033
03/2007

Nutrition and Wound Healing at the Age Extremes
Nutrition and Wound Healing
Hannah Piper, Tom Jaksic, Patrick Javid
DOI: 10.1201/9780203500231.ch13
10/2006

Growth and Nutritional Status in Infants With Short-Bowel Syndrome After the Serial Transverse Enteroplasty Procedure
Clinical Gastroenterology and Hepatology
Christopher Duggan, Hannah Piper, Patrick J. Javid, Clarissa Valim, Sharon Collier, Heung Bae Kim, Tom Jaksic
DOI: 10.1016/j.cgh.2006.06.006
10/2006

Real-Time Continuous Glucose Monitoring in Pediatric Patients During and After Cardiac Surgery
PEDIATRICS
H. G. Piper, J. L. Alexander, A. Shukla, F. Pigula, J. M. Costello, P. C. Laussen, T. Jaksic, M. S.D. Agus
DOI: 10.1542/peds.2006-0347
09/2006

The impact of prenatal bowel dilation on clinical outcomes in neonates with gastroschisis
Journal of Pediatric Surgery
Hannah G. Piper, Tom Jaksic
DOI: 10.1016/j.jpedsurg.2006.01.005
05/2006

The Effect of Insulin Infusion Upon Protein Metabolism in Neonates on Extracorporeal Life Support
Transactions of the ... Meeting of the American Surgical Association
Michael S. D. Agus, Patrick J. Javid, Hannah G. Piper, David Wypij, Christopher P. Duggan, Daniel P. Ryan, Tom Jaksic
DOI: 10.1097/01.sla.0000237758.93186.c8
2006

The second STEP: the feasibility of repeat serial transverse enteroplasty
Journal of Pediatric Surgery
Hannah Piper, Biren P. Modi, Heung Bae Kim, Dario Fauza, John Glickman, Tom Jaksic
DOI: 10.1016/j.jpedsurg.2006.08.015
2006

Detecting and defining hypothyroidism after hemithyroidectomy
The American Journal of Surgery
Hannah G. Piper, Samuel P. Bugis, Graeme E. Wilkins, Blair A.M. Walker, Sam Wiseman, Christopher R. Baliski
DOI: 10.1016/j.amjsurg.2005.01.038
05/2005

Burns, Trauma and Critical Care
Manual of Pediatric Nutrition, 4th edition
2005

Models for antigen receptor gene rearrangementMultiple rearrangement in the TCR: allelic exclusion or inclusion?
Journal of Immunology
PubMed: 10438912
1999

Research

Current Projects
I am currently conducting a study investigating the use of probiotics as a means to predictably alter the gut microbiota in children with intestinal failure and poor growth. It is unclear whether taking oral probiotics is an effective way to restore balance to the gut bacteria given that many of these patients have rapid intestinal transit and difficulty with absorption. Ultimately, if probiotics prove efficacious, a larger study can be performed to determine the type and duration of therapy that would be most effective.

I am also involved in a study looking at how the gut microbiota contribute to inflammation in the liver of children with intestinal failure who are dependent on intravenous nutrition (parenteral nutrition). It is well known that some children on prolonged parenteral nutrition develop significant hepatic cholestasis and inflammation but the exact etiology of this is not completely understood. Episodes of sepsis, prematurity, the lack of enteral nutrition, and certain components of the parenteral nutrition are all thought to contribute. Recently, there has been evidence to suggest that the intestinal microbiota may also contribute to hepatic inflammation. In this study, I am trying to correlate the abundance of certain species of intestinal bacteria with abnormal hepatic metabolism of propionate (a short chain fatty acid) in children with short bowel syndrome.

Another study I am participating in involves determining if children with short bowel syndrome are predisposed to central venous thrombosis. These children frequently require long-term parenteral nutrition necessitating a functional central venous catheter. Unfortunately, they seem to have an increased incidence of central venous thrombosis compared to other patient groups. A preliminary study that I conducted identified a high incidence of acquired thrombophilia in these children due likely to both systemic inflammation and underlying compromised liver function. I am currently studying the best way to prevent venous thrombosis in these patients including screening and potential anticoagulation.

Grants

"Targeted probiotic therapy to improve the gut microbiota and growth in children with short bowel syndrome"; ASPEN Rhoads Foundation Grant; 1/2017- 1/2018.

"Role of intestial microbiota in children with intestinal failure and bacterial overgrowth"; APSA Foundation Grant; 7/2014- 7/2015.

"The role of the intestinal microbiota in the development of cholestatic liver disease in infants with short bowel syndrome"; Discovery Fund Grant; 1/2016- 1/2017.

Honours & Awards

Gut Microbiota Dysbiosis is Associated with Poor Growth in Children with Show Bowel Syndrome; 2015- 2017.

Provider of the Month Award for the provider who best fulfills the hospital mission; Children's Medical Center, Dallas, Texas; 2016.

Poster with Distinction, International Pediatric Intestinal Failure and Rehabilitation Symposium; 2016.