Hannah Piper

MD

Investigator, BC Children's Hospital

My research is focused on children who have lost a significant amount of their intestine or whose intestines do not function properly. Often these children have difficulty gaining weight and reaching their growth potential. I am interested in determining how changes to the community gut bacteria in these children can impact their growth and metabolism. Ultimately, I want to find treatments to restore a healthy balance of gut bacteria in these children in order to improve intestinal function, overall nutrition, and growth. I am also interested in determining how changes to the gut bacteria impact the body's immune system and overall level of inflammation potentially predisposing children with intestinal failure to infection, liver disease, and blood clots.

Academic Affiliations

  • Associate Professor, Division of Pediatric Surgery, Department of Surgery, Faculty of Medicine, University of British Columbia
  • Research Theme: Healthy Starts
  • Research Group(s): Immunity in Health and Disease; Origins of Child Health and Disease

Contact Information

Location

4500 Oak St, Vancouver, BC, Canada, V6H 3N1

Crosstalk with infant-derived Th17 cells, as well as exposure to IL-22 promotes maturation of intestinal epithelial cells in an enteroid model

Frontiers in Immunology

Sharafian, Z. and Littlejohn, P.T. and Michalski, C. and Sousa, J.A. and Cheung, J. and Hill, M. and Piper, H. and Jacobson, K. and Lavoie, P.M. and Allaire, J.M. and Vallance, B.A.

DOI: 10.3389/fimmu.2025.1582688

Multiomics profiling and parenteral nutrition weaning in pediatric patients with intestinal failure: A longitudinal cohort study

Journal of Parenteral and Enteral Nutrition

Tappauf, N. and Lamers, Y. and Sham, H.P. and Piper, H.G.

DOI: 10.1002/jpen.2742

Health-Related Quality of Life in Pediatric Intestinal Failure from Infancy to Adolescence: An International, Multi-Center Evaluation

Journal of Pediatrics

Modi, B.P. and Piper, H.G. and Belza, C. and Staffa, S. and Arnold, M.A. and Boctor, D.L. and Channabasappa, N. and Cohran, V.C. and Galloway, D.P. and Sudan, D. and Wales, P.W. and Warner, B.W. and Murtadi, G. and Javid, P.J.

DOI: 10.1016/j.jpeds.2025.114566

Response from the Canadian Children Inflammatory Bowel Disease Network to the US Food and Drug Administration Draft Guidance for Industry on pediatric inflammatory bowel disease: developing drugs for treatment

Journal of the Canadian Association of Gastroenterology

Wine, E. and Debruyn, J. and Crowley, E. and Griffiths, A.M. and Jeong, J. and Jacobson, K. and Lawrence, S. and Piper, H. and Smyth, M. and Tropini, C. and Vallance, B. and de Bruyn, J. and Huynh, H. and Carroll, M. and Isaac, D.M. and Armstrong, H. and El-Matary, W. and Grover, Z. and Bax, K. and Brill, H. and Dowhaniuk, J. and Prowse, K. and Sherlock, M. and Zachos, M. and Hart, L. and Popalis, C. and Griffths, A.M. and Muise, A. and Ricciuto, A. and Benchimol, E. and Jones, N. and Carman, N. and Church, P. and Walters, T. and Mulder, D. and Mack, D. and Stanisz, J. and Stintzi, A. and Pai, N. and Deslandres, C. and Breton, J. and Grzywacz, K. and Jantchou, P. and Chapuy, L. and Schneider, R. and Otley, A. and Burnett, D. and Critch, J. and Dinn, S.

DOI: 10.1093/jcag/gwae034

The Effect of Nutrient Deprivation on Early Life Small Intestinal Mucosal Microbiome and Host Proteome

Journal of Nutrition

Bar-Yoseph, H. and Krekhno, Z. and Cirstea, M. and Holani, R. and Moon, K.-M. and Foster, L.J. and Wieck, M. and Piper, H.G. and Finlay, B.B.

DOI: 10.1016/j.tjnut.2023.12.020

Risk Factors for Infection in Neonates With Intestinal Failure

Journal of Pediatric Surgery

Wu, D. and Van Oerle, R. and Martinez, A. and Piper, H.G.

DOI: 10.1016/j.jpedsurg.2024.01.019

Intestinal microbial and metabolite profile in infants with small bowel stomas after bowel resection

Journal of Pediatric Gastroenterology and Nutrition

Piper, H.G. and Bording-Jorgensen, M. and Veniamin, S. and Zhang, Z. and Suarez, R.G. and Armstrong, H. and Silverman, J.A. and Wine, E.

DOI: 10.1002/jpn3.12327

Standardizing vitamin D supplementation to minimize deficiency in children with intestinal failure

Nutrition in Clinical Practice

Zhong, J. and Martins, D.S. and Piper, H.G.

DOI: 10.1002/ncp.11094

Treatment and Outcomes of Congenital Ovarian Cysts A Study by the Canadian Consortium for Research in Pediatric Surgery (CanCORPS)

Annals of Surgery

Safa, N. and Yanchar, N. and Puligandla, P. and Sewitch, M. and Baird, R. and Beaunoyer, M. and Campbell, N. and Chadha, R. and Griffiths, C. and Jones, S. and Kaur, M. and Le-Nguyen, A. and Nasr, A. and Pich, N. and Piper, H. and Prasil, P. and Romao, R.L.P. and Vanhouwelingen, L. and Wales, P. and Guadagno, E. and Emil, S.

DOI: 10.1097/SLA.0000000000005409

Hirschsprung-associated inflammatory bowel disease: A multicenter study from the APSA Hirschsprung disease interest group

Journal of Pediatric Surgery

Sutthatarn, P. and Lapidus-Krol, E. and Smith, C. and Halaweish, I. and Rialon, K. and Ralls, M.W. and Rentea, R.M. and Madonna, M.B. and Haddock, C. and Rocca, A.M. and Gosain, A. and Frischer, J. and Piper, H. and Goldstein, A.M. and Saadai, P. and Durham, M.M. and Dickie, B. and Jafri, M. and Langer, J.C.

DOI: 10.1016/j.jpedsurg.2023.01.018

Nutrition considerations in pediatric surgical patients

Nutrition in Clinical Practice

Debby S. Martins and Hannah G. Piper

DOI: 10.1002/ncp.10855

06 / 2022

The Importance of the ileocecal valve and colon in achieving intestinal independence in infants with short bowel syndrome

Journal of Pediatric Surgery

Peters, F.B. and Bone, J.N. and Van Oerle, R. and Albersheim, S. and Casey, L. and Piper, H.

DOI: 10.1016/j.jpedsurg.2021.09.028

Urine sodium to urine creatinine ratio as a marker of total body sodium in infants with intestinal failure

Journal of Pediatric Surgery

Choi, S. and Casey, L. and Albersheim, S. and Van Oerle, R. and Irvine, M.A. and Piper, H.G.

DOI: 10.1016/j.jpedsurg.2021.12.035

Differentiating congenital ovarian cysts from other abdominal cystic lesions in female infants: A study by the Canadian Consortium for Research in Pediatric Surgery (CanCORPS)

Journal of Pediatric Surgery

Safa, N. and Yanchar, N. and Puligandla, P. and Sewitch, M. and Baird, R. and Beaunoyer, M. and Butter, A. and Campbell, N. and Chadha, R. and Griffiths, C. and Jones, S. and Kaur, M. and Le-Nguyen, A. and Nasr, A. and Pich, N. and Piper, H. and Prasil, P. and Romao, R. and VanHouwelingen, L. and Wales, P. and Guadagno, E. and Emil, S. and for the Canadian Consortium for Research in Pediatric Surgery (CanCORPS)

DOI: 10.1016/j.jpedsurg.2021.12.043

NeoCHIRP: A model for intestinal rehabilitation in the neonatal intensive care unit

Nutrition in Clinical Practice

Linda M. Casey and Jaclyn Strauss and Keerat K. Dhaliwal and Sonia Butterworth and Hannah G. Piper and Susan G. Albersheim

DOI: 10.1002/ncp.10734

12 / 2021

Use of instructional videos to reduce central venous catheter complications in children with intestinal failure receiving home parenteral nutrition

Nutrition in Clinical Practice

August Pierik and Debby S. Martins and Linda Casey and Hannah G. Piper

DOI: 10.1002/ncp.10638

08 / 2021

The effect of daily probiotics on the incidence and severity of necrotizing enterocolitis in infants with very low birth weight

Canadian Journal of Surgery

Que, J. and Van Oerle, R. and Albersheim, S. and Panczuk, J. and Piper, H.

DOI: 10.1503/cjs.016920

Enteral Nutrition in Pediatric Short-Bowel Syndrome.

Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition

Channabasappa N and Girouard S and Nguyen V and Piper H

DOI: 10.1002/ncp.10565 PubMed: 32815247

08 / 2020

The Impact of Lactobacillus Probiotics on the Gut Microbiota in Children With Short Bowel Syndrome

Journal of Surgical Research

Piper, H.G. and Coughlin, L.A. and Hussain, S. and Nguyen, V. and Channabasappa, N. and Koh, A.Y.

DOI: 10.1016/j.jss.2020.01.024

A comparison of small bowel and fecal microbiota in children with short bowel syndrome

Journal of Pediatric Surgery

Piper, H.G. and Coughlin, L.A. and Nguyen, V. and Channabasappa, N. and Koh, A.Y.

DOI: 10.1016/j.jpedsurg.2020.01.032

A Comparison of Smoflipid and Intralipid in the Early Management of Infants with Intestinal Failure

Journal of Pediatric Surgery

Casson, C. and Nguyen, V. and Nayak, P. and Channabasappa, N. and Berris, K. and Panczuk, J. and Bhiladvala, C. and Dasgupta, T. and Piper, H.G.

DOI: 10.1016/j.jpedsurg.2019.09.073

Access to Paid Parental Leave for Academic Surgeons

Journal of Surgical Research

Itum, D.S. and Oltmann, S.C. and Choti, M.A. and Piper, H.G.

DOI: 10.1016/j.jss.2018.01.001

A large prenatally undiagnosed mass in a preterm infant, what could it be?

NeoReviews

Ibrahim, J. and Pavageau, L. and Miller, J. and Timmons, C.F. and Wickiser, J.E. and Piper, H. and Dariya, V. and Brion, L.P.

DOI: 10.1542/neo.19-7-e413

Intestinal microbiota in short bowel syndrome

Seminars in Pediatric Surgery

Piper, H.G.

DOI: 10.1053/j.sempedsurg.2018.07.007

Pediatric breast masses: an argument for observation

Journal of Surgical Research

McLaughlin, C.M. and Gonzalez-Hernandez, J. and Bennett, M. and Piper, H.G.

DOI: 10.1016/j.jss.2018.03.056

Growth Trajectory in Children with Short Bowel Syndrome during the First 2 Years of Life

Journal of Pediatric Gastroenterology and Nutrition

McLaughlin, C.M. and Channabasappa, N. and Pace, J. and Nguyen, H. and Piper, H.G.

DOI: 10.1097/MPG.0000000000001762

Anticoagulation results in increased line salvage for children with intestinal failure and central venous thrombosis

Journal of Pediatric Surgery

McLaughlin, C.M. and Bennett, M. and Channabasappa, N. and Journeycake, J. and Piper, H.G.

DOI: 10.1016/j.jpedsurg.2018.02.007

A comparison of lipid minimization strategies in children with intestinal failure

Journal of Pediatric Surgery

Gonzalez-Hernandez, J. and Prajapati, P. and Ogola, G. and Nguyen, V. and Channabasappa, N. and Piper, H.G.

DOI: 10.1016/j.jpedsurg.2017.10.030

Caregiver Education Reduces the Incidence of Community-Acquired CLABSIs in the Pediatric Patient with Intestinal Failure

Gastroenterology Nursing

Drews, B. and Macaluso, M. and Piper, H. and Channabasappa, N.

DOI: 10.1097/SGA.0000000000000274

A comparison of Broviac and peripherally inserted central catheters in children with intestinal failure

Journal of Pediatric Surgery

Blotte, C. and Styers, J. and Zhu, H. and Channabasappa, N. and Piper, H.G.

DOI: 10.1016/j.jpedsurg.2017.01.036

Severe Gut Microbiota Dysbiosis Is Associated with Poor Growth in Patients with Short Bowel Syndrome

Journal of Parenteral and Enteral Nutrition

Piper, H.G. and Fan, D. and Coughlin, L.A. and Ho, E.X. and McDaniel, M.M. and Channabasappa, N. and Kim, J. and Kim, M. and Zhan, X. and Xie, Y. and Koh, A.Y.

DOI: 10.1177/0148607116658762

Predicting time to full enteral nutrition in children after significant bowel resection

Journal of Pediatric Surgery

Gonzalez-Hernandez, J. and Prajapati, P. and Ogola, G. and Channabasappa, N. and Drews, B. and Piper, H.G.

DOI: 10.1016/j.jpedsurg.2017.01.038

Endoscopic button gastrostomy: Comparing a sutured endoscopic approach to the current techniques

Journal of Pediatric Surgery

Gonzalez-Hernandez, J. and Daoud, Y. and Fischer, A.C. and Barth, B. and Piper, H.G.

DOI: 10.1016/j.jpedsurg.2015.10.014

Recent advances in the management of pediatric short bowel syndrome: An integrative review of the literature

Current Surgery Reports

Saeman, M.R. and Piper, H.G.

DOI: 10.1007/s40137-015-0126-x

Central venous thrombosis in children with intestinal failure on long-term parenteral nutrition

Journal of Pediatric Surgery

Gonzalez-Hernandez, J. and Daoud, Y. and Styers, J. and Journeycake, J.M. and Channabasappa, N. and Piper, H.G.

DOI: 10.1016/j.jpedsurg.2016.02.024

Intestinal neuronal dysplasia-like submucosal ganglion cell hyperplasia at the proximal margins of hirschsprung disease resections

Pediatric and Developmental Pathology

Swaminathan, M. and Oron, A.P. and Chatterjee, S. and Piper, H. and Cope-Yokoyama, S. and Chakravarti, A. and Kapur, R.P.

DOI: 10.2350/15-07-1675-OA.1

Use of ethanol lock therapy for children with intestinal failure on long-term parenteral nutrition

Diet and Nutrition in Critical Care

Piper, H.G. and Wales, P.W.

DOI: 10.1007/978-1-4614-7836-2_133

Delayed primary serial transverse enteroplasty as a novel management strategy for infants with congenital ultra-short bowel syndrome

Journal of Pediatric Surgery

Wales, P.W. and Jancelewicz, T. and Romao, R.L. and Piper, H.G. and De Silva, N.T. and Avitzur, Y.

DOI: 10.1016/j.jpedsurg.2013.02.015

Prevention of catheter-related blood stream infections in children with intestinal failure

Current Opinion in Gastroenterology

Piper, H.G. and Wales, P.W.

DOI: 10.1097/MOG.0b013e328358e268

Single-incision laparoscopic surgery in children: A randomized control trial of acute appendicitis

Surgical Endoscopy

Perez, E.A. and Piper, H. and Burkhalter, L.S. and Fischer, A.C.

DOI: 10.1007/s00464-012-2617-5

NOTES suction grasper for tubular viscera - Characterization of gripping force when varying hole size, diameter, and number

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

Brooks, R.J. and Piper, H. and Looi, T. and Drake, J.

DOI: 10.1109/EMBC.2013.6610603

Peripherally inserted central catheters for long-term parenteral nutrition in infants with intestinal failure

Journal of Pediatric Gastroenterology and Nutrition

Piper, H.G. and De Silva, N.T. and Amaral, J.G. and Avitzur, Y. and Wales, P.W.

DOI: 10.1097/MPG.0b013e3182801e7b

Childhood Diseases of the Thyroid and Parathyroid Glands

Pediatric Surgery

Piper, H.G. and Skinner, M.A.

DOI: 10.1016/B978-0-323-07255-7.00058-1

Ovarian torsion: Diagnosis of inclusion mandates earlier intervention

Journal of Pediatric Surgery

Piper, H.G. and Oltmann, S.C. and Xu, L. and Adusumilli, S. and Fischer, A.C.

DOI: 10.1016/j.jpedsurg.2012.06.011

Use of a continuous glucose sensor in an extracorporeal life support circuit

Journal of Diabetes Science and Technology

Steil, G.M. and Alexander, J. and Papas, A. and Langer, M. and Modi, B.P. and Piper, H. and Jaksic, T. and Gottlieb, R. and Agus, M.S.D.

DOI: 10.1177/193229681100500113

Gracilis transposition flap for repair of an acquired rectovaginal fistula in a pediatric patient

Journal of Pediatric Surgery

Piper, H.G. and Trussler, A. and Schindel, D.

DOI: 10.1016/j.jpedsurg.2011.05.004

Is it necessary to drain all postoperative fluid collections after appendectomy for perforated appendicitis?

Journal of Pediatric Surgery

Piper, H.G. and Derinkuyu, B. and Koral, K. and Perez, E.A. and Murphy, J.T.

DOI: 10.1016/j.jpedsurg.2011.03.043

Detection and management of hypothyroidism following thyroid lobectomy: Evaluation of a clinical algorithm

Annals of Surgical Oncology

Johner, A. and Griffith, O.L. and Walker, B. and Wood, L. and Piper, H. and Wilkins, G. and Baliski, C. and Jones, S.J.M. and Wiseman, S.M.

DOI: 10.1245/s10434-011-1627-1

Intestinal atresias: factors affecting clinical outcomes

Journal of Pediatric Surgery

Piper, H.G. and Alesbury, J. and Waterford, S.D. and Zurakowski, D. and Jaksic, T.

DOI: 10.1016/j.jpedsurg.2007.09.053

Current management of appendicitis at a community center-how can we improve?

American Journal of Surgery

Piper, H.G. and Rusnak, C. and Orrom, W. and Hayashi, A. and Cunningham, J.

DOI: 10.1016/j.amjsurg.2007.12.033

First Report of the International Serial Transverse Enteroplasty Data Registry: Indications, Efficacy, and Complications

Journal of the American College of Surgeons

Modi, B.P. and Javid, P.J. and Jaksic, T. and Piper, H. and Langer, M. and Duggan, C. and Kamin, D. and Kim, H.B.

DOI: 10.1016/j.jamcollsurg.2006.12.033

Nutrition and Wound Healing at the Age Extremes

Nutrition and Wound Healing

Hannah Piper and Tom Jaksic and Patrick Javid

DOI: 10.1201/9780203500231-18

10 / 2006

Growth and Nutritional Status in Infants With Short-Bowel Syndrome After the Serial Transverse Enteroplasty Procedure

Clinical Gastroenterology and Hepatology

Duggan, C. and Piper, H. and Javid, P.J. and Valim, C. and Collier, S. and Kim, H.B. and Jaksic, T.

DOI: 10.1016/j.cgh.2006.06.006

The second STEP: the feasibility of repeat serial transverse enteroplasty

Journal of Pediatric Surgery

Piper, H. and Modi, B.P. and Kim, H.B. and Fauza, D. and Glickman, J. and Jaksic, T.

DOI: 10.1016/j.jpedsurg.2006.08.015

Real-time continuous glucose monitoring in pediatric patients during and after cardiac surgery

Pediatrics

Piper, H.G. and Alexander, J.L. and Shukla, A. and Pigula, F. and Costello, J.M. and Laussen, P.C. and Jaksic, T. and Agus, M.S.D.

DOI: 10.1542/peds.2006-0347

The impact of prenatal bowel dilation on clinical outcomes in neonates with gastroschisis

Journal of Pediatric Surgery

Piper, H.G. and Jaksic, T.

DOI: 10.1016/j.jpedsurg.2006.01.005

The effect of insulin infusion upon protein metabolism in neonates on extracorporeal life support

Annals of Surgery

Agus, M.S.D. and Javid, P.J. and Piper, H.G. and Wypij, D. and Duggan, C.P. and Ryan, D.P. and Jaksic, T.

DOI: 10.1097/01.sla.0000237758.93186.c8

Burns, Trauma and Critical Care

Manual of Pediatric Nutrition, 4th edition

Piper HG, Jaksic T. Burns, Trauma and Critical Care. In: Hendricks KM, Duggan C, Walker WA, eds. Manual of Pediatric Nutrition. 4th edition. Hamilton: BC Decker Inc., 2005.

Detecting and defining hypothyroidism after hemithyroidectomy

American Journal of Surgery

Piper, H.G. and Bugis, S.P. and Wilkins, G.E. and Walker, B.A.M. and Wiseman, S. and Baliski, C.R. and Swartz, K.

DOI: 10.1016/j.amjsurg.2005.01.038

Models for antigen receptor gene rearrangement. II. Multiple rearrangement in the TCR: Allelic exclusion or inclusion?

Journal of Immunology

Piper, H. and Litwin, S. and Mehr, R.

Current Projects

I am currently conducting a study investigating the use of probiotics as a means to predictably alter the gut microbiota in children with intestinal failure and poor growth. It is unclear whether taking oral probiotics is an effective way to restore balance to the gut bacteria given that many of these patients have rapid intestinal transit and difficulty with absorption. Ultimately, if probiotics prove efficacious, a larger study can be performed to determine the type and duration of therapy that would be most effective.

I am also involved in a study looking at how the gut microbiota contribute to inflammation in the liver of children with intestinal failure who are dependent on intravenous nutrition (parenteral nutrition). It is well known that some children on prolonged parenteral nutrition develop significant hepatic cholestasis and inflammation but the exact etiology of this is not completely understood. Episodes of sepsis, prematurity, the lack of enteral nutrition, and certain components of the parenteral nutrition are all thought to contribute. Recently, there has been evidence to suggest that the intestinal microbiota may also contribute to hepatic inflammation. In this study, I am trying to correlate the abundance of certain species of intestinal bacteria with abnormal hepatic metabolism of propionate (a short chain fatty acid) in children with short bowel syndrome.

Another study I am participating in involves determining if children with short bowel syndrome are predisposed to central venous thrombosis. These children frequently require long-term parenteral nutrition necessitating a functional central venous catheter. Unfortunately, they seem to have an increased incidence of central venous thrombosis compared to other patient groups. A preliminary study that I conducted identified a high incidence of acquired thrombophilia in these children due likely to both systemic inflammation and underlying compromised liver function. I am currently studying the best way to prevent venous thrombosis in these patients including screening and potential anticoagulation.

Grants

"Targeted probiotic therapy to improve the gut microbiota and growth in children with short bowel syndrome"; ASPEN Rhoads Foundation Grant; 1/2017- 1/2018.

"Role of intestial microbiota in children with intestinal failure and bacterial overgrowth"; APSA Foundation Grant; 7/2014- 7/2015.

"The role of the intestinal microbiota in the development of cholestatic liver disease in infants with short bowel syndrome"; Discovery Fund Grant; 1/2016- 1/2017.

Honours & Awards

Gut Microbiota Dysbiosis is Associated with Poor Growth in Children with Show Bowel Syndrome; 2015- 2017.

Provider of the Month Award for the provider who best fulfills the hospital mission; Children's Medical Center, Dallas, Texas; 2016.

Poster with Distinction, International Pediatric Intestinal Failure and Rehabilitation Symposium; 2016.

Our Research

At BC Children’s, we are making discoveries that save lives and transform health care for children in our province and around the world. Our research portfolio includes basic, clinical, population, and public health research.

EXPLORE OUR RESEARCH

Stay in the Know

Sign up for compelling stories about innovative science, the doctors and researchers who turn ideas into discoveries and treatments, and the kids and families whose lives are changed.

This field is for validation purposes and should be left unchanged.