Overview

My research interests involve investigation of cognitive and other neurobehavioral impairments in mental disorders including bipolar disorder and schizophrenia. Specific areas of inquiry include the study of deficits in executive, memory, and self-regulatory or metacognitive functions in these disorders. I am also interested in investigating longitudinal changes in neuropsychological functioning early in the course of bipolar disorder, and determining the extent to which identified cognitive deficits predict functional outcomes in daily life. A final area of interest involves the study of the association between specific psychiatric symptoms and underlying core cognitive impairments in psychotic and affective disorders.

Publications

A longitudinal study of the relationships between mood symptoms, body mass index, and serum adipokines in bipolar disorder
Journal of Clinical Psychiatry
Bond, D.J. and Andreazza, A.C. and Hughes, J. and Dhanoa, T. and Torres, I.J. and Kozicky, J.-M. and Young, L.T. and Lam, R.W. and Yatham, L.N.
DOI: 10.4088/JCP.15m10189
2017

Lower cognitive functioning as a predictor of weight gain in bipolar disorder: a 12-month study
Acta Psychiatrica Scandinavica
Bond, D.J. and Torres, I.J. and Lee, S.S. and Kozicky, J.-M. and Silveira, L.E. and Dhanoa, T. and Lam, R.W. and Yatham, L.N.
DOI: 10.1111/acps.12674
2017

Trajectories of body mass index change in first episode of mania: 3-year data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)
Journal of Affective Disorders
Hu, C. and Torres, I.J. and Qian, H. and Wong, H. and Halli, P. and Dhanoa, T. and Ahn, S. and Wang, G. and Bond, D.J. and Lam, R.W. and Yatham, L.N.
DOI: 10.1016/j.jad.2016.08.048
2017

Lurasidone versus treatment as usual for cognitive impairment in euthymic patients with bipolar I disorder: a randomised, open-label, pilot study
The Lancet Psychiatry
Yatham, L.N. and Mackala, S. and Basivireddy, J. and Ahn, S. and Walji, N. and Hu, C. and Lam, R.W. and Torres, I.J.
DOI: 10.1016/S2215-0366(17)30046-9
2017

Neuroprogression and episode recurrence in bipolar I disorder: A study of gray matter volume changes in first-episode mania and association with clinical outcome
Bipolar Disorders
Kozicky, J.-M. and McGirr, A. and Bond, D.J. and Gonzalez, M. and Silveira, L.E. and Keramatian, K. and Torres, I.J. and Lam, R.W. and Yatham, L.N.
DOI: 10.1111/bdi.12437
2016

Relationship between body mass index and hippocampal glutamate/glutamine in bipolar disorder
British Journal of Psychiatry
Bond, D.J. and Da Silveira, L.E. and MacMillan, E.L. and Torres, I.J. and Lang, D.J. and Su, W. and Honer, W.G. and Lam, R.W. and Yatham, L.N.
DOI: 10.1192/bjp.bp.115.163360
2016

Association of peripheral inflammation with body mass index and depressive relapse in bipolar disorder
Psychoneuroendocrinology
Bond, D.J. and Andreazza, A.C. and Hughes, J. and Dhanoa, T. and Torres, I.J. and Kozicky, J.-M. and Young, L.T. and Lam, R.W. and Yatham, L.N.
DOI: 10.1016/j.psyneuen.2015.12.012
2016

Metacognitive knowledge and experience in recently diagnosed patients with bipolar disorder
Journal of Clinical and Experimental Neuropsychology
Torres, I.J. and Mackala, S.A. and Kozicky, J.-M. and Yatham, L.N.
DOI: 10.1080/13803395.2016.1161733
2016

Are cognitive deficits similar in remitted early bipolar I disorder patients treated with lithium or valproate? Data from the STOP-EM study
European Neuropsychopharmacology
Muralidharan, K., Kozicky, J.-M., Bücker, J., Silveira, L.E., Torres, I.J., Yatham, L.N.
DOI: 10.1016/j.euroneuro.2014.09.005
2015

Verbal memory impairment in new onset bipolar disorder: Relationship with frontal and medial temporal morphology
World Journal of Biological Psychiatry
Chakrabarty, T. and Kozicky, J.-M. and Torres, I.J. and Lam, R.W. and Yatham, L.N.
DOI: 10.3109/15622975.2014.1000373
2015

Response inhibition and interference control in patients with bipolar I disorder and first-degree relatives
Bipolar Disorders
Hidiroglu, C., Torres, I.J., Er, A., Isik, G., Yalin, N., Yatham, L.N., Ceylan, D., Özerdem, A.
DOI: 10.1111/bdi.12335
2015

Erratum: The Association between Subjective Cognitive Functioning and Quality of Life in Bipolar Disorder (Archives of Clinical Neuropsychology (2015) 29:6 (180))
Archives of Clinical Neuropsychology
Mackala, S. and Ahn, S. and Hidiro?lu, C. and Michalak, E. and Yatham, L. and Torres, I.
DOI: 10.1093/arclin/acu067
2015

Body mass index-related regional gray and white matter volume reductions in first-episode mania patients
Biological Psychiatry
Bond, D.J. and Ha, T.H. and Lang, D.J. and Su, W. and Torres, I.J. and Honer, W.G. and Lam, R.W. and Yatham, L.N.
DOI: 10.1016/j.biopsych.2013.08.030
2014

Cognitive change in the year after a first manic episode: Association between clinical outcome and cognitive performance early in the course of bipolar I disorder
Journal of Clinical Psychiatry
Kozicky, J.-M. and Torres, I.J. and Silveira, L.E. and Bond, D.J. and Lam, R.W. and Yatham, L.N.
DOI: 10.4088/JCP.13m08928
2014

Sex differences in cognitive functioning in patients with bipolar disorder who recently recovered from a first episode of mania: Data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)
Journal of Affective Disorders
Bücker, J., Popuri, S., Muralidharan, K., Kozicky, J.-M., Baitz, H.A., Honer, W.G., Torres, I.J., Yatham, L.N.
DOI: 10.1016/j.jad.2013.10.044
2014

Neurocognitive functioning in overweight and obese patients with bipolar disorder: Data from the systematic treatment optimization program for early mania (STOP-EM)
Canadian Journal of Psychiatry
Silveira, L.E., Kozicky, J.-M., Muralidharan, K., Bücker, J., Torres, I.J., Bond, D.J., Kapczinski, F., Kauer-Sant, M., Lam, R.W., Yatham, L.N.
2014

Long-term neuropsychological safety of subgenual cingulate gyrus deep brain stimulation for treatment-resistant depression
Journal of Neuropsychiatry and Clinical Neurosciences
Bogod, N.M. and Sinden, M. and Woo, C. and DeFreitas, V.G. and Torres, I.J. and Howard, A.K. and Ilcewicz-Klimek, M.I. and Honey, C.R. and Yatham, L.N. and Lam, R.W.
DOI: 10.1176/appi.neuropsych.12110287
2014

12-month longitudinal cognitive functioning in patients recently diagnosed with bipolar disorder
Bipolar Disorders
Torres, I.J. and Kozicky, J. and Popuri, S. and Bond, D.J. and Honer, W.G. and Lam, R.W. and Yatham, L.N.
DOI: 10.1111/bdi.12154
2014

Impact of depressive episodes on cognitive deficits in early bipolar disorder: Data from the systematic treatment optimization programme for early mania (STOP-EM)
British Journal of Psychiatry
Muralidharan, K., Torres, I.J., Silveira, L.E., Kozicky, J.-M., Bücker, J., Fernando, N., Yatham, L.N.
DOI: 10.1192/bjp.bp.113.135525
2014

Cognitive performance and quality of life early in the course of bipolar disorder
Journal of Affective Disorders
Mackala, S.A. and Torres, I.J. and Kozicky, J. and Michalak, E.E. and Yatham, L.N.
DOI: 10.1016/j.jad.2014.06.045
2014

Childhood maltreatment and corpus callosum volume in recently diagnosed patients with bipolar I disorder: Data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)
Journal of Psychiatric Research
Bücker, J., Muralidharan, K., Torres, I.J., Su, W., Kozicky, J., Silveira, L.E., Bond, D.J., Honer, W.G., Kauer-Sant'Anna, M., Lam, R.W., Yatham, L.N.
DOI: 10.1016/j.jpsychires.2013.10.012
2014

The relationship between clinical outcomes and quality of life in first-episode mania: A longitudinal analysis
Bipolar Disorders
Michalak, E.E. and Torres, I.J. and Bond, D.J. and Lam, R.W. and Yatham, L.N.
DOI: 10.1111/bdi.12049
2013

Relationship between frontostriatal morphology and executive function deficits in bipolar I disorder following a first manic episode: Data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)
Bipolar Disorders
Kozicky, J.-M. and Ha, T.H. and Torres, I.J. and Bond, D.J. and Honer, W.G. and Lam, R.W. and Yatham, L.N.
DOI: 10.1111/bdi.12103
2013

The impact of childhood trauma on cognitive functioning in patients recently recovered from a first manic episode: Data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM).
Journal of Affective Disorders
Bücker, J., Kozicky, J., Torres, I.J., Kauer-Sant'Anna, M., Silveira, L.E., Bond, D.J., Lam, R.W., Yatham, L.N.
DOI: 10.1016/j.jad.2012.11.022
2013

Comparison of neuropsychological effects of adjunctive risperidone or quetiapine in euthymic patients with bipolar i disorder
International Clinical Psychopharmacology
Kozicky, J.-M. and Torres, I.J. and Bond, D.J. and Lam, R.W. and Yatham, L.N.
DOI: 10.1097/YIC.0b013e32834e3bea
2012

The association of elevated body mass index with reduced brain volumes in first-episode mania
Biological Psychiatry
Bond, D.J. and Lang, D.J. and Noronha, M.M. and Kunz, M. and Torres, I.J. and Su, W. and Honer, W.G. and Lam, R.W. and Yatham, L.N.
DOI: 10.1016/j.biopsych.2011.02.025
2011

Structural pathology underlying neuroendocrine dysfunction in schizophrenia
Behavioural Brain Research
Goldman, M.B., Wang, L., Wachi, C., Daudi, S., Csernansky, J., Marlow-O'Connor, M., Keedy, S., Torres, I.
DOI: 10.1016/j.bbr.2010.11.025
2011

Relationship between cognitive functioning and 6-month clinical and functional outcome in patients with first manic episode bipolar i disorder
Psychological Medicine
Torres, I.J. and Defreitas, C.M. and Defreitas, V.G. and Bond, D.J. and Kunz, M. and Honer, W.G. and Lam, R.W. and Yatham, L.N.
DOI: 10.1017/S0033291710001613
2011

Neurocognitive functioning in patients with bipolar I disorder recently recovered from a first manic episode
Journal of Clinical Psychiatry
Torres, I.J., DeFreitas, V.G., DeFreitas, C.M., Kauer-Sant'Anna, M., Bond, D.J., Honer, W.G., Lam, R.W., Yatham, L.N.
DOI: 10.4088/JCP.08m04997yel
2010

The association of weight gain with mood symptoms and functional outcomes following a first manic episode: Prospective 12-month data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)
Bipolar Disorders
Bond, D.J. and Kunz, M. and Torres, I.J. and Lam, R.W. and Yatham, L.N.
DOI: 10.1111/j.1399-5618.2010.00855.x
2010

Neurocognition in Bipolar Disorder
Bipolar Disorder: Clinical and Neurobiological Foundations
Torres, I.J. and Malhi, G.S.
DOI: 10.1002/9780470661277.ch8
2010

The International Society for Bipolar Disorders-Battery for Assessment of Neurocognition (ISBD-BANC)
Bipolar Disorders
Yatham, L.N., Torres, I.J., Malhi, G.S., Frangou, S., Glahn, D.C., Bearden, C.E., Burdick, K.E., Martínez-Arán, A., Dittmann, S., Goldberg, J.F., Ozerdem, A., Aydemir, O., Chengappa, K.N.R.
DOI: 10.1111/j.1399-5618.2010.00830.x
2010

Symptomatic determinants of insight in schizophrenia spectrum disorders
Comprehensive Psychiatry
Buchy, L. and Torres, I.J. and Liddle, P.F. and Woodward, T.S.
DOI: 10.1016/j.comppsych.2009.01.007
2009

Neuropsychological Impairment in Patients With Schizophrenia and Evidence of Hyponatremia and Polydipsia
Neuropsychology
Torres, I.J., Keedy, S., Marlow-O'Connor, M., Beenken, B., Goldman, M.B.
DOI: 10.1037/a0014481
2009

Course and outcome after the first manic episode in patients with bipolar disorder: Prospective 12-month data from the systematic treatment optimization program for early mania project
Canadian Journal of Psychiatry
Yatham, L.N., Kauer-SanT'Anna, M., Bond, D.J., Lam, R.W., Torres, I.
2009

Preferential semantic fluency impairment is related to hallucinations, but not formal thought disorder
Schizophrenia Research
DeFreitas, C.M. and Dunaway, L.A. and Torres, I.J.
DOI: 10.1016/j.schres.2008.08.020
2009

Diminished plasma oxytocin in schizophrenic patients with neuroendocrine dysfunction and emotional deficits
Schizophrenia Research
Goldman, M., Marlow-O'Connor, M., Torres, I., Carter, C.S.
DOI: 10.1016/j.schres.2007.09.019
2008

Neuropsychological functioning in euthymic bipolar disorder: A meta-analysis
Acta Psychiatrica Scandinavica
Torres, I.J. and Boudreau, V.G. and Yatham, L.N.
DOI: 10.1111/j.1600-0447.2007.01055.x
2007

Neuropsychological functioning in euthymic bipolar disorder: a meta-analysis.
Acta psychiatrica Scandinavica. Supplementum
Torres, I.J. and Boudreau, V.G. and Yatham, L.N.
2007

Reduced anterior hippocampal formation volume in hyponatremic schizophrenic patients
Hippocampus
Goldman, M.B., Torres, I.J., Keedy, S., Marlow-O'Connor, M., Beenken, B., Pilla, R.
DOI: 10.1002/hipo.20292
2007

Functional neuroimaging of working memory in schizophrenia: Task performance as a moderating variable
Neuropsychology
Van Snellenberg, J.X. and Torres, I.J. and Thornton, A.E.
DOI: 10.1037/0894-4105.20.5.497
2006

Unawareness of deficits in Alzheimer's disease and other dementias: Operational definitions and empirical findings
Neuropsychology Review
Ecklund-Johnson, E. and Torres, I.
DOI: 10.1007/s11065-005-9026-7
2005

Symptoms and interference from memory in schizophrenia: Evaluation of Frith's model of willed action
Schizophrenia Research
Torres, I.J., O'Leary, D.S., Andreasen, N.C.
DOI: 10.1016/j.schres.2003.08.012
2004

A longitudinal neuropsychological study of partial brain radiation in adults with brain tumors
Neurology
Torres, I.J. and Mundt, A.J. and Sweeney, P.J. and Llanes-Macy, S. and Dunaway, L. and Castillo, M. and Macdonald, R.L.
2003

Transient inability to distinguish between faces: Electrophysiologic studies
Journal of Clinical Neurophysiology
Mundel, T. and Milton, J.G. and Dimitrov, A. and Wilson, H.W. and Pelizzari, C. and Uftring, S. and Torres, I. and Erickson, R.K. and Spire, J.-P. and Towle, V.L.
DOI: 10.1097/00004691-200304000-00003
2003

Effects of retroactive and proactive interference on word list recall in schizophrenia
Journal of the International Neuropsychological Society
Torres, I.J., Flashman, L.A., O'Leary, D.S., Andreasen, N.C.
DOI: 10.1017/S1355617701744049
2001

Auditory and visual attention assessed with PET
Human Brain Mapping
O'Leary, D.S., Andreasen, N.C., Hurtig, R.R., Torres, I.J., Flashman, L.A., Kesler, M.L., Arndt, S.V., Cizadlo, T.J., Ponto, L.L.B., Watkins, G.L., Hichwa, R.D.
1997

Lack of an association between delayed memory and hippocampal and temporal lobe size in patients with schizophrenia and healthy controls
Biological Psychiatry
Torres, I.J., Flashman, L.A., O'Leary, D.S., Swayze II, V., Andreasen, N.C.
DOI: 10.1016/S0006-3223(97)00024-3
1997