- Overview
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My research interests involve investigation of cognitive and other neurobehavioral impairments in psychiatric illnesses including bipolar disorder and schizophrenia. Specific areas of inquiry include the study of executive, memory, and self-regulatory or metacognitive functions in these disorders, and cognitive functioning in treatment resistant psychosis. I am also interested in investigating longitudinal changes in neuropsychological functioning early in the course of bipolar disorder, and determining the extent to which identified cognitive deficits predict functional outcomes in daily life. A final area of interest involves the study of the association between specific psychiatric symptoms and underlying core cognitive impairments in psychotic and affective disorders.
- Publications
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Effects of intermittent theta-burst transcranial magnetic stimulation on cognition and hippocampal volumes in bipolar depression
Dialogues in Clinical Neuroscience
Ivan J. Torres and Ruiyang Ge and Alexander McGirr and Fidel Vila-Rodriguez and Sharon Ahn and Jayasree Basivireddy and Nazlin Walji and Sophia Frangou and Raymond W. Lam and Lakshmi N. Yatham
DOI: 10.1080/19585969.2023.2186189
12/2023Predicting recurrence of major depressive episodes using the Depression Implicit Association Test: A Canadian biomarker integration network in depression (CAN-BIND) report
Psychiatry Research
Katerina Rnic and Joelle LeMoult and Ivan J. Torres and Trisha Chakrabarty and Jane Foster and Benicio N. Frey and Kate L. Harkness and Keith Ho and Qingqin S. Li and Roumen Milev and Lena C. Quilty and Susan Rotzinger and Claudio N. Soares and Rudolf Uher and Sidney H. Kennedy and Raymond W. Lam
DOI: 10.1016/j.psychres.2023.115606
12/2023Co-design of a Virtual Reality Cognitive Remediation Program for Depression (bWell-D) With Patient End Users and Clinicians: Qualitative Interview Study Among Patients and Clinicians
JMIR Serious Games
Maria Elena Hernandez Hernandez and Erin Michalak and Nusrat Choudhury and Mark Hewko and Ivan Torres and Mahesh Menon and Raymond W Lam and Trisha Chakrabarty
DOI: 10.2196/43904
04/2023Weight gain as a risk factor for progressive neurochemical abnormalities in first episode mania patients: a longitudinal magnetic resonance spectroscopy study
Psychological Medicine
David J. Bond and Leonardo E. Silveira and Ivan J. Torres and Raymond W. Lam and Lakshmi N. Yatham
DOI: 10.1017/S0033291721000544
12/2022Subjective cognitive functioning, depressive symptoms, and objective cognitive functioning in people with treatment-resistant psychosis
Cognitive Neuropsychiatry
Daniah Zumrawi and Brianne L. Glazier and Olga Leonova and Mahesh Menon and Ric Procyshyn and Randall White and Robert Stowe and William G. Honer and Ivan J. Torres
DOI: 10.1080/13546805.2022.2108389
11/2022Co-design of a Virtual Reality Cognitive Remediation Program for Depression (bWell-D) With Patient End Users and Clinicians: Qualitative Interview Study Among Patients and Clinicians (Preprint)
Maria Elena Hernandez Hernandez and Erin Michalak and Nusrat Choudhury and Mark Hewko and Ivan Torres and Mahesh Menon and Raymond W Lam and Trisha Chakrabarty
DOI: 10.2196/preprints.43904
10/2022Criterion validity of the brief test of adult cognition by telephone (BTACT) for mild traumatic brain injury
Brain Injury
Molly Cairncross and Hiresh Gindwani and Anna Rita Egbert and Ivan J. Torres and James S. Hutchison and Kristen Dams O’Connor and William J. Panenka and Jeffrey R. Brubacher and Louise Meddings and Lexynn Kwan and Keith O. Yeates and Robin Green and Noah D. Silverberg
DOI: 10.1080/02699052.2022.2109744
09/2022Association between discrepancy in objective and subjective cognitive abilities and treatment response in patients with major depressive disorder: A CAN-BIND-1 study report
Journal of Affective Disorders
Katerina Rnic and Young-Eun Jung and Ivan Torres and Trisha Chakrabarty and Joelle LeMoult and Anthony L. Vaccarino and Emma Morton and Venkat Bhat and Peter Giacobbe and Shane McInerney and Benicio N. Frey and Roumen V. Milev and Daniel Müller and Arun V. Ravindran and Susan Rotzinger and Sidney H. Kennedy and Raymond W. Lam
DOI: 10.1016/j.jad.2021.09.002
12/2021Cognitive subgroups in first episode bipolar I disorder: Relation to clinical and brain volumetric variables
Acta Psychiatrica Scandinavica
Trisha Chakrabarty and Ivan J. Torres and Weizhong W. Su and Richard Sawatzky and Kamyar Keramatian and Lakshmi N. Yatham
DOI: 10.1111/acps.13245
02/2021Metacognitive knowledge and experience across multiple cognitive domains in euthymic bipolar disorder
European Psychiatry
Ivan J. Torres and Ceren Hidiroglu and Sylvia A. Mackala and Sharon Ahn and Lakshmi N. Yatham and Eysegul Ozerdem and Erin E. Michalak
DOI: 10.1192/j.eurpsy.2021.31
2021Assessment of Prorated Scoring of an Abbreviated Protocol for the National Institutes of Health Toolbox Cognition Battery
Journal of the International Neuropsychological Society
Alexander D. Rebchuk and Arshia Alimohammadi and Michelle Yuan and Molly Cairncross and Ivan J. Torres and Noah D. Silverberg and Thalia S. Field
DOI: 10.1017/S1355617720001010
11/2020Three-year longitudinal cognitive functioning in patients recently diagnosed with bipolar disorder
Acta Psychiatrica Scandinavica
I. J. Torres and H. Qian and J. Basivireddy and T. Chakrabarty and H. Wong and R. W. Lam and L. N. Yatham
DOI: 10.1111/acps.13141
02/2020Trajectories of body mass index change in first episode of mania: 3-year data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)
Journal of Affective Disorders
Hu, C. and Torres, I.J. and Qian, H. and Wong, H. and Halli, P. and Dhanoa, T. and Ahn, S. and Wang, G. and Bond, D.J. and Lam, R.W. and Yatham, L.N.
DOI: 10.1016/j.jad.2016.08.048
2017Lower cognitive functioning as a predictor of weight gain in bipolar disorder: a 12-month study
Acta Psychiatrica Scandinavica
Bond, D.J. and Torres, I.J. and Lee, S.S. and Kozicky, J.-M. and Silveira, L.E. and Dhanoa, T. and Lam, R.W. and Yatham, L.N.
DOI: 10.1111/acps.12674
2017Lurasidone versus treatment as usual for cognitive impairment in euthymic patients with bipolar I disorder: a randomised, open-label, pilot study
The Lancet Psychiatry
Yatham, L.N. and Mackala, S. and Basivireddy, J. and Ahn, S. and Walji, N. and Hu, C. and Lam, R.W. and Torres, I.J.
DOI: 10.1016/S2215-0366(17)30046-9
2017A longitudinal study of the relationships between mood symptoms, body mass index, and serum adipokines in bipolar disorder
Journal of Clinical Psychiatry
Bond, D.J. and Andreazza, A.C. and Hughes, J. and Dhanoa, T. and Torres, I.J. and Kozicky, J.-M. and Young, L.T. and Lam, R.W. and Yatham, L.N.
DOI: 10.4088/JCP.15m10189
2017Neuroprogression and episode recurrence in bipolar I disorder: A study of gray matter volume changes in first-episode mania and association with clinical outcome
Bipolar Disorders
Kozicky, J.-M. and McGirr, A. and Bond, D.J. and Gonzalez, M. and Silveira, L.E. and Keramatian, K. and Torres, I.J. and Lam, R.W. and Yatham, L.N.
DOI: 10.1111/bdi.12437
2016Metacognitive knowledge and experience in recently diagnosed patients with bipolar disorder
Journal of Clinical and Experimental Neuropsychology
Torres, I.J. and Mackala, S.A. and Kozicky, J.-M. and Yatham, L.N.
DOI: 10.1080/13803395.2016.1161733
2016Relationship between body mass index and hippocampal glutamate/glutamine in bipolar disorder
British Journal of Psychiatry
Bond, D.J. and Da Silveira, L.E. and MacMillan, E.L. and Torres, I.J. and Lang, D.J. and Su, W. and Honer, W.G. and Lam, R.W. and Yatham, L.N.
DOI: 10.1192/bjp.bp.115.163360
2016Association of peripheral inflammation with body mass index and depressive relapse in bipolar disorder
Psychoneuroendocrinology
Bond, D.J. and Andreazza, A.C. and Hughes, J. and Dhanoa, T. and Torres, I.J. and Kozicky, J.-M. and Young, L.T. and Lam, R.W. and Yatham, L.N.
DOI: 10.1016/j.psyneuen.2015.12.012
2016Are cognitive deficits similar in remitted early bipolar I disorder patients treated with lithium or valproate? Data from the STOP-EM study
European Neuropsychopharmacology
Muralidharan, K. and Kozicky, J.-M. and Bücker, J. and Silveira, L.E. and Torres, I.J. and Yatham, L.N.
DOI: 10.1016/j.euroneuro.2014.09.005
2015Erratum: The Association between Subjective Cognitive Functioning and Quality of Life in Bipolar Disorder (Archives of Clinical Neuropsychology (2015) 29:6 (180))
Archives of Clinical Neuropsychology
Mackala, S. and Ahn, S. and Hidiro?lu, C. and Michalak, E. and Yatham, L. and Torres, I.
DOI: 10.1093/arclin/acu067
2015Verbal memory impairment in new onset bipolar disorder: Relationship with frontal and medial temporal morphology
World Journal of Biological Psychiatry
Chakrabarty, T. and Kozicky, J.-M. and Torres, I.J. and Lam, R.W. and Yatham, L.N.
DOI: 10.3109/15622975.2014.1000373
2015Response inhibition and interference control in patients with bipolar I disorder and first-degree relatives
Bipolar Disorders
Hidiro?lu, C. and Torres, I.J. and Er, A. and I?ik, G. and Yalin, N. and Yatham, L.N. and Ceylan, D. and Özerdem, A.
DOI: 10.1111/bdi.12335
2015Neurocognitive functioning in overweight and obese patients with bipolar disorder: Data from the systematic treatment optimization program for early mania (STOP-EM)
Canadian Journal of Psychiatry
Silveira, L.E. and Kozicky, J.-M. and Muralidharan, K. and Bücker, J. and Torres, I.J. and Bond, D.J. and Kapczinski, F. and Kauer-Sant, M. and Lam, R.W. and Yatham, L.N.
2014Sex differences in cognitive functioning in patients with bipolar disorder who recently recovered from a first episode of mania: Data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)
Journal of Affective Disorders
Bücker, J. and Popuri, S. and Muralidharan, K. and Kozicky, J.-M. and Baitz, H.A. and Honer, W.G. and Torres, I.J. and Yatham, L.N.
DOI: 10.1016/j.jad.2013.10.044
2014Cognitive change in the year after a first manic episode: Association between clinical outcome and cognitive performance early in the course of bipolar I disorder
Journal of Clinical Psychiatry
Kozicky, J.-M. and Torres, I.J. and Silveira, L.E. and Bond, D.J. and Lam, R.W. and Yatham, L.N.
DOI: 10.4088/JCP.13m08928
2014Long-term neuropsychological safety of subgenual cingulate gyrus deep brain stimulation for treatment-resistant depression
Journal of Neuropsychiatry and Clinical Neurosciences
Bogod, N.M. and Sinden, M. and Woo, C. and DeFreitas, V.G. and Torres, I.J. and Howard, A.K. and Ilcewicz-Klimek, M.I. and Honey, C.R. and Yatham, L.N. and Lam, R.W.
DOI: 10.1176/appi.neuropsych.12110287
2014Childhood maltreatment and corpus callosum volume in recently diagnosed patients with bipolar I disorder: Data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)
Journal of Psychiatric Research
Bücker, J. and Muralidharan, K. and Torres, I.J. and Su, W. and Kozicky, J. and Silveira, L.E. and Bond, D.J. and Honer, W.G. and Kauer-Sant'Anna, M. and Lam, R.W. and Yatham, L.N.
DOI: 10.1016/j.jpsychires.2013.10.012
2014Cognitive performance and quality of life early in the course of bipolar disorder
Journal of Affective Disorders
Mackala, S.A. and Torres, I.J. and Kozicky, J. and Michalak, E.E. and Yatham, L.N.
DOI: 10.1016/j.jad.2014.06.045
2014Impact of depressive episodes on cognitive deficits in early bipolar disorder: Data from the systematic treatment optimization programme for early mania (STOP-EM)
British Journal of Psychiatry
Muralidharan, K. and Torres, I.J. and Silveira, L.E. and Kozicky, J.-M. and Bücker, J. and Fernando, N. and Yatham, L.N.
DOI: 10.1192/bjp.bp.113.135525
201412-month longitudinal cognitive functioning in patients recently diagnosed with bipolar disorder
Bipolar Disorders
Torres, I.J. and Kozicky, J. and Popuri, S. and Bond, D.J. and Honer, W.G. and Lam, R.W. and Yatham, L.N.
DOI: 10.1111/bdi.12154
2014Body mass index-related regional gray and white matter volume reductions in first-episode mania patients
Biological Psychiatry
Bond, D.J. and Ha, T.H. and Lang, D.J. and Su, W. and Torres, I.J. and Honer, W.G. and Lam, R.W. and Yatham, L.N.
DOI: 10.1016/j.biopsych.2013.08.030
2014The impact of childhood trauma on cognitive functioning in patients recently recovered from a first manic episode: Data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM).
Journal of Affective Disorders
Bücker, J. and Kozicky, J. and Torres, I.J. and Kauer-Sant'Anna, M. and Silveira, L.E. and Bond, D.J. and Lam, R.W. and Yatham, L.N.
DOI: 10.1016/j.jad.2012.11.022
2013Relationship between frontostriatal morphology and executive function deficits in bipolar I disorder following a first manic episode: Data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)
Bipolar Disorders
Kozicky, J.-M. and Ha, T.H. and Torres, I.J. and Bond, D.J. and Honer, W.G. and Lam, R.W. and Yatham, L.N.
DOI: 10.1111/bdi.12103
2013The relationship between clinical outcomes and quality of life in first-episode mania: A longitudinal analysis
Bipolar Disorders
Michalak, E.E. and Torres, I.J. and Bond, D.J. and Lam, R.W. and Yatham, L.N.
DOI: 10.1111/bdi.12049
2013Comparison of neuropsychological effects of adjunctive risperidone or quetiapine in euthymic patients with bipolar i disorder
International Clinical Psychopharmacology
Kozicky, J.-M. and Torres, I.J. and Bond, D.J. and Lam, R.W. and Yatham, L.N.
DOI: 10.1097/YIC.0b013e32834e3bea
2012The association of elevated body mass index with reduced brain volumes in first-episode mania
Biological Psychiatry
Bond, D.J. and Lang, D.J. and Noronha, M.M. and Kunz, M. and Torres, I.J. and Su, W. and Honer, W.G. and Lam, R.W. and Yatham, L.N.
DOI: 10.1016/j.biopsych.2011.02.025
2011Structural pathology underlying neuroendocrine dysfunction in schizophrenia
Behavioural Brain Research
Goldman, M.B. and Wang, L. and Wachi, C. and Daudi, S. and Csernansky, J. and Marlow-O'Connor, M. and Keedy, S. and Torres, I.
DOI: 10.1016/j.bbr.2010.11.025
2011Relationship between cognitive functioning and 6-month clinical and functional outcome in patients with first manic episode bipolar i disorder
Psychological Medicine
Torres, I.J. and Defreitas, C.M. and Defreitas, V.G. and Bond, D.J. and Kunz, M. and Honer, W.G. and Lam, R.W. and Yatham, L.N.
DOI: 10.1017/S0033291710001613
2011Neurocognition in Bipolar Disorder
Bipolar Disorder: Clinical and Neurobiological Foundations
Torres, I.J. and Malhi, G.S.
DOI: 10.1002/9780470661277.ch8
2010The International Society for Bipolar Disorders-Battery for Assessment of Neurocognition (ISBD-BANC)
Bipolar Disorders
Yatham, L.N. and Torres, I.J. and Malhi, G.S. and Frangou, S. and Glahn, D.C. and Bearden, C.E. and Burdick, K.E. and Martínez-Arán, A. and Dittmann, S. and Goldberg, J.F. and Ozerdem, A. and Aydemir, O. and Chengappa, K.N.R.
DOI: 10.1111/j.1399-5618.2010.00830.x
2010Neurocognitive functioning in patients with bipolar I disorder recently recovered from a first manic episode
Journal of Clinical Psychiatry
Torres, I.J. and DeFreitas, V.G. and DeFreitas, C.M. and Kauer-Sant'Anna, M. and Bond, D.J. and Honer, W.G. and Lam, R.W. and Yatham, L.N.
DOI: 10.4088/JCP.08m04997yel
2010The association of weight gain with mood symptoms and functional outcomes following a first manic episode: Prospective 12-month data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)
Bipolar Disorders
Bond, D.J. and Kunz, M. and Torres, I.J. and Lam, R.W. and Yatham, L.N.
DOI: 10.1111/j.1399-5618.2010.00855.x
2010Course and outcome after the first manic episode in patients with bipolar disorder: Prospective 12-month data from the systematic treatment optimization program for early mania project
Canadian Journal of Psychiatry
Yatham, L.N. and Kauer-SanT'Anna, M. and Bond, D.J. and Lam, R.W. and Torres, I.
2009Preferential semantic fluency impairment is related to hallucinations, but not formal thought disorder
Schizophrenia Research
DeFreitas, C.M. and Dunaway, L.A. and Torres, I.J.
DOI: 10.1016/j.schres.2008.08.020
2009Symptomatic determinants of insight in schizophrenia spectrum disorders
Comprehensive Psychiatry
Buchy, L. and Torres, I.J. and Liddle, P.F. and Woodward, T.S.
DOI: 10.1016/j.comppsych.2009.01.007
2009Neuropsychological Impairment in Patients With Schizophrenia and Evidence of Hyponatremia and Polydipsia
Neuropsychology
Torres, I.J. and Keedy, S. and Marlow-O'Connor, M. and Beenken, B. and Goldman, M.B.
DOI: 10.1037/a0014481
2009Diminished plasma oxytocin in schizophrenic patients with neuroendocrine dysfunction and emotional deficits
Schizophrenia Research
Goldman, M. and Marlow-O'Connor, M. and Torres, I. and Carter, C.S.
DOI: 10.1016/j.schres.2007.09.019
2008Neuropsychological functioning in euthymic bipolar disorder: a meta-analysis.
Acta psychiatrica Scandinavica. Supplementum
Torres, I.J. and Boudreau, V.G. and Yatham, L.N.
2007Reduced anterior hippocampal formation volume in hyponatremic schizophrenic patients
Hippocampus
Goldman, M.B. and Torres, I.J. and Keedy, S. and Marlow-O'Connor, M. and Beenken, B. and Pilla, R.
DOI: 10.1002/hipo.20292
2007Neuropsychological functioning in euthymic bipolar disorder: A meta-analysis
Acta Psychiatrica Scandinavica
Torres, I.J. and Boudreau, V.G. and Yatham, L.N.
DOI: 10.1111/j.1600-0447.2007.01055.x
2007Functional neuroimaging of working memory in schizophrenia: Task performance as a moderating variable
Neuropsychology
Van Snellenberg, J.X. and Torres, I.J. and Thornton, A.E.
DOI: 10.1037/0894-4105.20.5.497
2006Unawareness of deficits in Alzheimer's disease and other dementias: Operational definitions and empirical findings
Neuropsychology Review
Ecklund-Johnson, E. and Torres, I.
DOI: 10.1007/s11065-005-9026-7
2005Symptoms and interference from memory in schizophrenia: Evaluation of Frith's model of willed action
Schizophrenia Research
Torres, I.J. and O'Leary, D.S. and Andreasen, N.C.
DOI: 10.1016/j.schres.2003.08.012
2004A longitudinal neuropsychological study of partial brain radiation in adults with brain tumors
Neurology
Torres, I.J. and Mundt, A.J. and Sweeney, P.J. and Llanes-Macy, S. and Dunaway, L. and Castillo, M. and Macdonald, R.L.
2003Transient inability to distinguish between faces: Electrophysiologic studies
Journal of Clinical Neurophysiology
Mundel, T. and Milton, J.G. and Dimitrov, A. and Wilson, H.W. and Pelizzari, C. and Uftring, S. and Torres, I. and Erickson, R.K. and Spire, J.-P. and Towle, V.L.
DOI: 10.1097/00004691-200304000-00003
2003Effects of retroactive and proactive interference on word list recall in schizophrenia
Journal of the International Neuropsychological Society
Torres, I.J. and Flashman, L.A. and O'Leary, D.S. and Andreasen, N.C.
DOI: 10.1017/S1355617701744049
2001Auditory and visual attention assessed with PET
Human Brain Mapping
O'Leary, D.S. and Andreasen, N.C. and Hurtig, R.R. and Torres, I.J. and Flashman, L.A. and Kesler, M.L. and Arndt, S.V. and Cizadlo, T.J. and Ponto, L.L.B. and Watkins, G.L. and Hichwa, R.D.
1997Lack of an association between delayed memory and hippocampal and temporal lobe size in patients with schizophrenia and healthy controls
Biological Psychiatry
Torres, I.J. and Flashman, L.A. and O'Leary, D.S. and Swayze II, V. and Andreasen, N.C.
DOI: 10.1016/S0006-3223(97)00024-3
1997
Congratulations to the recipients of the 2023 Outstanding Achievement Awards and the Clinical & Translational Research Seed Grant
BC Children’s Hospital Research Institute is pleased to congratulate the recipients of the 2023 Outstanding Achievement Awards and the Clinical & Translational Research Seed Grant. These programs, generously funded by the BC Children’s Hospital Foundation, play a pivotal role in acknowledging and nurturing excellence within our research community.
