- Overview
-
I am a Pediatric Dentist based at BCCH department of dentistry. I am also the director of the graduate program in Pediatric Dentistry which trains specialists. My research is in the area of developmental malformations that affect the face and teeth. I am particularly focused on the causes of cleft lip with or without cleft palate which affects 1 in 700 babies. Facial clefting is one of the most common birth defects and in the majority of cases, the clefts occur in otherwise healthy babies. Therefore, the causes are complex and difficult to attribute to genetic mutations. I study the environmental effects that predispose an individual to developing a cleft. I primarily use the chicken embryo for this research because I can test the role of specific genes and growth factors in facial development directly in the egg. In addition, I do clinical research on human fetal development and changes to delivery of dental services during the Covid-19 pandemic.
- Publications
-
Resilience of the replacing dentition in adult reptiles
Developmental Biology
Joaquin I. Henriquez and Joy M. Richman
DOI: 10.1016/j.ydbio.2024.07.013
12/2024Colin Dawes In Memoriam: JDR Editor Emeritus and Pioneer in Salivary Research
Journal of Dental Research
J.M. Richman and W.L. Siqueira
DOI: 10.1177/00220345241280026
10/2024Craniofacial studies in chicken embryos confirm the pathogenicity of human FZD2 variants associated with Robinow syndrome
Disease Models & Mechanisms
Shruti S. Tophkhane and Katherine Fu and Esther M. Verheyen and Joy M. Richman
DOI: 10.1242/dmm.050584
06/2024DVL1variants and C-terminal deletions have differential effects on craniofacial development and WNT signaling
Shruti S. Tophkhane and Sarah J. Gignac and Katherine Fu and Esther M. Verheyen and Joy M. Richman
DOI: 10.1101/2024.02.28.582602
02/2024Craniofacial studies in chicken embryos confirm the pathogenicity of Frizzled2 variants associated with Robinow syndrome
Shruti S. Tophkhane and Katherine Fu and Esther M. Verheyen and Joy M. Richman
DOI: 10.1101/2023.11.07.565956
11/2023Mechanistic studies in Drosophila and chicken give new insights into functions of DVL1 in dominant Robinow syndrome
Disease Models & Mechanisms
Sarah J. Gignac and Katja R. MacCharles and Katherine Fu and Kywana Bonaparte and Gamze Akarsu and Thalia W. Barrett and Esther M. Verheyen and Joy M. Richman
DOI: 10.1242/dmm.049844
04/2023Transcriptomic profiling of the adult reptilian dentition sheds light on the genes regulating indefinite tooth replacement
Joaquin Ignacio Henriquez and Stephane Flibotte and Katherine Fu and Edward Zirui-Wang Li and Joy M. Richman
DOI: 10.1101/2022.12.23.521841
12/2022Evolutionarily conserved waves of tooth replacement in the gecko are dependent on local signaling
Kirstin S. Brink and Eric Cytrynbaum and Theresa M. Grieco and Joaquin I. Henriquez and Anna Zhitnitsky and Joy M. Richman
DOI: 10.1101/2022.11.17.513312
11/2022Symmetry and fluctuation of cell movements in neural crest-derived facial mesenchyme
Development
Adrian Danescu and Elisabeth G. Rens and Jaspreet Rehki and Johnathan Woo and Takashi Akazawa and Katherine Fu and Leah Edelstein-Keshet and Joy M. Richman
DOI: 10.1242/dev.193755
05/2021Getting out of an egg: Merging of tooth germs to create an egg tooth in the snake
Developmental Dynamics
Juan M. Fons and Marcia Gaete and Oldrich Zahradnicek and Marie Landova and Hussein Bandali and Eraqi R. Khannoon and Joy M. Richman and Marcela Buchtova and Abigail S. Tucker
DOI: 10.1002/dvdy.120
02/2020JDR Historical Highlights #10
Journal of Dental Research
Nick Jakubovics and Joy Richman
DOI: 10.1177/0022034519864885
09/2019Robinow syndrome skeletal phenotypes caused by the WNT5AC83S variant are due to dominant interference with chondrogenesis
Human Molecular Genetics
Sarah J Gignac and Sara Hosseini-Farahabadi and Takashi Akazawa and Nathan J Schuck and Katherine Fu and Joy M Richman
DOI: 10.1093/hmg/ddz071
07/2019Shedding new light on the mysteries of tooth eruption
Proceedings of the National Academy of Sciences
Joy M. Richman
DOI: 10.1073/pnas.1819412116
01/2019Coordination of bilateral tooth replacement in the juvenile gecko is continuous with in ovo patterning
Evolution & Development
Theresa M. Grieco and Joy M. Richman
DOI: 10.1111/ede.12247
03/2018Craniofacial defects and cleft lip and palate
Wiley
DOI: 10.1002/9780470015902.a0020915.pub2
04/2017Methyltransferase G9A Regulates Osteogenesis via Twist Gene Repression
Journal of Dental Research
Higashihori, N. and Lehnertz, B. and Sampaio, A. and Underhill, T. M. and Rossi, F. and Richman, J. M.
DOI: 10.1177/0022034517716438
2017Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA
Nanomedicine-Nanotechnology Biology and Medicine
Kulkarni, Jayesh A. and Myhre, Johnathan Layne and Chen, Sam and Tam, Yuen Yi C. and Danescu, Adrian and Richman, Joy M. and Cullis, Pieter R.
DOI: 10.1016/j.nano.2016.12.014
2017Abnormal WNT5A Signaling Causes Mandibular Hypoplasia in Robinow Syndrome
Journal of Dental Research
Hosseini-Farahabadi, S. and Gignac, S. J. and Danescu, A. and Fu, K. and Richman, J. M.
DOI: 10.1177/0022034517716916
2017Face Forward: Gene Variants, Pathways, and Therapies for Craniofacial Anomalies
Journal of Dental Research
Richman, J. M. and Schutte, B. C.
DOI: 10.1177/0022034517728076
2017BMP Signaling Regulates the Fate of Chondro-osteoprogenitor Cells in Facial Mesenchyme in a Stage-Specific Manner
Developmental Dynamics
Cela, Petra and Buchtova, Marcela and Vesela, Iva and Fu, Kathy and Bogardi, Jean-Philippe and Song, Yiping and Barlow, Amanda and Buxton, Paul and Medalova, Jirina and Francis-West, Philippa and Richman, Joy M.
DOI: 10.1002/dvdy.24422
2016Pannexin 3 is Required for Late Stage Bone Growth but not for Initiation of Ossification in Avian Embryos
Developmental Dynamics
Bond, Stephen R. and Abramyan, John and Fu, Kathy and Naus, Christian C. and Richman, Joy M.
DOI: 10.1002/dvdy.24425
2016MORN5 Expression during Craniofacial Development and Its Interaction with the BMP and TGF beta Pathways
Frontiers in Physiology
Cela, Petra and Hampl, Marek and Fu, Katherine K. and Kunova Bosakova, Michaela and Krejci, Pavel and Richman, Joy M. and Buchtova, Marcela
DOI: 10.3389/fphys.2016.00378
2016Periodicity and dynamics of tooth replacement from a longitudinal study of leopard geckos
Integrative and Comparative Biology
Grieco, T. M. and Wong, A. C. and Richman, J. M.
2015Recent Insights Into the Morphological Diversity in the Amniote Primary and Secondary Palates
Developmental Dynamics
Abramyan, John and Richman, Joy Marion
DOI: 10.1002/dvdy.24338
2015Analysis of human soft palate morphogenesis supports regional regulation of palatal fusion
Journal of Anatomy
Danescu, Adrian and Mattson, Melanie and Dool, Carly and Diewert, Virginia M. and Richman, Joy M.
DOI: 10.1111/joa.12365
2015Diversity in primary palate ontogeny of amniotes revealed with 3D imaging
Journal of Anatomy
Abramyan, John and Thivichon-Prince, Beatrice and Richman, Joy Marion
DOI: 10.1111/joa.12291
2015Identification and functional analysis of novel facial patterning genes in the duplicated beak chicken embryo
Developmental Biology
Nimmagadda, Suresh and Buchtova, Marcela and Fu, Katherine and Geetha-Loganathan, Poongodi and Hosseini-Farahabadi, Sara and Trachtenberg, Alexander J. and Kuo, Winston Patrick and Vesela, Iva and Richman, Joy M.
DOI: 10.1016/j.ydbio.2015.09.007
2015Avian Facial Morphogenesis Is Regulated by c-Jun N-terminal Kinase/Planar Cell Polarity (JNK/PCP) Wingless-related (WNT) Signaling
Journal of Biological Chemistry
Geetha-Loganathan, Poongodi and Nimmagadda, Suresh and Fu, Katherine and Richman, Joy M.
DOI: 10.1074/jbc.M113.522003
2014Comparative studies on the ontogeny of the primary palate and nasal cavities in birds and mammals
Integrative and Comparative Biology
Abramyan, J. and Cheng, J. and Richman, J. M.
2014Divergent Palate Morphology in Turtles and Birds Correlates With Differences in Proliferation and BMP2 Expression During Embryonic Development
Journal of Experimental Zoology Part B-Molecular and Developmental Evolution
Abramyan, John and Leung, Kelvin Jia-Mien and Richman, Joy Marion
DOI: 10.1002/jez.b.22547
2014Expression, function and regulation of Evi-1 during embryonic avian development
Gene Expression Patterns
Cela, P. and Balkova, S. Moravcova and Bryjova, A. and Horakova, D. and Misek, I. and Richman, J. M. and Buchtova, M.
DOI: 10.1016/j.gep.2013.06.002
2013Biology of tooth replacement in amniotes
International Journal of Oral Science
Whitlock, John A. and Richman, Joy M.
DOI: 10.1038/ijos.2013.36
2013Dual functions for WNT5A during cartilage development and in disease
Matrix Biology
Hosseini-Farahabadi, Sara and Geetha-Loganathan, Poongodi and Fu, Katherine and Nimmagadda, Suresh and Yang, Hoe Joong and Richman, Joy M.
DOI: 10.1016/j.matbio.2013.02.005
2013Sox2 marks epithelial competence to generate teeth in mammals and reptiles
Development
Juuri, Emma and Jussila, Maria and Seidel, Kerstin and Holmes, Scott and Wu, Ping and Richman, Joy and Heikinheimo, Kristiina and Chuong, Cheng-Ming and Arnold, Katrin and Hochedlinger, Konrad and Klein, Ophir and Michon, Frederic and Thesleff, Irma
DOI: 10.1242/dev.089599
2013Craniofacial ontogeny in turtles: the role of bone morphogenetic protein in the loss of palatal shelves
Integrative and Comparative Biology
Abramyan, J. and Leung, K. J. and Merchant-Larios, H. and Richman, J. M.
2013Reptilian Tooth Regeneration
Stem Cells in Craniofacial Development and Regeneration
Richman, J.M. and Whitlock, J.A. and Abramyan, J.
DOI: 10.1002/9781118498026.ch7
2013The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage
Genome Biology
Shaffer, H. Bradley and Minx, Patrick and Warren, Daniel E. and Shedlock, Andrew M. and Thomson, Robert C. and Valenzuela, Nicole and Abramyan, John and Amemiya, Chris T. and Badenhorst, Daleen and Biggar, Kyle K. and Borchert, Glen M. and Botka, Christopher W. and Bowden, Rachel M. and Braun, Edward L. and Bronikowski, Anne M. and Bruneau, Benoit G. and Buck, Leslie T. and Capel, Blanche and Castoe, Todd A. and Czerwinski, Mike and Delehaunty, Kim D. and Edwards, Scott V. and Fronick, Catrina C. and Fujita, Matthew K. and Fulton, Lucinda and Graves, Tina A. and Green, Richard E. and Haerty, Wilfried and Hariharan, Ramkumar and Hernandez, Omar and Hillier, LaDeana W. and Holloway, Alisha K. and Janes, Daniel and Janzen, Fredric J. and Kandoth, Cyriac and Kong, Lesheng and de Koning, A. P. Jason and Li, Yang and Literman, Robert and McGaugh, Suzanne E. and Mork, Lindsey and O'Laughlin, Michelle and Paitz, Ryan T. and Pollock, David D. and Ponting, Chris P. and Radhakrishnan, Srihari and Raney, Brian J. and Richman, Joy M. and St John, John and Schwartz, Tonia and Sethuraman, Arun and Spinks, Phillip Q. and Storey, Kenneth B. and Thane, Nay and Vinar, Tomas and Zimmerman, Laura M. and Warren, Wesley C. and Mardis, Elaine R. and Wilson, Richard K.
DOI: 10.1186/gb-2013-14-3-r28
2013Unicuspid and Bicuspid Tooth Crown Formation in Squamates
Journal of Experimental Zoology Part B-Molecular and Developmental Evolution
Handrigan, Gregory R. and Richman, Joy M.
DOI: 10.1002/jezmde.21438
2011Development of High-Concentration Lipoplexes for In Vivo Gene Function Studies in Vertebrate Embryos
Developmental Dynamics
Geetha-Loganathan, Poongodi and Nimmagadda, Suresh and Hafez, Ismail and Fu, Katherine and Cullis, Pieter R. and Richman, Joy M.
DOI: 10.1002/dvdy.22708
2011Spatiotemporal Localization of Periostin and Its Potential Role in Epithelial-Mesenchymal Transition during Palatal Fusion
Cells Tissues Organs
Kitase, Yukiko and Yamashiro, Keisuke and Fu, Katherine and Richman, Joy M. and Shuler, Charles F.
DOI: 10.1159/000320178
2011Reptilian Tooth Development
Genesis
Richman, Joy M. and Handrigan, Gregory R.
DOI: 10.1002/dvg.20721
2011Tmem26 Is Dynamically Expressed during Palate and Limb Development but Is Not Required for Embryonic Survival
Plos One
Town, Liam and McGlinn, Edwina and Davidson, Tara-Lynne and Browne, Catherine M. and Chawengsaksophak, Kallayanee and Koopman, Peter and Richman, Joy M. and Wicking, Carol
DOI: 10.1371/journal.pone.0025228
2011A network of Wnt, hedgehog and BMP signaling pathways regulates tooth replacement in snakes
Developmental Biology
Handrigan, Gregory R. and Richman, Joy M.
DOI: 10.1016/j.ydbio.2010.09.003
2010Whole Genome Microarray Analysis of Chicken Embryo Facial Prominences
Developmental Dynamics
Buchtova, Marcela and Kuo, Winston Patrick and Nimmagadda, Suresh and Benson, Shari L. and Geetha-Loganathan, Poongodi and Logan, Cairine and Au-Yeung, Timothy and Chiang, Eric and Fu, Katherine and Richman, Joy M.
DOI: 10.1002/dvdy.22135
2010The Function and Regulation of TBX22 in Avian Frontonasal Morphogenesis
Developmental Dynamics
Higashihori, Norihisa and Buchtova, Marcela and Richman, Joy M.
DOI: 10.1002/dvdy.22182
2010Synaptic Localization of Neuroligin 2 in the Rodent Retina: Comparative Study With the Dystroglycan-Containing Complex
Journal of Neuroscience Research
Lui, Leona and Levinson, Joshua N. and Noel, Geoffroy and Handrigan, Gregory R. and Richman, Joy M. and El-Husseini, Alaa and Moukhles, Hakima
DOI: 10.1002/jnr.22258
2010Identification of putative dental epithelial stem cells in a lizard with life-long tooth replacement
Development
Handrigan, Gregory R. and Leung, Kelvin J. and Richman, Joy M.
DOI: 10.1242/dev.052415
2010Autocrine and paracrine Shh signaling are necessary for tooth morphogenesis, but not tooth replacement in snakes and lizards (Squamata)
Developmental Biology
Handrigan, Gregory R. and Richman, Joy M.
DOI: 10.1016/j.ydbio.2009.10.020
2010Novel skeletogenic patterning roles for the olfactory pit
Development
Szabo-Rogers, Heather L. and Geetha-Loganathan, Poongodi and Whiting, Cheryl J. and Nimmagadda, Suresh and Fu, Katherine and Richman, Joy M.
DOI: 10.1242/dev.023978
2009How snakes and lizards replace their teeth: Molecular and embryological scrutiny of tooth cycling in squamates
Integrative and Comparative Biology
Handrigan, G. R. and Buchtova, M. and Leung, K. J. and Richman, J. M.
2009Expression of WNT Signalling Pathway Genes During Chicken Craniofacial Development
Developmental Dynamics
Geetha-Loganathan, Poongodi and Nimmagadda, Suresh and Antoni, Laurent and Fu, Katherine and Whiting, Cheryl J. and Francis-West, Philippa and Richman, Joy M.
DOI: 10.1002/dvdy.21934
2009The Metalloendopeptidase Gene Pitrm1 Is Regulated by Hedgehog Signaling in the Developing Mouse Limb and Is Expressed in Muscle Progenitors
Developmental Dynamics
Town, Liam and McGlinn, Edwina and Fiorenza, Salvatore and Metzis, Vicki and Butterfield, Natalie C. and Richman, Joy M. and Wicking, Carol
DOI: 10.1002/dvdy.22126
2009FGF signals from the nasal pit are necessary for normal facial morphogenesis
Developmental Biology
Szabo-Rogers, Heather L. and Geetha-Loganathan, Poongodi and Nimmagadda, Suresh and Fu, Kathy K. and Richman, Joy M.
DOI: 10.1016/j.ydbio.2008.03.027
2008Expression of the NET family member Zfp503 is regulated by hedgehog and BMP signaling in the limb
Developmental Dynamics
McGlinn, Edwina and Richman, Joy M. and Metzis, Vicki and Town, Liam and Butterfield, Natalie C. and Wainwright, Brandon J. and Wicking, Carol
DOI: 10.1002/dvdy.21508
2008Initiation and patterning of the snake dentition are dependent on Sonic Hedgehog signaling
Developmental Biology
Buchtova, Marcela and Handrigan, Gregory R. and Tucker, Abigail S. and Lozanoff, Scott and Town, Liam and Fu, Katherine and Diewert, Virginia M. and Wicking, Carol and Richman, Joy M.
DOI: 10.1016/j.ydbio.2008.03.004
2008Expression and regulation of the decoy bone morphogenetic protein receptor BAMBI in the developing avian face
Developmental Dynamics
Higashihori, Norihisa and Song, Yiping and Richman, Joy M.
DOI: 10.1002/dvdy.21529
2008Embryonic development of Python sebae - II: Craniofacial microscopic anatomy, cell proliferation and apoptosis
Zoology
Buchtova, Marcela and Boughner, Julia C. and Fu, Katherine and Diewert, Virginia M. and Richman, Joy M.
DOI: 10.1016/j.zool.2007.01.006
2007Egg tooth development in the snake
European Cells and Materials
Bandali, H. and Buchtova, M. and Richman, J.M. and Tucker, A.S.
2007Gene discovery in craniofacial development and disease - cashing in your chips
Clinical Genetics
Handrigan, G. R. and Buchtova, M. and Richman, J. M.
DOI: 10.1111/j.1399-0004.2007.00761.x
2007Embryonic development of Python sebae - I: Staging criteria and macroscopic skeletal morphogenesis of the head and limbs
Zoology
Boughner, Julia C. and Buchtova, Marcela and Fu, Katherine and Diewert, Virginia and Hallgrimsson, Benedikt and Richman, Joy M.
DOI: 10.1016/j.zool.2007.01.005
2007Reptilian evo-devo: Replacement tooth formation in the bearded dragon Pogona vitticeps
Journal of Morphology
Handrigan, Gregory R. and Buchtova, Marcela and Diewert, Virginia and Richman, Joy M.
2007An endogenous retinoic acid gradient is used to set up rostrocaudal upper beak pattern
Journal of Morphology
Bucluova, Marcela and Song, Yiping and Richman, Joy
2007Evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein CDCA4 (HEPP)
Gene
Bennetts, J. S. and Fowles, L. F. and Berkman, J. L. and van Bueren, K. L. and Richman, J. M. and Simpson, F. and Wicking, C.
DOI: 10.1016/j.gene.2006.01.027
2006Cell dissociation experiments reveal that positional information operates in the chicken frontonasal mass
Genesis
Kawakami, M. and Inoue, M. and Richman, J. M.
DOI: 10.1002/gene.20191
2006Comparative ontogeny and phylogeny of the upper jaw skeleton in amniotes
Developmental Dynamics
Richman, J. M. and Buchtova, M. and Boughner, J. C.
DOI: 10.1002/dvdy.20716
2006Retinoid signaling determines germ cell fate in mice
Science
Bowles, J. and Knight, D. and Smith, C. and Wilhelm, D. and Richman, J. and Mamiya, S. and Yashiro, K. and Chawengsaksophak, K. and Wilson, M. J. and Rossant, J. and Hamada, H. and Koopman, P.
DOI: 10.1126/science.1125691
2006Upper beak truncation in chicken embryos with the cleft primary palate mutation is due to an epithelial defect in the frontonasal mass
Developmental Dynamics
MacDonald, M.E. and Abbott, U.K. and Richman, J.M.
DOI: 10.1002/dvdy.20041
2004Control of retinoic acid synthesis and FGF expression in the nasal pit is required to pattern the craniofacial skeleton
Developmental Biology
Song, Y. and Hui, J.N. and Fu, K.K. and Richman, J.M.
DOI: 10.1016/j.ydbio.2004.08.035
2004A new origin for the maxillary jaw
Developmental Biology
Lee, S. H. and Bedard, O. and Buchtova, M. and Fu, K. and Richman, J. A.
DOI: 10.1016/j.ydbio.2004.08.045
2004About face: Signals and genes controlling jaw patterning and identity in vertebrates
BioEssays
Richman, J.M. and Lee, S.-H.
DOI: 10.1002/bies.10288
2003Endogenous bone morphogenetic proteins regulate outgrowth and epithelial survival during avian lip fusion
Development
Ashique, A.M. and Fu, K. and Richman, J.M.
2002Signalling via type IA and type IB bone morphogenetic protein receptors (BMPR) regulates intramembranous bone formation, chondrogenesis and feather formation in the chicken embryo
International Journal of Developmental Biology
Ashique, A.M. and Fu, K. and Richman, J.M.
2002Isolation and characterisation of the chick orthologue of the Opitz syndrome gene, Mid1, supports a conserved role in vertebrate development
International Journal of Developmental Biology
Richman, J.M. and Fu, K.K. and Cox, L.L. and Sibbons, J.P. and Cox, T.C.
2002Noggin and retinoic acid transform the identity of avian facial prominences
Nature
Lee, S.-H. and Fu, K.K. and Hui, J.N. and Richman, J.M.
DOI: 10.1038/414909a
2001Locally released retinoic acid repatterns the first branchial arch cartilages in vivo
Developmental Biology
Plant, M.R. and MacDonald, M.E. and Grad, L.I. and Ritchie, S.J. and Richman, J.M.
DOI: 10.1006/dbio.2000.9706
2000Expression of fibroblast growth factor receptors (FGFR1, FGFR2, FGFR3) in the developing head and face
Developmental Dynamics
Wilke, T.A. and Gubbels, S. and Schwartz, J. and Richman, J.M.
DOI: 10.1002/(SICI)1097-0177(199709)210:1<41::AID-AJA5>3.0.CO;2-1
1997Chicken transcription factor AP-2: Cloning, expression and its role in outgrowth of facial prominences and limb buds
Developmental Biology
Shen, H. and Wilke, T. and Ashique, A.M. and Narvey, M. and Zerucha, T. and Savino, E. and Williams, T. and Richman, J.M.
DOI: 10.1006/dbio.1997.8617
1997Epithelium is required for maintaining FGFR-2 expression levels in facial mesenchyme of the developing chick embryo
Developmental Dynamics
Matovinovic, E. and Richman, J.M.
1997Effect of fibroblast growth factors on outgrowth of facial mesenchyme
Developmental Biology
Richman, J.M. and Herbert, M. and Matovinovic, E. and Walin, J.
DOI: 10.1006/dbio.1997.8656
1997Craniofacial development: Knockout mice take one on the chin
Current Biology
Richman, J. and Mitchell, P.J.
1996Locally released retinoic acid leads to facial clefts in the chick embryo but does not alter the expression of receptors for fibroblast growth factor
Journal of Craniofacial Genetics and Developmental Biology
Richman, J.M. and Delgado, J.L.
1995Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes
Cell
Nasir, J. and Floresco, S.B. and O'Kusky, J.R. and Diewert, V.M. and Richman, J.M. and Zeisler, J. and Borowski, A. and Marth, J.D. and Phillips, A.G. and Hayden, M.R.
DOI: 10.1016/0092-8674(95)90542-1
1995Head Development: Craniofacial genetics makes headway
Current Biology
Richman, J.M.
DOI: 10.1016/S0960-9822(95)00068-6
1995The role of retinoids in normal and abnormal embryonic craniofacial morphogenesis
Critical Reviews in Oral Biology and Medicine
Richman, J.M.
1993Epithelial-mesenchymal interactions in the outgrowth of limb buds and facial primordia in chick embryos
Developmental Biology
Richman, J.M. and Tickle, C.
DOI: 10.1016/0012-1606(92)90069-S
1992Development of the spatial pattern of retinoic acid receptor-ß transcripts in embryonic chick facial primordia
Development
Rowe, A. and Richman, J.M. and Brickell, P.M.
1992Signals involved in patterning and morphogenesis of the embryonic face.
Progress in clinical and biological research
Richman, J.M. and Rowe, A. and Brickell, P.M.
1991Retinoic acid treatment alters the distribution of retinoic acid receptor-ß transcripts in the embryonic chick face
Development
Rowe, A. and Richman, J.M. and Brickell, P.M.
1991Differential growth of facial primordia in chick embryos: Responses of facial mesenchyme to basic fibroblast growth factor (bFGF) and serum in micromass culture
Development
Richman, J.M. and Crosby, Z.
1990Epithelia are interchangeable between facial primordia of chick embryos and morphogenesis is controlled by the mesenchyme
Developmental Biology
Richman, J.M. and Tickle, C.
DOI: 10.1016/0012-1606(89)90142-5
1989The fate of Meckel's cartilage chondrocytes in ocular culture
Developmental Biology
Richman, J.M. and Diewert, V.M.
DOI: 10.1016/0012-1606(88)90160-1
1988An immunofluorescence study of chondrogenesis in murine mandibular ectomesenchyme
Cell Differentiation
Richman, J.M. and Diewert, V.M.
DOI: 10.1016/0045-6039(87)90453-2
1987Tooth induction and temporal patterning in palatal epithelium of fetal mice
American Journal of Anatomy
Richman, J.M. and Kollar, E.J.
1986 - Research
-
Current Projects
My lab is the only two in Canada and one of few in the world that focuses on the patterning mechanisms in embryonic facial development. During my career I have worked on all stages of facial patterning from neural crest cells, to facial prominence formation and finally the differentiation of the skull. My main accomplishments are to develop the chicken as a model for studying the molecular controls of cleft lip and for understanding how jaw identity is established. In addition to work with chicken, I have worked with mouse and reptilian embryos. My training as a pediatric dentist feeds directly into the reptilian tooth replacement studies since we are adapting certain dental procedures to the gecko. I am making unique contributions to the biology of tooth replacement that cannot be studied in the mouse which only has one set of teeth.
Here are the topics I am currently investigating:
1) Rare diseases affecting craniofacial and limb development
2) Measuring developmental instability in the face using live imaging
3) Exploring the stem cells and molecules required for life-long tooth replacement in geckos
4) 3D morphometrics of human craniofacial and dental development in the middle trimester
5) Assessing the value of virtual health visits for dental consultationsGrantsCIHR – “Discovery of novel WNT signaling mechanisms from the study of human genetic disease in two animal models”. 2019- 2024
NSERC – “Reptilian Tooth and Jaw Development”. 2016-2024
NIH – “Development of the leopard gecko as a model to study in vivo tooth replacement”. 2017-2021
Honours & AwardsFellow of the Academy of Health Sciences 2020
Canadian Association for Dental Research National Dental Research Award 2020
Torin Halvorson and Hebah Hussaina awarded Vanier scholarships for immunotherapy and mental health research
BC Children’s Hospital Research Institute (BCCHR) is proud to announce that two of its outstanding research trainees, Torin Halvorson, an MD/PhD student working with the Levings research team, and Hebah Hussaina, a graduate research assistant in the Brussoni Lab, have been awarded the prestigious 2024 Vanier Canada Graduate Scholarship.
