Overview

As an academic pediatric cardiologist, I am interested in optimizing outcomes for all children with cardiovascular disease. My research program ranges from preventive cardiology – where we evaluate and promote physical activity in children with congenital and non-congenital cardiovascular disease – to interventional pediatric cardiology– where we are interested in optimizing outcomes of interventional cardiac catheterizations and pediatric cardiac surgery.

I currently serve as President of the Canadian Pediatric Cardiology Association and am also a member of the Canadian Hypertension Education Program, where I lead the development of the inaugural Guidelines for Blood Pressure Measurement, Diagnosis, and Assessment of Risk of Pediatric Hypertension.

Publications

Physical Activity and Sedentary Behavior in Children With Congenital Heart Disease.
Voss C, Duncombe SL, Dean PH, de Souza AM, Harris KC
DOI: 10.1161/jaha.116.004665
PubMed: 28264859
03/2017

Oscillometric and auscultatory blood pressure measurement methods in children: a systematic review and meta-analysis.
Duncombe SL, Voss C, Harris KC
DOI: 10.1097/hjh.0000000000001178
PubMed: 27870656
02/2017

A National Call to Action-Improving the Detection of Critical Congenital Heart Disease.
Harris KC
DOI: 10.1016/j.cjca.2016.11.015
PubMed: 28129863
02/2017

Outcomes of Radiofrequency Perforation for Pulmonary Atresia and Intact Ventricular Septum: A Single-Centre Experience.
Rathgeber S, Auld B, Duncombe S, Hosking MC, Harris KC
DOI: 10.1007/s00246-016-1498-0
PubMed: 27837307
01/2017

Hybrid stenting for left ventricular outflow tract obstruction in congenitally corrected transposition of the great arteries.
Rathgeber SL, Gandhi SK, Harris KC
PubMed: 27938457
12/2016

Validity of Commercial Activity Trackers in Children With Congenital Heart Disease.
Voss C, Gardner RF, Dean PH, Harris KC
DOI: 10.1016/j.cjca.2016.11.024
PubMed: 28347581
12/2016

Valvar aortico-ventricular tunnel: an insight into the development of the great arteries.
Maghrabi K, Gandhi S, Harris KC
PubMed: 27894369
11/2016

Hypertension Canada's 2016 Canadian Hypertension Education Program Guidelines for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension.
Leung AA, Nerenberg K, Daskalopoulou SS, McBrien K, Zarnke KB, Dasgupta K, Cloutier L, Gelfer M, Lamarre-Cliche M, Milot A, Bolli P, Tremblay G, McLean D, Tobe SW, Ruzicka M, Burns KD, Vallée M, Prasad GV, Lebel M, Feldman RD
DOI: 10.1016/j.cjca.2016.02.066
PubMed: 27118291
05/2016

Hypertension Canada's 2016 Canadian Hypertension Education Program Guidelines for Blood Pressure Measurement, Diagnosis, and Assessment of Risk of Pediatric Hypertension.
Harris KC, Benoit G, Dionne J, Feber J, Cloutier L, Zarnke KB, Padwal RS, Rabi DM, Fournier A, CHEP Guidelines Task Force
DOI: 10.1016/j.cjca.2016.02.075
PubMed: 27118292
05/2016

Peritoneal-pericardial communication in an adolescent on peritoneal dialysis.
Teoh CW, Nadel H, Armstrong K, Harris KC, White CT
DOI: 10.1007/s00467-015-3206-3
PubMed: 26386589
01/2016

The 2015 Canadian Hypertension Education Program recommendations for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertension.
Daskalopoulou SS, Rabi DM, Zarnke KB, Dasgupta K, Nerenberg K, Cloutier L, Gelfer M, Lamarre-Cliche M, Milot A, Bolli P, McKay DW, Tremblay G, McLean D, Tobe SW, Ruzicka M, Burns KD, Vallée M, Ramesh Prasad GV, Lebel M, Feldman RD
DOI: 10.1016/j.cjca.2015.02.016
PubMed: 25936483
05/2015

Obesity and arterial stiffness in children: systematic review and meta-analysis.
Cote AT, Phillips AA, Harris KC, Sandor GG, Panagiotopoulos C, Devlin AM
DOI: 10.1161/atvbaha.114.305062
PubMed: 25633314
04/2015

Should early extubation be the goal for children after congenital cardiac surgery?
Harris KC, Holowachuk S, Pitfield S, Sanatani S, Froese N, Potts JE, Gandhi SK
DOI: 10.1016/j.jtcvs.2014.06.093
PubMed: 25156467
12/2014

Childhood obesity, arterial stiffness, and prevalence and treatment of hypertension.
Armstrong KR, Cote AT, Devlin AM, Harris KC
DOI: 10.1007/s11936-014-0339-9
PubMed: 25248796
11/2014

Optical coherence tomography for the evaluation of asymmetric cardiac allograft vasculopathy in a child.
Greenway SC, Hosking M, Harris KC
DOI: 10.1111/petr.12303
PubMed: 24953969
09/2014

Feasibility of optical coherence tomography in children with Kawasaki disease and pediatric heart transplant recipients.
Harris KC, Manouzi A, Fung AY, De Souza A, Bezerra HG, Potts JE, Hosking MC
DOI: 10.1161/circimaging.113.001764
PubMed: 24874056
07/2014

Chylous pericardial effusion in granulomatosis with polyangiitis.
Larkins N, Harris KC, Morishita K, Matsell DG
DOI: 10.1111/nep.12262
PubMed: 24842790
06/2014

A prospective observational multicenter study of balloon angioplasty for the treatment of native and recurrent coarctation of the aorta.
Harris KC, Du W, Cowley CG, Forbes TJ, Kim DW, Congenital Cardiac Intervention Study Consortium (CCISC)
DOI: 10.1002/ccd.25284
PubMed: 24917074
06/2014

Subtotal obstruction of a tube fenestrated fontan conduit.
Moodley S, Gandhi SK, Harris KC
DOI: 10.1136/heartjnl-2013-304377
PubMed: 24192978
03/2014

Childhood obesity and cardiovascular dysfunction.
Cote AT, Harris KC, Panagiotopoulos C, Sandor GG, Devlin AM
DOI: 10.1016/j.jacc.2013.07.042
PubMed: 23954339
10/2013

Single-ventricle anatomy predicts delayed microstructural brain development.
Sethi V, Tabbutt S, Dimitropoulos A, Harris KC, Chau V, Poskitt K, Campbell A, Azakie A, Xu D, Barkovich AJ, Miller SP, McQuillen PS
DOI: 10.1038/pr.2013.29
PubMed: 23407116
05/2013

Biophysical properties of the aorta and left ventricle and exercise capacity in obese children.
Harris KC, Al Saloos HA, De Souza AM, Sanatani S, Hinchliffe M, Potts JE, Sandor GG
DOI: 10.1016/j.amjcard.2012.05.019
PubMed: 22728002
09/2012

Neuroblastoma masquerading as supraventricular tachycardia: a case of super sinus tachycardia.
Harris KC, Retallack JE, Sanatani S
DOI: 10.1136/archdischild-2011-301327
PubMed: 22267393
06/2012

An unusual case of cyanosis in right ventricular dysplasia in a child.
Dhillon SS, Duncan WJ, Harris KC, Sandor GG
DOI: 10.1016/j.jacc.2011.07.057
PubMed: 22361406
02/2012

Images in clinical medicine. Thrombosis of a mechanical mitral valve.
Harris KC, Campbell AI
DOI: 10.1056/nejmicm1100131
PubMed: 22168664
12/2011

Persistent fever in an infant: incomplete Kawasaki disease.
Harris KC, Hosking MC
DOI: 10.1503/cmaj.110032
PubMed: 21896689
11/2011

Economic evaluation of palivizumab in children with congenital heart disease: a Canadian perspective.
Harris KC, Anis AH, Crosby MC, Cender LM, Potts JE, Human DG
DOI: 10.1016/j.cjca.2010.12.064
PubMed: 21664100
2011

Effect of school-based physical activity interventions on body mass index in children: a meta-analysis.
Harris KC, Kuramoto LK, Schulzer M, Retallack JE
DOI: 10.1503/cmaj.080966
PubMed: 19332753
03/2009

Right ventricular outflow tract tachycardia in children.
Harris KC, Potts JE, Fournier A, Gross GJ, Kantoch MJ, Cote JM, Sanatani S
DOI: 10.1016/j.jpeds.2006.08.076
PubMed: 17137900
12/2006

Research

Interventional Pediatric Cardiology
Through collaborations with cardiac surgery and cardiac anesthesia we aim to optimize care delivery before, during and after interventional procedures for children with congenital heart disease and cardiac transplant recipients. We are currently evaluating the clinical impact of a new high resolution intravascular imaging technique called ‘Optical Coherence Tomography (OCT)’. We have successfully established an International Pediatric OCT Registry and the Children’s Heart Centre serves as the lead centre, and hosts both the core imaging laboratory and data coordinating centre for evaluating this exciting new imaging modality in children and adolescents.

Cardiovascular outcomes
I am interested in the childhood origins of non-congenital cardiovascular disease. We previously found that at-risk children – for example, individuals with obesity or congenital heart disease – have significant cardiovascular changes already in childhood, such as aortic stiffness and elevated blood pressure. We are presently conducting interventional and longitudinal observational studies to evaluate the impact of physical activity and exercise on cardiovascular health in these children.

Vascular health is also a concern in children who have had Kawasaki disease. I am actively involved in evaluating the coronary artery changes in children with Kawasaki disease. I serve as the site PI for a North American collaboration evaluating the long-term outcomes of coronary aneurysms in children with KD.

Preventive Cardiology
Physical activity is critical to optimize long-term cardiovascular health in children with congenital and non-congenital heart disease. We use state-of-the-art measurement tools and new technologies, such as commercial activity trackers, to better understand and promote physical activity levels in our patients. My research in this area also investigates perceived barriers and facilitators for physical activity in these children and their parents.

Honours & Awards

Resident Research Mentor Award, Department of Pediatrics, BC Children’s Hospital, University of British Columbia (2015)

Young Investigator Award, Canadian Cardiovascular Society (2013)

UBC Fellow Research Award, Department of Pediatrics, BC Children’s Hospital, University of British Columbia (2011)

Research Group Members

Christine Voss
Adrija Chakrabarti, Undergraduate Student
Erica Bennett
Sabine Laguë
Nicole Hemphill, Research Assistant
Jimmy Lopez
Monica Lai
Mimi Kuan, Master's Student
Ana Pozas