My research interests are in the area of Allergy and Clinical Immunology. The immune system plays a critical role in protecting hosts from infection. Primary immunodeficiency encompasses a group of disorders whereby parts of the immune system may be defective or missing, often resulting in severe, invasive or recurrent infections, autoimmunity and malignancy. The genetic makeup of an individual and the response of the immune system to external environmental factors can result in allergic disorders and disease. There is a strong relationship between conditions such as asthma, food allergy and atopic dermatitis - all of which have an underlying immunological basis. My research aims to study these disorders and apply knowledge translation strategies to empower patients, families and their physicians.


Supervised epinephrine autoinjector administration in a cohort of children with anaphylaxis during oral food challenges (OFCs)
Journal of Allergy and Clinical Immunology
Lianne Soller and Timothy Teoh and Ingrid Baerg and Tracy Gonzalez and Tiffany Wong and Kyla J. Hildebrand and Edmond S. Chan
DOI: 10.1016/j.jaci.2017.12.800

Interstitial lung disease in infancy: an unusual presentation of CD40 ligand deficiency
LymphoSign Journal
Victoria Elizabeth Cook and Connie L Yang and Alexia Dabadie and Joanne Luider and Kyla Jade Hildebrand and Anne K Junker and Stuart Turvey
DOI: 10.14785/lymphosign-2017-0003

Case 3: Persistent Fever in an 8-month-old Boy
Pediatrics in Review
Megan Kilvert and Ashley Roberts and Kyla J. Hildebrand
DOI: 10.1542/pir.2015-0145

Many Children Referred to a Tertiary Care Pediatric Allergy Clinic Do Not Have an Allergy
Journal of Allergy and Clinical Immunology
Victoria E. Cook and Jordan Yeo and Christopher Mill and Kyla Hildebrand and Elodie Portales-Casamar and Edmond S. Chan
DOI: 10.1016/j.jaci.2016.12.134

Determinants of Quality of life (QOL) Among Children Undergoing Oral Food Challenge (OFC) in Canada
Journal of Allergy and Clinical Immunology
Lianne Soller and Christopher Mill and Tiffany Wong and Ingrid Baerg and Tracy Gonzalez and Timothy Teoh and Kyla Hildebrand and Edmond S. Chan
DOI: 10.1016/j.jaci.2016.12.137

Primum non nocere—first do no harm. And then feed peanut
Allergy, Asthma & Clinical Immunology
Kyla Jade Hildebrand and Elissa Michele Abrams and Timothy K. Vander Leek and Julia Elizabeth Mainwaring Upton and Douglas P. Mack and Linda Kirste and Christine McCusker and Sandeep Kapur
DOI: 10.1186/s13223-017-0180-2

Mobile health applications in clinical practice: pearls, pitfalls, and key considerations
Annals of Allergy, Asthma & Immunology
Victoria E. Cook and Anne K. Ellis and Kyla J. Hildebrand
DOI: 10.1016/j.anai.2016.01.012

Impact of supervised epinephrine autoinjector administration during food challenges on parent confidence
Annals of Allergy, Asthma & Immunology
Timothy Teoh and Christopher Mill and Tiffany Wong and Ingrid Baerg and Angela Alexander and Kyla J. Hildebrand and John Dean and Boris Kuzeljevic and Edmond S. Chan
DOI: 10.1016/j.anai.2016.02.020

IRAK-4 deficiency as a cause for familial fatal invasive infection by Streptococcus pneumoniae
Clinical Immunology
Serge Grazioli and Sara J. Hamilton and Margaret L. McKinnon and Kate L. Del Bel and Linda Hoang and Victoria E. Cook and Kyla J. Hildebrand and Anne K. Junker and Stuart E. Turvey
DOI: 10.1016/j.clim.2015.12.007

Limitation of TREC-based newborn screening for ZAP70 Severe Combined Immunodeficiency
Clinical Immunology
Serge Grazioli and Mary Bennett and Kyla J. Hildebrand and Hilary Vallance and Stuart E. Turvey and Anne K. Junker
DOI: 10.1016/j.clim.2014.04.015

Rifampin Hypersensitivity in a 2-year-old Child With Successful Rapid Oral Desensitization
The Pediatric Infectious Disease Journal
Kyla J. Hildebrand and Adelle Atkinson and Ian Kitai
DOI: 10.1097/inf.0000000000000295

Epinephrine auto injector administration by parents or patients for anaphylaxis during supervised oral food challenges and assessment of confidence
Allergy, Asthma & Clinical Immunology
Ingrid Baerg and Angela Alexander and Tiffany Wong and Timothy Teoh and Kyla Hildebrand and Sara Leo and Joanne Yeung and John Dean and Edmond Chan
DOI: 10.1186/1710-1492-10-s2-a2

Human primary immunodeficiencies causing defects in innate immunity
Current Opinion in Allergy and Clinical Immunology
Tiffany Wong and Joanne Yeung and Kyla J. Hildebrand and Anne K. Junker and Stuart E. Turvey
DOI: 10.1097/aci.0000000000000010

Vasculitis masquerading as drug allergy: thinking outside the ‘adult’ box of possible diagnoses
Allergy, Asthma & Clinical Immunology
Marie-Elodie Sarre-Annweiler and Mariamma Joseph and Kyla J Hildebrand
DOI: 10.1186/1710-1492-8-s1-a15

Rifampin hypersensitivity in a two year-old child with successful rapid oral desensitization
Allergy, Asthma & Clinical Immunology
KJ Hildebrand and D Hummel
DOI: 10.1186/1710-1492-6-s1-p22


Epinephrine Autoinjector Study
Caregivers and patients in Pediatric Allergy Clinic often report that they are fearful of using an epinephrine autoinjector despite receiving education on indications for use and technique. Given that intramuscular epinephrine is the only medication that can reverse a potentially severe allergic reaction, it is very important that patients and caregivers possess not only the knowledge and ability to use epinephrine autoinjectors, but also have the confidence to administer the medication when clinically indicated. The goal of the Epinephrine Autoinjector study is to assess the impact of self or caregiver-administrated epinephrine in a medically supervised setting on the confidence of patient and/or caregivers for future use of epinephrine autoinjector.

Certified Asthma Educator (CAE) Anaphylaxis Counseling Study
Several of my research projects involve studying the relationship between asthma, allergy and anaphylaxis. Many patients with severe asthma who require admission to intensive care units or repeated hospital admissions have underlying allergic triggers (environmental or food allergy). Poorly controlled asthma is a significant risk factor for anaphylaxis in this patient population. I am assessing the frequency of anaphylaxis counseling performed by a group of CAEs at BC Children’s Hospital and the outcomes associated with this counseling intervention. For patients living in remote areas of British Columbia, there is greater accessibility to CAEs in comparison to pediatric asthma/allergy specialists. There may be a role for curricular innovation to the CAE training programs across Canada to better serve this at-risk patient population.

The CHILD study
this study is a multicenter, multidisciplinary, longitudinal, population-based cohort study of 5000 children. The aim of the study is to test multiple hypotheses within the theme that specific environmental exposures along with genetic and immunological determinants, lead to pathophysiological allergic responses, and that clinical outcomes including asthma may be further modified by lung growth, hormonal and metabolic influences and psychosocial environment. Children were recruited from 4 cities in Canada, including Vancouver and are being followed prospectively.

Honours & Awards

Royal College of Physicians and Surgeons Canada Fellowship for Studies in Medical Education (2010)