Overview

My research interests are in the area of Allergy and Clinical Immunology. The immune system plays a critical role in protecting hosts from infection. Primary immunodeficiency encompasses a group of disorders whereby parts of the immune system may be defective or missing, often resulting in severe, invasive or recurrent infections, autoimmunity and malignancy. The genetic makeup of an individual and the response of the immune system to external environmental factors can result in allergic disorders and disease. There is a strong relationship between conditions such as asthma, food allergy and atopic dermatitis - all of which have an underlying immunological basis. My research aims to study these disorders and apply knowledge translation strategies to empower patients, families and their physicians.

Publications

Supervised epinephrine autoinjector administration in a cohort of children with anaphylaxis during oral food challenges (OFCs)
Journal of Allergy and Clinical Immunology
Lianne Soller, Timothy Teoh, Ingrid Baerg, Tracy Gonzalez, Tiffany Wong, Kyla J. Hildebrand, Edmond S. Chan
DOI: 10.1016/j.jaci.2017.12.800
02/2018

Interstitial lung disease in infancy: an unusual presentation of CD40 ligand deficiency
LymphoSign Journal
Victoria Elizabeth Cook, Connie L Yang, Alexia Dabadie, Joanne Luider, Kyla Jade Hildebrand, Anne K Junker, Stuart Turvey
DOI: 10.14785/lymphosign-2017-0003
06/2017

Case 3: Persistent Fever in an 8-month-old Boy
Pediatrics in Review
Megan Kilvert, Ashley Roberts, Kyla J. Hildebrand
DOI: 10.1542/pir.2015-0145
03/2017

Many Children Referred to a Tertiary Care Pediatric Allergy Clinic Do Not Have an Allergy
Journal of Allergy and Clinical Immunology
Victoria E. Cook, Jordan Yeo, Christopher Mill, Kyla Hildebrand, Elodie Portales-Casamar, Edmond S. Chan
DOI: 10.1016/j.jaci.2016.12.134
02/2017

Determinants of Quality of life (QOL) Among Children Undergoing Oral Food Challenge (OFC) in Canada
Journal of Allergy and Clinical Immunology
Lianne Soller, Christopher Mill, Tiffany Wong, Ingrid Baerg, Tracy Gonzalez, Timothy Teoh, Kyla Hildebrand, Edmond S. Chan
DOI: 10.1016/j.jaci.2016.12.137
02/2017

Primum non nocere—first do no harm. And then feed peanut
Allergy, Asthma & Clinical Immunology
Kyla Jade Hildebrand, Elissa Michele Abrams, Timothy K. Vander Leek, Julia Elizabeth Mainwaring Upton, Douglas P. Mack, Linda Kirste, Christine McCusker, Sandeep Kapur
DOI: 10.1186/s13223-017-0180-2
02/2017

Mobile health applications in clinical practice: pearls, pitfalls, and key considerations
Annals of Allergy, Asthma & Immunology
Victoria E. Cook, Anne K. Ellis, Kyla J. Hildebrand
DOI: 10.1016/j.anai.2016.01.012
08/2016

Impact of supervised epinephrine autoinjector administration during food challenges on parent confidence
Annals of Allergy, Asthma & Immunology
Timothy Teoh, Christopher Mill, Tiffany Wong, Ingrid Baerg, Angela Alexander, Kyla J. Hildebrand, John Dean, Boris Kuzeljevic, Edmond S. Chan
DOI: 10.1016/j.anai.2016.02.020
05/2016

IRAK-4 deficiency as a cause for familial fatal invasive infection by Streptococcus pneumoniae
Clinical Immunology
Serge Grazioli, Sara J. Hamilton, Margaret L. McKinnon, Kate L. Del Bel, Linda Hoang, Victoria E. Cook, Kyla J. Hildebrand, Anne K. Junker, Stuart E. Turvey
DOI: 10.1016/j.clim.2015.12.007
02/2016

Rifampin Hypersensitivity in a 2-year-old Child With Successful Rapid Oral Desensitization
The Pediatric Infectious Disease Journal
Kyla J. Hildebrand, Adelle Atkinson, Ian Kitai
DOI: 10.1097/inf.0000000000000295
07/2014

Limitation of TREC-based newborn screening for ZAP70 Severe Combined Immunodeficiency
Clinical Immunology
Serge Grazioli, Mary Bennett, Kyla J. Hildebrand, Hilary Vallance, Stuart E. Turvey, Anne K. Junker
DOI: 10.1016/j.clim.2014.04.015
07/2014

Epinephrine auto injector administration by parents or patients for anaphylaxis during supervised oral food challenges and assessment of confidence
Allergy, Asthma & Clinical Immunology
Ingrid Baerg, Angela Alexander, Tiffany Wong, Timothy Teoh, Kyla Hildebrand, Sara Leo, Joanne Yeung, John Dean, Edmond Chan
DOI: 10.1186/1710-1492-10-s2-a2
2014

Human primary immunodeficiencies causing defects in innate immunity
Current Opinion in Allergy and Clinical Immunology
Tiffany Wong, Joanne Yeung, Kyla J. Hildebrand, Anne K. Junker, Stuart E. Turvey
DOI: 10.1097/aci.0000000000000010
2013

Vasculitis masquerading as drug allergy: thinking outside the ‘adult’ box of possible diagnoses
Allergy, Asthma & Clinical Immunology
Marie-Elodie Sarre-Annweiler, Mariamma Joseph, Kyla J Hildebrand
DOI: 10.1186/1710-1492-8-s1-a15
2012

Rifampin hypersensitivity in a two year-old child with successful rapid oral desensitization
Allergy, Asthma & Clinical Immunology
KJ Hildebrand, D Hummel
DOI: 10.1186/1710-1492-6-s1-p22
2010

Research

Epinephrine Autoinjector Study
Caregivers and patients in Pediatric Allergy Clinic often report that they are fearful of using an epinephrine autoinjector despite receiving education on indications for use and technique. Given that intramuscular epinephrine is the only medication that can reverse a potentially severe allergic reaction, it is very important that patients and caregivers possess not only the knowledge and ability to use epinephrine autoinjectors, but also have the confidence to administer the medication when clinically indicated. The goal of the Epinephrine Autoinjector study is to assess the impact of self or caregiver-administrated epinephrine in a medically supervised setting on the confidence of patient and/or caregivers for future use of epinephrine autoinjector.

Certified Asthma Educator (CAE) Anaphylaxis Counseling Study
Several of my research projects involve studying the relationship between asthma, allergy and anaphylaxis. Many patients with severe asthma who require admission to intensive care units or repeated hospital admissions have underlying allergic triggers (environmental or food allergy). Poorly controlled asthma is a significant risk factor for anaphylaxis in this patient population. I am assessing the frequency of anaphylaxis counseling performed by a group of CAEs at BC Children’s Hospital and the outcomes associated with this counseling intervention. For patients living in remote areas of British Columbia, there is greater accessibility to CAEs in comparison to pediatric asthma/allergy specialists. There may be a role for curricular innovation to the CAE training programs across Canada to better serve this at-risk patient population.

The CHILD study
this study is a multicenter, multidisciplinary, longitudinal, population-based cohort study of 5000 children. The aim of the study is to test multiple hypotheses within the theme that specific environmental exposures along with genetic and immunological determinants, lead to pathophysiological allergic responses, and that clinical outcomes including asthma may be further modified by lung growth, hormonal and metabolic influences and psychosocial environment. Children were recruited from 4 cities in Canada, including Vancouver and are being followed prospectively.

Honours & Awards

Royal College of Physicians and Surgeons Canada Fellowship for Studies in Medical Education (2010)