Overview

There is increasing evidence to suggest that intestinal inflammation affects the organization and function of the intestinal nervous system, which controls how our intestine works. As a result, changes in nerve function may alter how the inestine works, worsen inflammation and aggravate the symptoms in IBD. In our studies we are examining the nerve-intestinal lining responses to inflammation in animal models if IBD and in our children with IBD. We will determine what nerve changes occur in assoications with intestinal inflammation, how these changes affectr the function of the intestinal lining cells and whether these changes persist. We will also examine the potential benfit of probiotics (living non-harmful bacteria).

We are also examining the effects of maternal dietary fat on intestinal lining cells (which protect the host from harmful dietary agents and infectious organisms) and on the intestinal immune response in young offspring.

Publications

Frontline defenders: Goblet cell mediators dictate host-microbe interactions in the intestinal tract during health and disease.
American journal of physiology. Gastrointestinal and liver physiology
Allaire JM, Morampudi V, Crowley SM, Stahl M, Yu H, Bhullar K, Knodler LA, Bressler B, Jacobson K, Vallance BA
DOI: 10.1152/ajpgi.00181.2017
PubMed: 29122749
11/2017

Concomitant Therapy with Immunomodulator Enhances Infliximab Durability in Pediatric Inflammatory Bowel Disease
Inflammatory Bowel Diseases
Julianna Cheng, Zachary Hamilton, Matthew Smyth, Collin Barker, David Israel, Kevan Jacobson
DOI: 10.1097/mib.0000000000001212
10/2017

Rural and Urban Residence During Early Life is Associated with Risk of Inflammatory Bowel Disease: A Population-Based Inception and Birth Cohort Study
The American Journal of Gastroenterology
DOI: 10.1038/ajg.2017.208
PubMed: 28741616
07/2017

Trends in Epidemiology of Pediatric Inflammatory Bowel Disease in Canada: Distributed Network Analysis of Multiple Population-Based Provincial Health Administrative Databases.
The American journal of gastroenterology
Benchimol EI, Bernstein CN, Bitton A, Carroll MW, Singh H, Otley AR, Vutcovici M, El-Matary W, Nguyen GC, Griffiths AM, Mack DR, Jacobson K, Kaplan GG
DOI: 10.1038/ajg.2017.97
PubMed: 28417994
07/2017

Repression of Salmonella host cell invasion by aromatic small molecules from the human fecal metabolome.
Applied and environmental microbiology
Peixoto RJM, Alves ES, Wang M, Ferreira RBR, Granato A, Han J, Gill H, Jacobson K, Lobo LA, Domingues RMCP, Borchers CH, Davies JE, Finlay BB, Antunes LCM
DOI: 10.1128/aem.01148-17
PubMed: 28754707
07/2017

Long-term Outcomes of Infliximab use for Pediatric Crohn's disease A Canadian Multicenter Clinical Practice Experience
Journal of Pediatric Gastroenterology and Nutrition
Jennifer C. deBruyn, Kevan Jacobson, Wael El-Matary, Matthew Carroll, Eytan Wine, Iwona Wrobel, Mariel Van Woudenberg, Hien Q. Huynh
DOI: 10.1097/mpg.0000000000001672
06/2017

Ulcerative Colitis-Associated Escherichia Coli Colonize the Intestinal Mucosa of Susceptible Host and Promote Colitis via Hemolysin Production
Gastroenterology
Hengameh Chloé Mirsepasi-Lauridsen, Hyungjun Yang, Else Bosman, Carsten Struve, Hongbing Yu, Xiujuan Wu, Caixia Ma, Abbas Fotovati, Andreas M. Petersen, Kevan Jacobson, Karen A. Krogfelt, Bruce Vallance
DOI: 10.1016/s0016-5085(17)32838-x
04/2017

The Prevalence and Predictors of Anti-TNF Failure in a Population based Sample of Persons with IBD
Gastroenterology
Laura E. Targownik, Charles N. Bernstein, Harminder Singh, Aruni Tennakoon, Stella leung, Zoann Nugent, Lisa Lix, Kevan Jacobson, Juan-Nicolas Pena-Sanchez, Gilaad Kaplan
DOI: 10.1016/s0016-5085(17)31463-4
04/2017

Capsule Endoscopy Complements Magnetic Resonance Enterography and Ileo-Colonoscopy in the Evaluation of Suspected Small Bowel Crohn’s Disease in Pediatric Patients
Gastroenterology
David O. Prichard, Zachary Hamilton, Thomas Savage, Matthew Smyth, Carlie Penner, Alam Lakhani, Matthew Carroll, Ahmed A. Alsarkhy, Daniel Lemberg, Robert A. Enns, Robert J. Prosser, Daniel Jamieson, Kevan Jacobson
DOI: 10.1016/s0016-5085(17)32196-0
04/2017

Milk Fat Globule Membrane Supplementation in Formula Modulates the Neonatal Gut Microbiome and Normalizes Intestinal Development.
Scientific reports
Bhinder G, Allaire JM, Garcia C, Lau JT, Chan JM, Ryz NR, Bosman ES, Graef FA, Crowley SM, Celiberto LS, Berkmann JC, Dyer RA, Jacobson K, Vallance BA
DOI: 10.1038/srep45274
PubMed: 28349941
03/2017

Tricellular Tight Junction Protein Tricellulin Is Targeted by the Enteropathogenic Escherichia coli Effector EspG1, Leading to Epithelial Barrier Disruption.
Infection and immunity
Morampudi V, Graef FA, Stahl M, Dalwadi U, Conlin VS, Huang T, Vallance BA, Yu HB, Jacobson K
DOI: 10.1128/iai.00700-16
PubMed: 27795363
01/2017

Transition clinic attendance is associated with improved beliefs and attitudes toward medicine in patients with inflammatory bowel disease
World Journal of Gastroenterology
Nancy Fu, Kevan Jacobson, Andrew Round, Kathi Evans, Hong Qian, Brian Bressler
DOI: 10.3748/wjg.v23.i29.5405
2017

Allied Health Professional Support in Pediatric Inflammatory Bowel Disease: A Survey from the Canadian Children Inflammatory Bowel Disease Network—A Joint Partnership of CIHR and the CH.I.L.D. Foundation
Canadian Journal of Gastroenterology and Hepatology
Wael El-Matary, Eric I. Benchimol, David Mack, Hien Q. Huynh, Jeff Critch, Anthony Otley, Colette Deslandres, Kevan Jacobson, Jennifer deBruyn, Matthew W. Carroll, Eytan Wine, Johan Van Limbergen, Mary Sherlock, Kevin Bax, Sally Lawrence, Ernest Seidman, Robert Issenman, Thomas D. Walters, Peter Church, Anne M. Griffiths
DOI: 10.1155/2017/3676474
2017

Pneumocystis jirovecii Pneumonia in Pediatric Inflammatory Bowel Disease: A Case Report and Literature Review.
Frontiers in pediatrics
Lawrence SJ, Sadarangani M, Jacobson K
DOI: 10.3389/fped.2017.00161
PubMed: 28791279
2017

Association of host genome with intestinal microbial composition in a large healthy cohort
Nature Genetics
Williams Turpin, GEM Project Research Consortium, Osvaldo Espin-Garcia, Wei Xu, Mark S Silverberg, David Kevans, Michelle I Smith, David S Guttman, Anne Griffiths, Remo Panaccione, Anthony Otley, Lizhen Xu, Konstantin Shestopaloff, Gabriel Moreno-Hagelsieb, Andrew D Paterson, Kenneth Croitoru
DOI: 10.1038/ng.3693
10/2016

The goblet cell-derived mediator RELM-ß drives spontaneous colitis in Muc2-deficient mice by promoting commensal microbial dysbiosis.
Mucosal Immunology
Morampudi V, Dalwadi U, Bhinder G, Sham HP, Gill SK, Chan J, Bergstrom KS, Huang T, Ma C, Jacobson K, Gibson DL, Vallance BA
DOI: 10.1038/mi.2015.140
PubMed: 26813339
09/2016

Activity of SHIP, Which Prevents Expression of Interleukin 1ß, Is Reduced in Patients With Crohn's Disease.
Gastroenterology
Ngoh EN, Weisser SB, Lo Y, Kozicky LK, Jen R, Brugger HK, Menzies SC, McLarren KW, Nackiewicz D, van Rooijen N, Jacobson K, Ehses JA, Turvey SE, Sly LM
DOI: 10.1053/j.gastro.2015.09.049
PubMed: 26481854
02/2016

Pediatric Inflammatory Bowel Disease Among South Asians Living in British Columbia, CanadaA Distinct Clinical Phenotype
Inflammatory Bowel Diseases
Matthew W. Carroll, Zachary Hamilton, Hira Gill, Jonathan Simkin, Matthew Smyth, Victor Espinosa, Brian Bressler, Kevan Jacobson
DOI: 10.1097/mib.0000000000000651
02/2016

Dietary vitamin D3 deficiency alters intestinal mucosal defense and increases susceptibility to Citrobacter rodentium-induced colitis.
American journal of physiology. Gastrointestinal and liver physiology
Ryz NR, Lochner A, Bhullar K, Ma C, Huang T, Bhinder G, Bosman E, Wu X, Innis SM, Jacobson K, Vallance BA
DOI: 10.1152/ajpgi.00006.2015
PubMed: 26336925
11/2015

The Crohn's disease-associated polymorphism in ATG16L1 (rs2241880) reduces SHIP gene expression and activity in human subjects.
Genes and immunity
Ngoh EN, Brugger HK, Monajemi M, Menzies SC, Hirschfeld AF, Del Bel KL, Jacobson K, Lavoie PM, Turvey SE, Sly LM
DOI: 10.1038/gene.2015.30
PubMed: 26226011
10/2015

Mo1791 Ulcerative Colitis-Associated Escherichia coli Colonize the Ileum and Cecum of Infected Mice by Adhering to the Intestinal Epithelium
Gastroenterology
Hengameh Chloé Lauridsen, Hyungjun Yang, Else Bosman, Hongbing Yu, Xiujuan Wu, Caixia Ma, Carsten Struve, Andreas M. Petersen, Karen A. Krogfelt, Kevan Jacobson, Bruce Vallance
DOI: 10.1016/s0016-5085(15)32421-5
04/2015

Vasoactive intestinal peptide prevents PKCe-induced intestinal epithelial barrier disruption during EPEC infection.
American journal of physiology. Gastrointestinal and liver physiology
Morampudi V, Conlin VS, Dalwadi U, Wu X, Marshall KC, Nguyen C, Vallance BA, Jacobson K
DOI: 10.1152/ajpgi.00195.2014
PubMed: 25501546
03/2015

Maternal exposure to fish oil primes offspring to harbor intestinal pathobionts associated with altered immune cell balance
Gut Microbes
DL Gibson, SK Gill, K Brown, N Tasnim, S Ghosh, S Innis, K Jacobson
DOI: 10.1080/19490976.2014.997610
01/2015

Treatment Profile of Pediatric Inflammatory Bowel Disease in Saudi Arabia: Issues in Treatment Adherence
Advances in Pharmacology and Pharmacy
Mohammed Hasosah, Mohammed El Mouzan, Omar Saadah, Khalid Al-Saleem, Abdulrahman Al-Hussaini, Ali Al Mehaidib, Badr Al Saleem, Khalid Alquair, Kevan Jacobson
DOI: 10.13189/app.2015.030402
2015

Vasoactive intestinal polypeptide promotes intestinal barrier homeostasis and protection against colitis in mice.
PloS one
Wu X, Conlin VS, Morampudi V, Ryz NR, Nasser Y, Bhinder G, Bergstrom KS, Yu HB, Waterhouse CC, Buchan AM, Popescu OE, Gibson WT, Waschek JA, Jacobson K
DOI: 10.1371/journal.pone.0125225
PubMed: 25932952
2015

P-057A: Detecting inflammation in pediatric inflammatory bowel disease: the role of fecal calprotectin and its impact on management
Journal of Crohn's and Colitis
A.J. Foster, K. Jacobson
DOI: 10.1016/s1873-9946(14)50074-8
09/2014

P-067: C reactive protein as a predictor of response to infliximab in pediatric Crohn’s disease
Journal of Crohn's and Colitis
A. Al-Sahafi, K. Jacobson, M. Smyth
DOI: 10.1016/s1873-9946(14)50084-0
09/2014

Antivirulence activity of the human gut metabolome.
mBio
Antunes LC, McDonald JA, Schroeter K, Carlucci C, Ferreira RB, Wang M, Yurist-Doutsch S, Hira G, Jacobson K, Davies J, Allen-Vercoe E, Finlay BB
DOI: 10.1128/mbio.01183-14
PubMed: 25073640
07/2014

Intestinal Epithelium-Specific MyD88 Signaling Impacts Host Susceptibility to Infectious Colitis by Promoting Protective Goblet Cell and Antimicrobial Responses
Infection and Immunity
Ganive Bhinder, Martin Stahl, Ho Pan Sham, Shauna M. Crowley, Vijay Morampudi, Udit Dalwadi, Caixia Ma, Kevan Jacobson, Bruce A. Vallance
DOI: 10.1128/iai.02045-14
06/2014

Tu1195 The Influence of Adolescent Transition Clinics on the Attitudes and Beliefs in Medicine in Patients With Inflammatory Bowel Disease
Gastroenterology
Nancy Fu, Kevan Jacobson, Andrew M. Round, Kathi Evans, Hong Qian, Brian Bressler
DOI: 10.1016/s0016-5085(14)62816-x
05/2014

25-Hydroxyvitamin D concentrations in children with Crohn's disease supplemented with either 2000 or 400 IU daily for 6 months: a randomized controlled study.
The Journal of pediatrics
Wingate KE, Jacobson K, Issenman R, Carroll M, Barker C, Israel D, Brill H, Weiler H, Barr SI, Li W, Lyon MR, Green TJ
DOI: 10.1016/j.jpeds.2013.11.071
PubMed: 24423431
04/2014

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
Journal of Visualized Experiments
Vijay Morampudi, Ganive Bhinder, Xiujuan Wu, Chuanbin Dai, Ho Pan Sham, Bruce A. Vallance, Kevan Jacobson
DOI: 10.3791/51297
02/2014

Role of Omega-6 and Omega-3 Fatty Acids in Inflammatory Bowel Disease
Pharma-Nutrition
Kevan Jacobson and Philip C. Calder
DOI: 10.1007/978-3-319-06151-1_5
2014

Attainment of Steroid-Free Clinical Remission and Normal Growth Among Canadian Children with Inflammatory Bowel Disease
Inflammatory Bowel Diseases
Walters Thomas and Benchimol Eric and Jacobson Kevan and El-Matary Wael and Deslandres Colette and Huynh Hien and Church Peter and Carroll Matthew and Wine Eytan and Mack David and Griffiths Anne
DOI: 10.1097/01.mib.0000456870.74875.ed
2014

Prevalence and Risk Factors ofHelicobacter pyloriInfection in Saudi Children: A Three-Year Prospective Controlled Study
Helicobacter
Mohammed Hasosah, Mohammed Satti, Amir Shehzad, Ashraf Alsahafi, Ghassan Sukkar, Abdullah Alzaben, Areej Sunaid, Abdullah Ahmed, Sami AlThubiti, Areej Mufti, Kevan Jacobson
DOI: 10.1111/hel.12172
2014

Pediatric inflammatory bowel disease in the western region of Saudi Arabia. A retrospective analysis.
Saudi Medical Journal
Hasosah MY, Sukkar GA, Alsahafi AF, Kutbi SY, Alzabn AA, Jacobson K
PubMed: 23756933
06/2013

Dietary oils modify the host immune response and colonic tissue damage following Citrobacter rodentium infection in mice
American Journal of Physiology-Gastrointestinal and Liver Physiology
Azita Hekmatdoost, Xiujuan Wu, Vijay Morampudi, Sheila M. Innis, Kevan Jacobson
DOI: 10.1152/ajpgi.00292.2012
05/2013

Tu1744 The Relationship Between Common IBD-Associated Risk Alleles and Intestinal Permeability in a Cohort of Healthy First Degree Relatives of Individuals With Crohn's Disease
Gastroenterology
David Kevans, Karen Madsen, Mark S. Silverberg, Wei Xu, Konstantin Shestopaloff, Ummiye Venus Onay, Andrew D. Paterson, Anne M. Griffiths, Paul Moayyedi, Mark J. Ropeleski, Paul L. Beck, Charles N. Bernstein, Alain Bitton, Levinus A. Dieleman, David S. Guttman, Hien Q. Huynh, Kevan Jacobson, Gilaad G. Kaplan, John K. Marshall, Remo Panaccione, Ernest G. Seidman, Kathy Siminovitch, Denis Snider, Andrew Stadnyk, A. Hillary Steinhart, Michael Surette, Dan Turner, Bruce Vallance, Thomas D. Walters, Ken Croitoru
DOI: 10.1016/s0016-5085(13)63107-8
05/2013

Inflammatory Bowel Disease in the Pediatric South Asian Population of British Columbia, Canada: A Distinct and Severe Phenotype
Gastroenterology
Matthew W. Carroll and Hira S. Gill and Jonathan Simkin and Lee-Ann M. Carroll and Vered Pinsk and Victor M. Espinosa and Brian Bressler and Kevan Jacobson
DOI: 10.1016/s0016-5085(13)62389-6
05/2013

925e Altered intestinal epithelial homeostasis in mice with a target mutation in the gene encoding vasoactive intestinal peptide (VIP)
Gastroenterology
Xiujuan Wu, Kevan Jacobson
DOI: 10.1016/s0016-5085(13)60583-1
05/2013

The Citrobacter rodentium Mouse Model: Studying Pathogen and Host Contributions to Infectious Colitis
Journal of Visualized Experiments
Ganive Bhinder and Ho Pan Sham and Justin M. Chan and Vijay Morampudi and Kevan Jacobson and Bruce A. Vallance
DOI: 10.3791/50222
02/2013

Changing Incidence of Inflammatory Bowel Disease: Environmental Influences and Lessons Learnt from the South Asian Population
Frontiers in Pediatrics
Alice Foster, Kevan Jacobson
DOI: 10.3389/fped.2013.00034
2013

Clinical nutrition knowledge of gastroenterology fellows: is there anything omitted?
Acta medica Iranica
Eslamian G, Jacobson K, Hekmatdoost A
PubMed: 24338195
2013

Magnetic Resonance Imaging of the Perineum in Pediatric Patients with Inflammatory Bowel Disease
Canadian Journal of Gastroenterology
Douglas H Jamieson, Peter Shipman, Kevan Jacobson
DOI: 10.1155/2013/624141
2013

Active vitamin D (1,25-dihydroxyvitamin D3) increases host susceptibility to Citrobacter rodentium by suppressing mucosal Th17 responses.
American journal of physiology. Gastrointestinal and liver physiology
Ryz NR, Patterson SJ, Zhang Y, Ma C, Huang T, Bhinder G, Wu X, Chan J, Glesby A, Sham HP, Dutz JP, Levings MK, Jacobson K, Vallance BA
DOI: 10.1152/ajpgi.00320.2012
PubMed: 23019194
12/2012

Gastroesophageal Reflux Disease in Children and AdolescentsWhen and How to Treat
Pediatric Drugs
Matthew W. Carroll, Kevan Jacobson
DOI: 10.2165/11594360-000000000-00000
04/2012

Transient appearance of GPI-deficient population in a patient with azathioprine-associated bone marrow aplasia
Annals of Hematology
Arwa Z. Al Riyami, Kevan Jacobson, Jason Ford, Bakul I. Dalal
DOI: 10.1007/s00277-012-1449-7
04/2012

Seroconversion of hepatitis B envelope antigen (HBeAg) by entecavir in a child with chronic hepatitis B
Saudi Journal of Gastroenterology
MohammedY Hasosah, HebaS Ghandourah, AshrafF Alsahafi, GhassanA Sukkar, Kevan Jacobson
DOI: 10.4103/1319-3767.96465
2012

Helicobacter pyloriin First Nations and Recent Immigrant Populations in Canada
Canadian Journal of Gastroenterology
Nicola L Jones, Naoki Chiba, Carlo Fallone, Alan Thomson, Richard Hunt, Kevan Jacobson, Karen Goodman
DOI: 10.1155/2012/174529
2012

Perinatal cytomegalovirus hepatitis in Saudi infants: A case series
Saudi Journal of Gastroenterology
MohammedY Hasosah, AbdulfattahW Al-Amri, AshrafF Alsahafi, KhaledJ Alghamdi, SuzaneY Kutbi, GhassanA Sukkar, Kevan Jacobson
DOI: 10.4103/1319-3767.96461
2012

Induction and Maintenance Therapy With Infliximab for Children With Moderate to Severe Ulcerative Colitis
Clinical Gastroenterology and Hepatology
Jeffrey Hyams and Lakshmi Damaraju and Marion Blank and Jewel Johanns and Cynthia Guzzo and Harland S. Winter and Subra Kugathasan and Stanley Cohen and James Markowitz and Johanna C. Escher and Gigi Veereman–Wauters and Wallace Crandall and Robert Baldassano and Anne Griffiths
DOI: https://doi.org/10.1016/j.cgh.2011.11.026
2012

SHIP-Deficient Mice Develop Spontaneous Intestinal Inflammation and Arginase-Dependent Fibrosis
The American Journal of Pathology
Keith W. McLarren, Alexandra E. Cole, Shelley B. Weisser, Nicole S. Voglmaier, Victoria S. Conlin, Kevan Jacobson, Oana Popescu, Jean-Luc Boucher, Laura M. Sly
DOI: 10.1016/j.ajpath.2011.03.018
07/2011

Mucosa-Associated Lymphoid Tissue Lymphoma of the Lacrimal Gland: Sustained Remission after Eradication of Helicobacter Pylori Infection
Case Reports in Gastrointestinal Medicine
Mohammed Hasosah, Abdullah Baothman, Mohamed Satti, Suzanne Kutbi, Khaled Alghamdi, Kevan Jacobson
DOI: 10.1155/2011/945752
2011

Loss of Single Immunoglobulin Interlukin-1 Receptor-Related Molecule Leads to Enhanced Colonic Polyposis in Apcmin Mice
Gastroenterology
Hui Xiao, Weiguo Yin, Mohammed A. Khan, Muhammet F. Gulen, Hang Zhou, Ho Pan Sham, Kevan Jacobson, Bruce A. Vallance, Xiaoxia Li
DOI: 10.1053/j.gastro.2010.04.043
08/2010

Perinatal lipid nutrition alters early intestinal development and programs the response to experimental colitis in young adult rats
American Journal of Physiology-Gastrointestinal and Liver Physiology
Sheila M. Innis, Chuanbin Dai, Xiujuan Wu, Alison M. J. Buchan, Kevan Jacobson
DOI: 10.1152/ajpgi.00258.2010
2010

Vasoactive intestinal peptide ameliorates intestinal barrier disruption associated with Citrobacter rodentium-induced colitis.
American journal of physiology. Gastrointestinal and liver physiology
Conlin VS, Wu X, Nguyen C, Dai C, Vallance BA, Buchan AM, Boyer L, Jacobson K
DOI: 10.1152/ajpgi.90551.2008
PubMed: 19661153
10/2009

Esophageal candidiasis in an immunocompetent girl
World Journal of Pediatrics
Mohammed Yahya Hasosah, Mahmmod Showail, Ashraf Al-sahafi, Mohammed Satti, Kevan Jacobson
DOI: 10.1007/s12519-009-0031-4
05/2009

Persistent elevated tissue-transglutaminase in cystic fibrosis.
Journal of paediatrics and child health
Hasosah M, Davidson G, Jacobson K
DOI: 10.1111/j.1440-1754.2009.01477.x
PubMed: 19426374
04/2009

Canadian Association of Gastroenterology Clinical Practice Guidelines: The Use of Tumour Necrosis Factor-Alpha Antagonist Therapy in Crohn’s Disease
Canadian Journal of Gastroenterology
Daniel C Sadowski, Charles N Bernstein, Alain Bitton, Ken Croitoru, Richard N Fedorak, Anne Griffiths, the CAG Crohn’s Consensus Group
DOI: 10.1155/2009/201430
2009

Dietary Lipids in Early Development and Intestinal Inflammatory Disease
Nutrition Reviews
Sheila M. Innis, Kevan Jacobson
DOI: 10.1111/j.1753-4887.2007.tb00361.x
06/2008

Response to Dr. Rashid and Colleagues
The American Journal of Gastroenterology
Vered Pinsk, Kevan Jacobson
DOI: 10.1111/j.1572-0241.2007.01562_4.x
01/2008

Saccharomyces boulardii ameliorates Citrobacter rodentium-induced colitis through actions on bacterial virulence factors.
American journal of physiology. Gastrointestinal and liver physiology
Wu X, Vallance BA, Boyer L, Bergstrom KS, Walker J, Madsen K, O'Kusky JR, Buchan AM, Jacobson K
DOI: 10.1152/ajpgi.00173.2007
PubMed: 18032474
01/2008

Improvement in Biomarkers of Bone Formation During Infliximab Therapy in Pediatric Crohn's Disease: Results of the REACH Study
Clinical Gastroenterology and Hepatology
Meena Thayu, Mary B. Leonard, Jeffrey S. Hyams, Wallace V. Crandall, Subra Kugathasan, Anthony R. Otley, Allan Olson, Jewel Johanns, Colleen W. Marano, Robert B. Heuschkel, Gigi Veereman–Wauters, Anne M. Griffiths, Robert N. Baldassano
DOI: 10.1016/j.cgh.2008.07.010
2008

Low Prevalence ofHelicobacter PyloriInfection in Canadian Children: A Cross-Sectional Analysis
Canadian Journal of Gastroenterology
Idit Segal, Anthony Otley, Robert Issenman, David Armstrong, Victor Espinosa, Ruth Cawdron, Muhammad G Morshed, Kevan Jacobson
DOI: 10.1155/2008/410176
2008

The effect of dietary oils on cecal microflora in experimental colitis in mice.
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
Hekmatdoost A, Feizabadi MM, Djazayery A, Mirshafiey A, Eshraghian MR, Yeganeh SM, Sedaghat R, Jacobson K
PubMed: 19112187
2008

Helicobacter Pylori Infection in Canadian and Related Arctic Aboriginal Populations
Canadian Journal of Gastroenterology
Karen J Goodman and Kevan Jacobson and Sander Veldhuyzen van Zanten
DOI: 10.1155/2008/258610
2008

Surgical intervention in children with Crohn's disease.
International journal of colorectal disease
Leonor R, Jacobson K, Pinsk V, Webber E, Lemberg DA
DOI: 10.1007/s00384-007-0281-3
PubMed: 17530264
09/2007

Differential responses of VIPergic and nitrergic neurons in paediatric patients with Crohn's disease
Autonomic Neuroscience
Lee Boyer, Dolar Sidpra, Gareth Jevon, Alison M. Buchan, Kevan Jacobson
DOI: 10.1016/j.autneu.2007.03.001
07/2007

Inflammatory Bowel Disease in the South Asian Pediatric Population of British Columbia
The American Journal of Gastroenterology
Vared Pinsk, Daniel A. Lemberg, Karan Grewal, Collin C. Barker, Richard A. Schreiber, Kevan Jacobson
DOI: 10.1111/j.1572-0241.2007.01124.x
05/2007

Induction and Maintenance Infliximab Therapy for the Treatment of Moderate-to-Severe Crohn’s Disease in Children
Gastroenterology
Jeffrey Hyams, Wallace Crandall, Subra Kugathasan, Anne Griffiths, Allan Olson, Jewel Johanns, Grace Liu, Suzanne Travers, Robert Heuschkel, James Markowitz, Stanley Cohen, Harland Winter, Gigi Veereman–Wauters, George Ferry, Robert Baldassano
DOI: 10.1053/j.gastro.2006.12.003
03/2007

Pediatric Gastroenterology – are you Kidding?
Canadian Journal of Gastroenterology
Kevan Jacobson, Paul C Adams
DOI: 10.1155/2007/823540
2007

Canadian Pediatric Gastroenterology Workforce: Current Status, Concerns and Future Projections
Canadian Journal of Gastroenterology
Véronique Morinville, Éric Drouin, Dominique Lévesque, Victor M Espinosa, Kevan Jacobson
DOI: 10.1155/2007/292054
2007

Dietary lipids and intestinal inflammatory disease
The Journal of Pediatrics
Sheila M. Innis, Vered Pinsk, Kevan Jacobson
DOI: 10.1016/j.jpeds.2006.06.058
11/2006

Citrobacter rodentium infection causes both mitochondrial dysfunction and intestinal epithelial barrier disruption in vivo: role of mitochondrial associated protein (Map).
Cellular microbiology
Ma C, Wickham ME, Guttman JA, Deng W, Walker J, Madsen KL, Jacobson K, Vogl WA, Finlay BB, Vallance BA
DOI: 10.1111/j.1462-5822.2006.00741.x
PubMed: 16759225
10/2006

Upper Gastrointestinal Biopsies and Pediatric Crohn’s Disease
Journal of Pediatric Gastroenterology and Nutrition
Mohammed Hasosah and Anne Gomez and Gareth Jevon and Kevan Jacobson
DOI: 10.1097/00005176-200610000-00160
10/2006

The Congenital Intrahepatic Arterioportal Fistula SyndromeElucidation and Proposed Classification
Journal of Pediatric Gastroenterology and Nutrition
Seamus P. Norton, Kevan Jacobson, Stanley P. Moroz, Gordon Culham, Vicky Ng, Justine Turner, Philip John
DOI: 10.1097/01.mpg.0000221890.13630.ad
08/2006

Noradrenergic and cholinergic neural pathways mediate stress-induced reactivation of colitis in the rat
Autonomic Neuroscience
Paul R. Saunders, Paula Miceli, Bruce A. Vallance, Lu Wang, Sarah Pinto, Gervais Tougas, Markad Kamath, Kevan Jacobson
DOI: 10.1016/j.autneu.2005.12.002
01/2006

A Randomized Trial of Yoga for Adolescents with Irritable Bowel Syndrome
Pain Research and Management
Leora Kuttner, Christine T Chambers, Janine Hardial, David M Israel, Kevan Jacobson, Kathy Evans
DOI: 10.1155/2006/731628
2006

A Clinical Quiz: An Unusual Cause of Upper GI Bleeding in a Neonate
Journal of Pediatric Gastroenterology and Nutrition
T G Lokesh Babu and Kevan Jacobson
DOI: 10.1097/01.mpg.0000147132.59353.b9
11/2005

PEDIATRIC INFLAMMATORY BOWEL DISEASE: THE BRITISH COLUMBIA EXPERIENCE169
Journal of Pediatric Gastroenterology and Nutrition
Vered Pinsk, Daniel A Lemberg, Rosario Leonor, Collin Barker, Richard Schreiber, David M Israel, Kevan Jacobson
DOI: 10.1097/01.mpg.0000182025.84053.ed
10/2005

The changing pattern of Pediatric IBD at British Columbia’s Children’s Hospital168
Journal of Pediatric Gastroenterology and Nutrition
Vered Pinsk and Daniel A Lemberg and Collin Barker and Richard Schreiber and David M Israel and Kevan Jacobson
DOI: 10.1097/01.mpg.0000182024.84053.a4
10/2005

Endoscopic Hemostasis in a Neonate with a Bleeding Duodenal Ulcer
Journal of Pediatric Gastroenterology and Nutrition
T G Lokesh Babu, Kevan Jacobson, Min Phang, Mark R Riley, Collin C Barker
DOI: 10.1097/01.mpg.0000173602.39271.ff
08/2005

Positron Emission Tomography in the Investigation of Pediatric Inflammatory Bowel Disease
Inflammatory Bowel Diseases
Daniel A Lemberg, Robert M Issenman, Ruth Cawdron, Tim Green, John Mernagh, Stephen J Skehan, Claude Nahmias, Kevan Jacobson
DOI: 10.1097/01.mib.0000172810.49619.cb
08/2005

Intestinal responsiveness to experimental colitis in young rats is altered by maternal diet
American Journal of Physiology-Gastrointestinal and Liver Physiology
Kevan Jacobson, Harmeet Mundra, Sheila M. Innis
DOI: 10.1152/ajpgi.00459.2004
07/2005

Canadian Helicobacter Study Group Consensus Conference: Update on the approach to Helicobacter pylori infection in children and adolescents--an evidence-based evaluation.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie
Bourke B, Ceponis P, Chiba N, Czinn S, Ferraro R, Fischbach L, Gold B, Hyunh H, Jacobson K, Jones NL, Koletzko S, Lebel S, Moayyedi P, Ridell R, Canadian Helicobacter Study Group
PubMed: 16010300
07/2005

Myenteric plexus injury and apoptosis in experimental colitis
Autonomic Neuroscience
Lee Boyer, Mehran Ghoreishi, Valerie Templeman, Bruce A. Vallance, Alison M. Buchan, Gareth Jevon, Kevan Jacobson
DOI: 10.1016/j.autneu.2004.10.006
01/2005

The Changing Prevalence of Helicobacter Pylori Infection in Canadian Children: Should Screening Be Performed in High-Risk Children?
Canadian Journal of Gastroenterology
Kevan Jacobson
DOI: 10.1155/2005/840909
2005

Canadian Helicobacter Study Group Consensus Conference: Update on the Approach to Helicobacter Pylori Infection in Children and Adolescents – an Evidence-Based Evaluation
Canadian Journal of Gastroenterology
Nicola L Jones, Philip Sherman, Carlo A Fallone, Nigel Flook, Fiona Smaill, Sander Veldhuyzen van Zanten, Richard Hunt, Alan Thomson, Canadian Helicobacter Study Group
DOI: 10.1155/2005/390932
2005

Cytomegalovirus-Associated Hemophagocytic Syndrome in a Child With Crohn Disease Receiving Azathioprine
Journal of Pediatric Gastroenterology and Nutrition
T. G. Lokesh Babu, Dana Boctor, Alyson Davey, Mason C. Bond, Kevan Jacobson
DOI: 10.1097/00005176-200410000-00020
10/2004

Canadian Helicobacter Study Group Consensus Conference: Update on the Management ofHelicobacter pylori- An Evidence-Based Evaluation of Six Topics Relevant to Clinical Outcomes in Patients Evaluated forH pyloriInfection
Canadian Journal of Gastroenterology
Richard Hunt, Carlo Fallone, Sander Veldhuyzan van Zanten, Phil Sherman, Fiona Smaill, Nigel Flook, Alan Thomson, all participants of CHSG 2004
DOI: 10.1155/2004/326767
2004

Say Goodbye and Say Hello: The Transition from Pediatric to Adult Gastroenterology
Canadian Journal of Gastroenterology
Jorge L Pinzon, Kevan Jacobson, John Reiss
DOI: 10.1155/2004/474232
2004

Curcumin attenuates DNB-induced murine colitis.
American journal of physiology. Gastrointestinal and liver physiology
Salh B, Assi K, Templeman V, Parhar K, Owen D, Gómez-Muñoz A, Jacobson K
DOI: 10.1152/ajpgi.00449.2002
PubMed: 12637253
07/2003

Host susceptibility to the attaching and effacing bacterial pathogen Citrobacter rodentium.
Infection and immunity
Vallance BA, Deng W, Jacobson K, Finlay BB
DOI: 10.1128/iai.71.6.3443-3453.2003
PubMed: 12761129
06/2003

Comparison of Multidetector CT and Barium Studies of the Small Bowel: Inflammatory Bowel Disease in Children
American Journal of Roentgenology
Douglas H. Jamieson and Peter J. Shipman and David M. Israel and Kevan Jacobson
DOI: 10.2214/ajr.180.5.1801211
05/2003

Cholinergic pathways modulate experimental dinitrobenzene sulfonic acid colitis in rats
Autonomic Neuroscience
P.C Miceli, K Jacobson
DOI: 10.1016/s1566-0702(03)00023-7
04/2003

Esophageal Crohn Disease in Children: A Clinical Spectrum
Journal of Pediatric Gastroenterology and Nutrition
Kannan Ramaswamy, Kevan Jacobson, Gareth Jevon, David Israel
DOI: 10.1097/00005176-200304000-00006
04/2003

Neutrophil granulocytes mediate enteric nervous system injury in a murine model of colitis
Gastroenterology
Kevan Jacobson, Lee C. Boyer, Mehran Ghoreishi, Valerie Templeman, Bruce A. Vallance, Gareth Jevon
DOI: 10.1016/s0016-5085(03)81636-0
04/2003

Modulation of inducible nitric oxide synthase expression by the attaching and effacing bacterial pathogen citrobacter rodentium in infected mice.
Infection and immunity
Vallance BA, Deng W, De Grado M, Chan C, Jacobson K, Finlay BB
DOI: 10.1128/iai.70.11.6424-6435.2002
PubMed: 12379723
11/2002

Etiology of dyspepsia: implications for empirical therapy
Canadian Journal of Gastroenterology
09/2002

EVIDENCE-BASED FEEDING GUIDELINES FOR VERY LOW-BIRTH-WEIGHT INFANTS
Advances in Neonatal Care
SHAHIROSE S. PREMJI, BOSCO PAES, KEVAN JACOBSON, LORRAINE CHESSELL
DOI: 10.1053/adnc.2002.31511
02/2002

A MATCHED COHORT STUDY OF FEEDING PRACTICE GUIDELINES FOR INFANTS WEIGHING LESS THAN 1,500 G
Advances in Neonatal Care
SHAHIROSE S. PREMJI, LORRAINE CHESSELL, BOSCO PAES, JANET PINELLI, KEVAN JACOBSON
DOI: 10.1053/adnc.2002.31510
02/2002

Epstein-Barr Virus Infection in Transplant Recipients: Sumary of a Workshop on Surveillance, Prevention and Treatment
Canadian Journal of Infectious Diseases
Upton Allen, Caroline Alfieri, Jutta Preiksaitis, Atul Humar, Dorothy Moore, Bruce Tapiero, Raymond Tellier, Michael Green, Dele Davies, Diane Hébert, Sheila Weitzman, Martin Petric, Kevan Jacobson, Canadian PTLD Workshop Group #x2013; 1999
DOI: 10.1155/2002/634318
2002

The changing face of celiac disease
Paediatrics & Child Health
Rameeta Lad, Kevan Jacobson
DOI: 10.1093/pch/6.9.644
11/2001

INFECTIOUS DIARRHEA IN CHILDREN
Gastroenterology Clinics of North America
Kannan Ramaswamy, Kevan Jacobson
DOI: 10.1016/s0889-8553(05)70201-6
09/2001

Development of interstitial cells of Cajal in a full-term infant without an enteric nervous system
Gastroenterology
Jan D. Huizinga, Irene Berezin, Kanishka Sircar, Bryan Hewlett, Graeme Donnelly, Premysl Bercik, Catherine Ross, Talal Algofi, Peter Fitzgerald, Tara Der, Robert H. Riddell, Stephen M. Collins, Kevan Jacobson
DOI: 10.1053/gast.2001.21200
02/2001

Gastric Acid Secretory Response inHelicobacter pylori-Positive Patients with Duodenal Ulcer Disease
Canadian Journal of Gastroenterology
Kevan Jacobson, Naoki Chiba, Ying Chen, Miguel Barrientos, Cindy James, Robert H Riddell, Richard H Hunt
DOI: 10.1155/2001/764615
2001

Autonomic nervous system (ANS) dysfunction exacerbates inflammation in dextran sulfate (DSS) model of ulcerative colitis
Gastroenterology
Paula C. Miceli, Paul Saunders, Veljko Djuric, Kevan Jacobson
DOI: 10.1016/s0016-5085(00)85665-6
04/2000

Stress reactivation colitis and the role of the autonomic nervous system (ANS)
Gastroenterology
Paul Saunders, Markad Kamath, Kevan Jacobson
DOI: 10.1016/s0016-5085(00)85664-4
04/2000

An Unusual Cause of Recurrent Pancreatitis: Duodenal Duplication Cyst
Canadian Journal of Gastroenterology
Rameeta J Lad, Peter Fitzgerald, Kevan Jacobson
DOI: 10.1155/2000/152809
2000

Omeprazole for treatment of chronic erosive esophagitis in children: A multicenter study of efficacy, safety, tolerability and dose requirements
The Journal of Pediatrics
Eric Hassall, David Israel, Ross Shepherd, Michael Radke, Agneta Dalväg, Birgitta Sköld, Ola Junghard, Per Lundborg
DOI: 10.1067/mpd.2000.109607
2000

18F-fluorodeoxyglucose positron tomography in diagnosis of paediatric inflammatory bowel disease
The Lancet
Robert Issenman, John Mernagh, Claude Nahmias, Kevan Jacobson, Stephen J Skehan
DOI: 10.1016/s0140-6736(99)80021-x
09/1999

CanadianHelicobacterStudy Group Consensus Conference on the Approach toHelicobacter PyloriInfection in Children and Adolescents
Canadian Journal of Gastroenterology
P Sherman, E Hassall, RH Hunt, CA Fallone, S Veldhuyzen van Zanten, ABR Thomson, Canadian Helicobacter Study Group
DOI: 10.1155/1999/934285
1999

Neuro-modulation of stress-induced reactivation of experimental colitis
Gastroenterology
P.C. Miceli and V. Djuric and K. Jacobson
DOI: 10.1016/s0016-5085(98)84734-3
04/1998

Neuroimmune mechanisms in a rat model of stress-induced reactivation of experimental colitis
Gastroenterology
P.C. Miceli, B.A. Vallance, K. Jacobson
DOI: 10.1016/s0016-5085(98)84227-3
04/1998

Patients’ Diets and Preferences in a Pediatric Population with Inflammatory Bowel Disease
Canadian Journal of Gastroenterology
Timothy J Green, Robert M Issenman, Kevan Jacobson
DOI: 10.1155/1998/928706
1998

The mechanism of altered neural function in a rat model of acute colitis.
Gastroenterology
Jacobson K, McHugh K, Collins SM
DOI: 10.1016/s0016-5085(97)70230-0
PubMed: 8978354
01/1997

Previous inflammation alters the response of the rat colon to stress
Gastroenterology
SM Collins, K McHugh, K Jacobson, I Khan, R Riddell, K Murase, HP Weingarten
DOI: 10.1016/s0016-5085(96)70012-4
1996

Experimental colitis alters myenteric nerve function at inflamed and noninflamed sites in the rat
Gastroenterology
Kevan Jacobson, Kevin McHugh, Stephen M. Collins
DOI: 10.1016/0016-5085(95)90378-x
09/1995

The selective beneficial effects of nitric oxide inhibition in experimental colitis.
The American journal of physiology
Hogaboam CM, Jacobson K, Collins SM, Blennerhassett MG
PubMed: 7537457
04/1995

Interpreting abnormalities in routine liver biochemistry
Canadian Family Physician
1992

Research

Current projects
Epidemiology of paediatric IBD

Current Projects
Examining the role of maternal dietary lipid in modulating epithelial barrier function and intestinal immune response of the young offspring to chemically induced colitis

Current Projects
Determining the effect of intestinal inflammation on neuro-epithelial function in animal models of IBD

Honours & Awards

Canadian Children Inflammatory Bowel Disease Network, CIHR and CH.I.L.D Foundation – 2013

Research Group Members

Franziska Graef
Hongbing Yu, Research Associate
Justin Chan
Sandy Wu, Research Manager
George Evans
Alice Foster
Genelle Healey, Postdoctoral Fellow