Overview

There is increasing evidence to suggest that intestinal inflammation affects the organization and function of the intestinal nervous system, which controls how our intestine works. As a result, changes in nerve function may alter how the inestine works, worsen inflammation and aggravate the symptoms in IBD. In our studies we are examining the nerve-intestinal lining responses to inflammation in animal models if IBD and in our children with IBD. We will determine what nerve changes occur in assoications with intestinal inflammation, how these changes affectr the function of the intestinal lining cells and whether these changes persist. We will also examine the potential benfit of probiotics (living non-harmful bacteria).

We are also examining the effects of maternal dietary fat on intestinal lining cells (which protect the host from harmful dietary agents and infectious organisms) and on the intestinal immune response in young offspring.

Publications

Frontline defenders: Goblet cell mediators dictate host-microbe interactions in the intestinal tract during health and disease.
American journal of physiology. Gastrointestinal and liver physiology
Allaire JM and Morampudi V and Crowley SM and Stahl M and Yu H and Bhullar K and Knodler LA and Bressler B and Jacobson K and Vallance BA
DOI: 10.1152/ajpgi.00181.2017
PubMed: 29122749
11/2017

Concomitant Therapy with Immunomodulator Enhances Infliximab Durability in Pediatric Inflammatory Bowel Disease
Inflammatory Bowel Diseases
Julianna Cheng and Zachary Hamilton and Matthew Smyth and Collin Barker and David Israel and Kevan Jacobson
DOI: 10.1097/mib.0000000000001212
10/2017

Repression of Salmonella host cell invasion by aromatic small molecules from the human fecal metabolome.
Applied and environmental microbiology
Peixoto RJM and Alves ES and Wang M and Ferreira RBR and Granato A and Han J and Gill H and Jacobson K and Lobo LA and Domingues RMCP and Borchers CH and Davies JE and Finlay BB and Antunes LCM
DOI: 10.1128/aem.01148-17
PubMed: 28754707
07/2017

Rural and Urban Residence During Early Life is Associated with Risk of Inflammatory Bowel Disease: A Population-Based Inception and Birth Cohort Study
The American Journal of Gastroenterology
DOI: 10.1038/ajg.2017.208
PubMed: 28741616
07/2017

Trends in Epidemiology of Pediatric Inflammatory Bowel Disease in Canada: Distributed Network Analysis of Multiple Population-Based Provincial Health Administrative Databases.
The American journal of gastroenterology
Benchimol EI and Bernstein CN and Bitton A and Carroll MW and Singh H and Otley AR and Vutcovici M and El-Matary W and Nguyen GC and Griffiths AM and Mack DR and Jacobson K and Kaplan GG
DOI: 10.1038/ajg.2017.97
PubMed: 28417994
07/2017

Long-term Outcomes of Infliximab use for Pediatric Crohn's disease
Journal of Pediatric Gastroenterology and Nutrition
Jennifer C. deBruyn and Kevan Jacobson and Wael El-Matary and Matthew Carroll and Eytan Wine and Iwona Wrobel and Mariel Van Woudenberg and Hien Q. Huynh
DOI: 10.1097/mpg.0000000000001672
06/2017

Ulcerative Colitis-Associated Escherichia Coli Colonize the Intestinal Mucosa of Susceptible Host and Promote Colitis via Hemolysin Production
Gastroenterology
Hengameh Chloé Mirsepasi-Lauridsen and Hyungjun Yang and Else Bosman and Carsten Struve and Hongbing Yu and Xiujuan Wu and Caixia Ma and Abbas Fotovati and Andreas M. Petersen and Kevan Jacobson and Karen A. Krogfelt and Bruce Vallance
DOI: 10.1016/s0016-5085(17)32838-x
04/2017

Capsule Endoscopy Complements Magnetic Resonance Enterography and Ileo-Colonoscopy in the Evaluation of Suspected Small Bowel Crohn’s Disease in Pediatric Patients
Gastroenterology
David O. Prichard and Zachary Hamilton and Thomas Savage and Matthew Smyth and Carlie Penner and Alam Lakhani and Matthew Carroll and Ahmed A. Alsarkhy and Daniel Lemberg and Robert A. Enns and Robert J. Prosser and Daniel Jamieson and Kevan Jacobson
DOI: 10.1016/s0016-5085(17)32196-0
04/2017

The Prevalence and Predictors of Anti-TNF Failure in a Population based Sample of Persons with IBD
Gastroenterology
Laura E. Targownik and Charles N. Bernstein and Harminder Singh and Aruni Tennakoon and Stella leung and Zoann Nugent and Lisa Lix and Kevan Jacobson and Juan-Nicolas Pena-Sanchez and Gilaad Kaplan
DOI: 10.1016/s0016-5085(17)31463-4
04/2017

Milk Fat Globule Membrane Supplementation in Formula Modulates the Neonatal Gut Microbiome and Normalizes Intestinal Development.
Scientific reports
Bhinder G and Allaire JM and Garcia C and Lau JT and Chan JM and Ryz NR and Bosman ES and Graef FA and Crowley SM and Celiberto LS and Berkmann JC and Dyer RA and Jacobson K and Vallance BA
DOI: 10.1038/srep45274
PubMed: 28349941
03/2017

Tricellular Tight Junction Protein Tricellulin Is Targeted by the Enteropathogenic Escherichia coli Effector EspG1, Leading to Epithelial Barrier Disruption.
Infection and immunity
Morampudi V and Graef FA and Stahl M and Dalwadi U and Conlin VS and Huang T and Vallance BA and Yu HB and Jacobson K
DOI: 10.1128/iai.00700-16
PubMed: 27795363
01/2017

Transition clinic attendance is associated with improved beliefs and attitudes toward medicine in patients with inflammatory bowel disease
World Journal of Gastroenterology
Nancy Fu and Kevan Jacobson and Andrew Round and Kathi Evans and Hong Qian and Brian Bressler
DOI: 10.3748/wjg.v23.i29.5405
2017

Pneumocystis jirovecii Pneumonia in Pediatric Inflammatory Bowel Disease: A Case Report and Literature Review.
Frontiers in pediatrics
Lawrence SJ and Sadarangani M and Jacobson K
DOI: 10.3389/fped.2017.00161
PubMed: 28791279
2017

Allied Health Professional Support in Pediatric Inflammatory Bowel Disease: A Survey from the Canadian Children Inflammatory Bowel Disease Network—A Joint Partnership of CIHR and the CH.I.L.D. Foundation
Canadian Journal of Gastroenterology and Hepatology
Wael El-Matary and Eric I. Benchimol and David Mack and Hien Q. Huynh and Jeff Critch and Anthony Otley and Colette Deslandres and Kevan Jacobson and Jennifer deBruyn and Matthew W. Carroll and Eytan Wine and Johan Van Limbergen and Mary Sherlock and Kevin Bax and Sally Lawrence and Ernest Seidman and Robert Issenman and Thomas D. Walters and Peter Church and Anne M. Griffiths
DOI: 10.1155/2017/3676474
2017

Association of host genome with intestinal microbial composition in a large healthy cohort
Nature Genetics
Williams Turpin and GEM Project Research Consortium and Osvaldo Espin-Garcia and Wei Xu and Mark S Silverberg and David Kevans and Michelle I Smith and David S Guttman and Anne Griffiths and Remo Panaccione and Anthony Otley and Lizhen Xu and Konstantin Shestopaloff and Gabriel Moreno-Hagelsieb and Andrew D Paterson and Kenneth Croitoru
DOI: 10.1038/ng.3693
10/2016

The goblet cell-derived mediator RELM-ß drives spontaneous colitis in Muc2-deficient mice by promoting commensal microbial dysbiosis.
Mucosal Immunology
Morampudi V and Dalwadi U and Bhinder G and Sham HP and Gill SK and Chan J and Bergstrom KS and Huang T and Ma C and Jacobson K and Gibson DL and Vallance BA
DOI: 10.1038/mi.2015.140
PubMed: 26813339
09/2016

Pediatric Inflammatory Bowel Disease Among South Asians Living in British Columbia, Canada
Inflammatory Bowel Diseases
Matthew W. Carroll and Zachary Hamilton and Hira Gill and Jonathan Simkin and Matthew Smyth and Victor Espinosa and Brian Bressler and Kevan Jacobson
DOI: 10.1097/mib.0000000000000651
02/2016

Activity of SHIP, Which Prevents Expression of Interleukin 1ß, Is Reduced in Patients With Crohn's Disease.
Gastroenterology
Ngoh EN and Weisser SB and Lo Y and Kozicky LK and Jen R and Brugger HK and Menzies SC and McLarren KW and Nackiewicz D and van Rooijen N and Jacobson K and Ehses JA and Turvey SE and Sly LM
DOI: 10.1053/j.gastro.2015.09.049
PubMed: 26481854
02/2016

Dietary vitamin D3 deficiency alters intestinal mucosal defense and increases susceptibility to Citrobacter rodentium-induced colitis.
American journal of physiology. Gastrointestinal and liver physiology
Ryz NR and Lochner A and Bhullar K and Ma C and Huang T and Bhinder G and Bosman E and Wu X and Innis SM and Jacobson K and Vallance BA
DOI: 10.1152/ajpgi.00006.2015
PubMed: 26336925
11/2015

The Crohn's disease-associated polymorphism in ATG16L1 (rs2241880) reduces SHIP gene expression and activity in human subjects.
Genes and immunity
Ngoh EN and Brugger HK and Monajemi M and Menzies SC and Hirschfeld AF and Del Bel KL and Jacobson K and Lavoie PM and Turvey SE and Sly LM
DOI: 10.1038/gene.2015.30
PubMed: 26226011
10/2015

Mo1791 Ulcerative Colitis-Associated Escherichia coli Colonize the Ileum and Cecum of Infected Mice by Adhering to the Intestinal Epithelium
Gastroenterology
Hengameh Chloé Lauridsen and Hyungjun Yang and Else Bosman and Hongbing Yu and Xiujuan Wu and Caixia Ma and Carsten Struve and Andreas M. Petersen and Karen A. Krogfelt and Kevan Jacobson and Bruce Vallance
DOI: 10.1016/s0016-5085(15)32421-5
04/2015

Vasoactive intestinal peptide prevents PKCe-induced intestinal epithelial barrier disruption during EPEC infection.
American journal of physiology. Gastrointestinal and liver physiology
Morampudi V and Conlin VS and Dalwadi U and Wu X and Marshall KC and Nguyen C and Vallance BA and Jacobson K
DOI: 10.1152/ajpgi.00195.2014
PubMed: 25501546
03/2015

Maternal exposure to fish oil primes offspring to harbor intestinal pathobionts associated with altered immune cell balance
Gut Microbes
DL Gibson and SK Gill and K Brown and N Tasnim and S Ghosh and S Innis and K Jacobson
DOI: 10.1080/19490976.2014.997610
01/2015

Treatment Profile of Pediatric Inflammatory Bowel Disease in Saudi Arabia: Issues in Treatment Adherence
Advances in Pharmacology and Pharmacy
Mohammed Hasosah and Mohammed El Mouzan and Omar Saadah and Khalid Al-Saleem and Abdulrahman Al-Hussaini and Ali Al Mehaidib and Badr Al Saleem and Khalid Alquair and Kevan Jacobson
DOI: 10.13189/app.2015.030402
2015

Vasoactive intestinal polypeptide promotes intestinal barrier homeostasis and protection against colitis in mice.
PloS one
Wu X and Conlin VS and Morampudi V and Ryz NR and Nasser Y and Bhinder G and Bergstrom KS and Yu HB and Waterhouse CC and Buchan AM and Popescu OE and Gibson WT and Waschek JA and Jacobson K
DOI: 10.1371/journal.pone.0125225
PubMed: 25932952
2015

P-057A: Detecting inflammation in pediatric inflammatory bowel disease: the role of fecal calprotectin and its impact on management
Journal of Crohn's and Colitis
A.J. Foster and K. Jacobson
DOI: 10.1016/s1873-9946(14)50074-8
09/2014

C reactive protein as a predictor of response to infliximab in pediatric Crohn’s disease
Journal of Crohn's and Colitis
A. Al-Sahafi and K. Jacobson and M. Smyth
DOI: 10.1016/s1873-9946(14)50084-0
09/2014

Antivirulence activity of the human gut metabolome.
mBio
Antunes LC and McDonald JA and Schroeter K and Carlucci C and Ferreira RB and Wang M and Yurist-Doutsch S and Hira G and Jacobson K and Davies J and Allen-Vercoe E and Finlay BB
DOI: 10.1128/mbio.01183-14
PubMed: 25073640
07/2014

Intestinal Epithelium-Specific MyD88 Signaling Impacts Host Susceptibility to Infectious Colitis by Promoting Protective Goblet Cell and Antimicrobial Responses
Infection and Immunity
Ganive Bhinder and Martin Stahl and Ho Pan Sham and Shauna M. Crowley and Vijay Morampudi and Udit Dalwadi and Caixia Ma and Kevan Jacobson and Bruce A. Vallance
DOI: 10.1128/iai.02045-14
06/2014

Tu1195 The Influence of Adolescent Transition Clinics on the Attitudes and Beliefs in Medicine in Patients With Inflammatory Bowel Disease
Gastroenterology
Nancy Fu and Kevan Jacobson and Andrew M. Round and Kathi Evans and Hong Qian and Brian Bressler
DOI: 10.1016/s0016-5085(14)62816-x
05/2014

25-Hydroxyvitamin D concentrations in children with Crohn's disease supplemented with either 2000 or 400 IU daily for 6 months: a randomized controlled study.
The Journal of pediatrics
Wingate KE and Jacobson K and Issenman R and Carroll M and Barker C and Israel D and Brill H and Weiler H and Barr SI and Li W and Lyon MR and Green TJ
DOI: 10.1016/j.jpeds.2013.11.071
PubMed: 24423431
04/2014

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
Journal of Visualized Experiments
Vijay Morampudi and Ganive Bhinder and Xiujuan Wu and Chuanbin Dai and Ho Pan Sham and Bruce A. Vallance and Kevan Jacobson
DOI: 10.3791/51297
02/2014

Role of Omega-6 and Omega-3 Fatty Acids in Inflammatory Bowel Disease
Pharma-Nutrition
Kevan Jacobson and Philip C. Calder
DOI: 10.1007/978-3-319-06151-1_5
2014

Attainment of Steroid-Free Clinical Remission and Normal Growth Among Canadian Children with Inflammatory Bowel Disease
Inflammatory Bowel Diseases
Walters Thomas and Benchimol Eric and Jacobson Kevan and El-Matary Wael and Deslandres Colette and Huynh Hien and Church Peter and Carroll Matthew and Wine Eytan and Mack David and Griffiths Anne
DOI: 10.1097/01.mib.0000456870.74875.ed
2014

Prevalence and Risk Factors of Helicobacter pylori Infection in Saudi Children: A Three-Year Prospective Controlled Study
Helicobacter
Mohammed Hasosah and Mohammed Satti and Amir Shehzad and Ashraf Alsahafi and Ghassan Sukkar and Abdullah Alzaben and Areej Sunaid and Abdullah Ahmed and Sami AlThubiti and Areej Mufti and Kevan Jacobson
DOI: 10.1111/hel.12172
2014

Pediatric inflammatory bowel disease in the western region of Saudi Arabia. A retrospective analysis.
Saudi Medical Journal
Hasosah MY and Sukkar GA and Alsahafi AF and Kutbi SY and Alzabn AA and Jacobson K
PubMed: 23756933
06/2013

925e Altered intestinal epithelial homeostasis in mice with a target mutation in the gene encoding vasoactive intestinal peptide (VIP)
Gastroenterology
Xiujuan Wu and Kevan Jacobson
DOI: 10.1016/s0016-5085(13)60583-1
05/2013

Dietary oils modify the host immune response and colonic tissue damage following Citrobacter rodentium infection in mice
American Journal of Physiology-Gastrointestinal and Liver Physiology
Azita Hekmatdoost and Xiujuan Wu and Vijay Morampudi and Sheila M. Innis and Kevan Jacobson
DOI: 10.1152/ajpgi.00292.2012
05/2013

The Relationship Between Common IBD-Associated Risk Alleles and Intestinal Permeability in a Cohort of Healthy First Degree Relatives of Individuals With Crohn's Disease
Gastroenterology
David Kevans and Karen Madsen and Mark S. Silverberg and Wei Xu and Konstantin Shestopaloff and Ummiye Venus Onay and Andrew D. Paterson and Anne M. Griffiths and Paul Moayyedi and Mark J. Ropeleski and Paul L. Beck and Charles N. Bernstein and Alain Bitton and Levinus A. Dieleman and David S. Guttman and Hien Q. Huynh and Kevan Jacobson and Gilaad G. Kaplan and John K. Marshall and Remo Panaccione and Ernest G. Seidman and Kathy Siminovitch and Denis Snider and Andrew Stadnyk and A. Hillary Steinhart and Michael Surette and Dan Turner and Bruce Vallance and Thomas D. Walters and Ken Croitoru
DOI: 10.1016/s0016-5085(13)63107-8
05/2013

Inflammatory Bowel Disease in the Pediatric South Asian Population of British Columbia, Canada: A Distinct and Severe Phenotype
Gastroenterology
Matthew W. Carroll and Hira S. Gill and Jonathan Simkin and Lee-Ann M. Carroll and Vered Pinsk and Victor M. Espinosa and Brian Bressler and Kevan Jacobson
DOI: 10.1016/s0016-5085(13)62389-6
05/2013

The Citrobacter rodentium Mouse Model: Studying Pathogen and Host Contributions to Infectious Colitis
Journal of Visualized Experiments
Ganive Bhinder and Ho Pan Sham and Justin M. Chan and Vijay Morampudi and Kevan Jacobson and Bruce A. Vallance
DOI: 10.3791/50222
02/2013

Magnetic Resonance Imaging of the Perineum in Pediatric Patients with Inflammatory Bowel Disease
Canadian Journal of Gastroenterology
Douglas H Jamieson and Peter Shipman and Kevan Jacobson
DOI: 10.1155/2013/624141
2013

Clinical nutrition knowledge of gastroenterology fellows: is there anything omitted?
Acta medica Iranica
Eslamian G and Jacobson K and Hekmatdoost A
PubMed: 24338195
2013

Changing Incidence of Inflammatory Bowel Disease: Environmental Influences and Lessons Learnt from the South Asian Population
Frontiers in Pediatrics
Alice Foster and Kevan Jacobson
DOI: 10.3389/fped.2013.00034
2013

Active vitamin D (1,25-dihydroxyvitamin D3) increases host susceptibility to Citrobacter rodentium by suppressing mucosal Th17 responses.
American journal of physiology. Gastrointestinal and liver physiology
Ryz NR and Patterson SJ and Zhang Y and Ma C and Huang T and Bhinder G and Wu X and Chan J and Glesby A and Sham HP and Dutz JP and Levings MK and Jacobson K and Vallance BA
DOI: 10.1152/ajpgi.00320.2012
PubMed: 23019194
12/2012

Gastroesophageal Reflux Disease in Children and Adolescents
Pediatric Drugs
Matthew W. Carroll and Kevan Jacobson
DOI: 10.2165/11594360-000000000-00000
04/2012

Transient appearance of GPI-deficient population in a patient with azathioprine-associated bone marrow aplasia
Annals of Hematology
Arwa Z. Al Riyami and Kevan Jacobson and Jason Ford and Bakul I. Dalal
DOI: 10.1007/s00277-012-1449-7
04/2012

Perinatal cytomegalovirus hepatitis in Saudi infants: A case series
Saudi Journal of Gastroenterology
MohammedY Hasosah and AbdulfattahW Al-Amri and AshrafF Alsahafi and KhaledJ Alghamdi and SuzaneY Kutbi and GhassanA Sukkar and Kevan Jacobson
DOI: 10.4103/1319-3767.96461
2012

Induction and Maintenance Therapy With Infliximab for Children With Moderate to Severe Ulcerative Colitis
Clinical Gastroenterology and Hepatology
Jeffrey Hyams and Lakshmi Damaraju and Marion Blank and Jewel Johanns and Cynthia Guzzo and Harland S. Winter and Subra Kugathasan and Stanley Cohen and James Markowitz and Johanna C. Escher and Gigi Veereman–Wauters and Wallace Crandall and Robert Baldassano and Anne Griffiths
DOI: https://doi.org/10.1016/j.cgh.2011.11.026
2012

Helicobacter pylori in First Nations and Recent Immigrant Populations in Canada
Canadian Journal of Gastroenterology
Nicola L Jones and Naoki Chiba and Carlo Fallone and Alan Thomson and Richard Hunt and Kevan Jacobson and Karen Goodman
DOI: 10.1155/2012/174529
2012

Seroconversion of hepatitis B envelope antigen (HBeAg) by entecavir in a child with chronic hepatitis B
Saudi Journal of Gastroenterology
MohammedY Hasosah and HebaS Ghandourah and AshrafF Alsahafi and GhassanA Sukkar and Kevan Jacobson
DOI: 10.4103/1319-3767.96465
2012

SHIP-Deficient Mice Develop Spontaneous Intestinal Inflammation and Arginase-Dependent Fibrosis
The American Journal of Pathology
Keith W. McLarren and Alexandra E. Cole and Shelley B. Weisser and Nicole S. Voglmaier and Victoria S. Conlin and Kevan Jacobson and Oana Popescu and Jean-Luc Boucher and Laura M. Sly
DOI: 10.1016/j.ajpath.2011.03.018
07/2011

Mucosa-Associated Lymphoid Tissue Lymphoma of the Lacrimal Gland: Sustained Remission after Eradication of Helicobacter Pylori Infection
Case Reports in Gastrointestinal Medicine
Mohammed Hasosah and Abdullah Baothman and Mohamed Satti and Suzanne Kutbi and Khaled Alghamdi and Kevan Jacobson
DOI: 10.1155/2011/945752
2011

Loss of Single Immunoglobulin Interlukin-1 Receptor-Related Molecule Leads to Enhanced Colonic Polyposis in Apcmin Mice
Gastroenterology
Hui Xiao and Weiguo Yin and Mohammed A. Khan and Muhammet F. Gulen and Hang Zhou and Ho Pan Sham and Kevan Jacobson and Bruce A. Vallance and Xiaoxia Li
DOI: 10.1053/j.gastro.2010.04.043
08/2010

Perinatal lipid nutrition alters early intestinal development and programs the response to experimental colitis in young adult rats
American Journal of Physiology-Gastrointestinal and Liver Physiology
Sheila M. Innis and Chuanbin Dai and Xiujuan Wu and Alison M. J. Buchan and Kevan Jacobson
DOI: 10.1152/ajpgi.00258.2010
2010

Vasoactive intestinal peptide ameliorates intestinal barrier disruption associated with Citrobacter rodentium-induced colitis.
American journal of physiology. Gastrointestinal and liver physiology
Conlin VS and Wu X and Nguyen C and Dai C and Vallance BA and Buchan AM and Boyer L and Jacobson K
DOI: 10.1152/ajpgi.90551.2008
PubMed: 19661153
10/2009

Esophageal candidiasis in an immunocompetent girl
World Journal of Pediatrics
Mohammed Yahya Hasosah and Mahmmod Showail and Ashraf Al-sahafi and Mohammed Satti and Kevan Jacobson
DOI: 10.1007/s12519-009-0031-4
05/2009

Persistent elevated tissue-transglutaminase in cystic fibrosis.
Journal of paediatrics and child health
Hasosah M and Davidson G and Jacobson K
DOI: 10.1111/j.1440-1754.2009.01477.x
PubMed: 19426374
04/2009

Canadian Association of Gastroenterology Clinical Practice Guidelines: The Use of Tumour Necrosis Factor-Alpha Antagonist Therapy in Crohn’s Disease
Canadian Journal of Gastroenterology
Daniel C Sadowski and Charles N Bernstein and Alain Bitton and Ken Croitoru and Richard N Fedorak and Anne Griffiths and the CAG Crohn’s Consensus Group
DOI: 10.1155/2009/201430
2009

Dietary Lipids in Early Development and Intestinal Inflammatory Disease
Nutrition Reviews
Sheila M. Innis and Kevan Jacobson
DOI: 10.1111/j.1753-4887.2007.tb00361.x
06/2008

Response to Dr. Rashid and Colleagues
The American Journal of Gastroenterology
Vered Pinsk and Kevan Jacobson
DOI: 10.1111/j.1572-0241.2007.01562_4.x
01/2008

Saccharomyces boulardii ameliorates Citrobacter rodentium-induced colitis through actions on bacterial virulence factors.
American journal of physiology. Gastrointestinal and liver physiology
Wu X and Vallance BA and Boyer L and Bergstrom KS and Walker J and Madsen K and O'Kusky JR and Buchan AM and Jacobson K
DOI: 10.1152/ajpgi.00173.2007
PubMed: 18032474
01/2008

Helicobacter PyloriInfection in Canadian and Related Arctic Aboriginal Populations
Canadian Journal of Gastroenterology
Karen J Goodman and Kevan Jacobson and Sander Veldhuyzen van Zanten
DOI: 10.1155/2008/258610
2008

Improvement in Biomarkers of Bone Formation During Infliximab Therapy in Pediatric Crohn's Disease: Results of the REACH Study
Clinical Gastroenterology and Hepatology
Meena Thayu and Mary B. Leonard and Jeffrey S. Hyams and Wallace V. Crandall and Subra Kugathasan and Anthony R. Otley and Allan Olson and Jewel Johanns and Colleen W. Marano and Robert B. Heuschkel and Gigi Veereman–Wauters and Anne M. Griffiths and Robert N. Baldassano
DOI: 10.1016/j.cgh.2008.07.010
2008

The effect of dietary oils on cecal microflora in experimental colitis in mice.
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
Hekmatdoost A and Feizabadi MM and Djazayery A and Mirshafiey A and Eshraghian MR and Yeganeh SM and Sedaghat R and Jacobson K
PubMed: 19112187
2008

Low Prevalence of Helicobacter Pylori Infection in Canadian Children: A Cross-Sectional Analysis
Canadian Journal of Gastroenterology
Idit Segal and Anthony Otley and Robert Issenman and David Armstrong and Victor Espinosa and Ruth Cawdron and Muhammad G Morshed and Kevan Jacobson
DOI: 10.1155/2008/410176
2008

Surgical intervention in children with Crohn's disease.
International journal of colorectal disease
Leonor R and Jacobson K and Pinsk V and Webber E and Lemberg DA
DOI: 10.1007/s00384-007-0281-3
PubMed: 17530264
09/2007

Differential responses of VIPergic and nitrergic neurons in paediatric patients with Crohn's disease
Autonomic Neuroscience
Lee Boyer and Dolar Sidpra and Gareth Jevon and Alison M. Buchan and Kevan Jacobson
DOI: 10.1016/j.autneu.2007.03.001
07/2007

Inflammatory Bowel Disease in the South Asian Pediatric Population of British Columbia
The American Journal of Gastroenterology
Vared Pinsk and Daniel A. Lemberg and Karan Grewal and Collin C. Barker and Richard A. Schreiber and Kevan Jacobson
DOI: 10.1111/j.1572-0241.2007.01124.x
05/2007

Induction and Maintenance Infliximab Therapy for the Treatment of Moderate-to-Severe Crohn’s Disease in Children
Gastroenterology
Jeffrey Hyams and Wallace Crandall and Subra Kugathasan and Anne Griffiths and Allan Olson and Jewel Johanns and Grace Liu and Suzanne Travers and Robert Heuschkel and James Markowitz and Stanley Cohen and Harland Winter and Gigi Veereman–Wauters and George Ferry and Robert Baldassano
DOI: 10.1053/j.gastro.2006.12.003
03/2007

Pediatric Gastroenterology – are you Kidding?
Canadian Journal of Gastroenterology
Kevan Jacobson and Paul C Adams
DOI: 10.1155/2007/823540
2007

Canadian Pediatric Gastroenterology Workforce: Current Status, Concerns and Future Projections
Canadian Journal of Gastroenterology
Véronique Morinville and Éric Drouin and Dominique Lévesque and Victor M Espinosa and Kevan Jacobson
DOI: 10.1155/2007/292054
2007

Dietary lipids and intestinal inflammatory disease
The Journal of Pediatrics
Sheila M. Innis and Vered Pinsk and Kevan Jacobson
DOI: 10.1016/j.jpeds.2006.06.058
11/2006

UPPER GASTROINTESTINAL BIOPSIES AND PEDIATRIC CROHN'S DISEASE
Journal of Pediatric Gastroenterology and Nutrition
Mohammed Hasosah and Anne Gomez and Gareth Jevon and Kevan Jacobson
DOI: 10.1097/00005176-200610000-00160
10/2006

Citrobacter rodentium infection causes both mitochondrial dysfunction and intestinal epithelial barrier disruption in vivo: role of mitochondrial associated protein (Map).
Cellular microbiology
Ma C and Wickham ME and Guttman JA and Deng W and Walker J and Madsen KL and Jacobson K and Vogl WA and Finlay BB and Vallance BA
DOI: 10.1111/j.1462-5822.2006.00741.x
PubMed: 16759225
10/2006

The Congenital Intrahepatic Arterioportal Fistula Syndrome
Journal of Pediatric Gastroenterology and Nutrition
Seamus P. Norton and Kevan Jacobson and Stanley P. Moroz and Gordon Culham and Vicky Ng and Justine Turner and Philip John
DOI: 10.1097/01.mpg.0000221890.13630.ad
08/2006

Noradrenergic and cholinergic neural pathways mediate stress-induced reactivation of colitis in the rat
Autonomic Neuroscience
Paul R. Saunders and Paula Miceli and Bruce A. Vallance and Lu Wang and Sarah Pinto and Gervais Tougas and Markad Kamath and Kevan Jacobson
DOI: 10.1016/j.autneu.2005.12.002
01/2006

A Randomized Trial of Yoga for Adolescents with Irritable Bowel Syndrome
Pain Research and Management
Leora Kuttner and Christine T Chambers and Janine Hardial and David M Israel and Kevan Jacobson and Kathy Evans
DOI: 10.1155/2006/731628
2006

Clinical Quiz
Journal of Pediatric Gastroenterology and Nutrition
T G Lokesh Babu and Kevan Jacobson
DOI: 10.1097/01.mpg.0000147132.59353.b9
11/2005

THE CHANGING PATTERN OF PEDIATRIC IBD AT BRITISH COLUMBIA CHILDRENS HOSPITAL
Journal of Pediatric Gastroenterology and Nutrition
Vered Pinsk and Daniel A Lemberg and Collin Barker and Richard Schreiber and David M Israel and Kevan Jacobson
DOI: 10.1097/01.mpg.0000182024.84053.a4
10/2005

Pediatric Inflammatory Bowel Disease: The British Columbia Experience
Journal of Pediatric Gastroenterology and Nutrition
Vered Pinsk and Daniel A Lemberg and Rosario Leonor and Collin Barker and Richard Schreiber and David M Israel and Kevan Jacobson
DOI: 10.1097/01.mpg.0000182025.84053.ed
10/2005

Positron Emission Tomography in the Investigation of Pediatric Inflammatory Bowel Disease
Inflammatory Bowel Diseases
Daniel A Lemberg and Robert M Issenman and Ruth Cawdron and Tim Green and John Mernagh and Stephen J Skehan and Claude Nahmias and Kevan Jacobson
DOI: 10.1097/01.mib.0000172810.49619.cb
08/2005

Endoscopic Hemostasis in a Neonate with a Bleeding Duodenal Ulcer
Journal of Pediatric Gastroenterology and Nutrition
T G Lokesh Babu and Kevan Jacobson and Min Phang and Mark R Riley and Collin C Barker
DOI: 10.1097/01.mpg.0000173602.39271.ff
08/2005

Intestinal responsiveness to experimental colitis in young rats is altered by maternal diet
American Journal of Physiology-Gastrointestinal and Liver Physiology
Kevan Jacobson and Harmeet Mundra and Sheila M. Innis
DOI: 10.1152/ajpgi.00459.2004
07/2005

Canadian Helicobacter Study Group Consensus Conference: Update on the approach to Helicobacter pylori infection in children and adolescents--an evidence-based evaluation.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie
Bourke B and Ceponis P and Chiba N and Czinn S and Ferraro R and Fischbach L and Gold B and Hyunh H and Jacobson K and Jones NL and Koletzko S and Lebel S and Moayyedi P and Ridell R and Canadian Helicobacter Study Group
PubMed: 16010300
07/2005

Myenteric plexus injury and apoptosis in experimental colitis
Autonomic Neuroscience
Lee Boyer and Mehran Ghoreishi and Valerie Templeman and Bruce A. Vallance and Alison M. Buchan and Gareth Jevon and Kevan Jacobson
DOI: 10.1016/j.autneu.2004.10.006
01/2005

The Changing Prevalence of Helicobacter Pylori Infection in Canadian Children: Should Screening Be Performed in High-Risk Children?
Canadian Journal of Gastroenterology
Kevan Jacobson
DOI: 10.1155/2005/840909
2005

Canadian Helicobacter Study Group Consensus Conference: Update on the Approach to Helicobacter Pylori Infection in Children and Adolescents – an Evidence-Based Evaluation
Canadian Journal of Gastroenterology
Nicola L Jones and Philip Sherman and Carlo A Fallone and Nigel Flook and Fiona Smaill and Sander Veldhuyzen van Zanten and Richard Hunt and Alan Thomson and Canadian Helicobacter Study Group
DOI: 10.1155/2005/390932
2005

Cytomegalovirus-Associated Hemophagocytic Syndrome in a Child With Crohn Disease Receiving Azathioprine
Journal of Pediatric Gastroenterology and Nutrition
T. G. Lokesh Babu and Dana Boctor and Alyson Davey and Mason C. Bond and Kevan Jacobson
DOI: 10.1097/00005176-200410000-00020
10/2004

Say Goodbye and Say Hello: The Transition from Pediatric to Adult Gastroenterology
Canadian Journal of Gastroenterology
Jorge L Pinzon and Kevan Jacobson and John Reiss
DOI: 10.1155/2004/474232
2004

Canadian Helicobacter Study Group Consensus Conference: Update on the Management ofHelicobacter pylori- An Evidence-Based Evaluation of Six Topics Relevant to Clinical Outcomes in Patients Evaluated forH pyloriInfection
Canadian Journal of Gastroenterology
Richard Hunt and Carlo Fallone and Sander Veldhuyzan van Zanten and Phil Sherman and Fiona Smaill and Nigel Flook and Alan Thomson and all participants of CHSG 2004
DOI: 10.1155/2004/326767
2004

Curcumin attenuates DNB-induced murine colitis.
American journal of physiology. Gastrointestinal and liver physiology
Salh B and Assi K and Templeman V and Parhar K and Owen D and Gómez-Muñoz A and Jacobson K
DOI: 10.1152/ajpgi.00449.2002
PubMed: 12637253
07/2003

Host susceptibility to the attaching and effacing bacterial pathogen Citrobacter rodentium.
Infection and immunity
Vallance BA and Deng W and Jacobson K and Finlay BB
DOI: 10.1128/iai.71.6.3443-3453.2003
PubMed: 12761129
06/2003

Comparison of Multidetector CT and Barium Studies of the Small Bowel:Inflammatory Bowel Disease in Children
American Journal of Roentgenology
Douglas H. Jamieson and Peter J. Shipman and David M. Israel and Kevan Jacobson
DOI: 10.2214/ajr.180.5.1801211
05/2003

Neutrophil granulocytes mediate enteric nervous system injury in a murine model of colitis
Gastroenterology
Kevan Jacobson and Lee C. Boyer and Mehran Ghoreishi and Valerie Templeman and Bruce A. Vallance and Gareth Jevon
DOI: 10.1016/s0016-5085(03)81636-0
04/2003

Cholinergic pathways modulate experimental dinitrobenzene sulfonic acid colitis in rats
Autonomic Neuroscience
P.C Miceli and K Jacobson
DOI: 10.1016/s1566-0702(03)00023-7
04/2003

Esophageal Crohn Disease in Children: A Clinical Spectrum
Journal of Pediatric Gastroenterology and Nutrition
Kannan Ramaswamy and Kevan Jacobson and Gareth Jevon and David Israel
DOI: 10.1097/00005176-200304000-00006
04/2003

Modulation of inducible nitric oxide synthase expression by the attaching and effacing bacterial pathogen citrobacter rodentium in infected mice.
Infection and immunity
Vallance BA and Deng W and De Grado M and Chan C and Jacobson K and Finlay BB
DOI: 10.1128/iai.70.11.6424-6435.2002
PubMed: 12379723
11/2002

Etiology of dyspepsia: implications for empirical therapy
Canadian Journal of Gastroenterology
09/2002

EVIDENCE-BASED FEEDING GUIDELINES FOR VERY LOW-BIRTH-WEIGHT INFANTS
Advances in Neonatal Care
SHAHIROSE S. PREMJI and BOSCO PAES and KEVAN JACOBSON and LORRAINE CHESSELL
DOI: 10.1053/adnc.2002.31511
02/2002

A matched cohort study of feeding practice guidelines for infants weighing less than 1,500g
Advances in Neonatal Care
SHAHIROSE S. PREMJI and LORRAINE CHESSELL and BOSCO PAES and JANET PINELLI and KEVAN JACOBSON
DOI: 10.1053/adnc.2002.31510
02/2002

Epstein-Barr Virus Infection in Transplant Recipients: Sumary of a Workshop on Surveillance, Prevention and Treatment
Canadian Journal of Infectious Diseases
Upton Allen and Caroline Alfieri and Jutta Preiksaitis and Atul Humar and Dorothy Moore and Bruce Tapiero and Raymond Tellier and Michael Green and Dele Davies and Diane Hébert and Sheila Weitzman and Martin Petric and Kevan Jacobson and Canadian PTLD Workshop Group #x2013; 1999
DOI: 10.1155/2002/634318
2002

The changing face of celiac disease
Paediatrics & Child Health
Rameeta Lad and Kevan Jacobson
DOI: 10.1093/pch/6.9.644
11/2001

INFECTIOUS DIARRHEA IN CHILDREN
Gastroenterology Clinics of North America
Kannan Ramaswamy and Kevan Jacobson
DOI: 10.1016/s0889-8553(05)70201-6
09/2001

Development of interstitial cells of Cajal in a full-term infant without an enteric nervous system
Gastroenterology
Jan D. Huizinga and Irene Berezin and Kanishka Sircar and Bryan Hewlett and Graeme Donnelly and Premysl Bercik and Catherine Ross and Talal Algofi and Peter Fitzgerald and Tara Der and Robert H. Riddell and Stephen M. Collins and Kevan Jacobson
DOI: 10.1053/gast.2001.21200
02/2001

Gastric Acid Secretory Response inHelicobacter pylori-Positive Patients with Duodenal Ulcer Disease
Canadian Journal of Gastroenterology
Kevan Jacobson and Naoki Chiba and Ying Chen and Miguel Barrientos and Cindy James and Robert H Riddell and Richard H Hunt
DOI: 10.1155/2001/764615
2001

Stress reactivation colitis and the role of the autonomic nervous system (ANS)
Gastroenterology
Paul Saunders and Markad Kamath and Kevan Jacobson
DOI: 10.1016/s0016-5085(00)85664-4
04/2000

Autonomic nervous system (ANS) dysfunction exacerbates inflammation in dextran sulfate (DSS) model of ulcerative colitis
Gastroenterology
Paula C. Miceli and Paul Saunders and Veljko Djuric and Kevan Jacobson
DOI: 10.1016/s0016-5085(00)85665-6
04/2000

An Unusual Cause of Recurrent Pancreatitis: Duodenal Duplication Cyst
Canadian Journal of Gastroenterology
Rameeta J Lad and Peter Fitzgerald and Kevan Jacobson
DOI: 10.1155/2000/152809
2000

Omeprazole for treatment of chronic erosive esophagitis in children: A multicenter study of efficacy, safety, tolerability and dose requirements
The Journal of Pediatrics
Eric Hassall and David Israel and Ross Shepherd and Michael Radke and Agneta Dalväg and Birgitta Sköld and Ola Junghard and Per Lundborg
DOI: 10.1067/mpd.2000.109607
2000

18F-fluorodeoxyglucose positron tomography in diagnosis of paediatric inflammatory bowel disease
The Lancet
Robert Issenman and John Mernagh and Claude Nahmias and Kevan Jacobson and Stephen J Skehan
DOI: 10.1016/s0140-6736(99)80021-x
09/1999

CanadianHelicobacterStudy Group Consensus Conference on the Approach toHelicobacter PyloriInfection in Children and Adolescents
Canadian Journal of Gastroenterology
P Sherman and E Hassall and RH Hunt and CA Fallone and S Veldhuyzen van Zanten and ABR Thomson and Canadian Helicobacter Study Group
DOI: 10.1155/1999/934285
1999

Neuroimmune mechanisms in a rat model of stress-induced reactivation of experimental colitis
Gastroenterology
P.C. Miceli and B.A. Vallance and K. Jacobson
DOI: 10.1016/s0016-5085(98)84227-3
04/1998

Neuro-modulation of stress-induced reactivation of experimental colitis
Gastroenterology
P.C. Miceli and V. Djuric and K. Jacobson
DOI: 10.1016/s0016-5085(98)84734-3
04/1998

Patients’ Diets and Preferences in a Pediatric Population with Inflammatory Bowel Disease
Canadian Journal of Gastroenterology
Timothy J Green and Robert M Issenman and Kevan Jacobson
DOI: 10.1155/1998/928706
1998

The mechanism of altered neural function in a rat model of acute colitis.
Gastroenterology
Jacobson K and McHugh K and Collins SM
DOI: 10.1016/s0016-5085(97)70230-0
PubMed: 8978354
01/1997

Previous inflammation alters the response of the rat colon to stress
Gastroenterology
SM Collins and K McHugh and K Jacobson and I Khan and R Riddell and K Murase and HP Weingarten
DOI: 10.1016/s0016-5085(96)70012-4
1996

Experimental colitis alters myenteric nerve function at inflamed and noninflamed sites in the rat
Gastroenterology
Kevan Jacobson and Kevin McHugh and Stephen M. Collins
DOI: 10.1016/0016-5085(95)90378-x
09/1995

The selective beneficial effects of nitric oxide inhibition in experimental colitis.
The American journal of physiology
Hogaboam CM and Jacobson K and Collins SM and Blennerhassett MG
PubMed: 7537457
04/1995

Interpreting abnormalities in routine liver biochemistry
Canadian Family Physician
1992

Research

Current projects
Epidemiology of paediatric IBD

Current Projects
Examining the role of maternal dietary lipid in modulating epithelial barrier function and intestinal immune response of the young offspring to chemically induced colitis

Current Projects
Determining the effect of intestinal inflammation on neuro-epithelial function in animal models of IBD

Honours & Awards

Canadian Children Inflammatory Bowel Disease Network, CIHR and CH.I.L.D Foundation – 2013

Research Group Members

Justin Chan, Graduate Research Assistant
George Evans, Honorary Research Associate
Alice Foster
Genelle Healey, Postdoctoral Fellow
Laura Meleady, Research Assistant
Mielle Michaux, Graduate Student
Isaac Rodin, Volunteer
Sandy Wu, Research Manager
Manaswi Yerrabattini, Co Op Student
Hongbing Yu, Research Associate