Selected Publications from Dr. Pascal Lavoie 

For a complete pubmed list click here

Rethinking management of neonates at risk of sepsis. Lavoie PM, Popescu CR, Molyneux EM, Wynn JL, Chiume M, Keitel K, Lufesi N, Levine GA, Ansermino JM, Kissoon N. Lancet. 2019 Jul 27;394(10195):279-281.

Outcomes related to respiratory syncytial virus with an abbreviated palivizumab regimen in children with congenital heart disease: a descriptive analysis. Claydon J, Popescu CR, Shaiba L, Christopherson C, Human D, Taylor R, Solimano A, Lavoie PM. CMAJ Open. 2019 Feb 18;7(1):E88-E93.

Cellular metabolism constrains innate immune responses in early human ontogeny. Kan B, Michalski C, Fu H, Au HHT, Lee K, Marchant EA, Cheng MF, Anderson-Baucum E, Aharoni-Simon M, Tilley P, Mirmira RG, Ross CJ, Luciani DS, Jan E, Lavoie PM. Nat Commun. 2018 Nov 16;9(1):4822. 

A Time-Based Analysis of Inflammation in Infants at Risk of Bronchopulmonary Dysplasia. Leroy S, Caumette E, Waddington C, Hébert A, Brant R, Lavoie PM. J Pediatr. 2018 Jan;192:60-65.e1.

The phenotype and function of preterm infant monocytes: implications for susceptibility to infection. de Jong E, Strunk T, Burgner D, Lavoie PM, Currie A. J Leukoc Biol. 2017 Sep;102(3):645-656. 

Antifungal Immunological Defenses in Newborns. Michalski C, Kan B, Lavoie PM. Front Immunol. 2017 Mar 15;8:281.

An Immunological Perspective on Neonatal Sepsis. Kan B, Razzaghian HR, Lavoie PM. Trends Mol Med. 2016 Apr;22(4):290-302.

Outcomes of Respiratory Syncytial Virus Immunoprophylaxis in Infants Using an Abbreviated Dosing Regimen of Palivizumab. Lavoie PM, Solimano A, Taylor R, Kwan E, Claydon J, Turvey SE, Marr N. JAMA Pediatr. 2016 Feb;170(2):174-6. 

Attenuated innate immune defenses in very premature neonates during the neonatal period. Marchant EA, Kan B, Sharma AA, van Zanten A, Kollmann TR, Brant R, Lavoie PM. Pediatr Res. 2015 Nov;78(5):492-7.

Impaired NLRP3 inflammasome activity during fetal development regulates IL-1β production in human monocytes. Sharma AA, Jen R, Kan B, Sharma A, Marchant E, Tang A, Gadawski I, Senger C, Skoll A, Turvey SE, Sly LM, Côté HC, Lavoie PM. Eur J Immunol. 2015 Jan;45(1):238-49.

Hierarchical maturation of innate immune defences in very preterm neonates. Sharma AA, Jen R, Brant R, Ladd M, Huang Q, Skoll A, Senger C, Turvey SE, Marr N, Lavoie PM. Neonatology. 2014;106(1):1-9.

Attenuation of respiratory syncytial virus-induced and RIG-I-dependent type I IFN responses in human neonates and very young children. Marr N, Wang TI, Kam SH, Hu YS, Sharma AA, Lam A, Markowski J, Solimano A, Lavoie PM, Turvey SE. J Immunol. 2014 Feb 1;192(3):948-57. 

Neonatal sepsis due to coagulase-negative staphylococci. Marchant EA, Boyce GK, Sadarangani M, Lavoie PM. Clin Dev Immunol. 2013;2013:586076. 

The developing human preterm neonatal immune system: a case for more research in this area.
Sharma AA, Jen R, Butler A, Lavoie PM. Clin Immunol. 2012 Oct;145(1):61-8.

Early inflammation in the absence of overt infection in preterm neonates exposed to intensive care.
Chang BA, Huang Q, Quan J, Chau V, Ladd M, Kwan E, McFadden DE, Lacaze-Masmonteil T, Miller SP, Lavoie PM. Cytokine. 2011 Dec;56(3):621-6.

Ontogeny of Toll-like receptor mediated cytokine responses of human blood mononuclear cells. Corbett NP, Blimkie D, Ho KC, Cai B, Sutherland DP, Kallos A, Crabtree J, Rein-Weston A, Lavoie PM, Turvey SE, Hawkins NR, Self SG, Wilson CB, Hajjar AM, Fortuno ES 3rd, Kollmann TR. PLoS One. 2010 Nov 30;5(11):e15041. 

Profound lack of interleukin (IL)-12/IL-23p40 in neonates born early in gestation is associated with an increased risk of sepsis. Lavoie PM, Huang Q, Jolette E, Whalen M, Nuyt AM, Audibert F, Speert DP, Lacaze-Masmonteil T, Soudeyns H, Kollmann TR. J Infect Dis. 2010 Dec 1;202(11):1754-63. 
Inflammatory response in preterm infants is induced early in life by oxygen and modulated by total parenteral nutrition. Lavoie PM, Lavoie JC, Watson C, Rouleau T, Chang BA, Chessex P. Pediatr Res. 2010 Sep;68(3):248-51.