My research focuses on development and improvement of biochemical laboratory measures for improved diagnoses of both maternal and neonatal health issues.


Comparative evaluation of neonatal bilirubin using Radiometer whole blood co-oximetry and plasma bilirubin methods from Roche Diagnostics and Ortho Clinical Diagnostics
Clinical Biochemistry
Ian Marie Lano and Andrew W. Lyon and Li Wang and Rob Ruskin and Martha E. Lyon
DOI: 10.1016/j.clinbiochem.2017.12.009

Limitations and opportunities of whole blood bilirubin measurements by GEM premier 4000®
BMC Pediatrics
Li Wang and Arianne Y. K. Albert and Benjamin Jung and Keyvan Hadad and Martha E. Lyon and Melanie Basso
DOI: 10.1186/s12887-017-0842-8

Visual or automated dipstick testing for proteinuria in pregnancy?
Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health
Mauricio E. Correa and Anne-Marie Côté and Dane A. De Silva and Li Wang and Prianthiny Packianathan and Peter von Dadelszen and Laura A. Magee
DOI: 10.1016/j.preghy.2017.01.005

Acute encephalopathy in a kidney transplant recipient following infusion of intravenous immunoglobulin
Transplant Intern 2014 Nov; 27 (11):e115-7.
DOI: 10.1111/tri.12384
PubMed: 24964219

Hematocrit correction does not improve glucose monitor accuracy in the assessment of neonatal hypoglycemia.
Clinical chemistry and laboratory medicine
DOI: 10.1515/cclm-2012-0436
PubMed: 23420286

Measurement uncertainty for serum free light chain assays: estimation and implication on result interpretation
Clinical Biochemistry
DOI: 10.1016/j.clinbiochem.2012.11.015
PubMed: 23200885

Assessing pneumatic tube systems with patient-specific populations and laboratory-derived criteria.
Clinical chemistry
DOI: 0.1373/clinchem.2011.179044
PubMed: 22291142

Roche acetaminophen assay negative bias at low concentrations is imprvoved using the TDM diluent as the zero calibrator
Clinical Biochemistry
P. Kavsak and N. Wakefied and L. Clark and L. Lyko and R. Pickersgill and L. Wang and J. Zeidler
DOI: 10.1016/j.clinbiochem.2010.04.026

Pediatric critical values: Laboratory–pediatrician discourse
Clinical Biochemistry
Andrew C. Don-Wauchope and Li Wang and Vijaylaxmi Grey
DOI: 10.1016/j.clinbiochem.2009.06.029

Rescue of Munc18-1 and -2 Double Knockdown Reveals the Essential Functions of Interaction between Munc18 and Closed Syntaxin in PC12 Cells
Molecular Biology of the Cell
L. Han and T. Jiang and G. A. Han and N. T. Malintan and L. Xie and L. Wang and F. W. Tse and H. Y. Gaisano and B. M. Collins and F. A. Meunier and S. Sugita
DOI: 10.1091/mbc.e09-08-0712

RalA and RalB Function as the Critical GTP Sensors for GTP-Dependent Exocytosis
Journal of Neuroscience
G. Li and L. Han and T.-C. Chou and Y. Fujita and L. Arunachalam and A. Xu and A. Wong and S.-K. Chiew and Q. Wan and L. Wang and S. Sugita
DOI: 10.1523/jneurosci.2537-06.2007

N-Terminal Insertion and C-Terminal Ankyrin-Like Repeats of  -Latrotoxin Are Critical for Ca2+-Dependent Exocytosis
Journal of Neuroscience
G. Li
DOI: 10.1523/jneurosci.3560-05.2005

A Central Kinase Domain of Type I Phosphatidylinositol Phosphate Kinases Is Sufficient to Prime Exocytosis: ISOFORM SPECIFICITY AND ITS UNDERLYING MECHANISM
Journal of Biological Chemistry
L. Wang and G. Li and S. Sugita
DOI: 10.1074/jbc.m413263200

RalA-Exocyst Interaction Mediates GTP-dependent Exocytosis
Journal of Biological Chemistry
Li Wang and Gang Li and Shuzo Sugita
DOI: 10.1074/jbc.m400522200


Current Projects
Whole blood measurement of bilirubin: Bilirubin is routinely measured in infants before discharge to screen for hyperbilirubinemia (jaundice). Early detection prevents brain damage that may occur with high levels of bilirubin. I am currently investigating new methods to assess bilirubin with whole blood. This project compares whole blood bilirubin measurement to plasma bilirubin measurement to verify accuracy, efficiency and quality and assess factors which might interfere with the whole blood method. If successful, this will enable assessment using much smaller blood sample volumes and producing faster results at the point of care.

Biomarkers of preeclampsia: Early diagnosis of preeclampsia can potentially prevent some of the adverse outcomes associated with this disease. However, early diagnosis of this disease is currently limited by a lack of clinical tests in this area. There is increasing evidence that an enzyme that breaks down tryptophan, an amino acid essential in the diet, is involved in the development of preeclampsia. I am assessing the levels of tryptophan and its metabolites in maternal blood to see whether they can be used to identify patients with preeclampsia in the second trimester of pregnancy before preeclampsia would typically be diagnosed. The development of a new test to predict preeclampsia and its complications will help clinicians provide an accurate diagnosis early in pregnancy and modify patient care accordingly, thus allowing them to provide the best care for both mothers and babies.


Ultra performance liquid chromatography-Tandem mass spectrometry (UPLC-MS/MS) determination of tryptophan and kynurenines in urine and plasma samples. Resident Research Grant, Department of Pathology & Molecular Medicine, McMaster University (2011).

Evaluation of the role of maternal tryptophan and kynurenine pathway metabolites in early diagnosis of preeclampsia. Clinical Translational Research Seed Grant, Child & Family Research Institute (2014-2015).

Research Group Members

Maria Huicochea Munoz, Student RA