The Maxwell Lab collaborates with leading research teams located around the world. Together, we work on research projects related to oriented cell division and hereditary cancers, HMMR and BRCA1 biology, and personalized pediatric oncology. A complete list of Maxwell’s publications can be found on ORCID

Selected publications

  1. Morris EJ†, Gillepsie JA, Maxwell CA†, Dedhar S†. A model of differential mammary growth initiation by Stat3 and asymmetric Integrin-a6 inheritance. Cell Reports. 2020, 17; 30(11): 3605-3615.e5. PMID: 32187533 (†co-senior authors)
  2. Fulcher LJ, He Z, Mei L, Macartney TJ, Wood NT, Prescott AR, Whigham AJ, Varghese J, Gourlay R, Ball G, Clarke R, Campbell DG, Maxwell CA, Sapkota GP. FAM83D directs protein kinase CK1alpha to the mitotic spindle for proper spindle positioning. EMBO Reports. 2019, 20(9): e47495. PMID: 31338967 
  3. Lorentzian A, Biegel JA, Ostrow DG, Rolf N, Liu CC, Rassekh SR, Deyell RJ, Triche T, Schultz K, Rozmus J, Reid GSD, Lim CJ, Lange PF†, Maxwell CA†. Tumor variant identification that accounts for the unique molecular landscape of pediatric malignancies. JNCI Cancer Spectrum. 2019, 2(4): pky079. PMID: 30976750 (†co-senior authors)
  4. Chen H, Connell M, Reid GSD, Maxwell CA. The non-motor adaptor HMMR dampens Eg5-mediated forces to preserve the kinetics and integrity of division. Molecular Biology of the Cell. 2018, 29 (7): 786-796. PMID: 29386294
  5. Chu TLH*, Connell M*, Zhou L, He Z, Won JR, Rahavi SM, Chen H, Mohan P, Nemirovsky O, Fotovati A, Pujana MA, Reid GSD, Nielson TO, Pante N, Maxwell CA. Cell cycle-dependent tumor engraftment and cell migration are enabled by Aurora A. Molecular Cancer Research. 2018,16(1):16-31. PMID: 28993511 (co-first authors) 
  6. Connell M*, Chen H*, Jiang J, Kuan CW, Fotovati A, Chu T, He Z, Lengyell TC, Li H, Kroll T, Li AM, Goldowitz D, Frappart L, Ploubidou A, Patel M, Pilarski LM, Simpson EM, Lange P, Allan DW, Maxwell CA. HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development. eLife. 2017,10;6 pii: e28672. PMID: 28994651
  7. He Z*, Kannan N*, Nemirovsky O, Chen H, Connell M, Taylor BJ, Jiang J, Pilarski LM, Fleisch MC, Niederacher D, Pujana MA, Eaves CJ†, Maxwell CA†. BRCA1 controls the cell division axis and governs ploidy and phenotype in human mammary cells. Oncotarget. 2017, 8(20):32461-32475. PMID: 28427147 (†co-senior authors, *co-first authors).
  8. Chen H, Mohan P, Jiang J, Nemirovsky O, He D, Fleisch MC, Niederarcher D, Pilarski LM, Lim CJ, Maxwell CA. Spatial regulation of Aurora A activity during mitotic spindle assembly requires RHAMM to correctly localize TPX2. Cell Cycle. 2014, 13(14): 2248-061. PMID: 24875404
  9. Davies AH, Reipas KM, Fotovati A, Pambid MR, Stratford A, Hu K, Maxwell C, Mills G, Dunn SE. YB-1 promotes tumor-initiation through chromatin remodeling leading to the development of basal-like breast cancer. Stem Cells. 2014, 32(6):1437-50. PMID: 24648416
  10. Ferrer I*, Mohan P*, Chen H, Castellague J, Gomez-Baldo L, Carmona M, Fernandez-Taboada E, Garcia N, Jiang J, Aguilar H, Skowron M, Nellist M, Astrinidis A, Hartley S, Valianou M, Ampuero I, Russi A, Lazaro C, Maxwell CA†, Pujana MA†. Tubers from patients with Tuberous Sclerosis Complex are characterized by changes in microtubule nucleation capacity through ROCK2 signaling. Journal of Pathology. 2014, 23: 247-57. PMID: 24604753 (†co-senior authors, *co-first authors).
  11. Jiang J, Mohan P, Maxwell CA. The cytoskeletal protein RHAMM and ERK1/2 activity maintain the pluripotency of murine embryonic stem cells. PLoS One. 2013, 8: e73548. PMID: 24019927
  12. Mohan P, Castellsague J, Jiang J, Allen K, Chen H, Nemirovsky O, Spyra M, Hu K, Kluwe L, Pujana MA, Villanueva A, Mautner VF, Keats JJ, Dunn SE, Lazaro C, Maxwell CA. Genomic imbalance of HMMR/RHAMM regulates the sensitivity and response of malignant peripheral nerve sheath tumour cells to aurora kinase inhibition. Oncotarget. 2013, 4, 70-83. PMID: 23328114 
  13. Davies AH, Barrett I, Pambid MR, Hu K, Stratford AL, Freeman S, Berquin IM, Pelech S, Hieter P, Maxwell C, Dunn SE. YB-1 evokes susceptibility to cancer through cytokinesis failure, mitotic dysfunction and HER2 amplification. Oncogene. 2011, 30, 3649-60. PMID: 21423216
  14. Maxwell CA†, …, Pujana MA†. Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. PLoS Biology. 2011, 11, e1001199. PMID: 22110403 (†co-senior authors)

    Reviews and commentary
     
  15. Wang S, Maxwell CA†, Akella NM†. Diet as a potential moderator for genome stability and immune response in childhood leukemia. Cancers. 2021, 13, 413. PMID: 33499176 (†co-senior authors)
  16. He Z, L Mei, Connell M, Maxwell CA. Hyaluronan Mediated Motility Receptor (HMMR) Encodes an Evolutionarily Conserved Homeostasis, Mitosis, and Meiosis Regulator Rather Than a Hyaluronan Receptor. Cells. 2020, 28;9(4):819. PMID: 32231069
  17. van Netten JP†, Cann SH, Thornton I, Finegan RP, Maxwell CA. Anti-angiogenic treatment for breast cancer? Cancer Treatment Reviews. 2017, 55: 230. PMID: 28320564
  18. Ferguson LR†, …, Maxwell CA†. Genomic instability in human cancer: molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition. Seminars in Cancer Biology. 2015, 35 Suppl: S5- S24. PMID: 25869442 (†co-senior authors)