The Maxwell Lab collaborates with leading research teams located around the world. Together, we work on research projects related to oriented cell division and hereditary cancers, HMMR and BRCA1 biology, and personalized pediatric oncology. A complete list of Maxwell’s publications can be found on ORCID

Selected recent publications

He Z, Ghorayeb R, Tan S, Chen K, Lorentzian A, Bottyan J, Aalam SMM, Pujana MA, Lange PF, Kannan N, Eaves CJ, Maxwell CA.
Pathogenic BRCA1 mutations disturb the PLK1-dependent mitotic spindle orientation pathway.
Nature Communications. 2022, 13:2200 (PMID: 35459234)

Mateo F*, He Z*, Mei L* (*co-first authors), Ruiz de Garibay G, Herranz C, García N, Lorentzian A, Baigés A, Blommaert E, Gómez A, Mirallas O, Garrido-Utrilla A, Palomero L, Espín R, Extremera AI, Soler Monso T, Petit A, Li R, Brunet J, Chen K, Tan S, Eaves CJ, McCloskey C, Hakem R, Khokha R, Lange PF, Lázaro C, Maxwell CA† and Pujana MA† (†co-senior authors).
Modification of BRCA1-associated cancer risk by HMMR overexpression.
Nature Communications. 2022, 13(1):1895. PMID: 35393420

Morris EJ†, Gillepsie JA, Maxwell CA†, Dedhar S†. (†co-senior authors)
A model of differential mammary growth initiation by Stat3 and asymmetric Integrin-a6 inheritance
Cell Reports. 2020, 17; 30(11): 3605-3615.e5. PMID: 32187533

Fulcher LJ, He Z, Mei L, Macartney TJ, Wood NT, Prescott AR, Whigham AJ, Varghese J, Gourlay R, Ball G, Clarke R, Campbell DG, Maxwell CA, Sapkota GP.
FAM83D directs protein kinase CK1alpha to the mitotic spindle for proper spindle positioning.
EMBO Reports. 2019, 20(9): e47495. PMID: 31338967

Lorentzian A, Biegel JA, Ostrow DG, Rolf N, Liu CC, Rassekh SR, Deyell RJ, Triche T, Schultz K, Rozmus J, Reid GSD, Lim CJ, Lange PF†, Maxwell CA†. (†co-senior authors)
Tumor variant identification that accounts for the unique molecular landscape of pediatric malignancies.
JNCI Cancer Spectrum. 2019, 2(4): pky079. PMID: 30976750

Chen H, Connell M, Reid GSD, Maxwell CA.
The non-motor adaptor HMMR dampens Eg5-mediated forces to preserve the kinetics and integrity of division.
Molecular Biology of the Cell. 2018, 29 (7): 786-796. PMID: 29386294

Chu TLH*, Connell M* (*co-first authors), Zhou L, He Z, Won JR, Rahavi SM, Chen H, Mohan P, Nemirovsky O, Fotovati A, Pujana MA, Reid GSD, Nielson TO, Pante N, Maxwell CA
Cell cycle-dependent tumor engraftment and cell migration are enabled by Aurora A.
Molecular Cancer Research. 2018,16(1):16-31. PMID: 28993511

Connell M*, Chen H* (*co-first authors), Jiang J, Kuan CW, Fotovati A, Chu T, He Z, Lengyell TC, Li H, Kroll T, Li AM, Goldowitz D, Frappart L, Ploubidou A, Patel M, Pilarski LM, Simpson EM, Lange P, Allan DW, Maxwell CA.
HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development.
eLife. 2017,10;6 pii: e28672. PMID: 28994651

Selected recent reviews

Wang S, Maxwell CA†, Akella NM† (†co-senior authors).
Diet as a potential moderator for genome stability and immune response in childhood leukemia.
Cancers. 2021, 13, 413. PMID: 33499176

He Z, L Mei, Connell M, Maxwell CA.
Hyaluronan Mediated Motility Receptor (HMMR) Encodes an Evolutionarily Conserved Homeostasis, Mitosis, and Meiosis Regulator Rather Than a Hyaluronan Receptor.
Cells. 2020, 28;9(4):819. PMID: 32231069