The Maxwell Lab collaborates with leading research teams located around the world. Together, we work on research projects related to oriented cell division and hereditary cancers, HMMR and BRCA1 biology, and personalized pediatric oncology. A complete list of Maxwell’s publications can be found on ORCID.
Selected recent publications
He Z, Ghorayeb R, Tan S, Chen K, Lorentzian A, Bottyan J, Aalam SMM, Pujana MA, Lange PF, Kannan N, Eaves CJ, Maxwell CA.
Pathogenic BRCA1 mutations disturb the PLK1-dependent mitotic spindle orientation pathway.
Nature Communications. 2022, 13:2200 (PMID: 35459234)
Mateo F*, He Z*, Mei L* (*co-first authors), Ruiz de Garibay G, Herranz C, García N, Lorentzian A, Baigés A, Blommaert E, Gómez A, Mirallas O, Garrido-Utrilla A, Palomero L, Espín R, Extremera AI, Soler Monso T, Petit A, Li R, Brunet J, Chen K, Tan S, Eaves CJ, McCloskey C, Hakem R, Khokha R, Lange PF, Lázaro C, Maxwell CA† and Pujana MA† (†co-senior authors).
Modification of BRCA1-associated cancer risk by HMMR overexpression.
Nature Communications. 2022, 13(1):1895. PMID: 35393420
Morris EJ†, Gillepsie JA, Maxwell CA†, Dedhar S†. (†co-senior authors)
A model of differential mammary growth initiation by Stat3 and asymmetric Integrin-a6 inheritance.
Cell Reports. 2020, 17; 30(11): 3605-3615.e5. PMID: 32187533
Fulcher LJ, He Z, Mei L, Macartney TJ, Wood NT, Prescott AR, Whigham AJ, Varghese J, Gourlay R, Ball G, Clarke R, Campbell DG, Maxwell CA, Sapkota GP.
FAM83D directs protein kinase CK1alpha to the mitotic spindle for proper spindle positioning.
EMBO Reports. 2019, 20(9): e47495. PMID: 31338967
Lorentzian A, Biegel JA, Ostrow DG, Rolf N, Liu CC, Rassekh SR, Deyell RJ, Triche T, Schultz K, Rozmus J, Reid GSD, Lim CJ, Lange PF†, Maxwell CA†. (†co-senior authors)
Tumor variant identification that accounts for the unique molecular landscape of pediatric malignancies.
JNCI Cancer Spectrum. 2019, 2(4): pky079. PMID: 30976750
Chen H, Connell M, Reid GSD, Maxwell CA.
The non-motor adaptor HMMR dampens Eg5-mediated forces to preserve the kinetics and integrity of division.
Molecular Biology of the Cell. 2018, 29 (7): 786-796. PMID: 29386294
Chu TLH*, Connell M* (*co-first authors), Zhou L, He Z, Won JR, Rahavi SM, Chen H, Mohan P, Nemirovsky O, Fotovati A, Pujana MA, Reid GSD, Nielson TO, Pante N, Maxwell CA
Cell cycle-dependent tumor engraftment and cell migration are enabled by Aurora A.
Molecular Cancer Research. 2018,16(1):16-31. PMID: 28993511
Connell M*, Chen H* (*co-first authors), Jiang J, Kuan CW, Fotovati A, Chu T, He Z, Lengyell TC, Li H, Kroll T, Li AM, Goldowitz D, Frappart L, Ploubidou A, Patel M, Pilarski LM, Simpson EM, Lange P, Allan DW, Maxwell CA.
HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development.
eLife. 2017,10;6 pii: e28672. PMID: 28994651
Selected recent reviews
Wang S, Maxwell CA†, Akella NM† (†co-senior authors).
Diet as a potential moderator for genome stability and immune response in childhood leukemia.
Cancers. 2021, 13, 413. PMID: 33499176
He Z, L Mei, Connell M, Maxwell CA.
Hyaluronan Mediated Motility Receptor (HMMR) Encodes an Evolutionarily Conserved Homeostasis, Mitosis, and Meiosis Regulator Rather Than a Hyaluronan Receptor.
Cells. 2020, 28;9(4):819. PMID: 32231069