Overview

Ultrasound and invasive procedures (amniocentesis, chorionic villous sampling) are used to establish the fetus’s well being. My main research interest is to address the aspects of this process. Can we be more precise in counselling when diagnosing specific fetal anomalies? What are the impacts of associated anomalies?

There are unique aspects of the multiple pregnancy that need to be discussed at the time of the prenatal diagnosis counselling. I have reviewed the maternal and perinatal complications associated with triplet pregnancies at our institution, and amniocentesis for twin pregnancies. I have reviewed if we can use the level of amniotic fluid protein measured at the time of the amniocentesis to ensure that the procedure tested the two fetuses.

I am also involved in multicenter clinical trials. We are reviewing the use of antenatal steroids for prevention of morbidity associated with prematurity. A recently compiled study assessed the impact of doing external cephalic version at an earlier time in gestation on the caesarean section rate. The results are being analyzed.

Publications

Insuffisance cervicale et cerclage cervical.
Brown R, Gagnon R, Delisle MF
DOI: 10.1016/j.jogc.2016.09.046
PubMed: 28063549
12/2016

The Cost Implications in Ontario, Alberta, and British Columbia of Early Versus Delayed External Cephalic Version in the Early External Cephalic Version 2 (EECV2) Trial.
Ahmed RJ, Gafni A, Hutton EK, Early ECV2 Trial Collaborative Group
DOI: 10.1016/j.jogc.2015.12.019
PubMed: 27106193
03/2016

Fetal Outcomes of Prenatally Diagnosed Congenital Diaphragmatic Hernia: Nine Years of Clinical Experience in a Canadian Tertiary Hospital.
Oh T, Chan S, Kieffer S, Delisle MF
DOI: 10.1016/j.jogc.2015.10.006
PubMed: 26872751
01/2016

The role of cerclage beyond 24 weeks of gestation.
Brown R, Gagnon R, Delisle MF
PubMed: 25375297
10/2014

Association between gestational age at birth, antenatal corticosteroids, and outcomes at 5 years: multiple courses of antenatal corticosteroids for preterm birth study at 5 years of age (MACS-5).
Asztalos E, Willan A, Murphy K, Matthews S, Ohlsson A, Saigal S, Armson A, Kelly E, Delisle MF, Gafni A, Lee S, Sananes R, Rovet J, Guselle P, Amankwah K, MACS-5 Collaborative Group
DOI: 10.1186/1471-2393-14-272
PubMed: 25123162
08/2014

Cervical insufficiency and cervical cerclage.
Brown R, Gagnon R, Delisle MF, Maternal Fetal Medicine Committee, Gagnon R, Bujold E, Basso M, Bos H, Brown R, Cooper S, Crane J, Davies G, Gouin K, Menticoglou S, Mundle W, Pylypjuk C, Roggensack A, Sanderson F, Senikas V, Society of Obstetricians and Gynaecologists of Canada
PubMed: 24405880
12/2013

Multiple courses of antenatal corticosteroids for preterm birth study: outcomes in children at 5 years of age (MACS-5).
Asztalos EV, Murphy KE, Willan AR, Matthews SG, Ohlsson A, Saigal S, Armson BA, Kelly EN, Delisle MF, Gafni A, Lee SK, Sananes R, Rovet J, Guselle P, Amankwah K, Saleem M, Sanchez J, MACS-5 Collaborative Group
DOI: 10.1001/jamapediatrics.2013.2764
PubMed: 24126948
12/2013

Intrauterine growth restriction: screening, diagnosis, and management.
Lausman A, Kingdom J, Maternal Fetal Medicine Committee, Gagnon R, Basso M, Bos H, Crane J, Davies G, Delisle MF, Hudon L, Menticoglou S, Mundle W, Ouellet A, Pressey T, Pylypjuk C, Roggensack A, Sanderson F
PubMed: 24007710
08/2013

Effect of antenatal corticosteroids on fetal growth and gestational age at birth.
Murphy KE, Willan AR, Hannah ME, Ohlsson A, Kelly EN, Matthews SG, Saigal S, Asztalos E, Ross S, Delisle MF, Amankwah K, Guselle P, Gafni A, Lee SK, Armson BA, Multiple Courses of Antenatal Corticosteroids for Preterm Birth Study Collaborative Group
DOI: 10.1097/aog.0b013e31825189dc
PubMed: 22525902
05/2012

Prediction of pediatric outcome after prenatal diagnosis and expectant antenatal management of congenital cystic adenomatoid malformation.
Yong PJ, Von Dadelszen P, Carpara D, Lim K, Kent N, Tessier F, Delisle MF, Wong T, Blair G, Skarsgard ED
DOI: 10.1159/000331936
PubMed: 22310905
2012

In Utero diagnosis and management of a fetus with homozygous a-Thalassemia in the second trimester: a case report and literature review.
Dwinnell SJ, Coad S, Butler B, Albersheim S, Wadsworth LD, Wu JK, Delisle MF
DOI: 10.1097/mph.0b013e31821b368c
PubMed: 22042285
12/2011

Maternal side-effects after multiple courses of antenatal corticosteroids (MACS): the three-month follow-up of women in the randomized controlled trial of MACS for preterm birth study.
Murphy KE, Hannah ME, Willan AR, Ohlsson A, Kelly EN, Matthews SG, Saigal S, Asztalos E, Ross S, Delisle MF, Tomat L, Amankwah K, Guselle P, Gafni A, Lee SK, Armson BA, MACS Collaborative Group
PubMed: 21923988
09/2011

The Early External Cephalic Version (ECV) 2 Trial: an international multicentre randomised controlled trial of timing of ECV for breech pregnancies.
Hutton EK, Hannah ME, Ross SJ, Delisle MF, Carson GD, Windrim R, Ohlsson A, Willan AR, Gafni A, Sylvestre G, Natale R, Barrett Y, Pollard JK, Dunn MS, Turtle P, Early ECV2 Trial Collaborative Group
DOI: 10.1111/j.1471-0528.2010.02837.x
PubMed: 21291506
04/2011

Multiple courses of antenatal corticosteroids for preterm birth study: 2-year outcomes.
Asztalos EV, Murphy KE, Hannah ME, Willan AR, Matthews SG, Ohlsson A, Kelly EN, Saigal S, Ross S, Delisle MF, Amankwah K, Guselle P, Gafni A, Lee SK, Armson BA, Sananes R, Tomat L, Multiple Courses of Antenatal Corticosteroids for Preterm Birth Study Collaborative Group
DOI: 10.1542/peds.2010-0857
PubMed: 20956409
11/2010

SOGC Clinical Practice Guidelines: Obesity in pregnancy. No. 239, February 2010.
Davies GA, Maxwell C, McLeod L, Gagnon R, Basso M, Bos H, Delisle MF, Farine D, Hudon L, Menticoglou S, Mundle W, Murphy-Kaulbeck L, Ouellet A, Pressey T, Roggensack A, Leduc D, Ballerman C, Biringer A, Duperron L, Jones D
DOI: 10.1016/j.ijgo.2010.03.008
PubMed: 20641146
08/2010

[Cytomegalovirus infection in pregnancy].
Yinon Y, Farine D, Yudin MH, Gagnon R, Hudon L, Basso M, Bos H, Delisle MF, Menticoglou S, Mundle W, Ouellet A, Pressey T, Roggensack A, Boucher M, Castillo E, Gruslin A, Money DM, Murphy K, Ogilvie G, Paquet C
PubMed: 20500944
04/2010

Cytomegalovirus infection in pregnancy.
Yinon Y, Farine D, Yudin MH, Gagnon R, Hudon L, Basso M, Bos H, Delisle MF, Menticoglou S, Mundle W, Ouellet A, Pressey T, Roggensack A, Boucher M, Castillo E, Gruslin A, Money DM, Murphy K, Ogilvie G, Paquet C
PubMed: 20500943
04/2010

Obesity in pregnancy.
Davies GA, Maxwell C, McLeod L, Gagnon R, Basso M, Bos H, Delisle MF, Farine D, Hudon L, Menticoglou S, Mundle W, Murphy-Kaulbeck L, Ouellet A, Pressey T, Roggensack A, Leduc D, Ballerman C, Biringer A, Duperron L, Jones D
PubMed: 20181319
02/2010

SOGC CLINICAL PRACTICE GUIDELINE: guidelines for the management of vasa previa.
Gagnon R, Morin L, Bly S, Butt K, Cargil YM, Denis N, Hietala-Coyle MA, Lim KI, Ouellet A, Racicot MH, Salem S, Hudon L, Basso M, Bos H, Delisle MF, Farine D, Grabowska K, Menticoglou S, Mundle W, Murphy-Kaulbeck L
DOI: 10.1016/j.ijgo.2009.09.011
PubMed: 20050202
01/2010

SOGC clinical practice guideline: Vaginal delivery of breech presentation: no. 226, June 2009.
Kotaska A, Menticoglou S, Gagnon R, Farine D, Basso M, Bos H, Delisle MF, Grabowska K, Hudon L, Mundle W, Murphy-Kaulbeck L, Ouellet A, Pressey T, Roggensack A, Society of Obstetricians and Gynaecologists of Canada
DOI: 10.1016/j.ijgo.2009.07.002
PubMed: 19824190
11/2009

Antibiotic therapy in preterm premature rupture of the membranes.
Yudin MH, van Schalkwyk J, Van Eyk N, Boucher M, Castillo E, Cormier B, Gruslin A, Money DM, Murphy K, Ogilvie G, Paquet C, Steenbeek A, Wong T, Gagnon R, Hudon L, Basso M, Bos H, Delisle MF, Farine D, Grabowska K
PubMed: 19941711
09/2009

Guidelines for the management of vasa previa.
Gagnon R, Morin L, Bly S, Butt K, Cargill YM, Denis N, Hietala-Coyle MA, Lim KI, Ouellet A, Raciot MH, Salem S, Diagnostic Imaging Committee, Hudon L, Basso M, Bos H, Delisle MF, Farine D, Grabowska K, Menticoglou S, Mundle W
PubMed: 19772710
08/2009

Vaginal delivery of breech presentation.
Kotaska A, Menticoglou S, Gagnon R, Farine D, Basso M, Bos H, Delisle MF, Grabowska K, Hudon L, Mundle W, Murphy-Kaulbeck L, Ouellet A, Pressey T, Roggensack A, Maternal Fetal Medicine Committee, Society of Obstetricians and Gynaecologists of Canada
PubMed: 19646324
06/2009

Management of meconium at birth.
Roggensack A, Jefferies AL, Farine D, Basso M, Basso M, Delisle MF, Hudon L, Mundle WR, Murphy-Kaulbeck LC, Ouellet A, Pressey T
PubMed: 19497156
04/2009

Multiple courses of antenatal corticosteroids for preterm birth (MACS): a randomised controlled trial.
Murphy KE, Hannah ME, Willan AR, Hewson SA, Ohlsson A, Kelly EN, Matthews SG, Saigal S, Asztalos E, Ross S, Delisle MF, Amankwah K, Guselle P, Gafni A, Lee SK, Armson BA, MACS Collaborative Group
DOI: 10.1016/s0140-6736(08)61929-7
PubMed: 19101390
12/2008

The use of progesterone for prevention of preterm birth.
Farine D, Mundle WR, Dodd J, Basso M, Delisle MF, Farine D, Grabowska K, Hudon L, Menticoglou SM, Murphy-Kaulbeck LC, Ouellet A, Pressey T, Roggensack A, Gagnon R, Maternal Fetal Medicine Committee of the Society of Obstetricians and Gynaecologists of Canada
PubMed: 18198071
01/2008

Teratogenicity associated with pre-existing and gestational diabetes.
Allen VM, Armson BA, Wilson RD, Allen VM, Blight C, Gagnon A, Johnson JA, Langlois S, Summers A, Wyatt P, Farine D, Armson BA, Crane J, Delisle MF, Keenan-Lindsay L, Morin V, Schneider CE, Van Aerde J, Society of Obstetricians and Gynecologists of Canada
PubMed: 17977497
11/2007

Amniocentesis for twin pregnancies: is alpha-fetoprotein useful in confirming that the two sacs were sampled?
Delisle MF, Brosseuk L, Wilson RD
DOI: 10.1159/000098722
PubMed: 17228163
2007

Stillbirth and bereavement: guidelines for stillbirth investigation.
Maternal-Fetal Medicine Committee, Clinical Practice Obstetrics Committee, Leduc L, Farine D, Armson BA, Brunner M, Crane J, Delisle MF, Gagnon R, Keenan-Lindsay L, Morin V, Mundle RW, Scheider C, Van Aerde J
PubMed: 16874926
06/2006

The evaluation of the fetal fibronectin test for prediction of preterm delivery in symptomatic patients.
Skoll A, St Louis P, Amiri N, Delisle MF, Lalji S
PubMed: 16650359
03/2006

The impact of prenatal diagnosis on neural tube defect (NTD) pregnancy versus birth incidence in British Columbia.
Van Allen MI, Boyle E, Thiessen P, McFadden D, Cochrane D, Chambers GK, Langlois S, Stathers P, Irwin B, Cairns E, MacLeod P, Delisle MF, Uh SH
DOI: 10.1007/bf03194615
PubMed: 16682757
2006

Vesicouterine fistula in pregnancy: a case report.
Kives S, Delisle MF, Mitchell GW
PubMed: 15248935
07/2004

Cephalic index is not a useful sonographic marker for trisomy 21 and trisomy 18.
Lim KI, Delisle MF, Austin SJ, Wilson RD
DOI: 10.1159/000080161
PubMed: 15539873
2004

The association between early membrane rupture, latency, clinical chorioamnionitis, neonatal infection, and adverse perinatal outcomes in twin pregnancies complicated by preterm prelabour rupture of membranes.
von Dadelszen P, Kives S, Delisle MF, Wilson RD, Joy R, Ainsworth L, Al Kharusi L, Oskamp M, Barrett JF, Ryan G, Farine D, Seaward PG
DOI: 10.1375/136905203322296575
PubMed: 14511428
08/2003

A randomized controlled trial comparing two protocols for the use of misoprostol in midtrimester pregnancy termination.
Bebbington MW, Kent N, Lim K, Gagnon A, Delisle MF, Tessier F, Wilson RD
DOI: 10.1067/mob.2002.127461
PubMed: 12388963
10/2002

Failure of methotrexate and internal iliac balloon catheterization to manage placenta percreta.
Butt K, Gagnon A, Delisle MF
DOI: 10.1016/s0029-7844(02)02020-3
PubMed: 12052585
06/2002

Obstetric implications of the factor V leiden mutation: a review.
Bloomenthal D, Delisle MF, Tessier F, Tsang P
DOI: 10.1055/s-2002-20172
PubMed: 11857095
01/2002

Central nervous system complications of von Hippel-Lindau disease and pregnancy; perinatal considerations: case report and literature review.
Delisle MF, Valimohamed F, Money D, Douglas MJ
DOI: 10.1002/1520-6661(200007/08)9:43.0.co;2-5
PubMed: 11048837
2000

Outcome of fetuses diagnosed with atrioventricular septal defect.
Delisle MF, Sandor GG, Tessier F, Farquharson DF
DOI: 10.1016/s0029-7844(99)00389-0
PubMed: 10546725
11/1999

First trimester prenatal diagnosis: amniocentesis.
Delisle MF, Wilson RD
DOI: 10.1016/s0146-0005(99)80007-x
PubMed: 10551794
10/1999

Research

Amniocentesis for twin pregnancy
We are reviewing our data to evaluate if the level of AFP in the fluid can help in proving that the two sacs were sampled.

Early External Cephalic Version II
This is a multicenter trial. It will assess whether doing the procedure at an earlier time will ultimately decrease the caesarean section rate for term breech presentations.

External Cephalic Version
I have completed a study assessing the use of regional anesthesia at the time of external cephalic version. We hoped that this could increase the success rate of the procedure.

Honours & Awards

Award of Excellence for Contribution in Education, Education Services, Children’s & Women’s Heath Centre of British Columbia - May 2003

National Faculty Award of Excellency in Resident Education, The Council of Resident Education In Obstetrics and Gynecology - June 2001

Research Group Members

Kerrie Glover