Overview

As part of an inter-disciplinary team of engineers, computer scientists, and health care providers, I am involved in a wide range of projects focusing on the development and application of new technology, primarily in the pediatric anesthesia and intensive care setting. My main goal is to extract clinically-useful information from vital signs and other clinical data, and to transform these data into information for better, more timely, and more efficient decision-making by clinicians.

Publications

Clinician-driven design of VitalPAD – an intelligent monitoring and communication device to improve patient safety in the Intensive Care Unit
IEEE Journal of Translational Engineering in Health and Medicine
Luisa Flohr and Shaylene Beaudry and K Taneille Johnson and Nicholas West and Catherine M Burns and J Mark Ansermino and Guy A Dumont and David Wensley and Peter Skippen and Matthias Gorges
DOI: 10.1109/jtehm.2018.2812162
2018

Feasibility of continuous sedation monitoring in critically ill intensive care unit patients using the NeuroSENSE WAVCNS index
Journal of Clinical Monitoring and Computing
Nicholas West and Paul B. McBeth and Sonia M. Brodie and Klaske van Heusden and Sarah Sunderland and Guy A. Dumont and Donald E. G. Griesdale and J. Mark Ansermino and Matthias Görges
DOI: 10.1007/s10877-018-0115-6
12/2018

Data Access and Usage Practices Across a Cohort of Researchers at a Large Tertiary Pediatric Hospital: Qualitative Survey Study
JMIR Medical Informatics
Hoi Ki Kiki Ho and Matthias Görges and Elodie Portales-Casamar
DOI: 10.2196/medinform.8724
05/2018

Mortality Risk Using a Pediatric Quick Sequential (Sepsis-Related) Organ Failure Assessment Varies With Vital Sign Thresholds
Pediatric Critical Care Medicine
Cheryl Peters and Srinivas Murthy and Rollin Brant and Niranjan Kissoon and Matthias Görges
DOI: 10.1097/pcc.0000000000001598
06/2018

Effect of preoperative warming on intraoperative hypothermia: a randomized-controlled trial
Canadian Journal of Anesthesia/Journal canadien d'anesthésie
Aaron Lau and Nasim Lowlaavar and Erin M. Cooke and Nicholas West and Alexandra German and Dan J. Morse and Matthias Görges and Richard N. Merchant
DOI: 10.1007/s12630-018-1161-8
09/2018

An Ethnographic Observational Study to Evaluate and Optimize the Use of Respiratory Acoustic Monitoring in Children Receiving Postoperative Opioid Infusions
Anesthesia & Analgesia
Matthias Görges and Nicholas C. West and Nancy A. Christopher and Jennifer L. Koch and Sonia M. Brodie and Nasim Lowlaavar and Gillian R. Lauder and J. Mark Ansermino
DOI: 10.1213/ane.0000000000001127
04/2016

Using machine-to-machine / “Internet of Things” communication to simplify medical device information exchange
2014 International Conference on the Internet of Things (IOT)
Matthias Gorges and Guy A Dumont and Christian L Petersen and J Mark Ansermino
DOI: 10.1109/iot.2014.7030114
10/2014

Sequential allocation trial design in anesthesia: an introduction to methods, modeling, and clinical applications
Pediatric Anesthesia
Matthias Görges and Guohai Zhou and Rollin Brant and J. Mark Ansermino
DOI: 10.1111/pan.13088
03/2017

ICU nurses' evaluations of integrated information displays on user satisfaction and perceived mental workload.
DOI: 10.3233/978-1-61499-101-4-383
PubMed: 22874217
01/2012

Improving alarm performance in the medical intensive care unit using delays and clinical context.
DOI: 10.1213/ane.0b013e31819bdfbb
PubMed: 19372334
05/2009

Integrating intraoperative physiology data into outcome analysis for the ACS Pediatric National Surgical Quality Improvement Program
Pediatric Anesthesia
Matthias Görges and Kourosh Afshar and Nicholas West and Shanshan Pi and Julie Bedford and Simon D. Whyte
DOI: 10.1111/pan.13531
11/2018

In-hospital usability and feasibility evaluation of Panda, an app for the management of pain in children at home
Pediatric Anesthesia
Terri Sun and Dustin Dunsmuir and Ian Miao and Gregor M. Devoy and Nicholas C. West and Matthias Görges and Gillian R. Lauder and J. Mark Ansermino
DOI: 10.1111/pan.13471
10/2018

External Validation of the “Quick” Pediatric Logistic Organ Dysfunction-2 Score Using a Large North American Cohort of Critically Ill Children With Suspected Infection
Pediatric Critical Care Medicine
Matthias Görges and Cheryl Peters and Srinivas Murthy and Shanshan Pi and Niranjan Kissoon
DOI: 10.1097/pcc.0000000000001729
09/2018

Clinician-Driven Design of –An Intelligent Monitoring and Communication Device to Improve Patient Safety in the Intensive Care Unit
IEEE Journal of Translational Engineering in Health and Medicine
Luisa Flohr, Shaylene Beaudry, K Taneille Johnson, Nicholas West, Catherine M Burns, J Mark Ansermino, Guy A Dumont, David Wensley, Peter Skippen, Matthias Gorges
DOI: 10.1109/JTEHM.2018.2812162
2018

Design and Evaluation of a Closed-Loop Anesthesia System With Robust Control and Safety System
Anesthesia & Analgesia
Nicholas West and Klaske van Heusden and Matthias Görges and Sonia Brodie and Aryannah Rollinson and Christian L. Petersen and Guy A. Dumont and J. Mark Ansermino and Richard N. Merchant
DOI: 10.1213/ane.0000000000002663
11/2017

Closed-Loop Control of Total Intravenous Anesthesia During Significant Intraoperative Blood Loss
A & A Case Reports
Sonia M. Brodie and Matthias Görges and J. Mark Ansermino and Guy A. Dumont and Richard N. Merchant
DOI: 10.1213/xaa.0000000000000576
07/2017

In Response
Anesthesia & Analgesia
Christian Leth Petersen and Matthias Görges and Roslyn Massey and Guy Albert Dumont and J. Mark Ansermino
DOI: 10.1213/ane.0000000000001957
05/2017

Using physiological monitoring data for performance feedback: an initiative using thermoregulation metrics
Canadian Journal of Anesthesia/Journal canadien d'anesthésie
Matthias Görges and Nicholas C. West and Simon D. Whyte
DOI: 10.1007/s12630-016-0762-3
03/2017

Developing an objective method for analyzing vital signs changes in neonates during general anesthesia
Pediatric Anesthesia
Matthias Görges and Nicholas C. West and Edda Karlsdóttir and J. Mark Ansermino and Myles Cassidy and Gillian R. Lauder
DOI: 10.1111/pan.12994
11/2016

Preoperative warming and undesired surgical and anesthesia outcomes in pediatric spinal surgery-a retrospective cohort study
Pediatric Anesthesia
Matthias Görges and Nicholas C. West and Wesley Cheung and Guohai Zhou and Firoz Miyanji and Simon D. Whyte
DOI: 10.1111/pan.12939
09/2016

A Procedural Electroencephalogram Simulator for Evaluation of Anesthesia Monitors
Anesthesia & Analgesia
Christian Leth Petersen and Matthias Görges and Roslyn Massey and Guy Albert Dumont and J. Mark Ansermino
DOI: 10.1213/ane.0000000000001506
07/2016

Changes in QTc associated with a rapid bolus dose of dexmedetomidine in patients receiving TIVA: a retrospective study
Pediatric Anesthesia
Matthias Görges and Simon D. Whyte and Shubhayan Sanatani and Joy Dawes and Carolyne J. Montgomery and J. Mark Ansermino
DOI: 10.1111/pan.12780
10/2015

Development of mHealth Applications for Pre-Eclampsia Triage
IEEE J. Biomed. Health Inform.
Dustin T. Dunsmuir and Beth A. Payne and Garth Cloete and Christian Leth Petersen and Matthias Gorges and Joanne Lim and Peter von Dadelszen and Guy A. Dumont and J. Mark Ansermino
DOI: 10.1109/jbhi.2014.2301156
11/2014

Dexmedetomidine and hydromorphone: A novel pain management strategy for the oncology ward setting during anti-GD2 immunotherapy for high-risk neuroblastoma in children.
DOI: 10.1002/pbc.25197
PubMed: 25263424
09/2014

No BP During NIBP
09/2014

Identifying a rapid bolus dose of dexmedetomidine (ED50) with acceptable hemodynamic outcomes in children.
DOI: 10.1111/pan.12468
PubMed: 25040186
07/2014

A Scheme-based Closed-Loop Anesthesia System
DOI: 10.1145/2635648.2635651
2014

Evaluation of the effect of information integration in displays for ICU nurses on situation awareness and task completion time: A prospective randomized controlled study.
DOI: 10.1016/j.ijmedinf.2012.10.002
PubMed: 23357614
08/2013

An Evaluation of an Expert System for Detecting Critical Events During Anesthesia in a Human Patient Simulator
Anesthesia & Analgesia
Matthias Görges and Pamela Winton and Valentyna Koval and Joanne Lim and Jonathan Stinson and Peter T. Choi and Stephan K. W. Schwarz and Guy A. Dumont and J. Mark Ansermino
DOI: 10.1213/ane.0b013e3182975b63
08/2013

Changes in cardiac index and blood pressure on positioning children prone for scoliosis surgery.
DOI: 10.1111/anae.12310
PubMed: 23710730
07/2013

A retrospective audit to examine the effectiveness of preoperative warming on hypothermia in spine deformity surgery patients.
DOI: 10.1111/pan.12204
PubMed: 23738627
06/2013

Mobile Patient Monitoring for the Pediatric Intensive Care Unit: Work Domain Analysis and Rapid Prototyping Results
DOI: 10.1109/SMC.2013.642
2013

Experience report: functional programming of mHealth applications
DOI: 10.1145/2500365.2500615
2013

Evaluation of an integrated intensive care unit monitoring display by critical care fellow physicians.
DOI: 10.1007/s10877-012-9370-0
PubMed: 22588528
12/2012

Intensive care unit nurses' information needs and recommendations for integrated displays to improve nurses' situation awareness.
DOI: 10.1136/amiajnl-2011-000678
PubMed: 22437074
07/2012

University of Queensland Vital Signs Dataset
Anesthesia & Analgesia
David Liu and Matthias Görges and Simon A. Jenkins
DOI: 10.1213/ane.0b013e318241f7c0
03/2012

A Far-View Intensive Care Unit Monitoring Display Enables Faster Triage
Dimensions of Critical Care Nursing
Matthias Görges and Kai Kück and Sven H. Koch and Jim Agutter and Dwayne R. Westenskow
DOI: 10.1097/dcc.0b013e31821b7f08
07/2011

Medical device alarms
Biomedizinische Technik/Biomedical Engineering
Matthias Borowski and Matthias Görges and Roland Fried and Olaf Such and Christian Wrede and Michael Imhoff
DOI: 10.1515/bmt.2011.005
01/2011

A tool predicting future mean arterial blood pressure values improves the titration of vasoactive drugs.
DOI: 10.1007/s10877-010-9238-0
PubMed: 20559863
06/2010

Evaluation of an Ambient Color-Coded Display to Communicate Changes in the Patient’s Condition to ICU Nurses and Improve the Therapeutic Environment
DOI: 10.1177/154193121005401944
2010

Evaluations of physiological monitoring displays: a systematic review.
DOI: 10.1007/s10877-007-9106-8
PubMed: 18064532
02/2008

Research

VitalPAD: an intelligent monitoring and communication device to optimize safety in the pediatric intensive care unit (PICU)
The goal is to develop a unified, portable and intelligent device that integrates information from multiple patient monitors, mechanical ventilators, infusion pumps and clinical information systems. It will allow PICU healthcare team members, on or off-site, to monitor critically ill patients continuously. The project involves two components: a) We will use feedback obtained in a participatory design process to guide the development of the VitalPAD, and b) We will use simulated ICU scenarios, to evaluate whether clinicians will prioritize the care of critically ill patients more rapidly and more accurately with the use of VitalPAD than without it.

Sepsis modeling and outcome prediction
Severe sepsis and septic shock are associated with a high burden of morbidity and mortality among critically ill children. Through improvements in supportive care, secular trends reveal a gradual decline in mortality. In collaboration with our critical care colleagues, our goal is to use a large North-American registry cohort to validate and compare the performance of existing risk score, identify new combinations of risk factors, and to develop novel outcome prediction tools.

Automated intravenous anesthesia delivery to improve outcomes
As a highly experienced, interdisciplinary team of engineers and clinician-scientists, we have developed a system that automatically adjusts drug dosing. It does so by comparing feedback on anesthesia depth, using processed electrical activity from the patient's brain to a clinician-selected target. By administering the right amount of anesthesia drugs to patients, it minimizes side effects of these drugs, and allows clinicians to focus on optimizing patient safety through complex, high-level decision making. We are currently evaluating the performance of this system during general anesthesia for both adults and children. Future work includes expanding this work towards other users, such as nurses, and settings, such as intensive care unit sedation.

Grants

2016-07, Project Grant, Canadian Institutes of Health Research

2016-04, Residents' Research Grant [PI: Terri Sun], Canadian Anesthesiologists' Society

2017-03, Evidence to Innovation Seed Grant, BC Children’s Hospital Research Institute (BCCHR)

2018-03, Evidence to Innovation Seed Grant, BC Children’s Hospital Research Institute (BCCHR)

2018-06, Designing for People (DFP) Project Origination Fund, University of British Columbia

Honours & Awards

2018-06, DFP Design Showcase Unicorn award. [KT Johnson presented the work], Designing for People – Human Computer Interaction @ UBC Initiative

2017-05, 2017 Abstract Scholarship award. [C Peters presented the work], American Thoracic Society

2018-05, 2nd place - Poster Presentations. [R Ridgeway presented the work], Anesthesiology Pharmacology & Therapeutics Research Day, University of British Columbia

2018-01, Best Clinical Application Award. [D Dunsmuir presented the work], Society for Technology in Anesthesia

2017-09, Research Day 2017 Award of Excellence - Outstanding Research Poster Presentation [KT Johnson presented the work], Evidence to Innovation Theme, BC Children's Hospital Research Institute

2018-01, Best of Show Award. [K Allen and I co-presented the work], Society for Technology in Anesthesia

Research Group Members

Luisa Flohr, Pediatrics Resident
Kristina Gagalova, Work Learn Student
Niema Ghanad Poor, Co-op student
Rosa Hillgruber, Co-op student
Celine Hügel, Co-op student
Taneille Johnson, Pediatric Resident
Cynthia Liu, Postdoctoral fellow
Georg Seidel, Co-op student
Nicholas West, Clinical Research Coordinator