- Overview
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My research program aims at investigating how early-life stress (e.g. pain, inflammation, clinical treatments) affects the developing brain of very preterm infants, conducting pre-clinical and clinical research. I use an animal model that closely captures critical aspects of what preterm infants are like and what they may experience in the NICU. The use of preclinical models allows mechanistic studies on how exposure to early-life adversity alters the normal trajectory of brain development. This research, in turn, better informs clinical studies in preterm infants and the development of novel treatments to mitigate adverse effects from these exposures.
This work is motivated by my clinical nursing background as a paediatric clinical nurse specialist in acute pain, and builds upon my doctoral training in infant brain reactivity to pain (McGill University/Harvard University/Boston Children’s Hospital) and postdoctoral fellowship in pediatrics/neuroscience at UBC (2012-16), as well as my work as a research scientist at Columbia University in the division of Developmental Neuroscience (2017-18).
- Publications
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Association Between Follow-Up Visit Timing After A Concussion and Subsequent Care Seeking in Children and Youth: A Population-Based Study in British Columbia
Journal of Head Trauma Rehabilitation
Ramsay, S. and Dahinten, V.S. and Ranger, M. and Babul, S. and Saewyc, E.
DOI: 10.1097/HTR.0000000000001001
2025Follow-up visits after pediatric concussion and the factors associated with early follow-up: a population-based study in British Columbia
Brain Injury
Ramsay, S. and Dahinten, V.S. and Ranger, M. and Babul, S. and Saewyc, E.
DOI: 10.1080/02699052.2024.2395382
2025Sweet relief or lasting impacts? Review of neonatal pain and sucrose in developing rodents
Pain Reports
Hoq, F.S. and Newby, C. and Tremblay, S. and Ranger, M.
DOI: 10.1097/PR9.0000000000001345
2025Neonatal Sucrose and Internalizing Behaviors at 18 Months in Children Born Very Preterm
JAMA Network Open
McLean, M.A. and Ranger, M. and Bone, J.N. and Selvanathan, T. and Au-Young, S.H. and Chau, C.M.Y. and Chau, V. and Ly, L. and Kelly, E. and Synnes, A. and Miller, S.P. and Grunau, R.E.
DOI: 10.1001/jamanetworkopen.2025.4477
2025Adolescents’ perspectives on non-pharmacological pain interventions for sickle cell crisis management: A population-based survey
Plos One
Ibitoye, B.M. and Garrett, B. and Ranger, M. and Stinson, J.N.
DOI: 10.1371/journal.pone.0330127
2025You only work with what you know: Healthcare providers’ experiences using non-pharmacological interventions in managing sickle cell crisis pain in adolescents
Journal of Pain
Ibitoye, B.M. and Garrett, B. and Ranger, M. and Stinson, J.N.
DOI: 10.1016/j.jpain.2025.105551
2025Outcomes Associated With Care Models for Neonates With Complex Medical Needs: A Scoping Review to Support Program Evaluation
Advances in Neonatal Care
Loewen, N. and Ranger, M. and Kieran, E.
DOI: 10.1097/ANC.0000000000001225
2025Creating a calmer NICU: Parental and nursing perspectives of a therapeutic device
Journal of Neonatal Nursing
Ranger, M. and Marriott, N. and Seabrook, L. and Garga, D. and Holsti, L.
DOI: 10.1016/j.jnn.2025.101741
2025Conducting Patient-Oriented Research in Low-Income and Middle-Income Countries: A Scoping Review
Patient
Ibitoye, B.M. and Garrett, B. and Ranger, M. and Stinson, J.
DOI: 10.1007/s40271-022-00592-w
2023Non-pharmacological pain interventions for sickle cell crisis in pediatrics: A scoping review
Journal of Pediatric Nursing
Ibitoye, B.M. and Garrett, B. and Ranger, M. and Stinson, J.
DOI: 10.1016/j.pedn.2023.03.002
2023Follow-up visits after a concussion in the pediatric population: An integrative review
Neurorehabilitation
Ramsay, S. and Dahinten, V.S. and Ranger, M. and Babul, S.
DOI: 10.3233/NRE-220216
2023Experiences of Mothers of Preterm Infants in the Neonatal Intensive Care Unit during the COVID-19 Pandemic
Advances in Neonatal Care
Richter, L.L. and Ku, C. and Mak, M.Y.Y. and Holsti, L. and Kieran, E. and Alonso-Prieto, E. and Ranger, M.
DOI: 10.1097/ANC.0000000000001071
2023Participants' experience in using a point of Care Rapid Antigen Test (RAT) for SARS-CoV-2
Annals of Family Medicine
Ndateva, I. and Schwandt, M. and Saewyc, E. and Sin, D. and Tobias, E. and Wong, S. and Haase, K. and Ranger, M.
DOI: 10.1370/afm.20.s1.3104
2022Engaging nursing students in a COVID-19 Point-of-Care rapid screening clinic
Nursing Open
Dhari, R. and Haase, K. and Ranger, M. and Tan, E. and Affleck, F. and Bailey, E. and Wong, S.T.
DOI: 10.1002/nop2.1272
2022ATTENTIV: Instrumented Peripheral Catheter for the Detection of Catheter Dislodgement in IV Infiltration
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society EMBS
Bo, J.Y. and Ta, K. and Nishida, R. and Yeh, G. and Tsang, V.W.L. and Bolton, M. and Ranger, M. and Walus, K.
DOI: 10.1109/EMBC48229.2022.9871840
2022The international Perinatal Outcomes in the Pandemic (iPOP) study: protocol [version 1; peer review: 2 approved]
Sarah J. Stock and Helga Zoega and Meredith Brockway and Rachel H. Mulholland and Jessica E. Miller and Jasper V. Been and Rachael Wood and Ishaya I. Abok and Belal Alshaikh and Adejumoke I. Ayede and Fabiana Bacchini and Zulfiqar A. Bhutta and Bronwyn K. Brew and Jeffrey Brook and Clara Calvert and Marsha Campbell-Yeo and Deborah Chan and James Chirombo and Kristin L. Connor and Mandy Daly and Kristjana Einarsdóttir and Ilaria Fantasia and Meredith Franklin and Abigail Fraser and Siri Eldevik Håberg and Lisa Hui and Luis Huicho and Maria C. Magnus and Andrew D. Morris and Livia Nagy-Bonnard and Natasha Nassar and Sylvester Dodzi Nyadanu and Dedeke Iyabode Olabisi and Kirsten R. Palmer and Lars Henning Pedersen and Gavin Pereira and Amy Racine-Poon and Manon Ranger and Tonia Rihs and Christoph Saner and Aziz Sheikh and Emma M. Swift and Lloyd Tooke and Marcelo L. Urquia and Clare Whitehead and Christopher Yilgwan and Natalie Rodriguez and David Burgner and Meghan B. Azad and iPOP Study
DOI: 10.12688/wellcomeopenres.16507.1
02/2021Cerebral hemodynamic response to a therapeutic bed for procedural pain management in preterm infants in the NICU: a randomized controlled trial
Pain Reports
Ranger, M. and Albert, A. and MacLean, K. and Holsti, L.
DOI: 10.1097/PR9.0000000000000890
2021Maternal separation affects fronto-cortical activity in rat pups during dam-pup interactions and behavioral transitions
Biorxiv
Ranger, M. and Behring, T.B. and Kaidbey, J.H. and Anwar, M. and Lipshutz, A.B. and Mollicone, I. and Hassan, G. and Fasano, K. and Hinz, N.K. and Ludwig, R.J. and Myers, M.M. and Welch, M.G. and Dumitriu, D.
DOI: 10.1101/2021.05.19.444831
2021Sex-specific effects of neonatal oral sucrose treatment on growth and liver choline and glucocorticoid metabolism in adulthood
American Journal of Physiology Regulatory Integrative and Comparative Physiology
Ram{\'i}rez-Contreras, C.Y. and Mehran, A.E. and Salehzadeh, M. and Mussai, E.-X. and Miller, J.W. and Smith, A. and Ranger, M. and Holsti, L. and Soma, K.K. and Devlin, A.M.
DOI: 10.1152/ajpregu.00091.2021
2021Feasibility and utility of rapid antigen testing for COVID-19 in a university residence: A cross sectional study
Medrxiv
Wong, S.T. and Romney, M.G. and Haase, K. and Matic, N. and Ranger, M. and Dhari, R. and Affleck, F. and Tan, E. and Ndateba, I. and Tobias, E. and Saewyc, E. and Schwandt, M. and Sin, D.D.
DOI: 10.1101/2021.05.24.21257732
2021Designing and Evaluating Calmer, a Device for Simulating Maternal Skin-to-Skin Holding for Premature Infants
Conference on Human Factors in Computing Systems Proceedings
Hauser, S. and Suto, M.J. and Holsti, L. and Ranger, M. and MacLean, K.E.
DOI: 10.1145/3313831.3376539
2020Early Life Maternal Separation and Maternal Behaviour Modulate Acoustic Characteristics of Rat Pup Ultrasonic Vocalizations
Scientific Reports
Kaidbey, J.H. and Ranger, M. and Myers, M.M. and Anwar, M. and Ludwig, R.J. and Schulz, A.M. and Barone, J.L. and Kolacz, J. and Welch, M.G.
DOI: 10.1038/s41598-019-54800-z
2019Hippocampus, amygdala, and thalamus volumes in very preterm children at 8 years: Neonatal pain and genetic variation
Frontiers in Behavioral Neuroscience
Chau, C.M.Y. and Ranger, M. and Bichin, M. and Park, M.T.M. and Amaral, R.S.C. and Chakravarty, M. and Poskitt, K. and Synnes, A.R. and Miller, S.P. and Grunau, R.E.
DOI: 10.3389/fnbeh.2019.00051
2019Adverse behavioral changes in adult mice following neonatal repeated exposure to pain and sucrose
Frontiers in Psychology
Ranger, M. and Tremblay, S. and Chau, C.M.Y. and Holsti, L. and Grunau, R.E. and Goldowitz, D.
DOI: 10.3389/fpsyg.2018.02394
2019Is near infrared spectroscopy valid for the detection of procedural pain in postoperative cardiac surgery intensive care unit adults?
Journal of Near Infrared Spectroscopy
Gélinas, C. and Boitor, M. and Ranger, M. and Johnston, C.C. and De Marchie, M. and Cervero, F. and Choinière, M.
DOI: 10.1177/0967033517730369
2017Developmental Aspects of Pain
Fetal and Neonatal Physiology 2 Volume Set
Ranger, M. and Beggs, S. and Grunau, R.E.
DOI: 10.1016/B978-0-323-35214-7.00137-2
2017Repeated exposure to sucrose for procedural pain in mouse pups leads to long-term widespread brain alterations
Pain
Tremblay, S. and Ranger, M. and Chau, C.M.Y. and Ellegood, J. and Lerch, J.P. and Holsti, L. and Goldowitz, D. and Grunau, R.E.
DOI: 10.1097/j.pain.0000000000000961
2017Neonatal Invasive Procedures Predict Pain Intensity at School Age in Children Born Very Preterm
Clinical Journal of Pain
Valeri, B.O. and Ranger, M. and Chau, C.M.Y. and Cepeda, I.L. and Synnes, A. and Linhares, M.B.M. and Grunau, R.E.
DOI: 10.1097/AJP.0000000000000353
2016How do babies feel pain?
eLife
Ranger, M. and Grunau, R.E.
DOI: 10.7554/eLife.07552
2015Neonatal Pain and Infection Relate to Smaller Cerebellum in Very Preterm Children at School Age
Journal of Pediatrics
Ranger, M. and Zwicker, J.G. and Chau, C.M.Y. and Park, M.T.M. and Chakravarthy, M.M. and Poskitt, K. and Miller, S.P. and Bjornson, B.H. and Tam, E.W.Y. and Chau, V. and Synnes, A.R. and Grunau, R.E.
DOI: 10.1016/j.jpeds.2015.04.055
2015Early repetitive pain in preterm infants in relation to the developing brain
Pain management
Ranger, M. and Grunau, R.E.
DOI: 10.2217/pmt.13.61
2014Neonatal pain and comt Val158Met genotype in relation to serotonin transporter (SLC6A4) promoter methylation in very preterm children at school age
Frontiers in Behavioral Neuroscience
Chau, C.M.Y. and Ranger, M. and Sulistyoningrum, D. and Devlin, A.M. and Obertander, T.F. and Grunau, R.E.
DOI: 10.3389/fnbeh.2014.00409
2014Innovating in Pain Assessment of the Critically Ill: Exploring Cerebral Near-Infrared Spectroscopy as a Bedside Approach
Pain Management Nursing
Ranger, M. and Gélinas, C.
DOI: 10.1016/j.pmn.2012.03.005
2014Internalizing behaviours in school-age children born very preterm are predicted by neonatal pain and morphine exposure
European Journal of Pain (United Kingdom)
Ranger, M. and Synnes, A.R. and Vinall, J. and Grunau, R.E.
DOI: 10.1002/j.1532-2149.2013.00431.x
2014Neonatal Pain
Treatment of Chronic Pain by Integrative Approaches the American Academy of Pain Medicine Textbook on Patient Management
Johnston, C. and Campbell-Yeo, M. and Fernandes, A. and Ranger, M.
DOI: 10.1007/978-1-4939-1821-8_22
2014A multidimensional approach to pain assessment in critically ill infants during a painful procedure
Clinical Journal of Pain
Ranger, M. and Celeste Johnston, C. and Rennick, J.E. and Limperopoulos, C. and Heldt, T. and Du Plessis, A.J.
DOI: 10.1097/AJP.0b013e31826dfb13
2013Neonatal Pain-Related Stress Predicts Cortical Thickness at Age 7 Years in Children Born Very Preterm
PLoS ONE
Ranger, M. and Chau, C.M.Y. and Garg, A. and Woodward, T.S. and Beg, M.F. and Bjornson, B. and Poskitt, K. and Fitzpatrick, K. and Synnes, A.R. and Miller, S.P. and Grunau, R.E.
DOI: 10.1371/journal.pone.0076702
2013Maternal Touch and Talk for Invasive Procedures in Infants and Toddlers in the Pediatric Intensive Care Unit
Journal of Pediatric Nursing
Johnston, C.C. and Rennick, J.E. and Filion, F. and Campbell-Yeo, M. and Goulet, C. and Bell, L. and Tucci, M. and Ranger, M.
DOI: 10.1016/j.pedn.2010.12.016
2012Cerebral near-infrared spectroscopy as a measure of nociceptive evoked activity in critically ill infants
Pain Research and Management
Ranger, M. and Johnston, C.C. and Limperopoulos, C. and Rennick, J.E. and Du Plessis, A.J.
2011Incidence of self-limiting back pain in children following caudal blockade: An exploratory study
Paediatric Anaesthesia
Valois, T. and Otis, A. and Ranger, M. and Muir, J.G.
DOI: 10.1111/j.1460-9592.2010.03365.x
2010Toward a new approach for the detection of pain in adult patients undergoing cardiac surgery: Near-infrared spectroscopy—A pilot study
Heart and Lung: Journal of Acute and Critical Care
Gélinas, C. and Choinière, M. and Ranger, M. and Denault, A. and Deschamps, A. and Johnston, C.
DOI: 10.1016/j.hrtlng.2009.10.018
2010Interventions used in Emergency Departments (ED) for pain management of simple fractures in children
Cochrane Database of Systematic Reviews
Le May, S. and Fortin, C. and Johnston, C. and Choiniere, M. and Gouin, S. and Paquette, G. and Ranger, M.
DOI: 10.1002/14651858.CD007538
2009Developing synergy to enhance the impact of nursing intervention research on patient health
Canadian Journal of Nursing Research
Johnston, C. and Cossette, S. and Archer, J. and Ranger, M. and Nahas-Chebli, G.
2009Controlling bias in complex nursing intervention studies: A checklist
Canadian Journal of Nursing Research
Campbell-Yeo, M. and Ranger, M. and Johnston, C. and Fergusson, D.
2009An acute pain service improves postoperative pain management for children undergoing selective dorsal rhizotomy
Paediatric Anaesthesia
Frigon, C. and Loetwiriyakul, W. and Ranger, M. and Otis, A.
DOI: 10.1111/j.1460-9592.2009.03184.x
2009Temperament and Pain Response: A Review of the Literature
Pain Management Nursing
Ranger, M. and Campbell-Yeo, M.
DOI: 10.1016/j.pmn.2007.09.005
2008Theoretical, Psychometric, and Pragmatic Issues in Pain Measurement
Pain Management Nursing
Gélinas, C. and Loiselle, C.G. and LeMay, S. and Ranger, M. and Bouchard, E. and McCormack, D.
DOI: 10.1016/j.pmn.2007.12.001
2008Current Controversies Regarding Pain Assessment in Neonates
Seminars in Perinatology
Ranger, M. and Johnston, C.C. and Anand, K.J.S.
DOI: 10.1053/j.semperi.2007.07.003
2007Continuous axillary block for paediatric trauma patients who failed with PCA therapy
Acute Pain
Ranger, M. and Desparmet, J. and Goujard, E.
DOI: 10.1016/j.acpain.2006.09.001
2006Horner's syndrome following thoracic epidural analgesia in children: A report of two cases
Acute Pain
Valois, T. and Ranger, M. and Raghavendran, S.
DOI: 10.1016/j.acpain.2006.05.001
2006 - Research
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The role of neuroinflammation in early life pain/sucrose-induced neurodevelopment impairments
Improving access to pediatric symptom management: Engaging and educating health care practitioners to improve lives for children with serious illness in Nepal
Creating a Calmer NICU: Pilot Testing a Robot for Optimizing Brain Development in Preterm Infants in the NICU
Brain-to-brain synchrony in mother-child and father-child dyads: a novel biomarker of brain development
GrantsHealthy Starts Catalyst grant (2021-2023)
Sheena Davidson Nursing Research Fund (2020-2022)
Research Group MembersSarah Coutts, Clinical trainee
Gael Hernandez Palmer, Capstone Student, Undergraduate Student, Worklearn Research Assistant
Bukola Ibitoye, Research Associate
Rujun Kang, Research Assistant/Lab Technician Level 4
Natalie Pinto, Trainee volunteer
Emily Schraeder, Master Student
Megan Stewart, Research Assistant
Shawn Thai, Student volunteer
Emily VanBergen, Student Volunteer
Reducing the impact of pain in the youngest children: Q&A with Dr. Manon Ranger
Dr. Manon Ranger is a new investigator at BC Children's Hospital and UBC studying new ways to reduce the impact of pain and early life stress on preterm babies.
