Matthew Wiens

BSc, PharmD, PhD

Investigator, BC Children's Hospital

I am a public health researcher with an interest in improving long term outcomes for children with sepsis. In countries like Uganda, as many children die following hospital discharge as die during the initial hospitalization. Most of these deaths occur at home, and are largely preventable. The last point of contact with the health system for most children who go on to die is during the discharge period. However, the discharge process is often not considered a critical period of the illness, and is not conducted in a way that allows for appropriate monitoring for recurrent illness. Over the past decade my research team has developed tools to allow health workers to rapidly predict which children at highest risk of dying after discharge, and also have developed our “Smart Discharges” approach to care during and after discharge. Our approach focuses on both patient counselling and education, as well a risk guided referral for appropriate post-discharge care for those most likely to benefit from this. This individualized approach ensures both affordability to the health system as well as attention to the most vulnerable.

Academic Affiliations

  • Assistant Professor, , Department of Anesthesiology, Pharmacology & Therapeutics, Faculty of Medicine, University of British Columbia
  • Research Theme: Healthy Starts
  • Research Group(s): Global Health and Innovations

Contact Information

Location

Center for International Child Health, 305-4088 Cambie Street, Vancouver, British Columbia, Canada, V5Z 2X8

Assessing the validity of post-discharge readmission and mortality as a composite outcome among newborns in Uganda

PLOS One

Abhroneel Ghosh and Chris A Rees and Vuong Nguyen and J. Mark Ansermino and Yashodani Pillay and Angella Namala and Joseph Ngonzi and Nathan Kenya-Mugisha and Niranjan Kissoon and Matthew O. Wiens

DOI: 10.1371/journal.pone.0332787

02 / 2026

Using Hourly Aggregated Respiratory Rate and Expiratory Time with Machine Learning to Identify Remote COPD Exacerbations

R. Smunyahirun and T. Filhol and T. Trakoolwilaiwan and R. Al-Ani and M. Lynn and L. Liang and G. Balasundaram and J. Lombay and G. Singh and M. O. Wiens and P. Moschovis and M. Olivo

DOI: 10.1101/2025.10.24.25338693

10 / 2025

Smart Discharges improves post-discharge mortality among children with suspected sepsis in Uganda: A prospective before-after study

Matthew O Wiens and Cherri Zhang and Vuong Nguyen and Jeffrey N Bone and Elias Kumbakumba and Stephen Businge and Abner Tagoola and Emmanuel Tenywa and Sheila Oyella Sherine and Emmanuel Byaruhanga and Edward Ssemwanga and Jesca Nsungwa and Charles Olaro and J Mark Ansermino and Niranjan Kissoon and Joel Singer and Charles P Larson and Pascal M Lavoie and Dustin Dunsmuir and Peter P Moschovis and Stefanie Novakowski and Jessica Trawin and Clare Komugisha and Bernard T Opar and Mellon Tayebwa and Douglas Mwesigwa and Nicholas West and Nathan Kenya Mugisha and Jerome Kabakyenga

DOI: 10.1101/2025.08.25.25334336

08 / 2025

Exposure to pollutants for household cooking and lighting and pediatric post-discharge mortality following a severe infection in Uganda

PLOS One

Gurvir S. Dhutt and Srijan Lal Shrestha and Cherri Zhang and Elias Kumbakumba and Abner Tagoola and Peter Moschovis and Stephen Businge and Niranjan Kissoon and Nathan Kenya Mugisha and Jerome Kabakyenga and Matthew O. Wiens

DOI: 10.1371/journal.pone.0326105

07 / 2025

The 2024 Phoenix Sepsis Score Criteria: Part 4, What About Using World-Oriented Criteria?

Pediatric Critical Care Medicine

Matthew O. Wiens and Enitan D. Carrol and Mohammod Jobayer Chisti and Daniela Carla de Souza and Rakesh Lodha and Suchitra Ranjit and Niranjan Kissoon

DOI: 10.1097/PCC.0000000000003663

02 / 2025

Repeatability of RRate measurements in children during triage in two Ugandan hospitals

PLOS Global Public Health

Ahmad Asdo and Alishah Mawji and Isaac Omara and Ivan Aine Aye Ishebukara and Clare Komugisha and Stefanie K. Novakowski and Yashodani Pillay and Matthew O. Wiens and Samuel Akech and Florence Oyella and Abner Tagoola and Niranjan Kissoon and John Mark Ansermino and Dustin Dunsmuir

DOI: 10.1371/journal.pgph.0003097

01 / 2025

Caregivers and nurses perceptions of the Smart Discharges Program for children with sepsis in Uganda: A qualitative study

PLOS ONE

Justine Behan and Olive Kabajaasi and Brooklyn Derksen and George Sendegye and Brenda Kugumikiriza and Clare Komugisha and Radhika Sundararajan and Shevin T. Jacob and Nathan Kenya-Mugisha and Matthew O. Wiens

DOI: 10.1371/journal.pone.0307089

10 / 2024

Geographical validation of the Smart Triage Model by age group

PLOS Digital Health

Cherri Zhang and Matthew O. Wiens and Dustin Dunsmuir and Yashodani Pillay and Charly Huxford and David Kimutai and Emmanuel Tenywa and Mary Ouma and Joyce Kigo and Stephen Kamau and Mary Chege and Nathan Kenya-Mugisha and Savio Mwaka and Guy A. Dumont and Niranjan Kissoon and Samuel Akech and J Mark Ansermino

DOI: 10.1371/journal.pdig.0000311

07 / 2024

Prediction models for post-discharge mortality among under-five children with suspected sepsis in Uganda: A multicohort analysis

PLOS Global Public Health

Matthew O. Wiens and Vuong Nguyen and Jeffrey N. Bone and Elias Kumbakumba and Stephen Businge and Abner Tagoola and Sheila Oyella Sherine and Emmanuel Byaruhanga and Edward Ssemwanga and Celestine Barigye and Jesca Nsungwa and Charles Olaro and J. Mark Ansermino and Niranjan Kissoon and Joel Singer and Charles P. Larson and Pascal M. Lavoie and Dustin Dunsmuir and Peter P. Moschovis and Stefanie Novakowski and Clare Komugisha and Mellon Tayebwa and Douglas Mwesigwa and Martina Knappett and Nicholas West and Nathan Kenya Mugisha and Jerome Kabakyenga

DOI: 10.1371/journal.pgph.0003050

04 / 2024

World Health Organization Danger Signs to predict bacterial sepsis in young infants: A pragmatic cohort study

PLOS Global Public Health

Omolabake Akinseye and Constantin R. Popescu and Msandeni Chiume-Kayuni and Michael A. Irvine and Norman Lufesi and Tisungane Mvalo and Niranjan Kissoon and Matthew O. Wiens and Pascal M. Lavoie

DOI: 10.1371/journal.pgph.0001990

11 / 2023

Caregivers and nurses perceptions of the Smart Discharges Program for children with sepsis in Uganda: A descriptive qualitative study

Justine Behan and Olive Kabajaasi and Brooklyn Derksen and George Sendegye and Brenda Kugumikiriza and Clare Komugisha and Radhika Sundararajan and Shevin T. Jacob and Nathan Kenya-Mugisha and Matthew O. Wiens

DOI: 10.1101/2023.07.18.23292842

07 / 2023

World Health Organization Danger Signs to predict bacterial sepsis in newborns: A pragmatic prospective cohort study

Omolabake Akinseye and Constantin R. Popescu and Msandeni Chiume-Kayuni and Michael A. Irvine and Norman Lufesi and Tisungane Mvalo and Niranjan Kissoon and Matthew O. Wiens and Pascal M. Lavoie

DOI: 10.1101/2023.05.09.23289739

05 / 2023

Repeatability of Pulse Oximetry Measurements in Children During Triage in Two Ugandan Hospitals

Ahmad Asdo and Alishah Mawji and Collins Agaba and Clare Komugisha and Stefanie K Novakowski and Yashodani Pillay and Stephen Kaumu and Matthew O Wiens and Samuel Akech and Abner Tagoola and Niranjan Kissoon and J Mark Ansermino and Dustin Dunsmuir

DOI: 10.1101/2022.12.21.22283800

12 / 2022

A proposed de-identification framework for a cohort of children presenting at a health facility in Uganda

PLOS Digital Health

Alishah Mawji and Holly Longstaff and Jessica Trawin and Dustin Dunsmuir and Clare Komugisha and Stefanie K. Novakowski and Matthew O. Wiens and Samuel Akech and Abner Tagoola and Niranjan Kissoon and J. Mark Ansermino

DOI: 10.1371/journal.pdig.0000027

08 / 2022

Use, cost-effectiveness, and end user perspectives of a home solar lighting intervention in rural Uganda: a mixed methods, randomized controlled trial

Environmental Research Letters

Radhika Sundararajan and Helen DCouto and Joseph Mugerwa and Mellon Tayebwa and Nicholas L Lam and Eli S Wallach and Matthew O Wiens and Matthew Ponticiello and Debbi Stanistreet and Alexander C Tsai and Jose Vallarino and Joseph G Allen and Daniel Muyanja and Mark G Shrime and Edwin Nuwagira and Peggy S Lai

DOI: 10.1088/1748-9326/ac3f05

01 / 2022

Derivation and internal validation of a data-driven prediction model to guide frontline health workers in triaging children under-five in Nairobi, Kenya

Wellcome Open Research

Alishah Mawji and Samuel Akech and Paul Mwaniki and Dustin Dunsmuir and Jeffrey Bone and Matthew O. Wiens and Matthias Grges and David Kimutai and Niranjan Kissoon and Mike English and Mark J. Ansermino

DOI: 10.12688/wellcomeopenres.15387.3

04 / 2021

Impact of a Solar Lighting Intervention on Social Determinants of Health in Rural Uganda: A Mixed Methods, Randomized Controlled Trial

SSRN

Sundararajan, R. and D?Couto, H. and Mugerwa, J. and Tayebwa, M. and Lam, N. and Wallach, E. and Wiens, M. and Stanistreet, D. and Tsai, A.C. and Vallarino, J. and Allen, J.G. and Muyanja, D. and Nuwagira, E. and Lai, P.S.

DOI: 10.2139/ssrn.3756809

Common data elements for predictors of pediatric sepsis: A framework to standardize data collection

PLoS ONE

Mawji, A. and Li, E. and Chandna, A. and Kortz, T. and Akech, S. and Wiens, M.O. and Kissoon, N. and Ansermino, M.

DOI: 10.1371/journal.pone.0253051

Anticipating the future: Prognostic tools as a complementary strategy to improve care for patients with febrile illnesses in resource-limited settings

BMJ Global Health

Chandna, A. and Osborn, J. and Bassat, Q. and Bell, D. and Burza, S. and D'Acremont, V. and Leticia Fernandez-Carballo, B. and Kain, K.C. and Mayxay, M. and Wiens, M. and Dittrich, S.

DOI: 10.1136/bmjgh-2021-006057

Challenges in pediatric post-sepsis care in resource limited settings: A narrative review

Translational Pediatrics

Wiens, M.O. and Kissoon, N. and Holsti, L.

DOI: 10.21037/tp-20-390

Out of pocket costs and time/productivity losses for pediatric sepsis in Uganda: a mixed-methods study

BMC Health Services Research

Krepiakevich, A. and Khowaja, A.R. and Kabajaasi, O. and Nemetchek, B. and Ansermino, J.M. and Kissoon, N. and Mugisha, N.K. and Tayebwa, M. and Kabakyenga, J. and Wiens, M.O.

DOI: 10.1186/s12913-021-07272-9

Evaluation of a digital triage platform in Uganda: A quality improvement initiative to reduce the time to antibiotic administration

PLoS ONE

Lee, V. and Dunsmuir, D. and Businge, S. and Tumusiime, R. and Karugaba, J. and Wiens, M.O. and Grges, M. and Kissoon, N. and Orach, S. and Kasyaba, R. and Ansermino, J.M.

DOI: 10.1371/journal.pone.0240092

Whole blood genome-wide transcriptome profiling and metagenomics next-generation sequencing in young infants with suspected sepsis in a low-and middle-income country: A study protocol

Gates Open Research

Lavoie, P.M. and Popescu, C.R. and Tembo, B. and Chifisi, R. and Cavanagh, M.M.M. and Lee, A.-Y. and Chiluzi, B. and Ciccone, E.J. and Tegha, G. and Alonso-Prieto, E. and Claydon, J. and Dunsmuir, D. and Irvine, M. and Dumont, G. and Ansermino, J.M. and Wiens, M.O. and Juliano, J.J. and Kissoon, N. and Mvalo, T. and Lufesi, N. and Chiume-Kayuni, M.

DOI: 10.12688/gatesopenres.13172.2

Smart triage: Triage and management of sepsis in children using the point-of-care Pediatric Rapid Sepsis Trigger (PRST) tool

BMC Health Services Research

Mawji, A. and Li, E. and Komugisha, C. and Akech, S. and Dunsmuir, D. and Wiens, M.O. and Kissoon, N. and Kenya-Mugisha, N. and Tagoola, A. and Kimutai, D. and Bone, J.N. and Dumont, G. and Ansermino, J.M.

DOI: 10.1186/s12913-020-05344-w

Determining predictors of sepsis at triage among children under 5 years of age in resource-limited settings: A modified Delphi process

PLoS ONE

Fung, J.S.T. and Akech, S. and Kissoon, N. and Wiens, M.O. and English, M. and Mark Ansermino, J.

DOI: 10.1371/journal.pone.0211274

Very severe anemia and one year mortality outcome after hospitalization in Tanzanian children: A prospective cohort study

bioRxiv

Chami, N. and Hau, D.K. and Masoza, T.S. and Smart, L.R. and Kayange, N.M. and Hokororo, A. and Ambrose, E.E. and Moschovis, P.P. and Wiens, M.O. and Peck, R.N.

DOI: 10.1101/581462

Re: "Investment Long Overdue in Primary Studies of HIV-exposed Uninfected Infant Infectious Morbidity"

The Pediatric infectious disease journal

Iroh Tam, P.-Y. and Wiens, M.O. and Moschovis, P.P.

DOI: 10.1097/INF.0000000000002250

Evidence and transparency are needed to develop a frontline health worker mhealth assessment platform

American Journal of Tropical Medicine and Hygiene

Ansermino, J.M. and Wiens, M.O. and Kissoon, N.

DOI: 10.4269/ajtmh.19-0411a

A low cost mobile controlled CW-NIRS absolute oximeter to prevent child mortality in low-income countries

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Pagano, R. and Askari, S. and Petersen, C. and Beaudry, S. and Dunsmuir, D. and Wiens, M.O. and Kumbakumba, E. and Napoleone, G. and Mark Ansermino, J. and Dumont, G.A.

DOI: 10.1117/12.2510769

Exploring healthcare providers' perspectives of the paediatric discharge process in Uganda: A qualitative exploratory study

BMJ Open

Nemetchek, B. and Khowaja, A. and Kavuma, A. and Kabajaasi, O. and Olirus Owilli, A. and Ansermino, J.M. and Fowler-Kerry, S. and Jacob, S.T. and Kenya-Mugisha, N. and Kabakyenga, J. and Wiens, M.O.

DOI: 10.1136/bmjopen-2019-029526

Community health workers trained to conduct verbal autopsies provide better mortality measures than existing surveillance: Results from a cross-sectional study in rural western Uganda

PLoS ONE

Nabukalu, D. and Ntaro, M. and Seviiri, M. and Reyes, R. and Wiens, M. and Sundararajan, R. and Mulogo, E. and Boyce, R.M.

DOI: 10.1371/journal.pone.0211482

Active management of atrial fibrillation or flutter in emergency department patients with renal impairment is associated with a higher risk of adverse events and treatment failure

Canadian Journal of Emergency Medicine

Scheuermeyer, F.X. and Wong, H. and Barrett, T.W. and Christenson, J. and Grafstein, E. and Grunau, B. and Wiens, M. and Innes, G.

DOI: 10.1017/cem.2018.475

Paediatric postdischarge mortality in developing countries: a systematic review

BMJ Open

Brooklyn Nemetchek and Lacey English and Niranjan Kissoon and John Mark Ansermino and Peter P Moschovis and Jerome Kabakyenga and Susan Fowler-Kerry and Elias Kumbakumba and Matthew O Wiens

DOI: 10.1136/bmjopen-2018-023445

12 / 2018

A Locally Developed Electronic Health Platform in Uganda: Development and Implementation of Stre@mline

JMIR Formative Research

Li Liang and Matthew O Wiens and Phaisal Lubega and Ian Spillman and Samuel Mugisha

DOI: 10.2196/formative.9658

09 / 2018

A transformation of oxygen saturation (the saturation virtual shunt) to improve clinical prediction model calibration and interpretation

Guohai Zhou and Walter Karlen and Rollin Brant and Matthew Wiens and Niranjan Kissoon and J Mark Ansermino

DOI: 10.1101/391292

08 / 2018

Individual, maternal and household risk factors for anaemia among young children in sub-Saharan Africa: a cross-sectional study

BMJ Open

Peter P Moschovis and Matthew O Wiens and Lauren Arlington and Olga Antsygina and Douglas Hayden and Walter Dzik and Julius P Kiwanuka and David C Christiani and Patricia L Hibberd

DOI: 10.1136/bmjopen-2017-019654

05 / 2018

We need smarter trigger tools for diagnosing sepsis in children in Canada

CMAJ

Ansermino, J.M. and Wiens, M.O. and Kissoon, N.

DOI: 10.1503/cmaj.180434

Who stays and who goes: Predictors of admission among patients presenting with febrile illness and a positive malaria rapid diagnostic test in a rural Ugandan health center

American Journal of Tropical Medicine and Hygiene

Chang, J.L. and Reyes, R. and Matte, M. and Ntaro, M. and Mulogo, E. and Wiens, M.O. and Meshnick, S.R. and Siedner, M.J. and Boyce, R.M.

DOI: 10.4269/ajtmh.18-0338

Predictors of mortality in neonates and infants hospitalized with sepsis or serious infections in developing countries: A systematic review

Frontiers in Pediatrics

(Danny) Liang, L. and Kotadia, N. and English, L. and Kissoon, N. and Mark Ansermino, J. and Kabakyenga, J. and Lavoie, P.M. and Wiens, M.O.

DOI: 10.3389/fped.2018.00277

Pneumonia in HIV-exposed and Infected Children and Association With Malnutrition

The Pediatric infectious disease journal

Iroh Tam, P.-Y. and Wiens, M.O. and Kabakyenga, J. and Kiwanuka, J. and Kumbakumba, E. and Moschovis, P.P.

DOI: 10.1097/INF.0000000000001971

Smart hospital discharges to address a neglected epidemic in sepsis in low- and middle-income countries

JAMA Pediatrics

Wiens, M.O. and Kissoon, N. and Kabakyenga, J.

DOI: 10.1001/jamapediatrics.2017.4519

Predictor variables for post-discharge mortality modelling in infants: A protocol development project

African Health Sciences

Nemetchek, B.R. and Liang, L. and Kissoon, N. and Ansermino, J.M. and Kabakyenga, J. and Lavoie, P.M. and Fowler-Kerry, S. and Wiens, M.O.

DOI: 10.4314/AHS.V18I4.43

Development and Implementation of Stre@mline, a Locally Developed Electronic Health Platform in Uganda (Preprint)

Li Liang and Matthew O Wiens and Phisal Lubega and Ian Spillman and Samuel Mugisha

DOI: 10.2196/preprints.9658

12 / 2017

Effect of frequency of clinic visits and medication pick-up on antiretroviral treatment outcomes: A systematic literature review and meta-analysis

Journal of the International AIDS Society

Mutasa-Apollo, T. and Ford, N. and Wiens, M. and Socias, M.E. and Negussie, E. and Wu, P. and Popoff, E. and Park, J. and Mills, E.J. and Kanters, S.

DOI: 10.7448/IAS.20.5.21647

Comparative efficacy and safety of second-line antiretroviral therapy for treatment of HIV/AIDS: a systematic review and network meta-analysis

The Lancet HIV

Kanters, S. and Socias, M.E. and Paton, N.I. and Vitoria, M. and Doherty, M. and Ayers, D. and Popoff, E. and Chan, K. and Cooper, D.A. and Wiens, M.O. and Calmy, A. and Ford, N. and Nsanzimana, S. and Mills, E.J.

DOI: 10.1016/S2352-3018(17)30109-1

The authors reply

Pediatric Critical Care Medicine

Wiens, M.O. and Kissoon, N. and Moschovis, P. and Kabakyenga, J.

DOI: 10.1097/PCC.0000000000001022

Systematic Review and Meta-analysis of the Pharmacokinetics of Benznidazole in the Treatment of Chagas Disease

Antimicrobial Agents and Chemotherapy

Matthew O. Wiens and Steve Kanters and Edward Mills and Alejandro A. Peregrina Lucano and Silvia Gold and Dieter Ayers and Luis Ferrero and Alejandro Krolewiecki

DOI: 10.1128/AAC.01567-16

12 / 2016

The PAediatric Risk Assessment (PARA) Mobile App to Reduce Postdischarge Child Mortality: Design, Usability, and Feasibility for Health Care Workers in Uganda

JMIR mHealth and uHealth

Lauren Lacey English and Dustin Dunsmuir and Elias Kumbakumba and John Mark Ansermino and Charles P Larson and Richard Lester and Celestine Barigye and Andrew Ndamira and Jerome Kabakyenga and Matthew O Wiens

DOI: 10.2196/mhealth.5167

02 / 2016

Prevalence of Ethanol Use Among Pregnant Women in Southwestern Uganda

Maternal and Child Health Journal

English, L.L. and Mugyenyi, G. and Nightingale, I. and Kiwanuka, G. and Ngonzi, J. and Grunau, B.E. and MacLeod, S. and Koren, G. and Delano, K. and Kabakyenga, J. and Wiens, M.O.

DOI: 10.1007/s10995-016-2025-x

Scheduled follow-up referrals and simple prevention kits including counseling to improve post-discharge outcomes among children in Uganda: A proof-of-concept study

Global Health Science and Practice

Wiens, M.O. and Kumbakumba, E. and Larson, C.P. and Moschovis, P.P. and Barigye, C. and Kabakyenga, J. and Ndamira, A. and English, L. and Kissoon, N. and Zhou, G. and Mark Ansermino, J.A.

DOI: 10.9745/GHSP-D-16-00069

Pediatric in-hospital death from infectious disease in Uganda: Derivation of clinical prediction models

PLoS ONE

Lowlaavar, N. and Larson, C.P. and Kumbakumba, E. and Zhou, G. and Ansermino, J.M. and Singer, J. and Kissoon, N. and Wong, H. and Ndamira, A. and Kabakyenga, J. and Kiwanuka, J. and Wiens, M.O.

DOI: 10.1371/journal.pone.0150683

Selecting candidate predictor variables for the modelling of post-discharge mortality from sepsis: A protocol development project

African Health Sciences

Wiens, M.O. and Kissoon, N. and Kumbakumba, E. and Singer, J. and Moschovis, P.P. and Ansermino, J.M. and Ndamira, A. and Kiwanuka, J. and Larson, C.P.

DOI: 10.4314/ahs.v16i1.22

Application of sepsis definitions to pediatric patients admitted with suspected infections in Uganda

Pediatric Critical Care Medicine

Wiens, M.O. and Larson, C.P. and Kumbakumba, E. and Kissoon, N. and Ansermino, J.M. and Singer, J. and Wong, H. and Ndamira, A. and Kabakyenga, J. and Moschovis, P. and Kiwanuka, J.

DOI: 10.1097/PCC.0000000000000708

Pediatric out-of-hospital deaths following hospital discharge: A mixed-methods study

African Health Sciences

English, L. and Kumbakumba, E. and Larson, C.P. and Kabakyenga, J. and Singer, J. and Kissoon, N. and Ansermino, J.M. and Wong, H. and Kiwanuka, J. and Wiens, M.O.

DOI: 10.4314/ahs.v16i4.2

Emergency Department Corticosteroid Use for Allergy or Anaphylaxis Is Not Associated with Decreased Relapses

Annals of Emergency Medicine

Grunau, B.E. and Wiens, M.O. and Rowe, B.H. and McKay, R. and Li, J. and Yi, T.W. and Stenstrom, R. and Schellenberg, R.R. and Grafstein, E. and Scheuermeyer, F.X.

DOI: 10.1016/j.annemergmed.2015.03.003

Postdischarge mortality in children with acute infectious diseases: Derivation of postdischarge mortality prediction models

BMJ Open

Wiens, M.O. and Kumbakumba, E. and Larson, C.P. and Ansermino, J.M. and Singer, J. and Kissoon, N. and Wong, H. and Ndamira, A. and Kabakyenga, J. and Kiwanuka, J. and Zhou, G.

DOI: 10.1136/bmjopen-2015-009449

Mobile health applications for HIV prevention and care in Africa

Current Opinion in HIV and AIDS

Forrest, J.I. and Wiens, M. and Kanters, S. and Nsanzimana, S. and Lester, R.T. and Mills, E.J.

DOI: 10.1097/COH.0000000000000198

A cohort study of morbidity, mortality and health seeking behavior following rural health center visits by children under 12 in southwestern Uganda

PLoS ONE

Wiens, M.O. and Gan, H. and Barigye, C. and Zhou, G. and Kumbakumba, E. and Kabakyenga, J. and Kissoon, N. and Ansermino, J.M. and Karlen, W. and Larson, C.P. and MacLeod, S.M.

DOI: 10.1371/journal.pone.0118055

Critical appraisal of clinical practice guidelines in pediatric infectious diseases

International Journal of Clinical Pharmacy

Wilby, K.J. and Black, E.K. and MacLeod, C. and Wiens, M. and Lau, T.T.Y. and Paiva, M.A. and Gorman, S.

DOI: 10.1007/s11096-015-0123-2

Canadian demand for highly qualified personnel for therapeutic evaluation: An oppourtunity for academic institutions

Journal of Population Therapeutics and Clinical Pharmacology

MacLeod, S.M. and Soon, J.A. and Sharma, S. and Wiens, M.O.

Incidence of clinically important biphasic reactions in emergency department patients with allergic reactions or anaphylaxis

Annals of Emergency Medicine

Grunau, B.E. and Li, J. and Yi, T.W. and Stenstrom, R. and Grafstein, E. and Wiens, M.O. and Schellenberg, R.R. and Scheuermeyer, F.X.

DOI: 10.1016/j.annemergmed.2013.10.017

Assessing the quality of manual respiratory rate measurements using mobile devices

IET Conference Publications

Karlen, W. and Wiens, M.O. and Gan, H. and Dunsmuir, D. and Chiu, M. and Dumont, G.A. and Ansermino, J.M.

Characteristics and thirty-day outcomes of emergency department patients with elevated creatine kinase

Academic Emergency Medicine

Grunau, B.E. and Pourvali, R. and Wiens, M.O. and Levin, A. and Li, J. and Grafstein, E. and Joo, D. and Scheuermeyer, F.X.

DOI: 10.1111/acem.12385

Post-market drug evaluation research training capacity in Canada: An environmental scan of Canadian educational institutions

Journal of Population Therapeutics and Clinical Pharmacology

Wiens, M.O. and Soon, J.A. and MacLeod, S.M. and Sharma, S. and Patel, A.

Alcohol exposure among pregnant women in sub-Saharan Africa: A systematic review

Journal of Population Therapeutics and Clinical Pharmacology

Culley, C.L. and Ramsey, T.D. and Mugyenyi, G. and Kiwanuka, G.N. and Ngonzi, J. and MacLeod, S. and Koren, G. and Grunau, B.E. and Wiens, M.O.

Pediatric Post-Discharge Mortality in Resource Poor Countries: A Systematic Review

PLoS ONE

Wiens, M.O. and Pawluk, S. and Kissoon, N. and Kumbakumba, E. and Ansermino, J.M. and Singer, J. and Ndamira, A. and Larson, C.

DOI: 10.1371/journal.pone.0066698

Pediatric sepsis in the developing world: Challenges in defining sepsis and issues in post-discharge mortality

Clinical Epidemiology

Wiens, M.O. and Kumbakumba, E. and Kissoon, N. and Ansermino, J.M. and Ndamira, A. and Larson, C.P.

DOI: 10.2147/CLEP.S35693

Adherence to antiretroviral therapy in HIV-positive adolescents in uganda assessed by multiple methods: A prospective cohort study

Pediatric Drugs

Wiens, M.O. and MacLeod, S. and Musiime, V. and Ssenyonga, M. and Kizza, R. and Bakeera-Kitaka, S. and Odoi-Adome, R. and Ssali, F.

DOI: 10.2165/11599280-000000000-00000

Clinical decision rules to improve the detection of adverse drug events in Emergency Department patients

Academic Emergency Medicine

Hohl, C.M. and Yu, E. and Hunte, G.S. and Brubacher, J.R. and Hosseini, F. and Argent, C.P. and Chan, W.W.Y. and Wiens, M.O. and Sheps, S.B. and Singer, J.

DOI: 10.1111/j.1553-2712.2012.01379.x

Exposure to alternative healthcare providers and adherence to guidelines among patients with diabetes

Canadian Journal of Diabetes

Wiens, M.O. and Grunau, B.E.

DOI: 10.1016/S1499-2671(11)80007-9

Patient self-management of warfarin therapy: Pragmatic feasibility study in Canadian primary care

Canadian Family Physician

Grunau, B.E. and Wiens, M.O. and Harder, K.K.

Cocaine adulterant linked to neutropenia

CMAJ

Wiens, M.O. and Son, W.K. and Ross, C. and Hayden, M. and Carleton, B.

DOI: 10.1503/cmaj.090286

Dantrolene in the treatment of MDMA-related hyperpyrexia: A systematic review

Canadian Journal of Emergency Medicine

Grunau, B.E. and Wiens, M.O. and Brubacher, J.R.

DOI: 10.1017/S1481803500012598

Dantrolene for the treatment of MDMA toxicity

Canadian Journal of Emergency Medicine

Grunau, B.E. and Wiens, M.O. and Greidanus, M.

DOI: 10.1017/S1481803500012653

Meta-analysis of the impact of 9 medication classes on falls in elderly persons

Archives of Internal Medicine

Woolcott, J.C. and Richardson, K.J. and Wiens, M.O. and Patel, B. and Marin, J. and Khan, K.M. and Marra, C.A.

DOI: 10.1001/archinternmed.2009.357

Cesium-chloride-induced torsades de pointes

Canadian Journal of Cardiology

Wiens, M. and Gordon, W. and Baulcomb, D. and Mattman, A. and Mock, T. and Brown, R.

DOI: 10.1016/s0828-282x(09)70147-3

NSAID use and the risk of parkinsons disease: Systematic review and meta-analysis of observational studies

Drugs and Aging

Samii, A. and Etminan, M. and Wiens, M.O. and Jafari, S.

DOI: 10.2165/11316780-000000000-00000

Incidence, severity and preventability of medication-related visits to the emergency department: A prospective study

CMAJ

Zed, P.J. and Abu-Laban, R.B. and Balen, R.M. and Loewen, P.S. and Hohl, C.M. and Brubacher, J.R. and Wilbur, K. and Wiens, M.O. and Samoy, L.J. and Lacaria, K. and Purssell, R.A.

DOI: 10.1503/cmaj.071594

Use of lipid-lowering agents for the prevention of age-related macular degeneration: A meta-analysis of observational studies

Ophthalmic Epidemiology

Chuo, J.Y. and Wiens, M. and Etminan, M. and Maberley, D.A.L.

DOI: 10.1080/09286580701421684

Effects of antihypertensive drug treatments on fracture outcomes: A meta-analysis of observational studies

Journal of Internal Medicine

Wiens, M. and Etminan, M. and Gill, S.S. and Takkouche, B.

DOI: 10.1111/j.1365-2796.2006.01695.x

Adequacy of antidote stocking in British Columbia hospitals: The 2005 Antidote Stocking Study

Canadian Journal of Emergency Medicine

Wiens, M.O. and Zed, P.J. and Lepik, K.J. and Abu-Laban, R.B. and Brubacher, J.R. and Gorman, S.K. and Kent, D.A. and Purssell, R.A.

DOI: 10.1017/S1481803500014214

Evaluation of a counselling and referral-based intervention to improve post-discharge mortality for infants and children in Uganda

We are conducting two independent multisite, prospective before-and-after studies at 6 hospitals in Uganda to evaluate a counseling and referral-based intervention to improve post-discharge survival for (1) infants under 6 months of age and (2) children 6 months to 60 months of age. Briefly, these studies consist of two phases. The first phase is a model validation phase where previously derived prediction algorithms are validated and calibrated. This phase is enrolling approximately 3000 children under 6 months and 3800 children who are 6 – 60 months of age. These studies began in 2017 (6m-60m age group) and 2018 (0-6m age group) and the first phase of both of these studies has been completed. The second phase of these studies is an interventional phase, enrolling a similar number of children. This interventional phase uses the validated prediction algorithm and implements the Smart Discharges intervention, with intervention intensity based on risk. Those with lower vulnerability receive discharge counselling focused on understanding vulnerability, education on preventative practices (hygiene, mosquito net use, etc.), danger signs, and appropriate health seeking. Children at high risk receive referrals for post-discharge follow-up with community health workers or at a health facility near their residence.

Development of models to predict post-discharge outcomes among mother-baby dyads discharged after routine hospital delivery

It is a global priority to improve health of mothers and infants and to lower their mortality rates. Countries in sub-Saharan Africa bear the largest burden of maternal and newborn death, and the majority of these deaths are preventable. One third of maternal (30%) and more than half of newborn (55%) deaths occur during the first 6 weeks after birth, after a mother-newborn dyad has returned home from the hospital. To address this issue we are conducting a prospective cohort study among mothers and their newborn babies who have been discharged following a routine hospital birth. We are enrolling 3200 dyads and completing 6-week follow-up to assess post-discharge readmission and mortality. The use of dyads in this context is unique since the health of the mother and child are so intricately linked. Using candidate predictors selected through a systematic review and expert opinion we will derive a parsimonious model to identify vulnerable infant/mother pairs. This work will lead to future studies to (1) externally validate our model and (2) develop and test a Smart Discharge approach to improving outcomes in this vulnerable
group.

Grants

Thrasher Research Fund, $525,094 USD. Role: Principal Investigator. Project: Smart Discharges to improve post-discharge survival following admission for infection in young infants. Dec 1, 2020 – Nov 30, 2022.

Grand Challenges Canada, Transition to Scale, $1,000,000 CAD. Role: Principal Investigator. Project: Smart Discharges to improve post-discharge health outcomes in Uganda. Dec 1, 2017 – Jun 30, 2021.

Thrasher Research Fund, $400,000 USD. Role: Co-Principal Investigator. Project: Smart Discharges to improve post-discharge survival following admission for infection in newborns and young infants. May 2018 – Aug 2020.

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