Michael Zulyniak

(He/His)
PhD

Investigator, BC Children's Hospital

Dr. Michael Zulyniak is an Associate Professor in Human Health and Nutrition at the University of British Columbia in Vancouver, Canada. His research aims to untangle the biological, environmental, and cultural networks that underpin the disparity in metabolic health in pregnancy across ethnic groups and inform improved prevention and treatment strategies to improve maternal and offspring health outcomes. This is accomplished by harnessing the strength of research methods across nutrition, metabolism, genetics, epidemiology, and social sciences to systematically understand their intertwined relationship, effects on disease risk, and key points of mediation. Michael’s research program is cross-disciplinary by nature and includes collaborators in medicine, environmental sciences, toxicology, data sciences, public health, and molecular sciences.

Academic Affiliations

  • Associate Professor, , Department of Food, Nutrition, and Health, Faculty of Land and Food Systems, University of British Columbia
  • Research Theme: Healthy Starts
  • Research Group(s): Clinical and Community Data, Analytics and Informatics; Origins of Child Health and Disease; Pathways to Healthy Birth

Contact Information

Location

Room 248 2205 East Mall, Vancouver, BC, Canada, V6T1Z4

Plasma n-3 Polyunsaturated Fatty Acid Levels and Colorectal Cancer Risk in the UK Biobank: Evidence of Nonlinearity, as Well as Tumor Site- and Sex-Specificity

Cancer Epidemiology Biomarkers Prevention A Publication of the American Association for Cancer Research Cosponsored by the American Society of Preventive Oncology

Aldoori, J. and Zulyniak, M.A. and Toogood, G.J. and Hull, M.A.

DOI: 10.1158/1055-9965.EPI-24-1154

Evaluating modifiable hypertension risk in Nigerian adults"The Nigerian diet risk score

Tropical Medicine and International Health

Batubo, N.P. and Auma, C.I. and Moore, J.B. and Zulyniak, M.A.

DOI: 10.1111/tmi.14089

Dietary assessment and prevention of hypertension in Nigeria: Protocol for a retrospective cross-sectional study for the development and validation of a food frequency questionnaire for clinical use.

PloS one

Batubo NP and Moore JB and Zulyniak MA

DOI: 10.1371/journal.pone.0292561 PubMed: 38630757

04 / 2024

Empowering healthcare professionals in West Africa-A feasibility study and qualitative assessment of a dietary screening tool to identify adults at high risk of hypertension.

PloS one

Batubo NP and Nwanze NM and Alikor CA and Auma CI and Moore JB and Zulyniak MA

DOI: 10.1371/journal.pone.0294370 PubMed: 38662712

04 / 2024

Protein Hydrolysates and Bioactive Peptides as Mediators of Blood Glucose"A Systematic Review and Meta-Analysis of Acute and Long-Term Studies

Nutrients

Arig Elbira and Maryam Hafiz and Alan Javier Hernndez-lvarez and Michael A. Zulyniak and Christine Boesch

DOI: 10.3390/nu16020323

01 / 2024

Fish oil supplement use modifies the relationship between dietary oily fish intake and plasma n-3 PUFA levels: An analysis of the UK Biobank

British Journal of Nutrition

Aldoori, J. and Zulyniak, M.A. and Toogood, G.J. and Hull, M.A.

DOI: 10.1017/S0007114524000138

Understanding the impact of maternal and infant nutrition on infant/child health: multiethnic considerations, knowledge translation, and future directions for equitable health research

Applied Physiology, Nutrition and Metabolism

Azab, S. and Kandasamy, S. and Wahi, G. and Lamri, A. and Desai, D. and Williams, N. and Zulyniak, M. and de Souza, R. and Anand, S.S.

DOI: 10.1139/apnm-2023-0572

Validity and reproducibility of a culturally tailored dietary screening tool for hypertension risk in Nigerian healthcare

Medrxiv

Batubo, N.P. and Auma, C.I. and Moore, J.B. and Zulyniak, M.A.

DOI: 10.1101/2024.01.24.24301732

Relative Validity and Reproducibility of a Dietary Screening Tool in Nigerian Health Care

Current Developments in Nutrition

Batubo, N.P. and Auma, C.I. and Moore, J.B. and Zulyniak, M.A.

DOI: 10.1016/j.cdnut.2024.104459

The Nigerian Dietary Screening Tool: A Step toward Improved Patient-Clinician Communication in Nigerian Hospitals: A Pilot Implementation Study

Nutrients

Batubo, N.P. and Auma, C.I. and Moore, J.B. and Zulyniak, M.A.

DOI: 10.3390/nu16142286

Dietary Assessment and Prevention of Hypertension in Nigeria: Protocol for a Retrospective Cross-sectional Study for the Development and Validation of a Food Frequency Questionnaire for Clinical Use

Nimisoere P. Batubo and J. Bernadette Moore and Michael A. Zulyniak

DOI: 10.1101/2023.09.25.23296109

09 / 2023

Barriers to Exercise in Adults With Type 1 Diabetes and Insulin Resistance

Canadian Journal of Diabetes

Anwar M. Alobaid and Michael A. Zulyniak and Ramzi A. Ajjan and Jan Bro and Mark Hopkins and Matthew D. Campbell

DOI: 10.1016/j.jcjd.2023.04.016

08 / 2023

Reducing Sitting Time in Type 1 Diabetes: Considerations and Implications

Canadian Journal of Diabetes

Anwar M. Alobaid and Paddy C. Dempsey and Monique Francois and Michael A. Zulyniak and Mark Hopkins and Matthew D. Campbell

DOI: 10.1016/j.jcjd.2023.02.003

04 / 2023

Dietary factors and hypertension risk in West Africa: A systematic review and meta-analysis of observational studies

Nimisoere P. Batubo and J. Bernadette Moore and Michael A. Zulyniak

DOI: 10.1101/2023.03.21.23287434

03 / 2023

Non-Alcoholic Fatty Liver Disease and Vitamin D in the UK Biobank: A Two-Sample Bidirectional Mendelian Randomisation Study

Nutrients

Zixuan Zhang and Kimberley Burrows and Harriett Fuller and Elizabeth K. Speliotes and Kushala W. M. Abeysekera and James L. Thorne and Sarah J. Lewis and Michael A. Zulyniak and J. Bernadette Moore

DOI: 10.3390/nu15061442

03 / 2023

Protocol for the INFORMED (Individualised Patient Care and Treatment for Maternal Diabetes) Study: a randomised controlled trial embedded within routine care

BMJ Open

Cassy F Dingena and Anvesha Mahendra and Melvin J Holmes and Naomi S Clement and Eleanor M Scott and Michael A Zulyniak

DOI: 10.1136/bmjopen-2022-065388

02 / 2023

Nutritional and Exercise-Focused Lifestyle Interventions and Glycemic Control in Women with Diabetes in Pregnancy: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Nutrients

Cassy F. Dingena and Daria Arofikina and Matthew D. Campbell and Melvin J. Holmes and Eleanor M. Scott and Michael A. Zulyniak

DOI: 10.3390/nu15020323

01 / 2023

A culturally tailored personaliseD nutrition intErvention in South ASIan women at risk of Gestational Diabetes Mellitus (DESI-GDM): a randomised controlled trial protocol

BMJ Open

Stennett, R.N. and Adamo, K.B. and Anand, S.S. and Bajaj, H.S. and Bangdiwala, S.I. and Desai, D. and Gerstein, H.C. and Kandasamy, S. and Khan, F. and Lear, S.A. and McDonald, S.D. and Pocsai, T. and Ritvo, P. and Rogge, A. and Schulze, K.M. and Sherifali, D. and Stearns, J.C. and Wahi, G. and Williams, N.C. and Zulyniak, M.A. and De Souza, R.J.

DOI: 10.1136/bmjopen-2023-072353

Interrupting prolonged sitting with frequent short bouts of light-intensity activity improves time in range in people with type 1 diabetes

Diabetic Medicine

Metabolic drivers of dysglycemia in pregnancy: ethnic-specific GWAS of 146 metabolites and 1-sample Mendelian randomization analyses in a UK multi-ethnic birth cohort

Frontiers in Endocrinology

Fuller, H. and Iles, M.M. and Moore, J.B. and Zulyniak, M.A.

DOI: 10.3389/fendo.2023.1157416

Empowering Healthcare Professionals in West Africa - A Feasibility Study and Qualitative Assessment of a Dietary Screening Tool to Identify Adults at High Risk of Hypertension

Medrxiv

Batubo, N.P. and Nwanze, N.M. and Alikor, C.A. and Auma, C.I. and Moore, J.B. and Zulyniak, M.A.

DOI: 10.1101/2023.11.09.23297914

Metabolic Drivers of Dysglycemia in Pregnancy: Ethnic-Specific GWAS of 146 Metabolites and 1-Sample Mendelian Randomisation Analyses in a UK Multi-Ethnic Birth Cohort

Harriett Fuller and Mark M Iles and J. Bernadette Moore and Michael A. Zulyniak

DOI: 10.1101/2022.12.21.22283768

12 / 2022

Unique Metabolic Profiles Associate with Gestational Diabetes and Ethnicity in Low- and High-Risk Women Living in the UK

The Journal of Nutrition

Harriett Fuller and Mark Iles and J Bernadette Moore and Michael A Zulyniak

DOI: 10.1093/jn/nxac163

10 / 2022

Observational assessments of the relationship of dietary and pharmacological treatment on continuous measures of dysglycemia over 24 hours in women with gestational diabetes

Cassy F. Dingena and Melvin J. Holmes and Matthew D. Campbell and Janet E. Cade and Eleanor M. Scott and Michael A. Zulyniak

DOI: 10.1101/2022.09.16.22280027

09 / 2022

Unique Metabolic Profiles Associate with Gestational Diabetes and Ethnicity in Low and High-Risk Women Living in the UK

Harriett Fuller and Mark Iles and J. Bernadette Moore and Michael A. Zulyniak

DOI: 10.1101/2022.04.11.22273658

04 / 2022

Investigation of the association between high arachidonic acid synthesis and colorectal polyp incidence: a Mendelian randomisation approach

Rachel Moon and J. Bernadette Moore and Mark A. Hull and Michael A. Zulyniak

DOI: 10.1101/2022.04.11.22273669

04 / 2022

Barriers to exercise in type 1 diabetes individuals with insulin resistance

Diabetologia

Phytosterols and phytostanols and the hallmarks of cancer in model organisms: A systematic review and meta-analysis

Critical Reviews in Food Science and Nutrition

Cioccoloni, G. and Soteriou, C. and Websdale, A. and Wallis, L. and Zulyniak, M.A. and Thorne, J.L.

DOI: 10.1080/10408398.2020.1835820

Characterizing Adolescents' Dietary Intake by Taste: Results From the UK National Diet and Nutrition Survey

Frontiers in Nutrition

Bawajeeh, A. and Zulyniak, M.A. and Evans, C.E.L. and Cade, J.E.

DOI: 10.3389/fnut.2022.893643

Investigation of the Association between High Arachidonic Acid Synthesis and Colorectal Polyp Incidence within a Generally Healthy UK Population: A Mendelian Randomization Approach

Lifestyle Genomics

Rachel Moon and J. Bernadette Moore and Mark A. Hull and Michael A. Zulyniak

DOI: 10.1159/000526447

Ethnic-specific associations between dietary consumption and gestational diabetes mellitus incidence: A meta-analysis

Plos Global Public Health

Fuller, H. and Moore, J.B. and Iles, M.M. and Zulyniak, M.A.

DOI: 10.1371/journal.pgph.0000250

DNA methylation changes in cord blood and the developmental origins of health and disease " a systematic review and replication study

BMC Genomics

Akhabir, L. and Stringer, R. and Desai, D. and Mandhane, P.J. and Azad, M.B. and Moraes, T.J. and Subbarao, P. and Turvey, S.E. and Par, G. and Anand, S.S. and Anand, S.S. and Atkinson, S.A. and Becker, A.B. and Brook, J. and Denburg, J.A. and de Souza, R.J. and Gupta, M. and Kobor, M. and Lefebvre, D.L. and Lou, W. and Mandhane, P.J. and McDonald, S. and Mente, A. and Meyre, D. and Moraes, T.J. and Morrison, K. and Sears, M.R. and Teo, K.K. and Wilson, J. and Yusuf, S. and Atkinson, S. and Wahi, G. and Zulyniak, M.A.

DOI: 10.1186/s12864-022-08451-6

Corrigendum: Characterizing adolescents' dietary intake by taste: Results from the UK National Diet and Nutrition Survey(Front. Nutr., (2022), 9, (893643), 10.3389/fnut.2022.893643)

Frontiers in Nutrition

Bawajeeh, A. and Zulyniak, M.A. and Evans, C.E.L. and Cade, J.E.

DOI: 10.3389/fnut.2022.1046893

Pharmacologic and genetic inhibition of cholesterol esterification enzymes reduces tumour burden: a systematic review and meta-analysis of preclinical models.

Biochemical pharmacology

Websdale A and Kiew Y and Chalmers P and Chen X and Cioccoloni G and Hughes TA and Luo X and Mwarzi R and Poirot M and Rberg-Larsen H and Wu R and Xu M and Zulyniak MA and Thorne JL

DOI: 10.1016/j.bcp.2021.114731 PubMed: 34407453

08 / 2021

Studies to Improve Perinatal Health through Diet and Lifestyle among South Asian Women Living in Canada: A Brief History and Future Research Directions

Nutrients

Dipika Desai and Sujane Kandasamy and Jayneel Limbachia and Michael Zulyniak and Paul Ritvo and Diana Sherifali and Gita Wahi and Sonia S. Anand and Russell de Souza

DOI: 10.3390/nu13092932

08 / 2021

Dietary and supplemental long-chain omega-3 fatty acids as moderators of cognitive impairment and Alzheimer's disease.

European journal of nutrition

Wood AHR and Chappell HF and Zulyniak MA

DOI: 10.1007/s00394-021-02655-4 PubMed: 34392394

08 / 2021

Pharmacologic and genetic inhibition of cholesterol esterification reduces tumour burden: A pan-cancer systematic review and meta-analysis of preclinical models

bioRxiv

Websdale, A. and Kiew, Y. and Chalmers, P. and Chen, X. and Cioccoloni, G. and Hughes, T.A. and Luo, X. and Mwarzi, R. and Poirot, M. and R?berg-Larsen, H. and Wu, R. and Xu, M. and Zulyniak, M.A. and Thorne, J.L.

DOI: 10.1101/2021.06.12.448188

Development of an Arabic food composition database for use in an Arabic online dietary assessment tool (myfood24)

Journal of Food Composition and Analysis

Bawajeeh, A. and Kalendar, S. and Scarpa, G. and Hancock, N. and Beer, S. and Gibson, L. and Williams, G. and Dashti, B. and Albar, S. and Ensaff, H. and Zulyniak, M.A. and Evans, C.E. and Cade, J.E.

DOI: 10.1016/j.jfca.2021.104047

Ethnic differences in maternal diet in pregnancy and infant eczema (vol 15, e0232170, 2020)

Plos One

DOI: 10.1371/JOURNAL.PONE.0246481

Impact of taste on food choices in adolescence" systematic review and meta-analysis

Nutrients

Bawajeeh, A.O. and Albar, S.A. and Zhang, H. and Zulyniak, M.A. and Evans, C.E.L. and Cade, J.E.

DOI: 10.3390/nu12071985

Predictive metabolomic profiling within a diverse population of pregnant women at low or high risk of gestational diabetes

Proceedings of the Nutrition Society

Fuller, H. and Moore, J.B. and Iles, M. and Zulyniak, M.

DOI: 10.1017/S002966512000765X

Ethnic differences in maternal diet in pregnancy and infant eczema

PLoS ONE

Zulyniak, M.A. and de Souza, R.J. and Shaikh, M. and Ramasundarahettige, C. and Tam, K. and William, N. and Desai, D. and Lefebvre, D.L. and Gupta, M. and Subbarao, P. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Moraes, T. and Azad, M.B. and Teo, K.K. and Sears, M.R. and Anand, S.S. and Atkinson, S.A. and Azad, M.B. and Becker, A.B. and Brook, J. and Denburg, J. and Desai, D. and de Souza, R.J. and Gupta, M. and Kobor, M. and Lefebvre, D.L. and Lou, W. and Mandhane, P.J. and McDonald, S. and Mente, A. and Meyre, D. and Moraes, T.J. and Morrison, K. and Par, G. and Sears, M.R. and Subbarao, P. and Teo, K.K. and Turvey, S.E. and Wilson, J. and Yusuf, S. and Atkinson, S. and Wahi, G. and Zulyniak, M.A.

DOI: 10.1371/journal.pone.0232170

Erratum: A whey protein-based multiingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial (PLoS ONE (2017) 12:7 (e0181387) DOI: 10.1371/journal.pone.0181387)

PLoS ONE

Bell, K.E. and Snijders, T. and Zulyniak, M. and Kumbhare, D. and Parise, G. and Chabowski, A. and Phillips, S.M.

DOI: 10.1371/journal.pone.0243876

Investigation of the Causal Association between Long-Chain n-6 Polyunsaturated Fatty Acid Synthesis and the Risk of Type 2 Diabetes: A Mendelian Randomization Analysis

Lifestyle Genomics

Zulyniak, M.A. and Fuller, H. and Iles, M.M.

DOI: 10.1159/000509663

Correction to: A multi-ingredient nutritional supplement enhances exercise training-related reductions in markers of systemic inflammation in healthy older men(Appl. physiol. nutr. metab. 43, 3: 299-302, 2018,10.1139/apnm-2017-0533)

Applied Physiology, Nutrition and Metabolism

Bell, K.E. and Snijders, T. and Zulyniak, M.A. and Kumbhare, D. and Parise, G. and Chabowski, A. and Phillips, S.M.

DOI: 10.1139/apnm-2020-0763

Corrigendum: A Multi-Ingredient Nutritional Supplement in Combination With Resistance Exercise and High-Intensity Interval Training Improves Cognitive Function and Increases N-3 Index in Healthy Older Men: A Randomized Controlled Trial (Front.Aging Neurosci., (2019) 11, (107), 10.3389/fnagi.2019.00107)

Frontiers in Aging Neuroscience

Bell, K.E. and Fang, H. and Snijders, T. and Allison, D.J. and Zulyniak, M.A. and Chabowski, A. and Parise, G. and Phillips, S.M. and Heisz, J.J.

DOI: 10.3389/fnagi.2020.611387

Metabolic Trajectories Following Contrasting Prudent and Western Diets from Food Provisions: Identifying Robust Biomarkers of Short-Term Changes in Habitual Diet.

Nutrients

Wellington N and Shanmuganathan M and de Souza RJ and Zulyniak MA and Azab S and Bloomfield J and Mell A and Ly R and Desai D and Anand SS and Britz-McKibbin P

DOI: 10.3390/nu11102407 PubMed: 31600930

10 / 2019

Metabolic Trajectories Following Contrasting Prudent and Western Diets from Food Provisions: Robust Biomarkers of Short-Term Changes in Habitual Diet

Wellington N and Shanmuganathan M and de Souza RJ and Zulyniak MA and Azab S and Bloomfield J and Mell A and Ly R and Desai D and Anand SS and Britz-McKibbin P

DOI: 10.20944/preprints201908.0149.v1

08 / 2019

A multi-ingredient nutritional supplement in combination with resistance exercise and high-intensity interval training improves cognitive function and increases n-3 index in healthy older men: A randomized controlled trial

Frontiers in Aging Neuroscience

Bell, K.E. and Fang, H. and Snijders, T. and Allison, D.J. and Zulyniak, M.A. and Chabowski, A. and Parise, G. and Phillips, S.M. and Heisz, J.J.

DOI: 10.3389/fnagi.2019.00107

The influence of maternal and infant nutrition on cardiometabolic traits: Novel findings and future research directions from four Canadian birth cohort studies

Proceedings of the Nutrition Society

De Souza, R.J. and Zulyniak, M.A. and Stearns, J.C. and Wahi, G. and Teo, K. and Gupta, M. and Sears, M.R. and Subbarao, P. and Anand, S.S.

DOI: 10.1017/S0029665119000612

A multi-ingredient nutritional supplement enhances exercise training-related reductions in markers of systemic inflammation in healthy older men

Applied Physiology, Nutrition and Metabolism

Bell, K.E. and Snijders, T. and Zulyniak, M.A. and Kumbhare, D. and Parise, G. and Chabowski, A. and Phillips, S.M.

DOI: 10.1139/apnm-2017-0533

Lifestyle Genomics: Addressing the Multifactorial Nature of Personalized Health

Lifestyle Genomics

Mutch, D.M. and Zulyniak, M.A. and Rudkowska, I. and Tejero, M.E.

DOI: 10.1159/000492297

Causes and consequences of gestational diabetes in South Asians living in Canada: results from a prospective cohort study.

CMAJ open

PubMed: 28800568

08 / 2017

Causes and consequences of gestational diabetes in South Asians living in Canada: results from a prospective cohort study

CMAJ open

Anand, S.S. and Gupta, M. and Teo, K.K. and Schulze, K.M. and Desai, D. and Abdalla, N. and Zulyniak, M. and de Souza, R. and Wahi, G. and Shaikh, M. and Beyene, J. and de Villa, E. and Morrison, K. and McDonald, S.D. and Gerstein, H.

DOI: 10.9778/cmajo.20170027

Ethnic and diet-related differences in the healthy infant microbiome

Genome Medicine

Stearns, J.C. and Zulyniak, M.A. and de Souza, R.J. and Campbell, N.C. and Fontes, M. and Shaikh, M. and Sears, M.R. and Becker, A.B. and Mandhane, P.J. and Subbarao, P. and Turvey, S.E. and Gupta, M. and Beyene, J. and Surette, M.G. and Anand, S.S.

DOI: 10.1186/s13073-017-0421-5

A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial

PLoS ONE

Bell, K.E. and Snijders, T. and Zulyniak, M. and Kumbhare, D. and Parise, G. and Chabowski, A. and Phillips, S.M.

DOI: 10.1371/journal.pone.0181387

Does the impact of a plant-based diet during pregnancy on birth weight differ by ethnicity? A dietary pattern analysis from a prospective Canadian birth cohort alliance

BMJ Open

Zulyniak, M.A. and De Souza, R.J. and Shaikh, M. and Desai, D. and Lefebvre, D.L. and Gupta, M. and Wilson, J. and Wahi, G. and Subbarao, P. and Becker, A.B. and Mandhane, P. and Turvey, S.E. and Beyene, J. and Atkinson, S. and Morrison, K.M. and McDonald, S. and Teo, K.K. and Sears, M.R. and Anand, S.S.

DOI: 10.1136/bmjopen-2017-017753

Fish oil regulates blood fatty acid composition and oxylipin levels in healthy humans: A comparison of young and older men

Molecular Nutrition and Food Research

Zulyniak, M.A. and Roke, K. and Gerling, C. and Logan, S.L. and Spriet, L.L. and Mutch, D.M.

DOI: 10.1002/mnfr.201500830

Harmonization of food-frequency questionnaires and dietary pattern analysis in 4 ethnically diverse birth cohorts

Journal of Nutrition

de Souza, R.J. and Zulyniak, M.A. and Desai, D. and Shaikh, M.R. and Campbell, N.C. and Lefebvre, D.L. and Gupta, M. and Wilson, J. and Wahi, G. and Atkinson, S.A. and Teo, K.K. and Subbarao, P. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Sears, M.R. and Anand, S.S. and Beyene, J. and Denburg, J.A. and McDonald, S. and Mente, A. and Meyre, D. and Morrison, K. and Pare, G. and Surette, M.

DOI: 10.3945/jn.116.236729

A randomized controlled trial of the effects of a prudent diet on cardiovascular risk factors, gene expression, and DNA methylation - The Diet and Genetic Intervention (DIGEST) Pilot study

BMC Nutrition

Zulyniak, M.A. and De Souza, R.J. and Mente, A. and Kandasamy, S. and Nundy, M. and Desai, D. and Raman, K. and Hasso, R. and Pare, G. and Beyene, J. and Anand, S.S.

DOI: 10.1186/s40795-016-0074-6

Molecular insights into the role of white adipose tissue in metabolically unhealthy normal weight and metabolically healthy obese individuals

FASEB Journal

Badoud, F. and Perreault, M. and Zulyniak, M.A. and Mutch, D.M.

DOI: 10.1096/fj.14-263913

Erratum: Food Consumption and its Impact on Cardiovascular Disease: Importance of Solutions Focused on the Globalized Food System: A Report From the Workshop Convened by the World Heart Federation (J Am Coll Cardiol (2015) 66 (1590-1614))

Journal of the American College of Cardiology

Anand, S.S. and Hawkes, C. and De Souza, R.J. and Mente, A. and Dehghan, M. and Nugent, R. and Zulyniak, M.A. and Weis, T. and Bernstein, A.M. and Krauss, R.M. and Kromhout, D. and Jenkins, D.J.A. and Malik, V. and Martinez-Gonzalez, M.A. and Mozaffarian, D. and Yusuf, S. and Willett, W.C. and Popkin, B.M.

DOI: 10.1016/j.jacc.2015.09.052

Metabolomics reveals metabolically healthy and unhealthy obese individuals differ in their response to a caloric challenge

PLoS ONE

Badoud, F. and Lam, K.P. and Perreault, M. and Zulyniak, M.A. and Britz-McKibbin, P. and Mutch, D.M.

DOI: 10.1371/journal.pone.0134613

Food Consumption and its Impact on Cardiovascular Disease: Importance of Solutions Focused on the Globalized Food System A Report from the Workshop Convened by the World Heart Federation

Journal of the American College of Cardiology

Anand, S.S. and Hawkes, C. and De Souza, R.J. and Mente, A. and Dehghan, M. and Nugent, R. and Zulyniak, M.A. and Weis, T. and Bernstein, A.M. and Krauss, R.M. and Kromhout, D. and Jenkins, D.J.A. and Malik, V. and Martinez-Gonzalez, M.A. and Mozaffarian, D. and Yusuf, S. and Willett, W.C. and Popkin, B.M.

DOI: 10.1016/j.jacc.2015.07.050

Serum fatty acid profiling within distinct lipid fractions provides a more robust indicator of insulin resistance in humans than total triglyceride and fatty acid profiles

Appl. Physiol. Nutr. Metab.

Michael A. Zulyniak

DOI: 10.1139/apnm-2014-0136

10 / 2014

A distinct fatty acid profile underlies the reduced inflammatory state of metabolically healthy obese individuals

PLoS ONE

Perreault, M. and Zulyniak, M.A. and Badoud, F. and Stephenson, S. and Badawi, A. and Buchholz, A. and Mutch, D.M.

DOI: 10.1371/journal.pone.0088539

Serum and adipose tissue amino acid homeostasis in the metabolically healthy obese

Journal of Proteome Research

Badoud, F. and Lam, K.P. and Dibattista, A. and Perreault, M. and Zulyniak, M.A. and Cattrysse, B. and Stephenson, S. and Britz-Mckibbin, P. and Mutch, D.M.

DOI: 10.1021/pr500416v

Fish oil supplementation alters circulating eicosanoid concentrations in young healthy men

Metabolism: Clinical and Experimental

Zulyniak, M.A. and Perreault, M. and Gerling, C. and Spriet, L.L. and Mutch, D.M.

DOI: 10.1016/j.metabol.2013.02.004

Ethnic- and sex-specific associations between plasma fatty acids and markers of insulin resistance in healthy young adults

Nutrition and Metabolism

Ralston, J.C. and Zulyniak, M.A. and Nielsen, D.E. and Clarke, S. and Badawi, A. and El-Sohemy, A. and Ma, D.W. and Mutch, D.M.

DOI: 10.1186/1743-7075-10-42

Vaccenic acid in serum triglycerides is associated with markers of insulin resistance in men

Applied Physiology, Nutrition and Metabolism

Zulyniak, M.A. and Ralston, J.C. and Tucker, A.J. and MacKay, K.A. and Hillyer, L.M. and McNicholas, P.D. and Graham, T.E. and Robinson, L.E. and Duncan, A.M. and Ma, D.W.L. and Mutch, D.M.

DOI: 10.1139/H2012-081

The relationship between plasma fatty acids and risk factors for insulin resistance in men

Canadian Journal of Diabetes

M.A. Zulyniak and J.C. Ralston and A.J. Tucker and K.A. MacKay and L. Hillyer and P.D. McNicholas and T.E. Graham and L.E. Robinson and A.M. Duncan and D.W.L. Ma and D.M. Mutch

DOI: 10.1016/s1499-2671(11)52249-x

01 / 2011

Harnessing metabolomics for nutrition research

Current Pharmaceutical Biotechnology

Zulyniak, M.A. and Mutch, D.M.

DOI: 10.2174/138920111795909113

GenetiC and Lifestyle DeterminAnts of Newborn BiRthweight and AdIposiTY (CLARITY)

There is an inverse association between birth weight (across most of its distribution) and health in adulthood. This is likely a reflection of maternal and offspring genetics, intrauterine environments, and foetal exposures, which collectively regulate the intrauterine environment and newborn anthropometrics. Studies suggest that maternal and foetal genetics both contribute to newborn anthropometrics but we’ve yet to understand their distinct effects on newborn anthropometrics . This is the first study to construct ethnic specific polygenic risk scores for birth weight and adiposity in South Asians and white Europeans living in the Canada and the UK and will shed light on the unique maternal and offspring genetic contributors and lifestyle moderators of newborn birth weight and adiposity in each ethnic group.

Omics Integration of Pregnancy Trajectories (OMNI-PREG)

Globally, gestational diabetes (GDM) is the most common pregnancy complication, affecting up to one in every seven births; however, its prevalence varies between ethnic groups, irrespective of BMI and country of residence. Furthermore, women who develop GDM are more likely to develop diabetes in later life and their offspring are more likely to devleop obesity and diabetes in later life. Factors driving this disparity in prevalence are not fully understood but undelrying biology is thought to play a key role, given ours and other’s work that demonstrates (i) differences in metabolic profiles between GDM and non-GDM pregnancies in an ethnic-specific manner; and (ii) that a single dietary strategy to manage GDM across all ethnic groups appears ineffective. This study harnesses the strengths of genetic, metabolite, lifestyle, and clinical data to offer a clear and accurate understanding of ethnic-specific metabolic drivers of gestational dysglycemia that can inform appropriate and effective prevention and management strategies across ethnic groups.

Recovery of Maternal Body Compositon and Glycemic Stability from Dairy-Derived Nutrients (RESET)

The effect of diabetes on pregnant women is becoming a global health problem that is linked to short and long-term health risks for the mother and her baby. Although many women with diabetes manage to control their blood glucose levels during pregnancy, up to 50% of women struggle to follow lifestyle and clinical guidelines and experience episodes of high blood glucose levels. With global health groups predicting that over 12 million pregnant women will be diabetic within 8 years, finding new and better ways to support pregnant women with diabetes is crucial to minimise short- and long-term risks for pregnant women and their babies. The most common requests from pregnant women with diabetes are guidelines that are easy to follow and personalised advice that fits a busy schedule. Work from our lab offers two solutions to deliver on these requests: (1) high protein diets offer a manageable solution to lower blood glucose in women with diabetes; and (2) by measuring metabolism in the body we identify women at greatest risk of dysglycemia during pregnancy. This study aims to demonstrate the value of these tools to support pregnant women with diabetes and the health of their babies.

Grants

Principle Investigator. Omics Integration of Pregnancy Trajectories (OMNI-PREG). Funding Source: UBC (Land and Food Systems)

Principle Investigator. Omics data as predictor of Child Growth Trajectory. Funding Source: Dekaban Foundation

Principle Investigator. GenetiC and Lifestyle DeterminAnts of Newborn BiRthweight and AdIposiTY (CLARITY). Funding Source: Biotechnology and Biological Sciences Research Council (BBSRC, UK)

Principle Investigator. Early maternal predictors of infant birth weight and adult cardiometabolic risk in South Asians. Funding Source: Wellcome UK

Co-Investigator. A culturally-tailored personalizeD nutrition intErvention in South Asian women at risk of Gestational Diabetes Mellitus: a randomized trial (DESI-GDM). Funding Source: Canadian Institute for Health Research (CIHR)

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