New research from BC Children’s Hospital Research Institute and the University of British Columbia (UBC) reveals a safe path to overcoming food allergies for older children or building resistance for those who can’t risk consuming allergens.
It’s called sublingual immunotherapy (SLIT), and it involves placing small amounts of food allergens under the tongue.
A study conducted by Dr. Edmond Chan, a pediatric allergist at BC Children’s and UBC clinical professor, and his team found SLIT to be as safe and effective for high-risk older children and adolescents as oral immunotherapy is for preschoolers.
“Our work confirms the safety and effectiveness of SLIT for older children and adolescents with multiple food allergies at higher risk of severe reaction.” — Dr. Chan.
“These are patients for whom oral immunotherapy would typically be denied because it’s felt to be too risky, so this could be the best approach for that population,” says Dr. Chan
Previously published research from Dr. Chan’s team has shown that preschool oral immunotherapy is safe and effective in the real world. The protocol involves a “build-up phase” of several months, when patients visit a clinic every two weeks to ingest a higher dose of an allergen under medical supervision before continuing the same daily dose between visits. When they reach a certain dose — usually around 300 mg of protein — they enter a “maintenance phase” during which they take that target daily dose at home. After a year of maintenance doses, approximately four out of five patients are able to pass an oral challenge test in which they tolerate a much higher dose of 4,000 mg of protein.
However, the build-up phase is risky for older children and those with a history of severe reactions. Dr. Chan’s group has been looking for a safer way to get this at-risk group of patients to the maintenance phase.
They recruited about 180 such patients between the ages of four and 18, most with multiple food allergies. The SLIT protocol (started when COVID-19 pandemic restrictions were in place) required patients to have virtually supervised appointments three to five times over several months to build up to a small dose — in most cases, just two mg of protein — which is absorbed through the membranes under the tongue rather than swallowed and ingested.
The patients’ caregivers learned how to mix and administer these doses at home using novel recipes based on products you can buy at the grocery store, developed with the team’s research dietitian. A wide variety of allergens were treated, including peanut, other legumes, tree nuts, sesame, other seeds, egg, cow’s milk, fish, wheat, shrimp, and other allergens. Patients took these doses daily for one to two years.
“It takes up to twice as long as oral immunotherapy, but we wouldn’t have had it any other way because we needed the superior safety of SLIT for these older kids that are felt to be more severe,” says Dr. Chan.
While most patients had mild symptoms during the build-up phase, none had severe reactions during either the build-up or maintenance stages. Seventy per cent of those tested at the end of the protocol could tolerate 300 mg of their allergen — a success rate nearly as high as that for oral immunotherapy.
The results were encouraging for a therapy that any family can undertake at home with guidance from professionals.
“Besides safety considerations in older children, allergists are often quite burdened by the oral immunotherapy build-up phase, where a patient may require 11 or more visits to the clinic. They just don’t feel they have the capacity to offer that many visits in their office,” says Dr. Chan. “In our clinic, we are starting to do more home-based approaches because the demand for medical appointments that would allow supervision far outstrips the supply. We are trying to develop an approach, based on data, that matches a patient’s risk level with the appropriate amount of supervision. Our SLIT data suggests that home-based SLIT build-up is safe.”
Ultimately, the trial highlights an alternative that allergists should now consider for patients who cannot safely undertake oral immunotherapy. The trade-off for greater safety is simply a longer timeline, but it comes with the benefit of keeping clinics free for those who need them most.
Credit: UBC Media Relations news release
