Overview

1. Food allergy

My research encompasses all clinical aspects of food allergy, including prevention, diagnosis, and management.

Selected projects include:

Characterizing current practices among pediatricians, dietitians, family physicians, and parents on dietary exposures and allergy prevention

Bridging the gap between research findings and translation into clinical care. I have taken an active role nationally in health advocacy as lead author of the first Canadian position statement on allergy prevention and dietary exposure in high-risk infants, representing both the Canadian Paediatric Society and the Canadian Society of Allergy & Clinical Immunology (CSACI). My roles with the CSACI as past Pediatric section head and current Board of director have facilitated this work, which has now expanded to unified efforts with U.S. and international colleagues. We continue to work on initiatives locally in BC as well.

Utility of Ara h 2 component testing for peanut allergy diagnosis in Canadian children

Creation and investigation of an e-Health tool, for education of the general public on proper food allergy diagnosis

Confidence, knowledge, and skill with use of epinephrine auto-injectors for management of food allergy

The impact of pediatric allergist care on the quality of life of children with food allergy

Collaborator on CIHR / AllerGen sponsored food allergy registry studies (peanut, seafood), with colleagues at the University of Calgary and McGill

Collaborator on CIHR / AllerGen sponsored food immunotherapy studies (cow’s milk desensitization), with colleagues at McGill and other sites

2. Eosinophilic Esophagitis (EoE)

In 2012, I helped to create the multi-disciplinary EoE Clinic at BC Children’s Hospital, one of the only clinics dedicated to EoE in Canada. Dr. Vishal Avinashi (Gastroenterology) and I are both co-directors of the clinic.

The clinic has had several research pursuits, including the following projects:

EoE Registry – a prospectively collected registry with clinical data, including allergy, gastrointestinal, and nutritional parameters

Characterization of ethnicity for childhood EoE in BC

Cow’s milk elimination for management of EoE

Adrenal suppression among children being treated for EoE

Publications

Early Solid Food Introduction: Role in Food Allergy Prevention and Implications for Breastfeeding
The Journal of Pediatrics
Elissa M. Abrams, Matthew Greenhawt, David M. Fleischer, Edmond S. Chan
DOI: 10.1016/j.jpeds.2017.01.053
05/2017

Utility of Ara h 2 sIgE levels to predict peanut allergy in Canadian children
The Journal of Allergy and Clinical Immunology: In Practice
Sara H. Leo, John M. Dean, Benjamin Jung, Boris Kuzeljevic, Edmond S. Chan
DOI: 10.1016/j.jaip.2015.04.001
11/2015

Consensus Communication on Early Peanut Introduction and Prevention of Peanut Allergy in High-Risk Infants
Pediatr Dermatol
David M. Fleischer, Scott Sicherer, Matthew Greenhawt, Dianne Campbell, Edmond Chan, Antonella Muraro, Susanne Halken, Yitzhak Katz, Motohiro Ebisawa, Lawrence Eichenfield, Hugh Sampson, Gideon Lack, George Du Toit, Graham Roberts, Henry Bahnson, Mary Feeney, Jonathan Hourihane, Jonathan Spergel, Michael Young, Amal As'aad, Katrina Allen, Susan Prescott, Sandeep Kapur, Hirohisa Saito, Ioana Agache, Cezmi A. Akdis, Hasan Arshad, Kirsten Beyer, Anthony Dubois, Philippe Eigenmann, Monserrat Fernandez-Rivas, Kate Grimshaw, Karin Hoffman-Sommergruber, Arne Host, Susanne Lau, Liam O'Mahony, Clare Mills, Nikolaus Papadopoulos, Carina Venter, Nancy Agmon-Levin, Aaron Kessel, Richard Antaya, Beth Drolet, Lanny Rosenwasser
DOI: 10.1111/pde.12685
09/2015

Characterization of ethnicity among children with eosinophilic esophagitis in British Columbia, Canada
The Journal of Allergy and Clinical Immunology: In Practice
Timothy Teoh, Chris Koo, Vishal Avinashi, Edmond S. Chan
DOI: 10.1016/j.jaip.2015.04.016
09/2015

Consensus communication on early peanut introduction and the prevention of peanut allergy in high-risk infants
Allergy Asthma Clin Immunol
David M. Fleischer, FOR THE LEAP TRIAL TEAM, Scott Sicherer, Matthew Greenhawt, Dianne Campbell, Edmond S. Chan, Antonella Muraro, Susanne Halken, Yitzhak Katz, Motohiro Ebisawa, Lawrence Eichenfield, Hugh Sampson, SECONDARY CONTRIBUTORS
DOI: 10.1186/s13223-015-0087-8
08/2015

Consensus communication on early peanut introduction and the prevention of peanut allergy in high-risk infants
Annals of Allergy, Asthma & Immunology
David M. Fleischer, Scott Sicherer, Matthew Greenhawt, Dianne Campbell, Edmond Chan, Antonella Muraro, Susanne Halken, Yitzhak Katz, Motohiro Ebisawa, Lawrence Eichenfield, Hugh Sampson, Gideon Lack, George Du Toit, Graham Roberts, Henry Bahnson, Mary Feeney, Jonathan Hourihane, Jonathan Spergel, Michael Young, Amal As'aad, Katrina Allen, Susan Prescott, Sandeep Kapur, Hirohisa Saito, Ioana Agache, Cezmi A. Akdis, Hasan Arshad, Kirsten Beyer, Anthony Dubois, Philippe Eigenmann, Monserrat Fernandez-Rivas, Kate Grimshaw, Karin Hoffman-Sommergruber, Arne Host, Susanne Lau, Liam O'Mahony, Clare Mills, Nikolaus Papadopoulos, Carina Venter, Nancy Agmon-Levin, Aaron Kessel, Richard Antaya, Beth Drolet, Lanny Rosenwasser
DOI: 10.1016/j.anai.2015.06.001
08/2015

Consensus communication on early peanut introduction and the prevention of peanut allergy in high-risk infants
Journal of Allergy and Clinical Immunology
David M. Fleischer, Scott Sicherer, Matthew Greenhawt, Dianne Campbell, Edmond Chan, Antonella Muraro, Susanne Halken, Yitzhak Katz, Motohiro Ebisawa, Lawrence Eichenfield, Hugh Sampson, Gideon Lack, George Du Toit, Graham Roberts, Henry Bahnson, Mary Feeney, Jonathan Hourihane, Jonathan Spergel, Michael Young, Amal As'aad, Katrina Allen, Susan Prescott, Sandeep Kapur, Hirohisa Saito, Ioana Agache, Cezmi A. Akdis, Hasan Arshad, Kirsten Beyer, Anthony Dubois, Philippe Eigenmann, Monserrat Fernandez-Rivas, Kate Grimshaw, Karin Hoffman-Sommergruber, Arne Host, Susanne Lau, Liam O'Mahony, Clare Mills, Nikolaus Papadopoulos, Carina Venter, Nancy Agmon-Levin, Aaron Kessel, Richard Antaya, Beth Drolet, Lanny Rosenwasser
DOI: 10.1016/j.jaci.2015.06.001
08/2015

Consensus communication on early peanut introduction and the prevention of peanut allergy in high-risk infants
World Allergy Organ J
David M. Fleischer, FOR THE LEAP TRIAL TEAM, Scott Sicherer, Matthew Greenhawt, Dianne Campbell, Edmond S. Chan, Antonella Muraro, Susanne Halken, Yitzhak Katz, Motohiro Ebisawa, Lawrence Eichenfield, Hugh Sampson, SECONDARY CONTRIBUTORS
DOI: 10.1186/s40413-015-0076-x
08/2015

Accidental exposures to peanut in a large cohort of Canadian children with peanut allergy
Clin Transl Allergy
Sabrine Cherkaoui, Moshe Ben-Shoshan, Reza Alizadehfar, Yuka Asai, Edmond Chan, Stephen Cheuk, Greg Shand, Yvan St-Pierre, Laurie Harada, Mary Allen, Ann Clarke
DOI: 10.1186/s13601-015-0055-x
04/2015

CSACI position statement: systemic effect of inhaled corticosteroids on adrenal suppression in the management of pediatric asthma
Allergy, Asthma & Clinical Immunology
Karine Issa-El-Khoury, Harold Kim, Edmond S Chan, Tim Vander Leek, Francisco Noya
DOI: 10.1186/s13223-015-0075-z
2015

Clinical Characteristics Of Seafood Allergy In Canadian Children
Journal of Allergy and Clinical Immunology
Victoria Cook, Edmond S. Chan, Ann Elaine Clarke, Greg Shand, Moshe Ben-Shoshan
DOI: 10.1016/j.jaci.2013.12.727
02/2014

Epinephrine auto injector administration by parents or patients for anaphylaxis during supervised oral food challenges and assessment of confidence
Allergy, Asthma & Clinical Immunology
Ingrid Baerg, Angela Alexander, Tiffany Wong, Timothy Teoh, Kyla Hildebrand, Sara Leo, Joanne Yeung, John Dean, Edmond Chan
DOI: 10.1186/1710-1492-10-s2-a2
2014

IgE-Mediated allergy to wheat in a child with celiac disease – a case report
Allergy, Asthma & Clinical Immunology
Tiffany Wong, Hin Ko, Edmond S Chan
DOI: 10.1186/1710-1492-10-56
2014

IgE Mediated allergy to wheat in a child with celiac disease
Allergy, Asthma & Clinical Immunology
Tiffany Wong, Edmond S Chan
DOI: 10.1186/1710-1492-10-s1-a37
2014

Dietary exposures and allergy prevention in high-risk infants: a joint position statement of the Canadian Society of Allergy and Clinical Immunology and the Canadian Paediatric Society
Allergy, Asthma & Clinical Immunology
Edmond S Chan, Carl Cummings, Adelle Atkinson, Zave Chad, Marie-Josée Francoeur, Linda Kirste, Douglas Mack, Marie-Noël Primeau, Timothy K Vander Leek, Wade TA Watson
DOI: 10.1186/1710-1492-10-45
2014

Delayed Introduction of Food and Effect On Incidence of Food Allergy in a Population At High Risk for Atopy: The Canadian Asthma Primary Prevention Study (CAPPS)
Journal of Allergy and Clinical Immunology
Tiffany Wong, Moira Chan-Yeung, Roxanne Rousseau, Anne Dybuncio, Anita L. Kozyrskyj, Clare Ramsey, Allan Becker, Edmond S. Chan
DOI: 10.1016/j.jaci.2012.12.1013
02/2013

Egg-allergic patients can be safely vaccinated against influenza
Journal of Allergy and Clinical Immunology
Anne Des Roches, Louis Paradis, Remi Gagnon, Chantal Lemire, Philippe Bégin, Stuart Carr, Edmond S. Chan, Jean Paradis, Lyne Frenette, Manale Ouakki, Mélanie Benoît, Gaston De Serres
DOI: 10.1016/j.jaci.2012.07.046
11/2012

Allergic symptoms after pandemic influenza vaccination rarely mediated by vaccine-specific IgE
Journal of Allergy and Clinical Immunology
Isabelle Rouleau, Gaston De Serres, Jean Philippe Drolet, Devi Banerjee, Chantal Lemire, Andrew Moore, Louis Paradis, Reza Alizadhefar, Anne Des Roches, Edmond S. Chan, Donald Stark, Mélanie Benoit, Danuta M. Skowronski
DOI: 10.1016/j.jaci.2012.07.019
2012

What are the beliefs of pediatricians and dietitians regarding complementary food introduction to prevent allergy?
Allergy, Asthma & Clinical Immunology
Sara Leo, John Dean, Edmond S Chan
DOI: 10.1186/1710-1492-8-3
2012

Outcome of diagnostic intervention predicts health-related quality of life scores among children with food allergy
Allergy, Asthma & Clinical Immunology
Linda Kirste, Tim K Takaro, Boris Kuzeljevic, Tiffany Wong, Edmond S Chan
DOI: 10.1186/1710-1492-8-s1-a9
2012

CSACI Position statement on the testing of food-specific IgG
Allergy, Asthma & Clinical Immunology
Stuart Carr, Edmond Chan, Elana Lavine, William Moote
DOI: 10.1186/1710-1492-8-12
2012

What are the beliefs of pediatricians and dietitians regarding complementary food introduction to prevent allergy?
Allergy, Asthma & Clinical Immunology
Sara H Leo, John M Dean, Edmond S Chan
DOI: 10.1186/1710-1492-7-s2-a3
2011

Serum sickness-like reaction associated with meropenem in a 3-year old child
Allergy, Asthma & Clinical Immunology
Sara H Leo, Edmond S Chan
DOI: 10.1186/1710-1492-6-s2-p31
2010

Safety of H1N1 and seasonal influenza vaccines in egg allergic patients in British Columbia
Allergy, Asthma & Clinical Immunology
Sara H Leo, John Dean, Edmond S Chan
DOI: 10.1186/1710-1492-6-s2-p4
2010

Epinephrine for the out-of-hospital (first-aid) treatment of anaphylaxis in infants: Is the ampule/syringe/needle method practical?
Journal of Allergy and Clinical Immunology
F.Estelle R. Simons, Edmond S. Chan, Xiaochen Gu, Keith J. Simons
DOI: 10.1067/mai.2001.119916
2001

Research

Epicutaneous Peanut Immunotherapy Clinical Trials
PEPITES, PEOPLE, REALISE, EPITOPE Clinical Trials

Early Peanut Introduction Implementation for Prevention of Peanut Allergy
Parent education via Public Health on early peanut introduction

Pre-school Peanut Oral Immunotherapy
Evaluation of real world safety outcomes for pre-school peanut oral immunotherapy

Grants

CIHR, Food allergy tolerance studies/Cow’s milk oral immunotherapy, $500,000, 11/2013 to 11/2018, Co-investigator

Honours & Awards

Clinical Faculty Award for Excellence in Clinical Teaching, UBC Faculty of Medicine - 2012

Family Centered Care Award, Partners in Care, BC Children's Hospital and BC Children's Hospital Foundation - 2012

UBC Department of Pediatrics, Ivory Tower Award, in recognition of contributions to promoting resident research and academic medicine - 2014

Research Group Members

Jordan Yeo
Victoria Cook, Allergy Fellow
Lianne Soller
Ingrid Baerg, Research Nurse
Kelly Morrison, Research Nurse
Tracy Gonzalez, Research Nurse
Linda Pringle, Research Nurse
Jonathan Bush, Pediatric and Perinatal Pathologist, BC Children's Hospital and BC Women's Hospital + Health Centre, Investigator, BC Children's Hospital
Jocelyn Jia
Elaine Wardley
Sharon To
Nicole Lee