Norbert Froese
MD, FRCPC
Investigator Emeritus, BC Children's Hospital
JMIR Perioperative Medicine
Sreepada, R.S. and Chang, A.C. and West, N.C. and Sujan, J. and Lai, B. and Poznikoff, A.K. and Munk, R. and Froese, N.R. and Chen, J.C. and Grges, M.
DOI: 10.2196/47398Seminars in Thoracic and Cardiovascular Surgery
Samuel, R. and Froese, N. and Betts, K. and Gandhi, S.
DOI: 10.1053/j.semtcvs.2020.06.038Journal of Thoracic and Cardiovascular Surgery
Harris, K.C. and Holowachuk, S. and Pitfield, S. and Sanatani, S. and Froese, N. and Potts, J.E. and Gandhi, S.K.
DOI: 10.1016/j.jtcvs.2014.06.093Anaesthesia and Intensive Care Medicine
Pitfield, A.F. and Froese, N.R.
DOI: 10.1016/j.mpaic.2014.09.009Annals of Thoracic Surgery
Hiebert, J.D. and Auld, B.C. and Sasaki, T. and Froese, N.R. and Ganshorn, M.K. and Casey, N.D. and Human, D.G. and Gandhi, S.K.
DOI: 10.1016/j.athoracsur.2012.12.054Journal of Clinical Monitoring and Computing
Chandler, J.R. and Cooke, E. and Petersen, C. and Karlen, W. and Froese, N. and Lim, J. and Ansermino, J.M.
DOI: 10.1007/s10877-012-9347-zPaediatrics and Child Health (Canada)
Gauvin, F. and Robillard, P. and Hume, H. and Grenier, D. and Whyte, R.K. and Webert, K.E. and Fergusson, D. and Lau, W. and Froese, N. and Delage, G.
DOI: 10.1093/pch/17.5.235Canadian Journal of Anesthesia
Froese, N. and McVicar, J. and Ansermino, M.
DOI: 10.1007/s12630-010-9399-9Pediatric Critical Care Medicine
Skippen, P. and Sanatani, S. and Froese, N. and Gow, R.M.
DOI: 10.1097/PCC.0b013e3181ae5b8aAnaesthesia and Intensive Care
Skippen, P.W. and Sanatani, S. and Gow, R.M. and Froese, N.
DOI: 10.1177/0310057x0903700506Pediatric Emergency Care
Levin, R. and Kissoon, N. and Froese, N.
DOI: 10.1097/PEC.0b013e3181aba8c1Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine
Froese, N.R. and Sett, S.S. and Mock, T. and Krahn, G.E.
Paediatrics and Child Health
Skippen, P. and Adderley, R. and Bennett, M. and Cogswell, A. and Froese, N. and Seear, M. and Wensley, D.
DOI: 10.1093/pch/13.6.502Journal of Clinical Monitoring and Computing
Tran, H. and Froese, N. and Dumont, G. and Lim, J. and Ansermino, J.M.
DOI: 10.1007/s10877-006-9051-yCanadian Journal of Anaesthesia
Froese, N. and Friesen, R.
DOI: 10.1007/BF03036977The assessment of intravascular volume status in children is a difficult task guided by minimal scientific evidence. Administration of intravenous fluid to hemodynamically unstable and anesthetised children is a common therapeutic intervention. Much evidence exists of the danger of indiscriminate intravenous fluid loading. Dynamic preload indicators have been demonstrated in adults to represent a good indicator of volume status, but little evidence exists in children.
We aim to compare the ability of static preload indicators (central venous pressure and pulmonary capillary wedge pressure) with less invasive dynamic indicators (pulse pressure variation, plethysmograph variation) to predict the cardiac output response to a fluid bolus. The ultimate aim of this study is to help improve the safety of fluid administration for sick children.
When a child undergoes heart surgery, a heart lung machine is used to keep blood flowing while the child’s own heart is stopped. After surgery, a significant amount of the child’s own blood is left in this machine. In the case of small children, the relative amount of blood potentially lost to the child in this way is very large.
In older children, and those who have undergone less complicated surgery, this blood can all returned to the child. Giving the child back his or her own blood makes is less likely that the child will need a transfusion of donated blood.
However, in younger children, or in children who have undergone more complicated surgery, most or all of this blood is thrown away. This is because of worry that returning this blood may cause bleeding, and excessive bleeding is one of the most feared complications of heart surgery.
This project will explore a method whereby the red blood cells left in the heart lung machine can be returned to children without increasing the risk of bleeding. It will also carefully examine the exact causes of higher bleeding risk in children getting their own blood back so that in the future, all children can have their own blood returned at the end of surgery.
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