Nassr Nama

MD, MSc, FRCPC, FAAP

Affiliate Investigator, BC Children's Hospital
Assistant Professor, Department of Pediatrics, Division of Hospital Medicine, Seattle Children's Hospital and University of Washington

My research interests are focused on improving care for hospitalized children. In particular, I aim to provide risk stratification tools that allow physicians to safely allocate precious clinical resources to high-risk patients.

Additionally, I have been interested in expediting evidence synthesis and shortening the process of implementing research findings in clinical practice. Along with a multi-disciplinary team from BC Children’s Hospital and CHEO (Ottawa, ON), I have launched a platform to crowdsource the systematic review process and provide an up-to-date living synthesis of evidence. This has allowed me to identify current knowledge gaps that will help to guide future research questions.

Academic Affiliations

  • Research Theme: Evidence to Innovation
  • Research Group(s): Clinical Practice, Outcomes and Innovation; Implementing Knowledge for Equity and System Change

Contact Information

Location

Seattle Children's Hospital, 4800 Sand Point Way NE, Seattle, Washington, United States of America (USA), 98105

Evaluation of Shared Decision-Making Interventions in Pediatric Acute Care: A Systematic Review

Hospital Pediatrics

Postill, G. and Buchanan, F. and Mahant, S. and Surees, A. and Hersi, L. and Cunningham, J. and Borkhoff, C.M. and Nama, N. and Gill, P.J.

DOI: 10.1542/hpeds.2024-008220

Acute Care Management of Brief Resolved Unexplained Events

Pediatric Emergency Care

Delaroche, A.M. and Nama, N. and Tieder, J.S.

DOI: 10.1097/PEC.0000000000003277

External Validation of Brief Resolved Unexplained Events Prediction Rules for Serious Underlying Diagnosis

JAMA Pediatrics

Nama, N. and Shen, Y. and Bone, J.N. and Lee, Z. and Picco, K. and Jin, F. and Foulds, J.L. and Gagnon, J.A. and Novak, C. and Parisien, B. and Donlan, M. and Goldman, R.D. and Sehgal, A. and Holland, J. and Mahant, S. and Tieder, J.S. and Gill, P.J.

DOI: 10.1001/jamapediatrics.2024.4399

Specialty Consultations and Diagnostic Testing Accuracy After Brief Resolved Unexplained Events: A Multicenter Observational Study

Hospital Pediatrics

Nama, N. and Rajasegaran, P.J. and McDaniel, L.M. and Donlan, M. and Quet, J. and Foulds, J.L. and Gagnon, J.A. and Novak, C. and Parisien, B. and Goldman, R.D. and Sehgal, A. and Kanani, R. and Holland, J. and Delaroche, A. and Mittal, M.K. and Stephans, A. and Mahant, S. and Coon, E.R. and Tieder, J.S. and Gill, P.J.

DOI: 10.1542/hpeds.2024-008305

Interhospital variation in the management of Brief Resolved Unexplained Events (BRUE) in infants: A Canadian multicenter cohort study

Journal of Hospital Medicine

Nama, N. and Picco, K. and Kyrychenko, P. and Bone, J.N. and Quet, J. and Foulds, J.L. and Gagnon, J.A. and Novak, C. and Parisien, B. and Donlan, M. and Goldman, R.D. and Sehgal, A. and Kanani, R. and Holland, J. and Mahant, S. and Coon, E. and Tieder, J.S. and Gill, P.J.

DOI: 10.1002/jhm.70094

Identifying serious underlying diagnoses among patients with brief resolved unexplained events (BRUEs): A Canadian cohort study

BMJ Paediatrics Open

Nama, N. and Lee, Z. and Picco, K. and Jin, F. and Bone, J.N. and Quet, J. and Foulds, J. and Gagnon, J.A. and Novak, C. and Parisien, B. and Donlan, M. and Goldman, R.D. and Sehgal, A. and Kanani, R. and Holland, J. and Kyrychenko, P. and Kirolos, N. and Opotchanova, I. and Harnois, ?. and Schacter, A. and Frizon-Peresa, E. and Rajasegaran, P. and Hosseini, P. and Wyslobicky, M. and Akbaroghli, S. and Nalan, P. and Mahant, S. and Tieder, J. and Gill, P.

DOI: 10.1136/bmjpo-2024-002525

Trends in the use and discussion of race in pediatrics articles over 75 years

Pediatrics

Nama, N. and Panda, P. and Montez, K. and Nafiu, O.O. and First, L.R. and Kemper, A.R.

DOI: 10.1542/peds.2023-064819

Challenges in Validation of Novel Diagnostic Tools for Pediatric Pneumonia: When Will We Find The One?

Hospital Pediatrics

Lambert-Fliszar, F. and Seaton, C. and Nama, N.

DOI: 10.1542/hpeds.2024-008040

Brief Resolved Unexplained Event: Evidence-Based and Family-Centered Management

Pediatrics in Review

Nama, N. and DeLaroche, A. and Bonkowsky, J.L. and Gremse, D. and Tieder, J.S.

DOI: 10.1542/pir.2024-006351

Epidemiology of brief resolved unexplained events and impact of clinical practice guidelines in general and pediatric emergency departments

Academic Emergency Medicine

Nama, N. and DeLaroche, A.M. and Neuman, M.I. and Mittal, M.K. and Herman, B.E. and Hochreiter, D. and Kaplan, R.L. and Stephans, A. and Tieder, J.S.

DOI: 10.1111/acem.14881

Conservative and Surgical Modalities in the Management of Pediatric Parapneumonic Effusion and Empyema: A Living Systematic Review and Network Meta-Analysis

Chest

Fernandez Elviro, C. and Longcroft-Harris, B. and Allin, E. and Leache, L. and Woo, K. and Bone, J.N. and Pawliuk, C. and Tarabishi, J. and Carwana, M. and Wright, M. and Nama, N. and Ananda, R.A. and Ramakrishnan, P. and Alhejazi, T.J. and Chen, A. and Sharifan, A. and Shawqi, M.M.

DOI: 10.1016/j.chest.2023.06.010

Short duration of parenteral antibiotics in infants with urinary tract infections

Paediatrics and Child Health (Canada)

Menon, N. and Mutinta Deasy, A. and Woo, K. and Tarabishi, J. and Chan, E.Y.-H. and Kang, K. and Carwana, M. and Nama, N.

DOI: 10.1093/pch/pxad030

Canadian infants presenting with Brief Resolved Unexplained Events (BRUEs) and validation of clinical prediction rules for risk stratification: A protocol for a multicentre, retrospective cohort study

BMJ Open

Nama, N. and Hosseini, P. and Lee, Z. and Picco, K. and Bone, J.N. and Foulds, J.L. and Gagnon, J.A. and Sehgal, A. and Quet, J. and Drouin, O. and Luu, T.M. and Vomiero, G. and Kanani, R. and Holland, J. and Goldman, R.D. and Kang, K.T. and Mahant, S. and Jin, F. and Tieder, J.S. and Gill, P.J.

DOI: 10.1136/bmjopen-2022-063183

Risk Prediction After a Brief Resolved Unexplained Event

Hospital Pediatrics

Nama, N. and Hall, M. and Neuman, M. and Sullivan, E. and Bochner, R. and De Laroche, A. and Hadvani, T. and Jain, S. and Katsogridakis, Y. and Kim, E. and Mittal, M. and Payson, A. and Prusakowski, M. and Shastri, N. and Stephans, A. and Westphal, K. and Wilkins, V. and Tieder, J.

DOI: 10.1542/hpeds.2022-006637

Duration of Antibiotic Therapy for the Management of Urinary Tract Infections in Newborns and Young Infants Aged Under 3 Months: A Living Systematic Review and Meta-analysis Using Crowdsourcing

Pediatrics

Brief Resolved Unexplained Event (BRUE): Is Reassurance Enough for Caregivers?

Hospital Pediatrics

Nama, N. and DeLaroche, A.M. and Gremse, D.A.

DOI: 10.1542/hpeds.2022-006939

Successful incorporation of single reviewer assessments during systematic review screening: development and validation of sensitivity and work-saved of an algorithm that considers exclusion criteria and count

Systematic Reviews

Nama, N. and Hennawy, M. and Barrowman, N. and O?Hearn, K. and Sampson, M. and McNally, J.D.

DOI: 10.1186/s13643-021-01632-6

Evaluating the relationship between citation set size, team size and screening methods used in systematic reviews: a cross-sectional study

BMC Medical Research Methodology

O?Hearn, K. and MacDonald, C. and Tsampalieros, A. and Kadota, L. and Sandarage, R. and Jayawarden, S.K. and Datko, M. and Reynolds, J.M. and Bui, T. and Sultan, S. and Sampson, M. and Pratt, M. and Barrowman, N. and Nama, N. and Page, M. and McNally, J.D.

DOI: 10.1186/s12874-021-01335-5

Conservative and surgical modalities in the management of paediatric parapneumonic effusion and empyema: A protocol for a living systematic review and network meta-Analysis

BMJ Open

Allin, E. and Nama, N. and Irvine, M.A. and Pawliuk, C. and Wright, M. and Carwana, M.

DOI: 10.1136/bmjopen-2020-045010

Creating enriched training sets of eligible studies for large systematic reviews: the utility of PubMeds Best Match algorithm

International Journal of Technology Assessment in Health Care

Sampson, M. and Nama, N. and O?Hearn, K. and Murto, K. and Nasr, A. and Katz, S.L. and Macartney, G. and Momoli, F. and McNally, J.D.

DOI: 10.1017/S0266462320002159

Treatment of UTIs in infants <2 months: A living systematic review

Hospital Pediatrics

Nama, N. and Donken, R. and Pawliuk, C. and Leache, L. and Sadarangani, M. and Carwana, M. and Rizakos, S. and Sheng, A. and Cummings, H. and Dhillon, D. and Hsu, B.E. and Gawish, H. and Oganesyan, A. and O'Mahony, A. and Abdulazeem, H. and Sandarage, R. and Hosseini, P. and Xu, C. and Reisi-Vanani, V. and Jayawarden, S.K. and Nguyen, L. and Saeidiborojeni, S. and Khondker, A. and Fathalla, Z. and Wang, J. and Kipfer, S. and O'Hearn, K. and McNally, J.D.

DOI: 10.1542/hpeds.2021-005877

Live Scoping Review of N95 and Surgical Facemask Decontamination and Reuse: A Scoping Review Protocol

Katie O'Hearn and Anirudh Agarwal and Karen Choong and Shira Gertsman and Nassr Nama and Margaret Sampson and Lindsey Sikora and David J Zorko and James Dayre McNally

DOI: 10.31219/osf.io/rpc27

05 / 2020

Vincristine-induced peripheral neurotoxicity: A prospective cohort

Pediatric Hematology and Oncology

Nama, N. and Barker, M.K. and Kwan, C. and Sabarre, C. and Solimano, V. and Rankin, A. and Raabe, J. and Ross, C.J. and Carleton, B. and Zwicker, J.G. and Rassekh, S.R.

DOI: 10.1080/08880018.2019.1677832

Quality control for crowdsourcing citation screening: the importance of assessment number and qualification set size

Journal of Clinical Epidemiology

Nama, N. and Barrowman, N. and O'Hearn, K. and Sampson, M. and Zemek, R. and McNally, J.D.

DOI: 10.1016/j.jclinepi.2020.02.009

Identification and Evaluation of Controlled Trials in Pediatric Cardiology: Crowdsourced Scoping Review and Creation of Accessible Searchable Database

Canadian Journal of Cardiology

Ashkanase, J. and Nama, N. and Sandarage, R.V. and Penslar, J. and Gupta, R. and Ly, S. and Wan, M. and Tsang, P. and Nantsios, A. and Jacques, E. and Yang, H.Y. and Tsang, C.I. and Mazhar, H. and Xu, G. and Rodriguez, M. and Gerber, S. and Laird, L.M. and Sampson, M. and Wong, D.T. and McNally, J.D.

DOI: 10.1016/j.cjca.2020.01.028

Crowdsourcing the citation screening process for systematic reviews: Validation study

Journal of Medical Internet Research

Nama, N. and Sampson, M. and Barrowman, N. and Sandarage, R. and Menon, K. and Macartney, G. and Murto, K. and Vaccani, J.-P. and Katz, S. and Zemek, R. and Nasr, A. and McNally, J.D.

DOI: 10.2196/12953

LGBT Patients and Families Health Issues: Medical Students' Attitudes and the Inclusivity of Medical School

Pediatrics

DOI: 10.1542/PEDS.142.1_MEETINGABSTRACT.791

Ligand-specific conformational transitions and intracellular transport are required for atypical chemokine receptor 3-mediated chemokine scavenging

Journal of Biological Chemistry

DOI: 10.1074/JBC.M117.814947

Vitamin D deficiency in critically ill children: A systematic review and meta-analysis

Critical Care

McNally, J.D. and Nama, N. and O'Hearn, K. and Sampson, M. and Amrein, K. and Iliriani, K. and McIntyre, L. and Fergusson, D. and Menon, K.

DOI: 10.1186/s13054-017-1875-y

A pilot validation study of crowdsourcing systematic reviews: Update of a searchable database of pediatric clinical trials of highdose Vitamin D

Translational Pediatrics

Nama, N. and Iliriani, K. and Xia, M.Y. and Chen, B.P. and Zhou, L.L. and Pojsupap, S. and Kappel, C. and O'Hearn, K. and Sampson, M. and Menon, K. and McNally, J.D.

DOI: 10.21037/tp.2016.12.01

Medical students' perception of lesbian, gay, bisexual, and transgender (LGBT) discrimination in their learning environment and their self-reported comfort level for caring for LGBT patients: A survey study

Medical Education Online

Nama, N. and MacPherson, P. and Sampson, M. and McMillan, H.J.

DOI: 10.1080/10872981.2017.1368850

A systematic review of pediatric clinical trials of high dose vitamin D

PeerJ

Nama, N. and Menon, K. and Iliriani, K. and Pojsupap, S. and Sampson, M. and O'Hearn, K. and Zhou, L. and McIntyre, L. and Fergusson, D. and McNally, J.D.

DOI: 10.7717/peerj.1701

THE PEPTIDOMIMETIC TC14012, AN INVERSE AGONIST ON CXCR4-beta-ARRESTIN2 PATHWAY

Journal of Receptors and Signal Transduction

Brief Resolved Unexplained Events (BRUEs)

Along with an international collaboration, I am completing a project to identify infants with a serious diagnosis among those presenting with a BRUE. The derived algorithm will be implemented in a multicenter quality improvement project across North America.

Urinary Tract Infections (UTIs)

Our team has recently completed a systematic review on the effective duration of treatment for neonates with urinary tract infections. I am currently collaborating locally with members of the Division of General Pediatrics and Infectious Disease to shorten the length of hospital stay and treatment duration for these patients as a quality improvement.

Crowdsourcing Systematic Reviews

Using an innovative crowdsourcing approach, our team has been able to accelerate the process of evidence synthesis, leading to the completion of systematic reviews within a short period of time. To date, we have completed several systematic reviews targeting the treatment of UTIs, the treatment of pneumonia, the role of high-dose vitamin D, and a database of all available pediatric cardiac RCTs. As an example, we completed the systematic review on UTI treatment with a crowd from 13 different countries, and spanning 5 different continents. The crowd was able to screen more than 10,000 publications within 2-3 weeks.

Grants

2021 – American Academy of Pediatrics Resident Research Grant – Derivation and Validation of a Clinical Prediction Rule to Determine Risk in Infants experiencing a Brief Resolved Unexplained Events (BRUEs). Nama N, Tieder JS

2021 – Resident Doctors of BC Innovation Fund – Treatment of urinary tract infections in infants under 3 months of age: A living meta-analysis. Nama N, Donken R, Sadarangani M, and Carwana M

2020 – BC Children’s Hospital Resident Research Grant – Treatment of urinary tract infections in infants under 3 months of age: A living meta-analysis. Nama N, Carwana M

2019 – BC Children’s Hospital Resident Research Grant – Peripheral Neuropathy with Vincristine: A Prospective Cohort. Nama N, Rassekh SR

2016 – CHEO Research Growth Award – Crowdsourcing Systematic Reviews: A Proof of Concept Validation Study. McNally JD, Nama N, Sampson M, Momoli F, Barrowman N, Menon K, Nasr A, Macartney G, Murto K, Vaccani J-P, Zemek R, Henderson M

Honours & Awards

2021 – Friedman Award for Scholars in Health – Infants most at risk for a serious diagnosis explaining a brief resolved unexplained event. Nama N, Tieder JS

2021 – University of British Columbia – UGME Resident/Fellow Teaching Award

Our Research

At BC Children’s, we are making discoveries that save lives and transform health care for children in our province and around the world. Our research portfolio includes basic, clinical, population, and public health research.

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