- Overview
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Chronic kidney disease (CKD) is a significant and growing public health problem. It is currently estimated that 13% of the adult population has CKD and it confers a 5-fold increased risk of premature cardiovascular disease and death. Those who survive long enough eventually require renal replacement therapy with dialysis or a kidney transplant. Many of the risk factors for CKD begin in childhood. a patient develops CKD, the pathological changes that worsen dysfunction are similar in all kidney diseases, and are characterized by a process of ongoing scarring or fibrosis. Despite tremendous progress in our understanding of the causes and consequences of CKD, effective therapies are unknown. Using experimental models of CKD, our studies are designed to investigate how specific cells and molecules mediate kidney fibrosis, with the ultimate goal of translating our findings into new human therapies.
- Publications
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Child and caregiver perspectives on access to psychosocial and educational support in pediatric chronic kidney disease: a focus group study
Pediatric Nephrology
Zhang, Y. and Gutman, T. and Tong, A. and Craig, J.C. and Sinha, A. and Dart, A. and Eddy, A.A. and Gipson, D.S. and Bockenhauer, D. and Yap, H.-K. and Groothoff, J. and Zappitelli, M. and J.A.Webb, N. and Alexander, S.I. and Furth, S. and Samuel, S. and Blydt-Hansen, T.D. and Dionne, J. and Michael, M. and Wenderfer, S.E. and Winkelmayer, W.C. and McTaggart, S. and Walker, A. and Zimmerman, C.T. and Ralph, A.F. and Ju, A. and James, L.J. and Hanson, C.S.
DOI: 10.1007/s00467-022-05551-z
2023Lessons learned from regional training of paediatric nephrology fellows in Africa
Pediatric Nephrology
DOI: 10.1007/s00467-023-06022-9
2023Perspectives of Clinicians on Shared Decision Making in Pediatric CKD: A Qualitative Study
American Journal of Kidney Diseases
Kerklaan, J. and Hanson, C.S. and Carter, S. and Tong, A. and Sinha, A. and Dart, A. and Eddy, A.A. and Guha, C. and Gipson, D.S. and Bockenhauer, D. and Hannan, E. and Yap, H.-K. and Groothoff, J. and Zappitelli, M. and Amir, N. and Alexander, S.I. and Furth, S.L. and Samuel, S. and Gutman, T. and Craig, J.C.
DOI: 10.1053/j.ajkd.2021.12.009
2022Impact of training nephrologists from developing nations and strategies for sustaining a training program in its fourth decade.
Kidney international
Okpechi IG and Eddy AA and Jha V and Jacob T and Dupuis S and Harris DC
DOI: 10.1016/j.kint.2021.02.029
PubMed: 33711332
03/2021Patient and caregiver perspectives on blood pressure in children with chronic kidney disease
Nephrology Dialysis Transplantation
Wu, J.G.-A. and Tong, A. and Evangelidis, N. and Manera, K.E. and Hanson, C.S. and Baumgart, A. and Amir, N. and Sinha, A. and Dart, A. and Eddy, A.A. and Guha, C. and Gipson, D.S. and Bockenhauer, D. and Yap, H.-K. and Groothoff, J. and Zappitelli, M. and Alexander, S.I. and Furth, S.L. and Samuel, S. and Carter, S.A. and Walker, A. and Kausman, J. and Martinez-Martin, D. and Gutman, T. and Craig, J.C.
DOI: 10.1093/ndt/gfab194
2021Developing Consensus-Based Outcome Domains for Trials in Children and Adolescents With CKD: An International Delphi Survey.
American journal of kidney diseases : the official journal of the National Kidney Foundation
Logeman C and Guha C and Howell M and Hanson CS and Craig JC and Samuel S and Zappitelli M and Matsuda-Abedini M and Dart A and Furth S and Eddy A and Groothoff J and Yap HK and Tong A
DOI: 10.1053/j.ajkd.2020.03.014
PubMed: 32654889
07/2020Establishing core outcome domains in pediatric kidney disease: report of the Standardized Outcomes in Nephrology-Children and Adolescents (SONG-KIDS) consensus workshops.
Kidney international
Hanson CS and Craig JC and Logeman C and Sinha A and Dart A and Eddy AA and Guha C and Gipson DS and Bockenhauer D and Yap HK and Groothoff J and Zappitelli M and Webb NJA and SONG-Kids consensus workshops investigators
DOI: 10.1016/j.kint.2020.05.054
PubMed: 32628942
07/2020Drug-induced tubulointerstitial nephritis: hypersensitivity and necroinflammatory pathways
Pediatric Nephrology
Eddy, A.A.
DOI: 10.1007/s00467-019-04207-9
2020The Canadian childhood nephrotic syndrome (CHILDNEPH) study: report on mid-study feasibility, recruitment and main measures.
BMC nephrology
Samuel SM and Dart A and Filler G and Bitzan M and Pinsk M and Mammen C and Nettel-Aguirre A and Perinpanayagam MA and Takano T and Chanchlani R and Zappitelli M and other members of the Canadian Childhood Nephrotic Syndrome Project Team
DOI: 10.1186/s12882-019-1320-3
PubMed: 31088399
05/2019Global Health Training Opportunities in North American Nephrology Fellowships.
Kidney international reports
Rope R and Perl J and Anand S and International Society of Nephrology North American and Caribbean Regional Board
DOI: 10.1016/j.ekir.2019.04.019
PubMed: 31384697
05/2019Identifying Important Outcomes for Young People With CKD and Their Caregivers: A Nominal Group Technique Study.
American journal of kidney diseases : the official journal of the National Kidney Foundation
Hanson CS and Gutman T and Craig JC and Bernays S and Raman G and Zhang Y and James LJ and Ralph AF and Ju A and Manera KE and Teixeira-Pinto A and Viecelli AK and Alexander SI and Tong A
DOI: 10.1053/j.ajkd.2018.12.040
PubMed: 30885704
03/2019Implementing core outcomes in kidney disease: report of the Standardized Outcomes in Nephrology (SONG) implementation workshop.
Kidney international
Tong A and Manns B and Wang AYM and Hemmelgarn B and Wheeler DC and Gill J and Tugwell P and Pecoits-Filho R and Crowe S and Harris T and Van Biesen W and Winkelmayer WC and Levin A and SONG Implementation Workshop Investigators
DOI: 10.1016/j.kint.2018.08.018
PubMed: 30360959
10/2018Child and Parental Perspectives on Communication and Decision Making in Pediatric CKD: A Focus Group Study.
American journal of kidney diseases : the official journal of the National Kidney Foundation
Gutman T and Hanson CS and Bernays S and Craig JC and Sinha A and Dart A and Eddy AA and Gipson DS and Bockenhauer D and Yap HK and Groothoff J and Zappitelli M and Webb NJA and Tong A
DOI: 10.1053/j.ajkd.2018.05.005
PubMed: 29980375
07/2018Does specialist physician supply affect pediatric asthma health outcomes?
BMC health services research
Filler G and Kovesi T and Bourdon E and Jones SA and Givelichian L and Rockman-Greenberg C and Gilliland J and Williams M and Orrbine E and Piedboeuf B and Paediatric Chairs of Canada Mark Bernstein
DOI: 10.1186/s12913-018-3084-z
PubMed: 29622002
04/2018Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy
Physiological Reports
Maydan, O. and McDade, P.G. and Liu, Y. and Wu, X.-R. and Matsell, D.G. and Eddy, A.A.
DOI: 10.14814/phy2.13654
2018Range and Heterogeneity of Outcomes in Randomized Trials of Pediatric Chronic Kidney Disease
Journal of Pediatrics
Chong, L.S.H. and Sautenet, B. and Tong, A. and Hanson, C.S. and Samuel, S. and Zappitelli, M. and Dart, A. and Furth, S. and Eddy, A.A. and Groothoff, J. and Webb, N.J.A. and Yap, H.-K. and Bockenhauer, D. and Sinha, A. and Alexander, S.I. and Goldstein, S.L. and Gipson, D.S. and Raman, G. and Craig, J.C.
DOI: 10.1016/j.jpeds.2017.03.034
2017Interstitial nephritis in children
Pediatric Kidney Disease: Second Edition
Verghese, P.S. and Luckritz, K.E. and Eddy, A.A.
DOI: 10.1007/978-3-662-52972-0_38
2017Standardised Outcomes in Nephrology-Children and Adolescents (SONG-Kids): A protocol for establishing a core outcome set for children with chronic kidney disease
Trials
Tong, A. and Samuel, S. and Zappitelli, M. and Dart, A. and Furth, S. and Eddy, A. and Groothoff, J. and Webb, N.J.A. and Yap, H.-K. and Bockenhauer, D. and Sinha, A. and Alexander, S.I. and Goldstein, S.L. and Gipson, D.S. and Hanson, C.S. and Evangelidis, N. and Crowe, S. and Harris, T. and Hemmelgarn, B.R. and Manns, B. and Gill, J. and Tugwell, P. and Van Biesen, W. and Wheeler, D.C. and Winkelmayer, W.C. and Craig, J.C.
DOI: 10.1186/s13063-016-1528-5
2016The impact of small kidneys
Pediatric Nephrology
Matsell, D.G. and Cojocaru, D. and Matsell, E.W. and Eddy, A.A.
DOI: 10.1007/s00467-015-3079-5
2015Cysteamine modulates oxidative stress and blocks myofibroblast activity in CKD
Journal of the American Society of Nephrology
Okamura, D.M. and Bahrami, N.M. and Ren, S. and Pasichnyk, K. and Williams, J.M. and Gangoiti, J.A. and Lopez-Guisa, J.M. and Yamaguchi, I. and Barshop, B.A. and Duffield, J.S. and Eddy, A.A.
DOI: 10.1681/ASN.2012090962
2014Overview of the cellular and molecular basis of kidney fibrosis
Kidney International Supplements
Eddy, A.A.
DOI: 10.1038/kisup.2014.2
2014The Canadian Childhood Nephrotic Syndrome (CHILDNEPH) project: Overview of design and methods
Canadian Journal of Kidney Health and Disease
Samuel, S. and Scott, S. and Morgan, C. and Dart, A. and Mammen, C. and Parekh, R. and Nettel-Aguirre, A. and Eddy, A. and Flynn, R. and Pinsk, M. and Wade, A. and Arora, S. and Benoit, G. and Bitzan, M. and Erickson, R. and Feber, J. and Filler, G. and Geier, P. and Girardin, C. and Grisaru, S. and Tee, J. and Kemp, K. and Zappitelli, M.
DOI: 10.1186/2054-3581-1-17
2014Social paediatrics: From 'lip service' to the health and well-being of Canada's children and youth.
Daneman D and Kellner J and Bernstein M and Dow K and Dugas MA and Duffy C and Eddy A and Filler G and Frappier JY and Gilmour S and Givelichian L and Huang L and Rockman-Greenberg C and Shevell M and Vardy C and Walti H and Orrbine E and Williams M
PubMed: 24421706
08/2013Rising part-time work in the academic pediatric workforce in Canada.
Filler G and Givelichian L and Walti H and Piedboeuf B and Pediatric Chairs of Canada
DOI: 10.1016/j.jpeds.2013.04.040
PubMed: 23885849
08/2013Acute kidney injury and its association with in-hospital mortality among children with acute infections
Pediatric Nephrology
Imani, P.D. and Odiit, A. and Hingorani, S.R. and Weiss, N.S. and Eddy, A.A.
DOI: 10.1007/s00467-013-2544-2
2013The origin of scar-forming kidney myofibroblasts
Nature Medicine
Eddy, A.A.
DOI: 10.1038/nm.3299
2013Social paediatrics: From 'lip service' to the health and well-being of Canada's children and youth
Paediatrics and Child Health (Canada)
Daneman, D. and Kellner, J. and Bernstein, M. and Dow, K. and Dugas, M.A. and Duffy, C. and Eddy, A. and Filler, G. and Frappier, J.-Y. and Gilmour, S. and Givelichian, L. and Huang, L. and Rockman-Greenberg, C. and Shevell, M. and Vardy, C. and Walti, H. and Orrbine, E. and Williams, M.
2013Mannose Receptor 2 Attenuates Renal Fibrosis
Journal of the American Society of Nephrology
DOI: 10.1681/asn.2011030310
02/2012Critical and honest conversations: The evidence behind the "choosing Wisely" campaign recommendations by the American society of nephrology
Clinical Journal of the American Society of Nephrology
Williams, A.W. and Dwyer, A.C. and Eddy, A.A. and Fink, J.C. and Jaber, B.L. and Linas, S.L. and Michael, B. and O'Hare, A.M. and Schaefer, H.M. and Shaffer, R.N. and Trachtman, H. and Weiner, D.E. and Falk, R.J.
DOI: 10.2215/CJN.04970512
2012Investigating mechanisms of chronic kidney disease in mouse models
Pediatric Nephrology
Eddy, A.A. and López-Guisa, J.M. and Okamura, D.M. and Yamaguchi, I.
DOI: 10.1007/s00467-011-1938-2
2012Albumin-induced apoptosis of glomerular parietal epithelial cells is modulated by extracellular signal-regulated kinase 1/2
Nephrology Dialysis Transplantation
Chang, A.M. and Ohse, T. and Krofft, R.D. and Wu, J.S. and Eddy, A.A. and Pippin, J.W. and Shankland, S.J.
DOI: 10.1093/ndt/gfr483
2012Vascular endothelial cadherin modulates renal interstitial fibrosis
Nephron - Experimental Nephrology
Yamaguchi, I. and Tchao, B.N. and Burger, M.L. and Yamada, M. and Hyodo, T. and Giampietro, C. and Eddy, A.A.
DOI: 10.1159/000332026
2012Nicotinic acetylcholine receptor a1 promotes calpain-1 activation and macrophage inflammation in hypercholesterolemic nephropathy
Laboratory Investigation
Zhang, G. and Thomas, A.L. and Marshall, A.L. and Kernan, K.A. and Su, Y. and Zheng, Y. and Takano, J. and Saido, T.C. and Eddy, A.A.
DOI: 10.1038/labinvest.2010.135
2011The TGF-ß route to renal fibrosis is not linear: The miR-21 viaduct
Journal of the American Society of Nephrology
Eddy, A.A.
DOI: 10.1681/ASN.2011070698
2011Scraping fibrosis: UMODulating renal fibrosis
Nature Medicine
Eddy, A.A.
DOI: 10.1038/nm0511-553
2011Galectin-3 preserves renal tubules and modulates extracellular matrix remodeling in progressive fibrosis
American Journal of Physiology - Renal Physiology
Okamura, D.M. and Pasichnyk, K. and Lopez-Guisa, J.M. and Collins, S. and Hsu, D.K. and Liu, F.-T. and Eddy, A.A.
DOI: 10.1152/ajprenal.00326.2010
2011Vitronectin accumulates in the interstitium but minimally impacts fibrogenesis in experimental chronic kidney disease
American Journal of Physiology - Renal Physiology
López-Guisa, J.M. and Rassa, A.C. and Cai, X. and Collins, S.J. and Eddy, A.A.
DOI: 10.1152/ajprenal.00701.2010
2011Systemic Lupus Erythematosus
Textbook of Pediatric Rheumatology
Silverman, E. and Eddy, A.
DOI: 10.1016/B978-1-4160-6581-4.10021-4
2011Phase 1 Trial of Adalimumab in Focal Segmental Glomerulosclerosis (FSGS): II. Report of the FONT (Novel Therapies for Resistant FSGS) Study Group
American Journal of Kidney Diseases
Joy, M.S. and Gipson, D.S. and Powell, L. and MacHardy, J. and Jennette, J.C. and Vento, S. and Pan, C. and Savin, V. and Eddy, A. and Fogo, A.B. and Kopp, J.B. and Cattran, D. and Trachtman, H.
DOI: 10.1053/j.ajkd.2009.08.019
2010Round 3 at JASN (2001 to 2007): Recollections of the third editorial team
Journal of the American Society of Nephrology
Couser, W. and Eddy, A.A. and Hill, C.
DOI: 10.1681/ASN.2009101074
2010Serine proteases, inhibitors and receptors in renal fibrosis.
Eddy AA
PubMed: 19350108
04/2009CD36 regulates oxidative stress and inflammation in hypercholesterolemic CKD
Journal of the American Society of Nephrology
Okamura, D.M. and Pennathur, S. and Pasichnyk, K. and López-Guisa, J.M. and Collins, S. and Febbraio, M. and Heinecke, J. and Eddy, A.A.
DOI: 10.1681/ASN.2008010009
2009Phase I trial of rosiglitazone in FSGS: I. Report of the font study group
Clinical Journal of the American Society of Nephrology
Joy, M.S. and Gipson, D.S. and Dike, M. and Powell, L. and Thompson, A. and Vento, S. and Eddy, A. and Fogo, A.B. and Kopp, J.B. and Cattran, D. and Trachtman, H.
DOI: 10.2215/CJN.02310508
2009Serine proteases, inhibitors and receptors in renal fibrosis
Thrombosis and Haemostasis
Eddy, A.A.
DOI: 10.1160/TH08-12-0779
2009A novel signaling pathway: Fibroblast nicotinic receptor a1 binds urokinase and promotes renal fibrosis
Journal of Biological Chemistry
Zhang, G. and Kernan, K.A. and Thomas, A. and Collins, S. and Song, Y. and Li, L. and Zhu, W. and LeBoeuf, R.C. and Eddy, A.A.
DOI: 10.1074/jbc.M109.010249
2009Interstitial Nephritis
Comprehensive Pediatric Nephrology
Verghese, P.S. and Luckritz, K.E. and Eddy, A.A.
DOI: 10.1016/B978-0-323-04883-5.50040-4
2008Macrophage diversity in renal injury and repair
Journal of Clinical Investigation
Ricardo, S.D. and Van Goor, H. and Eddy, A.A.
DOI: 10.1172/JCI36150
2008Angiotensin converting enzyme inhibitor but not angiotensin receptor blockade or statin ameliorates murine adriamycin nephropathy
Kidney International
Tang, S.C.W. and Leung, J.C.K. and Chan, L.Y.Y. and Eddy, A.A. and Lai, K.N.
DOI: 10.1038/sj.ki.5002674
2008Urokinase and its receptors in chronic kidney disease
Frontiers in Bioscience
Zhang, G. and Eddy, A.A.
DOI: 10.2741/3093
2008Endogenous urokinase lacks antifibrotic activity during progressive renal injury
American Journal of Physiology - Renal Physiology
Yamaguchi, I. and Lopez-Guisa, J.M. and Cai, X. and Collins, S.J. and Okamura, D.M. and Eddy, A.A.
DOI: 10.1152/ajprenal.00380.2006
2007Atherogenic scavenger receptor modulation in the tubulointerstitium in response to chronic renal injury
American Journal of Physiology - Renal Physiology
Okamura, D.M. and López-Guisa, J.M. and Koelsch, K. and Collins, S. and Eddy, A.A.
DOI: 10.1152/ajprenal.00063.2007
2007Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: Role of plasmin-activated signals
Journal of the American Society of Nephrology
Zhang, G. and Kernan, K.A. and Collins, S.J. and Cai, X. and López-Guisa, J.M. and Degen, J.L. and Shvil, Y. and Eddy, A.A.
DOI: 10.1681/ASN.2006080886
2007JASN moves on
Journal of the American Society of Nephrology
Couser, W.G. and Hill, C. and Eddy, A.A.
DOI: 10.1681/ASN.2007040415
2007Plasminogen activator inhibitor-1 deficiency has renal benefits but some adverse systemic consequences in diabetic mice.
Collins SJ and Alexander SL and Lopez-Guisa JM and Cai X and Maruvada R and Chua SC and Zhang G and Okamura DM and Matsuo S and Eddy AA
PubMed: 16735799
2006Plasminogen activator inhibitor-1 in chronic kidney disease: Evidence and mechanisms of action
Journal of the American Society of Nephrology
Eddy, A.A. and Fogo, A.B.
DOI: 10.1681/ASN.2006050503
2006Subepithelial humps and microthrombi: Looking for a mechanism
American Journal of Kidney Diseases
Simon, D. and Finn, L. and Eddy, A.
DOI: 10.1053/j.ajkd.2005.07.052
2006Plasminogen activator inhibitor-1 deficiency has renal benefits but some adverse systemic consequences in diabetic mice
Nephron - Experimental Nephrology
Collins, S.J. and Alexander, S.L. and Lopez-Guisa, J.M. and Cai, X. and Maruvada, R. and Chua, S.C. and Zhang, G. and Okamura, D.M. and Matsuo, S. and Eddy, A.A.
DOI: 10.1159/000093673
2006Chronic kidney disease progression
Journal of the American Society of Nephrology
Eddy, A.A. and Neilson, E.G.
DOI: 10.1681/ASN.2006070704
2006Ramping up endogenous defences against chronic kidney disease
Nephrology Dialysis Transplantation
Eddy, A.A.
DOI: 10.1093/ndt/gfl102
2006Progression in chronic kidney disease
Advances in Chronic Kidney Disease
Eddy, A.A.
DOI: 10.1053/j.ackd.2005.07.011
2005Multifunctionality of PAI-1 in fibrogenesis: Evidence from obstructive nephropathy in PAI-1-overexpressing mice
Kidney International
Matsuo, S. and López-Guisa, J.M. and Cai, X. and Okamura, D.M. and Alpers, C.E. and Bumgarner, R.E. and Peters, M.A. and Zhang, G. and Eddy, A.A.
DOI: 10.1111/j.1523-1755.2005.00327.x
2005Can renal fibrosis be reversed?
Pediatric Nephrology
Eddy, A.A.
DOI: 10.1007/s00467-005-1995-5
2005Erratum: Multifunctionality of PAI-1 in fibrogenesis: Evidence from obstructive nephropathy in PAI-1-overexpressing mice (Kidney International (2005) 67 (2221-2238))
Kidney International
Matsuo, S. and López-Guisa, J.M. and Cai, X. and Okamura, D.M. and Alpers, C.E. and Bumgarner, R.E. and Peters, M.A. and Zhang, G. and Eddy, A.A.
DOI: 10.1111/j.1523-1755.2005.90682.x
2005Why is proteinuria an ominous biomarker of progressive kidney disease?
Kidney International, Supplement
Zandi-Nejad, K. and Eddy, A.A. and Glassock, R.J. and Brenner, B.M.
DOI: 10.1111/j.1523-1755.2004.09220.x
PubMed: 15485426
2004Mitogenic signaling of urokinase receptor-deficient kidney fibroblasts: Actions of an alternative urokinase receptor and LDL receptor-related protein
Journal of the American Society of Nephrology
Zhang, G. and Cai, X. and López-Guisa, J.M. and Collins, S.J. and Eddy, A.A.
DOI: 10.1097/01.ASN.0000135057.41526.2C
2004Expression of nephrin in acquired forms of nephrotic syndrome in childhood
Pediatric Nephrology
Hingorani, S.R. and Finn, L.S. and Kowalewska, J. and McDonald, R.A. and Eddy, A.A.
DOI: 10.1007/s00467-003-1346-3
2004Exogenous bone morphogenetic protein-7 fails to attenuate renal fibrosis in rats with overload proteinuria
Nephron - Experimental Nephrology
Ikeda, Y. and Jung, Y.O. and Kim, H. and Oda, T. and López-Guisa, J. and Maruvada, R. and Diamond, D.L. and Martin, K.J. and Wing, D. and Cai, X. and Eddy, A.A.
DOI: 10.1159/000079177
2004The NPHP1 gene deletion associated with juvenile nephronophthisis is present in a subset of individuals with Joubert syndrome
American Journal of Human Genetics
Parisi, M.A. and Bennett, C.L. and Eckert, M.L. and Dobyns, W.B. and Gleeson, J.G. and Shaw, D.W.W. and McDonald, R. and Eddy, A. and Chance, P.F. and Glass, I.A.
DOI: 10.1086/421846
2004Proteinuria and interstitial injury
Nephrology Dialysis Transplantation
Eddy, A.A.
DOI: 10.1093/ndt/gfg533
2004Urokinase receptor deficiency accelerates renal fibrosis in obstructive nephropathy
Journal of the American Society of Nephrology
Zhang, G. and Kim, H. and Cai, X. and López-Guisa, J.M. and Alpers, C.E. and Liu, Y. and Carmeliet, P. and Eddy, A.A.
DOI: 10.1097/01.ASN.0000064292.37793.FB
2003Urokinase receptor modulates cellular and angiogenic responses in obstructive nephropathy
Journal of the American Society of Nephrology
Zhang, G. and Kim, H. and Cai, X. and Lopez-Guisa, J.M. and Carmeliet, P. and Eddy, A.A.
DOI: 10.1097/01.ASN.0000064701.70231.3F
2003Nephrotic syndrome in childhood
Lancet
Eddy, A.A. and Symons, J.M.
DOI: 10.1016/S0140-6736(03)14184-0
2003Longterm followup of childhood lupus nephritis.
Hagelberg S and Lee Y and Bargman J and Mah G and Schneider R and Laskin C and Eddy A and Gladman D and Urowitz M and Hebert D and Silverman E
PubMed: 12465165
12/2002Plasminogen activator inhibitor-1 and the kidney.
Eddy AA
PubMed: 12110504
08/2002An introduction to Frontiers in Nephrology
Journal of the American Society of Nephrology
Eddy, A.A. and Couser, W.G.
DOI: 10.1097/01.ASN.0000026725.09795.90
2002Plasminogen activator inhibitor-1 and the kidney
American Journal of Physiology - Renal Physiology
Eddy, A.A.
DOI: 10.1152/ajprenal.00032.2002
2002And we're off!
Journal of the American Society of Nephrology
Couser, W.G. and Eddy, A.
2002Longterm followup of childhood lupus nephritis
Journal of Rheumatology
Hagelberg, S. and Lee, Y. and Bargman, J. and Mah, G. and Schneider, R. and Laskin, C. and Eddy, A. and Gladman, D. and Urowitz, M. and Hebert, D. and Silverman, E.
2002TIMP-1 deficiency does not attenuate interstitial fibrosis in obstructive nephropathy.
Kim H and Oda T and López-Guisa J and Wing D and Edwards DR and Soloway PD and Eddy AA
PubMed: 11274235
04/2001Role of cellular infiltrates in response to proteinuria.
Eddy A
PubMed: 11158857
01/2001PAI-1 deficiency attenuates the fibrogenic response to ureteral obstruction
Kidney International
Oda, T. and Jung, Y.O. and Kim, H.S. and Cai, X. and López-Guisa, J.M. and Ikeda, Y. and Eddy, A.A.
DOI: 10.1046/j.1523-1755.2001.030002587.x
2001TIMP-1 deficiency does not attenuate interstitial fibrosis in obstructive nephropathy
Journal of the American Society of Nephrology
Kim, H. and Oda, T. and López-Guisa, J. and Wing, D. and Edwards, D.R. and Soloway, P.D. and Eddy, A.A.
2001Role of cellular infiltrates in response to proteinuria
American Journal of Kidney Diseases
Eddy, A.A.
DOI: 10.1053/ajkd.2001.20735
2001Mast cells find their way to the kidney
Kidney International
Eddy, A.A.
DOI: 10.1046/j.1523-1755.2001.00811.x
2001Molecular basis of renal fibrosis
Pediatric Nephrology
Eddy, A.A.
DOI: 10.1007/s004670000461
2000Evaluation and management of proteinuria and nephrotic syndrome in children: Recommendations from a pediatric nephrology panel established at the National Kidney Foundation Conference on Proteinuria, Albuminuria, Risk, Assessment, Detection, and Elimination (PARADE)
Pediatrics
Hogg, R.J. and Portman, R.J. and Milliner, D. and Lemley, K.V. and Eddy, A. and Ingelfinger, J.
DOI: 10.1542/peds.105.6.1242
2000Interstitial fibrosis in mice with overload proteinuria: Deficiency of TIMP-1 is not protective
Kidney International
Eddy, A.A. and Kim, H. and López-Guisa, J. and Oda, T. and Soloway, P.D. and McCulloch, L. and Liu, E. and Wing, D.
DOI: 10.1046/j.1523-1755.2000.00208.x
2000A morbid course in a girl with mixed connective tissue disease
Pediatric Nephrology
Essalah, A.A. and Eddy, A.A.
DOI: 10.1007/s004670050562
1999Renal remodelling in dietary protein modified rat polycystic kidney disease
Pediatric Nephrology
Bankovic-Calic, N. and Eddy, A. and Sareen, S. and Ogborn, M.R.
DOI: 10.1007/s004670050744
1999Tubulointerstitial nephritis and uveitis in children and adolescents. Four new cases and a review of the literature
Pediatric Nephrology
Vohra, S. and Eddy, A. and Laxer, R.M. and Levin, A.V. and Taylor, G.
DOI: 10.1007/s004670050634
1999Risk of hemolytic uremic syndrome after sporadic Escherichia coli O157:H7 infection: Results of a Canadian collaborative study
The Journal of Pediatrics
DOI: 10.1016/s0022-3476(98)70303-8
05/1998The nephrotic syndrome: from the simple to the complex.
Eddy AA and Schnaper HW
PubMed: 9613871
05/1998Failure of antioxidant therapy to attenuate interstitial disease in rats with reversible nephrotic syndrome.
Drukker A and Eddy AA
PubMed: 9527400
02/1998Failure of antioxidant therapy to attenuate interstitial disease in rats with reversible nephrotic syndrome
Journal of the American Society of Nephrology
Drukker, A. and Eddy, A.A. and Mcculloch, L. and Liu, E.
1998Interstitial fibrosis in hypercholesterolemic rats: Role of oxidation, matrix synthesis, and proteolytic cascades
Kidney International
Eddy, A.A. and Liu, E. and Mcculloch, L.
DOI: 10.1046/j.1523-1755.1998.00889.x
1998Single photon emission computed tomography scanning in childhood systemic lupus erythematosus
Journal of Rheumatology
Russo, R. and Gilday, D. and Laxer, R.M. and Eddy, A. and Silverman, E.D.
1998The nephrotic syndrome: From the simple to the complex
Seminars in Nephrology
Eddy, A.A. and William Schnaper, H.
1998Molecular insights into renal interstitial fibrosis.
Eddy AA
PubMed: 8989727
12/1996Expression of genes that promote renal interstitial fibrosis in rats with proteinuria.
Eddy AA
PubMed: 8731195
05/1996Molecular insights into renal interstitial fibrosis
Journal of the American Society of Nephrology
Eddy, A.A.
1996Antiribosomal P antibodies in pediatric patients with systemic lupus erythematosus and psychosis
Arthritis and Rheumatism
Press, J. and Palayew, K. and Laxer, R.M. and Elkon, K. and Eddy, A. and Rakoff, D. and Silverman, E.D.
DOI: 10.1002/art.1780390420
1996Interstitial inflammation and fibrosis in rats with diet-induced hypercholesterolemia
Kidney International
Eddy, A.A.
DOI: 10.1038/ki.1996.421
1996Expression of genes that promote renal interstitial fibrosis in rats with proteinuria
Kidney International, Supplement
Eddy, A.A.
1996Expression and function of monocyte chemoattractant protein-1 in experimental nephrotic syndrome
Clinical Immunology and Immunopathology
Eddy, A.A. and Warren, J.S.
DOI: 10.1006/clin.1996.0023
1996Renal expression of genes that promote interstitial inflammation and fibrosis in rats with protein-overload proteinuria
Kidney International
Eddy, A.A. and Giachelli, C.M.
DOI: 10.1038/ki.1995.218
1995Neurologic manifestations of pediatric systemic lupus erythematosus
Pediatric Neurology
Steinlin, M.I. and Blaser, S.I. and Gilday, D.L. and Eddy, A.A. and Logan, W.J. and Laxer, R.M. and Silverman, E.D.
DOI: 10.1016/0887-8994(95)00110-2
1995Interstitial macrophages as mediators of renal fibrosis
Experimental Nephrology
Eddy, A.A.
1995An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes
Molecular and Cellular Biology
Zhang, L. and Eddy, A. and Teng, Y.-T. and Fritzler, M. and Kluppel, M. and Melet, F. and Bernstein, A.
DOI: 10.1128/MCB.15.12.6961
1995Experimental insights into the tubulointerstitial disease accompanying primary glomerular lesions.
Eddy AA
PubMed: 7893992
12/1994Xanthogranulomatous pyelonephritis in children. Etiology, pathogenesis, clinical and radiologic features, and management.
Levy M and Baumal R and Eddy AA
PubMed: 8200171
06/1994Protein restriction reduces transforming growth factor-beta and interstitial fibrosis in nephrotic syndrome.
Eddy AA
PubMed: 8023968
06/1994Protein restriction reduces transforming growth factor-ß and interstitial fibrosis in nephrotic syndrome
American Journal of Physiology - Renal Fluid and Electrolyte Physiology
Eddy, A.A.
1994Experimental insights into the tubulointerstitial disease accompanying primary glomerular lesions
Journal of the American Society of Nephrology
Eddy, A.A.
1994Xanthogranulomatous Pyelonephritis in Children: Etiology, Pathogenesis, Clinical and Radiologic Features, and Management
Clinical Pediatrics
Levy, M. and Baumal, R. and Eddy, A.A.
DOI: 10.1177/000992289403300609
1994Renal extracellular matrix accumulation in acute puromycin aminonucleoside nephrosis in rats.
Jones CL and Buch S and Post M and McCulloch L and Liu E and Eddy AA
PubMed: 1281619
12/1992Tubulointerstitial nephritis
Pediatric Nephrology
Jones, C.L. and Eddy, A.A.
DOI: 10.1007/BF00866512
1992The contribution of antibody-mediated cytotoxicity and immune-complex formation to tubulointerstitial disease in passive Heymann nephritis
Clinical Immunology and Immunopathology
Eddy, A.A. and Ho, G.C. and Thorner, P.S.
DOI: 10.1016/0090-1229(92)90021-F
1992Renal extracellular matrix accumulation in acute puromycin aminonucleoside nephrosis in rats
American Journal of Pathology
Jones, C.L. and Buch, S. and Post, M. and McCulloch, L. and Liu, E. and Eddy, A.A.
1992Intrarenal distribution of clusterin following reduction of renal mass
Kidney International
Correa-Rotter, R. and Hostetter, T.H. and Manivel, J.C. and Eddy, A.A. and Rosenberg, M.E.
DOI: 10.1038/ki.1992.144
1992A relationship between proteinuria and acute tubulointerstitial disease in rats with experimental nephrotic syndrome.
Eddy AA and McCulloch L and Liu E and Adams J
PubMed: 2024704
05/1991Presence of thyroid abnormalities in children with systemic lupus erythematosus
The Journal of Pediatrics
Eberhard, B.A. and Laxer, R.M. and Eddy, A.A. and Silverman, E.D.
DOI: 10.1016/S0022-3476(05)80741-3
1991Pulmonary Hemorrhage and Necrotizing Glomerulonephritis Without Glomerular Immune Deposits: Report of Two Cases
American Journal of Kidney Diseases
Jones, C.L. and Shields, M. and Eddy, A.A. and Baumal, R. and O'Neill, M. and Geary, D.F.
DOI: 10.1016/S0272-6386(12)80887-0
1991A relationship between proteinuria and acute tubulointerstitial disease in rats with experimental nephrotic syndrome
American Journal of Pathology
Eddy, A.A. and McCulloch, L. and Liu, E. and Adams, J.
1991Tubulointerstitial nephritis during the heterologous phase of nephrotoxic serum nephritis.
Eddy AA
PubMed: 1956493
1991Localization of clusterin in the epimembranous deposits of passive Heymann nephritis
Kidney International
Eddy, A.A. and Fritz, I.B.
DOI: 10.1038/ki.1991.29
1991Pathogenesis of interstitial fibrosis in chronic purine aminonucleoside nephrosis
Kidney International
Jones, C.L. and Buch, S. and Post, M. and Mcculloch, L. and Liu, E. and Eddy, A.A.
DOI: 10.1038/ki.1991.310
1991Tubulointerstitial nephritis during the heterologous phase of nephrotoxic serum nephritis
Nephron
Eddy, A.A.
DOI: 10.1159/000186569
1991Intraglomerular leukocyte recruitment during nephrotoxic serum nephritis in rats
Clinical Immunology and Immunopathology
Eddy, A.A. and McCulloch, L.M. and Adams, J.A.
DOI: 10.1016/0090-1229(90)90118-A
1990A study by immunofluorescence microscopy of the NC1 domain of collagen type IV in glomerular basement membranes of two patients with hereditary nephritis
Virchows Archiv A Pathological Anatomy and Histopathology
Thorner, P.S. and Baumal, R. and Eddy, A. and Marrano, P.M.
DOI: 10.1007/BF01678979
1990Coagulation abnormalities in chronic peritoneal dialysis
Pediatric Nephrology
Jones, C.L. and Andrew, M. and Eddy, A. and O'Neil, M. and Ish Shalom, N. and Balfe, J.W.
DOI: 10.1007/BF00858827
1990Interstitial nephritis induced by protein-overload proteinuria.
Eddy AA
PubMed: 2801886
10/1989Characterization of the NC1 domain of collagen type IV in glomerular basement membranes (GBM) and of antibodies to GBM in a patient with anti-GBM nephritis.
Thorner PS and Baumal R and Eddy A and Marrano P
PubMed: 2706812
03/1989Characterization of the NC1 domain of collagen type IV in glomerular basement membranes (GBM) and of antibodies to GBM in a patient with anti-GBM nephritis
Clinical Nephrology
Thorner, P.S. and Baumal, R. and Eddy, A. and Marrano, P.
1989Interstitial nephritis induced by protein-overload proteinuria
American Journal of Pathology
Eddy, A.A.
1989Prolongation of acute renal failure in two patients with hemolytic-uremic syndrome due to excessive plasma infusion therapy
Pediatric Nephrology
Eddy, A.A. and Geary, D.F. and Balfe, J.W. and Clark, W.F. and Baumal, R.
DOI: 10.1007/BF00850219
1989Acute tubulointerstitial nephritis associated with aminonucleoside nephrosis
Kidney International
Eddy, A.A. and Michael, A.F.
DOI: 10.1038/ki.1988.3
1988Demonstration by light microscopy of cytomegalovirus on a renal biopsy of a renal allograft recipient: Confirmation by immunohistochemistry and in situ hybridization
Nephron
Payton, D. and Thorner, P. and Eddy, A. and Yeger, H. and Baumal, R.
DOI: 10.1159/000184493
1987Identification of lymphohemopoietic cells in the kidneys of normal rats.
Eddy AA and Crary GS and Michael AF
PubMed: 3488687
08/1986Subtotal nephrectomy in the rabbit: a model of chronic hypercalcemia, nephrolithiasis, and obstructive nephropathy.
Eddy AA and Falk RJ and Sibley RK and Hostetter TH
PubMed: 3711720
06/1986Identification of lymphohemopoietic cells in the kidneys of normal rats
American Journal of Pathology
Eddy, A.A. and Crary, G.S. and Michael, A.F.
1986Subtotal nephrectomy in the rabbit: A model of chronic hypercalcemia, nephrolithiasis, and obstructive nephropathy
The Journal of Laboratory and Clinical Medicine
Eddy, A.A. and Falk, R.J. and Sibley, R.K. and Hostetter, T.H.
1986Pseudohermaphroditism, glomerulopathy, and Wilms tumor (Drash syndrome): Frequency in end-stage renal failure
The Journal of Pediatrics
Eddy, A.A. and Mauer, S.M.
DOI: 10.1016/S0022-3476(85)80076-7
1985Decreased plasma fibronectin levels in children with hemolytic-uremic syndrome
The American Journal of Medicine
Cosio, F.G. and Eddy, A. and Mentser, M.I. and Bergstein, J.M.
DOI: 10.1016/0002-9343(85)90394-8
1985Reply
The Journal of Pediatrics
Eddy, A. and Mauer, S.M.
DOI: 10.1016/S0022-3476(85)80211-0
1985Renal allograft failure due to recurrent dense intramembranous deposit disease.
Eddy A and Sibley R and Mauer SM and Kim Y
PubMed: 6380848
06/1984The distribution of the CR3 receptor on human cells and tissue as revealed by a monoclonal antibody
Clinical Immunology and Immunopathology
Eddy, A. and Newman, S.L. and Cosio, F. and LeBien, T. and Michael, A.
DOI: 10.1016/0090-1229(84)90090-4
1984Renal allograft failure due to recurrent dense intramembranous deposit disease
Clinical Nephrology
Eddy, A. and Sibley, R. and Maurer, S.M. and Kim, Y.
1984Immune cell populations in cutaneous delayed-type hypersensitivity
Journal of Experimental Medicine
Platt, J.L. and Grant, B.W. and Eddy, A.A. and Michael, A.F.
DOI: 10.1084/jem.158.4.1227
1983 - Research
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Grants
T32 DK07662 (Eddy PI). NIH/NRSA, Pediatric Nephrology Training Program, $274,895 current year. (2006-2016). The goal is to train academic pediatric nephrologists.
N/A (Okamura PI, Eddy Co-PI). Cystinosis Research Foundation, "Elucidating the Role of Cystinosin-Deficient Macrophages in Nephropathic Cystinosis", $218,966/2 years. (2011-2013). The goal of this project is to investigate the hypothesis that cystinosin deficiency leads to macrophage dysfunction that contributes to the pathogenesis of chronic kidney disease.
Pilot and Feasibility Grant (Eddy PI). Washington Global Health Alliance, Impact of Kidney Dysfunction on Mortality Rates in Ugandan Children Hospitalized with Acute Infections. $75,000. (2007-2010). The goal of this project is to establish a mechanism to evaluate renal function for children admitted to Mulago hospital with pneumonia, malaria and gastroenteritis and to determine the impact of renal failure on acute mortality rates.
Honours & AwardsElected to the Council of the International Society of Pediatric Nephrology (1995-2001) and the International Society of Nephrology (2009-2015).
Scientific Program Committee Co-chair for triannual congresses on the International Society of Pediatric Nephrology in 1989, 2011 and 2013.
First recipient of The Robert O. Hickman Endowed Chair in Pediatric Nephrology, University of Washington (2007-2012).
Research Group MembersAlice So, Division Administrative Secretary
Dr. Allison Eddy, in her words
Dr. Allison Eddy is a clinician scientist at BC Children's Hospital. Here she talks about how she found her research focus and shares advice on finding the perfect work-life balance "recipe".
