Congratulations to the BC Children's Hospital Research Institute (BCCHR) and Women’s Health Research Institute (WHRI) investigators and their teams who were awarded funding through the Canadian Institutes of Health Research (CIHR) Fall 2021 Project Grant competition. Our research community received around $6 million in new research grants as principal investigators or co-investigators.
- Overview
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The major aim of my research is to identify changes in the brains of individuals with schizophrenia, bipolar disorder and major depressive disorder that may elucidate the etiology of these disorders and provide clues to novel treatments. Current projects focus on white matter pathology and inflammation. In addition, we study the effects of antipsychotic medications on the brain.
- Publications
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Severe symptoms predict salivary interleukin-6, interleukin-1ß, and tumor necrosis factor-a levels in children and youth with obsessive-compulsive disorder
Journal of Psychosomatic Research
Westwell-Roper, C. and Best, J.R. and Naqqash, Z. and Au, A. and Lin, B. and Lu, C. and Shao, L. and Beasley, C.L. and Stewart, S.E.
DOI: 10.1016/j.jpsychores.2022.110743
2022Diminished levels of the chemokine fractalkine in post-mortem prefrontal cortex in schizophrenia but not bipolar disorder
The World Journal of Biological Psychiatry
Sarah L. Hill and Li Shao and Clare L. Beasley
DOI: 10.1080/15622975.2020.1755451
02/2021Diffusion kurtosis imaging of white matter in bipolar disorder
Vina M Goghari and Mavis Kusi and Mohammed K Shakeel and Clare Beasley and Szabolcs David and Alexander Leemans and Alberto De Luca and Louise Emsell
DOI: 10.1101/2021.02.01.21250951
02/2021Diffusion kurtosis imaging of white matter in bipolar disorder
Psychiatry Research - Neuroimaging
Goghari, V.M. and Kusi, M. and Shakeel, M.K. and Beasley, C. and David, S. and Leemans, A. and De Luca, A. and Emsell, L.
DOI: 10.1016/j.pscychresns.2021.111341
2021Prefrontal fatty acid composition in schizophrenia and bipolar disorder: Association with reelin expression
Schizophrenia Research
Beasley, C.L. and Honer, W.G. and Ramos-Miguel, A. and Vila-Rodriguez, F. and Barr, A.M.
DOI: 10.1016/j.schres.2017.05.033
2020Decreased medial entorhinal cortical thickness in olanzapine exposed female rats is not ameliorated by exercise
Pharmacology Biochemistry and Behavior
Woodward, M.L. and Ker, A.H. and Barr, A.M. and Beasley, C.L. and Hercher, C. and Boyda, H.N. and Procyshyn, R.M. and Honer, W.G. and Lang, D.J.
DOI: 10.1016/j.pbb.2019.172834
2020Reduced SNAP25 Protein Fragmentation Contributes to SNARE Complex Dysregulation in Schizophrenia Postmortem Brain
Neuroscience
Alfredo Ramos-Miguel and Kristina Gicas and Jehan Alamri and Clare L. Beasley and Andrew J. Dwork and J. John Mann and Gorazd Rosoklija and Fang Cai and Weihong Song and Alasdair M. Barr and William G. Honer
DOI: 10.1016/j.neuroscience.2018.12.015
11/2019The SNAP25 Interactome in Ventromedial Caudate in Schizophrenia Includes the Mitochondrial Protein ARF1
Neuroscience
Alfredo Ramos-Miguel and Vilte Barakauskas and Jehan Alamri and Masatoshi Miyauchi and Alasdair M. Barr and Clare L. Beasley and Gorazd Rosoklija and J. John Mann and Andrew J. Dwork and Annie Moradian and Gregg B. Morin and William G. Honer
DOI: 10.1016/j.neuroscience.2018.12.045
11/2019Neuroadaptations to antipsychotic drugs: Insights from pre-clinical and human post-mortem studies
Neuroscience & Biobehavioral Reviews
Davide Amato and Clare L. Beasley and Margaret K. Hahn and Anthony C. Vernon
DOI: 10.1016/j.neubiorev.2016.10.004
05/2017Evidence for altered cell membrane lipid composition in postmortem prefrontal white matter in bipolar disorder and schizophrenia
Journal of Psychiatric Research
Sanjoy Ghosh and Roger A. Dyer and Clare L. Beasley
DOI: 10.1016/j.jpsychires.2017.08.009
2017Deficits in axon-associated proteins in prefrontal white matter in bipolar disorder but not schizophrenia
Bipolar Disord
Li Shao and Khashayar Golbaz and William G Honer and Clare L Beasley
DOI: 10.1111/bdi.12395
05/2016Quantitative mass spectrometry reveals changes in SNAP-25 isoforms in schizophrenia
Schizophrenia Research
Vilte E. Barakauskas and Annie Moradian and Alasdair M. Barr and Clare L. Beasley and Gorazd Rosoklija and J. John Mann and Boro Ilievski and Aleksandar Stankov and Andrew J. Dwork and Peter Falkai and Gregg B. Morin and William G. Honer
DOI: 10.1016/j.schres.2016.03.002
03/2016Increased SNARE Protein-Protein Interactions in Orbitofrontal and Anterior Cingulate Cortices in Schizophrenia
Biological Psychiatry
Alfredo Ramos-Miguel and Clare L. Beasley and Andrew J. Dwork and J. John Mann and Gorazd Rosoklija and Alasdair M. Barr and William G. Honer
DOI: 10.1016/j.biopsych.2014.12.012
09/2015Effects of haloperidol and clozapine administration on oxidative stress in rat brain, liver and serum
Neuroscience Letters
Ana C. Andreazza and Vilte E. Barakauskas and Salar Fazeli and Abigail Feresten and Li Shao and Vivien Wei and Che Hsuan Wu and Alasdair M. Barr and Clare L. Beasley
DOI: 10.1016/j.neulet.2015.02.028
03/2015Loss of Munc18-1 long splice variant in GABAergic terminals is associated with cognitive decline and increased risk of dementia in a community sample
Mol Neurodegeneration
Alfredo Ramos-Miguel and Christa Hercher and Clare L. Beasley and Alasdair M. Barr and Thomas A. Bayer and Peter Falkai and Sue E. Leurgans and Julie A. Schneider and David A. Bennett and William G. Honer
DOI: 10.1186/s13024-015-0061-4
2015Exercise prevents downregulation of hippocampal presynaptic proteins following olanzapine-elicited metabolic dysregulation in rats: Distinct roles of inhibitory and excitatory terminals
Neuroscience
Ramos-Miguel, A. and Honer, W.G. and Boyda, H.N. and Sawada, K. and Beasley, C.L. and Procyshyn, R.M. and Barr, A.M.
DOI: 10.1016/j.neuroscience.2015.06.022
2015Evidence for morphological alterations in prefrontal white matter glia in schizophrenia and bipolar disorder
J Psychiatry Neurosci
DOI: 10.1503/jpn.130277
11/2014Proteomic and metabolomic evidence for glial alterations in schizophrenia
Advances in Biological Psychiatry
Beasley, C.L. and Barakauskas, V.E.
DOI: 10.1159/000358027
2014Increased expression of glial fibrillary acidic protein in prefrontal cortex in psychotic illness
Schizophrenia Research
Abigail H. Feresten and Vilte Barakauskas and Athena Ypsilanti and Alasdair M. Barr and Clare L. Beasley
DOI: 10.1016/j.schres.2013.07.024
10/2013Increased Hippocampal Neurogenesis and p21 Expression in Depression: Dependent on Antidepressants, Sex, Age, and Antipsychotic Exposure
Neuropsychopharmacology
Jonathan R Epp and Clare L Beasley and Liisa AM Galea
DOI: 10.1038/npp.2013.132
05/2013Glucocorticoids increase protein carbonylation and mitochondrial dysfunction
Hormone and Metabolic Research
Tang, V.M. and Young, A.H. and Tan, H. and Beasley, C. and Wang, J.-F.
DOI: 10.1055/s-0033-1345119
2013Effects of chronic exercise and treatment with the antipsychotic drug olanzapine on hippocampal volume in adult female rats
Neuroscience
Barr, A.M. and Wu, C.H. and Wong, C. and Hercher, C. and Töpfer, E. and Boyda, H.N. and Procyshyn, R.M. and Honer, W.G. and Beasley, C.L.
DOI: 10.1016/j.neuroscience.2013.10.010
2013Decreased mRNA expression of uncoupling protein 2, a mitochondrial proton transporter, in post-mortem prefrontal cortex from patients with bipolar disorder and schizophrenia
Neuroscience Letters
Gigante, A.D. and Andreazza, A.C. and Lafer, B. and Yatham, L.N. and Beasley, C.L. and Young, L.T.
DOI: 10.1016/j.neulet.2011.09.064
2011ApoE and cholesterol in schizophrenia and bipolar disorder: Comparison of grey and white matter and relation with APOE genotype
Journal of Psychiatry and Neuroscience
Vila-Rodriguez, F. and Honer, W.G. and Innis, S.M. and Wellington, C.L. and Beasley, C.L.
DOI: 10.1503/jpn.090116
2011Effects of sub-chronic clozapine and haloperidol administration on brain lipid levels
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Vilte E. Barakauskas and Athena R. Ypsilanti and Alasdair M. Barr and Sheila M. Innis and William G. Honer and Clare L. Beasley
DOI: 10.1016/j.pnpbp.2010.03.010
05/2010A Novel Mechanism and Treatment Target for Presynaptic Abnormalities in Specific Striatal Regions in Schizophrenia
Neuropsychopharmacology
Vilte E Barakauskas and Clare L Beasley and Alasdair M Barr and Athena R Ypsilanti and Hong-Ying Li and Allen E Thornton and Hubert Wong and Gorazd Rosokilja and J John Mann and Branislav Mancevski and Zlatko Jakovski and Natasha Davceva and Boro Ilievski and Andrew J Dwork and Peter Falkai and William G Honer
DOI: 10.1038/npp.2009.228
01/2010Metabolic abnormalities in fronto-striatal-thalamic white matter tracts in schizophrenia
Schizophrenia Research
Clare L. Beasley and Andrew J. Dwork and Gorazd Rosoklija and J. John Mann and Branislav Mancevski and Zlatko Jakovski and Natasa Davceva and Andrew R. Tait and Suzana K. Straus and William G. Honer
DOI: 10.1016/j.schres.2009.01.017
04/2009Two-dimensional assessment of cytoarchitecture in the superior temporal white matter in schizophrenia, major depressive disorder and bipolar disorder
Schizophrenia Research
Clare L. Beasley and Mrinalini Honavar and Ian P. Everall and David Cotter
DOI: 10.1016/j.schres.2009.09.028
2009Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder
Molecular Psychiatry
Pennington, K. and Beasley, C.L. and Dicker, P. and Fagan, A. and English, J. and Pariante, C.M. and Wait, R. and Dunn, M.J. and Cotter, D.R.
DOI: 10.1038/sj.mp.4002098
2008Proteomic analysis of the anterior cingulate cortex in the major psychiatric disorders: Evidence for disease-associated changes
Proteomics
Clare L. Beasley and Kyla Pennington and Aine Behan and Robin Wait and Michael J. Dunn and David Cotter
DOI: 10.1002/pmic.200500069
06/2006Erratum (Retracted article): Expression of Oct-6, a POU III domain transcription factor, in schizophrenia (American Journal of Psychiatry (2002) 159 (1174-1182))
American Journal of Psychiatry
Beasley, C. and Meijer, D. and Kerwin, R. and Cotter, D. and Everall, I.A.N. and Price, J.
DOI: 10.1176/appi.ajp.163.8.1454
2006Calprotectin in microglia from frontal cortex is up-regulated in schizophrenia: Evidence for an inflammatory process?
European Journal of Neuroscience
Foster, R. and Kandanearatchi, A. and Beasley, C. and Williams, B. and Khan, N. and Fagerhol, M.K. and Everall, I.P.
DOI: 10.1111/j.1460-9568.2006.05219.x
2006Reductions in cholesterol and synaptic markers in association cortex in mood disorders
Bipolar Disorders
Clare L Beasley and William G Honer and Klaus Bergmann and Peter Falkai and Dieter Lutjohann and Thomas A Bayer
DOI: 10.1111/j.1399-5618.2005.00239.x
10/2005Evidence for altered neuronal organisation within the planum temporale in major psychiatric disorders
Schizophrenia Research
Clare L. Beasley and Gursharan Chana and Mrinalini Honavar and Sabine Landau and Ian P. Everall and David Cotter
DOI: 10.1016/j.schres.2004.08.011
02/2005Optimization of the first dimension for separation by two-dimensional gel electrophoresis of basic proteins from human brain tissue
Proteomics
Kyla Pennington and Emma McGregor and Clare L. Beasley and Ian Everall and David Cotter and Michael J. Dunn
DOI: 10.1002/pmic.200300624
01/2004Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: evidence for decreased neuronal somal size and increased neuronal density
Biological Psychiatry
Gursharan Chana and Sabine Landau and Clare Beasley and Ian P Everall and David Cotter
DOI: 10.1016/s0006-3223(03)00114-8
06/2003Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: Evidence for decreased neuronal somal size and increased neuronal density
Biological Psychiatry
Chana, G. and Landau, S. and Beasley, C. and Everall, I.P. and Cotter, D.
DOI: 10.1016/S0006-3223(03)00114-8
2003Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins
Biological Psychiatry
Clare L Beasley and Zhi J Zhang and Iain Patten and Gavin P Reynolds
DOI: 10.1016/s0006-3223(02)01360-4
10/2002Expression of Oct-6, a POU III Domain Transcription Factor, in Schizophrenia
American Journal of Psychiatry
Maria Ilia and Clare Beasley and Dies Meijer and Robert Kerwin and David Cotter and Ian Everall and Jack Price
DOI: 10.1176/appi.ajp.159.7.1174
07/2002The density and spatial distribution of gabaergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia
Biological Psychiatry
David Cotter and Sabine Landau and Clare Beasley and Robert Stevenson and Gursharon Chana and Laura MacMillan and Ian Everall
DOI: 10.1016/s0006-3223(01)01243-4
03/2002Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder
Cerebral Cortex
Cotter, D. and Mackay, D. and Chana, G. and Beasley, C. and Landau, S. and Everall, I.P.
2002Understanding the neurotransmitter pathology of schizophrenia: Selective deficits of subtypes of cortical GABAergic neurons
Journal of Neural Transmission
Reynolds, G.P. and Beasley, C.L. and Zhang, Z.J.
DOI: 10.1007/s007020200072
2002Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins
Biological Psychiatry
Beasley, C.L. and Zhang, Z.J. and Patten, I. and Reynolds, G.P.
DOI: 10.1016/S0006-3223(02)01360-4
2002Density and distribution of white matter neurons in schizophrenia, bipolar disorder and major depressive disorder: No evidence for abnormalities of neuronal migration
Molecular Psychiatry
Beasley, C.L. and Cotter, D.R. and Everall, I.P.
DOI: 10.1038/sj.mp.4001038
2002An investigation of the Wnt-signalling pathway in the prefrontal cortex in schizophrenia, bipolar disorder and major depressive disorder
Schizophrenia Research
Beasley, C. and Cotter, D. and Everall, I.
DOI: 10.1016/S0920-9964(01)00376-0
2002The density and spatial distribution of GABAergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia
Biological Psychiatry
Cotter, D. and Landau, S. and Beasley, C. and Stevenson, R. and Chana, G. and MacMillan, L. and Everall, I.
DOI: 10.1016/S0006-3223(01)01243-4
2002Neurochemical correlates of cortical GABAergic deficits in schizophrenia: selective losses of calcium binding protein immunoreactivity
Brain Research Bulletin
Gavin P Reynolds and Zhi Jun Zhang and Clare L Beasley
DOI: 10.1016/s0361-9230(01)00526-3
07/2001GABAergic neuronal subtypes in the human frontal cortex — development and deficits in schizophrenia
Journal of Chemical Neuroanatomy
Gavin P Reynolds and Clare L Beasley
DOI: 10.1016/s0891-0618(01)00113-2
07/2001Glycogen synthase kinase-3ß immunoreactivity is reduced in the prefrontal cortex in schizophrenia
Neuroscience Letters
Clare Beasley and David Cotter and Nadeem Khan and Claire Pollard and Paul Sheppard and Ian Varndell and Simon Lovestone and Brian Anderton and Ian Everall
DOI: 10.1016/s0304-3940(01)01688-3
04/2001Glycogen synthase kinase-3ß immunoreactivity is reduced in the prefrontal cortex in schizophrenia
Neuroscience Letters
Beasley, C. and Cotter, D. and Khan, N. and Pollard, C. and Sheppard, P. and Varndell, I. and Lovestone, S. and Anderton, B. and Everall, I.
DOI: 10.1016/S0304-3940(01)01688-3
2001Neurochemical correlates of cortical GABAergic deficits in schizophrenia: Selective losses of calcium binding protein immunoreactivity
Brain Research Bulletin
Reynolds, G.P. and Zhang, Z.J. and Beasley, C.L.
DOI: 10.1016/S0361-9230(01)00526-3
2001GABAergic neuronal subtypes in the human frontal cortex - Development and deficits in schizophrenia
Journal of Chemical Neuroanatomy
Reynolds, G.P. and Beasley, C.L.
DOI: 10.1016/S0891-0618(01)00113-2
2001Neurochemical studies of AIDS and schizophrenia in post-mortem brain tissue
Journal of Neural Transmission
Reynolds, G.P. and Sardar, A.M. and Beasley, C.L. and Aparicio-Legarza, M.I.
1997Parvalbumin-immunoreactive neurons are reduced in the prefrontal cortex of schizophrenics
Schizophrenia Research
Beasley, C.L. and Reynolds, G.P.
DOI: 10.1016/S0920-9964(96)00122-3
1997Brain development: the clinical perspective
Disorders of Brain and Mind
Clare Beasley and Brenda Williams and Ian Everall
DOI: 10.1017/cbo9780511550072.005 - Research
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Research Group Members
Si-ah Choi
Ninon Freidel, Masters Student
James Heap, Registered Psychiatric Nurse, Forensic Liaison
Sangeetha Kasturi, Graduate Research Assistant
Kaitlin Law, Co-op Student
Sarah Grace Lim, Undergraduate Student
Rebecca Lim, Summer Student
Heather Lu, Summer Student
Mitchell Mazza, Summer Student
Li Shao, Research Asst/Tech 3
Jeffrey Sheppard, Summer Student
Alex Willis, Undergraduate Student
