My research interests are in the area of Allergy and Clinical Immunology. The immune system plays a critical role in protecting hosts from infection. Primary immunodeficiency encompasses a group of disorders whereby parts of the immune system may be defective or missing, often resulting in severe, invasive or recurrent infections, autoimmunity and malignancy. The genetic makeup of an individual and the response of the immune system to external environmental factors can result in allergic disorders and disease. There is a strong relationship between conditions such as asthma, food allergy and atopic dermatitis - all of which have an underlying immunological basis. My research aims to study these disorders and apply knowledge translation strategies to empower patients, families and their physicians.
Cost-effectiveness analysis of 21-valent pneumococcal conjugated vaccine among adults in Canada
Raphael Ximenes and Alison E. Simmons and Gebremedhin B. Gebretekle and Austin Nam and Eva Wong and Marina I. Salvadori and Alyssa R. Golden and Beate Sander and Kyla J. Hildebrand and Matthew Tunis and Ashleigh R. Tuite
DOI: 10.1101/2024.10.21.24315770
10/2024
A multimorphic variant in ThPOK causes a novel human disease characterized by T cell abnormalities, immunodysregulation, allergy, and fibrosis
medRxiv
DOI: 10.1101/2024.06.26.24309360
2024
Vaccination and egg allergy: Considerations for family physicians,La vaccination et l’allergie aux Œufs Facteurs que devraient considérer les médecins de famille
Canadian Family Physician
DOI: 10.46747/cfp.700113
2024
Expanding the molecular and phenotypic spectrum of CTLA-4 insufficiency
Pediatric Allergy and Immunology
DOI: 10.1111/pai.14077
2024
Should “primary immune disorder” replace “inborn error of immunity”? Names matter, but there is room for both
Journal of Allergy and Clinical Immunology
DOI: 10.1016/j.jaci.2024.04.007
2024
Revaccination outcomes among adolescents and adults with suspected hypersensitivity reactions following COVID-19 vaccination: A Canadian immunization research network study
Vaccine
DOI: 10.1016/j.vaccine.2024.06.045
2024
Inborn errors of immunity in adulthood
Allergy, Asthma and Clinical Immunology
DOI: 10.1186/s13223-023-00862-8
2024
Vaccination and egg allergy
Canadian Family Physician
DOI: 10.46747/cfp.700110
2024
Vaccination contre la rougeole
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
DOI: 10.1503/cmaj.240371-f
2024
Measles vaccination
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
DOI: 10.1503/cmaj.240371
2024
A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency
Science Immunology
DOI: 10.1126/sciimmunol.ade7953
2023
Trends in the proportion of women speakers at North American Allergy and Immunology conferences, 2008 to 2020
Annals of Allergy, Asthma and Immunology
DOI: 10.1016/j.anai.2023.08.607
2023
A germline heterozygous dominant negative IKZF2 variant causing syndromic primary immune regulatory disorder and ICHAD
medRxiv
DOI: 10.1101/2023.09.09.23295301
2023
Homozygous RMRP Promoter Duplications Cause Severely Reduced Transcript Abundance and SCID Associated with Cartilage Hair Hypoplasia
Journal of Clinical Immunology
DOI: 10.1007/s10875-023-01489-5
2023
Vaccine anaphylaxis and Canadian public health policy
The Lancet Respiratory Medicine
Abrams, E.M. and Zafack, J.G. and Ismail, S.J. and Bettinger, J.A. and Hildebrand, K.J. and Tunis, M.C.
DOI: 10.1016/S2213-2600(23)00037-1
2023
Dominant negative variants in IKZF2 cause ICHAD syndrome, a new disorder characterised by immunodysregulation, craniofacial anomalies, hearing impairment, athelia and developmental delay
Journal of Medical Genetics
DOI: 10.1136/jmg-2022-109127
2023
Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia
Journal of Experimental Medicine
DOI: 10.1084/jem.20220170
2023
Human ASXL1 Deficiency Causes Epigenetic Dysfunction, Combined Immunodeficiency and EBV–Associated Hodgkin Lymphoma
medRxiv
DOI: 10.1101/2023.12.20.23300096
2023
Evaluation of rotavirus vaccine administration among a 22q11.2DS patient population
Allergy, Asthma & Clinical Immunology
Sophie McGregor and Matthew Boroditsky and Geraldine Blanchard-Rohner and Christine Loock and Kyla Jade Hildebrand
DOI: 10.1186/s13223-022-00693-z
12/2022
Real-world peanut OIT in infants may be safer than non-infant preschool OIT and equally effective
Journal of Allergy and Clinical Immunology: In Practice
Soller, L. and Carr, S. and Kapur, S. and Rex, G.A. and McHenry, M. and Cook, V.E. and Leo, S. and Wong, T. and Vander Leek, T.K. and Gerstner, T.V. and Yeung, J. and Abrams, E.M. and Mak, R. and Hildebrand, K.J. and Erdle, S.C. and Cameron, S.B. and Chan, E.S.
DOI: 10.1016/j.jaip.2021.12.009
2022
Revaccination and Adverse Event Recurrence in Patients with Adverse Events following Immunization
Journal of Pediatrics
Mu{\~n}oz, C.E. and MacDonald, B. and Pham-Huy, A. and Vaudry, W. and Pernica, J.M. and Boucher, F.D. and Constantinescu, C. and Sadarangani, M. and Bettinger, J.A. and Tapi{\'e}ro, B. and Morris, S.K. and McConnell, A. and Cowan, J. and Zafack, J. and Upton, J. and Abdurrahman, Z. and McHenry, M. and Hildebrand, K.J. and Noya, F. and De Serres, G. and Halperin, S.A. and Top, K.A.
DOI: 10.1016/j.jpeds.2022.07.019
2022
Diverse clinical features and diagnostic delay in monogenic inborn errors of immunity: A call for access to genetic testing
Pediatric Allergy and Immunology
Branch, A. and Modi, B. and Bahrani, B. and Hildebrand, K.J. and Cameron, S.B. and Junker, A.K. and Turvey, S.E. and Biggs, C.M.
DOI: 10.1111/pai.13571
2021
CSACI position statement: transition recommendations on existing epinephrine autoinjectors
Allergy, Asthma and Clinical Immunology
Li, L.D.X. and Abrams, E.M. and Lavine, E. and Hildebrand, K. and Mack, D.P.
DOI: 10.1186/s13223-021-00634-2
2021
Anaphylaxis to parenteral nutrition in a pediatric oncology patient treated with induction of drug tolerance protocol
Journal of Allergy and Clinical Immunology: In Practice
Wachnian, C.J. and Baadjes, B. and Cheng, S. and Ramanzin, A. and Hildebrand, K.J.
DOI: 10.1016/j.jaip.2020.10.016
2021
Idiopathic splenomegaly in childhood and the spectrum of RAS-associated lymphoproliferative disease: a case report
BMC Pediatrics
Blanchard-Rohner, G. and Ragotte, R.J. and Junker, A.K. and Sharma, M. and Del Bel, K.L. and Lu, H.Y. and Erdle, S. and Chomyn, A. and Gill, H. and Tucker, L.B. and Schreiber, R.A. and Rozmus, J. and Biggs, C.M. and Hildebrand, K.J. and Wu, J. and Stockler-Ipsiroglu, S. and Turvey, S.E.
DOI: 10.1186/s12887-021-02508-3
2021
Evaluation and management of non-IgE-mediated food allergies,L'évaluation et la prise en charge des allergies alimentaires non induites par les IgE
Paediatrics and Child Health (Canada)
Abrams, E.M. and Hildebrand, K.J. and Chan, E.S.
DOI: 10.1093/pch/pxaa132
2021
Non-IgE-mediated food allergy: Evaluation and management
Paediatrics and Child Health (Canada)
Abrams, E.M. and Hildebrand, K.J. and Chan, E.S.
DOI: 10.1093/pch/pxaa131
2021
Septic arthritis due to Mycoplasma orale in a young patient with hypogammaglobulinemia
JAMMI
Liu, A.C. and Harvey, M. and Lee, A. and Hildebrand, K. and Hoang, L. and Gantt, S. and Al-Rawahi, G.N.
DOI: 10.3138/JAMMI-2021-0002
2021
Inborn errors of immunity manifesting as atopic disorders
Journal of Allergy and Clinical Immunology
Vaseghi-Shanjani, M. and Smith, K.L. and Sara, R.J. and Modi, B.P. and Branch, A. and Sharma, M. and Lu, H.Y. and James, E.L. and Hildebrand, K.J. and Biggs, C.M. and Turvey, S.E.
DOI: 10.1016/j.jaci.2021.08.008
2021
First Real-World Effectiveness Analysis of Preschool Peanut Oral Immunotherapy
Journal of Allergy and Clinical Immunology: In Practice
Soller, L. and Abrams, E.M. and Carr, S. and Kapur, S. and Rex, G.A. and Leo, S. and McHenry, M. and Vander Leek, T.K. and Yeung, J. and Cook, V.E. and Wong, T. and Hildebrand, K.J. and Mak, R. and Gerstner, T.V. and Cameron, S.B. and Chan, E.S.
DOI: 10.1016/j.jaip.2020.10.045
2021
Prevention and management of allergic reactions to food in child care centers and schools: Practice guidelines
Journal of Allergy and Clinical Immunology
Waserman, S. and Cruickshank, H. and Hildebrand, K.J. and Mack, D. and Bantock, L. and Bingemann, T. and Chu, D.K. and Cuello-Garcia, C. and Ebisawa, M. and Fahmy, D. and Fleischer, D.M. and Galloway, L. and Gartrell, G. and Greenhawt, M. and Hamilton, N. and Hourihane, J. and Langlois, M. and Loh, R. and Muraro, A. and Rosenfield, L. and Schoessler, S. and Tang, M.L.K. and Weitzner, B. and Wang, J. and Brozek, J.L.
DOI: 10.1016/j.jaci.2021.01.034
2021
First pediatric electronic algorithm to stratify risk of penicillin allergy
Allergy, Asthma and Clinical Immunology
Roberts, H. and Soller, L. and Ng, K. and Chan, E.S. and Roberts, A. and Kang, K. and Hildebrand, K.J. and Wong, T.
DOI: 10.1186/s13223-020-00501-6
2020
Clinical IRAK4 deficiency caused by homozygosity for the novel IRAK4 (c.1049delG, p.Gly350Glufs*15) variant
Cold Spring Harbor Molecular Case Studies
Jia, A. and James, E. and Lu, H.Y. and Sharma, M. and Modi, B.P. and Biggs, C.M. and Hildebrand, K.J. and Chomyn, A. and Erdle, S. and Kular, H. and Turvey, S.E.
DOI: 10.1101/MCS.A005298
2020
Timing of introduction of allergenic solids for infants at high risk.
Paediatrics & Child Health
Abrams EM and Hildebrand K and Blair B and Chan ES
DOI: 10.1093/pch/pxy195
PubMed: 30833823
02/2019
First Real-World Safety Analysis of Preschool Peanut Oral Immunotherapy
Journal of Allergy and Clinical Immunology: In Practice
Soller, L. and Abrams, E.M. and Carr, S. and Kapur, S. and Rex, G.A. and Leo, S. and Lidman, P.G. and Yeung, J. and Vander Leek, T.K. and McHenry, M. and Wong, T. and Cook, V.E. and Hildebrand, K.J. and Gerstner, T.V. and Mak, R. and Lee, N.J. and Cameron, S.B. and Chan, E.S.
DOI: 10.1016/j.jaip.2019.04.010
2019
Extended analysis of parent and child confidence in recognizing anaphylaxis and using the epinephrine autoinjector during oral food challenges
Journal of Allergy and Clinical Immunology: In Practice
Soller, L. and Teoh, T. and Baerg, I. and Wong, T. and Hildebrand, K.J. and Cook, V.E. and Biggs, C.M. and Lee, N. and Yaworski, L. and Cameron, S.B. and Chan, E.S.
DOI: 10.1016/j.jaip.2018.09.025
2019
Supervised epinephrine autoinjector administration in a cohort of children with anaphylaxis during oral food challenges (OFCs)
Journal of Allergy and Clinical Immunology
Lianne Soller and Timothy Teoh and Ingrid Baerg and Tracy Gonzalez and Tiffany Wong and Kyla J. Hildebrand and Edmond S. Chan
DOI: 10.1016/j.jaci.2017.12.800
02/2018
Early introduction of foods to prevent food allergy
Allergy, Asthma and Clinical Immunology
Chan, E.S. and Abrams, E.M. and Hildebrand, K.J. and Watson, W.
DOI: 10.1186/s13223-018-0286-1
2018
Asthma
Allergy, Asthma and Clinical Immunology
Quirt, J. and Hildebrand, K.J. and Mazza, J. and Noya, F. and Kim, H.
DOI: 10.1186/s13223-018-0279-0
2018
Interstitial lung disease in infancy: an unusual presentation of CD40 ligand deficiency
LymphoSign Journal
Victoria Elizabeth Cook and Connie L Yang and Alexia Dabadie and Joanne Luider and Kyla Jade Hildebrand and Anne K Junker and Stuart Turvey
DOI: 10.14785/lymphosign-2017-0003
06/2017
THE PHENOTYPE OF SEVERE PRESCHOOL ASTHMATICS AND THEIR RESPONSE TO ADD-ON THERAPY.
Paediatrics & Child Health
Seaton C and Hildebrand K and Pow A and Yang C
DOI: 10.1093/pch/pxx086.094
05/2017
Many Children Referred to a Tertiary Care Pediatric Allergy Clinic Do Not Have an Allergy
Journal of Allergy and Clinical Immunology
Victoria E. Cook and Jordan Yeo and Christopher Mill and Kyla Hildebrand and Elodie Portales-Casamar and Edmond S. Chan
DOI: 10.1016/j.jaci.2016.12.134
02/2017
Determinants of Quality of life (QOL) Among Children Undergoing Oral Food Challenge (OFC) in Canada
Journal of Allergy and Clinical Immunology
Lianne Soller and Christopher Mill and Tiffany Wong and Ingrid Baerg and Tracy Gonzalez and Timothy Teoh and Kyla Hildebrand and Edmond S. Chan
DOI: 10.1016/j.jaci.2016.12.137
02/2017
Primum non nocere-first do no harm. And then feed peanut
Allergy, Asthma and Clinical Immunology
Hildebrand, K.J. and Abrams, E.M. and Vander Leek, T.K. and Upton, J.E.M. and Mack, D.P. and Kirste, L. and McCusker, C. and Kapur, S.
DOI: 10.1186/s13223-017-0180-2
2017
Persistent fever in an 8-month-old boy
Pediatrics in Review
Kilvert, M. and Roberts, A. and Hildebrand, K.J.
DOI: 10.1542/pir.2015-0145
2017
IRAK-4 deficiency as a cause for familial fatal invasive infection by Streptococcus pneumoniae
Clinical Immunology
Grazioli, S. and Hamilton, S.J. and McKinnon, M.L. and Del Bel, K.L. and Hoang, L. and Cook, V.E. and Hildebrand, K.J. and Junker, A.K. and Turvey, S.E.
DOI: 10.1016/j.clim.2015.12.007
2016
Impact of supervised epinephrine autoinjector administration during food challenges on parent confidence
Annals of Allergy, Asthma and Immunology
Teoh, T. and Mill, C. and Wong, T. and Baerg, I. and Alexander, A. and Hildebrand, K.J. and Dean, J. and Kuzeljevic, B. and Chan, E.S.
DOI: 10.1016/j.anai.2016.02.020
2016
Mobile health applications in clinical practice: pearls, pitfalls, and key considerations
Annals of Allergy, Asthma and Immunology
Cook, V.E. and Ellis, A.K. and Hildebrand, K.J.
DOI: 10.1016/j.anai.2016.01.012
2016
Epinephrine auto injector administration by parents or patients for anaphylaxis during supervised oral food challenges and assessment of confidence
Allergy, Asthma and Clinical Immunology
Baerg, I. and Alexander, A. and Wong, T. and Teoh, T. and Hildebrand, K. and Leo, S. and Yeung, J. and Dean, J. and Chan, E.
DOI: 10.1186/1710-1492-10-S2-A2
2014
Rifampin hypersensitivity in a 2-year-old child with successful rapid oral desensitization
Pediatric Infectious Disease Journal
Hildebrand, K.J. and Atkinson, A. and Kitai, I.
DOI: 10.1097/INF.0000000000000295
2014
Limitation of TREC-based newborn screening for ZAP70 Severe Combined Immunodeficiency
Clinical Immunology
Grazioli, S. and Bennett, M. and Hildebrand, K.J. and Vallance, H. and Turvey, S.E. and Junker, A.K.
DOI: 10.1016/j.clim.2014.04.015
2014
Human primary immunodeficiencies causing defects in innate immunity
Current Opinion in Allergy and Clinical Immunology
Wong, T. and Yeung, J. and Hildebrand, K.J. and Junker, A.K. and Turvey, S.E.
DOI: 10.1097/ACI.0000000000000010
2013
Vasculitis masquerading as drug allergy: thinking outside the ‘adult’ box of possible diagnoses
Allergy, Asthma & Clinical Immunology
Marie-Elodie Sarre-Annweiler and Mariamma Joseph and Kyla J Hildebrand
DOI: 10.1186/1710-1492-8-s1-a15
2012
Rifampin hypersensitivity in a two year-old child with successful rapid oral desensitization
Allergy, Asthma & Clinical Immunology
KJ Hildebrand and D Hummel
DOI: 10.1186/1710-1492-6-s1-p22
2010
Epinephrine Autoinjector Study
Caregivers and patients in Pediatric Allergy Clinic often report that they are fearful of using an epinephrine autoinjector despite receiving education on indications for use and technique. Given that intramuscular epinephrine is the only medication that can reverse a potentially severe allergic reaction, it is very important that patients and caregivers possess not only the knowledge and ability to use epinephrine autoinjectors, but also have the confidence to administer the medication when clinically indicated. The goal of the Epinephrine Autoinjector study is to assess the impact of self or caregiver-administrated epinephrine in a medically supervised setting on the confidence of patient and/or caregivers for future use of epinephrine autoinjector.
Certified Asthma Educator (CAE) Anaphylaxis Counseling Study
Several of my research projects involve studying the relationship between asthma, allergy and anaphylaxis. Many patients with severe asthma who require admission to intensive care units or repeated hospital admissions have underlying allergic triggers (environmental or food allergy). Poorly controlled asthma is a significant risk factor for anaphylaxis in this patient population. I am assessing the frequency of anaphylaxis counseling performed by a group of CAEs at BC Children’s Hospital and the outcomes associated with this counseling intervention. For patients living in remote areas of British Columbia, there is greater accessibility to CAEs in comparison to pediatric asthma/allergy specialists. There may be a role for curricular innovation to the CAE training programs across Canada to better serve this at-risk patient population.
The CHILD study
this study is a multicenter, multidisciplinary, longitudinal, population-based cohort study of 5000 children. The aim of the study is to test multiple hypotheses within the theme that specific environmental exposures along with genetic and immunological determinants, lead to pathophysiological allergic responses, and that clinical outcomes including asthma may be further modified by lung growth, hormonal and metabolic influences and psychosocial environment. Children were recruited from 4 cities in Canada, including Vancouver and are being followed prospectively.
Royal College of Physicians and Surgeons Canada Fellowship for Studies in Medical Education (2010)
Each year, the University of British Columbia faculty of medicine recognizes faculty and staff members for excellence in teaching, research, administration, innovation and public service.
Congratulations to the BC Children’s Hospital Research Institute investigators and staff members who are recognized in the 2022 UBC Faculty of Medicine Awards:
BC Children’s Hospital investigator Dr. Kyla Hildebrand not only conducts research in the area of allergy and clinical immunology, but this clinical assistant professor in the Department of Pediatrics in the Faculty of Medicine at the University of British Columbia is also well known for her leadership in undergraduate and postgraduate medical education.
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