- Overview
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As a clinician-scientist, my main research focus is on understanding why newborns are vulnerable to infection.
I conduct translational research that integrates clinical and lab-based research methodologies including human immunology & molecular biology research, "-omics"/bioinformatics, epidemiology, and clinical/interventional studies.
As a neonatologist, I also spend part of my time providing medical care to newborns admitted to the neonatal intensive care unit at the BC Women's Hospital.
- Publications
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Effect of Maternal Docosahexaenoic Acid Supplementation on Bronchopulmonary Dysplasia-Free Survival in Breastfed Preterm Infants: A Randomized Clinical Trial
JAMA
Marc, I. and Piedboeuf, B. and Lacaze-Masmonteil, T. and Fraser, W. and Mâsse, B. and Mohamed, I. and Qureshi, M. and Afifi, J. and Lemyre, B. and Caouette, G. and Bartholomew, J. and Nuyt, A.M. and Julien, P. and Synnes, A. and Lucas, M. and Perreault, T. and Strueby, L. and Cieslak, Z. and Yusuf, K. and Pelligra, G. and Massé, E. and Larsen, B. and de Cabo, C. and Ruth, C. and Khurshid, F. and Lavoie, P.M.
DOI: 10.1001/jama.2020.8896
2020Attenuated innate immune defenses in very premature neonates during the neonatal period
Pediatric Research
Marchant, E.A. and Kan, B. and Sharma, A.A. and Van Zanten, A. and Kollmann, T.R. and Brant, R. and Lavoie, P.M.
DOI: 10.1038/pr.2015.132
2015Clinical correlates of human immunodeficiency virus-1 (HIV-1) DNA and inducible HIV-1 RNA reservoirs in peripheral blood in children with perinatally acquired HIV-1 infection with sustained virologic suppression for at least 5 years
Clinical Infectious Diseases
Bitnun, A. and Ransy, D.G. and Brophy, J. and Kakkar, F. and Hawkes, M. and Samson, L. and Annabi, B. and Pagliuzza, A. and Morand, J.-A. and Sauve, L. and Chomont, N. and Lavoie, S. and Kim, J. and Sandstrom, P. and Wender, P.A. and Lee, T. and Singer, J. and Read, S.E. and Soudeyns, H. and Alimenti, A. and Ancuta, P. and Bullard, J. and Chun, T.-W. and Côté, H.C.F. and Embree, J. and Hawkes, M.T. and Karatzios, C. and Kaul, R. and Lamarre, V. and Lapointe, N. and Lavoie, P. and Money, D.M. and Moore, D. and Read, S. and Reinhard, R. and Sandstorm, P. and Seigel, S. and Tan, B. and Vaudry, W.
DOI: 10.1093/cid/ciz251
2020Outcomes related to respiratory syncytial virus with an abbreviated palivizumab regimen in children with congenital heart disease: a descriptive analysis.
CMAJ open
DOI: 10.9778/cmajo.20180167
PubMed: 30782771
01/2019A Time-Based Analysis of Inflammation in Infants at Risk of Bronchopulmonary Dysplasia
Journal of Pediatrics
Leroy, S. and Caumette, E. and Waddington, C. and Hébert, A. and Brant, R. and Lavoie, P.M.
DOI: 10.1016/j.jpeds.2017.09.011
2018Antifungal immunological defenses in newborns
Frontiers in Immunology
Michalski, C. and Kan, B. and Lavoie, P.M.
DOI: 10.3389/fimmu.2017.00281
2017Cord blood hematopoietic cells from preterm infants display altered DNA methylation patterns
Clinical Epigenetics
de Goede, O.M. and Lavoie, P.M. and Robinson, W.P.
DOI: 10.1186/s13148-017-0339-1
2017The phenotype and function of preterm infant monocytes: Implications for susceptibility to infection
Journal of Leukocyte Biology
De Jong, E. and Strunk, T. and Burgner, D. and Lavoie, P.M. and Currie, A.
DOI: 10.1189/jlb.4RU0317-111R
2017An Immunological Perspective on Neonatal Sepsis
Trends in Molecular Medicine
Kan, B. and Razzaghian, H.R. and Lavoie, P.M.
DOI: 10.1016/j.molmed.2016.02.001
2016Outcomes of respiratory syncytial virus immunoprophylaxis in infants using an abbreviated dosing regimen of palivizumab
JAMA Pediatrics
Lavoie, P.M. and Solimano, A. and Taylor, R. and Kwan, E. and Claydon, J. and Turvey, S.E. and Marr, N.
DOI: 10.1001/jamapediatrics.2015.3235
2016Cellular metabolism constrains innate immune responses in early human ontogeny
Nature communications
Kan, B. and Michalski, C. and Fu, H. and Au, H.H.T. and Lee, K. and Marchant, E.A. and Cheng, M.F. and Anderson-Baucum, E. and Aharoni-Simon, M. and Tilley, P. and Mirmira, R.G. and Ross, C.J. and Luciani, D.S. and Jan, E. and Lavoie, P.M.
DOI: 10.1038/s41467-018-07215-9
2018A Novel Anti-nucleocapsid Antibody Avidity Method for Identifying SARS-CoV-2 Reinfections
The Journal of Infectious Diseases
Liam Golding and Allison W Watts and Jacob Shew and Marina Viñeta Paramo and Louise C Mâsse and David M Goldfarb and Bahaa Abu-Raya and Pascal M Lavoie
DOI: 10.1093/infdis/jiae072
09/2024Decreased ß-catenin Protein in Lungs From Human Congenital Diaphragmatic Hernia Archival Pathology Specimens: A Case-control Study
Journal of Pediatric Surgery
DOI: 10.1016/j.jpedsurg.2024.01.034
2024Angiogenesis-associated pathways play critical roles in neonatal sepsis outcomes
Scientific Reports
DOI: 10.1038/s41598-024-62195-9
2024DDIT4L regulates mitochondrial and innate immune activities in early life
JCI Insight
DOI: 10.1172/jci.insight.172312
2024Efficacy of Palivizumab Immunoprophylaxis for Reducing Severe RSV Outcomes in Children with Immunodeficiencies: A Systematic Review
Journal of the Pediatric Infectious Diseases Society
DOI: 10.1093/jpids/piae004
2024Bordetella pertussis infection following relaxation of COVID-19 non-pharmaceutical interventions in 2021–2023 in Vancouver metropolitan area, British Columbia, Canada
Vaccine
DOI: 10.1016/j.vaccine.2024.05.052
2024The epidemiology and risk factors for postnatal complications among postpartum women and newborns in southwestern Uganda: A prospective cohort study
PLOS Global Public Health
DOI: 10.1371/journal.pgph.0003458
2024Lower Neutrophil Count Without Clinical Consequence among Children of African Ancestry Living with HIV in Canada
Journal of Acquired Immune Deficiency Syndromes
DOI: 10.1097/QAI.0000000000003467
2024Total liquid ventilation in an ovine model of extreme prematurity: a randomized study
Pediatric Research
DOI: 10.1038/s41390-023-02841-6
2024Association between Enteral Supplementation with High-Dose Docosahexaenoic Acid and Risk of Bronchopulmonary Dysplasia in Preterm Infants: A Systematic Review and Meta-analysis
JAMA Network Open
DOI: 10.1001/jamanetworkopen.2023.3934
2023Verbal Autopsy to Assess Postdischarge Mortality in Children With Suspected Sepsis in Uganda
Pediatrics
DOI: 10.1542/peds.2023-062011
2023SARS-CoV-2 cross-sectional seroprevalence study among public school staff in Metro Vancouver after the first Omicron wave in British Columbia, Canada
BMJ Open
DOI: 10.1136/bmjopen-2022-071228
2023Loss of Respiratory Syncytial Virus Antibody Functions During the Peak of the COVID-19 Pandemic Mitigation Measures
Journal of the Pediatric Infectious Diseases Society
DOI: 10.1093/jpids/piad099
2023World Health Organization Danger Signs to predict bacterial sepsis in newborns: A pragmatic prospective cohort study
medRxiv
DOI: 10.1101/2023.05.09.23289739
2023Why has the epidemiology of RSV changed during the COVID-19 pandemic?
eClinicalMedicine
DOI: 10.1016/j.eclinm.2023.102089
2023Respiratory syncytial virus epidemiology and clinical severity before and during the COVID-19 pandemic in British Columbia, Canada: a retrospective observational study
Lancet Regional Health - Americas
DOI: 10.1016/j.lana.2023.100582
2023Does Growth Velocity Affect Associations between Birth Weight and Neurodevelopment for Infants Born Very Preterm?
Journal of Pediatrics
DOI: 10.1016/j.jpeds.2023.113531
2023Prediction models for post-discharge mortality among under-five children with suspected sepsis in Uganda: A multicohort analysis
medRxiv
DOI: 10.1101/2023.06.14.23291343
2023Effect of vaccine dosing intervals on Omicron surrogate neutralization after three doses of BNT162b2
Heliyon
DOI: 10.1016/j.heliyon.2023.e17259
2023Anxiety symptoms, psychological distress, and optimism in school staff: Testing associations with stressors and coping during the second year of the COVID-19 pandemic
Journal of Affective Disorders Reports
DOI: 10.1016/j.jadr.2023.100662
2023World Health Organization Danger Signs to predict bacterial sepsis in young infants: A pragmatic cohort study
PLOS Global Public Health
DOI: 10.1371/journal.pgph.0001990
2023Loss of severe respiratory syncytial virus infection-associated antibody function during the peak of the COVID-19 pandemic mitigation measures
medRxiv
DOI: 10.1101/2023.07.30.23292881
2023Mortality after hospital discharge among children younger than 5 years admitted with suspected sepsis in Uganda: a prospective, multisite, observational cohort study
The Lancet Child and Adolescent Health
DOI: 10.1016/S2352-4642(23)00052-4
2023Post-discharge mortality among children under 5 years admitted with suspected sepsis in Uganda: a prospective multi-site study
medRxiv
Wiens, M.O. and Bone, J.N. and Kumbakumba, E. and Businge, S. and Tagoola, A. and Sherine, S.O. and Byaruhanga, E. and Ssemwanga, E. and Barigye, C. and Nsungwa, J. and Olaro, C. and Ansermino, J.M. and Kissoon, N. and Singer, J. and Larson, C.P. and Lavoie, P.M. and Dunsmuir, D. and Moschovis, P.P. and Novakowski, S. and Komugisha, C. and Tayebwa, M. and Mwesigwa, D. and Zhang, C. and Knappett, M. and West, N. and Nguyen, V. and Mugisha, N.K. and Kabakyenga, J.
DOI: 10.1101/2023.01.12.23284164
2023Genetics of bronchopulmonary dysplasia: An update
Seminars in Perinatology
DOI: 10.1016/j.semperi.2023.151811
2023Enteral supplementation with high-dose docosahexaenoic acid on the risk of bronchopulmonary dysplasia in very preterm infants: a collaborative study protocol for an individual participant data meta-analysis
BMJ Open
DOI: 10.1136/bmjopen-2023-076223
2023Implementing genomics in the neonatal period: An assessment of parental decision making and anxiety
Journal of Genetic Counseling
Tasha Wainstein and Teresa Campbell and Biljana J. Stojkova and Pascal M. Lavoie and Alison M. Elliott
DOI: 10.1002/jgc4.1605
12/2022Comparative analysis of pediatric Respiratory Syncytial Virus epidemiology and clinical severity before and during the COVID-19 pandemic in British Columbia, Canada
Marina Viñeta Paramo and Bahaa Abu-Raya and Frederic Reicherz and Rui Yang Xu and Jeffrey N. Bone and Jocelyn A. Srigley and Alfonso Solimano and David M. Goldfarb and Danuta M. Skowronski and Pascal M. Lavoie
DOI: 10.1101/2022.11.18.22282477
11/2022Variability in mRNA SARS-CoV-2 BNT162b2 vaccine immunogenicity is associated with differences in the gut microbiome and habitual dietary fibre intake
Genelle R. Healey and Liam Golding and Alana Schick and Abdelilah Majdoubi and Pascal M. Lavoie and Bruce A. Vallance
DOI: 10.1101/2022.08.24.22279143
08/2022Decay of anti-Bordetella pertussis antibodies in women of childbearing age following COVID-19 non-pharmaceutical measures
Vaccine
Frederic Reicherz and Liam Golding and Pascal M. Lavoie and Bahaa Abu-Raya
DOI: 10.1016/j.vaccine.2022.04.086
06/2022Cell trajectory modeling identifies a primitive trophoblast state defined by BCAM enrichment
Development
Matthew J. Shannon and Jennet Baltayeva and Barbara Castellana and Jasmin Wächter and Gina L. McNeill and Ji Soo Yoon and Jenna Treissman and Hoa T. Le and Pascal M. Lavoie and Alexander G. Beristain
DOI: 10.1242/dev.199840
01/2022Human germline biallelic complete NFAT1 deficiency causes the triad of progressive joint contractures, osteochondromas, and susceptibility to B cell malignancy
medRxiv
Sharma, M. and Fu, M.P. and Lu, H.Y. and Sharma, A.A. and Modi, B.P. and Michalski, C. and Lin, S. and Dalmann, J. and Salman, A. and Del Bel, K.L. and Waqas, M. and Terry, J. and Setiadi, A. and Lavoie, P.M. and Wasserman, W.W. and Mwenifumbo, J. and Kobor, M.S. and Lee, A.F. and Lehman, A. and Cheng, S. and Cooper, A. and Patel, M.S. and Turvey, S.E.
DOI: 10.1101/2022.01.30.22269378
2022Sensitivity of the Elecsys Nucleocapsid Assay for the Detection of Preceding SARS-CoV-2 Infections
Open Forum Infectious Diseases
Grunau, B. and Tom, J. and Asamoah-Boaheng, M. and O{'}Brien, S.F. and Drews, S.J. and Sediqi, S. and Lavoie, P.M. and Barakauskas, V. and Goldfarb, D.M.
DOI: 10.1093/ofid/ofac349
2022Waning Immunity Against Respiratory Syncytial Virus during the Coronavirus Disease 2019 Pandemic
Journal of Infectious Diseases
DOI: 10.1093/infdis/jiac192
2022School staff and teachers during the second year of COVID-19: Higher anxiety symptoms, higher psychological distress, and poorer mental health compared to the general population
Journal of Affective Disorders Reports
Hutchison, S.M. and Watts, A. and Gadermann, A. and Oberle, E. and Oberlander, T.F. and Lavoie, P.M. and Mâsse, L.C.
DOI: 10.1016/j.jadr.2022.100335
2022COVID-19 Vaccine Intentions and Perceptions Among Public School Staff of the Greater Vancouver Metropolitan Area, British Columbia, Canada
Frontiers in Public Health
Watts, A.W. and Hutchison, S.M. and Bettinger, J.A. and Gadermann, A. and Oberle, E. and Oberlander, T.F. and Goldfarb, D.M. and Lavoie, P.M. and M{\^a}sse, L.C.
DOI: 10.3389/fpubh.2022.832444
2022Use of SMOF lipid emulsion in very preterm infants does not affect the incidence of bronchopulmonary dysplasia–free survival
Journal of Parenteral and Enteral Nutrition
Ndiaye, A.B.K.T. and Mohamed, I. and Pronovost, E. and Angoa, G. and Piedboeuf, B. and Lemyre, B. and Afifi, J. and Qureshi, M. and S{\'e}ri{\`e}s, T. and Guillot, M. and Simonyan, D. and Yusuf, K. and Lavoie, P.M. and Fraser, W.D. and M{\^a}sse, B. and Nuyt, A.M. and Lacaze-Masmonteil, T. and Marc, I.
DOI: 10.1002/jpen.2380
2022Symptomatic and Asymptomatic Transmission of SARS-CoV-2 in K-12 Schools, British Columbia, Canada April to June 2021
Microbiology Spectrum
Choi, A. and M{\^a}sse, L.C. and Bardwell, S. and Kayda, I. and Zhao, Y. and Xu, Y.X.Z. and Markarian, A. and Coombs, D. and Macdonald, A. and Watts, A.W. and Dhillon, N. and Irvine, M. and O?Reilly, C. and Lavoie, P.M. and Goldfarb, D.M.
DOI: 10.1128/spectrum.00622-22
2022Antibody response to the BNT162b2 SARS-CoV-2 vaccine in paediatric patients with inflammatory bowel disease treated with anti-TNF therapy
Gut
Shire, Z.J. and Reicherz, F. and Lawrence, S. and Sudan, H. and Golding, L. and Majdoubi, A. and Levett, P.N. and Lavoie, P.M. and Jacobson, K.
DOI: 10.1136/gutjnl-2021-326196
2022SARS-CoV-2 seroprevalence among Vancouver public school staff in British Columbia, Canada: A cross-sectional study
BMJ Open
Goldfarb, D.M. and Mâsse, L.C. and Watts, A.W. and Hutchison, S.M. and Muttucomaroe, L. and Bosman, E.S. and Barakauskas, V.E. and Choi, A. and Dhillon, N. and Irvine, M.A. and Reicherz, F. and O'Reilly, C. and Sediqi, S. and Xu, R.Y. and Razzaghian, H.R. and Sadarangani, M. and Coombs, D. and O'Brien, S.F. and Lavoie, P.M.
DOI: 10.1136/bmjopen-2021-057846
2022SARS-CoV-2 seroprevalence among public school staff in Metro Vancouver after the first Omicron wave in British Columbia, Canada
medRxiv
Watts, A.W. and M{\^a}sse, L.C. and Goldfarb, D.M. and Irvine, M.A. and Hutchison, S.M. and Muttucomaroe, L. and Poon, B. and Barakauskas, V.E. and O?Reilly, C. and Bosman, E.S. and Reicherz, F. and Coombs, D. and Pitblado, M. and O?Brien, S.F. and Lavoie, P.M.
DOI: 10.1101/2022.07.04.22277230
2022Polycomb contraction differentially regulates terminal human hematopoietic differentiation programs
BMC Biology
DOI: 10.1186/s12915-022-01315-1
2022Determining the optimal SARS-CoV-2 mRNA vaccine dosing interval for maximum immunogenicity
bioRxiv
Asamoah-Boaheng, M. and Goldfarb, D.M. and Prusinkiewicz, M.A. and Golding, L. and Karim, M.E. and Barakauskas, V. and Wall, N. and Jassem, A.N. and Marquez, A.C. and MacDonald, C. and O'Brien, S.F. and Lavoie, P. and Grunau, B.
DOI: 10.1101/2022.03.01.482592
2022Correlation of SARS-CoV-2 Viral Neutralizing Antibody Titers with Anti-Spike Antibodies and ACE-2 Inhibition among Vaccinated Individuals
Microbiology Spectrum
Grunau, B. and Prusinkiewicz, M. and Asamoah-Boaheng, M. and Golding, L. and Lavoie, P.M. and Petric, M. and Levett, P.N. and Haig, S. and Barakauskas, V. and Karim, M.E. and Jassem, A.N. and Drews, S.J. and Sediqi, S. and Goldfarb, D.M.
DOI: 10.1128/spectrum.01315-22
2022Maternal High-Dose DHA Supplementation and Neurodevelopment at 18–22 Months of Preterm Children
Pediatrics
DOI: 10.1542/peds.2021-055819
2022Effect of Maternal Docosahexaenoic Acid Supplementation on Very Preterm Infant Growth: Secondary Outcome of a Randomized Clinical Trial
Neonatology
Angoa, G. and Pronovost, E. and Ndiaye, A.B.K.T. and Lavoie, P.M. and Lemyre, B. and Mohamed, I. and Simonyan, D. and Qureshi, M. and Afifi, J. and Yusuf, K. and Sériès, T. and Guillot, M. and Piedboeuf, B. and Fraser, W.D. and Nuyt, A.-M. and Mâsse, B. and Lacaze-Masmonteil, T. and Marc, I.
DOI: 10.1159/000524147
2022A Higher Antibody Response Is Generated with a 6-to 7-Week (vs Standard) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Dosing Interval
Clinical Infectious Diseases
Grunau, B. and Asamoah-Boaheng, M. and Lavoie, P.M. and Karim, M.E. and Kirkham, T.L. and Demers, P.A. and Barakauskas, V. and Marquez, A.C. and Jassem, A.N. and O{'}Brien, S.F. and Drews, S.J. and Haig, S. and Cheskes, S. and Goldfarb, D.M.
DOI: 10.1093/cid/ciab938
2022Human complete NFAT1 deficiency causes a triad of joint contractures, osteochondromas, and B-cell malignancy
Blood
Sharma, M. and Fu, M.P. and Lu, H.Y. and Sharma, A.A. and Modi, B.P. and Michalski, C. and Lin, S. and Dalmann, J. and Salman, A. and Del Bel, K.L. and Waqas, M. and Terry, J. and Setiadi, A. and Lavoie, P.M. and Wasserman, W.W. and Mwenifumbo, J. and Kobor, M.S. and Lee, A.F. and Kuchenbauer, F. and Lehman, A. and Cheng, S. and Cooper, A. and Patel, M.S. and Turvey, S.E.
DOI: 10.1182/blood.2022015674
2022Gut microbiome and dietary fibre intake strongly associate with IgG function and maturation following SARS-CoV-2 mRNA vaccination
Gut
Healey, G.R. and Golding, L. and Schick, A. and Majdoubi, A. and Lavoie, P.M. and Vallance, B.A.
DOI: 10.1136/gutjnl-2022-328556
2022Global health systems' data science approach for precision diagnosis of sepsis in early life
The Lancet Infectious Diseases
Iregbu, K. and Dramowski, A. and Milton, R. and Nsutebu, E. and Howie, S.R.C. and Chakraborty, M. and Lavoie, P.M. and Costelloe, C.E. and Ghazal, P.
DOI: 10.1016/S1473-3099(21)00645-9
2022Evaluation of the Performance of a Multiplexed Serological Assay in the Detection of SARS-CoV-2 Infections in a Predominantly Vaccinated Population
Microbiology Spectrum
Asamoah-Boaheng, M. and Goldfarb, D.M. and Barakauskas, V. and Kirkham, T.L. and Demers, P.A. and Ehsanul Karim, M. and Lavoie, P.M. and Marquez, A.C. and Jassem, A.N. and Jenneson, S. and MacDonald, C. and Grunau, B.
DOI: 10.1128/spectrum.01454-21
2022Correlates of Protection Against Respiratory Syncytial Virus Infection in Infancy
Clinical Reviews in Allergy and Immunology
Abu-Raya, B. and Reicherz, F. and Lavoie, P.M.
DOI: 10.1007/s12016-022-08948-8
2022Comparative 6-Month Wild-Type and Delta-Variant Antibody Levels and Surrogate Neutralization for Adults Vaccinated with BNT162b2 versus mRNA-1273
Microbiology Spectrum
Grunau, B. and Golding, L. and Prusinkiewicz, M.A. and Asamoah-Boaheng, M. and Armour, R. and Marquez, A.C. and Jassem, A.N. and Barakauskas, V. and O?Brien, S.F. and Drews, S.J. and Haig, S. and Lavoie, P.M. and Goldfarb, D.M.
DOI: 10.1128/spectrum.02702-21
2022Immunogenicity of Extended mRNA SARS-CoV-2 Vaccine Dosing Intervals
JAMA - Journal of the American Medical Association
Grunau, B. and Goldfarb, D.M. and Asamoah-Boaheng, M. and Golding, L. and Kirkham, T.L. and Demers, P.A. and Lavoie, P.M.
DOI: 10.1001/jama.2021.21921
2022Potential resurgence of respiratory syncytial virus in Canada
CMAJ
Lavoie, P.M. and Reicherz, F. and Solimano, A. and Langley, J.M.
DOI: 10.1503/cmaj.210919
2021Neonatal T Helper 17 Responses Are Skewed Towards an Immunoregulatory Interleukin-22 Phenotype
Frontiers in Immunology
Razzaghian, H.R. and Sharafian, Z. and Sharma, A.A. and Boyce, G.K. and Lee, K. and Da Silva, R. and Orban, P.C. and Sekaly, R.-P. and Ross, C.J. and Lavoie, P.M.
DOI: 10.3389/fimmu.2021.655027
2021Possible résurgence du virus respiratoire syncytial au Canada
CMAJ
Lavoie, P.M. and Reicherz, F. and Solimano, A. and Langley, J.M.
DOI: 10.1503/CMAJ.210919-F
2021Interleukin-37 regulates innate immune signaling in human and mouse colonic organoids
Scientific Reports
Allaire, J.M. and Poon, A. and Crowley, S.M. and Han, X. and Sharafian, Z. and Moore, N. and Stahl, M. and Bressler, B. and Lavoie, P.M. and Jacobson, K. and Li, X. and Vallance, B.A.
DOI: 10.1038/s41598-021-87592-2
2021Docosahexaenoic acid-rich algae oil supplementation on breast milk fatty acid profile of mothers who delivered prematurely: a randomized clinical trial
Scientific Reports
Fougère, H. and Bilodeau, J.-F. and Lavoie, P.M. and Mohamed, I. and Rudkowska, I. and Pronovost, E. and Simonyan, D. and Berthiaume, L. and Guillot, M. and Piedboeuf, B. and Julien, P. and Marc, I.
DOI: 10.1038/s41598-021-01017-8
2021Symptomatic and asymptomatic transmission of SARS-CoV-2 in K-12 schools, British Columbia, April to June 2021
medRxiv
Choi, A. and M{\^a}sse, L.C. and Bardwell, S. and Zhao, Y. and Xu, Y.X.Z. and Markarian, A. and Coombs, D. and Watts, A. and Macdonald, A. and Dhillon, N. and Irvine, M. and O{'}Reilly, C. and Lavoie, P.M. and Goldfarb, D.
DOI: 10.1101/2021.11.15.21266284
2021SARS-CoV-2 seroprevalence among Vancouver public school staff in British Columbia, Canada
medRxiv
Goldfarb, D.M. and M{\^a}sse, L.C. and Watts, A.W. and Hutchison, S.M. and Muttucomaroe, L. and Bosman, E.S. and Barakauskas, V.E. and Choi, A. and Irvine, M.A. and Reicherz, F. and Coombs, D. and O{'}Reilly, C. and Sediqi, S. and Razzaghian, H.R. and Sadarangani, M. and O{'}Brien, S.F. and Lavoie, P.M.
DOI: 10.1101/2021.06.16.21258861
2021A majority of uninfected adults show preexisting antibody reactivity against SARS-CoV-2
JCI Insight
Majdoubi, A. and Michalski, C. and O?Connell, S.E. and Dada, S. and Narpala, S. and Gelinas, J. and Mehta, D. and Cheung, C. and Winkler, D.F.H. and Basappa, M. and Liu, A.C. and Görges, M. and Barakauskas, V.E. and Irvine, M. and Mehalko, J. and Esposito, D. and Sekirov, I. and Jassem, A.N. and Goldfarb, D.M. and Pelech, S. and Douek, D.C. and McDermott, A.B. and Lavoie, P.M.
DOI: 10.1172/jci.insight.146316
2021Antibody Reactivity Against SARS-CoV-2 in Adults from the Vancouver Metropolitan Area, Canada
Majdoubi A and O’Connell SE and Michalski C and Dada S and Narparla S and Gelinas J and Mehta D and Cheung C and Basappa M and Görges M and Barakauska VE and Goldfarb DM and Douek DC and Lavoie P
DOI: 10.2139/ssrn.3708321
10/2020Antibody reactivity to SARS-CoV-2 is common in unexposed adults and infants under 6 months
Majdoubi A and Michalski C and O’Connell SE and Dada S and Narpala S and Gelinas J and Mehta D and Cheung C and Basappa M and Liu AC and Görges M and Barakauskas VE and Mehalko J and Lavoie PM
DOI: 10.1101/2020.10.05.20206664
10/2020The Effect of Massage on the Cardiac Autonomic Nervous System and Markers of Inflammation in Night Shift Workers: a Pilot Randomized Crossover Trial.
International journal of therapeutic massage & bodywork
Fazeli MS and Pourrahmat MM and Massah G and Lee K and Lavoie PM and Fazeli M and Esser A and Collet JP
PubMed: 32922577
08/2020Maternal Immunological Adaptation During Normal Pregnancy
Frontiers in Immunology
Abu-Raya, B. and Michalski, C. and Sadarangani, M. and Lavoie, P.M.
DOI: 10.3389/fimmu.2020.575197
2020The effect of massage on the cardiac autonomic nervous system and markers of inflammation in night shift workers: A pilot randomized crossover trial
International Journal of Therapeutic Massage and Bodywork: Research, Education, and Practice
Fazeli, M.S. and Pourrahmat, M.-M. and Massah, G. and Lee, K. and Lavoie, P.M. and Fazeli, M. and Esser, A. and Collet, J.-P.
DOI: 10.3822/ijtmb.v13i3.501
2020Effect of Low Versus High Tidal-Volume Total Liquid Ventilation on Pulmonary Inflammation
Frontiers in Physiology
Sage, M. and See, W. and Nault, S. and Morin, C. and Michalski, C. and Chabot, B. and Marouan, S. and Lavoie, P.M. and Micheau, P. and Praud, J.-P. and Fortin-Pellerin, ?.
DOI: 10.3389/fphys.2020.00603
2020Maternal Docosahexaenoic Acid Supplementation and Bronchopulmonary Dysplasia in Infants - Reply
JAMA - Journal of the American Medical Association
Marc, I. and Julien, P. and Lavoie, P.M.
DOI: 10.1001/jama.2020.19410
2020Distinct immunity of the newborn: clinical implications
Stiehm's Immune Deficiencies: Inborn Errors of Immunity
DOI: 10.1016/B978-0-12-816768-7.00045-4
2020Whole blood genome-wide transcriptome profiling and metagenomics next-generation sequencing in young infants with suspected sepsis in a low-and middle-income country: A study protocol
Gates Open Research
Lavoie, P.M. and Popescu, C.R. and Tembo, B. and Chifisi, R. and Cavanagh, M.M.M. and Lee, A.-Y. and Chiluzi, B. and Ciccone, E.J. and Tegha, G. and Alonso-Prieto, E. and Claydon, J. and Dunsmuir, D. and Irvine, M. and Dumont, G. and Ansermino, J.M. and Wiens, M.O. and Juliano, J.J. and Kissoon, N. and Mvalo, T. and Lufesi, N. and Chiume-Kayuni, M.
DOI: 10.12688/gatesopenres.13172.2
2020Neonatal sepsis in low-income countries: epidemiology, diagnosis and prevention
Expert Review of Anti-Infective Therapy
Popescu, C.R. and Cavanagh, M.M.M. and Tembo, B. and Chiume, M. and Lufesi, N. and Goldfarb, D.M. and Kissoon, N. and Lavoie, P.M.
DOI: 10.1080/14787210.2020.1732818
2020Rethinking management of neonates at risk of sepsis
The Lancet
Lavoie, P.M. and Popescu, C.R. and Molyneux, E.M. and Wynn, J.L. and Chiume, M. and Keitel, K. and Lufesi, N. and Levine, G.A. and Ansermino, J.M. and Kissoon, N.
DOI: 10.1016/S0140-6736(19)31627-7
2019Genetics of bronchopulmonary dysplasia: When things do not match up, it is only the beginning
Journal of Pediatrics
Bhandari, V. and Gruen, J.R. and Jang, K.L. and Göpel, W. and Hallman, M. and Lavoie, P.M.
DOI: 10.1016/j.jpeds.2019.01.014
2019RAPIDOMICS: rapid genome-wide sequencing in a neonatal intensive care unit—successes and challenges
European Journal of Pediatrics
Elliott, A.M. and du Souich, C. and Lehman, A. and Guella, I. and Evans, D.M. and Candido, T. and Tooman, L. and Armstrong, L. and Clarke, L. and Gibson, W. and Gill, H. and Lavoie, P.M. and Lewis, S. and McKinnon, M.L. and Nikkel, S.M. and Patel, M. and Solimano, A. and Synnes, A. and Ting, J. and van Allen, M. and Christilaw, J. and Farrer, M.J. and Friedman, J.M. and Osiovich, H.
DOI: 10.1007/s00431-019-03399-4
2019Evolution of Training Guidelines for Echocardiography Performed by the Neonatologist: Toward Hemodynamic Consultation
Journal of the American Society of Echocardiography
Hébert, A. and Lavoie, P.M. and Giesinger, R.E. and Ting, J.Y. and Finan, E. and Singh, Y. and de Boode, W. and Kluckow, M. and Mertens, L. and McNamara, P.J.
DOI: 10.1016/j.echo.2019.02.002
2019Congenital lactic acidosis, cerebral cysts and pulmonary hypertension in an infant with FOXRED1 related complex 1 deficiency
Molecular Genetics and Metabolism Reports
Apatean, D. and Rakic, B. and Brunel-Guitton, C. and Hendson, G. and Bai, R. and Sargent, M.A. and Lavoie, P.M. and Patel, M. and Stockler-Ipsiroglu, S.
DOI: 10.1016/j.ymgmr.2019.100472
2019Congenital lactic acidosis, cerebral cysts and pulmonary hypertension in an infant with FOXRED1 related complex I deficiency
Molecular Genetics and Metabolism Reports
Apatean, D. and Rakic, B. and Brunel-Guitton, C. and Hendson, G. and Bai, R. and Sargent, M.A. and Lavoie, P.M. and Patel, M. and Stockler-Ipsiroglu, S.
DOI: 10.1016/j.ymgmr.2018.12.006
2019Predictor variables for post-discharge mortality modelling in infants: A protocol development project
African Health Sciences
Nemetchek, B.R. and Liang, L. and Kissoon, N. and Ansermino, J.M. and Kabakyenga, J. and Lavoie, P.M. and Fowler-Kerry, S. and Wiens, M.O.
DOI: 10.4314/AHS.V18I4.43
2018Predictors of mortality in neonates and infants hospitalized with sepsis or serious infections in developing countries: A systematic review
Frontiers in Pediatrics
(Danny) Liang, L. and Kotadia, N. and English, L. and Kissoon, N. and Mark Ansermino, J. and Kabakyenga, J. and Lavoie, P.M. and Wiens, M.O.
DOI: 10.3389/fped.2018.00277
2018Glucose control and autonomic response during acute stress in youth with type 1 diabetes: A pilot study
Pediatric Diabetes
Guan, L. and Metzger, D.L. and Lavoie, P.M. and Collet, J.-P.
DOI: 10.1111/pedi.12680
2018Differences in DNA methylation of white blood cell types at birth and in adulthood reflect postnatal immune maturation and influence accuracy of cell type prediction
bioRxiv
Jones, M.J. and Dinh, L. and Razzaghian, H.R. and de Goede, O. and MacIsaac, J.L. and Morin, A.M. and Gervin, K. and Ng, R. and Duijts, L. and van Zelm, M.C. and Moll, H.A. and Lyle, R. and Robinson, W.P. and Koestler, D.C. and Felix, J.F. and Lavoie, P.M. and Mostafavi, S. and Kobor, M.S.
DOI: 10.1101/399279
2018Mononuclear Phagocyte System
Fetal and Neonatal Physiology
Pascal M. Lavoie and Ofer Levy
DOI: 10.1016/b978-0-323-35214-7.00125-6
2017Respiratory syncytial virus-neutralizing serum antibody titers in infants following palivizumab prophylaxis with an abbreviated dosing regimen
PLoS ONE
Claydon, J. and Sur, A. and Callejas, A. and Ladd, M. and Kwan, E. and Taylor, R. and Turvey, S.E. and Solimano, A. and Lavoie, P.M. and Marr, N.
DOI: 10.1371/journal.pone.0176152
2017Genome-wide association study of bronchopulmonary dysplasia: A potential role for variants near the CRP gene
Scientific Reports
Mahlman, M. and Karjalainen, M.K. and Huusko, J.M. and Andersson, S. and Kari, M.A. and Tammela, O.K.T. and Sankilampi, U. and Lehtonen, L. and Marttila, R.H. and Bassler, D. and Poets, C.F. and Lacaze-Masmonteil, T. and Danan, C. and Delacourt, C. and Palotie, A. and Muglia, L.J. and Lavoie, P.M. and Hadchouel, A. and Rämet, M. and Hallman, M.
DOI: 10.1038/s41598-017-08977-w
2017A Potential Role for the NOD1 Variant (rs6958571) in Gram-Positive Blood Stream Infection in ELBW Infants
Neonatology
Sampath, V. and Mulrooney, N. and Patel, A.L. and Cohen, J. and Zhang, L. and Garland, J. and Lavoie, P.M. and Dagle, J. and Simpson, P.
DOI: 10.1159/000477433
2017A functional ATG16L1 (T300A) variant is associated with necrotizing enterocolitis in premature infants
Pediatric Research
Sampath, V. and Bhandari, V. and Berger, J. and Merchant, D. and Zhang, L. and Ladd, M. and Menden, H. and Garland, J. and Ambalavanan, N. and Mulrooney, N. and Quasney, M. and Dagle, J. and Lavoie, P.M. and Simpson, P. and Dahmer, M.
DOI: 10.1038/pr.2016.260
2017Why haven't the documented benefits of probiotics on preterm babies led to their wider acceptance and use?
Acta Paediatrica, International Journal of Paediatrics
Popescu, C.R. and Stiemsma, L.T. and Lavoie, P.M.
DOI: 10.1111/apa.13893
2017Multiple Successful Angioembolizations for Refractory Cardiac Failure in a Preterm with Rapidly Involuting Congenital Hemangioma
American Journal of Perinatology Reports
Amitava Sur and Heran Manraj and Pascal Lavoie and Ken Lim and Douglas Courtemanche and Paul Brooks and Susan Albersheim
DOI: 10.1055/s-0035-1570342
01/2016Characterizing the hypomethylated DNA methylation profile of nucleated red blood cells from cord blood
Epigenomics
De Goede, O.M. and Lavoie, P.M. and Robinson, W.P.
DOI: 10.2217/epi-2016-0069
2016Genetics of Bronchopulmonary Dysplasia
Bronchopulmonary Dysplasia
DOI: 10.1007/978-3-319-28486-6_6
2016Cardiac Autonomic Function at Baseline and under Stress and Its Relationship to Circulatory Markers of Inflammation in Obese Compared to Nonobese Children: A Pilot Study
Hormone Research in Paediatrics
Hursh, B.E. and Fazeli, M.S. and Wang, S. and Marchant, E.A. and Woo, P. and Elango, R. and Lavoie, P.M. and Chanoine, J.-P. and Collet, J.-P.
DOI: 10.1159/000445685
2016Editor’s Focus
Pediatric Research
Elizabeth A. Marchant and Bernard Kan and Ashish A. Sharma and Alice van Zanten and Tobias R. Kollmann and Rollin Brant and Pascal M. Lavoie
DOI: 10.1038/pr.2015.171
10/2015Malaria in immigrant and traveler children: Clinical presentation and risk factors for complications
Journal of Pediatric Infectious Diseases
Pascal Lavoie and Monique Robert and Marc Lebel and Dorothy Moore and Selim Rashed and Ana Carceller
DOI: 10.1055/s-0035-1557058
07/2015Impaired NLRP3 inflammasome activity during fetal development regulates IL-1ß production in human monocytes
European Journal of Immunology
Sharma, A.A. and Jen, R. and Kan, B. and Sharma, A. and Marchant, E. and Tang, A. and Gadawski, I. and Senger, C. and Skoll, A. and Turvey, S.E. and Sly, L.M. and Côté, H.C.F. and Lavoie, P.M.
DOI: 10.1002/eji.201444707
2015Catecholamine-resistant hypotension and myocardial performance following patent ductus arteriosus ligation
Journal of Perinatology
Noori, S. and McNamara, P. and Jain, A. and Lavoie, P.M. and Wickremasinghe, A. and Merritt, T.A. and Solomon, T. and Sekar, K. and Attridge, J.T. and Swanson, J.R. and Gillam-Krakauer, M. and Reese, J. and Poindexter, B.B. and Brook, M. and Auchus, R.J. and Clyman, R.I. and Matthews, S. and Chomic, R. and Brown, S.C. and Kuhn, M. and El-Khuffash, A. and Luc, J. and McCoy, M. and Corff, K. and Claydon, J. and Lusney, N. and Finlay, K. and Blackman, A.E. and Law-Beller, A. and Wilson, L.D.
DOI: 10.1038/jp.2014.151
2015A randomized controlled trial of the use of oral glucose with or without gentle facilitated tucking of infants during neonatal echocardiography
PLoS ONE
Lavoie, P.M. and Stritzke, A. and Ting, J. and Jabr, M. and Jain, A. and Kwan, E. and Chakkarapani, E. and Brooks, P. and Brant, R. and McNamara, P.J. and Holsti Holsti, L.
DOI: 10.1371/journal.pone.0141015
2015The Crohn's disease-associated polymorphism in ATG16L1 (rs2241880) reduces SHIP gene expression and activity in human subjects
Genes and Immunity
Ngoh, E.N. and Brugger, H.K. and Monajemi, M. and Menzies, S.C. and Hirschfeld, A.F. and Del Bel, K.L. and Jacobson, K. and Lavoie, P.M. and Turvey, S.E. and Sly, L.M.
DOI: 10.1038/gene.2015.30
2015Polymorphisms of the gene encoding Kit ligand are associated with bronchopulmonary dysplasia
Pediatric Pulmonology
Huusko, J.M. and Mahlman, M. and Karjalainen, M.K. and Kaukola, T. and Haataja, R. and Marttila, R. and Toldi, G. and Szabó, M. and Kingsmore, S.F. and Rämet, M. and Lavoie, P.M. and Hallman, M.
DOI: 10.1002/ppul.23018
2015Genes Encoding Vascular Endothelial Growth Factor A (VEGF-A) and VEGF Receptor 2 (VEGFR-2) and Risk for Bronchopulmonary Dysplasia on behalf of the Gen-BPD Study Group
Neonatology
Mahlman, M. and Huusko, J.M. and Karjalainen, M.K. and Kaukola, T. and Marttila, R. and Ojaniemi, M. and Haataja, R. and Lavoie, P.M. and Rämet, M. and Hallman, M.
DOI: 10.1159/000381279
2015Cerebral Palsy and Polymorphism of the Chemokine CCL18 in Very Preterm Children
Neonatology
Kallankari, H. and Huusko, J.M. and Kaukola, T. and Ojaniemi, M. and Mahlman, M. and Marttila, R. and Kingsmore, S.F. and Haataja, L. and Lavoie, P.M. and Synnes, A. and Hallman, M.
DOI: 10.1159/000430765
2015Oral glucose during targeted neonatal echocardiography: Is it useful?
Archives of Disease in Childhood: Fetal and Neonatal Edition
Lavoie, P.M. and Stritzke, A. and Ting, J. and Jabr, M. and Jain, A. and Kwan, E. and Chakkarapani, E. and Brooks, P. and Brant, R. and McNamara, P.J. and Holsti, L.
DOI: 10.1136/archdischild-2015-308191
2015Nucleated red blood cells impact DNA methylation and expression analyses of cord blood hematopoietic cells
Clinical Epigenetics
de Goede, O.M. and Razzaghian, H.R. and Price, E.M. and Jones, M.J. and Kobor, M.S. and Robinson, W.P. and Lavoie, P.M.
DOI: 10.1186/s13148-015-0129-6
2015Assessment of genetic associations between common single nucleotide polymorphisms in RIG-I-like receptor and IL-4 signaling genes and severe respiratory syncytial virus infection in children: A candidate gene case-control study
PLoS ONE
Marr, N. and Hirschfeld, A.F. and Lam, A. and Wang, S. and Lavoie, P.M. and Turvey, S.E.
DOI: 10.1371/journal.pone.0100269
2014A study of genes encoding cytokines (IL6, IL10, TNF), cytokine receptors (IL6R, IL6ST), and glucocorticoid receptor (NR3C1) and susceptibility to bronchopulmonary dysplasia
BMC Medical Genetics
Huusko, J.M. and Karjalainen, M.K. and Mahlman, M. and Haataja, R. and Kari, M.A. and Andersson, S. and Toldi, G. and Tammela, O. and Rämet, M. and Lavoie, P.M. and Hallman, M. and Janér, C. and Kari, A. and Ketola, I. and Sankilampi, U. and Marttila, R. and Lehtonen, L. and Lacaze-Masmonteil, T.
DOI: 10.1186/s12881-014-0120-7
2014Omega-3 long-chain polyunsaturated fatty acids for extremely preterm infants: A systematic review
Pediatrics
Zhang, P. and Lavoie, P.M. and Lacaze-Masmonteil, T. and Rhainds, M. and Marc, I.
DOI: 10.1542/peds.2014-0459
2014Hierarchical maturation of innate immune defences in very preterm neonates
Neonatology
Sharma, A.A. and Jen, R. and Brant, R. and Ladd, M. and Huang, Q. and Skoll, A. and Senger, C. and Turvey, S.E. and Marr, N. and Lavoie, P.M.
DOI: 10.1159/000358550
2014Attenuation of respiratory syncytial virus-induced and RIG-I-dependent type I IFN responses in human neonates and very young children
Journal of Immunology
Marr, N. and Wang, T.-I. and Kam, S.H.Y. and Hu, Y.S. and Sharma, A.A. and Lam, A. and Markowski, J. and Solimano, A. and Lavoie, P.M. and Turvey, S.E.
DOI: 10.4049/jimmunol.1302007
2014Surgical site infections in infants admitted to the neonatal intensive care unit
Journal of Pediatric Surgery
Segal, I. and Kang, C. and Albersheim, S.G. and Skarsgard, E.D. and Lavoie, P.M.
DOI: 10.1016/j.jpedsurg.2013.08.001
2014Preferential cephalic redistribution of left ventricular cardiac output during therapeutic hypothermia for perinatal hypoxic-ischemic encephalopathy
Journal of Pediatrics
Hochwald, O. and Jabr, M. and Osiovich, H. and Miller, S.P. and McNamara, P.J. and Lavoie, P.M.
DOI: 10.1016/j.jpeds.2014.01.028
2014Hypotension following patent ductus arteriosus ligation: The role of adrenal hormones
Journal of Pediatrics
Clyman, R.I. and Wickremasinghe, A. and Merritt, T.A. and Solomon, T. and McNamara, P. and Jain, A. and Singh, J. and Chu, A. and Noori, S. and Sekar, K. and Lavoie, P.M. and Attridge, J.T. and Swanson, J.R. and Gillam-Krakauer, M. and Reese, J. and Demauro, S. and Poindexter, B. and Aucott, S. and Satpute, M. and Fernandez, E. and Auchus, R.J.
DOI: 10.1016/j.jpeds.2014.01.058
2014Response to Comment on "helios+ and helios- cells coexist within the natural FOXP31 T regulatory cell subset in humans"
Journal of Immunology
MacDonald, K.G. and Han, J.M. and Himmel, M.E. and Huang, Q. and Kan, B. and Campbell, A.I.M. and Lavoie, P.M. and Levings, M.K.
DOI: 10.4049/jimmunol.1390019
2013Neonatal sepsis due to coagulase-negative staphylococci
Clinical and Developmental Immunology
Marchant, E.A. and Boyce, G.K. and Sadarangani, M. and Lavoie, P.M.
DOI: 10.1155/2013/586076
2013Functional genetic variation in NFKBIA and susceptibility to childhood asthma, bronchiolitis, and bronchopulmonary dysplasia
Journal of Immunology
Ali, S. and Hirschfeld, A.F. and Mayer, M.L. and Fortuno III, E.S. and Corbett, N. and Kaplan, M. and Wang, S. and Schneiderman, J. and Fjell, C.D. and Yan, J. and Akhabir, L. and Aminuddin, F. and Marr, N. and Lacaze-Masmonteil, T. and Hegele, R.G. and Becker, A. and Chan-Yeung, M. and Hancock, R.E.W. and Kollmann, T.R. and Daley, D. and Sandford, A.J. and Lavoie, P.M. and Turvey, S.E.
DOI: 10.4049/jimmunol.1201015
2013Neonatal Pain-Related Stress and NFKBIA Genotype Are Associated with Altered Cortisol Levels in Preterm Boys at School Age
PLoS ONE
Grunau, R.E. and Cepeda, I.L. and Chau, C.M.Y. and Brummelte, S. and Weinberg, J. and Lavoie, P.M. and Ladd, M. and Hirschfeld, A.F. and Russell, E. and Koren, G. and Van Uum, S. and Brant, R. and Turvey, S.E.
DOI: 10.1371/journal.pone.0073926
2013Influence of common non-synonymous toll-like receptor 4 polymorphisms on bronchopulmonary dysplasia and prematurity in human infants
PLoS ONE
Lavoie, P.M. and Ladd, M. and Hirschfeld, A.F. and Huusko, J. and Mahlman, M. and Speert, D.P. and Hallman, M. and Lacaze-Masmonteil, T. and Turvey, S.E.
DOI: 10.1371/journal.pone.0031351
2012Inflammasome-mediated IL-1ß production in humans with cystic fibrosis
PLoS ONE
Tang, A. and Sharma, A. and Jen, R. and Hirschfeld, A.F. and Chilvers, M.A. and Lavoie, P.M. and Turvey, S.E.
DOI: 10.1371/journal.pone.0037689
2012The developing human preterm neonatal immune system: A case for more research in this area
Clinical Immunology
Sharma, A.A. and Jen, R. and Butler, A. and Lavoie, P.M.
DOI: 10.1016/j.clim.2012.08.006
2012Ex vivo purification and characterization of human invariant natural killer T cells
Journal of Immunological Methods
Sharma, A.A. and Chew, L. and Ladd, M. and Jen, R. and Lavoie, P.M.
DOI: 10.1016/j.jim.2011.08.002
2011Early inflammation in the absence of overt infection in preterm neonates exposed to intensive care
Cytokine
Chang, B.A. and Huang, Q. and Quan, J. and Chau, V. and Ladd, M. and Kwan, E. and McFadden, D.E. and Lacaze-Masmonteil, T. and Miller, S.P. and Lavoie, P.M.
DOI: 10.1016/j.cyto.2011.08.028
2011Constitutive Expression of CD25 on the Surface of Neonatal (invariant) Natural Killer T Cells Primes Them to Proliferate with Lower Antigenic Stimulation
Clinical Immunology
Ashish Sharma and Mihoko Whalen and Qing Huang and Adele Wang and Lixin Xu and Indira Genowati and Meghan Levings and Pascal Lavoie
DOI: 10.1016/j.clim.2010.03.151
01/2010Genetics of bronchopulmonary dysplasia in the age of genomics
Current Opinion in Pediatrics
Lavoie, P.M. and Dubé, M.-P.
DOI: 10.1097/MOP.0b013e328336eb85
2010Ontogeny of toll-like receptor mediated cytokine responses of human blood mononuclear cells
PLoS ONE
Corbett, N.P. and Blimkie, D. and Ho, K.C. and Cai, B. and Sutherland, D.P. and Kallos, A. and Crabtree, J. and Rein-Weston, A. and Lavoie, P. and Turvey, S.E. and Hawkins, N.R. and Self, S.G. and Wilson, C.B. and Hajjar, A.M. and Fortuno, E.S. and Kollmann, T.R.
DOI: 10.1371/journal.pone.0015041
2010Do neonatologists limit parental decision-making authority? A Canadian perspective
Early Human Development
Albersheim, S.G. and Lavoie, P.M. and Keidar, Y.D.
DOI: 10.1016/j.earlhumdev.2010.09.007
2010Natural killer T cells constitutively expressing the interleukin-2 receptor a chain early in life are primed to respond to lower antigenic stimulation
Immunology
Ladd, M. and Sharma, A. and Huang, Q. and Wang, A.Y. and Xu, L. and Genowati, I. and Levings, M.K. and Lavoie, P.M.
DOI: 10.1111/j.1365-2567.2010.03304.x
2010Incidence of septicemia immediately after elective gastrointestinal contrast procedures in infants: a cohort study
Journal of Pediatric Surgery
Abu-Sharar, Z. and Robinson, A. and Lavoie, P.M.
DOI: 10.1016/j.jpedsurg.2009.07.023
2010Profound lack of interleukin (IL)-12/IL-23p40 in neonates born early in gestation is associated with an increased risk of sepsis
Journal of Infectious Diseases
Lavoie, P.M. and Huang, Q. and Jolette, E. and Whalen, M. and Nuyt, A.M. and Audibert, F. and Speert, D.P. and Lacaze-Masmonteil, T. and Soudeyns, H. and Kollmann, T.R.
DOI: 10.1086/657143
2010Inflammatory response in preterm infants is induced early in life by oxygen and modulated by total parenteral nutrition
Pediatric Research
Lavoie, P.M. and Lavoie, J.-C. and Watson, C. and Rouleau, T. and Chang, B.A. and Chessex, P.
DOI: 10.1203/PDR.0b013e3181eb2f18
2010To the editor
Pediatrics
Lavoie, P.M. and Brant, R.
DOI: 10.1542/peds.2008-3324
2009Neonatal innate TLR-mediated responses are distinct from those of adults
Journal of Immunology
Kollmann, T.R. and Crabtree, J. and Rein-Weston, A. and Blimkie, D. and Thommai, F. and Wang, X.Y. and Lavoie, P.M. and Furlong, J. and Fortuno III, E.S. and Hajjar, A.M. and Hawkins, N.R. and Self, S.G. and Wilson, C.B.
DOI: 10.4049/jimmunol.0901481
2009Earlier initiation of enteral nutrition is associated with lower risk of late-onset bacteremia only in most mature very low birth weight infants
Journal of Perinatology
Lavoie, P.M.
DOI: 10.1038/jp.2009.8
2009Heritability of bronchopulmonary dysplasia, defined according to the consensus statement of the national institutes of health
Pediatrics
Lavoie, P.M. and Pham, C. and Jang, K.L.
DOI: 10.1542/peds.2007-2313
2008Gastrointestinal presentation of relative adrenal insufficiency in a sick preterm neonate
American Journal of Perinatology
Lavoie, P.M. and Pelligra, G. and Lupton, B. and Osiovich, H.
DOI: 10.1055/s-2007-986694
2007Attitudes of Canadian Neonatologists in Delivery Room Resuscitation of Newborns at Threshold of Viability
Journal of Obstetrics and Gynaecology Canada
Lavoie, P.M. and Keidar, Y. and Albersheim, S.
DOI: 10.1016/S1701-2163(16)32599-3
2007Delayed expansion of a restricted T cell repertoire by low-density TCR ligands
International Immunology
Lavoie, P.M. and Dumont, A.R. and McGrath, H. and Kernaleguen, A.-E. and Sékaly, R.-P.
DOI: 10.1093/intimm/dxh273
2005Lead poisoning from "lead-free" paint
CMAJ
Lavoie, P.M. and Bailey, B.
DOI: 10.1503/cmaj.1031524
2004Quantitative relationship between MHC class II-superantigen complexes and the balance of T cell activation versus death
Journal of Immunology
Lavoie, P.M. and McGrath, H. and Shoukry, N.H. and Cazenave, P.-A. and Sékaly, R.-A. and Thibodeau, J.
DOI: 10.4049/jimmunol.166.12.7229
2001Superantigen presenting capacity of human astrocytes
Journal of Neuroimmunology
Hassan-Zahraee, M. and Ladiwala, U. and Lavoie, P.M. and McCrea, E. and Sekaly, R.P. and Owens, T. and Antel, J.P.
DOI: 10.1016/S0165-5728(99)00174-5
2000Role of the T cell receptor a chain in stabilizing TCR-superantigen- MHC class II complexes
Immunity
Andersen, P.S. and Lavoie, P.M. and Sékaly, R.-P. and Churchill, H. and Kranz, D.M. and Schlievert, P.M. and Karjalainen, K. and Mariuzza, R.A.
DOI: 10.1016/S1074-7613(00)80047-3
1999Understanding the mechanism of action of bacterial superantigens from a decade of research
Immunological Reviews
Lavoie, P.M. and Thibodeau, J. and Erard, F. and Sékaly, R.-P.
DOI: 10.1111/j.1600-065X.1999.tb01297.x
1999L'infection par le VIH : importance des facteurs de l'hôte.
médecine/sciences
P Champagne and PM Lavoie and RP Sékaly and A Yachou
DOI: 10.4267/10608/1001
1998Conserved structural features between HLA-DOß and -DRß
Molecular Immunology
Thibodeau, J. and Lavoie, P.M. and Samaan, A. and Corre, J.-P. and Sékaly, R.-P. and Cazenave, P.-A.
DOI: 10.1016/S0161-5890(98)00061-3
1998Host factors in HIV infection,L'INFECTION PAR LE VIH: IMPORTANCE DES FACTEURS DE L'HOTE
Medecine/Sciences
Champagne, P. and Lavoie, P.M. and Sékaly, R.-P. and Yachou, A.
1998A mutational analysis of the binding of staphylococcal enterotoxins B and C3 to the T cell receptor ß chain and major histocompatibility complex class II
Journal of Experimental Medicine
Leder, L. and Llera, A. and Lavoie, P.M. and Lebedeva, M.I. and Li, H. and Sékaly, R.-P. and Bohach, G.A. and Gahr, P.J. and Schlievert, P.M. and Karjalainen, K. and Mariuzza, R.A.
DOI: 10.1084/jem.187.6.823
1998Selective binding of bacterial toxins to major histocompatibility complex class II-expressing cells is controlled by invariant chain and HLA-DM
Proceedings of the National Academy of Sciences of the United States of America
Lavoie, P.M. and Thibodeau, J. and Cloutier, I. and Busch, R. and Sékaly, R.-P.
DOI: 10.1073/pnas.94.13.6892
1997Molecular Characterization and Role in T Cell Activation of Staphylococcal Enterotoxin a Binding to the HLA-DR a-Chain
Journal of Immunology
Thibodeau, J. and Dohlsten, M. and Cloutier, I. and Lavoie, P.M. and Bjork, P. and Michel, F. and Léveillé, C. and Mourad, W. and Kalland, T. and Sékaly, R.-P.
1997'Bazinc' instinct: How SEA attracts MCH class II molecules
Research in Immunology
Thibodeau, J. and Lavoie, P.M. and Cazenave, P.-A.
DOI: 10.1016/S0923-2494(97)80864-4
1997Molecular characterization and role in T cell activation of staphylococcal enterotoxin A binding to the HLA-DR alpha-chain.
The Journal of Immunology
1997MHC class II-dependent peptide antigen versus superantigen presentation to T cells
Human Immunology
Shoukry, N.H. and Lavoie, P.M. and Thibodeau, J. and D'Souza, S. and Sekaly, R.P.
DOI: 10.1016/S0198-8859(97)00074-8
1997Subsets of HLA-DR1 molecules defined by SEB and TSST-1 binding
Science
Thibodeau, J. and Cloutier, I. and Lavoie, P.M. and Labrecque, N. and Mourad, W. and Jardetzky, T. and Sékaly, R.-P.
DOI: 10.1126/science.7997881
1994 - Research
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Innate and adaptive immune defences in human neonates across development
This research aims to study of the development of the immune system in humans before and shortly at birth. We create and employ miniaturized immunoassays to characterize immunological responses in infants from 24 weeks of gestation at birth, until the first year. We employ molecular and cell-based approaches such as systems level transcriptomics and single-cell flow cytometry to understand how immune phenotypes link to health outcomes in these populations. Our studies in this area currently focus on neonatal sepsis, innate immunity, CD4 T cell differentiation, COVID-19 and respiratory syncytial virus antibody responses.Anti-inflamatory treatment for bronchopulmonary dysplasia
We are one of the leading centres of the CIHR-funded MOBYDICK Canadian multi-centre randomized clinical trial to determine whether maternal omega-3 supplementation effectively reduces bronchopulmonary dysplasia in very preterm infants.Serological responses to COVID-19
With the recent SARS-CoV-2 pandemic, we moved into projects aiming at understanding antibody immunity against this virus at the population level, in infants but also healthy adults. Check out our ongoing study by visiting the link below:
https://www.bcchr.ca/COVIDatschoolsGrantsCanadian COVID-19 Immunity Task Force (Public Health Agency of Canada) - “Tracking COVID to Inform Interventions and Help Make our Schools Safer” (2021)
Peter Wall Institute for Advanced Studies - "VitalVideo: Early identification of critically ill infants using video monitoring" (2019-2021)
Gates Foundation - Global Grand Challenges - "Improving Diagnosis of Sepsis in Young Infants in Africa: Are We Using Antibiotics Appropriately?" (2019-2020)
Women's Health Research Institute - "BC Women's Preemie Biobank" (2019)
Healthy Starts Catalyst Grant - "Single-cell analysis of immune cells during fetal ontogeny" (2018-2019)
BCCHRI Healthy Starts Theme Catalyst Grant - "An in vitro neonatal gut model to understand necrotizing enterocolitis" (2020-2021)
National Institutes of Health - "Omics analysis of innate immunity in preterm infants in response to natural flu infection and influenza vaccination" (2018-2020)
CIHR Project Grant - "Metabolic regulation of immune defenses in newborns" (2019-2024)
Grand Challenges Canada - "Improving the early diagnosis of neonatal sepsis in Malawi" (2017-2019)
CIHR Operating Grant – "Maternal Omega-3 supplementation to reduce Bronchopulmonary Dysplasia in very Preterm Infants" (2014-2019 - extended until 2021)
Honours & AwardsBC Children's Hospital Investigator Grant Award Program (IGAP) - 2014 - 2023
CFRI Clinician-Scientist Award – 2008-2013
Michael Smith Foundation for Health Research – Career Investigator Award – 2011-2019
Research Group MembersCheuk Au, research assistant
Lisa-Marie Candeias, Administrative Assistant
Blandine Dang, Ph. D. student
Eva Jensen, Trainee
Rujun Kang, Research Assistant/Lab Technician Level 4
Leana Lavoie, Lab Assistant
Alexanne Lavoie
Pearl Park, Summer student
Constantin Popescu, Doctoral Student , Doctoral Student
Lindsay Richter, Research Manager
Jacob Shew, Summer Student
Marina Vineta, Graduate Research Assistant
Allison Watts
How are COVID-19 mRNA vaccines linked to the gut microbiome and dietary fibre intake?
Dr. Genelle Lunken recently led a study looking at COVID-19 vaccination and its association with the gut microbiome and dietary fibre intake.
