- Overview
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Despite much effort, we know little about how the healthy child is protected from infectious disease, and even less about why some children develop inflammatory disorders. Why do some healthy children succumb to overwhelming bacterial infection, while others either survive infection or do not become infected at all? Why do some children suffer crippling juvenile arthritis or life-threatening asthma?
My research program is translational, interdisciplinary and unique in its focus on understanding the role of innate immunity in infectious and inflammatory diseases of childhood. Starting with a population of children with a defined infectious or inflammatory disease phenotype (e.g., undue susceptibility to infection, juvenile idiopathic arthritis, asthma), I aim to determine the underlying cellular, molecular and genetic abnormalities responsible for the disease through detailed immunological, genomic and proteomic analysis. The new knowledge generated by this approach will aid diagnosis, elucidate mechanisms of disease pathogenesis and, ultimately, identify novel targets for anti-inflammatory and anti-infectious therapeutic agents.
- Publications
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Early-life cytomegalovirus infection is associated with changes in the intestinal microbiota and increased risk of atopy
Hind Sbihi and Karen Simmons and Malcolm Sears and Theo Moraes and Allen Becker and Piush Mandhane and Padmaja Subbarao and Darlene Dai and B. Brett Finlay and Stuart Turvey and Soren Gantt
DOI: 10.22541/au.170664669.98960899/v1
01/2024Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 (Genome Medicine, (2023), 15, 1, (22), 10.1186/s13073-023-01173-8)
Genome Medicine
DOI: 10.1186/s13073-023-01278-0
2024Gain-of-function MARK4 variant associates with pediatric neurodevelopmental disorder and dysmorphism
Human Genetics and Genomics Advances
DOI: 10.1016/j.xhgg.2023.100259
2024Erratum: Correction to: Examining psychosocial pathways to explain the link between breastfeeding practices and child behaviour in a longitudinal cohort (BMC public health (2024) 24 1 DOI: 10.1186/s12889-024-17994-0)
BMC public health
DOI: 10.1186/s12889-024-19043-2
2024Comprehensive whole-genome sequence analyses provide insights into the genomic architecture of cerebral palsy
Nature Genetics
DOI: 10.1038/s41588-024-01686-x
2024Association of Human Milk Fatty Acid Composition with Maternal Cardiometabolic Diseases: An Exploratory Prospective Cohort Study
Breastfeeding Medicine
DOI: 10.1089/bfm.2024.0019
2024Persistent DNA Methylation Changes across the First Year of Life and Prenatal NO2 Exposure in a Canadian Prospective Birth Study
Environmental Health Perspectives
DOI: 10.1289/EHP13034
2024Naturally occurring splice variants dissect the functional domains of BHC80 and emphasize the need for RNA analysis
American Journal of Medical Genetics, Part A
DOI: 10.1002/ajmg.a.63548
2024Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry
eLife
DOI: 10.7554/eLife.93260
2024MAGinator enables accurate profiling of de novo MAGs with strain-level phylogenies
Nature Communications
DOI: 10.1038/s41467-024-49958-8
2024Impact analysis of infant antibiotic exposure on the burden of asthma: a simulation modeling study
medRxiv
DOI: 10.1101/2024.07.19.24310721
2024Human milk oligosaccharides are associated with maternal genetics and respiratory health of human milk-fed children
Nature Communications
DOI: 10.1038/s41467-024-51743-6
2024Consistent cord blood DNA methylation signatures of gestational age between South Asian and white European cohorts
Clinical Epigenetics
DOI: 10.1186/s13148-024-01684-0
2024Stress and anxiety during pregnancy and length of gestation: a federated study using data from five Canadian and European birth cohorts
European Journal of Epidemiology
DOI: 10.1007/s10654-024-01126-4
2024Microbial colonization programs are structured by breastfeeding and guide healthy respiratory development
Cell
DOI: 10.1016/j.cell.2024.07.022
2024Early prediction of pediatric asthma in the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort using machine learning
Pediatric Research
DOI: 10.1038/s41390-023-02988-2
2024Divergent maturational patterns of the infant bacterial and fungal gut microbiome in the first year of life are associated with inter-kingdom community dynamics and infant nutrition
Microbiome
DOI: 10.1186/s40168-023-01735-3
2024A Murine Model of Maternal Micronutrient Deficiencies and Gut Inflammatory Host-microbe Interactions in the Offspring
Cellular and Molecular Gastroenterology and Hepatology
DOI: 10.1016/j.jcmgh.2024.01.018
2024A decade of progress in juvenile idiopathic arthritis treatments and outcomes in Canada: Results from ReACCh-Out and the CAPRI registry
Rheumatology (United Kingdom)
DOI: 10.1093/rheumatology/kead560
2024Sensory neurons promote immune homeostasis in the lung
Cell
DOI: 10.1016/j.cell.2023.11.027
2024Multimodal machine learning for modeling infant head circumference, mothers’ milk composition, and their shared environment
Scientific Reports
DOI: 10.1038/s41598-024-52323-w
2024Human germline gain-of-function in STAT6: from severe allergic disease to lymphoma and beyond
Trends in Immunology
DOI: 10.1016/j.it.2023.12.003
2024Genome-wide enhancer-associated tandem repeats are expanded in cardiomyopathy
eBioMedicine
DOI: 10.1016/j.ebiom.2024.105027
2024Development and Validation of an Asthma Policy Model for Canada:Lifetime Exposures and Asthma outcomes Projection (LEAP)
medRxiv
DOI: 10.1101/2024.03.11.24304122
2024Association between Maternal Perinatal Stress and Depression on Infant DNA Methylation in the First Year of Life
Research Square
DOI: 10.21203/rs.3.rs-3962429/v1
2024Pre-labor and post-labor cesarean delivery and early childhood adiposity in the Canadian Healthy Infant Longitudinal Development (CHILD) Cohort Study
International Journal of Obesity
DOI: 10.1038/s41366-024-01480-z
2024Organophosphate ester flame retardants and plasticizers in house dust and mental health outcomes among Canadian mothers: A nested prospective cohort study in CHILD
Environmental Research
DOI: 10.1016/j.envres.2023.117451
2024Maternal smoking during pregnancy increases the risk of gut microbiome-associated childhood overweight and obesity
Gut Microbes
DOI: 10.1080/19490976.2024.2323234
2024Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection
Human Genetics and Genomics Advances
DOI: 10.1016/j.xhgg.2024.100300
2024Examining psychosocial pathways to explain the link between breastfeeding practices and child behaviour in a longitudinal cohort
BMC Public Health
DOI: 10.1186/s12889-024-17994-0
2024Antibiotics taken within the first year of life are linked to infant gut microbiome disruption and elevated atopic dermatitis risk
Journal of Allergy and Clinical Immunology
DOI: 10.1016/j.jaci.2024.03.025
2024Women in Canada are consuming above the upper intake level of folic acid but few are meeting dietary choline recommendations in the second trimester of pregnancy: data from the CHILD cohort study
Applied Physiology, Nutrition and Metabolism
DOI: 10.1139/apnm-2023-0258
2024The use of prescription medications and non-prescription medications during lactation in a prospective Canadian cohort study
International Breastfeeding Journal
DOI: 10.1186/s13006-024-00628-x
2024Expanding the molecular and phenotypic spectrum of CTLA-4 insufficiency
Pediatric Allergy and Immunology
DOI: 10.1111/pai.14077
2024A multimorphic variant in ThPOK causes a novel human disease characterized by T cell abnormalities, immunodysregulation, allergy, and fibrosis
medRxiv
DOI: 10.1101/2024.06.26.24309360
2024Should “primary immune disorder” replace “inborn error of immunity”? Names matter, but there is room for both
Journal of Allergy and Clinical Immunology
DOI: 10.1016/j.jaci.2024.04.007
2024Infant use of acid-suppressant medication, C. difficile colonization, and childhood body mass index and asthma in a Canadian cohort
Research Square
DOI: 10.21203/rs.3.rs-4488058/v1
2024Inborn errors of immunity in adulthood
Allergy, Asthma and Clinical Immunology
DOI: 10.1186/s13223-023-00862-8
2024Higher COVID-19 pneumonia risk associated with anti-IFN-a than with anti-IFN-¿ auto-Abs in children
Journal of Experimental Medicine
DOI: 10.1084/jem.20231353
2024Finding the balance: The influence of movement behaviours on childhood behaviour problems
Mental Health and Physical Activity
DOI: 10.1016/j.mhpa.2024.100593
2024Human germline heterozygous gain-of-functionSTAT6variants cause severe allergic disease
OpenAlex
DOI: 10.60692/7qktq-9ne80
03/2023A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency
Science Immunology
DOI: 10.1126/sciimmunol.ade7953
2023The Relationship Between Diet, Gut Microbiota, and Serum Metabolome of South Asian Infants at 1 Year
Journal of Nutrition
DOI: 10.1016/j.tjnut.2022.12.016
2023The maternal prenatal and offspring early-life gut microbiome of childhood asthma phenotypes
Allergy: European Journal of Allergy and Clinical Immunology
Lee-Sarwar, K.A. and Chen, Y.-C. and Chen, Y.Y. and Kozyrskyj, A. and Mandhane, P.J. and Turvey, S.E. and Subbarao, P. and Bisgaard, H. and Stokholm, J. and Chawes, B. and S?rensen, S.J. and Kelly, R. and Lasky-Su, J. and Zeiger, R.S. and O{'}Connor, G.T. and Sandel, M.T. and Bacharier, L.B. and Beigelman, A. and Carey, V. and Harshfield, B.J. and Laranjo, N. and Gold, D.R. and Weiss, S. and Litonjua, A.A.
DOI: 10.1111/all.15516
2023Predictors of SARS-CoV-2 anti-Spike IgG antibody levels following two COVID-19 vaccine doses among children and adults in the Canadian CHILD Cohort
medRxiv
DOI: 10.1101/2023.09.06.23294696
2023Maturational patterns of the infant gut mycobiome are associated with early-life body mass index
Cell Reports Medicine
Gutierrez, M.W. and Mercer, E.M. and Moossavi, S. and Laforest-Lapointe, I. and Reyna, M.E. and Becker, A.B. and Simons, E. and Mandhane, P.J. and Turvey, S.E. and Moraes, T.J. and Sears, M.R. and Subbarao, P. and Azad, M.B. and Arrieta, M.-C.
DOI: 10.1016/j.xcrm.2023.100928
2023Early sex-dependent differences in metabolic profiles of overweight and adiposity in young children: a cross-sectional analysis
BMC Medicine
DOI: 10.1186/s12916-023-02886-8
2023Breastfeeding enrichment of B. longum subsp. infantis mitigates the effect of antibiotics on the microbiota and childhood asthma risk
Med
Dai, D.L.Y. and Petersen, C. and Hoskinson, C. and Del Bel, K.L. and Becker, A.B. and Moraes, T.J. and Mandhane, P.J. and Finlay, B.B. and Simons, E. and Kozyrskyj, A.L. and Patrick, D.M. and Subbarao, P. and Bode, L. and Azad, M.B. and Turvey, S.E.
DOI: 10.1016/j.medj.2022.12.002
2023Autoantibodies against type I IFNs in humans with alternative NF-¿B pathway deficiency
Nature
DOI: 10.1038/s41586-023-06717-x
2023Association of COVID-19 Government-Instituted Mask Mandates with Incidence of Mask Use among Children in Alberta, Canada
JAMA Network Open
DOI: 10.1001/jamanetworkopen.2023.17358
2023Association between gas stove use and childhood asthma in the Canadian CHILD Cohort Study
Canadian Journal of Public Health
DOI: 10.17269/s41997-023-00779-0
2023Natural Green Spaces, Sensitization to Allergens, and the Role of Gut Microbiota during Infancy
mSystems
DOI: 10.1128/msystems.01190-22
2023Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children
Science
Lee, D. and Le Pen, J. and Yatim, A. and Dong, B. and Aquino, Y. and Ogishi, M. and Pescarmona, R. and Talouarn, E. and Rinchai, D. and Zhang, P. and Perret, M. and Liu, Z. and Jordan, I. and Bozdemir, S.E. and Bayhan, G.I. and Beaufils, C. and Bizien, L. and Bisiaux, A. and Lei, W. and Hasan, M. and Chen, J. and Gaughan, C. and Asthana, A. and Libri, V. and Luna, J.M. and Jaffr{\'e}, F. and Hoffmann, H.-H. and Michailidis, E. and Moreews, M. and Seeleuthner, Y. and Bilguvar, K. and Mane, S. and Flores, C. and Zhang, Y. and Arias, A.A. and Bailey, R. and Schl{\"u}ter, A. and Milisavljevic, B. and Bigio, B. and Le Voyer, T. and Materna, M. and Gervais, A. and Moncada-Velez, M. and Pala, F. and Lazarov, T. and Levy, R. and Neehus, A.-L. and Rosain, J. and Peel, J. and Chan, Y.-H. and Morin, M.-P. and Pino-Ramirez, R.M. and Belkaya, S. and Lorenzo, L. and Anton, J. and Delafontaine, S. and Toubiana, J. and Bajolle, F. and Fumad{\'o}, V. and DeDiego, M.L. and Fidouh, N. and Rozenberg, F. and P{\'e}rez-Tur, J. and Chen, S. and Evans, T. and Geissmann, F. and Lebon, P. and Weiss, S.R. and Bonnet, D. and Duval, X. and Pan-Hammarstr{\"o}m, Q. and Planas, A.M. and Meyts, I. and Haerynck, F. and Pujol, A. and Sancho-Shimizu, V. and Dalgard, C.L. and Bustamante, J. and Puel, A. and Boisson-Dupuis, S. and Boisson, B. and Maniatis, T. and Zhang, Q. and Bastard, P. and Notarangelo, L. and B{\'e}ziat, V. and de Diego, R.P. and Rodriguez-Gallego, C. and Su, H.C. and Lifton, R.P. and Jouanguy, E. and Cobat, A. and Alsina, L. and Keles, S. and Haddad, E. and Abel, L. and Belot, A. and Quintana-Murci, L. and Rice, C.M. and Silverman, R.H. and Zhang, S.-Y. and Casanova, J.-L. and Alavoine, L. and Behillil, S. and Burdet, C. and Charpentier, C. and Dechanet, A. and Descamps, D. and Ecobichon, J.-L. and Enouf, V. and Frezouls, W. and Houhou, N. and Kafif, O. and Lehacaut, J. and Letrou, S. and Lina, B. and Lucet, J.-C. and Manchon, P. and Nouroudine, M. and Piquard, V. and Quintin, C. and Thy, M. and Tubiana, S. and van der Werf, S. and Vignali, V. and Visseaux, B. and Yazdanpanah, Y. and Chahine, A. and Waucquier, N. and Migaud, M.-C. and Deplanque, D. and Djossou, F. and Mergeay-Fabre, M. and Lucarelli, A. and Demar, M. and Bruneau, L. and G{\'e}rardin, P. and Maillot, A. and Payet, C. and Laviolle, B. and Laine, F. and Paris, C. and Desille-Dugast, M. and Fouchard, J. and Malvy, D. and Nguyen, D. and Pistone, T. and Perreau, P. and Gissot, V. and Le Goas, C. and Montagne, S. and Richard, L. and Chirouze, C. and Bouiller, K. and Desmarets, M. and Meunier, A. and Lef{\`e}vre, B. and Jeulin, H. and Legrand, K. and Lomazzi, S. and Tardy, B. and Gagneux-Brunon, A. and Bertholon, F. and Botelho-Nevers, E. and Christelle, K. and Nicolas, L. and Roufai, L. and Amat, K. and Couffin-Cadiergues, S. and Esp{\'e}rou, H. and Hendou, S. and Abolhassani, H. and Aguilera-Albesa, S. and Aiuti, A. and Akcan, O.M. and Akcay, N. and Alkan, G. and Alkhater, S.A. and Allende, L.M. and Alper, Y. and Amenzoui, N. and Anderson, M.S. and Arkin, L. and Aubart, M. and Avramenko, I. and Aydemir, ?. and Aydin, Z.G.G. and Aytekin, C. and Aytekin, G. and Aytekin, S.E. and Bando, S.Y. and Beland, K. and Biggs, C.M. and Aburto, A.B. and Blanchard-Rohner, G. and Bl{\'a}zquez-Gamero, D. and Bloomfield, M. and Bogunovic, D. and Bondarenko, A. and Borghesi, A. and Bousfiha, A.A. and Boyarchuk, O. and Brodin, P. and Bryceson, Y. and Bucciol, G. and Calcaterra, V. and Casari, G. and Cavalcanti, A. and Celik, J.B. and Chrousos, G.P. and Colobran, R. and Condino-Neto, A. and Conti, F. and Cooper, M. and Coskuner, T. and Cyrus, C. and D{'}Auria, E. and Drolet, B.A. and Duramaz, B.B. and El Zein, L. and Elnagdy, M.H. and Emiroglu, M. and Erdeniz, E.H. and Fabi, M. and Feldman, H.B. and Fellay, J. and Fencl, F. and Filippatos, F. and Freiss, J. and Fremuth, J. and Gagro, A. and Garcia-Solis, B. and Vergine, G. and Gonz{\'a}lez-Montelongo, R. and Gul, Y. and G{\"u}lhan, B. and Gultekin, S.S.K. and Gut, M. and Halwani, R. and Hammarstr{\"o}m, L. and Hatipo?lu, N. and Heath, J. and Henrickson, S.E. and Hernandez-Brito, E. and Hoffman, I. and Hoste, L. and Hsieh, E. and ?{\~n}igo-Campos, A. and Itan, Y. and Jabandziev, P. and Kandemir, B. and Kanik-Y{\"u}ksek, S. and Kapakli, H. and Karbuz, A. and Kasapcopur, O. and Kechiche, R. and Demirkol, Y.K. and Kilic, O. and Hansen, S.K. and Klocperk, A. and Lau, Y.-L. and Lebl, J. and Lorenzo-Salazar, J.M. and Lucas, C.L. and Maglorius, M. and Marque, L. and Medina, Y.N. and Meli{\'a}n, A.M. and Mentis, A.-F.A. and Pato, M.T. and Michos, A. and Milner, J.D. and Mogensen, T.H. and Mu{\~n}oz-Barrera, A. and Nepesov, S. and Neves, J.F. and Ng, A. and Ng, L.F.P. and Novelli, A. and Novelli, G. and Oz, F.N. and Ocejo-Vi{\~n}als, J.G. and Okada, S. and Orbak, Z. and Kilic, A.O. and Ouair, H. and {\"O}z, ?.K.T. and {\"O}z?elik, T. and {\"O}zkan, E.A. and Parlakay, A.{\"O}. and Pato, C.N. and Paz-Artal, E. and Pelham, S. and Pellier, I. and Philippot, Q. and Planas-Serra, L. and Plassart, S. and Pokorna, P. and Polat, M. and Poli, C. and Prando, C. and Renia, L. and Rivi{\`e}re, J.G. and Rodr{\'i}guez-Palmero, A. and Roussel, L. and Rubio-Rodriguez, L.A. and Salifu, M. and Sasek, L. and Sasia, L. and Scherbina, A. and Schmitt, E. and Sediva, A. and Sevketoglu, E. and Slaba, K. and Slaby, O. and Sobh, A. and Sol{\'e}-Viol{\'a}n, J. and Soler-Palacin, P. and De Somer, L. and S{\"o}zeri, B. and Spaan, A.N. and Stepanovskiy, Y. and Tangye, S.G. and Tanir, G. and Tatsi, E.-B. and Thorball, C.W. and Torun, S.H. and Turvey, S. and Tayoun, A.A. and Ramaswamy, S. and Uddin, M.J. and Uyar, E. and Valencia-Ramos, J. and Van Den Rym, A.M. and Vatansev, H. and de Vera, M.C. and Vermeulen, F. and Vinh, D.C. and Volokha, A. and von Bernuth, H. and Wouters, C. and Yah?i, A. and Yarar, V. and Yesilbas, O. and Yildiz, M. and Zatz, M. and Zawadzki, P. and Zuccotti, G.
DOI: 10.1126/science.abo3627
2023Gestational age at birth and body size from infancy through adolescence: An individual participant data meta-analysis on 253,810 singletons in 16 birth cohort studies
PLoS Medicine
Vinther, J.L. and Cadman, T. and Avraam, D. and Ekstr?m, C.T. and S?rensen, T.I.A. and Elhakeem, A. and Santos, A.C. and de Moira, A.P. and Heude, B. and I{\~n}iguez, C. and Pizzi, C. and Simons, E. and Voerman, E. and Corpeleijn, E. and Zariouh, F. and Santorelli, G. and Inskip, H.M. and Barros, H. and Carson, J. and Harris, J.R. and Nader, J.L. and Ronkainen, J. and Strandberg-Larsen, K. and Santa-Marina, L. and Calas, L. and Cederkvist, L. and Popovic, M. and Charles, M.-A. and Welten, M. and Vrijheid, M. and Azad, M. and Subbarao, P. and Burton, P. and Mandhane, P.J. and Huang, R.-C. and Wilson, R.C. and Haakma, S. and Fern{\'a}ndez-Barr{\'e}s, S. and Turvey, S. and Santos, S. and Tough, S.C. and Sebert, S. and Moraes, T.J. and Salika, T. and Jaddoe, V.W.V. and Lawlor, D.A. and Andersen, A.M.N.
DOI: 10.1371/journal.pmed.1004036
2023Dominant negative variants in IKZF2 cause ICHAD syndrome, a new disorder characterised by immunodysregulation, craniofacial anomalies, hearing impairment, athelia and developmental delay
Journal of Medical Genetics
DOI: 10.1136/jmg-2022-109127
2023Investigating the effect of early life antibiotic use on asthma and allergy risk in over 600 000 Canadian children: A protocol for a retrospective cohort study in British Columbia and Manitoba
BMJ Open
DOI: 10.1136/bmjopen-2022-067271
2023Generation of a human induced pluripotent stem cell line from a patient with hypomyelinating leukodystrophy 22 (HLD22)
Stem Cell Research
DOI: 10.1016/j.scr.2023.103174
2023Delayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease
Nature Communications
DOI: 10.1038/s41467-023-40336-4
2023Cohort profile: investigating SARS-CoV-2 infection and the health and psychosocial impact of the COVID-19 pandemic in the Canadian CHILD Cohort
Epidemiology and Health
DOI: 10.4178/epih.e2023091
2023A germline heterozygous dominant negative IKZF2 variant causing syndromic primary immune regulatory disorder and ICHAD
medRxiv
DOI: 10.1101/2023.09.09.23295301
2023MAGinator enables strain-level quantification of de novo MAGs
bioRxiv
DOI: 10.1101/2023.08.28.555054
2023Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia
Journal of Experimental Medicine
DOI: 10.1084/jem.20220170
2023HostSeq: a Canadian whole genome sequencing and clinical data resource
BMC Genomic Data
DOI: 10.1186/s12863-023-01128-3
2023Homozygous RMRP Promoter Duplications Cause Severely Reduced Transcript Abundance and SCID Associated with Cartilage Hair Hypoplasia
Journal of Clinical Immunology
DOI: 10.1007/s10875-023-01489-5
2023Di-(2-Ethylhexyl) Phthalate (DEHP) in House Dust in Canadian Homes: Behaviors and Associations with Housing Characteristics and Consumer Products
Indoor Air
DOI: 10.1155/2023/4655289
2023Lack of association between HLA and asymptomatic SARS-CoV-2 infection
medRxiv
DOI: 10.1101/2023.12.06.23299623
2023Impact of Cesarean Delivery and Breastfeeding on Secretory Immunoglobulin A in the Infant Gut Is Mediated by Gut Microbiota and Metabolites
Metabolites
Chen, Y.Y. and Tun, H.M. and Field, C.J. and Mandhane, P.J. and Moraes, T.J. and Simons, E. and Turvey, S.E. and Subbarao, P. and Scott, J.A. and Kozyrskyj, A.L.
DOI: 10.3390/metabo13020148
2023Human ASXL1 Deficiency Causes Epigenetic Dysfunction, Combined Immunodeficiency and EBV–Associated Hodgkin Lymphoma
medRxiv
DOI: 10.1101/2023.12.20.23300096
2023Erratum: Gestational age at birth and body size from infancy through adolescence: An individual participant data meta-analysis on 253, 810 singletons in 16 birth cohort studies (PLoS Med (2023) 20:1 (e1004036) DOI: 10.1371/journal.pmed.1004036)
PLoS Medicine
DOI: 10.1371/journal.pmed.1004232
2023Autosomal Recessive Inflammatory Skin Disease Caused by a Novel Biallelic Loss-of-Function Variant in CARD11
Journal of Clinical Immunology
Nguyen, A. and Lu, H.Y. and Bauman, B.M. and Dabbah-Krancher, G. and Zhang, X. and Sukumar, G. and Villar, J. and Bosticardo, M. and Samant, S.A. and Maarup, T.J. and Cheng, J.C. and Kapoor, N. and Cassarino, D.S. and Milner, J.D. and Notarangelo, L.D. and Church, J.A. and Sheikh, J. and Dalgard, C.L. and Turvey, S.E. and Snow, A.L.
DOI: 10.1007/s10875-023-01440-8
2023A second update on mapping the human genetic architecture of COVID-19
Nature
Burt, K. and Spivey, M. and Richards, C. and Tedstone, R. and Carmody, S. and Zhao, X. and Page, V. and Guanco, M.L. and Hoxha, E. and Zorloni, C. and Dean, C. and Jones, E. and Carter, E. and Dunn, J. and Kong, T. and Mahenthran, M. and Marsh, C. and Holland, M. and Keenan, N. and Mahmoud, M. and Lyons, M. and Wassall, H. and Young, M. and Bradley, P. and Burda, D. and Donlon, S. and Harden, L. and Harris, C. and Mayangao, I. and Montaser, R. and Mtuwa, S. and Piercy, C. and Smith, E. and Stone, S. and Verula, J. and Blackman, H. and Marriott, C. and Michalak, N. and Creagh-Brown, B. and Salberg, A. and Boyer, N. and Pristopan, V. and Maynard, V. and Walker, R. and Hormis, A. and Collier, D. and Graham, C. and McCormick, J. and Warrington, J. and Cosgrove, D. and McFarland, D. and Ratcliffe, J. and Charnock, R. and Wynter, I. and Gill, M. and Kirk, J. and Paul, P. and Ratnam, V. and Shelton, S. and Jardine, C. and Hay, A. and Williams, D. and Durga, L. and Hibbert, M. and 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2022Can leaky splicing and evasion of premature termination codon surveillance contribute to the phenotypic variability in Alkuraya-Kucinskas syndrome?
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202216-year trends in asthma hospital admissions in Canada
Annals of Allergy, Asthma and Immunology
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2022Nano-Enabled Reposition of Proton Pump Inhibitors for TLR Inhibition: Toward A New Targeted Nanotherapy for Acute Lung Injury
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2022Human genetic and immunological determinants of critical COVID-19 pneumonia
Nature
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2022A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection
Nature Immunology
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2022Human complete NFAT1 deficiency causes a triad of joint contractures, osteochondromas, and B-cell malignancy
Blood
Sharma, M. and Fu, M.P. and Lu, H.Y. and Sharma, A.A. and Modi, B.P. and Michalski, C. and Lin, S. and Dalmann, J. and Salman, A. and Del Bel, K.L. and Waqas, M. and Terry, J. and Setiadi, A. and Lavoie, P.M. and Wasserman, W.W. and Mwenifumbo, J. and Kobor, M.S. and Lee, A.F. and Kuchenbauer, F. and Lehman, A. and Cheng, S. and Cooper, A. and Patel, M.S. and Turvey, S.E.
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2022From Prescription Drugs to Natural Health Products: Medication Use in Canadian Infants
Children
Bedard, P. and Winsor, G.L. and Garlock, E.S. and Azad, M.B. and Becker, A.B. and Mandhane, P.J. and Moraes, T.J. and Sears, M.R. and Turvey, S.E. and Subbarao, P. and Brinkman, F.S.L. and Kozyrskyj, A.L.
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2022Factors associated with breast-feeding initiation and continuation in Canadian-born and non-Canadian-born women: a multi-centre study
Public Health Nutrition
Chooniedass, R. and Tarrant, M. and Turner, S. and Lok Fan, H.S. and Del Buono, K. and Masina, S. and Becker, A.B. and Mandhane, P. and Turvey, S.E. and Moraes, T. and Sears, M.R. and Subbarao, P. and Azad, M.B.
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2022Assessing secondhand and thirdhand tobacco smoke exposure in Canadian infants using questionnaires, biomarkers, and machine learning
Journal of Exposure Science and Environmental Epidemiology
Parks, J. and McLean, K.E. and McCandless, L. and de Souza, R.J. and Brook, J.R. and Scott, J. and Turvey, S.E. and Mandhane, P.J. and Becker, A.B. and Azad, M.B. and Moraes, T.J. and Lefebvre, D.L. and Sears, M.R. and Subbarao, P. and Takaro, T.K.
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2022Studying severe long COVID to understand post-infectious disorders beyond COVID-19
Nature Medicine
Brodin, P. and Casari, G. and Townsend, L. and O?Farrelly, C. and Tancevski, I. and L{\"o}ffler-Ragg, J. and Mogensen, T.H. and Casanova, J.L. and Abel, L. and Aiuti, A. and Al-Muhsen, S. and Al-Mulla, F. and Anderson, M.S. and Andreakos, E. and Arias, A.A. and Feldman, H.B. and Belot, A. and Biggs, C.M. and Bogunovic, D. and Bolze, A. and Bondarenko, A. and Bousfiha, A.A. and Bryceson, Y. and Bustamante, C.D. and Butte, M.J. and Christodoulou, J. and Condino-Neto, A. and Constantinescu, S.N. and Cooper, M.A. and Dalgard, C.L. and Desai, M. and Drolet, B.A. and Baghdadi, J.E. and Espinosa-Padilla, S. and Fellay, J. and Flores, C. and Franco, J.L. and Froidure, A. and Gregersen, P.K. and Grimbacher, B. and Haerynck, F. and Hagin, D. and Halwani, R. and Hammarstr{\"o}m, L. and Heath, J.R. and Henrickson, S.E. and Hsieh, E.W.Y. and Husebye, E. and Imai, K. and Itan, Y. and Jarvis, E.D. and Karamitros, T. and Kisand, K. and Ku, C.-L. and Lau, Y.-L. and Ling, Y. and Lucas, C.L. and Maniatis, T. and Mansouri, D. and Mar{\'o}di, L. and Meyts, I. and Milner, J.D. and Mironska, K. and Morio, T. and Ng, L.F.P. and Novelli, A. and Novelli, G. and Okada, S. and Okamoto, K. and Ozcelik, T. and Pan-Hammarstr{\"o}m, Q. and Pape, J.W. and de Diego, R.P. and Perlin, D.S. and Pesole, G. and Planas, A.M. and Prando, C. and Pujol, A. and Quintana-Murci, L. and Ramaswamy, S. and Renia, L. and Resnick, I. and Rodr{\'i}guez-Gallego, C. and Sancho-Shimizu, V. and Sediva, A. and Sepp{\"a}nen, M.R.J. and Shahrooei, M. and Shcherbina, A. and Slaby, O. and Snow, A.L. and Soler-Palac{\'i}n, P. and Spaan, A.N. and Tangye, S.G. and Tayoun, A.A. and Turvey, S.E. and Uddin, K.M.F. and Uddin, M.J. and van de Beek, D. and Vinh, D.C. and von Bernuth, H. and Wauters, J. and Zatz, M. and Zawadzki, P. and Casanova, J.-L.
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2022Investigating SARS-CoV-2 infection and the health and psychosocial impact of the COVID-19 pandemic in the Canadian CHILD Cohort: study methodology and cohort profile
medRxiv
Azeez, R. and Lotoski, L. and Dubeau, A. and Rodriguez, N. and Reyna, M.E. and Freitas, T. and Goguen, S. and Medeleanu, M. and Winsor, G.L. and Brinkman, F.S.L. and Cameron, E.E. and Roos, L. and Simons, E. and Moraes, T.J. and Mandhane, P.J. and Turvey, S.E. and Bolotin, S. and Wright, K. and McNeil, D. and Patrick, D.M. and Bullard, J. and Langlois, M.-A. and Arnold, C.R. and Galipeau, Y. and Pelchat, M. and Doucas, N. and Subbarao, P. and Azad, M.B.
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2022Development of a Symptom-Based Tool for Screening of Children at High Risk of Preschool Asthma
JAMA Network Open
Reyna, M.E. and Dai, R. and Tran, M.M. and Breton, V. and Medeleanu, M. and Lou, W.Y.W. and Foong, R.E. and Emmerson, M. and Dharma, C. and Miliku, K. and Lefebvre, D.L. and Simons, E. and Azad, M.B. and Chan-Yeung, M. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Hall, G.L. and Moraes, T.J. and Sears, M.R. and Subbarao, P.
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2022Atopy as Immune Dysregulation: Offender Genes and Targets
Journal of Allergy and Clinical Immunology: In Practice
Vaseghi-Shanjani, M. and Snow, A.L. and Margolis, D.J. and Latrous, M. and Milner, J.D. and Turvey, S.E. and Biggs, C.M.
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2022Sex-specific associations among infant food and atopic sensitizations and infant neurodevelopment
Frontiers in Pediatrics
Rodriguez, N. and Tessier, C.A. and Mandhane, P.J. and Pei, J. and Simons, E. and Moraes, T.J. and Turvey, S.E. and Subbarao, P. and Kozyrskyj, A.L.
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2022Longitudinal body mass index trajectories at preschool age: children with rapid growth have differential composition of the gut microbiota in the first year of life
International Journal of Obesity
Reyna, M.E. and Petersen, C. and Dai, D.L.Y. and Dai, R. and Becker, A.B. and Azad, M.B. and Miliku, K. and Lefebvre, D.L. and Moraes, T.J. and Mandhane, P.J. and Boutin, R.C.T. and Finlay, B.B. and Simons, E. and Kozyrskyj, A.L. and Lou, W. and Turvey, S.E. and Subbarao, P.
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2022Integrating knowledge of protein sequence with protein function for the prediction and validation of new MALT1 substrates
Computational and Structural Biotechnology Journal
Bell, P.A. and Scheuermann, S. and Renner, F. and Pan, C.L. and Lu, H.Y. and Turvey, S.E. and Bornancin, F. and R{\'e}gnier, C.H. and Overall, C.M.
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2022Inborn Errors of Immunity Associated With Type 2 Inflammation in the USIDNET Registry
Frontiers in immunology
Smith, K.L. and Dai, D. and Modi, B.P. and Sara, R. and Garabedian, E. and Marsh, R.A. and Puck, J. and Secord, E. and Sullivan, K.E. and Turvey, S.E. and Biggs, C.M.
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2022Early Life Antimicrobial Exposure: Impact on Clostridioides difficile Colonization in Infants
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Obiakor, C.V. and Parks, J. and Takaro, T.K. and Tun, H.M. and Morales-Lizcano, N. and Azad, M.B. and Mandhane, P.J. and Moraes, T.J. and Simons, E. and Turvey, S.E. and Subbarao, P. and Scott, J.A. and Kozyrskyj, A.L.
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2022The human milk proteome and allergy of mother and child: Exploring associations with protein abundances and protein network connectivity
Frontiers in Immunology
Dekker, P.M. and Azad, M.B. and Boeren, S. and Mandhane, P.J. and Moraes, T.J. and Simons, E. and Subbarao, P. and Turvey, S.E. and Saccenti, E. and Hettinga, K.A.
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2022Prediction of odds for emergency cesarean section: A secondary analysis of the CHILD term birth cohort study
PLoS ONE
Tun, M.H. and Chari, R. and Kaul, P. and Mamede, F.V. and Paulden, M. and Lefebvre, D.L. and Turvey, S.E. and Moraes, T.J. and Sears, M.R. and Subbarao, P. and Mandhane, P.J.
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2022Lung clearance index predicts persistence of preschool wheeze
Pediatric Allergy and Immunology
Safavi, S. and Dai, R. and Breton, V.L. and Emmerson, M.N. and Kowalik, K. and Lu, Z. and Lou, W. and Dubeau, A. and DeLorenzo, S. and Azad, M.B. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Gustafsson, P. and Lefebvre, D.L. and Sears, M.R. and Moraes, T.J. and Subbarao, P.
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2022Decoding the Human Genetic and Immunological Basis of COVID-19 mRNA Vaccine-Induced Myocarditis
Journal of Clinical Immunology
Bolze, A. and Mogensen, T.H. and Zhang, S.-Y. and Abel, L. and Andreakos, E. and Arkin, L.M. and Borghesi, A. and Brodin, P. and Hagin, D. and Novelli, G. and Okada, S. and Peter, J. and Renia, L. and Severe, K. and Tiberghien, P. and Vinh, D.C. and Aiuti, A. and Al-Muhsen, S. and Al-Mulla, F. and Amara, A. and Anderson, M.S. and Arias, A.A. and Feldman, H.B. and Bastard, P. and Belot, A. and Biggs, C.M. and Bogunovic, D. and Bousfiha, A.A. and Butte, M.J. and Christodoulou, J. and Cobat, A. and Colobran, R. and Condino-Neto, A. and Constantinescu, S.N. and Dalgard, C.L. and Duval, X. and Eloy, P. and Espinosa-Padilla, S. and Fellay, J. and Flores, C. and Franco, J.L. and Froidure, A. and Gorochov, G. and Gregersen, P.K. and Haerynck, F. and Halwani, R. and Hammarstr{\"o}m, L. and Itan, Y. and Jouanguy, E. and Karamitros, T. and Lau, Y.-L. and Mansouri, D. and Mentre, F. and Meyts, I. and Mironska, K. and Morio, T. and Ng, L.F.P. and Novelli, A. and O?Farrelly, C. and Okamoto, K. and Ozcelik, T. and Pan-Hammarstr{\"o}m, Q. and de Diego, R.P. and Perez-Tur, J. and Perlin, D.S. and Pesole, G. and Planas, A.M. and Prando, C. and Pujol, A. and Quintana-Murci, L. and Resnick, I. and Rodr{\'i}guez-Gallego, C. and Sancho-Shimizu, V. and Sediva, A. and Sepp{\"a}nen, M.R.J. and Shahrooei, M. and Shcherbina, A. and Slaby, O. and Soler-Palac{\'i}n, P. and Soumelis, V. and Spaan, A.N. and Tancevski, I. and Tangye, S.G. and Tayoun, A.A. and Temel, ?.G. and Thorball, C. and Trouillet-Assant, S. and Turvey, S.E. and Uddin, K.M.F. and van de Beek, D. and von Bernuth, H. and Zhang, Q. and Cirulli, E.T. and Casanova, J.-L. and Hsieh, E.W.Y.
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2022Can tandem alternative splicing and evasion of premature termination codon surveillance contribute to attenuated Peutz–Jeghers syndrome?
American Journal of Medical Genetics, Part A
Gazzaz, N. and Frost, F.G. and Alderman, E. and Richmond, P.A. and Dalmann, J. and Lin, S. and Salman, A. and Del Bel, K.L. and Lehman, A. and Turvey, S.E. and Boerkoel, C.F. and Cherukuri, P.F.
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2022DNA methylation changes in cord blood and the developmental origins of health and disease – a systematic review and replication study
BMC Genomics
Akhabir, L. and Stringer, R. and Desai, D. and Mandhane, P.J. and Azad, M.B. and Moraes, T.J. and Subbarao, P. and Turvey, S.E. and Paré, G. and Anand, S.S. and Anand, S.S. and Atkinson, S.A. and Azad, M.B. and Becker, A.B. and Brook, J. and Denburg, J.A. and de Souza, R.J. and Gupta, M. and Kobor, M. and Lefebvre, D.L. and Lou, W. and Mandhane, P.J. and McDonald, S. and Mente, A. and Meyre, D. and Moraes, T.J. and Morrison, K. and Sears, M.R. and Teo, K.K. and Turvey, S.E. and Wilson, J. and Yusuf, S. and Atkinson, S. and Wahi, G. and Zulyniak, M.A.
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2022Breastfeeding in the First Days of Life Is Associated With Lower Blood Pressure at 3 Years of Age
Journal of the American Heart Association
Kozeta Miliku and Theo J. Moraes and Allan B. Becker and Piushkumar J. Mandhane and Malcolm R. Sears and Stuart E. Turvey and Padmaja Subbarao and Meghan B. Azad
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08/2021World Health Organization growth standards: How do Canadian children measure up?
Paediatrics & Child Health
Celia Rodd and Allison Feely and Allan B Becker and Theo J Moraes and Padmaja Subbarao and Piushkumar J Mandhane and Stuart E Turvey and Diana L Lefebvre and Malcolm R Sears and Meghan B Azad and Atul Sharma
DOI: 10.1093/pch/pxaa053
07/2021Maternal consumption of artificially sweetened beverages during pregnancy is associated with infant gut microbiota and metabolic modifications and increased infant body mass index
Gut Microbes
Isabelle Laforest-Lapointe and Allan B. Becker and Piushkumar J. Mandhane and Stuart E. Turvey and Theo J. Moraes and Malcolm R. Sears and Padmaja Subbarao and Laura K. Sycuro and Meghan B. Azad and Marie-Claire Arrieta
DOI: 10.1080/19490976.2020.1857513
01/2021Bacteroides-dominant gut microbiome of late infancy is associated with enhanced neurodevelopment
Gut Microbes
Sukhpreet K. Tamana and Hein M. Tun and Theodore Konya and Radha S. Chari and Catherine J. Field and David S. Guttman and Allan B. Becker and Theo J. Moraes and Stuart E. Turvey and Padmaja Subbarao and Malcolm R. Sears and Jacqueline Pei and James A. Scott and Piush J. Mandhane and Anita L. Kozyrskyj
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01/2021Newly developed multiple-breath washout reference equations from the CHILD Cohort Study: implications of poorly fitting equations
ERJ Open Research
Zihang Lu and Ruixue Dai and Krzysztof Kowalik and Aimee Dubeau and Diana L. Lefebvre and Susan Balkovec and Allan B. Becker and Piush J. Mandhane and Stuart E. Turvey and Wendy Lou and Felix Ratjen and Theo J. Moraes and Malcolm R. Sears and Per M. Gustafsson and Padmaja Subbarao
DOI: 10.1183/23120541.00301-2020
01/2021Diverse clinical features and diagnostic delay in monogenic inborn errors of immunity: A call for access to genetic testing
Pediatric Allergy and Immunology
Branch, A. and Modi, B. and Bahrani, B. and Hildebrand, K.J. and Cameron, S.B. and Junker, A.K. and Turvey, S.E. and Biggs, C.M.
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2021Mechanistic understanding of the combined immunodeficiency in complete human CARD11 deficiency
Journal of Allergy and Clinical Immunology
Lu, H.Y. and Sharma, M. and Sharma, A.A. and Lacson, A. and Szpurko, A. and Luider, J. and Dharmani-Khan, P. and Shameli, A. and Bell, P.A. and Guilcher, G.M.T. and Lewis, V.A. and Vasquez, M.R. and Desai, S. and McGonigle, L. and Murguia-Favela, L. and Wright, N.A.M. and Sergi, C. and Wine, E. and Overall, C.M. and Suresh, S. and Turvey, S.E.
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2021Harnessing Type I IFN Immunity Against SARS-CoV-2 with Early Administration of IFN-ß
Journal of Clinical Immunology
Vinh, D.C. and Abel, L. and Bastard, P. and Cheng, M.P. and Condino-Neto, A. and Gregersen, P.K. and Haerynck, F. and Cicalese, M.-P. and Hagin, D. and Soler-Palacín, P. and Planas, A.M. and Pujol, A. and Notarangelo, L.D. and Zhang, Q. and Su, H.C. and Casanova, J.-L. and Meyts, I. and Aiuti, A. and Arkin, L.M. and Bolze, A. and Charkravorty, S. and Christodoulou, J. and Colobran, R. and Drolet, B.A. and Fellay, J. and Froidure, P.A. and Pape, J.W. and Halwani, R. and Mogensen, T.H. and Novelli, G. and Resnick, I.B. and Sediva, A. and Tancevski, I. and Turvey, S.
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2021Ethnicity Associations With Food Sensitization Are Mediated by Gut Microbiota Development in the First Year of Life
Gastroenterology
Tun, H.M. and Peng, Y. and Chen, B. and Konya, T.B. and Morales-Lizcano, N.P. and Chari, R. and Field, C.J. and Guttman, D.S. and Becker, A.B. and Mandhane, P.J. and Moraes, T.J. and Sears, M.R. and Turvey, S.E. and Subbarao, P. and Simons, E. and Scott, J.A. and Kozyrskyj, A.L.
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2021X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19
Science Immunology
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mBio
Boutin, R.C.T. and Sbihi, H. and McLaughlin, R.J. and Hahn, A.S. and Konwar, K.M. and Loo, R.S. and Dai, D. and Petersen, C. and Brinkman, F.S.L. and Winsor, G.L. and Sears, M.R. and Moraes, T.J. and Becker, A.B. and Azad, M.B. and Mandhane, P.J. and Subbarao, P. and Turvey, S.E. and Finlay, B.B.
DOI: 10.1128/mBio.03396-20
2021Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths
Science Immunology
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2021A rich meconium metabolome in human infants is associated with early-life gut microbiota composition and reduced allergic sensitization
Cell Reports Medicine
Petersen, C. and Dai, D.L.Y. and Boutin, R.C.T. and Sbihi, H. and Sears, M.R. and Moraes, T.J. and Becker, A.B. and Azad, M.B. and Mandhane, P.J. and Subbarao, P. and Turvey, S.E. and Finlay, B.B.
DOI: 10.1016/j.xcrm.2021.100260
2021Exome sequencing enables diagnosis of X-linked hypohidrotic ectodermal dysplasia in patient with eosinophilic esophagitis and severe atopy
Allergy, Asthma and Clinical Immunology
Modi, B.P. and Del Bel, K.L. and Lin, S. and Sharma, M. and Richmond, P.A. and van Karnebeek, C.D.M. and Chan, E.S. and Avinashi, V. and Rehmus, W.E. and Biggs, C.M. and Wasserman, W.W. and Turvey, S.E.
DOI: 10.1186/s13223-021-00510-z
2021Polygenic risk score for atopic dermatitis in the Canadian population
Journal of Allergy and Clinical Immunology
Simard, M. and Madore, A.-M. and Girard, S. and Waserman, S. and Duan, Q. and Subbarao, P. and Sears, M.R. and Moraes, T.J. and Becker, A.B. and Turvey, S.E. and Mandhane, P.J. and Morin, C. and Bégin, P. and Laprise, C.
DOI: 10.1016/j.jaci.2020.04.057
2021Idiopathic splenomegaly in childhood and the spectrum of RAS-associated lymphoproliferative disease: a case report
BMC Pediatrics
Blanchard-Rohner, G. and Ragotte, R.J. and Junker, A.K. and Sharma, M. and Del Bel, K.L. and Lu, H.Y. and Erdle, S. and Chomyn, A. and Gill, H. and Tucker, L.B. and Schreiber, R.A. and Rozmus, J. and Biggs, C.M. and Hildebrand, K.J. and Wu, J. and Stockler-Ipsiroglu, S. and Turvey, S.E.
DOI: 10.1186/s12887-021-02508-3
2021Establishing a link between antibiotics and asthma in early life
British Columbia Medical Journal
Lishman, H. and Sbihi, H. and Al Mamun, A. and Rasali, D. and Rempel, E. and Smith, N. and Turvey, S. and Patrick, D.M.
2021Development and Validation of SDBeasy Score as a Predictor of Behavioral Outcomes in Childhood
American Journal of Respiratory and Critical Care Medicine
van Eeden, C. and Tamana, S.K. and Narang, I. and Hammam, N. and Chikuma, J. and Lefebvre, D.L. and Azad, M.B. and Moraes, T.J. and Subbarao, P. and Becker, A.B. and Turvey, S.E. and Sears, M.R. and Rasmussen, C. and Pei, J. and Mandhane, P.J.
DOI: 10.1164/rccm.202002-0363OC
2021Clinical and Psychosocial Stress Factors are Associated with Decline in Physical Activity Over Time in Children with Juvenile Idiopathic Arthritis
Research Square
DOI: 10.21203/rs.3.rs-192146/v1
2021Causal pathways to health-related quality of life in children with juvenile idiopathic arthritis: Results from the ReACCh-Out cohort
Rheumatology (United Kingdom)
Oen, K. and Tian, J. and Loughin, T.M. and Shiff, N.J. and Tucker, L.B. and Huber, A.M. and Berard, R.A. and Levy, D.M. and Rumsey, D.G. and Tse, S.M. and Chan, M. and Feldman, B.M. and Duffy, C.M. and Guzman, J. and Bolaria, R. and Cabral, D. and Gross, K. and Houghton, K. and Morishita, K. and Petty, R. and Turvey, S.E. and Ellsworth, J. and Benseler, S. and Johnson, N. and Miettunen, P. and Schmeling, H. and Larche, M. and Cameron, B. and Laxer, R.M. and Spiegel, L. and Schneider, R. and Silverman, E. and Yeung, R.S.M. and Gibbon, M. and Roth, J. and Duffy, K.W. and Chetaille, A.-L. and Dorval, J. and Boire, G. and Bruns, A. and Campillo, S. and Chedeville, G. and LeBlanc, C. and Scuccimarri, R. and Haddad, E. and St. Cyr, C. and Feldman, D. and Lang, B. and Ramsey, S.E. and Stringer, E. and Dancey, P.
DOI: 10.1093/rheumatology/keab079
2021Influence of Neighborhood Characteristics and Weather on Movement Behaviors at Age 3 and 5 Years in a Longitudinal Birth Cohort
Journal of Physical Activity and Health
Ezeugwu, V.E. and Mandhane, P.J. and Hammam, N. and Brook, J.R. and Tamana, S.K. and Hunter, S. and Chikuma, J. and Lefebvre, D.L. and Azad, M.B. and Moraes, T.J. and Subbarao, P. and Becker, A.B. and Turvey, S.E. and Rosu, A. and Sears, M.R. and Carson, V.
DOI: 10.1123/JPAH.2020-0827
2021Human MALT1 deficiency and predisposition to infections
Current Opinion in Immunology
Lu, H.Y. and Turvey, S.E.
DOI: 10.1016/j.coi.2021.02.008
2021Higher concentrations of vitamin D in Canadian children with juvenile idiopathic arthritis compared to healthy controls are associated with more frequent use of vitamin D supplements and season of birth
Nutrition Research
Finch, S.L. and Rosenberg, A.M. and Kusalik, A.J. and Maleki, F. and Rezaei, E. and Baxter-Jones, A. and Benseler, S. and Boire, G. and Cabral, D. and Campillo, S. and Chédeville, G. and Chetaille, A.-L. and Dancey, P. and Duffy, C. and Duffy, K.W. and Guzman, J. and Houghton, K. and Huber, A.M. and Jurencak, R. and Lang, B. and Laxer, R.M. and Morishita, K. and Oen, K.G. and Petty, R.E. and Ramsey, S.E. and Roth, J. and Schneider, R. and Scuccimarri, R. and Stringer, E. and Tse, S.M.L. and Tucker, L.B. and Turvey, S.E. and Szafron, M. and Whiting, S. and Yeung, R.S. and Vatanparast, H.
DOI: 10.1016/j.nutres.2021.05.007
2021Early life exposure to phthalates and the development of childhood asthma among Canadian children
Environmental Research
Navaranjan, G. and Diamond, M.L. and Harris, S.A. and Jantunen, L.M. and Bernstein, S. and Scott, J.A. and Takaro, T.K. and Dai, R. and Lefebvre, D.L. and Azad, M.B. and Becker, A.B. and Mandhane, P.J. and Moraes, T.J. and Simons, E. and Turvey, S.E. and Sears, M.R. and Subbarao, P. and Brook, J.R.
DOI: 10.1016/j.envres.2021.110981
2021Development of a Conceptual Model of Childhood Asthma to Inform Asthma Prevention Policies
Amin Adibi and Stuart E Turvey and Tae Yoon Lee and Malcolm R Sears and Allen B Becker and Piush J Mandhane and Theo J Moraes and Padmaja Subbarao and Mohsen Sadatsafavi
DOI: 10.1101/2020.12.15.20248275
12/2020A Symptom-Based Algorithm for Screening Preschool Children at Risk of Persistent Asthma Symptoms: The CHILD Cohort Study
SSRN
Dai, R. and Reyna, M.E. and Tran, M.M. and Lou, W.Y.W. and Foong, R.E. and Emmerson, M. and Dharma, C. and Lefebvre, D.L. and Simons, E. and Azad, M.B. and Chan-Yeung, M. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Hall, G.L. and Moraes, T.J. and Sears, M.R. and Subbarao, P.
DOI: 10.2139/ssrn.3716875
2020STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells
EMBO Molecular Medicine
Kahlfuss, S. and Kaufmann, U. and Concepcion, A.R. and Noyer, L. and Raphael, D. and Vaeth, M. and Yang, J. and Pancholi, P. and Maus, M. and Muller, J. and Kozhaya, L. and Khodadadi-Jamayran, A. and Sun, Z. and Shaw, P. and Unutmaz, D. and Stathopulos, P.B. and Feist, C. and Cameron, S.B. and Turvey, S.E. and Feske, S.
DOI: 10.15252/emmm.201911592
2020Sex-specific association of human milk hormones and asthma in the CHILD cohort
Pediatric Allergy and Immunology
Chan, D. and Becker, A.B. and Moraes, T.J. and Mandhane, P.J. and Sears, M.R. and Turvey, S.E. and Subbarao, P. and Field, C.J. and Azad, M.B.
DOI: 10.1111/pai.13219
2020Maternal diet and the serum metabolome in pregnancy: Robust dietary biomarkers generalizable to a multiethnic birth cohort
Current Developments in Nutrition
de Souza, R.J. and Shanmuganathan, M. and Lamri, A. and Atkinson, S.A. and Becker, A. and Desai, D. and Gupta, M. and Mandhane, P.J. and Moraes, T.J. and Morrison, K.M. and Subbarao, P. and Teo, K.K. and Turvey, S.E. and Williams, N.C. and Britz-McKibbin, P. and Anand, S.S.
DOI: 10.1093/cdn/nzaa144
2020Consumption of artificially sweetened beverages during pregnancy impacts infant gut microbiota and body mass index
bioRxiv
Laforest-Lapointe, I. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Moraes, T.J. and Sears, M.R. and Subbarao, P. and Sycuro, L.K. and Azad, M.B. and Arrieta, M.-C.
DOI: 10.1101/2020.04.20.050195
2020Real-World Effectiveness of Common Treatment Strategies for Juvenile Idiopathic Arthritis: Results From a Canadian Cohort
Arthritis Care and Research
Chhabra, A. and Oen, K. and Huber, A.M. and Shiff, N.J. and Boire, G. and Benseler, S.M. and Berard, R.A. and Scuccimarri, R. and Feldman, B.M. and Lim, L.S.H. and Barsalou, J. and Bruns, A. and Cabral, D.A. and Chédeville, G. and Ellsworth, J. and Houghton, K. and Lang, B. and Morishita, K. and Rumsey, D.G. and Rosenberg, A.M. and Tse, S.M. and Watanabe Duffy, K. and Duffy, C.M. and Guzman, J. and Bolaria, R. and Gross, K. and Turvey, S.E. and Chan, M. and Tucker, L.B. and Petty, R. and Johnson, N. and Luca, N. and Miettunen, P. and Schmeling, H. and Gerhold, K. and Larché, M. and Levy, D.M. and Laxer, R.M. and Feldman, D. and Spiegel, L. and Schneider, R. and Silverman, E. and Cameron, B. and Yeung, R.S.M. and Roth, J. and Jurencak, R. and Gibbon, M. and Chetaille, A.-L. and Dorval, J. and Campillo, S. and LeBlanc, C. and Chédeville, G. and Haddad, E. and Cyr, C.S. and Ramsey, S.E. and Stringer, E. and Dancey, P.
DOI: 10.1002/acr.23922
2020Mining the infant gut microbiota for therapeutic targets against atopic disease
Allergy: European Journal of Allergy and Clinical Immunology
Boutin, R.C.T. and Sbihi, H. and Dsouza, M. and Malhotra, R. and Petersen, C. and Dai, D. and Sears, M.R. and Moraes, T.J. and Becker, A.B. and Azad, M.B. and Mandhane, P.J. and Subbarao, P. and Finlay, B.B. and Turvey, S.E.
DOI: 10.1111/all.14244
2020Timing of Introduction, Sensitization, and Allergy to Highly Allergenic Foods at Age 3 Years in a General-Population Canadian Cohort
Journal of Allergy and Clinical Immunology: In Practice
Simons, E. and Balshaw, R. and Lefebvre, D.L. and Dai, D. and Turvey, S.E. and Moraes, T.J. and Mandhane, P.J. and Azad, M.B. and Sears, M.R. and Subbarao, P. and Becker, A.B.
DOI: 10.1016/j.jaip.2019.09.039
2020Human milk fungi: environmental determinants and inter-kingdom associations with milk bacteria in the CHILD Cohort Study
BMC Microbiology
Moossavi, S. and Moossavi, S. and Moossavi, S. and Fehr, K. and Derakhshani, H. and Sbihi, H. and Robertson, B. and Bode, L. and Brook, J. and Turvey, S.E. and Moraes, T.J. and Becker, A.B. and Becker, A.B. and Mandhane, P.J. and Sears, M.R. and Khafipour, E. and Khafipour, E. and Subbarao, P. and Subbarao, P. and Azad, M.B. and Azad, M.B.
DOI: 10.1186/s12866-020-01829-0
2020Clinical and associated inflammatory biomarker features predictive of short-term outcomes in non-systemic juvenile idiopathic arthritis
Rheumatology (United Kingdom)
Rezaei, E. and Hogan, D. and Trost, B. and Kusalik, A.J. and Boire, G. and Cabral, D.A. and Campillo, S. and Chédeville, G. and Chetaille, A.-L. and Dancey, P. and Duffy, C. and Watanabe Duffy, K. and Gordon, J. and Guzman, J. and Houghton, K. and Huber, A.M. and Jurencak, R. and Lang, B. and Morishita, K. and Oen, K.G. and Petty, R.E. and Ramsey, S.E. and Scuccimarri, R. and Spiegel, L. and Stringer, E. and Taylor-Gjevre, R.M. and Tse, S.M.L. and Tucker, L.B. and Turvey, S.E. and Tupper, S. and Yeung, R.S.M. and Benseler, S. and Ellsworth, J. and Guillet, C. and Karananayake, C. and Muhajarine, N. and Roth, J. and Schneider, R. and Rosenberg, A.M.
DOI: 10.1093/rheumatology/kez615
2020Cardiorespiratory Monitoring Data during Sleep in Healthy Canadian Infants
Annals of the American Thoracic Society
Zina, K.V. and Mariasine, J. and Young, R. and Reyna, M. and Lu, Z. and Subbarao, P. and Moraes, T.J. and Becker, A.B. and Turvey, S.E. and Sears, M.R. and Lefebvre, D.L. and Azad, M.B. and Rasmussen, C. and Pei, J. and Narang, I. and Mandhane, P.J.
DOI: 10.1513/AnnalsATS.201909-703OC
2020Can we prevent allergic disease? Understanding the links between the early life microbiome and allergic diseases of childhood
Current opinion in pediatrics
Petersen, C. and Turvey, S.E.
DOI: 10.1097/MOP.0000000000000956
2020Associations of clinical and inflammatory biomarker clusters with juvenile idiopathic arthritis categories
Rheumatology (United Kingdom)
Rezaei, E. and Hogan, D. and Trost, B. and Kusalik, A.J. and Boire, G. and Cabral, D.A. and Campillo, S. and Chédeville, G. and Chetaille, A.-L. and Dancey, P. and Duffy, C. and Duffy, K.W. and Eng, S.W.M. and Gordon, J. and Guzman, J. and Houghton, K. and Huber, A.M. and Jurencak, R. and Lang, B. and Laxer, R.M. and Morishita, K. and Oen, K.G. and Petty, R.E. and Ramsey, S.E. and Scherer, S.W. and Scuccimarri, R. and Spiegel, L. and Stringer, E. and Taylor-Gjevre, R.M. and Tse, S.M.L. and Tucker, L.B. and Turvey, S.E. and Tupper, S. and Wintle, R.F. and Yeung, R.S.M. and Rosenberg, A.M.
DOI: 10.1093/rheumatology/kez382
2020Increased Mask Use and Fewer Gatherings Associated with Lower SARS-CoV-2 Seropositivity among Young School-Age Children
SSRN
Manny, E. and Carroll, A. and Charlton, C. and Robinson, J. and Subbarao, P. and Azad, M.B. and Moraes, T.J. and Turvey, S.E. and Chikuma, J. and Lefebvre, D.L. and Bell, R.C. and Letourneau, N. and Mandhane, P.J.
DOI: 10.2139/ssrn.3728570
2020Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Science
Zhang, Q. and Liu, Z. and Moncada-Velez, M. and Chen, J. and Ogishi, M. and Bigio, B. and Yang, R. and Arias, A.A. and Zhou, Q. and Han, J.E. and Ugurbil, A.C. and Zhang, P. and Rapaport, F. and Li, J. and Spaan, A.N. and Boisson, B. and Boisson-Dupuis, S. and Bustamante, J. and Puel, A. and Ciancanelli, M.J. and Zhang, S.-Y. and Béziat, V. and Jouanguy, E. and Abel, L. and Cobat, A. and Casanova, J.-L. and Bastard, P. and Korol, C. and Rosain, J. and Philippot, Q. and Chbihi, M. and Lorenzo, L. and Bizien, L. and Neehus, A.-L. and Kerner, G. and Seeleuthner, Y. and Manry, J. and Le Voyer, T. and Boisson, B. and Boisson-Dupuis, S. and Bustamante, J. and Puel, A. and Zhang, S.-Y. and Béziat, V. and Jouanguy, E. and Abel, L. and Cobat, A. and Bastard, P. and Rosain, J. and Philippot, Q. and Chbihi, M. and Lorenzo, L. and Bizien, L. and Neehus, A.-L. and Kerner, G. and Seeleuthner, Y. and Manry, J. and Le Voyer, T. and Boisson, B. and Boisson-Dupuis, S. and Bustamante, J. and Puel, A. and Zhang, S.-Y. and Béziat, V. and Jouanguy, E. and Abel, L. and Cobat, A. and Le Pen, J. and Schneider, W.M. and Razooky, B.S. and Hoffmann, H.-H. and Michailidis, E. and Rice, C.M. and Sabli, I.K.D. and Hodeib, S. and Sancho-Shimizu, V. and Bilguvar, K. and Ye, J. and Maniatis, T. and Bolze, A. and Arias, A.A. and Arias, A.A. and Zhang, Y. and Notarangelo, L.D. and Su, H.C. and Zhang, Y. and Notarangelo, L.D. and Su, H.C. and Onodi, F. and Korniotis, S. and Karpf, L. and Soumelis, V. and Bonnet-Madin, L. and Amara, A. and Dorgham, K. and Gorochov, G. and Smith, N. and Duffy, D. and Moens, L. and Meyts, I. and Meade, P. and García-Sastre, A. and Krammer, F. and Corneau, A. and Masson, C. and Schmitt, Y. and Schlüter, A. and Pujol, A. and Khan, T. and Marr, N. and Fellay, J. and Fellay, J. and Fellay, J. and Roussel, L. and Vinh, D.C. and Shahrooei, M. and Shahrooei, M. and Alosaimi, M.F. and Alsohime, F. and Hasanato, R. and Mansouri, D. and Mansouri, D. and Mansouri, D. and Al-Saud, H. 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DOI: 10.1126/science.abd4585
2020Association of use of cleaning products with respiratory health in a Canadian birth cohort
CMAJ
Parks, J. and McCandless, L. and Dharma, C. and Brook, J. and Turvey, S.E. and Mandhane, P. and Becker, A.B. and Kozyrskyj, A.L. and Azad, M.B. and Moraes, T.J. and Lefebvre, D.L. and Sears, M.R. and Subbarao, P. and Scott, J. and Takaro, T.K.
DOI: 10.1503/cmaj.190819
2020A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection
Cell
Casanova, J.-L. and Su, H.C. and Abel, L. and Aiuti, A. and Almuhsen, S. and Arias, A.A. and Bastard, P. and Biggs, C. and Bogunovic, D. and Boisson, B. and Boisson-Dupuis, S. and Bolze, A. and Bondarenko, A. and Bousfiha, A. and Brodin, P. and Bustamante, J. and Butte, M. and Casari, G. and Ciancanelli, M. and Cobat, A. and Condino-Neto, A. and Cooper, M. and Dalgard, C. and Espinosa, S. and Feldman, H. and Fellay, J. and Franco, J.L. and Hagin, D. and Itan, Y. and Jouanguy, E. and Lucas, C. and Mansouri, D. and Meyts, I. and Milner, J. and Mogensen, T. and Morio, T. and Ng, L. and Notarangelo, L.D. and Okada, S. and Ozcelik, T. and Palacín, P.S. and Planas, A. and Prando, C. and Puel, A. and Pujol, A. and Redin, C. and Renia, L. and Rodriguez Gallego, J.C. and Quintana-Murci, L. and Sancho-Shimizu, V. and Sankaran, V. and Seppänen, M.R.J. and Shahrooei, M. and Snow, A. and Spaan, A. and Tangye, S. and Tur, J.P. and Turvey, S. and Vinh, D.C. and von Bernuth, H. and Wang, X. and Zawadzki, P. and Zhang, Q. and Zhang, S.
DOI: 10.1016/j.cell.2020.05.016
2020The Canadian Rare Diseases Models and Mechanisms (RDMM) Network: Connecting Understudied Genes to Model Organisms
American Journal of Human Genetics
Boycott, K.M. and Campeau, P.M. and Howley, H.E. and Pavlidis, P. and Rogic, S. and Oriel, C. and Berman, J.N. and Hamilton, R.M. and Hicks, G.G. and Lipshitz, H.D. and Masson, J.-Y. and Shoubridge, E.A. and Junker, A. and Leroux, M.R. and McMaster, C.R. and Michaud, J.L. and Turvey, S.E. and Dyment, D. and Innes, A.M. and van Karnebeek, C.D. and Lehman, A. and Cohn, R.D. and MacDonald, I.M. and Rachubinski, R.A. and Frosk, P. and Vandersteen, A. and Wozniak, R.W. and Pena, I.A. and Wen, X.-Y. and Lacaze-Masmonteil, T. and Rankin, C. and Hieter, P.
DOI: 10.1016/j.ajhg.2020.01.009
2020Nonnutritive sweetener consumption during pregnancy, adiposity, and adipocyte differentiation in offspring: evidence from humans, mice, and cells
International Journal of Obesity
Azad, M.B. and Archibald, A. and Tomczyk, M.M. and Head, A. and Cheung, K.G. and de Souza, R.J. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Moraes, T.J. and Sears, M.R. and Subbarao, P. and Dolinsky, V.W.
DOI: 10.1038/s41366-020-0575-x
2020Natural environments in the urban context and gut microbiota in infants
Environment International
Nielsen, C.C. and Gascon, M. and Osornio-Vargas, A.R. and Shier, C. and Guttman, D.S. and Becker, A.B. and Azad, M.B. and Sears, M.R. and Lefebvre, D.L. and Moraes, T.J. and Turvey, S.E. and Subbarao, P. and Takaro, T.K. and Brook, J.R. and Scott, J.A. and Mandhane, P.J. and Tun, H.M. and Kozyrskyj, A.L.
DOI: 10.1016/j.envint.2020.105881
2020Ethnic differences in maternal diet in pregnancy and infant eczema
PLoS ONE
Zulyniak, M.A. and de Souza, R.J. and Shaikh, M. and Ramasundarahettige, C. and Tam, K. and William, N. and Desai, D. and Lefebvre, D.L. and Gupta, M. and Subbarao, P. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Moraes, T. and Azad, M.B. and Teo, K.K. and Sears, M.R. and Anand, S.S. and Atkinson, S.A. and Azad, M.B. and Becker, A.B. and Brook, J. and Denburg, J. and Desai, D. and de Souza, R.J. and Gupta, M. and Kobor, M. and Lefebvre, D.L. and Lou, W. and Mandhane, P.J. and McDonald, S. and Mente, A. and Meyre, D. and Moraes, T.J. and Morrison, K. and Paré, G. and Sears, M.R. and Subbarao, P. and Teo, K.K. and Turvey, S.E. and Wilson, J. and Yusuf, S. and Atkinson, S. and Wahi, G. and Zulyniak, M.A.
DOI: 10.1371/journal.pone.0232170
2020Decreasing antibiotic use, the gut microbiota, and asthma incidence in children: evidence from population-based and prospective cohort studies
The Lancet Respiratory Medicine
Patrick, D.M. and Sbihi, H. and Dai, D.L.Y. and Al Mamun, A. and Rasali, D. and Rose, C. and Marra, F. and Boutin, R.C.T. and Petersen, C. and Stiemsma, L.T. and Winsor, G.L. and Brinkman, F.S.L. and Kozyrskyj, A.L. and Azad, M.B. and Becker, A.B. and Mandhane, P.J. and Moraes, T.J. and Sears, M.R. and Subbarao, P. and Finlay, B.B. and Turvey, S.E.
DOI: 10.1016/S2213-2600(20)30052-7
2020Breastmilk Feeding Practices Are Associated with the Co-Occurrence of Bacteria in Mothers’ Milk and the Infant Gut: the CHILD Cohort Study
Cell Host and Microbe
Fehr, K. and Moossavi, S. and Sbihi, H. and Boutin, R.C.T. and Bode, L. and Robertson, B. and Yonemitsu, C. and Field, C.J. and Becker, A.B. and Mandhane, P.J. and Sears, M.R. and Khafipour, E. and Moraes, T.J. and Subbarao, P. and Finlay, B.B. and Turvey, S.E. and Azad, M.B.
DOI: 10.1016/j.chom.2020.06.009
2020A Germline Mutation in the C2 Domain of PLC¿2 Associated with Gain-of-Function Expands the Phenotype for PLCG2-Related Diseases
Journal of Clinical Immunology
Novice, T. and Kariminia, A. and Del Bel, K.L. and Lu, H. and Sharma, M. and Lim, C.J. and Read, J. and Lugt, M.V. and Hannibal, M.C. and O?Dwyer, D. and Hosler, M. and Scharnitz, T. and Rizzo, J.M. and Zacur, J. and Priatel, J. and Abdossamadi, S. and Bohm, A. and Junker, A. and Turvey, S.E. and Schultz, K.R. and Rozmus, J.
DOI: 10.1007/s10875-019-00731-3
2020The relationship between machine-learning-derived sleep parameters and behavior problems in 3- And 5-year-old children: Results from the CHILD Cohort study
Sleep
Hammam, N. and Sadeghi, D. and Carson, V. and Tamana, S.K. and Ezeugwu, V.E. and Chikuma, J. and Van Eeden, C. and Brook, J.R. and Lefebvre, D.L. and Moraes, T.J. and Subbarao, P. and Becker, A.B. and Turvey, S.E. and Sears, M.R. and Mandhane, P.J.
DOI: 10.1093/sleep/zsaa117
2020Maternal psychological distress before birth influences gut immunity in mid-infancy
Clinical and Experimental Allergy
Kang, L.J. and Vu, K.N. and Koleva, P.T. and Field, C.J. and Chow, A. and Azad, M.B. and Becker, A.B. and Mandhane, P.J. and Moraes, T.J. and Sears, M.R. and Lefebvre, D.L. and Turvey, S.E. and Subbarao, P. and Lou, W.Y.W. and Scott, J.A. and Kozyrskyj, A.L.
DOI: 10.1111/cea.13551
2020Early life exposure to phthalates in the Canadian Healthy Infant Longitudinal Development (CHILD) study: a multi-city birth cohort
Journal of Exposure Science and Environmental Epidemiology
Navaranjan, G. and Takaro, T.K. and Wheeler, A.J. and Diamond, M.L. and Shu, H. and Azad, M.B. and Becker, A.B. and Dai, R. and Harris, S.A. and Lefebvre, D.L. and Lu, Z. and Mandhane, P.J. and McLean, K. and Moraes, T.J. and Scott, J.A. and Turvey, S.E. and Sears, M.R. and Subbarao, P. and Brook, J.R.
DOI: 10.1038/s41370-019-0182-x
2020Measles Maternal Antibodies With Low Avidity Do Not Interfere With the Establishment of Robust Quantity and Quality Antibody Responses After the Primary Dose of Measles, Mumps, and Rubella Vaccine Administered at 12-Months of Age.
Journal of the Pediatric Infectious Diseases Society
Collins CA and Gelinas L and Yasukawa LL and Audet S and Abu-Raya B and Turvey SE and Beeler JA and Kollmann TR and Gans HA
DOI: 10.1093/jpids/piz074
PubMed: 31644795
10/2019Non-nutritive sweetener consumption during pregnancy affects adiposity in mouse and human offspring
Azad MB and Archibald A and Tomczyk MM and Head A and Cheung KG and de Souza RJ and Becker AB and Mandhane PJ and Turvey SE and Moraes TJ and Sears MR and Subbarao P and Dolinsky VW
DOI: 10.1101/713974
07/2019Human Milk Fatty Acid Composition Is Associated with Dietary, Genetic, Sociodemographic and Environmental Factors in the CHILD Cohort (P08-114-19).
Current Developments in Nutrition
Miliku K and Duan QL and Moraes TJ and Becker AB and Mandhane P and Turvey SE and Lefebvre D and Takaro TK and Sears M and Subbarao P and Field CJ and Azad MB
DOI: 10.1093/cdn/nzz044.P08-114-19
06/2019Silencing cryptic specialized metabolism in Streptomyces by the nucleoid-associated protein Lsr2
Gehrke EJ and Zhang X and Pimentel-Elardo SM and Johnson AR and Rees CA and Jones SE and Hindra and Gehrke SS and Turvey S and Boursalie S and Hill JE and Carlson EE and Nodwell JR and Elliot MA
DOI: 10.1101/614727
04/2019An unusual case of Erysipelothrix rhusiopathiae prosthetic joint infection from the Canadian Arctic: whole genome sequencing unable to identify a zoonotic source.
BMC infectious diseases
Groeschel M and Forde T and Turvey S and Joffe AM and Hui C and Naidu P and Mavrot F and Kutz S and Singh AE
DOI: 10.1186/s12879-019-3913-7
PubMed: 30909869
03/2019Novel Exonic Deletions in TTC7A in a Newborn with Multiple Intestinal Atresia and Combined Immunodeficiency
Journal of Clinical Immunology
Saunders, J.R. and Lehman, A. and Turvey, S.E. and Pan, J. and Rajcan-Separovic, E. and Muise, A.M. and Bush, J.W.
DOI: 10.1007/s10875-019-00669-6
2019Size-dependent anti-inflammatory activity of a peptide-gold nanoparticle hybrid in vitro and in a mouse model of acute lung injury
Acta Biomaterialia
Gao, W. and Wang, Y. and Xiong, Y. and Sun, L. and Wang, L. and Wang, K. and Lu, H.Y. and Bao, A. and Turvey, S.E. and Li, Q. and Yang, H.
DOI: 10.1016/j.actbio.2018.12.046
2019Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors
Cell Host and Microbe
Moossavi, S. and Sepehri, S. and Robertson, B. and Bode, L. and Goruk, S. and Field, C.J. and Lix, L.M. and de Souza, R.J. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Subbarao, P. and Moraes, T.J. and Lefebvre, D.L. and Sears, M.R. and Khafipour, E. and Azad, M.B.
DOI: 10.1016/j.chom.2019.01.011
2019TLR9 limits enteric antimicrobial responses and promotes microbiota-based colonisation resistance during Citrobacter rodentium infection
Cellular Microbiology
Yang, H. and Yu, H.B. and Bhinder, G. and Ryz, N.R. and Lee, J. and Yang, H. and Fotovati, A. and Gibson, D.L. and Turvey, S.E. and Reid, G.S. and Vallance, B.A.
DOI: 10.1111/cmi.13026
2019Clostridioides difficile Colonization Is Differentially Associated With Gut Microbiome Profiles by Infant Feeding Modality at 3–4 Months of Age
Frontiers in Immunology
Drall, K.M. and Tun, H.M. and Morales-Lizcano, N.P. and Konya, T.B. and Guttman, D.S. and Field, C.J. and Mandal, R. and Wishart, D.S. and Becker, A.B. and Azad, M.B. and Lefebvre, D.L. and Mandhane, P.J. and Moraes, T.J. and Sears, M.R. and Turvey, S.E. and Subbarao, P. and Scott, J.A. and Kozyrskyj, A.L.
DOI: 10.3389/fimmu.2019.02866
2019Associations between meeting the Canadian 24-Hour Movement Guidelines for the Early Years and behavioral and emotional problems among 3-year-olds
Journal of Science and Medicine in Sport
Carson, V. and Ezeugwu, V.E. and Tamana, S.K. and Chikuma, J. and Lefebvre, D.L. and Azad, M.B. and Moraes, T.J. and Subbarao, P. and Becker, A.B. and Turvey, S.E. and Sears, M.R. and Mandhane, P.J.
DOI: 10.1016/j.jsams.2019.01.003
2019Patterns of health care use related to respiratory conditions in early life: A birth cohort study with linked administrative data
Pediatric Pulmonology
Chen, W. and Subbarao, P. and McGihon, R.E. and Feldman, L.Y. and Zhu, J. and Lou, W. and Gershon, A.S. and Abdullah, K. and Moraes, T.J. and Dubeau, A. and Sears, M.R. and Lefebvre, D.L. and Turvey, S.E. and Mandhane, P.J. and Azad, M.B. and To, T.
DOI: 10.1002/ppul.24381
2019Human milk fatty acid composition is associated with dietary, genetic, sociodemographic, and environmental factors in the CHILD Cohort Study
American Journal of Clinical Nutrition
Miliku, K. and Duan, Q.L. and Moraes, T.J. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Lefebvre, D.L. and Sears, M.R. and Subbarao, P. and Field, C.J. and Azad, M.B.
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2019Germline CBM-opathies: From immunodeficiency to atopy
Journal of Allergy and Clinical Immunology
Lu, H.Y. and Biggs, C.M. and Blanchard-Rohner, G. and Fung, S.-Y. and Sharma, M. and Turvey, S.E.
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2019Risk for Maternal Depressive Symptoms and Perceived Stress by Ethnicities in Canada: From Pregnancy Through the Preschool Years,Risque de symptômes dépressifs maternels et stress perçu par les ethnies au Canada : de la grossesse aux années préscolaires
Canadian Journal of Psychiatry
Dharma, C. and Lefebvre, D.L. and Lu, Z. and Lou, W.Y.W. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Moraes, T.J. and Azad, M.B. and Chen, E. and Elliott, S.J. and Kozyrskyj, A.L. and Sears, M.R. and Subbarao, P.
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2019Complexity in unclassified auto-inflammatory disease: A case report illustrating the potential for disease arising from the allelic burden of multiple variants
Pediatric Rheumatology
Tucker, L.B. and Lamot, L. and Niemietz, I. and Chung, B.K. and Cabral, D.A. and Houghton, K. and Petty, R.E. and Morishita, K.A. and Rice, G.I. and Turvey, S.E. and Gibson, W.T. and Brown, K.L.
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2019Prenatal exposure to traffic-related air pollution, the gestational epigenetic clock, and risk of early-life allergic sensitization
Journal of Allergy and Clinical Immunology
Sbihi, H. and Jones, M.J. and MacIsaac, J.L. and Brauer, M. and Allen, R.W. and Sears, M.R. and Subbarao, P. and Mandhane, P.J. and Moraes, T.J. and Azad, M.B. and Becker, A.B. and Brook, J.R. and Kobor, M.S. and Turvey, S.E.
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2019Maternal Metabolic Complications in Pregnancy and Offspring Behavior Problems at 2 Years of Age
Maternal and Child Health Journal
Krzeczkowski, J.E. and Lau, A. and Fitzpatrick, J. and Tamana, S. and Smithson, L. and de Souza, R. and Kozyrskyj, A.L. and Lefebvre, D. and Becker, A.B. and Subbarao, P. and Turvey, S.E. and Pei, J. and Schmidt, L.A. and Sears, M.R. and Van Lieshout, R.J. and Mandhane, P.J. and Anand, S.S. and Azad, M. and Befus, A.D. and Brauer, M. and Brook, J.R. and Chen, E. and Cyr, M. and Daley, D. and Dell, S. and Denburg, J.A. and Duan, Q. and Eiwegger, T. and Grasemann, H. and HayGlass, K. and Hegele, R. and Holness, D.L. and Hystad, P. and Kobor, M.S. and Kollman, T.R. and Laprise, C. and Lou, W.Y.W. and Macri, J. and Miller, G. and Moraes, T. and Paré, P.D. and Mandhane, P.M. and Ratjen, F. and Sandford, A. and Scott, J.A. and Silverman, F. and Simons, E. and Takaro, T. and Tebbutt, S. and To, T.
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2019Integrated analysis of human milk microbiota with oligosaccharides and fatty acids in the child cohort
Frontiers in Nutrition
Moossavi, S. and Atakora, F. and Miliku, K. and Sepehri, S. and Robertson, B. and Duan, Q.L. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Moraes, T.J. and Lefebvre, D.L. and Sears, M.R. and Subbarao, P. and Field, C.J. and Bode, L. and Khafipour, E. and Azad, M.B.
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2019Associations between concentrations of perfluoroalkyl substances in human plasma and maternal, infant, and home characteristics in Winnipeg, Canada
Environmental Pollution
Workman, C.E. and Becker, A.B. and Azad, M.B. and Moraes, T.J. and Mandhane, P.J. and Turvey, S.E. and Subbarao, P. and Brook, J.R. and Sears, M.R. and Wong, C.S.
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2019An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient
Nature Chemical Biology
Quancard, J. and Klein, T. and Fung, S.-Y. and Renatus, M. and Hughes, N. and Israël, L. and Priatel, J.J. and Kang, S. and Blank, M.A. and Viner, R.I. and Blank, J. and Schlapbach, A. and Erbel, P. and Kizhakkedathu, J. and Villard, F. and Hersperger, R. and Turvey, S.E. and Eder, J. and Bornancin, F. and Overall, C.M.
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2019Thinking bigger: How early-life environmental exposures shape the gut microbiome and influence the development of asthma and allergic disease
Allergy: European Journal of Allergy and Clinical Immunology
Sbihi, H. and Boutin, R.C.T. and Cutler, C. and Suen, M. and Finlay, B.B. and Turvey, S.E.
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2019Screen-time is associated with inattention problems in preschoolers: Results from the CHILD birth cohort study
PLoS ONE
Tamana, S.K. and Ezeugwu, V. and Chikuma, J. and Lefebvre, D.L. and Azad, M.B. and Moraes, T.J. and Subbarao, P. and Becker, A.B. and Turvey, S.E. and Sears, M.R. and Dick, B.D. and Carson, V. and Rasmussen, C. and Pei, J. and Mandhane, P.J.
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2019Prenatal depression and birth mode sequentially mediate maternal education's influence on infant sleep duration
Sleep Medicine
Matenchuk, B.A. and Tamana, S.K. and Lou, W.Y.W. and Lefebvre, D.L. and Sears, M.R. and Becker, A.B. and Azad, M.B. and Moraes, T.J. and Turvey, S.E. and Subbarao, P. and Kozyrskyj, A.L. and Mandhane, P.J. and Anand, S.S. and Befus, A.D. and Brauer, M. and Brook, J.R. and Chen, E. and Cyr, M.M. and Daley, D. and Dell, S.D. and Denburg, J.A. and Duan, Q.L. and Eiwegger, T. and Grasemann, H. and Hegele, R.G. and Holness, D.L. and Hystad, P. and Kobor, M. and Kollmann, T.R. and Laprise, C. and Macri, J. and Miller, G. and Paré, P. and Ramsey, C. and Ratjen, F. and Sandford, A. and Scott, J.A. and Silverman, F. and Simons, E. and Takaro, T. and Tebbutt, S.J. and To, T.
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2019Predicting which children with juvenile idiopathic arthritis will not attain early remission with conventional treatment: Results from the Reacch-out cohort
Journal of Rheumatology
Guzman, J. and Henrey, A. and Loughin, T. and Berard, R.A. and Shiff, N.J. and Jurencak, R. and Huber, A.M. and Oen, K. and Gerhold, K. and Feldman, B.M. and Scuccimarri, R. and Houghton, K. and Chédeville, G. and Morishita, K. and Lang, B. and Dancey, P. and Rosenberg, A.M. and Barsalou, J. and Bruns, A. and Duffy, K.W. and Benseler, S. and Duffy, C.M. and Tucker, L.B. and Bolaria, R. and Gross, K. and Turvey, S.E. and Cabral, D. and Petty, R. and Ellsworth, J. and Johnson, N. and Miettunen, P. and Schmeling, H. and Larché, M. and Levy, D.M. and Laxer, R.M. and Feldman, D. and Spiegel, L. and Schneider, R. and Tse, S.M.L. and Silverman, E. and Cameron, B. and Yeung, R.S.M. and Roth, J. and Gibbon, M. and Chetaille, A.-L. and Dorval, J. and Boire, G. and Campillo, S. and LeBlanc, C. and Haddad, E. and Cyr, C.St. and Ramsey, S.E. and Stringer, E.
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2019Reduced genetic potential for butyrate fermentation in the gut microbiome of infants who develop allergic sensitization
Journal of Allergy and Clinical Immunology
Cait, A. and Cardenas, E. and Dimitriu, P.A. and Amenyogbe, N. and Dai, D. and Cait, J. and Sbihi, H. and Stiemsma, L. and Subbarao, P. and Mandhane, P.J. and Becker, A.B. and Moraes, T.J. and Sears, M.R. and Lefebvre, D.L. and Azad, M.B. and Kollmann, T. and Turvey, S.E. and Mohn, W.W.
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2019Trajectories of depressive symptoms and perceived stress from pregnancy to the postnatal period among Canadian women: Impact of employment and immigration
American Journal of Public Health
Chow, A. and Dharma, C. and Chen, E. and Mandhane, P.J. and Turvey, S.E. and Elliott, S.J. and Becker, A.B. and Subbarao, P. and Sears, M.R. and Kozyrskyj, A.L.
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2019IL1RN Variation Influences Both Disease Susceptibility and Response to Recombinant Human Interleukin-1 Receptor Antagonist Therapy in Systemic Juvenile Idiopathic Arthritis.
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Journal of the Canadian Association of Gastroenterology
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02/2018Association of exposure to formula in the hospital and subsequent infant feeding practices with gut microbiota and risk of overweight in the first year of life
JAMA Pediatrics
Forbes, J.D. and Azad, M.B. and Vehling, L. and Tun, H.M. and Konya, T.B. and Guttman, D.S. and Field, C.J. and Lefebvre, D. and Sears, M.R. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Moraes, T.J. and Subbarao, P. and Scott, J.A. and Kozyrskyj, A.L. and Anand, S.S. and Befus, A.D. and Brauer, M. and Brook, J.R. and Chen, E. and Cyr, M.M. and Daley, D. and Dell, S.D. and Denburg, J.A. and Duan, Q.L. and Eiwegger, T. and Grasemann, H. and HayGlass, K. and Hegele, R.G. and Holness, D.L. and Hystad, P. and Kobor, M. and Kollmann, T.R. and Laprise, C. and Lou, W.Y.W. and Macri, J. and Miller, G. and Pare, P. and Ramsey, C. and Ratjen, F. and Sandford, A. and Scott, J. and Silverman, F. and Simons, E. and Takaro, T. and Tebbutt, S.J. and To, T.
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2018IVIg and LPS co-stimulation induces IL-10 production by human monocytes, which is compromised by an Fc¿RIIA disease-associated gene variant
Frontiers in Immunology
Kozicky, L.K. and Menzies, S.C. and Zhao, Z.Y. and Vira, T. and Harnden, K. and Safari, K. and Del Bel, K.L. and Turvey, S.E. and Sly, L.M.
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2018Shorter sleep duration is associated with reduced cognitive development at two years of age
Sleep Medicine
Smithson, L. and Baird, T. and Tamana, S.K. and Lau, A. and Mariasine, J. and Chikuma, J. and Lefebvre, D.L. and Subbarao, P. and Becker, A.B. and Turvey, S.E. and Sears, M.R. and Beal, D.S. and Pei, J. and Mandhane, P.J.
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2018Phenotypes of sleep-disordered breathing symptoms to two years of age based on age of onset and duration of symptoms
Sleep Medicine
Kamal, M. and Tamana, S.K. and Smithson, L. and Ding, L. and Lau, A. and Chikuma, J. and Mariasine, J. and Lefebvre, D.L. and Subbarao, P. and Becker, A.B. and Turvey, S.E. and Sears, M.R. and Pei, J. and Mandhane, P.J.
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2018Peptide–Gold Nanoparticle Hybrids as Promising Anti-Inflammatory Nanotherapeutics for Acute Lung Injury: In Vivo Efficacy, Biodistribution, and Clearance
Advanced Healthcare Materials
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2018Maternal depressive symptoms linked to reduced fecal Immunoglobulin A concentrations in infants
Brain, Behavior, and Immunity
Kang, L.J. and Koleva, P.T. and Field, C.J. and Giesbrecht, G.F. and Wine, E. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Subbarao, P. and Sears, M.R. and Scott, J.A. and Kozyrskyj, A.L.
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2018Human Milk Oligosaccharide Concentrations Are Associated with Multiple Fixed and Modifiable Maternal Characteristics, Environmental Factors, and Feeding Practices
Journal of Nutrition
Azad, M.B. and Robertson, B. and Atakora, F. and Becker, A.B. and Subbarao, P. and Moraes, T.J. and Mandhane, P.J. and Turvey, S.E. and Lefebvre, D.L. and Sears, M.R. and Bode, L.
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2018What do participants in a birth cohort study know about their homes?
15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018
Lepine, C. and Brook, J. and Takaro, T. and Subbarao, P. and Turvey, S. and Mandhane, P. and Becker, A. and Lefebvre, D. and Sears, M. and Scott, J. and Siegel, J.A.
2018Predicting the atopic march: Results from the Canadian Healthy Infant Longitudinal Development Study
Journal of Allergy and Clinical Immunology
Tran, M.M. and Lefebvre, D.L. and Dharma, C. and Dai, D. and Lou, W.Y.W. and Subbarao, P. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Sears, M.R. and Anand, S.S. and Azad, M. and Befus, A.D. and Brauer, M. and Brook, J.R. and Chen, E. and Cyr, M. and Daley, D. and Dell, S.D. and Denburg, J.A. and Duan, Q. and Eiwegger, T. and Grasemann, H. and HayGlass, K. and Hegele, R.G. and Holness, D.L. and Hystad, P. and Kobor, M. and Kollmann, T.R. and Kozyrskyj, A.L. and Laprise, C. and Macri, J. and Miller, G. and Moraes, T.J. and Paré, P. and Ramsey, C. and Ratjen, F. and Sandford, A. and Scott, J.A. and Scott, J. and Silverman, F. and Simons, E. and Takaro, T. and Tebbutt, S. and To, T.
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2018Postnatal exposure to household disinfectants, infant gut microbiota and subsequent risk of overweight in children
CMAJ
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2018Combination therapy with proteasome inhibitors and TLR agonists enhances tumour cell death and IL-1ß production article/96/21
Cell Death and Disease
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2018Adiponectin, leptin and insulin in breast milk: Associations with maternal characteristics and infant body composition in the first year of life
International Journal of Obesity
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2018The importance of functional validation after next-generation sequencing: evaluation of a novel CARD11 variant
Pediatric Allergy and Immunology
Lu, H.Y. and Sharma, M. and Biggs, C.M. and Huang, Y.-H. and Shopsowitz, K.E. and Frosk, P. and Priatel, J.J. and Rubin, T.S. and Turvey, S.E.
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2018The CBM-opathies—a rapidly expanding spectrum of human inborn errors of immunity caused by mutations in the CARD11-BCL10-MALT1 complex
Frontiers in Immunology
Lu, H.Y. and Bauman, B.M. and Arjunaraja, S. and Dorjbal, B. and Milner, J.D. and Snow, A.L. and Turvey, S.E.
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2018Reference equations for the interpretation of forced expiratory and plethysmographic measurements in infants
Pediatric Pulmonology
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2018Associations between infant fungal and bacterial dysbiosis and childhood atopic wheeze in a nonindustrialized setting
Journal of Allergy and Clinical Immunology
Arrieta, M.-C. and Arévalo, A. and Stiemsma, L. and Dimitriu, P. and Chico, M.E. and Loor, S. and Vaca, M. and Boutin, R.C.T. and Morien, E. and Jin, M. and Turvey, S.E. and Walter, J. and Parfrey, L.W. and Cooper, P.J. and Finlay, B.
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2018Ventilation inhomogeneity in infants with recurrent wheezing
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2018Trajectories of pain severity in juvenile idiopathic arthritis: Results from the Research in Arthritis in Canadian Children Emphasizing Outcomes cohort
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2018Impact of maternal pre-pregnancy overweight on infant overweight at 1 year of age: associations and sex-specific differences
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2018Human milk oligosaccharide profiles and food sensitization among infants in the CHILD Study
Allergy: European Journal of Allergy and Clinical Immunology
Miliku, K. and Robertson, B. and Sharma, A.K. and Subbarao, P. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Lefebvre, D.L. and Sears, M.R. and Bode, L. and Azad, M.B.
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2018Diagnosing atopic dermatitis in infancy: Questionnaire reports vs criteria-based assessment
Paediatric and Perinatal Epidemiology
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2018Patterns of allergic sensitization and atopic dermatitis from 1 to 3 years: Effects on allergic diseases
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2018Parent-reported symptoms of sleep-disordered breathing are associated with increased behavioral problems at 2 years of age: The Canadian healthy infant longitudinal development birth cohort study
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2018Roles of birth mode and infant gut microbiota in intergenerational transmission of overweight and obesity from mother to offspring
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2018Residential green space and pathways to term birth weight in the Canadian Healthy Infant Longitudinal Development (CHILD) Study
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2018Infant feeding and weight gain: Separating breast milk from breastfeeding and formula from food
Pediatrics
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2018Exclusive breastfeeding in hospital predicts longer breastfeeding duration in Canada: Implications for health equity
Birth
Vehling, L. and Chan, D. and McGavock, J. and Becker, A.B. and Subbarao, P. and Moraes, T.J. and Mandhane, P.J. and Turvey, S.E. and Lefebvre, D.L. and Sears, M.R. and Azad, M.B.
DOI: 10.1111/birt.12345
2018Mycobacterium branderi infection: Case report and literature review of an unusual and difficult-to-treat non-tuberculous mycobacterium.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Turvey SL and Tyrrell GJ and Hernandez C and Kabbani D and Doucette K and Cervera C
DOI: 10.1016/j.ijid.2017.03.002
PubMed: 28268125
03/2017Epidemiology and Outcomes in Critically Ill Patients with Human Immunodeficiency Virus Infection in the Era of Combination Antiretroviral Therapy.
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
Turvey SL and Bagshaw SM and Eurich DT and Sligl WI
DOI: 10.1155/2017/7868954
PubMed: 28348607
02/2017Breastfeeding, maternal asthma and wheezing in the first year of life: A longitudinal birth cohort study
European Respiratory Journal
Azad, M.B. and Vehling, L. and Lu, Z. and Dai, D. and Subbarao, P. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Lefebvre, D.L. and Sears, M.R. and Anand, S.S. and Befus, A.D. and Brauer, M. and Brook, J.R. and Chen, E. and Cyr, M. and Daley, D. and Dell, S. and Denburg, J.A. and Duan, Q. and Eiwegger, T. and Grasemann, H. and HayGlass, K. and Hegele, R. and Holness, D.L. and Hystad, P. and Lou, W.Y.W. and Kobor, M.S. and Kollman, T.R. and Kozyrskyj, A.L. and Laprise, C. and Macri, J. and Mandhane, P.M. and Miller, G. and Moraes, T. and Paré, P.D. and Ramsey, C. and Ratjen, F. and Sandford, A. and Scott, J.A. and Scott, J. and Silverman, F. and Simons, E. and Takaro, T. and Tebbutt, S. and To, T.
DOI: 10.1183/13993003.02019-2016
2017JAK1 gain-of-function causes an autosomal dominant immune dysregulatory and hypereosinophilic syndrome
Journal of Allergy and Clinical Immunology
Del Bel, K.L. and Ragotte, R.J. and Saferali, A. and Lee, S. and Vercauteren, S.M. and Mostafavi, S.A. and Schreiber, R.A. and Prendiville, J.S. and Phang, M.S. and Halparin, J. and Au, N. and Dean, J.M. and Priatel, J.J. and Jewels, E. and Junker, A.K. and Rogers, P.C. and Seear, M. and McKinnon, M.L. and Turvey, S.E.
DOI: 10.1016/j.jaci.2016.12.957
2017Pre-diagnostic genotyping identifies T1D subjects with impaired Treg IL-2 signaling and an elevated proportion of FOXP3+ IL-17+ cells
Genes and Immunity
Marwaha, A.K. and Panagiotopoulos, C. and Biggs, C.M. and Staiger, S. and Del Bel, K.L. and Hirschfeld, A.F. and Priatel, J.J. and Turvey, S.E. and Tan, R.
DOI: 10.1038/gene.2016.44
2017In vivo immune signatures of healthy human pregnancy: Inherently inflammatory or anti-inflammatory?
PLoS ONE
Graham, C. and Chooniedass, R. and Stefura, W.P. and Becker, A.B. and Sears, M.R. and Turvey, S.E. and Mandhane, P.J. and Subbarao, P. and HayGlass, K.T. and Sears, M.R. and Subbarao, P. and Allen, R. and Anand, S.S. and Becker, A.B. and Befus, A.D. and Brauer, M. and Brook, J.R. and Chen, E. and Cyr, M. and Daley, D. and Dell, S. and Denburg, J.A. and Elliott, S. and Grasemann, H. and Hay-Glass, K. and Hegele, R. and Holness, D.L. and Lou, W.Y.W. and Kobor, M.S. and Kollman, T.R. and Kozyrskyj, A.A. and Laprise, C. and Larche, M. and Macri, J. and Mandhane, P.M. and Miller, G. and Moqbel, R. and Moraes, T. and Pare, P.D. and Ramsey, C. and Ratjen, F. and Sandford, A. and Scott, J.A. and Scott, J. and Silverman, F. and Takaro, T. and Tang, P. and Tebbutt, S. and To, T.
DOI: 10.1371/journal.pone.0177813
2017Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
Journal of visualized experiments : JoVE
Yang, H. and Fung, S.Y. and Bao, A. and Li, Q. and Turvey, S.E.
DOI: 10.3791/56075
2017Timing of food introduction and development of food sensitization in a prospective birth cohort
Pediatric Allergy and Immunology
Tran, M.M. and Lefebvre, D.L. and Dai, D. and Dharma, C. and Subbarao, P. and Lou, W. and Azad, M.B. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Sears, M.R. and Anand, S.S. and Befus, A.D. and Brauer, M. and Brook, J.R. and Chen, E. and Cyr, M.M. and Daley, D. and Dell, S.D. and Denburg, J.A. and Duan, Q.L. and Eiwegger, T. and Grasemann, H. and HayGlass, K. and Hegele, R.G. and Holness, D.L. and Hystad, P. and Kobor, M. and Kollmann, T.R. and Kozyrskyj, A.L. and Laprise, C. and Miller, G. and Moraes, T.J. and Paré, P. and Ramsey, C. and Ratjen, F. and andford, A. and Scott, J.A. and Scott, J. and Silverman, F. and Simons, E. and Takaro, T. and Tebbutt, S.J. and To, T.
DOI: 10.1111/pai.12739
2017Canadian Society of Allergy and Clinical Immunology annual scientific meeting 2016.
Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
2017Asthma and the microbiome: Defining the critical window in early life
Allergy, Asthma and Clinical Immunology
Stiemsma, L.T. and Turvey, S.E.
DOI: 10.1186/s13223-016-0173-6
2017Modes of Infant Feeding and the Risk of Childhood Asthma: A Prospective Birth Cohort Study
Journal of Pediatrics
Klopp, A. and Vehling, L. and Becker, A.B. and Subbarao, P. and Mandhane, P.J. and Turvey, S. and Lefebvre, D.L. and Sears, M.R. and Daley, D. and Silverman, F. and Hayglass, K. and Kobor, M. and Kollmann, T. and Brook, J. and Ramsey, C. and Macri, J. and Sandford, A. and Pare, P. and Tebbutt, S. and Brauer, M. and Denburg, J. and Cyr, M. and Kozyrskyj, A. and Becker, A. and Takaro, T. and Ratjen, F. and Grasemann, H. and Dell, S. and To, T. and Moraes, T. and Holness, L. and Befus, A.D. and Scott, J. and Hegele, R. and Lou, W. and Anand, S. and Sears, M. and Simons, E. and Azad, M. and Eiwegger, T. and Duan, Q. and Hystad, P. and Scott, J. and Azad, M.B.
DOI: 10.1016/j.jpeds.2017.07.012
2017Growth and weight gain in children with juvenile idiopathic arthritis: Results from the ReACCh-Out cohort
Pediatric Rheumatology
Guzman, J. and Kerr, T. and Ward, L.M. and Ma, J. and Oen, K. and Rosenberg, A.M. and Feldman, B.M. and Boire, G. and Houghton, K. and Dancey, P. and Scuccimarri, R. and Bruns, A. and Huber, A.M. and Watanabe Duffy, K. and Shiff, N.J. and Berard, R.A. and Levy, D.M. and Stringer, E. and Morishita, K. and Johnson, N. and Cabral, D.A. and Larché, M. and Petty, R.E. and Laxer, R.M. and Silverman, E. and Miettunen, P. and Chetaille, A.-L. and Haddad, E. and Spiegel, L. and Turvey, S.E. and Schmeling, H. and Lang, B. and Ellsworth, J. and Ramsey, S.E. and Roth, J. and Campillo, S. and Benseler, S. and Chédeville, G. and Schneider, R. and Tse, S.M.L. and Bolaria, R. and Gross, K. and Feldman, D. and Cameron, B. and Jurencak, R. and Dorval, J. and LeBlanc, C. and St. Cyr, C. and Gibbon, M. and Yeung, R.S.M. and Duffy, C.M. and Tucker, L.B.
DOI: 10.1186/s12969-017-0196-7
2017Fecal Short-Chain Fatty Acid Variations by Breastfeeding Status in Infants at 4 Months: Differences in Relative versus Absolute Concentrations
Frontiers in Nutrition
Bridgman, S.L. and Azad, M.B. and Field, C.J. and Haqq, A.M. and Becker, A.B. and Mandhane, P.J. and Subbarao, P. and Turvey, S.E. and Sears, M.R. and Scott, J.A. and Wishart, D.S. and Kozyrskyj, A.L.
DOI: 10.3389/fnut.2017.00011
2017Exposure to household furry pets influences the gut microbiota of infants at 3-4 months following various birth scenarios
Microbiome
Tun, H.M. and Konya, T. and Takaro, T.K. and Brook, J.R. and Chari, R. and Field, C.J. and Guttman, D.S. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Subbarao, P. and Sears, M.R. and Scott, J.A. and Kozyrskyj, A.L. and Anand, S.S. and Cyr, M. and Denburg, J.A. and Macri, J. and Eiwegger, T. and Azad, M. and HayGlass, K. and Ramsey, C. and Simons, E. and Befus, A.D. and Brauer, M. and Daley, D. and Kobor, M.S. and Kollmann, T.R. and Paré, P.D. and Sandford, A. and Tebbutt, S. and Holness, D.L. and Lou, W.Y.W. and Scott, J. and Silverman, F. and Chen, E. and Miller, G. and Dell, S. and Grasemann, H. and Hegele, R. and Moraes, T. and Ratjen, F. and To, T. and Duan, Q. and Hystad, P. and Laprise, C. and Takaro, T.
DOI: 10.1186/s40168-017-0254-x
2017Endoplasmic reticulum stress and chemokine production in cystic fibrosis airway cells: Regulation by STAT3 modulation
Journal of Infectious Diseases
Tang, A.C. and Saferali, A. and He, G. and Sandford, A.J. and Strug, L. and Turvey, S.E.
DOI: 10.1093/infdis/jiw516
2017Does the impact of a plant-based diet during pregnancy on birth weight differ by ethnicity? A dietary pattern analysis from a prospective Canadian birth cohort alliance
BMJ Open
Zulyniak, M.A. and De Souza, R.J. and Shaikh, M. and Desai, D. and Lefebvre, D.L. and Gupta, M. and Wilson, J. and Wahi, G. and Subbarao, P. and Becker, A.B. and Mandhane, P. and Turvey, S.E. and Beyene, J. and Atkinson, S. and Morrison, K.M. and McDonald, S. and Teo, K.K. and Sears, M.R. and Anand, S.S.
DOI: 10.1136/bmjopen-2017-017753
2017Sex-specific impact of asthma during pregnancy on infant gut microbiota
The European respiratory journal
Koleva, P.T. and Tun, H.M. and Konya, T. and Guttman, D.S. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Subbarao, P. and Sears, M.R. and Scott, J.A. and Kozyrskyj, A.L.
DOI: 10.1183/13993003.00280-2017
2017Respiratory syncytial virus-neutralizing serum antibody titers in infants following palivizumab prophylaxis with an abbreviated dosing regimen
PLoS ONE
Claydon, J. and Sur, A. and Callejas, A. and Ladd, M. and Kwan, E. and Taylor, R. and Turvey, S.E. and Solimano, A. and Lavoie, P.M. and Marr, N.
DOI: 10.1371/journal.pone.0176152
2017Newborn screening for severe combined immunodeficiency: A primer for clinicians
CMAJ
Biggs, C.M. and Haddad, E. and Issekutz, T.B. and Roifman, C.M. and Turvey, S.E.
DOI: 10.1503/cmaj.170561
2017EVER1 and EVER2 Mutations in Epidermodysplasia Verruciformis
Encyclopedia of Medical Immunology
Robert J Ragotte and Stuart E Turvey
DOI: 10.1007/978-1-4614-9209-2_50-1
2017Ethnic and diet-related differences in the healthy infant microbiome
Genome Medicine
Stearns, J.C. and Zulyniak, M.A. and de Souza, R.J. and Campbell, N.C. and Fontes, M. and Shaikh, M. and Sears, M.R. and Becker, A.B. and Mandhane, P.J. and Subbarao, P. and Turvey, S.E. and Gupta, M. and Beyene, J. and Surette, M.G. and Anand, S.S.
DOI: 10.1186/s13073-017-0421-5
2017Cesarean section, formula feeding, and infant antibiotic exposure: Separate and combined impacts on gut microbial changes in later infancy
Frontiers in Pediatrics
Yasmin, F. and Tun, H.M. and Konya, T.B. and Guttman, D.S. and Chari, R.S. and Field, C.J. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Subbarao, P. and Sears, M.R. and Scott, J.A. and Dinu, I. and Kozyrskyj, A.L. and Anand, S.S. and Azad, M.B. and Befus, A.D. and Brauer, M. and Brook, J.R. and Chen, E. and Cyr, M.M. and Daley, D. and Dell, S.D. and Denburg, J.A. and Duan, Q.L. and Eiwegger, T. and Grasemann, H. and HayGlass, K. and Hegele, R.G. and Holness, D.L. and Hystad, P. and Kobor, M. and Kollmann, T.R. and Laprise, C. and Lou, W.Y.W. and Macri, J. and Miller, G. and Moraes, T.J. and Paré, P. and Ramsey, C. and Ratjen, F. and Sandford, A. and Silverman, F. and Simons, E. and Takaro, T. and Tebbutt, S.J. and To, T.
DOI: 10.3389/fped.2017.00200
2017The importance of considering monogenic causes of autoimmunity: A somatic mutation in KRAS causing pediatric Rosai-Dorfman syndrome and systemic lupus erythematosus
Clinical Immunology
Ragotte, R.J. and Dhanrajani, A. and Pleydell-Pearce, J. and Del Bel, K.L. and Tarailo-Graovac, M. and van Karnebeek, C. and Terry, J. and Senger, C. and McKinnon, M.L. and Seear, M. and Prendiville, J.S. and Tucker, L.B. and Houghton, K. and Cabral, D.A. and Guzman, J. and Petty, R.E. and Brown, K.L. and Tekano, J. and Wu, J. and Morishita, K.A. and Turvey, S.E.
DOI: 10.1016/j.clim.2016.12.006
2017Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming
Immunity
Vaeth, M. and Maus, M. and Klein-Hessling, S. and Freinkman, E. and Yang, J. and Eckstein, M. and Cameron, S. and Turvey, S.E. and Serfling, E. and Berberich-Siebelt, F. and Possemato, R. and Feske, S.
DOI: 10.1016/j.immuni.2017.09.003
2017Monogenic immune disorders and severe atopic disease
Nature Genetics
Biggs, C.M. and Lu, H.Y. and Turvey, S.E.
DOI: 10.1038/ng.3925
2017Chronic Mucocutaneous Candidiasis, ACT1 Deficiency
Encyclopedia of Medical Immunology
Catherine M. Biggs and Stuart E. Turvey
DOI: 10.1007/978-1-4614-9209-2_63-1
2017Cystic Fibrosis: Modifier Genes
eLS
Aabida Saferali and Stuart E Turvey and Andrew J Sandford
DOI: 10.1002/9780470015902.a0020233
09/2016A Family History of Psoriasis in a First-degree Relative in Children with JIA: to Include or Exclude?
Chan MO and Petty RE and Guzman J and ReACCh-Out Investigators
DOI: 10.3899/jrheum.150555
PubMed: 26980584
05/2016Cognitive Enhancement in Infants Associated with Increased Maternal Fruit Intake During Pregnancy: Results from a Birth Cohort Study with Validation in an Animal Model
EBioMedicine
Bolduc, F.V. and Lau, A. and Rosenfelt, C.S. and Langer, S. and Wang, N. and Smithson, L. and Lefebvre, D. and Alexander, R.T. and Dickson, C.T. and Li, L. and Becker, A.B. and Subbarao, P. and Turvey, S.E. and Pei, J. and Sears, M.R. and Mandhane, P.J.
DOI: 10.1016/j.ebiom.2016.04.025
2016Gene expression deconvolution for uncovering molecular signatures in response to therapy in juvenile idiopathic arthritis
PLoS ONE
Cui, A. and Quon, G. and Rosenberg, A.M. and Yeung, R.S.M. and Morris, Q. and Dancey, P. and Huber, A. and Lang, B. and Ramsey, S. and Stringer, E. and Chetaille, A.-L. and Boire, G. and Campillo, S. and Chï??deville, G. and Scuccimarri, R. and Duffy, C. and Duffy, K.W. and Gibbon, M. and Jurencak, R. and Roth, J. and Benseler, S. and Cameron, B. and Feldman, B. and Laxer, R. and Schneider, R. and Spiegel, L. and Tse, S. and Oen, K. and Rezaei, E. and Matheson, L. and Ellsworth, J. and Cabral, D.A. and Guzman, J. and Houghton, K. and Petty, R. and Tucker, L.B. and Turvey, S.
DOI: 10.1371/journal.pone.0156055
2016Outcomes of respiratory syncytial virus immunoprophylaxis in infants using an abbreviated dosing regimen of palivizumab
JAMA Pediatrics
Lavoie, P.M. and Solimano, A. and Taylor, R. and Kwan, E. and Claydon, J. and Turvey, S.E. and Marr, N.
DOI: 10.1001/jamapediatrics.2015.3235
2016Infant gut immunity: A preliminary study of IgA associations with breastfeeding
Journal of Developmental Origins of Health and Disease
Bridgman, S.L. and Konya, T. and Azad, M.B. and Sears, M.R. and Becker, A.B. and Turvey, S.E. and Mandhane, P.J. and Subbarao, P. and Sears, M.R. and Subbarao, P. and Allen, R. and Anand, S.S. and Becker, A.B. and Befus, A.D. and Brauer, M. and Brook, J.R. and Chen, E. and Cyr, M. and Daley, D. and Dell, S. and Denburg, J.A. and Elliott, S. and Grasemann, H. and HayGlass, K. and Hegele, R. and Holness, D.L. and Lou, W.Y.W. and Kobor, M.S. and Kollman, T.R. and Kozyrskyj, A.L. and Laprise, C. and Larché, M. and MacRi, J. and Mandhane, P.M. and Miller, G. and Moqbel, R. and Moraes, T. and Paré, P.D. and Ramsey, C. and Ratjen, F. and Sandford, A. and Scott, J.A. and Scott, J. and Silverman, F. and Takaro, T. and Tang, P. and Tebbutt, S. and To, T. and Scott, J.A. and Field, C.J. and Kozyrskyj, A.L.
DOI: 10.1017/S2040174415007862
2016Endosomal pH modulation by peptide-gold nanoparticle hybrids enables potent anti-inflammatory activity in phagocytic immune cells
Biomaterials
Yang, H. and Kozicky, L. and Saferali, A. and Fung, S.-Y. and Afacan, N. and Cai, B. and Falsafi, R. and Gill, E. and Liu, M. and Kollmann, T.R. and Hancock, R.E.W. and Sly, L.M. and Turvey, S.E.
DOI: 10.1016/j.biomaterials.2016.09.032
2016Association between artificially sweetened beverage consumption during pregnancy and infant body mass index
JAMA Pediatrics
Azad, M.B. and Sharma, A.K. and De Souza, R.J. and Dolinsky, V.W. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Subbarao, P. and Lefebvre, D.L. and Sears, M.R. and Anand, S. and Cyr, M. and Denburg, J.A. and Larché, M. and Macri, J. and Dell, S. and Grasemann, H. and Hegele, R. and Moraes, T.J. and Ratjen, F. and To, T. and Allen, R. and Takaro, T.K. and HayGlass, K.T. and Moqbel, R. and Ramsey, C. and Simons, E. and Befus, A.D. and Kozyrskyj, A.L. and Brauer, M. and Daley, D. and Kobor, M.S. and Kollmann, T.R. and Paré, P.D. and Sandford, A. and Tang, P. and Tebbutt, S. and Brook, J.R. and Holness, D.L. and Wendy Lou, W.Y. and Scott, J. and Scott, J.A. and Silverman, F. and Chen, E. and Miller, G.E. and Elliott, S. and Laprise, C.
DOI: 10.1001/jamapediatrics.2016.0301
2016Exome sequencing and the management of neurometabolic disorders
New England Journal of Medicine
Tarailo-Graovac, M. and Shyr, C. and Ross, C.J. and Horvath, G.A. and Salvarinova, R. and Ye, X.C. and Zhang, L.-H. and Bhavsar, A.P. and Lee, J.J.Y. and Drögemöller, B.I. and Abdelsayed, M. and Alfadhel, M. and Armstrong, L. and Baumgartner, M.R. and Burda, P. and Connolly, M.B. and Cameron, J. and Demos, M. and Dewan, T. and Dionne, J. and Evans, A.M. and Friedman, J.M. and Garber, I. and Lewis, S. and Ling, J. and Mandal, R. and Mattman, A. and McKinnon, M. and Michoulas, A. and Metzger, D. and Ogunbayo, O.A. and Rakic, B. and Rozmus, J. and Ruben, P. and Sayson, B. and Santra, S. and Schultz, K.R. and Selby, K. and Shekel, P. and Sirrs, S. and Skrypnyk, C. and Superti-Furga, A. and Turvey, S.E. and Van Allen, M.I. and Wishart, D. and Wu, J. and Wu, J. and Zafeiriou, D. and Kluijtmans, L. and Wevers, R.A. and Eydoux, P. and Lehman, A.M. and Vallance, H. and Stockler-Ipsiroglu, S. and Sinclair, G. and Wasserman, W.W. and Van Karnebeek, C.D.
DOI: 10.1056/NEJMoa1515792
2016A humanized microbiota mouse model of ovalbumin-induced lung inflammation
Gut Microbes
Arrieta, M.-C. and Sadarangani, M. and Brown, E.M. and Russell, S.L. and Nimmo, M. and Dean, J. and Turvey, S.E. and Chan, E.S. and Finlay, B.B.
DOI: 10.1080/19490976.2016.1182293
2016Successful clinical treatment and functional immunological normalization of human MALT1 deficiency following hematopoietic stem cell transplantation
Clinical Immunology
Rozmus, J. and McDonald, R. and Fung, S.-Y. and Del Bel, K.L. and Roden, J. and Senger, C. and Schultz, K.R. and McKinnon, M.L. and Davis, J. and Turvey, S.E.
DOI: 10.1016/j.clim.2016.04.011
2016AllerGen’s 8th research conference.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
2016The risk and nature of flares in juvenile idiopathic arthritis: Results from the ReACCh-Out cohort
Annals of the Rheumatic Diseases
Guzman, J. and Oen, K. and Huber, A.M. and Duffy, K.W. and Boire, G. and Shiff, N. and Berard, R.A. and Levy, D.M. and Stringer, E. and Scuccimarri, R. and Morishita, K. and Johnson, N. and Cabral, D.A. and Rosenberg, A.M. and Larché, M. and Dancey, P. and Petty, R.E. and Laxer, R.M. and Silverman, E. and Miettunen, P. and Chetaille, A.-L. and Haddad, E. and Houghton, K. and Spiegel, L. and Turvey, S.E. and Schmeling, H. and Lang, B. and Ellsworth, J. and Ramsey, S.E. and Bruns, A. and Roth, J. and Campillo, S. and Benseler, S. and Chédeville, G. and Schneider, R. and Tse, S.M.L. and Bolaria, R. and Gross, K. and Feldman, B. and Feldman, D. and Cameron, B. and Jurencak, R. and Dorval, J. and LeBlanc, C. and St. Cyr, C. and Gibbon, M. and Yeung, R.S.M. and Duffy, C.M. and Tucker, L.B.
DOI: 10.1136/annrheumdis-2014-207164
2016Proceedings of the Canadian society of allergy and clinical immunology annual scientific meeting 2015.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
2016Presence of Archaea in the Indoor Environment and Their Relationships with Housing Characteristics
Microbial Ecology
Pakpour, S. and Scott, J.A. and Turvey, S.E. and Brook, J.R. and Takaro, T.K. and Sears, M.R. and Klironomos, J.
DOI: 10.1007/s00248-016-0767-z
2016Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: A prospective cohort study
BJOG: An International Journal of Obstetrics and Gynaecology
Azad, M.B. and Konya, T. and Persaud, R.R. and Guttman, D.S. and Chari, R.S. and Field, C.J. and Sears, M.R. and Mandhane, P.J. and Turvey, S.E. and Subbarao, P. and Becker, A.B. and Scott, J.A. and Kozyrskyj, A.L.
DOI: 10.1111/1471-0528.13601
2016Shifts in Lachnospira and Clostridium sp. in the 3-month stool microbiome are associated with preschool age asthma
Clinical Science
Stiemsma, L.T. and Arrieta, M.-C. and Dimitriu, P.A. and Cheng, J. and Thorson, L. and Lefebvre, D.L. and Azad, M.B. and Subbarao, P. and Mandhane, P. and Becker, A. and Sears, M.R. and Kollmann, T.R. and Mohn, W.W. and Finlay, B.B. and Turvey, S.E.
DOI: 10.1042/CS20160349
2016IRAK-4 deficiency as a cause for familial fatal invasive infection by Streptococcus pneumoniae
Clinical Immunology
Grazioli, S. and Hamilton, S.J. and McKinnon, M.L. and Del Bel, K.L. and Hoang, L. and Cook, V.E. and Hildebrand, K.J. and Junker, A.K. and Turvey, S.E.
DOI: 10.1016/j.clim.2015.12.007
2016High fecal IgA is associated with reduced Clostridium difficile colonization in infants
Microbes and Infection
Bridgman, S.L. and Konya, T. and Azad, M.B. and Guttman, D.S. and Sears, M.R. and Becker, A.B. and Turvey, S.E. and Mandhane, P.J. and Subbarao, P. and Scott, J.A. and Field, C.J. and Kozyrskyj, A.L.
DOI: 10.1016/j.micinf.2016.05.001
2016Harmonization of food-frequency questionnaires and dietary pattern analysis in 4 ethnically diverse birth cohorts
Journal of Nutrition
de Souza, R.J. and Zulyniak, M.A. and Desai, D. and Shaikh, M.R. and Campbell, N.C. and Lefebvre, D.L. and Gupta, M. and Wilson, J. and Wahi, G. and Atkinson, S.A. and Teo, K.K. and Subbarao, P. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Sears, M.R. and Anand, S.S. and Beyene, J. and Denburg, J.A. and McDonald, S. and Mente, A. and Meyre, D. and Morrison, K. and Pare, G. and Surette, M.
DOI: 10.3945/jn.116.236729
2016Activity of SHIP, Which Prevents Expression of Interleukin 1ß, Is Reduced in Patients with Crohn's Disease
Gastroenterology
Ngoh, E.N. and Weisser, S.B. and Lo, Y. and Kozicky, L.K. and Jen, R. and Brugger, H.K. and Menzies, S.C. and McLarren, K.W. and Nackiewicz, D. and Van Rooijen, N. and Jacobson, K. and Ehses, J.A. and Turvey, S.E. and Sly, L.M.
DOI: 10.1053/j.gastro.2015.09.049
2016Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function
Journal of Clinical Investigation
Concepcion, A.R. and Vaeth, M. and Wagner, L.E. and Eckstein, M. and Hecht, L. and Jun, Y. and Crottes, D. and Seidl, M. and Shin, H.P. and Weidinger, C. and Cameron, S. and Turvey, S.E. and Issekutz, T. and Meyts, I. and Lacruz, R.S. and Cuk, M. and Yule, D.I. and Feske, S.
DOI: 10.1172/JCI89056
2016HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis.
Ombrello MJ and Remmers EF and Tachmazidou I and Grom A and Foell D and Haas JP and Martini A and Gattorno M and Özen S and Prahalad S and Zeft AS and Bohnsack JF and Mellins ED and Ilowite NT and Russo R and Len C and Hilario MO and Oliveira S and Yeung RS and Rosenberg A
DOI: 10.1073/pnas.1520779112
PubMed: 26598658
12/2015The serine protease autotransporter Pic modulates Citrobacter rodentium pathogenesis and its innate recognition by the host
Infection and Immunity
Bhullar, K. and Zarepour, M. and Yu, H. and Yang, H. and Croxen, M. and Stahl, M. and Finlay, B.B. and Turvey, S.E. and Vallance, B.A.
DOI: 10.1128/IAI.00025-15
2015The hygiene hypothesis: current perspectives and future therapies.
Stiemsma LT and Reynolds LA and Turvey SE and Finlay BB
DOI: 10.2147/itt.s61528
PubMed: 27471720
2015The canadian healthy infant longitudinal development birth cohort study: Biological samples and biobanking
Paediatric and Perinatal Epidemiology
Moraes, T.J. and Lefebvre, D.L. and Chooniedass, R. and Becker, A.B. and Brook, J.R. and Denburg, J. and Hayglass, K.T. and Hegele, R.G. and Kollmann, T.R. and Macri, J. and Mandhane, P.J. and Scott, J.A. and Subbarao, P. and Takaro, T.K. and Turvey, S.E. and Duncan, J.D. and Sears, M.R. and Befus, A.D.
DOI: 10.1111/ppe.12161
2015The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study: Assessment of environmental exposures
Journal of Exposure Science and Environmental Epidemiology
Takaro, T.K. and Scott, J.A. and Allen, R.W. and Anand, S.S. and Becker, A.B. and Befus, A.D. and Brauer, M. and Duncan, J. and Lefebvre, D.L. and Lou, W. and Mandhane, P.J. and McLean, K.E. and Miller, G. and Sbihi, H. and Shu, H. and Subbarao, P. and Turvey, S.E. and Wheeler, A.J. and Zeng, L. and Sears, M.R. and Brook, J.R.
DOI: 10.1038/jes.2015.7
2015Infant gut microbiota and food sensitization: Associations in the first year of life
Clinical and Experimental Allergy
Azad, M.B. and Konya, T. and Guttman, D.S. and Field, C.J. and Sears, M.R. and Hayglass, K.T. and Mandhane, P.J. and Turvey, S.E. and Subbarao, P. and Becker, A.B. and Scott, J.A. and Kozyrskyj, A.L. and Allen, R. and Befus, D. and Brauer, M. and Brook, J. and Cyr, M. and Chen, E. and Daley, D. and Dell, S. and Denburg, J. and Elliott, S. and Grasemann, H. and Hegele, R. and Holness, L. and Kobor, M. and Kollmann, T. and Laprise, C. and Larché, M. and Lou, W. and Macri, J. and Miller, G. and Moqbel, R. and Moraes, T. and Paré, P. and Ramsey, C. and Ratjen, F. and Ritchie, B. and Sandford, A. and Scott, J. and Silverman, F. and Tebbutt, S. and Takaro, T. and Tang, P. and To, T.
DOI: 10.1111/cea.12487
2015Perinatal exposure to traffic-related air pollution and atopy at 1 year of age in a multi-center Canadian birth cohort study
Environmental Health Perspectives
DOI: 10.1289/ehp.1408700
2015The Canadian Healthy Infant Longitudinal Development (CHILD) study: Examining developmental origins of allergy and asthma
Thorax
Subbarao, P. and Anand, S.S. and Becker, A.B. and Befus, A.D. and Brauer, M. and Brook, J.R. and Denburg, J.A. and Hayglass, K.T. and Kobor, M.S. and Kollmann, T.R. and Kozyrskyj, A.L. and Lou, W.Y.W. and Mandhane, P.J. and Miller, G.E. and Moraes, T.J. and Pare, P.D. and Scott, J.A. and Takaro, T.K. and Turvey, S.E. and Duncan, J.M. and Lefebvre, D.L. and Sears, M.R.
DOI: 10.1136/thoraxjnl-2015-207246
2015Impaired NLRP3 inflammasome activity during fetal development regulates IL-1ß production in human monocytes
European Journal of Immunology
Sharma, A.A. and Jen, R. and Kan, B. and Sharma, A. and Marchant, E. and Tang, A. and Gadawski, I. and Senger, C. and Skoll, A. and Turvey, S.E. and Sly, L.M. and Côté, H.C.F. and Lavoie, P.M.
DOI: 10.1002/eji.201444707
2015The Crohn's disease-associated polymorphism in ATG16L1 (rs2241880) reduces SHIP gene expression and activity in human subjects
Genes and Immunity
Ngoh, E.N. and Brugger, H.K. and Monajemi, M. and Menzies, S.C. and Hirschfeld, A.F. and Del Bel, K.L. and Jacobson, K. and Lavoie, P.M. and Turvey, S.E. and Sly, L.M.
DOI: 10.1038/gene.2015.30
2015Amino Acid-Dependent Attenuation of Toll-like Receptor Signaling by Peptide-Gold Nanoparticle Hybrids
ACS Nano
Yang, H. and Fung, S.-Y. and Xu, S. and Sutherland, D.P. and Kollmann, T.R. and Liu, M. and Turvey, S.E.
DOI: 10.1021/nn505634h
2015The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-¿ B signalling
Nature Communications
Klein, T. and Fung, S.-Y. and Renner, F. and Blank, M.A. and Dufour, A. and Kang, S. and Bolger-Munro, M. and Scurll, J.M. and Priatel, J.J. and Schweigler, P. and Melkko, S. and Gold, M.R. and Viner, R.I. and Régnier, C.H. and Turvey, S.E. and Overall, C.M.
DOI: 10.1038/ncomms9777
2015The outcomes of juvenile idiopathic arthritis in children managed with contemporary treatments: Results from the reacch-out cohort
Annals of the Rheumatic Diseases
Guzman, J. and Oen, K. and Tucker, L.B. and Huber, A.M. and Shiff, N. and Boire, G. and Scuccimarri, R. and Berard, R. and Tse, S.M.L. and Morishita, K. and Stringer, E. and Johnson, N. and Levy, D.M. and Duffy, K.W. and Cabral, D.A. and Rosenberg, A.M. and Larché, M. and Dancey, P. and Petty, R.E. and Laxer, R.M. and Silverman, E. and Miettunen, P. and Chetaille, A.-L. and Haddad, E. and Houghton, K. and Spiegel, L. and Turvey, S.E. and Schmeling, H. and Lang, B. and Ellsworth, J. and Ramsey, S. and Bruns, A. and Campillo, S. and Benseler, S. and Chédeville, G. and Schneider, R. and Yeung, R. and Duffy, C.M.
DOI: 10.1136/annrheumdis-2014-205372
2015Early infancy microbial and metabolic alterations affect risk of childhood asthma
Science Translational Medicine
Arrieta, M.-C. and Stiemsma, L.T. and Dimitriu, P.A. and Thorson, L. and Russell, S. and Yurist-Doutsch, S. and Kuzeljevic, B. and Gold, M.J. and Britton, H.M. and Lefebvre, D.L. and Subbarao, P. and Mandhane, P. and Becker, A. and McNagny, K.M. and Sears, M.R. and Kollmann, T. and Mohn, W.W. and Turvey, S.E. and Finlay, B.B.
DOI: 10.1126/scitranslmed.aab2271
2015Combined immunodeficiency associated with homozygous MALT1 mutations
Journal of Allergy and Clinical Immunology
McKinnon, M.L. and Rozmus, J. and Fung, S.-Y. and Hirschfeld, A.F. and Del Bel, K.L. and Thomas, L. and Marr, N. and Martin, S.D. and Marwaha, A.K. and Priatel, J.J. and Tan, R. and Senger, C. and Tsang, A. and Prendiville, J. and Junker, A.K. and Seear, M. and Schultz, K.R. and Sly, L.M. and Holt, R.A. and Patel, M.S. and Friedman, J.M. and Turvey, S.E.
DOI: 10.1016/j.jaci.2013.10.045
2014Optimizing pediatric venipuncture: Ensuring successful blood sample collection with minimal stress and pain
Allergy, Asthma and Clinical Immunology
Mauro, M.A. and Warner, L. and Mamonluk, R. and Turvey, S.E.
DOI: 10.1186/1710-1492-10-S2-A59
2014Attenuation of respiratory syncytial virus-induced and RIG-I-dependent type I IFN responses in human neonates and very young children
Journal of Immunology
Marr, N. and Wang, T.-I. and Kam, S.H.Y. and Hu, Y.S. and Sharma, A.A. and Lam, A. and Markowski, J. and Solimano, A. and Lavoie, P.M. and Turvey, S.E.
DOI: 10.4049/jimmunol.1302007
2014A Novel Mouse Model of Campylobacter jejuni Gastroenteritis Reveals Key Pro-inflammatory and Tissue Protective Roles for Toll-like Receptor Signaling during Infection
PLoS Pathogens
Stahl, M. and Ries, J. and Vermeulen, J. and Yang, H. and Sham, H.P. and Crowley, S.M. and Badayeva, Y. and Turvey, S.E. and Gaynor, E.C. and Li, X. and Vallance, B.A.
DOI: 10.1371/journal.ppat.1004264
2014The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency
Journal of Allergy and Clinical Immunology
Turvey, S.E. and Durandy, A. and Fischer, A. and Fung, S.-Y. and Geha, R.S. and Gewies, A. and Giese, T. and Greil, J. and Keller, B. and McKinnon, M.L. and Neven, B. and Rozmus, J. and Ruland, J. and Snow, A.L. and Stepensky, P. and Warnatz, K.
DOI: 10.1016/j.jaci.2014.06.015
2014Hierarchical maturation of innate immune defences in very preterm neonates
Neonatology
Sharma, A.A. and Jen, R. and Brant, R. and Ladd, M. and Huang, Q. and Skoll, A. and Senger, C. and Turvey, S.E. and Marr, N. and Lavoie, P.M.
DOI: 10.1159/000358550
2014Optimizing subject retention in a longitudinal birth cohort study: lessons learned from the Vancouver site of the CHILD Study.
Warner L and Mauro MA and Menzies S and Assadian G and Mamonluk R and Lepine C and Turvey SE
DOI: 10.1186/1710-1492-10-s1-a20
2014Dual proteolytic pathways govern glycolysis and immune competence
Cell
Lu, W. and Zhang, Y. and McDonald, D.O. and Jing, H. and Carroll, B. and Robertson, N. and Zhang, Q. and Griffin, H. and Sanderson, S. and Lakey, J.H. and Morgan, N.V. and Reynard, L.N. and Zheng, L. and Murdock, H.M. and Turvey, S.E. and Hackett, S.J. and Prestidge, T. and Hall, J.M. and Cant, A.J. and Matthews, H.F. and Koref, M.F.S. and Simon, A.K. and Korolchuk, V.I. and Lenardo, M.J. and Hambleton, S. and Su, H.C.
DOI: 10.1016/j.cell.2014.12.001
2014Associations between bacterial communities of house dust and infant gut
Environmental Research
Konya, T. and Koster, B. and Maughan, H. and Escobar, M. and Azad, M.B. and Guttman, D.S. and Sears, M.R. and Becker, A.B. and Brook, J.R. and Takaro, T.K. and Kozyrskyj, A.L. and Scott, J.A. and Allen, R. and Befus, D. and Brauer, M. and Cyr, M. and Chen, E. and Daley, D. and Dell, S. and Denburg, J. and Elliott, S. and Grasemann, H. and HayGlass, K. and Hegele, R. and Holness, L. and Kobor, M. and Kollmann, T. and Laprise, C. and Larché, M. and Lou, W. and Macri, J. and Mandhane, P. and Miller, G. and Moqbel, R. and Moraes, T. and Paré, P. and Ramsey, C. and Ratjen, F. and Ritchie, B. and Sandford, A. and Scott, J. and Silverman, F. and Subbarao, P. and Tebbutt, S. and Tang, P. and To, T. and Turvey, S.
DOI: 10.1016/j.envres.2014.02.005
2014Assessment of genetic associations between common single nucleotide polymorphisms in RIG-I-like receptor and IL-4 signaling genes and severe respiratory syncytial virus infection in children: A candidate gene case-control study
PLoS ONE
Marr, N. and Hirschfeld, A.F. and Lam, A. and Wang, S. and Lavoie, P.M. and Turvey, S.E.
DOI: 10.1371/journal.pone.0100269
2014An antibiotic-altered microbiota provides fuel for the enteric foe
Cell Research
Stiemsma, L.T. and Turvey, S.E. and Finlay, B.B.
DOI: 10.1038/cr.2013.142
2014Unbiased screening of marine sponge extracts for antiinflammatory agents combined with chemical genomics identifies girolline as an inhibitor of protein synthesis
ACS Chemical Biology
Fung, S.-Y. and Sofiyev, V. and Schneiderman, J. and Hirschfeld, A.F. and Victor, R.E. and Woods, K. and Piotrowski, J.S. and Deshpande, R. and Li, S.C. and De Voogd, N.J. and Myers, C.L. and Boone, C. and Andersen, R.J. and Turvey, S.E.
DOI: 10.1021/cb400740
2014The early life gut microbiota and atopic disease
Allergy, Asthma and Clinical Immunology
Stiemsma, L.T. and Arrieta, M.-C. and Dimitriu, P.A. and Thorson, L. and Yurist, S. and Brandt, R. and Lefebvre, D.L. and Subbarao, P. and Mandhane, P. and Becker, A. and Sears, M. and Kollmann, T. and Mohn, W.W. and Finlay, B.B. and Turvey, S.E. and the CHILD Study Investigators
DOI: 10.1186/1710-1492-10-S2-A63
2014Comparison of questionnaire responses with biomarkers of tobacco smoke exposure in a Canadian birth cohort at three months of age.
McLean K and Lanphear B and Wheeler AJ and Brook J and Scott J and Allen R and Brauer M and Sears M and Subbarao P and Turvey S and Becker A and Mandhane P and Takaro T
DOI: 10.1186/1710-1492-10-s1-a60
2014The impact of the intestinal microbiome on human immune development and atopic disease.
Thomas LT and Arrieta M and Dimitriu PA and Thorson L and Mohn WW and Finlay BB and Turvey SE
DOI: 10.1186/1710-1492-10-s1-a63
2014Limitation of TREC-based newborn screening for ZAP70 Severe Combined Immunodeficiency
Clinical Immunology
Grazioli, S. and Bennett, M. and Hildebrand, K.J. and Vallance, H. and Turvey, S.E. and Junker, A.K.
DOI: 10.1016/j.clim.2014.04.015
2014Current concepts: Host-pathogen interactions in cystic fibrosis airways disease
European Respiratory Review
Tang, A.C. and Turvey, S.E. and Alves, M.P. and Regamey, N. and Tümmler, B. and Hartl, D.
DOI: 10.1183/09059180.00006113
2014Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months.
Azad MB and Konya T and Maughan H and Guttman DS and Field CJ and Chari RS and Sears MR and Becker AB and Scott JA and Kozyrskyj AL and CHILD Study Investigators
DOI: 10.1503/cmaj.121189
PubMed: 23401405
03/2013A new exposure metric for traffic-related air pollution? An analysis of determinants of hopanes in settled indoor house dust
Environmental Health: A Global Access Science Source
Sbihi, H. and Brook, J.R. and Allen, R.W. and Curran, J.H. and Dell, S. and Mandhane, P. and Scott, J.A. and Sears, M.R. and Subbarao, P. and Takaro, T.K. and Turvey, S.E. and Wheeler, A.J. and Brauer, M.
DOI: 10.1186/1476-069X-12-48
2013Amino acid structure determines the immune responses generated by peptide-gold nanoparticle hybrids
Particle and Particle Systems Characterization
Yang, H. and Zhou, Y. and Fung, S.-Y. and Wu, L. and Tsai, K. and Tan, R. and Turvey, S.E. and Machuca, T. and De Perrot, M. and Waddell, T.K. and Liu, M.
DOI: 10.1002/ppsc.201300213
2013Human primary immunodeficiencies causing defects in innate immunity
Current Opinion in Allergy and Clinical Immunology
Wong, T. and Yeung, J. and Hildebrand, K.J. and Junker, A.K. and Turvey, S.E.
DOI: 10.1097/ACI.0000000000000010
2013Pathogen recognition receptor crosstalk in respiratory syncytial virus sensing: A host and cell type perspective
Trends in Microbiology
Marr, N. and Turvey, S.E. and Grandvaux, N.
DOI: 10.1016/j.tim.2013.08.006
2013Neonatal Pain-Related Stress and NFKBIA Genotype Are Associated with Altered Cortisol Levels in Preterm Boys at School Age
PLoS ONE
Grunau, R.E. and Cepeda, I.L. and Chau, C.M.Y. and Brummelte, S. and Weinberg, J. and Lavoie, P.M. and Ladd, M. and Hirschfeld, A.F. and Russell, E. and Koren, G. and Van Uum, S. and Brant, R. and Turvey, S.E.
DOI: 10.1371/journal.pone.0073926
2013Severe combined immunodeficiency (SCID) in Canadian children: A national surveillance study
Journal of Clinical Immunology
Rozmus, J. and Junker, A. and Thibodeau, M.L. and Grenier, D. and Turvey, S.E. and Yacoub, W. and Embree, J. and Haddad, E. and Langley, J.M. and Ramsingh, R.M. and Singh, V.-A. and Long, R. and Schultz, K.R.
DOI: 10.1007/s10875-013-9952-8
2013Association of common single-nucleotide polymorphisms in innate immune genes with differences in TLR-induced cytokine production in neonates
Genes and Immunity
Cho, P. and Gelinas, L. and Corbett, N.P. and Tebbutt, S.J. and Turvey, S.E. and Fortuno, E.S. and Kollmann, T.R.
DOI: 10.1038/gene.2013.5
2013Functional genetic variation in NFKBIA and susceptibility to childhood asthma, bronchiolitis, and bronchopulmonary dysplasia
Journal of Immunology
Ali, S. and Hirschfeld, A.F. and Mayer, M.L. and Fortuno III, E.S. and Corbett, N. and Kaplan, M. and Wang, S. and Schneiderman, J. and Fjell, C.D. and Yan, J. and Akhabir, L. and Aminuddin, F. and Marr, N. and Lacaze-Masmonteil, T. and Hegele, R.G. and Becker, A. and Chan-Yeung, M. and Hancock, R.E.W. and Kollmann, T.R. and Daley, D. and Sandford, A.J. and Lavoie, P.M. and Turvey, S.E.
DOI: 10.4049/jimmunol.1201015
2013Functional analysis of the impact of ORMDL3 expression on inflammation and activation of the unfolded protein response in human airway epithelial cells
Allergy, Asthma and Clinical Immunology
Hsu, K.J. and Turvey, S.E.
DOI: 10.1186/1710-1492-9-4
2013Rescue of dysfunctional autophagy attenuates hyperinflammatory responses from cystic fibrosis cells
Journal of Immunology
Mayer, M.L. and Blohmke, C.J. and Falsafi, R. and Fjell, C.D. and Madera, L. and Turvey, S.E. and Hancock, R.E.W.
DOI: 10.4049/jimmunol.1201404
2013IL-4Ra on CD4+ T cells plays a pathogenic role in respiratory syncytial virus reinfection in mice infected initially as neonates
Journal of Leukocyte Biology
You, D. and Marr, N. and Saravia, J. and Shrestha, B. and Lee, G.I. and Turvey, S.E. and Brombacher, F. and Herbert, D.R. and Cormier, S.A.
DOI: 10.1189/jlb.1012498
2013Do adult disease severity subclassifications predict use of cyclophosphamide in children with ANCA-associated vasculitis? An analysis of ARChiVe study treatment decisions.
Morishita K and Guzman J and Chira P and Muscal E and Zeft A and Klein-Gitelman M and Uribe AG and Abramson L and Benseler SM and Eberhard A and Ede K and Hashkes PJ and Hersh AO and Higgins G and Imundo LF and Jung L and Kim S and Kingsbury DJ and Lawson EF and Lee T
DOI: 10.3899/jrheum.120299
PubMed: 22859342
10/2012Increased sensitivity of the European medicines agency algorithm for classification of childhood granulomatosis with polyangiitis.
The Journal of rheumatology
DOI: 10.3899/jrheum.111352
PubMed: 22589257
08/2012Assessing the performance of the Birmingham Vasculitis Activity Score at diagnosis for children with antineutrophil cytoplasmic antibody-associated vasculitis in A Registry for Childhood Vasculitis (ARChiVe).
Morishita K and Li SC and Muscal E and Spalding S and Guzman J and Uribe A and Abramson L and Baszis K and Benseler S and Bowyer S and Campillo S and Chira P and Hersh AO and Higgins G and Eberhard A and Ede K and Imundo L and Jung L and Kim S and Kingsbury DJ
DOI: 10.3899/jrheum.111030
PubMed: 22337238
05/2012Staphylococcus aureus nasal septal abscess complicated by extradural abscess in an infant.
Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
Tan NW and Turvey SE and Byrne AT and Ludemann JP and Kollmann TR
PubMed: 22498276
02/2012Influence of common non-synonymous toll-like receptor 4 polymorphisms on bronchopulmonary dysplasia and prematurity in human infants
PLoS ONE
Lavoie, P.M. and Ladd, M. and Hirschfeld, A.F. and Huusko, J. and Mahlman, M. and Speert, D.P. and Hallman, M. and Lacaze-Masmonteil, T. and Turvey, S.E.
DOI: 10.1371/journal.pone.0031351
2012Successful approach to treatment of helicobacter bilis infection in x-linked agammaglobulinemia
Journal of Clinical Immunology
Turvey, S.E. and Leo, S.H. and Boos, A. and Deans, G.D. and Prendiville, J. and Crawford, R.I. and Senger, C. and Conley, M.E. and Tilley, P. and Junker, A. and Janz, L. and Azana, R. and Hoang, L. and Morton, T.L.
DOI: 10.1007/s10875-012-9750-8
2012Inflammasome-mediated IL-1ß production in humans with cystic fibrosis
PLoS ONE
Tang, A. and Sharma, A. and Jen, R. and Hirschfeld, A.F. and Chilvers, M.A. and Lavoie, P.M. and Turvey, S.E.
DOI: 10.1371/journal.pone.0037689
2012Staphylococcus aureus nasal septal abscess complicated by extradural abscess in an infant
Journal of Otolaryngology - Head and Neck Surgery
Tan, N.W.H. and Turvey, S.E. and Byrne, A.T. and Ludemann, J.P. and Kollmann, T.R.
DOI: 10.2310/7070.2011.110136
2012Atypical activation of the unfolded protein response in cystic fibrosis airway cells contributes to p38 MAPK-mediated innate immune responses
Journal of Immunology
Blohmke, C.J. and Mayer, M.L. and Tang, A.C. and Hirschfeld, A.F. and Fjell, C.D. and Sze, M.A. and Falsafi, R. and Wang, S. and Hsu, K. and Chilvers, M.A. and Hogg, J.C. and Hancock, R.E.W. and Turvey, S.E.
DOI: 10.4049/jimmunol.1103661
2012Role of human TLR4 in respiratory syncytial virus-induced NF-¿B activation, viral entry and replication
Innate Immunity
Marr, N. and Turvey, S.E.
DOI: 10.1177/1753425912444479
2012Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients
Journal of Clinical Investigation
Gaglia, J.L. and Guimaraes, A.R. and Harisinghani, M. and Turvey, S.E. and Jackson, R. and Benoist, C. and Mathis, D. and Weissleder, R.
DOI: 10.1172/JCI44339
2011Variables to be controlled in the assessment of blood innate immune responses to Toll-like receptor stimulation
Journal of Immunological Methods
Blimkie, D. and Fortuno, E.S. and Yan, H. and Cho, P. and Ho, K. and Turvey, S.E. and Marchant, A. and Goriely, S. and Kollmann, T.R.
DOI: 10.1016/j.jim.2011.01.009
2011Potential sources of phthalate exposure in a Vancouver birth cohort at three months of age
12th International Conference on Indoor Air Quality and Climate 2011
Shu, H. and Allen, R. and Brauer, M. and Rousseau, R. and Takaro, T. and Turvey, S.
2011The Pseudomonas aeruginosa autoinducer 3O-C12 homoserine lactone provokes hyperinflammatory responses from cystic fibrosis airway epithelial cells
PLoS ONE
Mayer, M.L. and Sheridan, J.A. and Blohmke, C.J. and Turvey, S.E. and Hancock, R.E.W.
DOI: 10.1371/journal.pone.0016246
2011Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome
Journal of Allergy and Clinical Immunology
Woellner, C. and Gertz, E.M. and Schäffer, A.A. and Lagos, M. and Perro, M. and Glocker, E.-O. and Pietrogrande, M.C. and Cossu, F. and Franco, J.L. and Matamoros, N. and Pietrucha, B. and Heropolita?ska-Pliszka, E. and Yeganeh, M. and Moin, M. and Español, T. and Ehl, S. and Gennery, A.R. and Abinun, M. and Breborowicz, A. and Niehues, T. and Kilic, S.S. and Junker, A. and Turvey, S.E. and Plebani, A. and Sánchez, B. and Garty, B.-Z. and Pignata, C. and Cancrini, C. and Litzman, J. and Sanal, O. and Baumann, U. and Bacchetta, R. and Hsu, A.P. and Davis, J.N. and Hammarström, L. and Davies, E.G. and Eren, E. and Arkwright, P.D. and Moilanen, J.S. and Viemann, D. and Khan, S. and Maródi, L. and Cant, A.J. and Freeman, A.F. and Puck, J.M. and Holland, S.M. and Grimbacher, B.
DOI: 10.1016/j.jaci.2009.10.059
2010Acidification-dependent activation of CD1d-restricted natural killer T cells is intact in cystic fibrosis
Immunology
Rzemieniak, S.E. and Hirschfeld, A.F. and Victor, R.E. and Chilvers, M.A. and Zheng, D. and Van Den Elzen, P. and Turvey, S.E.
DOI: 10.1111/j.1365-2567.2009.03234.x
2010Toll-like receptor signaling and pre-eclampsia
American Journal of Reproductive Immunology
Xie, F. and Turvey, S.E. and Williams, M.A. and Mor, G. and Von Dadelszen, P.
DOI: 10.1111/j.1600-0897.2009.00745.x
2010Toll-like receptor gene polymorphisms and preeclampsia risk: A case-control study and data synthesis
Hypertension in Pregnancy
Xie, F. and Hu, Y. and Speert, D.P. and Turvey, S.E. and Peng, G. and Money, D.M. and Magee, L.A. and Von Dadelszen, P.
DOI: 10.3109/10641950903242659
2010Chlamydia pneumoniae infection in preeclampsia.
Xie F and Hu Y and Magee LA and Money DM and Patrick DM and Brunham RM and Thomas E and von Dadelszen P and Toxaemia group
DOI: 10.3109/10641950903242642
PubMed: 20818953
2010Toll-like receptors 2 and 4 and the cryopyrin inflammasome in normal pregnancy and pre-eclampsia
BJOG: An International Journal of Obstetrics and Gynaecology
Xie, F. and Hu, Y. and Turvey, S.E. and Magee, L.A. and Brunham, R.M. and Choi, K.-C. and Krajden, M. and Leung, P.C.K. and Money, D.M. and Patrick, D.M. and Thomas, E. and Von Dadelszen, P.
DOI: 10.1111/j.1471-0528.2009.02428.x
2010TLR5 as an anti-inflammatory target and modifier gene in cystic fibrosis
Journal of Immunology
Blohmke, C.J. and Park, J. and Hirschfeld, A.F. and Victor, R.E. and Schneiderman, J. and Stefanowicz, D. and Chilvers, M.A. and Durie, P.R. and Corey, M. and Zielenski, J. and Dorfman, R. and Sandford, A.J. and Daley, D. and Turvey, S.E.
DOI: 10.4049/jimmunol.1001513
2010Innate immunity
Journal of Allergy and Clinical Immunology
Turvey, S.E. and Broide, D.H.
DOI: 10.1016/j.jaci.2009.07.016
2010Early outcomes and improvement of patients with juvenile idiopathic arthritis enrolled in a canadian multicenter inception cohort
Arthritis Care and Research
Oen, K. and Duffy, C.N.M. and Tse, S.M.L. and Ramsey, S. and Ellsworth, J. and Chédeville, G. and Chetaille, A.-L. and Saint-Cyr, C. and Cabral, D.A. and Spiegel, L.R. and Schneider, R. and Lang, B. and Huber, A.M. and Dancey, P. and Silverman, E. and Rosenberg, A.M. and Cameron, B. and Johnson, N. and Dorval, J. and Scuccimarri, R. and Campillo, S. and Petty, R.E. and Duffy, K.N.W. and Boire, G. and Haddad, E. and Houghton, K. and Laxer, R. and Turvey, S.E. and Miettunen, P. and Gross, K. and Guzman, J. and Benseler, S. and Feldman, B.M. and Espinosa, V. and Yeung, R.S.M. and Tucker, L.
DOI: 10.1002/acr.20044
2010Functional characterization of human variants of NFKBIA: a key regulator of immune responsiveness implicated in susceptibility to infectious and inflammatory disease.
Ali S and Hirschfeld A and Victor R and Fortuno ES and Kollmann TR and Turvey SE
DOI: 10.1186/1710-1492-6-s3-p2
2010TLR4 Asp299Gly and Thr399ile polymorphisms: No impact on human immune responsiveness to LPS or respiratory syncytial virus
PLoS ONE
Douville, R.N. and Lissitsyn, Y. and Hirschfeld, A.F. and Becker, A.B. and Kozyrskyj, A.L. and Liem, J. and Bastien, N. and Li, Y. and Victor, R.E. and Sekhon, M. and Turvey, S.E. and Hayglass, K.T.
DOI: 10.1371/journal.pone.0012087
2010Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity
Journal of Translational Medicine
Brown, K.L. and Falsafi, R. and Kum, W. and Hamill, P. and Gardy, J.L. and Davidson, D.J. and Turvey, S. and Finlay, B.B. and Speert, D.P. and Hancock, R.E.W.
DOI: 10.1186/1479-5876-8-6
2010Serious musculoskeletal infections in children receiving anti-tumor necrosis factor-a therapy: A case series
Clinical Rheumatology
Morishita, K. and Petty, R. and Cairns, R. and Bolaria, R. and Cabral, D. and Turvey, S.
DOI: 10.1007/s10067-010-1410-x
2010Ontogeny of toll-like receptor mediated cytokine responses of human blood mononuclear cells
PLoS ONE
Corbett, N.P. and Blimkie, D. and Ho, K.C. and Cai, B. and Sutherland, D.P. and Kallos, A. and Crabtree, J. and Rein-Weston, A. and Lavoie, P. and Turvey, S.E. and Hawkins, N.R. and Self, S.G. and Wilson, C.B. and Hajjar, A.M. and Fortuno, E.S. and Kollmann, T.R.
DOI: 10.1371/journal.pone.0015041
2010Potential Sources of Phthalate Exposure in a Vancouver, BC Birth Cohort at Three Months of Age
Epidemiology
Tim Takaro and Ryan Allen and Roxanne Rouseau and Michael Brauer and James Scott and Jeff Brook and Stuart Turvey
DOI: 10.1097/01.ede.0000362924.70819.3f
11/2009Predictors of early inactive disease in a juvenile idiopathic arthritis cohort: Results of a Canadian Multicenter, prospective inception cohort study
Arthritis Care and Research
Oen, K. and Tucker, L. and Huber, A.M. and Miettunen, P. and Scuccimarri, R. and Campillo, S. and Cabral, D.A. and Feldman, B.M. and Tse, S. and Chédeville, G. and Spiegel, L. and Schneider, R. and Lang, B. and Ellsworth, J. and Ramsey, S. and Dancey, P. and Silverman, E. and Chetaille, A.-L. and Cameron, B. and Johnson, N. and Dorval, J. and Petty, R.E. and Duffy, K.W. and Boire, G. and Haddad, E. and Houghton, K. and Saint-Cyr, C. and Turvey, S.E. and Benseler, S. and Cheang, M. and Yeung, R.S.M. and Duffy, C.M.
DOI: 10.1002/art.24539
2009Relative CD4 lymphopenia and a skewed memory phenotype are the main immunologic abnormalities in a child with Omenn syndrome due to homozygous RAG1-C2633T hypomorphic mutation
Clinical Immunology
McCusker, C. and Hotte, S. and Le Deist, F. and Hirschfeld, A.F. and Mitchell, D. and Nguyen, V.-H. and Gagnon, R. and Mazer, B. and Turvey, S.E. and Jabado, N.
DOI: 10.1016/j.clim.2009.01.014
2009Primary immunodeficiency diseases: A practical guide for clinicians
Postgraduate Medical Journal
Turvey, S.E. and Bonilla, F.A. and Junker, A.K.
DOI: 10.1136/pgmj.2009.080630
2009Optimizing outcomes of hematopoietic stem cell transplantation for severe combined immunodeficiency
Clinical Immunology
Cuvelier, G.D.E. and Schultz, K.R. and Davis, J. and Hirschfeld, A.F. and Junker, A.K. and Tan, R. and Turvey, S.E.
DOI: 10.1016/j.clim.2009.01.003
2009Epidemiology of asthma: Risk factors for development
Expert Review of Clinical Immunology
Subbarao, P. and Becker, A. and Brook, J.R. and Daley, D. and Mandhane, P.J. and Miller, G.E. and Turvey, S.E. and Sears, M.R.
DOI: 10.1586/1744666X.5.1.77
2009Classification, presentation, and initial treatment of Wegener's granulomatosis in childhood
Arthritis and Rheumatism
Cabral, D.A. and Uribe, A.G. and Benseler, S. and O'Neil, K.M. and Hashkes, P.J. and Higgins, G. and Zeft, A.S. and Lovell, D.J. and Kingsbury, D.J. and Stevens, A. and McCurdy, D. and Chira, P. and Abramson, L. and Arkachaisri, T. and Campillo, S. and Eberhard, A. and Hersh, A.O. and Huber, A.M. and Kim, S. and Klein-Gitelman, M. and Levy, D.M. and Li, S.C. and Mason, T. and DeWitt, E.M. and Muscal, E. and Nassi, L. and Reiff, A. and Schikler, K. and Singer, N.G. and Wahezi, D. and Woodward, A. and Espinosa, V. and Guzman, J. and Houghton, K. and Malleson, P. and Petty, R. and Tucker, L. and Turvey, S. and Brooks, E.B. and Lesko, M. and Dedeoglu, F. and Fuhlbrigge, R. and Hazen, M. and Son, M.B. and Sundel, R. and Brown, D. and Shaham, B. and Cabrera, A. and Ilowite, N.T. and Hirsh, R. and Kietz, D. and Rosen, P. and Rosenkrank, M. and Torok, K. and Pachman, L. and Ali, A. and Brunner, H. and Griffin, T. and Grom, A. and Johnson, A. and Spalding, S. and Bork, D. and Ardoin, S. and Rabinovich, E. and Schanberg, L. and Wilder, R. and Lang, B.A. and Ramsey, S. and Stringer, E. and Warner, A. and Haines, K. and Kimura, Y. and Weiss, J. and Balboni, I. and Bromberg, R. and Cidon, M. and Frankovich, J. and Gerstbacher, D. and Hsu, J.J. and Lee, T. and Park, J.L. and Sandborg, C. and Song, S. and Reed, A. and Chédeville, G. and Duffy, C. and Duffy, K. and Scuccimarri, R. and Gibbon, M. and Eichenfield, A. and Imundo, L. and Batres, C. and Bowyer, S. and Ballinger, S. and Klausmeier, T. and Hudgins, A. and Emery, H. and Hayward, K. and Inman, C. and Ringold, S. and Shaw, E. and Torgerson, T. and Turner, J. and Wallace, C. and Wargula, J. and Halford, S. and Myones, B.L. and Punaro, M. and Pascual, V. and von Scheven, E. and Michels, A. and Henrickson, M. and Jarvis, J. and Bonsack, J. and Prahalad, S.
DOI: 10.1002/art.24876
2009Innate immunity mediated by TLR5 as a novel antiinflammatory target for cystic fibrosis lung disease
Journal of Immunology
Blohmke, C.J. and Victor, R.E. and Hirschfeld, A.F. and Elias, I.M. and Hancock, D.G. and Lane, C.R. and Davidson, A.G.F. and Wilcox, P.G. and Smith, K.D. and Overhage, J. and Hancock, R.E.W. and Turvey, S.E.
DOI: 10.4049/jimmunol.180.11.7764
2008Commonly invasive serotypes of Streptococcus pneumoniae trigger a reduced innate immune response compared with serotypes rarely responsible for invasive infection
FEMS Immunology and Medical Microbiology
Burgess, T.S.T. and Hirschfeld, A.F. and Tyrrell, G.J. and Bettinger, J.A. and Turvey, S.E.
DOI: 10.1111/j.1574-695X.2008.00382.x
2008Common human Toll-like receptor 4 polymorphisms-Role in susceptibility to respiratory syncytial virus infection and functional immunological relevance
Clinical Immunology
Paulus, S.C. and Hirschfeld, A.F. and Victor, R.E. and Brunstein, J. and Thomas, E. and Turvey, S.E.
DOI: 10.1016/j.clim.2007.03.003
2007Prevalence of Toll-like receptor signalling defects in apparently healthy children who developed invasive pneumococcal infection
Clinical Immunology
Hirschfeld, A.F. and Bettinger, J.A. and Victor, R.E. and Davidson, D.J. and Currie, A.J. and Ansermino, J.M. and Scheifele, D.W. and Orange, J.S. and Turvey, S.E.
DOI: 10.1016/j.clim.2006.10.012
2007Toll-like receptor 4 polymorphisms and idiopathic chromosomally normal miscarriage
Human Reproduction
Hirschfeld, A.F. and Jiang, R. and Robinson, W.P. and McFadden, D.E. and Turvey, S.E.
DOI: 10.1093/humrep/del377
2007Recurrent systemic pneumococcal disease and IRAK4 deficiency [1]
Pediatric Infectious Disease Journal
Turvey, S.E. and Speert, D.P.
DOI: 10.1097/INF.0b013e318156fb93
2007Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution
Science
Nishio, J. and Gaglia, J.L. and Turvey, S.E. and Campbell, C. and Benoist, C. and Mathis, D.
DOI: 10.1126/science.1124004
2006Old challenges and new directions in pediatric rheumatology
Journal of Rheumatology
2006IRAK-4 mutation (Q293X): Rapid detection and characterization of defective post-transcriptional TLR/IL-1R responses in human myeloid and non-myeloid cells
Journal of Immunology
Davidson, D.J. and Currie, A.J. and Bowdish, D.M.E. and Brown, K.L. and Rosenberger, C.M. and Ma, R.C. and Bylund, J. and Campsall, P.A. and Puel, A. and Picard, C. and Casanova, J.-L. and Turvey, S.E. and Hancock, R.E.W. and Devon, R.S. and Speert, D.P.
DOI: 10.4049/jimmunol.177.11.8202
2006Detection of a novel nonsense mutation in the interleukin 2 receptor ¿ gene causing X-linked severe combined immunodeficiency [2]
Annals of Allergy, Asthma and Immunology
Cohen, L. and Hirschfeld, A.F. and Junker, A.K. and Davis, J. and Turvey, S.E.
2006Towards subtlety: Understanding the role of Toll-like receptor signaling in susceptibility to human infections
Clinical Immunology
Turvey, S.E. and Hawn, T.R.
DOI: 10.1016/j.clim.2006.02.003
2006Questions and answers on immunization
Paediatrics and Child Health
Paulus, S. and Turvey, S.
2006Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes
Journal of Clinical Investigation
Turvey, S.E. and Swart, E. and Denis, M.C. and Mahmood, U. and Benoist, C. and Weissleder, R. and Mathis, D.
DOI: 10.1172/JCI25048
2005Primary immune deficiencies presenting in adults: Seven years of experience from Iran
Journal of Clinical Immunology
Mansouri, D. and Adimi, P. and Mirsaedi, M. and Mansouri, N. and Tabarsi, P. and Amiri, M. and Jamaati, H.R. and Motavasseli, M. and Baghaii, N. and Cheraghvandi, A. and Rouhi, R. and Roozbahany, N.A. and Zahirifard, S. and Mohammadi, F. and Masjedi, M.R. and Velayati, A.A. and Casanova, J.L. and Speert, D.P. and Elwood, R.K. and Schellenberg, R. and Turvey, S.E.
DOI: 10.1007/s10875-005-4124-0
2005Adverse reactions to vitamin B12 injections due to benzyl alcohol sensitivity: Successful treatment with intranasal cyanocobalamin
Allergy: European Journal of Allergy and Clinical Immunology
Turvey, S.E. and Cronin, B. and Arnold, A.D. and Twarog, F.J. and Dioun, A.F.
DOI: 10.1111/j.1398-9995.2004.00507.x
2004Antibiotic desensitization for the allergic patient: 5 Years of experience and practice
Annals of Allergy, Asthma and Immunology
Turvey, S.E. and Cronin, B. and Arnold, A.D. and Dioun, A.F.
DOI: 10.1016/S1081-1206(10)61778-4
2004The Wiskott-Aldrich syndrome
Cellular and Molecular Life Sciences
Orange, J.S. and Stone, K.D. and Turvey, S.E. and Krzewski, K.
DOI: 10.1007/s00018-004-4086-z
2004Rituximab Therapy for Multisystem Autoimmune Diseases in Pediatric Patients
Journal of Pediatrics
Binstadt, B.A. and Caldas, A.M.C. and Turvey, S.E. and Weinstein, H.J. and Jackson, J. and Fuhlbrigge, R.C. and Sundel, R.P.
DOI: 10.1067/S0022-3476(03)00382-2
2003Churg-Strauss syndrome in a 7-year-old receiving montelukast and inhaled corticosteroids [1]
Annals of Allergy, Asthma and Immunology
Turvey, S.E. and Vargas, S.O. and Phipatanakuly, W.
2003Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge
Pediatric Allergy and Immunology
MacGinnitie, A.J. and Walensky, L.D. and Turvey, S.E. and Orange, J.S. and Bonilla, F.A. and Silverman, L.B. and Oettgen, H.
DOI: 10.1034/j.1399-3038.2003.00073.x
2003Differential susceptibility of heart, skin, and islet allografts to T cell-mediated rejection
Journal of Immunology
Jones, N.D. and Turvey, S.E. and Van Maurik, A. and Hara, M. and Kingsley, C.I. and Smith, C.H. and Mellor, A.L. and Morris, P.J. and Wood, K.J.
DOI: 10.4049/jimmunol.166.4.2824
2001Atopic diseases of childhood
Current Opinion in Pediatrics
Turvey, S.E.
DOI: 10.1097/00008480-200110000-00017
2001IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo
Journal of Immunology
Hara, M. and Kingsley, C.I. and Niimi, M. and Read, S. and Turvey, S.E. and Bushell, A.R. and Morris, P.J. and Powrie, F. and Wood, K.J.
DOI: 10.4049/jimmunol.166.6.3789
2001Fas ligand-transfected myoblasts and islet cell transplantation.
Turvey SE and Gonzalez-Nicolini V and Kingsley CI and Larregina AT and Morris PJ and Castro MG and Lowenstein PR and Wood KJ
DOI: 10.1097/00007890-200005150-00043
PubMed: 10830245
05/2000Islet allograft rejection can be mediated by CD4+, alloantigen experienced, direct pathway T cells of Th1 and Th2 cytokine phenotype1
Transplantation
Barbara, J.A.J. and Turvey, S.E. and Kingsley, C.I. and Spriewald, B.M. and Hara, M. and Witzke, O. and Morris, P.J. and Wood, K.J.
DOI: 10.1097/00007890-200012150-00017
2000Fas ligand-transfected myoblasts and islet cell transplantation
Transplantation
Turvey, S.E. and Gonzalez-Nicolini, V. and Kingsley, C.I. and Larregina, A.T. and Morris, P.J. and Castro, M.G. and Lowenstein, P.R. and Wood, K.J.
2000New insights on the mechanisms of acquired intrathymic tolerance
Current Opinion in Organ Transplantation
Stuart E. Turvey and Jeremy W. Fry and Kathryn J. Wood
DOI: 10.1097/00075200-199903000-00010
03/1999Mechanisms of tolerance induction after intrathymic islet injection: Determination of the fate of alloreactive thymocytes
Transplantation
Turvey, S.E. and Hara, M. and Morris, P.J. and Wood, K.J.
1999Immunobiology of solid organ transplantation
International Surgery
Turvey, S.E. and Wood, K.J.
1999Direct allorecognition: A mechanism in intrathymic tolerance induction
Transplantation Proceedings
DOI: 10.1016/S0041-1345(98)01798-9
1999Islet allografts: Rejection and tolerance induction
Transplantation Proceedings
DOI: 10.1016/S0041-1345(98)01597-8
1999The visualization of T cell responses
Transplantation
Barbara, J.A.J. and Gilot, B.J. and Hara, M. and Van Maurik, A. and Jones, N.D. and Turvey, S.E. and Wood, K.J.
DOI: 10.1097/00007890-199906270-00002
1999Immunobiology of solid organ transplantation.
Turvey SE and Wood KJ
PubMed: 10667806
1999Changes in myoplasmic sodium concentration during exposure to lactate in perfused rat heart
Cardiovascular Research
Turvey, S.E. and Allen, D.G.
DOI: 10.1093/cvrese/28.7.987
1994Intracellular Calcium and Myocardial Function During Ischemia
Interactive Phenomena in the Cardiac System
David G. Allen and Simeon P. Cairns and Stuart E. Turvey and John A. Lee
DOI: 10.1007/978-1-4615-2946-0_3
1993 - Research
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Harnessing the power of genomics to diagnose, treat and prevent pediatric immune disorders
Primary immunodeficiency diseases (PIDs) are a group of genetic disorders in which parts of the immune system are missing or dysfunctional. PIDs interfere with essential protective immune functions, greatly enhancing susceptibility to infections, autoimmunity, inflammation, and certain malignancies. The study of PIDs has played a critical role in expanding our understanding of the immune system and the development of treatment strategies that have applications far beyond PIDs. Despite our growing understanding of PIDs, many cases remain undiagnosed. My lab uses the power of genomics, including next-generation sequencing (NGS) technology, to discover the cause of novel PIDs, to accelerate diagnosis, to define target treatments, and to improve outcomes for children and their families.Early-life origins of asthma and allergic disease
Asthma is a chronic inflammatory disease of the airways that typically begins in childhood. In Canada, more than 8% of people (~2.4 million in 2014) have been diagnosed with asthma. The underlying cause of asthma is a complex product of genetic and environmental factors; however research suggests that early life exposure to microbes alters immune system priming to increase susceptibility to asthma and allergic diseases. My lab aims to identify key compositional differences in the early-life gut microbiome, and metabolome between children who develop asthma and those who remain healthy, which can ultimately be targeted to predict and prevent asthma.Canadian Healthy Infant Longitudinal Development (CHILD) Study
Over the past 30 years there has been an increasing concern about the effects of environment on health. In particular, since infants spend the majority of their time indoors, there is intense interest in the impact indoor pollution has on the health of our children. Our indoor environment has become a public health priority as growing evidence suggests that unseen environmental contaminants in our living spaces may have important effects on children's health and development.
The Canadian Healthy Infant Longitudinal Development (CHILD) Study is a multicentre, multidisciplinary, longitudinal, population-based birth-cohort study of -approximately 3,500 children enrolled "pre-birth" and followed until adolescence (www.childstudy.ca). The main purpose of this study is to determine what aspects of the environment interact with genetic factors to affect children’s health and development. I am a co-principal investigator for the CHILD study and I lead the Vancouver study site.Honours & AwardsAubrey J. Tingle Professorship in Pediatric Immunology, 2012 - present
Canada Research Chair in Pediatric Precision Health, 2019 - present
Geoffrey L. Hammond Lectureship, 2018
Canadian Society of Allergy and Clinical Immunology, Award for Research in Immunology 2013
Career Investigator Scholar Award, Michael Smith Foundation for Health Research, 2011-19.
Research Group MembersLily Buder, Undergraduate Academic Assistant
Darlene Dai, Biostatistician
Alex Dempsey
Rajdeep Dhillon, Undergraduate Research Assistant
Liam Golding
Courtney Hoskinson, PhD Candidate
Jill Lim, Research Assistant
Massimo Mangino, Research Associate
Cassie McDonald, Genetic Counsellor
Bhavi Pinesh Modi, Research Associate
Trine Moelbaek Jensen, Visting PhD student (MD at Herlev and Gentofte Hospital, Copenhagen)
Charisse Petersen, Research Associate
Kiana Rashidi, Work Learn Student
Phillip Richmond, Staff Scientist, PHSA
Simran Samra, PhD Student
Erika Sifuentes, Research Coordinator
Leandro B R Silva, Research Associate
Mattison Stojcic, Undergraduate Research Assistant, Graduate Student
Valerie Tolsma, Administrative Assistant
Jennifer Vanderlei, Administrative Assistant
Maryam Vaseghi, Doctoral student
Nicholas Viegas, Research Assistant (Tech 1)
Ethel Wai, Research Assistant
David Yao, Research Assistant
Reimagining Patient Care: Q&A with Dr. Stuart Turvey, Precision Health Lead
In 2016, BC Children’s Hospital Research Institute set out to become one of the top pediatric research institutes in North America. To achieve this, BCCHR set out their strategic initiatives to create innovative solutions to some of the biggest health problems. We spoke with Dr. Stuart Turvey to discuss the Precision Health Initiative and its role in the future of medicine.
