Overview

My research interests involve both sepsis and quality assurance in the emergency department.

Sepsis is a term used to describe what happens when the body mounts an inflammatory response to an infection. In fact, this response is what often does more damage to a patient, rather than the infection itself. My research interest with respect to sepsis is to try and determine early on which patient is going to have a minimal response and which patient is going to have a catastrophic response leading to shock.

In addition, I have an interest in how we sedate patients in the emergency room when painful procedures are required. I currently am involved in implementing new, and hopefully better, medications for this and studying their implementation to ensure that they are safe and effective in for use in the emergency room.

Publications

Anaphylaxis across two Canadian pediatric centers: evaluating management disparities.
Lee AY, Enarson P, Clarke AE, La Vieille S, Eisman H, Chan ES, Mill C, Joseph L, Ben-Shoshan M
DOI: 10.2147/jaa.s123053
PubMed: 28115856
2017

Rapid viral diagnosis for acute febrile respiratory illness in children in the Emergency Department.
Doan Q, Enarson P, Kissoon N, Klassen TP, Johnson DW
DOI: 10.1002/14651858.cd006452.pub4
PubMed: 25222468
2014

Commentaries on 'procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections' with a response from the review authors.
Sabhaney V, Enarson P, Irwin AD, Carrol ED
DOI: 10.1002/ebch.1928
PubMed: 23877945
07/2013

Encephalitis.
Weingarten L, Enarson P, Klassen T
DOI: 10.1097/pec.0b013e318280d7f3
PubMed: 23546434
02/2013

Rapid viral diagnosis for acute febrile respiratory illness in children in the Emergency Department.
Doan Q, Enarson P, Kissoon N, Klassen TP, Johnson DW
DOI: 10.1002/14651858.cd006452.pub3
PubMed: 22592711
2012

Dimenhydrinate use for children with vomiting.
Enarson P, Gouin S, Goldman RD
PubMed: 21490354
04/2011

Rapid viral diagnosis for acute febrile respiratory illness in children in the Emergency Department.
Doan Q, Enarson P, Kissoon N, Klassen TP, Johnson DW
DOI: 10.1002/14651858.cd006452.pub2
PubMed: 19821366
2009

Autoantigens of the nuclear pore complex.
Enarson P, Rattner JB, Ou Y, Miyachi K, Horigome T, Fritzler MJ
DOI: 10.1007/s00109-004-0554-z
PubMed: 15175862
07/2004

The nuclear pore complex protein Tpr is a common autoantigen in sera that demonstrate nuclear envelope staining by indirect immunofluorescence.
Ou Y, Enarson P, Rattner JB, Barr SG, Fritzler MJ
DOI: 10.1111/j.1365-2249.2004.02432.x
PubMed: 15086405
05/2004

Nup358 integrates nuclear envelope breakdown with kinetochore assembly.
Salina D, Enarson P, Rattner JB, Burke B
DOI: 10.1083/jcb.200304080
PubMed: 12963708
09/2003

Nuclear envelope defects associated with LMNA mutations cause dilated cardiomyopathy and Emery-Dreifuss muscular dystrophy.
Raharjo WH, Enarson P, Sullivan T, Stewart CL, Burke B
PubMed: 11792810
12/2001

Nuclear envelope dynamics.
Salina D, Bodoor K, Enarson P, Raharjo WH, Burke B
DOI: 10.1139/bcb-79-5-533
PubMed: 11716295
2001

Function and assembly of nuclear pore complex proteins.
Bodoor K, Shaikh S, Enarson P, Chowdhury S, Salina D, Raharjo WH, Burke B
DOI: 10.1139/o99-038
PubMed: 10546895
1999

Amino-terminal sequences that direct nucleoporin nup153 to the inner surface of the nuclear envelope.
Enarson P, Enarson M, Bastos R, Burke B
DOI: 10.1007/s004120050301
PubMed: 9745047
09/1998

Research

Current Projects
My current research involves three projects.

The first is a national anaphylaxis registry (C-CARE). I am the site lead for UBC. The primary objective of the CCARE study (Cross Canada Anaphylaxis Registry) is to assess the rate, triggers and management of anaphylaxis in emergency medical services, emergency departments, and allergy clinics across Canada. It is hoped that through this registry, we will obtain the first reliable estimate of anaphylaxis rates in Canada using prospectively collected data from several sources. The registry will also identify conventional and emerging triggers for anaphylaxis and explore demographic and environmental factors that may be involved in its pathogenesis. By characterizing current diagnostic and treatment practices for anaphylaxis, the C-CARE initiative will identify related gaps and inform the development of more comprehensive and effective management strategies.

The second project is a multi-disciplinary study, led by Dr. Ash Singhal at BC Children’s Hospital, looking at if we can obtain better views of younger patients’ (ages 1-5 years) optic discs with an indirect ophthalmoscope if we distract them with images on an iPad. Indirect ophthalmoscope exams are an important part of any neurologic exam, but also extremely difficult in younger, uncooperative patients. It is hoped that this new technique will make this exam much easier. My role is the study lead for the emergency department arm of the study.

The third project relates to safe implementation of new sedation drugs for the emergency department. We currently are in the process of implementing two new drugs, nitrous oxide and propofol, and I have been working on reviewing the literature to ensure safety and efficacy of these two drugs. Once implemented, we will be working on quality assurance projects to ensure that these drugs are suitable for our emergency department at BC Children’s Hospital.

Honours & Awards

2012 UBC Department of Pediatrics Rookie of the Year Award

2005 Leaders in Medicine Scholarship