Overview

As a neonatologist, I am regularly involved in the medical care of infants needing intensive medical care at birth. Newborns are particularly vulnerable to infections. Infection and prematurity are leading causes of mortality and long-term health problems. My lab focuses on understanding the development of the immune system in humans before and at birth, and how to use this knowledge to prevent diseases in this age group.

We also work on understanding why some human individuals are more susceptible to infections or auto-immune/inflammatory conditions compared to others, in the general population and across development. To do so, we employ a combination of translational research approaches (population-based clinical studies, epidemiology, but lab-based human immunology and molecular biology, but also clinical trials/interventional studies. We also have ongoing collaboration nationally and internationally (US/Europe) to understand risk factors for neonatal infections, genetics of BPD, HIV, vaccine development, microbiome and human immunology traits.

Publications

A Time-Based Analysis of Inflammation in Infants at Risk of Bronchopulmonary Dysplasia
The Journal of Pediatrics
Sandrine Leroy, Elsa Caumette, Chandra Waddington, Audrey Hébert, Rollin Brant, Pascal M. Lavoie
DOI: 10.1016/j.jpeds.2017.09.011
01/2018

Genome-wide association study of bronchopulmonary dysplasia: a potential role for variants near the CRP gene
Scientific Reports
Mari Mahlman, Minna K. Karjalainen, Johanna M. Huusko, Sture Andersson, M. Anneli Kari, Outi K. T. Tammela, Ulla Sankilampi, Liisa Lehtonen, Riitta H. Marttila, Dirk Bassler, Christian F. Poets, Thierry Lacaze-Masmonteil, Claude Danan, Christophe Delacourt, Aarno Palotie, Louis J. Muglia, Pascal M. Lavoie, Alice Hadchouel, Mika Rämet, Mikko Hallman
DOI: 10.1038/s41598-017-08977-w
08/2017

Why haven't the documented benefits of probiotics on preterm babies led to their wider acceptance and use?
Acta Paediatrica
Constantin R. Popescu, Leah T. Stiemsma, Pascal M. Lavoie
DOI: 10.1111/apa.13893
08/2017

The phenotype and function of preterm infant monocytes: implications for susceptibility to infection
Journal of Leukocyte Biology
Emma de Jong, Tobias Strunk, David Burgner, Pascal M. Lavoie, Andrew Currie
DOI: 10.1189/jlb.4ru0317-111r
06/2017

Respiratory syncytial virus-neutralizing serum antibody titers in infants following palivizumab prophylaxis with an abbreviated dosing regimen
PLOS ONE
Jennifer Claydon, Amitava Sur, Allison Callejas, Mihoko Ladd, Eddie Kwan, Richard Taylor, Stuart E. Turvey, Alfonso Solimano, Pascal M. Lavoie, Nico Marr
DOI: 10.1371/journal.pone.0176152
04/2017

Cord blood hematopoietic cells from preterm infants display altered DNA methylation patterns
Clinical Epigenetics
Olivia M. de Goede, Pascal M. Lavoie, Wendy P. Robinson
DOI: 10.1186/s13148-017-0339-1
04/2017

Antifungal Immunological Defenses in Newborns
Frontiers in Immunology
Christina Michalski, Bernard Kan, Pascal M. Lavoie
DOI: 10.3389/fimmu.2017.00281
03/2017

A Potential Role for the NOD1 Variant (rs6958571) in Gram-Positive Blood Stream Infection in ELBW Infants
Neonatology
Venkatesh Sampath and Neil Mulrooney and Aloka L. Patel and Jonathan Cohen and Liyun Zhang and Jeffery Garland and Pascal M. Lavoie and John Dagle and Pippa Simpson
DOI: 10.1159/000477433
2017

Mononuclear Phagocyte System
Fetal and Neonatal Physiology
Pascal M. Lavoie and Ofer Levy
DOI: 10.1016/b978-0-323-35214-7.00125-6
2017

A functional ATG16L1 (T300A) variant is associated with necrotizing enterocolitis in premature infants
Pediatric Research
Venkatesh Sampath, Vineet Bhandari, Jessica Berger, Daniel Merchant, Liyun Zhang, Mihoko Ladd, Heather Menden, Jeffery Garland, Namasivayam Ambalavanan, Neil Mulrooney, Michael Quasney, John Dagle, Pascal M. Lavoie, Pippa Simpson, Mary Dahmer
DOI: 10.1038/pr.2016.260
11/2016

Characterizing the hypomethylated DNA methylation profile of nucleated red blood cells from cord blood
Epigenomics
Olivia M de Goede, Pascal M Lavoie, Wendy P Robinson
DOI: 10.2217/epi-2016-0069
11/2016

An Immunological Perspective on Neonatal Sepsis
Trends in Molecular Medicine
Bernard Kan, Hamid Reza Razzaghian, Pascal M. Lavoie
DOI: 10.1016/j.molmed.2016.02.001
04/2016

Outcomes of Respiratory Syncytial Virus Immunoprophylaxis in Infants Using an Abbreviated Dosing Regimen of Palivizumab
JAMA Pediatrics
Pascal M. Lavoie, Alfonso Solimano, Richard Taylor, Eddie Kwan, Jennifer Claydon, Stuart E. Turvey, Nico Marr
DOI: 10.1001/jamapediatrics.2015.3235
02/2016

Multiple Successful Angioembolizations for Refractory Cardiac Failure in a Preterm with Rapidly Involuting Congenital Hemangioma
American Journal of Perinatology Reports
Amitava Sur, Heran Manraj, Pascal Lavoie, Ken Lim, Douglas Courtemanche, Paul Brooks, Susan Albersheim
DOI: 10.1055/s-0035-1570342
01/2016

Genetics of Bronchopulmonary Dysplasia
Bronchopulmonary Dysplasia
Pascal M. Lavoie
DOI: 10.1007/978-3-319-28486-6_6
2016

Cardiac Autonomic Function at Baseline and under Stress and Its Relationship to Circulatory Markers of Inflammation in Obese Compared to Nonobese Children: A Pilot Study
Hormone Research in Paediatrics
Brenden E. Hursh, Mir Sohail Fazeli, Sarah Wang, Elizabeth A. Marchant, Paula Woo, Rajavel Elango, Pascal M. Lavoie, Jean-Pierre Chanoine, Jean-Paul Collet
DOI: 10.1159/000445685
2016

Editor’s Focus
Pediatric Research
Elizabeth A. Marchant, Bernard Kan, Ashish A. Sharma, Alice van Zanten, Tobias R. Kollmann, Rollin Brant, Pascal M. Lavoie
DOI: 10.1038/pr.2015.171
10/2015

A Randomized Controlled Trial of the Use of Oral Glucose with or without Gentle Facilitated Tucking of Infants during Neonatal Echocardiography
PLOS ONE
Pascal M. Lavoie, Amelie Stritzke, Joseph Ting, Mohammad Jabr, Amish Jain, Eddie Kwan, Ela Chakkarapani, Paul Brooks, Rollin Brant, Patrick J. McNamara, Liisa Holsti
DOI: 10.1371/journal.pone.0141015
10/2015

Nucleated red blood cells impact DNA methylation and expression analyses of cord blood hematopoietic cells
Clinical Epigenetics
Olivia M. de Goede, Hamid R. Razzaghian, E. Magda Price, Meaghan J. Jones, Michael S. Kobor, Wendy P. Robinson, Pascal M. Lavoie
DOI: 10.1186/s13148-015-0129-6
09/2015

Attenuated innate immune defenses in very premature neonates during the neonatal period
Pediatric Research
Elizabeth A. Marchant, Bernard Kan, Ashish A. Sharma, Alice van Zanten, Tobias R. Kollmann, Rollin Brant, Pascal M. Lavoie
DOI: 10.1038/pr.2015.132
07/2015

The Crohn’s disease-associated polymorphism in ATG16L1 (rs2241880) reduces SHIP gene expression and activity in human subjects
Genes & Immunity
E N Ngoh, H K Brugger, M Monajemi, S C Menzies, A F Hirschfeld, K L Del Bel, K Jacobson, P M Lavoie, S E Turvey, L M Sly
DOI: 10.1038/gene.2015.30
07/2015

Malaria in immigrant and traveler children: Clinical presentation and risk factors for complications
Journal of Pediatric Infectious Diseases
Pascal Lavoie, Monique Robert, Marc Lebel, Dorothy Moore, Selim Rashed, Ana Carceller
DOI: 10.1055/s-0035-1557058
07/2015

Oral glucose during targeted neonatal echocardiography: is it useful?: Table 1
Archives of Disease in Childhood - Fetal and Neonatal Edition
Pascal M Lavoie, Amelie Stritzke, Joseph Ting, Mohammad Jabr, Amish Jain, Eddie Kwan, Ela Chakkarapani, Paul Brooks, Rollin Brant, Patrick J McNamara, Liisa Holsti
DOI: 10.1136/archdischild-2015-308191
06/2015

Cerebral Palsy and Polymorphism of the Chemokine in Very Preterm Children
Neonatology
Hanna Kallankari, Johanna M. Huusko, Tuula Kaukola, Marja Ojaniemi, Mari Mahlman, Riitta Marttila, Stephen F. Kingsmore, Leena Haataja, Pascal M. Lavoie, Anne Synnes, Mikko Hallman
DOI: 10.1159/000430765
2015

Genes Encoding Vascular Endothelial Growth Factor A (VEGF-A) and VEGF Receptor 2 (VEGFR-2) and Risk for Bronchopulmonary Dysplasia
Neonatology
Mari Mahlman, Johanna M. Huusko, Minna K. Karjalainen, Tuula Kaukola, Riitta Marttila, Marja Ojaniemi, Ritva Haataja, Pascal M. Lavoie, Mika Rämet, Mikko Hallman, on behalf of the Gen-BPD Study Group
DOI: 10.1159/000381279
2015

Impaired NLRP3 inflammasome activity during fetal development regulates IL-1ß production in human monocytesInnate immunity
European Journal of Immunology
Ashish A. Sharma, Roger Jen, Bernard Kan, Abhinav Sharma, Elizabeth Marchant, Anthony Tang, Izabelle Gadawski, Christof Senger, Amanda Skoll, Stuart E. Turvey, Laura M. Sly, Hélène C.F. Côté, Pascal M. Lavoie
DOI: 10.1002/eji.201444707
11/2014

A study of genes encoding cytokines (IL6, IL10, TNF), cytokine receptors (IL6R, IL6ST), and glucocorticoid receptor (NR3C1) and susceptibility to bronchopulmonary dysplasia
BMC Medical Genetics
Johanna M Huusko, Minna K Karjalainen, Mari Mahlman, Ritva Haataja, M Anneli Kari, Sture Andersson, Gergely Toldi, Outi Tammela, Mika Rämet, Pascal M Lavoie, Mikko Hallman
DOI: 10.1186/s12881-014-0120-7
11/2014

Catecholamine-resistant hypotension and myocardial performance following patent ductus arteriosus ligation
Journal of Perinatology
S Noori, PDA Ligation/Hypotension Trial Investigators, P McNamara, A Jain, P M Lavoie, A Wickremasinghe, T A Merritt, T Solomon, K Sekar, J T Attridge, J R Swanson, M Gillam-Krakauer, J Reese, B B Poindexter, M Brook, R J Auchus, R I Clyman
DOI: 10.1038/jp.2014.151
08/2014

Hypotension following Patent Ductus Arteriosus Ligation: The Role of Adrenal Hormones
The Journal of Pediatrics
Ronald I. Clyman, Andrea Wickremasinghe, T. Allen Merritt, Tabitha Solomon, Patrick McNamara, Amish Jain, Jaideep Singh, Alison Chu, Shahab Noori, Krishnamurthy Sekar, Pascal M. Lavoie, Joshua T. Attridge, Jonathan R. Swanson, Maria Gillam-Krakauer, Jeff Reese, Sara DeMauro, Brenda Poindexter, Sue Aucott, Monique Satpute, Erika Fernandez, Richard J. Auchus
DOI: 10.1016/j.jpeds.2014.01.058
06/2014

Assessment of Genetic Associations between Common Single Nucleotide Polymorphisms in RIG-I-Like Receptor and IL-4 Signaling Genes and Severe Respiratory Syncytial Virus Infection in Children: A Candidate Gene Case-Control Study
PLoS ONE
Nico Marr, Aaron F. Hirschfeld, Angie Lam, Shirley Wang, Pascal M. Lavoie, Stuart E. Turvey
DOI: 10.1371/journal.pone.0100269
06/2014

Omega-3 Long-Chain Polyunsaturated Fatty Acids for Extremely Preterm Infants: A Systematic Review
PEDIATRICS
P. Zhang, P. M. Lavoie, T. Lacaze-Masmonteil, M. Rhainds, I. Marc
DOI: 10.1542/peds.2014-0459
06/2014

Preferential Cephalic Redistribution of Left Ventricular Cardiac Output during Therapeutic Hypothermia for Perinatal Hypoxic-Ischemic Encephalopathy
The Journal of Pediatrics
Ori Hochwald, Mohammad Jabr, Horacio Osiovich, Steven P. Miller, Patrick J. McNamara, Pascal M. Lavoie
DOI: 10.1016/j.jpeds.2014.01.028
05/2014

Polymorphisms of the gene encoding Kit ligand are associated with bronchopulmonary dysplasiaKit Ligand Associates With Bronchopulmonary Dysplasia
Pediatric Pulmonology
Johanna M. Huusko, Mari Mahlman, Minna K. Karjalainen, Tuula Kaukola, Ritva Haataja, Riitta Marttila, Gergely Toldi, Miklós Szabó, Stephen F. Kingsmore, Mika Rämet, Pascal M. Lavoie, Mikko Hallman, on behalf of Gen-BPD Study Group
DOI: 10.1002/ppul.23018
03/2014

Surgical site infections in infants admitted to the neonatal intensive care unit
Journal of Pediatric Surgery
Ilan Segal, Christine Kang, Susan G. Albersheim, Erik D. Skarsgard, Pascal M. Lavoie
DOI: 10.1016/j.jpedsurg.2013.08.001
03/2014

Attenuation of Respiratory Syncytial Virus-Induced and RIG-I-Dependent Type I IFN Responses in Human Neonates and Very Young Children
The Journal of Immunology
N. Marr, T.-I. Wang, S. H. Y. Kam, Y. S. Hu, A. A. Sharma, A. Lam, J. Markowski, A. Solimano, P. M. Lavoie, S. E. Turvey
DOI: 10.4049/jimmunol.1302007
01/2014

Hierarchical Maturation of Innate Immune Defences in Very Preterm Neonates
Neonatology
Ashish Arunkumar Sharma, Roger Jen, Rollin Brant, Mihoko Ladd, Qing Huang, Amanda Skoll, Christof Senger, Stuart E. Turvey, Nico Marr, Pascal M. Lavoie
DOI: 10.1159/000358550
2014

Neonatal Pain-Related Stress and NFKBIA Genotype Are Associated with Altered Cortisol Levels in Preterm Boys at School Age
PLoS ONE
Ruth E. Grunau, Ivan L. Cepeda, Cecil M. Y. Chau, Susanne Brummelte, Joanne Weinberg, Pascal M. Lavoie, Mihoko Ladd, Aaron F. Hirschfeld, Evan Russell, Gideon Koren, Stan Van Uum, Rollin Brant, Stuart E. Turvey
DOI: 10.1371/journal.pone.0073926
09/2013

Response to Comment on "Helios+ and Helios- Cells Coexist within the Natural FOXP3+ T Regulatory Cell Subset in Humans"
The Journal of Immunology
K. G. MacDonald, J. M. Han, M. E. Himmel, Q. Huang, B. Kan, A. I. M. Campbell, P. M. Lavoie, M. K. Levings
DOI: 10.4049/jimmunol.1390019
04/2013

Functional Genetic Variation in NFKBIA and Susceptibility to Childhood Asthma, Bronchiolitis, and Bronchopulmonary Dysplasia
The Journal of Immunology
S. Ali, A. F. Hirschfeld, M. L. Mayer, E. S. Fortuno, N. Corbett, M. Kaplan, S. Wang, J. Schneiderman, C. D. Fjell, J. Yan, L. Akhabir, F. Aminuddin, N. Marr, T. Lacaze-Masmonteil, R. G. Hegele, A. Becker, M. Chan-Yeung, R. E. W. Hancock, T. R. Kollmann, D. Daley, A. J. Sandford, P. M. Lavoie, S. E. Turvey
DOI: 10.4049/jimmunol.1201015
03/2013

Neonatal Sepsis due to Coagulase-Negative Staphylococci
Clinical and Developmental Immunology
Elizabeth A. Marchant, Guilaine K. Boyce, Manish Sadarangani, Pascal M. Lavoie
DOI: 10.1155/2013/586076
2013

The developing human preterm neonatal immune system: A case for more research in this area
Clinical Immunology
Ashish Arunkumar Sharma, Roger Jen, Alison Butler, Pascal M. Lavoie
DOI: 10.1016/j.clim.2012.08.006
10/2012

Inflammasome-Mediated IL-1ß Production in Humans with Cystic Fibrosis
PLoS ONE
Anthony Tang, Ashish Sharma, Roger Jen, Aaron F. Hirschfeld, Mark A. Chilvers, Pascal M. Lavoie, Stuart E. Turvey
DOI: 10.1371/journal.pone.0037689
05/2012

Influence of Common Non-Synonymous Toll-like Receptor 4 Polymorphisms on Bronchopulmonary Dysplasia and Prematurity in Human Infants
PLoS ONE
Pascal M. Lavoie, Mihoko Ladd, Aaron F. Hirschfeld, Johanna Huusko, Mari Mahlman, David P. Speert, Mikko Hallman, Thierry Lacaze-Masmonteil, Stuart E. Turvey
DOI: 10.1371/journal.pone.0031351
02/2012

Ex vivo purification and characterization of human invariant natural killer T cells
Journal of Immunological Methods
Ashish Arunkumar Sharma, Leon Chew, Mihoko Ladd, Roger Jen, Pascal M. Lavoie
DOI: 10.1016/j.jim.2011.08.002
10/2011

Early inflammation in the absence of overt infection in preterm neonates exposed to intensive care
Cytokine
Brent A. Chang, Qing Huang, Joanne Quan, Vann Chau, Mihoko Ladd, Eddie Kwan, Deborah E. McFadden, Thierry Lacaze-Masmonteil, Steven P. Miller, Pascal M. Lavoie
DOI: 10.1016/j.cyto.2011.08.028
2011

Ontogeny of Toll-Like Receptor Mediated Cytokine Responses of Human Blood Mononuclear Cells
PLoS ONE
Nathan P. Corbett, Darren Blimkie, Kevin C. Ho, Bing Cai, Darren P. Sutherland, Arlene Kallos, Juliet Crabtree, Annie Rein-Weston, Pascal M. Lavoie, Stuart E. Turvey, Natalie R. Hawkins, Steven G. Self, Christopher B. Wilson, Adeline M. Hajjar, Edgardo S. Fortuno, Tobias R. Kollmann
DOI: 10.1371/journal.pone.0015041
11/2010

Inflammatory Response in Preterm Infants Is Induced Early in Life by Oxygen and Modulated by Total Parenteral Nutrition
Pediatric Research
Pascal M Lavoie, Jean-Claude Lavoie, Carla Watson, Thérèse Rouleau, Brent A Chang, Philippe Chessex
DOI: 10.1203/pdr.0b013e3181eb2f18
09/2010

Natural killer T cells constitutively expressing the interleukin-2 receptor a chain early in life are primed to respond to lower antigenic stimulationCD25 expression primes neonatal iNKT cells
Immunology
Mihoko Ladd, Ashish Sharma, Qing Huang, Adele Y. Wang, Lixin Xu, Indira Genowati, Megan K. Levings, Pascal M. Lavoie
DOI: 10.1111/j.1365-2567.2010.03304.x
09/2010

Genetics of bronchopulmonary dysplasia in the age of genomics
Current Opinion in Pediatrics
Pascal M Lavoie, Marie-Pierre Dubé
DOI: 10.1097/mop.0b013e328336eb85
04/2010

Incidence of septicemia immediately after elective gastrointestinal contrast procedures in infants: a cohort study
Journal of Pediatric Surgery
Ziad Abu-Sharar, Ashley Robinson, Pascal M. Lavoie
DOI: 10.1016/j.jpedsurg.2009.07.023
03/2010

Constitutive Expression of CD25 on the Surface of Neonatal (invariant) Natural Killer T Cells Primes Them to Proliferate with Lower Antigenic Stimulation
Clinical Immunology
Ashish Sharma, Mihoko Whalen, Qing Huang, Adele Wang, Lixin Xu, Indira Genowati, Meghan Levings, Pascal Lavoie
DOI: 10.1016/j.clim.2010.03.151
01/2010

Do neonatologists limit parental decision-making authority? A Canadian perspective
Early Human Development
Susan G. Albersheim, Pascal M. Lavoie, Yaron D. Keidar
DOI: 10.1016/j.earlhumdev.2010.09.007
2010

Profound Lack of Interleukin (IL)–12/IL-23p40 in Neonates Born Early in Gestation Is Associated with an Increased Risk of Sepsis
The Journal of Infectious Diseases
Pascal M. Lavoie, Qing Huang, Elyse Jolette, Mihoko Whalen, Anne Monique Nuyt, Francois Audibert, David P. Speert, Thierry Lacaze-Masmonteil, Hugo Soudeyns, Tobias R. Kollmann
DOI: 10.1086/657143
2010

Neonatal Innate TLR-Mediated Responses Are Distinct from Those of Adults
The Journal of Immunology
T. R. Kollmann, J. Crabtree, A. Rein-Weston, D. Blimkie, F. Thommai, X. Y. Wang, P. M. Lavoie, J. Furlong, E. S. Fortuno, A. M. Hajjar, N. R. Hawkins, S. G. Self, C. B. Wilson
DOI: 10.4049/jimmunol.0901481
11/2009

Earlier initiation of enteral nutrition is associated with lower risk of late-onset bacteremia only in most mature very low birth weight infants
Journal of Perinatology
P M Lavoie
DOI: 10.1038/jp.2009.8
02/2009

Heritability of Bronchopulmonary Dysplasia, Defined According to the Consensus Statement of the National Institutes of Health
PEDIATRICS
P. M. Lavoie, C. Pham, K. L. Jang
DOI: 10.1542/peds.2007-2313
09/2008

Gastrointestinal Presentation of Relative Adrenal Insufficiency in a Sick Preterm Neonate
American Journal of Perinatology
Pascal Lavoie, Gustavo Pelligra, Brian Lupton, Horacio Osiovich
DOI: 10.1055/s-2007-986694
09/2007

Attitudes of Canadian Neonatologists in Delivery Room Resuscitation of Newborns at Threshold of Viability
Journal of Obstetrics and Gynaecology Canada
Pascal M. Lavoie, Yaron Keidar, Susan Albersheim
DOI: 10.1016/s1701-2163(16)32599-3
09/2007

Delayed expansion of a restricted T cell repertoire by low-density TCR ligands
International Immunology
Pascal M. Lavoie, Alain R. Dumont, Helen McGrath, Anne-Elen Kernaleguen, Rafick-P. Sékaly
DOI: 10.1093/intimm/dxh273
06/2005

Lead poisoning from "lead-free" paint
Canadian Medical Association Journal
P. M. Lavoie
DOI: 10.1503/cmaj.1031524
03/2004

Quantitative Relationship Between MHC Class II-Superantigen Complexes and the Balance of T Cell Activation Versus Death
The Journal of Immunology
P. M. Lavoie, H. McGrath, N. H. Shoukry, P.-A. Cazenave, R.-P. Sekaly, J. Thibodeau
DOI: 10.4049/jimmunol.166.12.7229
06/2001

Superantigen presenting capacity of human astrocytes
Journal of Neuroimmunology
Mina Hassan-Zahraee, Uma Ladiwala, Pascal M Lavoie, Ellie McCrea, Rafick P Sekaly, Trevor Owens, Jack P Antel
DOI: 10.1016/s0165-5728(99)00174-5
01/2000

Understanding the mechanism of action of bacterial superantigens from a decade of research
Immunological Reviews
Pascal M. Lavoie, Jacques Thibodeau, Francois Erard, Rafick-Pierre Sekaly
DOI: 10.1111/j.1600-065x.1999.tb01297.x
04/1999

Role of the T Cell Receptor a Chain in Stabilizing TCR-Superantigen-MHC Class II Complexes
Immunity
Peter S Andersen, Pascal M Lavoie, Rafick-Pierre Sékaly, Hywyn Churchill, David M Kranz, Patrick M Schlievert, Klaus Karjalainen, Roy A Mariuzza
DOI: 10.1016/s1074-7613(00)80047-3
04/1999

Conserved structural features between HLA-DOß and -DRß
Molecular Immunology
DOI: 10.1016/s0161-5890(98)00061-3
09/1998

A Mutational Analysis of the Binding of Staphylococcal Enterotoxins B and C3 to the T Cell Receptor ß Chain and Major Histocompatibility Complex Class II
The Journal of Experimental Medicine
Lukas Leder, Andrea Llera, Pascal M. Lavoie, Marina I. Lebedeva, Hongmin Li, Rafick-Pierre Sékaly, Gregory A. Bohach, Pamala J. Gahr, Patrick M. Schlievert, Klaus Karjalainen, Roy A. Mariuzza
DOI: 10.1084/jem.187.6.823
03/1998

L'infection par le VIH : importance des facteurs de l'hôte.
médecine/sciences
P Champagne, PM Lavoie, RP Sékaly, A Yachou
DOI: 10.4267/10608/1001
1998

Selective binding of bacterial toxins to major histocompatibility complex class II-expressing cells is controlled by invariant chain and HLA-DM
Proceedings of the National Academy of Sciences
P. M. Lavoie, J. Thibodeau, I. Cloutier, R. Busch, R.-P. Sekaly
DOI: 10.1073/pnas.94.13.6892
06/1997

MHC Class II-Dependent Peptide Antigen Versus Superantigen Presentation to T Cells
Human Immunology
Naglaa H Shoukry, Pascal M Lavoie, Jacques Thibodeau, Sushila D’Souza, Rafick P Sekaly
DOI: 10.1016/s0198-8859(97)00074-8
05/1997

“Bazinc” instinct: how SEA attracts MHC class II molecules
Research in Immunology
J. Thibodeau, P.M. Lavoie, P.-A. Cazenave
DOI: 10.1016/s0923-2494(97)80864-4
05/1997

Molecular characterization and role in T cell activation of staphylococcal enterotoxin A binding to the HLA-DR alpha-chain.
The Journal of Immunology
1997

Subsets of HLA-DR1 molecules defined by SEB and TSST-1 binding
Science
J Thibodeau, I Cloutier, P. Lavoie, N Labrecque, W Mourad, T Jardetzky, R. Sekaly
DOI: 10.1126/science.7997881
1994

Research

Anti-inflamatory treatment for bronchopulmonary dysplasia
We are one of the leading centres of the CIHR-funded MOBYDICK Canadian multi-centre randomized clinical trial to determine whether maternal omega-3 supplementation effectively reduces bronchopulmonary dysplasia in very preterm infants.

Heritability of bronchopulmonary dysplasia
Bronchopulmonary dysplasia (BPD) is a form of chronic inflammatory-mediated lung disease affecting thousands of infants born prematurely each year in Canada. BPD is a serious disease which often results in significant morbidity and mortality. Clinicians lack a cure for BPD and current treatments can have serious side-effects. Evidence suggests that susceptibility to this condition is in part genetically inherited. In this study, we collaborate with other neonatal centres internationally to examine the role of common gene polymorphisms in clinically well-characterized cohorts of preterm infants, in order to understand how genetic factors interact in the regulation of inflammation and how they predispose infants to BPD and neonatal conditions more generally.

Innate and adaptive immune defences in human neonates across development
We aim to define characteristics of innate and adaptive immune system in newborns as well as preterm infants that sometimes fail to protect them against infection and inflammatory-mediated neonatal diseases. We study adaptive T cell function in the context of vaccine responses. We develop small scaled immunoassays to characterize the immunological phenotype of these infants from 24 weeks to the term of gestation. We employ molecular and human cell-based immunology approaches (advanced flow cytometry). Our current focus is on the Toll-like receptor/inflammasome innate immune pathways as well as neonatal T cell differentiation.

Grants

CIHR Operating Grant – Project: "Maternal Omega-3 supplementation to reduce Bronchopulmonary Dysplasia in very Preterm Infants : A Randomized Controlled Trial (MOBYDIck Trial)" (2014-2019)

CIHR Operating Grant – Project: "Understanding the immunological basis for early-life infections in preterm infants" (2012-2017)

Honours & Awards

CFRI Clinician-Scientist Award – 2008-2013

Michael Smith Foundation for Health Research – Career Investigator Award – 2011-2019

Research Group Members

Elizabeth Marchant
Christina Michalski, Doctoral Student
Zohreh Sharafian, Research Assistant
Constantin Radu Popescu, Doctoral Student
Maye Cheng, Co-op Student