Overview

My training is in statistics, mathematics and computer science but I have spent the last 20 years of my career working in collaborative multi-disciplinary research in the health sciences. As a result, my research activity is divided between the development and dissemination of statistical methods applicable to the study of human health and collaborative research in clinical research, with an emphasis on randomized clinical trials.

In the area of statistics, my interest is in methods for translating the often abstract outputs of statistical measurements and analysis into forms that are more intuitively accessible for researchers and decision-makers.

My areas of collaborative research tend to follow the interests of my colleagues doing applied health research. In the last several years I have been involved in a number of high-profile clinical trials looking at invasive monitoring in adult intensive care, the use of corticosteroids in pediatric emergency medicine, and the cardiological application of chelation therapy.

Publications

Response to “Data limitations may affect conclusions in study of vaginal delivery at midpelvic station”
Canadian Medical Association Journal
Giulia M. Muraca and Amanda Skoll and Sarka Lisonkova and Yasser Sabr and Rollin Brant and Geoffrey W. Cundiff and K.S. Joseph
DOI: 10.1503/cmaj.733350
10/2017

The authors reply to “The end of forceps deliveries?” and “Beware selection bias”
Canadian Medical Association Journal
Giulia M. Muraca and Sarka Lisonkova and K.S. Joseph and Amanda Skoll and Geoffrey W. Cundiff and Rollin Brant and Yasser Sabr
DOI: 10.1503/cmaj.733285
08/2017

A Predictive Model for Cesarean Among Low-Risk Nulliparous Women in Spontaneous Labor at Hospital Admission
Birth
DOI: 10.1111/birt.12257
2016

A likelihood-based approach for multivariate one-sided tests with missing data
Journal of Applied Statistics
DOI: 10.1080/02664763.2016.1238054
2016

Temporal and Regional Variations in Operative Vaginal Delivery in Canada by Pelvic Station, 2004-2012
Journal of Obstetrics and Gynaecology Canada
DOI: 10.1016/j.jogc.2016.04.007
2016

Prevalence of alcohol and drug use in injured British Columbia drivers
BMJ Open
DOI: 10.1136/bmjopen-2015-009278
2016

Sequential design for binary dose-response experiments
Journal of Statistical Planning and Inference
DOI: 10.1016/j.jspi.2016.04.005
2016

Prenatal supplementation with Corn Soya Blend Plus reduces the risk of maternal anemia in late gestation and lowers the rate of preterm birth but does not significantly improve maternal weight gain and birth anthropometric measurements in rural Cambodian women: A randomized trial
American Journal of Clinical Nutrition
DOI: 10.3945/ajcn.114.104034
2016

Validating abortion procedure coding in Canadian administrative databases
BMC Health Services Research
DOI: 10.1186/s12913-016-1485-4
2016

Early postnatal docosahexaenoic acid levels and improved preterm brain development
Pediatric Research
DOI: 10.1038/pr.2016.11
2016

Smaller cerebellar growth and poorer neurodevelopmental outcomes in very preterm infants exposed to neonatal morphine
Journal of Pediatrics
DOI: 10.1016/j.jpeds.2015.12.024
2016

Attenuated innate immune defenses in very premature neonates during the neonatal period
Pediatric Research
DOI: 10.1038/pr.2015.132
2015

Maternal thoughts of harm in response to infant crying: an experimental analysis
Archives of Women's Mental Health
DOI: 10.1007/s00737-014-0471-2
2015

Maternal and Perinatal Outcomes of Pregnancies Delivered at 23 Weeks' Gestation
Journal of Obstetrics and Gynaecology Canada
DOI: 10.1016/S1701-2163(15)30307-8
2015

Magnesium sulphate for eclampsia and fetal neuroprotection: A comparative analysis of protocols across Canadian tertiary perinatal centres
Journal of Obstetrics and Gynaecology Canada
DOI: 10.1016/S1701-2163(16)30047-0
2015

Burkholderia species infections in patients with cystic fibrosis in British Columbia, Canada: 30 years' experience
Annals of the American Thoracic Society
DOI: 10.1513/AnnalsATS.201408-395OC
2015

A randomized controlled trial of the use of oral glucose with or without gentle facilitated tucking of infants during neonatal echocardiography
PLoS ONE
DOI: 10.1371/journal.pone.0141015
2015

Education about crying in normal infants is associated with a reduction in pediatric emergency room visits for crying complaints
Journal of Developmental and Behavioral Pediatrics
DOI: 10.1097/DBP.0000000000000156
2015

A randomized controlled trial of an intervention for infants' behavioral sleep problems
BMC Pediatrics
DOI: 10.1186/s12887-015-0492-7
2015

Oral glucose during targeted neonatal echocardiography: Is it useful?
Archives of Disease in Childhood: Fetal and Neonatal Edition
DOI: 10.1136/archdischild-2015-308191
2015

What matters most for patients, parents, and clinicians in the course of juvenile idiopathic arthritis? A qualitative study
Journal of Rheumatology
DOI: 10.3899/jrheum.131536
2014

Effect of Magnesium Sulphate on Fetal Heart Rate Parameters: A Systematic Review
Journal of Obstetrics and Gynaecology Canada
DOI: 10.1016/S1701-2163(15)30382-0
2014

The effect of massage therapy on autonomic activity in critically ill children
Evidence-based Complementary and Alternative Medicine
DOI: 10.1155/2014/656750
2014

What Proportion of Canadian Women Will Accept an Intrauterine Contraceptive at the Time of Second Trimester Abortion? Baseline Data From a Randomized Controlled Trial
Journal of Obstetrics and Gynaecology Canada
DOI: 10.1016/S1701-2163(15)30683-6
2014

Hierarchical maturation of innate immune defences in very preterm neonates
Neonatology
DOI: 10.1159/000358550
2014

Maternal frustration, emotional and behavioural responses to prolonged infant crying
Infant Behavior and Development
DOI: 10.1016/j.infbeh.2014.08.012
2014

Invasive procedures in preterm children: Brain and cognitive development at school age
Pediatrics
DOI: 10.1542/peds.2013-1863
2014

Abnormal brain maturation in preterm neonates associated with adverse developmental outcomes
Neurology
DOI: 10.1212/01.wnl.0000437298.43688.b9
2013

Score for neonatal acute physiology-II and neonatal pain predict Corticospinal tract development in premature newborns
Pediatric Neurology
DOI: 10.1016/j.pediatrneurol.2012.10.016
2013

Anthropometric measures and the risk of endometrial cancer, overall and by tumor microsatellite status and histological subtype
American Journal of Epidemiology
DOI: 10.1093/aje/kws434
2013

Glucocorticoid-related changes in body mass index among children and adolescents with rheumatic diseases
Arthritis Care and Research
DOI: 10.1002/acr.21785
2013

Association between sex hormones, glucose homeostasis, adipokines, and inflammatory markers and mammographic density among postmenopausal women
Breast Cancer Research and Treatment
DOI: 10.1007/s10549-013-2534-x
2013

Neonatal Pain-Related Stress and NFKBIA Genotype Are Associated with Altered Cortisol Levels in Preterm Boys at School Age
PLoS ONE
DOI: 10.1371/journal.pone.0073926
2013

Slower postnatal growth is associated with delayed cerebral cortical maturation in preterm newborns
Science Translational Medicine
DOI: 10.1126/scitranslmed.3004666
2013

Longitudinal changes in IGF-I and IGFBP-3, and mammographic density among postmenopausal women
Cancer Epidemiology Biomarkers and Prevention
DOI: 10.1158/1055-9965.EPI-13-0401
2013

Brain injury and development in newborns with critical congenital heart disease
Neurology
DOI: 10.1212/WNL.0b013e31829bfdcf
2013

Evolution of pattern of injury and quantitative MRI on days 1 and 3 in term newborns with hypoxic-ischemic encephalopathy
Pediatric Research
DOI: 10.1038/pr.2013.69
2013

Effects of Familiarity and Feeding on Newborn Speech-Voice Recognition
Infancy
DOI: 10.1111/j.1532-7078.2012.00140.x
2013

Statistical methods for the meta-analysis of diagnostic tests must take into account the use of surrogate standards
Journal of Clinical Epidemiology
DOI: 10.1016/j.jclinepi.2012.12.008
2013

Prenatal and postnatal inflammation in relation to cortisol levels in preterm infants at 18 months corrected age
Journal of Perinatology
DOI: 10.1038/jp.2013.24
2013

Remotely controlled mandibular protrusion during sleep predicts therapeutic success with oral appliances in patients with obstructive sleep apnea
Sleep
DOI: 10.5665/sleep.3048
2013

Hormonal and reproductive risk factors for sporadic microsatellite stable and unstable endometrial tumors
Cancer Epidemiology Biomarkers and Prevention
DOI: 10.1158/1055-9965.EPI-13-0105
2013

Using international classification of diseases, 10th edition, codes to estimate abusive head trauma in children
American Journal of Preventive Medicine
DOI: 10.1016/j.amepre.2012.04.028
2012

Single course of antenatal steroids did not alter cortisol in preterm infants up to 18 months
Acta Paediatrica, International Journal of Paediatrics
DOI: 10.1111/j.1651-2227.2012.02629.x
2012

Physical activity implementation in schools: A 4-year follow-up
American Journal of Preventive Medicine
DOI: 10.1016/j.amepre.2012.06.010
2012

Postnatal infection is associated with widespread abnormalities of brain development in premature newborns
Pediatric Research
DOI: 10.1038/pr.2011.40
2012

Comparing the effectiveness of copper intrauterine devices available in Canada. Is FlexiT non-inferior to NovaT when inserted immediately after first-trimester abortion? Study protocol for a randomized controlled trial
Trials
DOI: 10.1186/1745-6215-13-147
2012

Identification by families of pediatric adverse events and near misses overlooked by health care providers
CMAJ
DOI: 10.1503/cmaj.110393
2012

Vaginal progesterone to prevent preterm birth in multiple pregnancy: A randomized controlled trial
Journal of Perinatal Medicine
DOI: 10.1515/jpm-2012-0057
2012

Procedural pain and brain development in premature newborns
Annals of Neurology
DOI: 10.1002/ana.22267
2012

Family physicians who provide intrapartum care and those who do not: Very different ways of viewing childbirth
Canadian Family Physician
2011

Mucoid and nonmucoid Burkholderia cepacia complex bacteria in cystic fibrosis infections
American Journal of Respiratory and Critical Care Medicine
DOI: 10.1164/rccm.201002-0203OC
2011

Does breastfeeding reduce acute procedural pain in preterm infants in the neonatal intensive care unit? A randomized clinical trial
Pain
DOI: 10.1016/j.pain.2011.07.022
2011

Adiposity changes after a 1-year aerobic exercise intervention among postmenopausal women: A randomized controlled trial
International Journal of Obesity
DOI: 10.1038/ijo.2010.147
2011

Birth Technology and Maternal Roles in Birth: Knowledge and Attitudes of Canadian Women Approaching Childbirth for the First Time
Journal of Obstetrics and Gynaecology Canada
DOI: 10.1016/S1701-2163(16)34908-8
2011

The Centre for Healthy Weights-Shapedown BC: A family-centered, multidisciplinary program that reduces weight gain in obese children over the short-term
International Journal of Environmental Research and Public Health
DOI: 10.3390/ijerph8124662
2011

Changes in insulin resistance indicators, IGFs, and adipokines in a year-long trial of aerobic exercise in postmenopausal women
Endocrine-Related Cancer
DOI: 10.1530/ERC-10-0303
2011

The Canadian Perinatal Network: A National Network Focused on Threatened Preterm Birth at 22 to 28 Weeks' Gestation
Journal of Obstetrics and Gynaecology Canada
DOI: 10.1016/S1701-2163(16)34795-8
2011

Attitudes of the new generation of canadian obstetricians: How do they differ from their predecessors?
Birth
DOI: 10.1111/j.1523-536X.2010.00462.x
2011

Infant distress at five weeks of age and caregiver frustration
Journal of Pediatrics
DOI: 10.1016/j.jpeds.2011.02.010
2011

Mediators and moderators of the effects of a year-long exercise intervention on endogenous sex hormones in postmenopausal women
Cancer Causes and Control
DOI: 10.1007/s10552-011-9809-5
2011

Immediate vs. delayed insertion of intrauterine contraception after second trimester abortion: Study protocol for a randomized controlled trial
Trials
DOI: 10.1186/1745-6215-12-149
2011

Associations of overall and abdominal adiposity with area and volumetric mammographic measures among postmenopausal women
International Journal of Cancer
DOI: 10.1002/ijc.25676
2011

Normal distribution of palpebral fissure lengths in Canadian school age children
Journal of Population Therapeutics and Clinical Pharmacology
2010

Alberta physical activity and breast cancer prevention trial: Sex hormone changes in a year-long exercise intervention among postmenopausal women
Journal of Clinical Oncology
DOI: 10.1200/JCO.2009.24.9557
2010

Mammographic density change with 1 Year of aerobic exercise among postmenopausal women: A randomized controlled trial
Cancer Epidemiology Biomarkers and Prevention
DOI: 10.1158/1055-9965.EPI-09-0801
2010

The effect of age on the dose of remifentanil for tracheal intubation in infants and children
Paediatric Anaesthesia
DOI: 10.1111/j.1460-9592.2009.03190.x
2010

Slower administration of propofol preserves adequate respiration in children
Paediatric Anaesthesia
DOI: 10.1111/j.1460-9592.2010.03398.x
2010

Pictures worthy of a thousand words | Des images qui valent mille mots
Canadian Journal of Anesthesia
DOI: 10.1007/s12630-010-9358-5
2010

Electronic and paper diary recording of infant and caregiver behaviors
Journal of Developmental and Behavioral Pediatrics
DOI: 10.1097/DBP.0b013e3181e416ae
2010

Extreme premature birth is not associated with impaired development of brain microstructure
Journal of Pediatrics
DOI: 10.1016/j.jpeds.2010.05.026
2010

Pooled analysis of trials may, in the presence of heterogeneity inadvertently lead to fragile conclusions due to the importance of clinically relevant variables being either hidden or lost when the findings are pooled
Thrombosis Research
DOI: 10.1016/j.thromres.2010.05.009
2010

Designing and implementing a longitudinal study of children with neurological, genetic or metabolic conditions: Charting the territory
BMC Pediatrics
DOI: 10.1186/1471-2431-10-67
2010

Brief report: Maternal kangaroo care for neonatal pain relief: A systematic narrative review
Journal of Pediatric Psychology
DOI: 10.1093/jpepsy/jsp123
2010

Skin conductance fluctuations correlate poorly with postoperative self-report pain measures in school-aged children
Anesthesiology
DOI: 10.1097/ALN.0b013e3181de6ce9
2010

Effect of angiotensin-converting enzyme inhibition on C-reactive protein levels: The Ramipril C-Reactive pRotein Randomized evaluation (4R) trial results
Canadian Journal of Cardiology
2009

Comparison of the 20-Hour Intravenous and 72-Hour Oral Acetylcysteine Protocols for the Treatment of Acute Acetaminophen Poisoning
Annals of Emergency Medicine
DOI: 10.1016/j.annemergmed.2009.05.010
2009

Effect of chorioamnionitis on brain development and injury in premature newborns
Annals of Neurology
DOI: 10.1002/ana.21713
2009

The Attitudes of Canadian Maternity Care Practitioners Towards Labour and Birth: Many Differences but Important Similarities
Journal of Obstetrics and Gynaecology Canada
DOI: 10.1016/S1701-2163(16)34301-8
2009

Visual cueing with context relevant information for reducing change blindness
Journal of Clinical Monitoring and Computing
DOI: 10.1007/s10877-009-9186-8
2009

Home Therapy of Venous Thrombosis with Long-term LMWH versus Usual Care: Patient Satisfaction and Post-thrombotic Syndrome
American Journal of Medicine
DOI: 10.1016/j.amjmed.2008.12.023
2009

To the editor
Pediatrics
DOI: 10.1542/peds.2008-3324
2009

"Preventive induction" fails to demonstrate benefits for mothers or newborn infants
American Journal of Obstetrics and Gynecology
DOI: 10.1016/j.ajog.2008.08.025
2009

Do educational materials change knowledge and behaviour about crying and shaken baby syndrome? A randomized controlled trial
CMAJ
DOI: 10.1503/cmaj.081419
2009

The impact of the Canadian Hypertension Education Programme in its first decade
European Heart Journal
DOI: 10.1093/eurheartj/ehp192
2009

Increases in Antihypertensive Prescriptions and Reductions in Cardiovascular Events in Canada
Hypertension
DOI: 10.1161/HYPERTENSIONAHA.108.119784
2009

Epinephrine and dexamethasone in children with bronchiolitis
New England Journal of Medicine
DOI: 10.1056/NEJMoa0900544
2009

Improving outcomes for ill and injured children in emergency departments: Protocol for a program in pediatric emergency medicine and knowledge translation science
Implementation Science
DOI: 10.1186/1748-5908-4-60
2009

Remifentanil for tracheal intubation in infants and children
Canadian Journal of Anesthesia/Journal canadien d'anesthésie
Jon McCormack and Helen Hume-Smith and Disha Mehta and Rollin Brant and Carolyne Montgomery and Mark Ansermino
DOI: 10.1007/bf03016384
06/2008

Minimal clinically important difference for 7 measures of fatigue in patients with systemic lupus erythematosus
Journal of Rheumatology
2008

A randomized, controlled, crossover study of a noncustomized tongue retaining device for sleep disordered breathing
Sleep and Breathing
DOI: 10.1007/s11325-008-0187-5
2008

Hepatocellular carcinoma incidence trends in Canada: Analysis by birth cohort and period of diagnosis
Liver International
DOI: 10.1111/j.1478-3231.2008.01704.x
2008

Accuracy of detecting changes in auditory heart rate in a simulated operating room environment
Anaesthesia
DOI: 10.1111/j.1365-2044.2008.05629.x
2008

Determination of the minimal clinically important difference for seven fatigue measures in rheumatoid arthritis
Journal of Clinical Epidemiology
DOI: 10.1016/j.jclinepi.2007.08.016
2008

Problems of multiplicity | Problèmes de multiplicité
Canadian Journal of Anesthesia
2008

Effects of an enhanced secondary prevention program for patients with heart disease: A prospective randomized trial
Canadian Journal of Cardiology
Steven M. Edworthy and Bonnie Baptie and Donna Galvin and Rollin F. Brant and Terry Churchill-Smith and Dante Manyari and Israel Belenkie
DOI: 10.1016/s0828-282x(07)70875-9
11/2007

Injury mortality rates in native and non-native children: A population-based study
Public Health Reports
2007

Women's Pain Experience Predicts Future Surgery for Pain Associated With Endometriosis
Journal of Obstetrics and Gynaecology Canada
DOI: 10.1016/S1701-2163(16)32689-5
2007

Self-Managed Long-Term Low-Molecular-Weight Heparin Therapy: The Balance of Benefits and Harms
American Journal of Medicine
DOI: 10.1016/j.amjmed.2006.03.030
2007

The Western Canada Waiting List Project: Development of a priority referral score for hip and knee arthroplasty
Journal of Evaluation in Clinical Practice
DOI: 10.1111/j.1365-2753.2006.00671.x
2007

Effects of an enhanced secondary prevention program for patients with heart disease: A prospective randomized trial
Canadian Journal of Cardiology
2007

Sample size calculations in randomized trials: Common pitfalls | Calculs de la taille des échantillons dans les études randomisées: Pièges fréquents
Canadian Journal of Anesthesia
2007

Potential and readiness for video-visits in rural palliative homecare: results of a multi-method study in Canada
Journal of Telemedicine and Telecare
Marilynne A Hebert and Rollin Brant and David Hailey and Marjon Van Der Pol
DOI: 10.1258/135763306779380093
11/2006

Potential and readiness for video-visits in rural palliative homecare: Results of a multi-method study in Canada
Journal of Telemedicine and Telecare
2006

Long-term Low-Molecular-Weight Heparin versus Usual Care in Proximal-Vein Thrombosis Patients with Cancer
American Journal of Medicine
DOI: 10.1016/j.amjmed.2006.02.022
2006

Kaplan-Meier methods yielded misleading results in competing risk scenarios
Journal of Clinical Epidemiology
DOI: 10.1016/j.jclinepi.2006.07.002
2006

A novel imaging technique to measure capillary-refill time: Improving diagnostic accuracy for dehydration in young children with gastroenteritis
Pediatrics
DOI: 10.1542/peds.2006-1108
2006

A cluster randomized controlled trial comparing three methods of disseminating practice guidelines for children with croup [ISRCTN73394937]
Implementation Science
DOI: 10.1186/1748-5908-1-10
2006

Periodontal disease and spontaneous preterm birth: A case control study
BMC Pregnancy and Childbirth
DOI: 10.1186/1471-2393-6-24
2006

Ordinal regression model and the linear regression model were superior to the logistic regression models
Journal of Clinical Epidemiology
DOI: 10.1016/j.jclinepi.2005.09.007
2006

The impact of the Canadian Hypertension Education Program on antihypertensive prescribing trends
Hypertension
DOI: 10.1161/01.HYP.0000196269.98463.fd
2006

Association of postoperative complications with hospital costs and length of stay in a tertiary care center
Journal of General Internal Medicine
DOI: 10.1111/j.1525-1497.2006.00319.x
2006

Peripartum myocardial ischemia: A review of Canadian deliveries from 1970 to 1998
American Journal of Obstetrics and Gynecology
DOI: 10.1016/j.ajog.2005.10.795
2006

Assessment of mental health and illness by telephone survey: Experience with an Alberta mental health survey
Chronic Diseases in Canada
2006

The 2005 Canadian Hypertension Education Program recommendations for the management of hypertension: Part II - Therapy
Canadian Journal of Cardiology
2005

Atrial flutter and the risk of thromboembolism: A systematic review and meta-analysis
American Journal of Medicine
DOI: 10.1016/j.amjmed.2004.06.048
2005

Laparoscopy and Reported Pain among Patients with Endometriosis
Journal of Obstetrics and Gynaecology Canada
DOI: 10.1016/S1701-2163(16)30531-X
2005

Quantitative assessment of thrombus burden predicts the outcome of treatment for venous thrombosis: A systematic review
American Journal of Medicine
DOI: 10.1016/j.amjmed.2005.01.025
2005

Automated assessment of blood pressure using BpTRU compared with assessments by a trained technician and a clinic nurse
Blood Pressure Monitoring
DOI: 10.1097/01.mbp.0000173486.44648.b2
2005

Antidepressant pharmacoepidemiology in a general population sample [6]
Journal of Clinical Psychopharmacology
DOI: 10.1097/01.jcp.0000162815.07442.5a
2005

Clinical usefulness of home oximetry compared with polysomnography for assessment of sleep apnea
American Journal of Respiratory and Critical Care Medicine
DOI: 10.1164/rccm.200310-1360OC
2005

The 2005 Canadian Hypertension Education Program recommendations for the management of hypertension: Part I - Blood pressure measurement, diagnosis and assessment of risk
Canadian Journal of Cardiology
2005

Retention of basic science knowledge: A comparison between body system-based and clinical presentation curricula
Teaching and Learning in Medicine
2004

Successes and challenges in a field-based, multi-method study of home telehealth
Journal of Telemedicine and Telecare
DOI: 10.1258/1357633042614348
2004

A randomized trial of a single dose of oral dexamethasone for mild croup
New England Journal of Medicine
DOI: 10.1056/NEJMoa033534
2004

Effect of time of administration on cholesterol-lowering by psyllium: A randomized cross-over study in normocholesterolemic or slightly hypercholesterolemic subjects
Nutrition Journal
DOI: 10.1186/1475-2891-3-17
2004

D-dimer and venous thromboembolism [2] (multiple letters)
Annals of Internal Medicine
2004

Systematic review of statistical methods used to analyze seattle angina questionnaire scores
Canadian Journal of Cardiology
2004

Health-related quality of life outcomes of patients with coronary artery disease treated with cardiac surgery, percutaneous coronary intervention or medical management
Canadian Journal of Cardiology
2004

D-Dimer for the Exclusion of Acute Venous Thrombosis and Pulmonary Embolism: A Systematic Review
Annals of Internal Medicine
2004

Bias in estimates of confidence intervals for health outcome report cards
Journal of Clinical Epidemiology
DOI: 10.1016/S0895-4356(03)00048-9
2003

Incidence, survival and risk factors for the development of veno-occlusive disease in pediatric hematopoietic stem cell transplant recipients
Bone Marrow Transplantation
DOI: 10.1038/sj.bmt.1704069
2003

Pulmonary-artery catheters in high-risk surgical patients [3] (multiple letters)
New England Journal of Medicine
DOI: 10.1056/NEJM200305153482018
2003

A decision rule for diagnostic testing in obstructive sleep apnea
American Journal of Respiratory and Critical Care Medicine
DOI: 10.1164/rccm.200112-110OC
2003

Temporal trends in antihypertensive drug prescriptions in Canada before and after introduction of the Canadian hypertension education program
Journal of Hypertension
DOI: 10.1097/00004872-200308000-00025
2003

A randomized, controlled trial of the use of pulmonary-artery catheters in high-risk surgical patients
New England Journal of Medicine
DOI: 10.1056/NEJMoa021108
2003

The frequency of complications associated with the use of multiple-dose activated charcoal
Annals of Emergency Medicine
DOI: 10.1067/mem.2003.86
2003

Differences in admission rates of children with bronchiolitis by pediatric and general emergency departments.
Pediatrics
2002

Evaluation of satisfaction with midwifery care
Midwifery
DOI: 10.1054/midw.2002.0317
2002

Multiple imputation versus data enhancement for dealing with missing data in observational health care outcome analyses
Journal of Clinical Epidemiology
DOI: 10.1016/S0895-4356(01)00433-4
2002

Comparison of outcomes of untreated carpal tunnel syndrome and asymptomatic controls in meat packers
Occupational Medicine
DOI: 10.1093/occmed/52.8.491
2002

Hexachlorobenzene exposure and the proportion of male births in Turkey 1935-1990
Reproductive Toxicology
DOI: 10.1016/S0890-6238(01)00196-4
2002

Choroid plexus tumours
British Journal of Cancer
DOI: 10.1038/sj.bjc.6600609
2002

Systematic error in the determination of nocturnal blood pressure dipping status by ambulatory blood pressure monitoring
Blood Pressure Monitoring
DOI: 10.1097/00126097-200204000-00007
2002

Prevalence of PSA testing and effect of clinical indications on patterns of PSA testing in a population-based sample of Alberta men
Chronic Diseases in Canada
2002

Chelation therapy for ischemic heart disease: A randomized controlled trial
Journal of the American Medical Association
2002

Comparison of 2 methods for calculating adjusted survival curves from proportional hazards models
Journal of the American Medical Association
2001

Risk adjustment using administrative data: Impact of a diagnosis-type indicator
Journal of General Internal Medicine
DOI: 10.1046/j.1525-1497.2001.016008519.x
2001

Extended out-of-hospital low-molecular-weight heparin prophylaxis against deep venous thrombosis in patients after elective hip arthroplasty: A systematic review
Annals of Internal Medicine
2001

Accuracy and speed of urine pregnancy tests done in the emergency department: A prospective study
Canadian Journal of Emergency Medicine
2001

Timing of initial administration of low-molecular-weight heparin prophylaxis against deep vein thrombosis in patients following elective hip arthroplasty: A systematic review
Archives of Internal Medicine
2001

Dalteparin vs warfarin in hip arthroplasty patients [8]
Archives of Internal Medicine
2001

Poor long-term survival after coronary angiography in patients with renal insufficiency
American Journal of Kidney Diseases
2001

Timing of initial administration of low-molecular-weight heparin prophylaxis against deep vein thrombosis in patients following elective hip arthroplasty: A systematic review
Archives of Internal Medicine
2001

Prognostic significance of diabetes as a predictor of survival after cardiac catheterization
The American Journal of Medicine
William A Ghali and Hude Quan and Colleen M Norris and Vladimir Dzavik and C.David Naylor and L.Brent Mitchell and Rollin Brant and Merril L Knudtson
DOI: 10.1016/s0002-9343(00)00543-x
11/2000

Effect on lipid, complete blood count and blood proteins of a standardized preparation for drawing blood: A randomized controlled trial
Clinical and Investigative Medicine
2000

A Canadian comparison of data sources for coronary artery bypass surgery outcome 'report cards'
American Heart Journal
DOI: 10.1067/mhj.2000.109222
2000

Prognostic significance of diabetes as a predictor of survival after cardiac catheterization
American Journal of Medicine
DOI: 10.1016/S0002-9343(00)00543-X
2000

Automated analysis of digital oximetry in the diagnosis of obstructive sleep apnoea
Thorax
DOI: 10.1136/thorax.55.4.302
2000

The relationship between COMT genotype and the clinical effectiveness of tolcapone, a COMT inhibitor, in patients with Parkinson's disease
Clinical Neuropharmacology
DOI: 10.1097/00002826-200005000-00003
2000

Is there enough evidence that low-molecular-weight heparin is superior to unfractionated heparin in pulmonary embolism? [5] (multiple letters)
Archives of Internal Medicine
2000

Low-molecular-weight heparin prophylaxis using dalteparin in close proximity to surgery vs warfarin in hip arthroplasty patients a double-blind, randomized comparisons
Archives of Internal Medicine
2000

Low-molecular-weight heparin vs heparin in the treatment of patients with pulmonary embolism
Archives of Internal Medicine
2000

Prediabetes and perinatal mortality
Diabetes Care
2000

Low-molecular-weight heparin prophylaxis using dalteparin extended out- of-hospital vs in-hospital warfarin/out-of-hospital placebo in hip arthroplasty patients a double-blind, randomized comparison
Archives of Internal Medicine
2000

Mortality and institutionalization following hip fracture
Journal of the American Geriatrics Society
2000

A randomized trial of the effect of low molecular weight heparin vs. warfarin on mortality in the long-term treatment of proximal vein thrombosis
Intensivmedizin und Notfallmedizin
2000

Prevalence and incidence of carpal tunnel syndrome in a meat packing plant
Occupational and Environmental Medicine
1999

Examining the minimum important difference
Statistics in Medicine
DOI: 10.1002/(SICI)1097-0258(19991015)18:19<2593::AID-SIM392>3.0.CO;2-T
1999

Preoperative vs postoperative initiation of low-molecular-weight heparin prophylaxis against venous thromboembolism in patients undergoing elective hip replacement
Archives of Internal Medicine
DOI: 10.1001/archinte.159.2.137
1999

CABG in Canada [1]
CMAJ
1999

Coronary artery bypass grafting in Canada: Hospital mortality rates, 1992-1995
CMAJ
1998

Evaluation of reproductive outcomes in women inadvertently exposed to hexachlorobenzene in southeastern Turkey in the 1950s
Reproductive Toxicology
DOI: 10.1016/S0890-6238(98)00019-7
1998

The pulmonary artery catheter takes a great fall
Critical Care Medicine
DOI: 10.1097/00003246-199807000-00037
1998

Fluctuations in blood lipid levels during furosemide therapy: A randomized, double-blind, placebo-controlled crossover study
Archives of Internal Medicine
DOI: 10.1001/archinte.158.13.1461
1998

Prevalence and incidence of stenosing flexor tenosynovitis (trigger finger) in a meat-packing plant
Journal of Occupational and Environmental Medicine
DOI: 10.1097/00043764-199806000-00008
1998

Cuing effect of 'all of the above' on the reliability and validity of multiple-choice test items
Evaluation and the Health Professions
DOI: 10.1177/016327879802100106
1998

Compliance of clinical stage I nonseminomatous germ cell tumor patients with surveillance
Journal of Urology
DOI: 10.1016/S0022-5347(01)62782-4
1998

Coronary artery bypass grafting in Canada: National and provincial mortality trends, 1992-1995
CMAJ
1998

A clinical study of the relationship between silicone breast implants and connective tissue disease
Journal of Rheumatology
1998

Different effects of heparin in males and females
Clinical and Investigative Medicine
1998

Relation between the time to achieve the lower limit of the APTT therapeutic range and recurrent venous thromboembolism during heparin treatment for deep vein thrombosis
Archives of Internal Medicine
1997

Sorbitol 2.5% mannitol 0.54% irrigation solution for hysteroscopic endometrial ablation surgery
Canadian Journal of Anaesthesia
DOI: 10.1007/BF03011933
1997

Interaction of cross-sectional area, driving pressure, and airflow of passive velopharynx
Journal of Applied Physiology
1997

Treatment of proximal vein thrombosis with subcutaneous low-molecular- weight heparin vs intravenous heparin: An economic perspective
Archives of Internal Medicine
1997

Subcutaneous low-molecular-weight heparin vs warfarin for prophylaxis of deep vein thrombosis after hip or knee implantation: An economic perspective
Archives of Internal Medicine
1997

Declining sex ratios in Canada
CMAJ
1997

The importance of initial heparin treatment on long-term clinical outcomes of antithrombotic therapy: The emerging theme of delayed recurrence
Archives of Internal Medicine
1997

Reduction in blood culture contamination rate by feedback to phlebotomists
Archives of Pathology and Laboratory Medicine
1997

Digesting Logistic Regression Results
The American Statistician
Rollin Brant
DOI: 10.2307/2684422
05/1996

Increased use of cardiovascular medications in seniors prescribed non-ASA non-steroidal anti-inflammatory drugs
Clinical and Investigative Medicine
1996

Aging and heparin-related bleeding
Archives of Internal Medicine
DOI: 10.1001/archinte.156.8.857
1996

Smoking and Middle Ear Disease
Otolaryngology- Head and Neck Surgery
DOI: 10.1016/S0194-59989670117-1
1996

Zidovudine absorption and small intestinal function in HIV seropositive patients
Journal of Antimicrobial Chemotherapy
DOI: 10.1093/jac/37.4.825
1996

Nonrespiratory predictor of mechanical ventilation dependency in intensive care unit patients
Critical Care Medicine
DOI: 10.1097/00003246-199604000-00009
1996

Nonrespiratory predictor of mechanical ventilation dependency in intensive care unit patients
Respiratory Care
1996

A Randomized, Controlled Trial of Nurse-Midwifery Care
Birth
1996

Effect of Low Molecular Weight heparin versus warfarin sodium on mortality in long-term treatment of proximal vein thrombosis
Clinical and Applied Thrombosis/Hemostasis
1996

Digesting logistic regression results
American Statistician
1996

Prevalence of gastroesophageal reflux symptoms in asthma
Chest
1996

Disease-specific quality of life: The gallstone impact checklist
Clinical and Investigative Medicine
1996

Pulmonary artery flow directed catheter: The evidence
Lancet
1996

Freezing influences the healing of rabbit medial collateral ligament autografts
Clinical Orthopaedics and Related Research
1995

The Low-Probability Lung Scan: A Need for Change in Nomenclature
Archives of Internal Medicine
DOI: 10.1001/archinte.1995.00430170033004
1995

Soft-tissue “flaws” are associated with the material properties of the healing rabbit medial collateral ligament
Journal of Orthopaedic Research
DOI: 10.1002/jor.1100130617
1995

Intraoperative graft tensioning alters viscoelastic but not failure behaviours of rabbit medial collateral ligament autografts
Journal of Orthopaedic Research
DOI: 10.1002/jor.1100130616
1995

The Treatment of Proximal Vein Thrombosis with Subcutaneous Low-Mole Molecular-Weight Heparin Compared with Continuous Intravenous Heparin
Clinical and Applied Thrombosis/Hemostasis
DOI: 10.1177/107602969500100208
1995

Hyperglycemia in diarrhea-associated hemolytic-uremic syndrome
Nephron
1995

Human embryo implantation following in-vitro fertilization: Is there a seasonal variation?
Human Reproduction
1995

Government, university, and community collaboration to develop a cardiac surgery database and report of morbidity and mortality while waiting for open heart surgery.
Medinfo. MEDINFO
1995

Likelihood ratios for a sleep apnea clinical prediction rule
American Journal of Respiratory and Critical Care Medicine
1994

Influence of methodologie factors in a pooled analysis of 13 case-control studies of colorectal cancer and dietary fiber
Epidemiology
1994

Case-control study of prenatal ultrasonography exposure in children with delayed speech
Obstetrical and Gynecological Survey
1994

The P1 blood group and the severity of diarrhea-associated hemolytic uremic syndrome
Clinical Nephrology
1994

Hypoxia similarly impairs metabolic responses to cutaneous and core cold stimuli in conscious rats
Journal of Applied Physiology
1994

Thigh muscle strength in preadolescent girls
Clinical Journal of Sport Medicine
1994

An alternative method for determination of the carpal height ratio
Journal of Bone and Joint Surgery - Series A
1994

Detecting treatment effects in patients with rheumatoid arthritis: The advantage of longitudinal data
Journal of Rheumatology
1993

Negation in Stems of Single-Response Multiple-Choice Items: An Overestimation of Student Ability
Evaluation & the Health Professions
DOI: 10.1177/016327879301600307
1993

Relationship of the recovery in the glomerular filtration rate to the duration of anuria in diarrhea-associated hemolytic uremic syndrome
American Journal of Nephrology
DOI: 10.1159/000168617
1993

Diarrhea-associated hemolytic uremic syndrome.
Canadian Family Physician
1993

A comparison of subcutaneous low-molecular-weight heparin with warfarin sodium for prophylaxis against deep-vein thrombosis after hip or knee implantation
New England Journal of Medicine
1993

Case-control study of prenatal ultrasonography exposure in children with delayed speech
CMAJ
1993

The clinical prediction of sleep apnea
Sleep
1993

Subcutaneous low-molecular-weight heparin compared with continuous intravenous heparin in the treatment of proximal-vein thrombosis
Obstetrical and Gynecological Survey
1992

Evaluation of Negation in Stems of Multiple-Choice Items
Evaluation & the Health Professions
DOI: 10.1177/016327879201500205
1992

Lower mortality in cancer patients treated with low-molecular-weight versus standard heparin
The Lancet
DOI: 10.1016/0140-6736(92)92064-M
1992

Comparison of plain with pH-adjusted bupivacaine with hyaluronidase for peribulbar block
Canadian Journal of Anaesthesia
DOI: 10.1007/BF03008317
1992

Optimal Therapeutic Level of Heparin Therapy in Patients With Venous Thrombosis
Archives of Internal Medicine
DOI: 10.1001/archinte.1992.00400200027006
1992

Subcutaneous low-molecular-weight heparin compared with continuous intravenous heparin in the treatment of proximal-vein thrombosis
New England Journal of Medicine
1992

The relationship of the admission hemoglobin to prognosis in children with D+ hemolytic uremic syndrome[4]
Clinical Nephrology
1991

Proteinuria and prognosis in hemolytic-uremic syndrome
The Journal of Pediatrics
DOI: 10.1016/S0022-3476(05)80319-1
1991

Assessing proportionality in the proportional odds model for ordinal logistic regression
Biometrics
1990

Comparing classical and resistant outlier rules
Journal of the American Statistical Association
DOI: 10.1080/01621459.1990.10474979
1990

Sample sizes for needles in a haystack: The case of HIV seroprevalence surveys
Canadian Journal of Public Health
1990

Diphtheria-tetanus overimmunization in children with no records: can it be prevented?
CMAJ
1989

A Bayesian approach to outlier detection and residual analysis
Biometrika
DOI: 10.1093/biomet/75.4.651
1988

Residual components in generalized linear models
Canadian Journal of Statistics
DOI: 10.2307/3315200
1987

Comment
Statistical Science
DOI: 10.1214/ss/1177013626
1986

Bayesian incorporation of repeated measurements in logistic discrimination
Canadian Journal of Statistics
DOI: 10.2307/3314805
1986

Research

Current Project
Since my arrival at BC Children's Hospital Research Institute, I've had the opportunity to contribute to research initiatives in diverse areas, including analgesia in pre-term infants, determinants of word recognition memory in human newborns, effects of prenatal SSRI (anti-depressant) exposure on neurobehavioural development, and costs and benefits of antepartum home care for complicated pregnancies.