Overview

Dr. Evelyn Stewart is an Associate Professor in the Department of Psychiatry, University of British Columbia and is the founding director of the Pediatric Obsessive-Compulsive Disorder Clinic and Research Program at BC Children and Women’s Health Centre. She is a clinical, genetic and neuroscience researcher, as well as a child and adolescent psychiatrist.

Her research focuses on biologic, phenotypic, familial, and treatment aspects of childhood-onset neuropsychiatric disorders, such as obsessive-compulsive disorder (OCD). Dr. Stewart has authored over 70 original papers, reviews and chapters on genetic, clinical, and treatment aspects of OCD, Tourette's Disorder, and related illnesses. She sits on the Scientific and Clinical Advisory Board of the International OCD Foundation and was previously on the Medical Advisory Board of the Tourette Syndrome Association of America and Co-director of the International OCD Foundation Genetics Collaborative.

At BCCHR, she leads the BB&D theme and co-leads the MH group.

Publications

Long-term outcome of pediatric obsessive--compulsive disorder: a meta-analysis and qualitative review of the literature
Acta Psychiatrica Scandinavica
2004

Cognitive inflexibility and frontal-cortical activation in pediatric obsessive-compulsive disorder
Journal of the American Academy of Child & Adolescent Psychiatry
2010

Genome-wide association study of Tourette's syndrome
Molecular psychiatry
2013

A Multisite Study of Family Functioning Impairment in Pediatric Obsessive-Compulsive Disorder
Journal of the American Academy of Child & Adolescent Psychiatry
S. Evelyn Stewart and Yu-Pei Hu and Aldrich Leung and Elaine Chan and Dianne M. Hezel and Sarah Yao Lin and Laura Belschner and Casey Walsh and Daniel A. Geller and David L. Pauls
DOI: 10.1016/j.jaac.2016.12.012
03/2017

Standard of proof and intolerance of uncertainty in obsessive-compulsive disorder and social anxiety disorder
Journal of Behavior Therapy and Experimental Psychiatry
Dianne M. Hezel and S. Evelyn Stewart and Bradley C. Riemann and Richard J. McNally
DOI: 10.1016/j.jbtep.2019.02.002
09/2019

Neuroscientifically informed formulation and treatment planning for patients with obsessive-compulsive disorder: a review
JAMA Psychiatry
08/2018

Symptom insight in pediatric obsessive-compulsive disorder: Outcomes of an international aggregated cross-sectional sample
Journal of American Academy of Child and Adolescent Psychiatry
08/2018

Academic Skills in Pediatric Obsessive-Compulsive Disorder
Annals of Clinical Psychiatry
08/2018

Clarifying the Thought-Action Fusion Bias in Obsessive-Compulsive Disorder
Journal of Obsessive-Compulsive and Related Disorders. (in press)
08/2018

Significant concordance of the genetic variation that increases both the risk for OCD and the volumes of the nucleus accumbens and putamen
Br J Psychiatry
07/2018

Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis
Molecular Psychiatry
05/2018

A Case-Control Study of Sleep Disturbances in Pediatric Obsessive-Compulsive Disorder
Journal of Anxiety Disorders
04/2018

Neurocognitive Function in Pediatric Obsessive-Compulsive Disorder
World Journal of Biological Psychiatry
02/2018

Group Family-Based Cognitive Behavioral Therapy for Pediatric Obsessive Compulsive Disorder: Global Outcomes and Predictors of Improvement
Psychiatry Research
02/2018

Self-reported executive function and hoarding in adults with obsessive-compulsive disorder
Comprehensive Psychiatry
02/2018

Use of subclinical phenotypes in neuroimaging
Journal of the American Academy of Child and Adolescent Psychiatry
01/2018

Challenges in the Diagnosis and Treatment of Pediatric OCD.
Indian Journal of Psychiatry
2018

Relapse prevention strategies and guidance on refractory cases
The Clinician’s Guide to the Treatment and Management of Youth with Tourette Syndrome and Tic Disorders
2018

“OCD is Not the Boss of Me” A Practical Clinician’s Guide to Cognitive Behavioral Therapy for Pediatric Obsessive-Compulsive Disorder
Guildford Press
2018

“OCD is Not the Boss of Me” A Practical Clinician’s Guide to Cognitive Behavioral Therapy for Pediatric Obsessive-Compulsive Disorder
Guildford Press
2018

Coercive and Disruptive Behaviors Mediate Cognitive-Behavioral Therapy Response in Pediatric Obsessive-Compulsive Disorder
Comprehensive Psychiatry
2018

Cognitive planning neural correlates in a pediatric monozygotic twin pair discordant for obsessive-compulsive disorder: Exploring potential application in Precision Medicine
Journal of Clinical Psychiatry
12/2017

Parent perspectives on brain scans and genetic tests for OCD: Talking of difficult presents, desired pasts, and imagined futures
BioSocieties
12/2017

Cortical Abnormalities Associated with Pediatric and Adult Obsessive-Compulsive Disorder: Findings from the Enigma Obsessive-Compulsive Disorder Working Group
American Journal of Psychiatry
12/2017

Integrating evolutionary and regulatory information with multispecies approach implicates genes and pathways in obsessive-compulsive disorder.
Nature Communications
10/2017

Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis.
Molecular Psychiatry
08/2017

Polygenic Risk Score and Heritability Estimates Reveals a Genetic Relationship between ASD and OCD
Eur Neuropsychopharmacol
07/2017

Obsessive-Compulsive Disorder in College Athletes
Am J Psychiatry
06/2017

An Investigation of Doubt in Obsessive-Compulsive Disorder
Comprehensive Psychiatry
05/2017

Prevalence of acute-onset subtypes in pediatric obsessive-compulsive disorder
J Child Adolesc Psychopharamcol
05/2017

Genome wide association study (GWAS) between attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD)
Frontiers in Molecular Neuroscience
03/2017

A Multi-Site Study of Family Functioning Impairment in Pediatric Obsessive-Compulsive Disorder
J Am Acad of Child & Adoles Psychiatry
03/2017

Neurocognitive Function in Pediatric Obsessive-Compulsive Disorder
World Journal of Biological Psychiatry
02/2017

Parental bonding and hoarding in obsessive-compulsive disorder
Compr Psychiatry
02/2017

Rare Synaptogenesis-Impairing Mutations in SLITRK5 Are Associated with Obsessive Compulsive Disorder
PLoS One
01/2017

Biological Models and Treatments for OCD in Adults
The Wiley Handbook of Obsessive-Compulsive Disorder, 2 Volume Set
2017

Treatment of Pediatric Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder: Phenomenology, Pathophysiology and Treatment.
2017

Predictors of Comorbid Obsessive-Compulsive Disorder and Skin-Picking
Ann Clin Psychiatry
11/2016

ADHD and executive functioning deficits in OCD youths who hoard
J Psychiatr Res
11/2016

The process of parental adaptation and implications for genetic counseling. 
Journal of Genetic Counseling.
10/2016

Obsessive-Compulsive Disorder
Psychiatric Neurotherapeutics
Stewart, S Evelyn
2016

Obsessive-Compulsive and Related Disorders
MGH: Comprehensive Clinical Psychiatry
2016

Obsessive-Compulsive Disorder
The Medical Basis of Psychiatry
2016

Obsessive Compulsive Disorder
Psychiatric Neurotherapeutics: Contemporary Surgical & Device-Based Treatments in Psychiatry
2016

Examining the Psychometric Properties of the Pediatric Quality of Life Enjoyment and Satisfaction Questionnaire in Two Samples of Youth with OCD
Child Psychiatry & Human Development
2016

Factors associated with practitioners’ use of exposure therapy for childhood anxiety disorders
Journal of anxiety disorders
2016

Obsessive compulsive disorder
The Medical Basis of Psychiatry
Murphy, Tanya K and Stewart, S Evelyn and Obregon, Demian
2016

Elevated Autism Spectrum Disorder Traits in Young Children with OCD
Child Psychiatry & Human Development
2016

Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS
Molecular psychiatry
2015

Obsessive-Compulsive Disorder: The Process of Parental Adaptation and Implications for Genetic Counseling
Journal of genetic counseling
2015

Multi-Site Study of Family Functioning Impairment in Pediatric Obsessive-Compulsive Disorder
62nd Annual Meeting
2015

Tics, Other Comorbidities, and Their Implications in Pediatric Obsessive Compulsive Disorder
62nd Annual Meeting
2015

Tic-Related Obsessive Compulsive Disorder: Clinical Implications of the New DSM-5 Specifier
62nd Annual Meeting
2015

Whole-genome association analysis of treatment response in obsessive-compulsive disorder
Molecular psychiatry
2015

Social and Behavioural Research in Clinical Genetics
CLINICAL GENETICS
2015

COMT and MAO-A polymorphisms and obsessive-compulsive disorder: a family-based association study
PloS one
2015

Parent perspectives on biomarkers for OCD: Talking of difficult presents, desired pasts, and imagined futures
Biosocieties
2015

Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette’s syndrome and OCD
American Journal of Psychiatry
2015

Evaluating a unique, specialist psychiatric genetic counseling clinic: uptake and impact
Clinical genetics
2015

Brain white matter integrity and association with age at onset in pediatric obsessive-compulsive disorder
Biology of mood & anxiety disorders
2014

Psychopharmacological approaches to child and adolescent obsessive-compulsive disorder and obsessive-compulsive spectrum disorders
Obsessive Compulsive Disorder and its Spectrum: A Life-Span Approach
2014

Hoarding behavior among young children with obsessive--compulsive disorder
Journal of obsessive-compulsive and related disorders
2014

Group music therapy for severe mental illness: a randomized embedded-experimental mixed methods study
Acta Psychiatrica Scandinavica
2014

Journal of Obsessive-Compulsive and Related Disorders
2014

Hoarding in children and adolescents with obsessive--compulsive disorder
Journal of obsessive-compulsive and related disorders
2014

Pharmacotherapy for obsessive-compulsive and related disorders among children and adolescents.
2014

Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study
Journal of the American Academy of Child & Adolescent Psychiatry
2014

Parent and Child Perspectives of Family-Functioning in Pediatric Obsessive Compulsive Disorder
61st Annual Meeting
2014

Clinical correlates and genetic linkage of social and communication difficulties in families with obsessive--compulsive disorder: Results from the OCD Collaborative Genetics Study
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
2014

Validation of the university of São paulo’s sensory phenomena scale—english version
Comprehensive psychiatry
2014

Obsessions of child murder: underrecognized manifestations of obsessive-compulsive disorder
Journal of the American Academy of Psychiatry and the Law Online
2014

Genome-wide association study of obsessive-compulsive disorder
Molecular psychiatry
2013

Structure and Morphology of Copper Phthalocyanine Films on Graphene and Graphite
APS March Meeting Abstracts
2013

Gender specific short stature in male adolescents with obsessive-compulsive disorder
Journal of Obsessive-Compulsive and Related Disorders
2013

Association between MAO-A and Obsessive-Compulsive Disorder related phenotypes
Journal of Obsessive-Compulsive and Related Disorders
2013

Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture
PLoS Genet
2013

A case report of obsessive-compulsive disorder following acute disseminated encephalomyelitis
Pediatrics
2013

Meta-analysis of association between obsessive-compulsive disorder and the 3' region of neuronal glutamate transporter gene SLC1A1
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
2013

Assessment and medication management of paediatric obsessive-compulsive disorder
Drugs
2012

Genome-Wide Association Study of Gilles de la Tourette Syndrome (IN10-1.002)
Neurology
2012

Genome-Wide Association Study of Gilles de la Tourette Syndrome (S32. 006)
Neurology
2012

Journal of Obsessive-Compulsive and Related Disorders
2012

Pharmacologic Management of Treatment-Resistant Pediatric Obsessive Compulsive Disorder
59th Annual Meeting
2012

Rage takes center stage: focus on an underappreciated aspect of pediatric obsessive-compulsive disorder
Journal of the American Academy of Child & Adolescent Psychiatry
2012

Association between polymorphisms in GRIK2 gene and obsessive-compulsive disorder: a family-based study
CNS neuroscience & therapeutics
2011

Neurobiology of Obsessive-Compulsive Disorder
Pediatric Psychopharmacology
2011

Obsessive Compulsive Disorder (Clinical Features, Treatment Algorithms, Assessment)
Neurotherapeutics
2011

Neurobiology of Obsessive-Compulsive Disorder
Pediatric Psychopharmacology
2011

Obsessive Compulsive Disorder (Clinical Features, Treatment Algorithms, Assessment)
Neurotherapeutics
2011

Influenza vaccination responses in human systemic lupus erythematosus: impact of clinical and demographic features
Arthritis & Rheumatism
2011

Short Stature in Male Adolescents with Obsessive Compulsive Disorder
AACAP+ CACAP Joint Annual Meeting (October 18-23, 2011)
2011

Clinical Correlates and Specific Symptom Predictors of Family Functioning Impairment in Obsessive Compulsive Disorder
AACAP+ CACAP Joint Annual Meeting (October 18-23, 2011)
2011

Meta-Analysis of Association Between the Neuronal Glutamate Transporter Gene SLC1A1 and Obsessive Compulsive Disorder
AACAP+ CACAP Joint Annual Meeting (October 18-23, 2011)
2011

Development and psychometric properties of the OCD Family Functioning (OFF) Scale.
Journal of Family Psychology
2011

Latent class analysis of the Yale-Brown Obsessive-Compulsive Scale symptoms in obsessive-compulsive disorder
Comprehensive psychiatry
2011

The familial association of tourette's disorder and ADHD: the impact of OCD symptoms
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
2011

Family-based genetic association study of DLGAP3 in Tourette Syndrome
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
2011

A single-blinded case-control study of memantine in severe obsessive-compulsive disorder
Journal of clinical psychopharmacology
2010

Neurobiology of obsessive-compulsive disorder
Pediatric Psychopharmacology
2010

MAO-A and COMT polymorphisms and OCD: A brazilian family-based association study
Biological Psychiatry
2010

Glutamate Modulating Agents in Treatment-Refractory Obsessive-Compulsive Disorder
BIOLOGICAL PSYCHIATRY
2010

The genetics of obsessive-compulsive disorder
Focus
2010

Amygdala activation in response to facial expressions in pediatric obsessive--compulsive disorder
Depression and anxiety
2010

Structural differences in adult orbital and ventromedial prefrontal cortex predicted by infant temperament at 4 months of age
Archives of general psychiatry
2010

Symptom dimensions in OCD: item-level factor analysis and heritability estimates
Behavior genetics
2010

A twin concordance study of trichotillomania
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
2009

Candidate Gene Association Study of DLGAP3 in Tourette Syndrome Patients
NEUROLOGY
2009

Association between GRIK2 Polymorphism and OCD: A Family-Based Study
BIOLOGICAL PSYCHIATRY
2009

The Neural Correlates of Negative Priming in Pediatric Obsessive Compulsive Disorder.
BIOLOGICAL PSYCHIATRY
2009

Gender as a Mediator of Intensive Residential Treatment Response in OCD
BIOLOGICAL PSYCHIATRY
2009

Clinical case rounds in child and adolescent psychiatry: trichotillomania-by-proxy: a possible cause of childhood alopecia
Journal of the Canadian Academy of Child and Adolescent Psychiatry
2009

Long-term outcome following intensive residential treatment of obsessive--compulsive disorder
Journal of psychiatric research
2009

Biological treatment for obsessive-compulsive disorder
Oxford handbook of anxiety and related disorders
2009

Memantine as an augmenting agent for severe pediatric OCD
American journal of psychiatry
2009

Four-factor structure of obsessive-compulsive disorder symptoms in children, adolescents, and adults
Journal of the American Academy of Child & Adolescent Psychiatry
2008

Genetics of Childhood Psychiatric Disorders
Psychiatric Genetics: Applications in Clinical Practice
2008

Biological Treatments for Obsessive-Compulsive Disorder
Oxford Handbook of Anxiety and Related Disorders
2008

Obsessive-Compulsive Disorder and OCD-Related Disorders
MGH: Comprehensive Clinical Psychiatry
2008

Biological Treatments for Obsessive-Compulsive Disorder
Oxford Handbook of Anxiety and Related Disorders
2008

Obsessive-Compulsive Disorder and OCD-Related Disorders
MGH: Comprehensive Clinical Psychiatry
2008

Genetics of childhood-onset psychiatric disorders
Psychiatric Genetics. Washington DC. American Psychiatric Publishing, Inc
Stewart, S Evelyn and Pauls, David L
2008

Predictors of family accommodation in obsessive-compulsive disorder
Annals of Clinical Psychiatry
2008

Severe obsessive-compulsive disorder with and without body dysmorphic disorder: Clinical correlates and implications
Annals of Clinical Psychiatry
2008

Lack of association between SLITRK1var321 and Tourette syndrome in a large family-based sample
Neurology
2008

A genetic family-based association study of OLIG2 in obsessive-compulsive disorder
Archives of general psychiatry
2007

Genome scan for Tourette disorder in affected-sibling-pair and multigenerational families
The American Journal of Human Genetics
2007

Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorder
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
2007

Principal components analysis of obsessive--compulsive disorder symptoms in children and adolescents
Biological psychiatry
2007

A controlled family study of attention-deficit/hyperactivity disorder and Tourette's disorder
Journal of the American Academy of Child & Adolescent Psychiatry
2006

Outcome predictors for severe obsessive--compulsive patients in intensive residential treatment
Journal of psychiatric research
2006

Severe obsessive-compulsive disorder with and without comorbid hair pulling: comparisons and clinical implications
The Journal of clinical psychiatry
2005

Controlled family study of ADHD and Tourette's disorder
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
2005

Performance of clinician versus self-report measures to identify obsessive-compulsive disorder in children and adolescents
Journal of Child & Adolescent Psychopharmacology
2005

Effectiveness of intensive residential treatment (IRT) for severe, refractory obsessive-compulsive disorder
Journal of psychiatric research
2005

Tics and tourette’s disorder: Which therapies, and when to use them
02/2003

Which SSRI? A meta-analysis of pharmacotherapy trials in pediatric obsessive-compulsive disorder
American Journal of Psychiatry
2003

Impact of comorbidity on treatment response to paroxetine in pediatric obsessive-compulsive disorder: is the use of exclusion criteria empirically supported in randomized clinical trials?
Journal of Child and Adolescent Psychopharmacology
2003

Emergency management of the adolescent suicide attempter: a review of the literature
Journal of Adolescent Health
2002

Suicidal children and adolescents with first emergency room presentations: predictors of six-month outcome
Journal of the American Academy of Child & Adolescent Psychiatry
2001

33 OCD and OCD-Related Disorders

Research

Current Projects
Neural Correlates in Childhood-onset OCD: The goal of this study is to evaluate for neurocognitive and neurosoft sign state and at-risk trait markers for OCD, by examining affected, at-risk and healthy youth.

Brain Function and Structure in Pediatric Obsessive Compulsive Disorder: The goal of this study is to examine the cortical structure and functional activation in the regions implicated in OCD in OCD-affected, OCD-unaffected siblings, and healthy children and adolescents. A planning task conducted pre- and post-symptom provocation will be used to examine the impact of symptoms on executive function. In addition, DTI will record white matter structure and organization.

As PI:

Obsessive-Compulsive Disorder (OCD) Registry and DNA Repository
Clinical Outcomes following Group-based Family Cognitive-Behaviour Therapy in Pediatric Obsessive- Compulsive Disorder (OCD).
Mindfulness Training versus Peer Support Groups for Parents of Obsessive-Compulsive Disorder
Objective measures of sleep and daily physical activity in pediatric Obsessive-Compulsive Disorder
As Co-Investigator:

Cognitive and biological underpinnings of delusions in psychosis
Trends in Psychiatric Seasonal Emergency Admission

Grants

2010-current, NIH-RO1, Perspectives on Neuroimaging and Genetics from Parents of Children with OCD. The goal is to examine experiences of parents involved in Pediatric neuroimaging studies. Role: Co-Investigator.

2012-2020, MSFHR Clinical Research Scholar Award, $90,000/year or ($635,000 for 8 years), OCD translational multi-modal research program. The goal is to create an interdisciplinary, multimodal research program within the new Pediatric OCD clinic at B.C. Children’s Hospital. Role: Principal Investigator.

2014-2016, CIHR Operating Grant, $175,485/year ($526,454 for 3 years), Neural Correlates in Childhood-onset Obsessive-Compulsive Disorder. The goal is to compare neural correlates in CO-OCD and unaffected, at-risk sibling (SIB) groups with matched healthy controls (HC), in order to evaluate both their suitability as trait markers of genetic risk (to better understand the disorder) and their potential utility in clinical settings (to better manage the disorder). Role: Principal Investigator.

Honours & Awards

2015 Nominated for Royal College’s 2015 Prix d’Excellence – Specialist of the Year Award for Region 1, Regional Advisory Committee, Canada

2015 Recommendation for Outstanding Academic Performance (OAP) by Department Head, UBC

2016 Highly Cited Researcher by Thomson Reuters

2017 Nominated for 2017 BC Children’s Hospital Research Institute Geoffrey L. Hammond Lectureship, Vancouver BC

2017 American Academy of Child and Adolescent Psychiatry (AACAP) Norbert and Charlotte Rieger Award for Scientific Achievement

2018 Distinguished Achievement Award for Excellence in Clinical and Applied Research, Faculty of Medicine, UBC

2015 BC Patient Safety & Quality Council “Quality Awards 2016” – Runner-Up for Excellence in Quality Living with Illness, Vancouver, BC (J Austin, PI)

2017 Nominated twice for CAMH (Centre for Addiction and Mental Health) Difference Makers – 150 Leading Canadians for Mental Health, Canada

2009 Nominated for Excellence in Mentoring Award for 2008-2009, Massachusetts General Hospital

2008 Research Colloquium for Junior Investigators

2008-9 Travel Awardee American College of Neuropsychopharmacology

Research Group Members

Gordan Andjelic, Research Assistant
Antony Au, Research Assistant
John Best, Biostatistician
Antyrah De Guzman, Undergraduate Research Student
Jessica Ferreira, Research Assistant
Diana Franco Yamin, Research Coordinator
Dagmar Hannesdottir
Fern Jaspers-Fayer, MSFHR Trainee
Jessica Liang, Undergraduate Research Student
Katherine McKenney, Psychologist
Zainab Naqqash, Staff, Research Assistant
Juliana Negreiros, Postdoctoral Fellow
Adeline Nejaty, Undergraduate Research Student
Robert Selles, Postdoctoral Fellow
Clara Westwell-Roper