- Overview
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Dr. Evelyn Stewart is an Associate Professor in the Department of Psychiatry, University of British Columbia and is the founding director of the Pediatric Obsessive-Compulsive Disorder Clinic and Research Program at BC Children and Women’s Health Centre. She is a clinical, genetic and neuroscience researcher, as well as a child and adolescent psychiatrist.
Her research focuses on biologic, phenotypic, familial, and treatment aspects of childhood-onset neuropsychiatric disorders, such as obsessive-compulsive disorder (OCD). Dr. Stewart has authored over 70 original papers, reviews and chapters on genetic, clinical, and treatment aspects of OCD, Tourette's Disorder, and related illnesses. She sits on the Scientific and Clinical Advisory Board of the International OCD Foundation and was previously on the Medical Advisory Board of the Tourette Syndrome Association of America and Co-director of the International OCD Foundation Genetics Collaborative.
At BCCHR, she leads the BB&D theme and co-leads the MH group.
- Publications
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Long-term outcome of pediatric obsessive--compulsive disorder: a meta-analysis and qualitative review of the literature
Acta Psychiatrica Scandinavica
2004Cognitive inflexibility and frontal-cortical activation in pediatric obsessive-compulsive disorder
Journal of the American Academy of Child & Adolescent Psychiatry
2010Genome-wide association study of Tourette's syndrome
Molecular psychiatry
2013A Multisite Study of Family Functioning Impairment in Pediatric Obsessive-Compulsive Disorder
Journal of the American Academy of Child & Adolescent Psychiatry
S. Evelyn Stewart and Yu-Pei Hu and Aldrich Leung and Elaine Chan and Dianne M. Hezel and Sarah Yao Lin and Laura Belschner and Casey Walsh and Daniel A. Geller and David L. Pauls
DOI: 10.1016/j.jaac.2016.12.012
03/2017Family Profiles in Pediatric Obsessive-Compulsive Disorder
Journal of Obsessive-Compulsive and Related Disorders
Robert R. Selles and John R. Best and S. Evelyn Stewart
DOI: 10.1016/j.jocrd.2020.100588
09/2020Mindfulness-based skills training group for parents of obsessive-compulsive disorder-affected children: A caregiver-focused intervention
Complementary Therapies in Clinical Practice
Laura Belschner and Sarah Yao Lin and Diana Franco Yamin and John R. Best and Kourosh Edalati and Joanna McDermid and S. Evelyn Stewart
DOI: 10.1016/j.ctcp.2020.101098
05/2020Standard of proof and intolerance of uncertainty in obsessive-compulsive disorder and social anxiety disorder
Journal of Behavior Therapy and Experimental Psychiatry
Dianne M. Hezel and S. Evelyn Stewart and Bradley C. Riemann and Richard J. McNally
DOI: 10.1016/j.jbtep.2019.02.002
09/2019Neuroscientifically informed formulation and treatment planning for patients with obsessive-compulsive disorder: a review
JAMA Psychiatry
08/2018Symptom insight in pediatric obsessive-compulsive disorder: Outcomes of an international aggregated cross-sectional sample
Journal of American Academy of Child and Adolescent Psychiatry
08/2018Academic Skills in Pediatric Obsessive-Compulsive Disorder
Annals of Clinical Psychiatry
08/2018Clarifying the Thought-Action Fusion Bias in Obsessive-Compulsive Disorder
Journal of Obsessive-Compulsive and Related Disorders. (in press)
08/2018Significant concordance of the genetic variation that increases both the risk for OCD and the volumes of the nucleus accumbens and putamen
Br J Psychiatry
07/2018Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis
Molecular Psychiatry
05/2018A Case-Control Study of Sleep Disturbances in Pediatric Obsessive-Compulsive Disorder
Journal of Anxiety Disorders
04/2018Neurocognitive Function in Pediatric Obsessive-Compulsive Disorder
World Journal of Biological Psychiatry
02/2018Group Family-Based Cognitive Behavioral Therapy for Pediatric Obsessive Compulsive Disorder: Global Outcomes and Predictors of Improvement
Psychiatry Research
02/2018Self-reported executive function and hoarding in adults with obsessive-compulsive disorder
Comprehensive Psychiatry
02/2018Use of subclinical phenotypes in neuroimaging
Journal of the American Academy of Child and Adolescent Psychiatry
01/2018Challenges in the Diagnosis and Treatment of Pediatric OCD.
Indian Journal of Psychiatry
2018Relapse prevention strategies and guidance on refractory cases
The Clinician’s Guide to the Treatment and Management of Youth with Tourette Syndrome and Tic Disorders
2018“OCD is Not the Boss of Me” A Practical Clinician’s Guide to Cognitive Behavioral Therapy for Pediatric Obsessive-Compulsive Disorder
Guildford Press
2018Coercive and Disruptive Behaviors Mediate Cognitive-Behavioral Therapy Response in Pediatric Obsessive-Compulsive Disorder
Comprehensive Psychiatry
2018Cognitive planning neural correlates in a pediatric monozygotic twin pair discordant for obsessive-compulsive disorder: Exploring potential application in Precision Medicine
Journal of Clinical Psychiatry
12/2017Parent perspectives on brain scans and genetic tests for OCD: Talking of difficult presents, desired pasts, and imagined futures
BioSocieties
12/2017Cortical Abnormalities Associated with Pediatric and Adult Obsessive-Compulsive Disorder: Findings from the Enigma Obsessive-Compulsive Disorder Working Group
American Journal of Psychiatry
12/2017Integrating evolutionary and regulatory information with multispecies approach implicates genes and pathways in obsessive-compulsive disorder.
Nature Communications
10/2017Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis.
Molecular Psychiatry
08/2017Polygenic Risk Score and Heritability Estimates Reveals a Genetic Relationship between ASD and OCD
Eur Neuropsychopharmacol
07/2017Obsessive-Compulsive Disorder in College Athletes
Am J Psychiatry
06/2017An Investigation of Doubt in Obsessive-Compulsive Disorder
Comprehensive Psychiatry
05/2017Prevalence of acute-onset subtypes in pediatric obsessive-compulsive disorder
J Child Adolesc Psychopharamcol
05/2017Genome wide association study (GWAS) between attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD)
Frontiers in Molecular Neuroscience
03/2017A Multi-Site Study of Family Functioning Impairment in Pediatric Obsessive-Compulsive Disorder
J Am Acad of Child & Adoles Psychiatry
03/2017Neurocognitive Function in Pediatric Obsessive-Compulsive Disorder
World Journal of Biological Psychiatry
02/2017Parental bonding and hoarding in obsessive-compulsive disorder
Compr Psychiatry
02/2017Rare Synaptogenesis-Impairing Mutations in SLITRK5 Are Associated with Obsessive Compulsive Disorder
PLoS One
01/2017Biological Models and Treatments for OCD in Adults
The Wiley Handbook of Obsessive-Compulsive Disorder, 2 Volume Set
2017Treatment of Pediatric Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder: Phenomenology, Pathophysiology and Treatment.
2017Predictors of Comorbid Obsessive-Compulsive Disorder and Skin-Picking
Ann Clin Psychiatry
11/2016ADHD and executive functioning deficits in OCD youths who hoard
J Psychiatr Res
11/2016The process of parental adaptation and implications for genetic counseling.
Journal of Genetic Counseling.
10/2016Elevated Autism Spectrum Disorder Traits in Young Children with OCD
Child Psychiatry & Human Development
2016Obsessive-Compulsive and Related Disorders
MGH: Comprehensive Clinical Psychiatry
2016Obsessive-Compulsive Disorder
The Medical Basis of Psychiatry
2016Obsessive Compulsive Disorder
Psychiatric Neurotherapeutics: Contemporary Surgical & Device-Based Treatments in Psychiatry
2016Examining the Psychometric Properties of the Pediatric Quality of Life Enjoyment and Satisfaction Questionnaire in Two Samples of Youth with OCD
Child Psychiatry & Human Development
2016Factors associated with practitioners’ use of exposure therapy for childhood anxiety disorders
Journal of anxiety disorders
2016Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS
Molecular psychiatry
2015Obsessive-Compulsive Disorder: The Process of Parental Adaptation and Implications for Genetic Counseling
Journal of genetic counseling
2015Multi-Site Study of Family Functioning Impairment in Pediatric Obsessive-Compulsive Disorder
62nd Annual Meeting
2015Tics, Other Comorbidities, and Their Implications in Pediatric Obsessive Compulsive Disorder
62nd Annual Meeting
2015Tic-Related Obsessive Compulsive Disorder: Clinical Implications of the New DSM-5 Specifier
62nd Annual Meeting
2015Whole-genome association analysis of treatment response in obsessive-compulsive disorder
Molecular psychiatry
2015Social and Behavioural Research in Clinical Genetics
CLINICAL GENETICS
2015COMT and MAO-A polymorphisms and obsessive-compulsive disorder: a family-based association study
PloS one
2015Parent perspectives on biomarkers for OCD: Talking of difficult presents, desired pasts, and imagined futures
Biosocieties
2015Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette’s syndrome and OCD
American Journal of Psychiatry
2015Evaluating a unique, specialist psychiatric genetic counseling clinic: uptake and impact
Clinical genetics
2015Brain white matter integrity and association with age at onset in pediatric obsessive-compulsive disorder
Biology of mood & anxiety disorders
2014Psychopharmacological approaches to child and adolescent obsessive-compulsive disorder and obsessive-compulsive spectrum disorders
Obsessive Compulsive Disorder and its Spectrum: A Life-Span Approach
2014Hoarding behavior among young children with obsessive--compulsive disorder
Journal of obsessive-compulsive and related disorders
2014Group music therapy for severe mental illness: a randomized embedded-experimental mixed methods study
Acta Psychiatrica Scandinavica
2014Journal of Obsessive-Compulsive and Related Disorders
2014Hoarding in children and adolescents with obsessive--compulsive disorder
Journal of obsessive-compulsive and related disorders
2014Pharmacotherapy for obsessive-compulsive and related disorders among children and adolescents.
2014Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study
Journal of the American Academy of Child & Adolescent Psychiatry
2014Parent and Child Perspectives of Family-Functioning in Pediatric Obsessive Compulsive Disorder
61st Annual Meeting
2014Clinical correlates and genetic linkage of social and communication difficulties in families with obsessive--compulsive disorder: Results from the OCD Collaborative Genetics Study
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
2014Validation of the university of São paulo’s sensory phenomena scale—english version
Comprehensive psychiatry
2014Obsessions of child murder: underrecognized manifestations of obsessive-compulsive disorder
Journal of the American Academy of Psychiatry and the Law Online
2014Genome-wide association study of obsessive-compulsive disorder
Molecular psychiatry
2013Structure and Morphology of Copper Phthalocyanine Films on Graphene and Graphite
APS March Meeting Abstracts
2013Gender specific short stature in male adolescents with obsessive-compulsive disorder
Journal of Obsessive-Compulsive and Related Disorders
2013Association between MAO-A and Obsessive-Compulsive Disorder related phenotypes
Journal of Obsessive-Compulsive and Related Disorders
2013Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture
PLoS Genet
2013A case report of obsessive-compulsive disorder following acute disseminated encephalomyelitis
Pediatrics
2013Meta-analysis of association between obsessive-compulsive disorder and the 3' region of neuronal glutamate transporter gene SLC1A1
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
2013Assessment and medication management of paediatric obsessive-compulsive disorder
Drugs
2012Genome-Wide Association Study of Gilles de la Tourette Syndrome (IN10-1.002)
Neurology
2012Genome-Wide Association Study of Gilles de la Tourette Syndrome (S32. 006)
Neurology
2012Journal of Obsessive-Compulsive and Related Disorders
2012Pharmacologic Management of Treatment-Resistant Pediatric Obsessive Compulsive Disorder
59th Annual Meeting
2012Rage takes center stage: focus on an underappreciated aspect of pediatric obsessive-compulsive disorder
Journal of the American Academy of Child & Adolescent Psychiatry
2012Association between polymorphisms in GRIK2 gene and obsessive-compulsive disorder: a family-based study
CNS neuroscience & therapeutics
2011Neurobiology of Obsessive-Compulsive Disorder
Pediatric Psychopharmacology
2011Obsessive Compulsive Disorder (Clinical Features, Treatment Algorithms, Assessment)
Neurotherapeutics
2011Influenza vaccination responses in human systemic lupus erythematosus: impact of clinical and demographic features
Arthritis & Rheumatism
2011Short Stature in Male Adolescents with Obsessive Compulsive Disorder
AACAP+ CACAP Joint Annual Meeting (October 18-23, 2011)
2011Clinical Correlates and Specific Symptom Predictors of Family Functioning Impairment in Obsessive Compulsive Disorder
AACAP+ CACAP Joint Annual Meeting (October 18-23, 2011)
2011Meta-Analysis of Association Between the Neuronal Glutamate Transporter Gene SLC1A1 and Obsessive Compulsive Disorder
AACAP+ CACAP Joint Annual Meeting (October 18-23, 2011)
2011Development and psychometric properties of the OCD Family Functioning (OFF) Scale.
Journal of Family Psychology
2011Latent class analysis of the Yale-Brown Obsessive-Compulsive Scale symptoms in obsessive-compulsive disorder
Comprehensive psychiatry
2011The familial association of tourette's disorder and ADHD: the impact of OCD symptoms
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
2011Family-based genetic association study of DLGAP3 in Tourette Syndrome
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
2011A single-blinded case-control study of memantine in severe obsessive-compulsive disorder
Journal of clinical psychopharmacology
2010Neurobiology of obsessive-compulsive disorder
Pediatric Psychopharmacology
2010MAO-A and COMT polymorphisms and OCD: A brazilian family-based association study
Biological Psychiatry
2010Glutamate Modulating Agents in Treatment-Refractory Obsessive-Compulsive Disorder
BIOLOGICAL PSYCHIATRY
2010The genetics of obsessive-compulsive disorder
Focus
2010Amygdala activation in response to facial expressions in pediatric obsessive--compulsive disorder
Depression and anxiety
2010Structural differences in adult orbital and ventromedial prefrontal cortex predicted by infant temperament at 4 months of age
Archives of general psychiatry
2010Symptom dimensions in OCD: item-level factor analysis and heritability estimates
Behavior genetics
2010A twin concordance study of trichotillomania
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
2009Candidate Gene Association Study of DLGAP3 in Tourette Syndrome Patients
NEUROLOGY
2009Association between GRIK2 Polymorphism and OCD: A Family-Based Study
BIOLOGICAL PSYCHIATRY
2009The Neural Correlates of Negative Priming in Pediatric Obsessive Compulsive Disorder.
BIOLOGICAL PSYCHIATRY
2009Gender as a Mediator of Intensive Residential Treatment Response in OCD
BIOLOGICAL PSYCHIATRY
2009Clinical case rounds in child and adolescent psychiatry: trichotillomania-by-proxy: a possible cause of childhood alopecia
Journal of the Canadian Academy of Child and Adolescent Psychiatry
2009Long-term outcome following intensive residential treatment of obsessive--compulsive disorder
Journal of psychiatric research
2009Biological treatment for obsessive-compulsive disorder
Oxford handbook of anxiety and related disorders
2009Memantine as an augmenting agent for severe pediatric OCD
American journal of psychiatry
2009Four-factor structure of obsessive-compulsive disorder symptoms in children, adolescents, and adults
Journal of the American Academy of Child & Adolescent Psychiatry
2008Genetics of Childhood Psychiatric Disorders
Psychiatric Genetics: Applications in Clinical Practice
2008Biological Treatments for Obsessive-Compulsive Disorder
Oxford Handbook of Anxiety and Related Disorders
2008Obsessive-Compulsive Disorder and OCD-Related Disorders
MGH: Comprehensive Clinical Psychiatry
2008Predictors of family accommodation in obsessive-compulsive disorder
Annals of Clinical Psychiatry
2008Severe obsessive-compulsive disorder with and without body dysmorphic disorder: Clinical correlates and implications
Annals of Clinical Psychiatry
2008Lack of association between SLITRK1var321 and Tourette syndrome in a large family-based sample
Neurology
2008A genetic family-based association study of OLIG2 in obsessive-compulsive disorder
Archives of general psychiatry
2007Genome scan for Tourette disorder in affected-sibling-pair and multigenerational families
The American Journal of Human Genetics
2007Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorder
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
2007Principal components analysis of obsessive--compulsive disorder symptoms in children and adolescents
Biological psychiatry
2007A controlled family study of attention-deficit/hyperactivity disorder and Tourette's disorder
Journal of the American Academy of Child & Adolescent Psychiatry
2006Outcome predictors for severe obsessive--compulsive patients in intensive residential treatment
Journal of psychiatric research
2006Severe obsessive-compulsive disorder with and without comorbid hair pulling: comparisons and clinical implications
The Journal of clinical psychiatry
2005Controlled family study of ADHD and Tourette's disorder
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
2005Performance of clinician versus self-report measures to identify obsessive-compulsive disorder in children and adolescents
Journal of Child & Adolescent Psychopharmacology
2005Effectiveness of intensive residential treatment (IRT) for severe, refractory obsessive-compulsive disorder
Journal of psychiatric research
2005Tics and tourette’s disorder: Which therapies, and when to use them
02/2003Which SSRI? A meta-analysis of pharmacotherapy trials in pediatric obsessive-compulsive disorder
American Journal of Psychiatry
2003Impact of comorbidity on treatment response to paroxetine in pediatric obsessive-compulsive disorder: is the use of exclusion criteria empirically supported in randomized clinical trials?
Journal of Child and Adolescent Psychopharmacology
2003Emergency management of the adolescent suicide attempter: a review of the literature
Journal of Adolescent Health
2002Suicidal children and adolescents with first emergency room presentations: predictors of six-month outcome
Journal of the American Academy of Child & Adolescent Psychiatry
200133 OCD and OCD-Related Disorders
- Research
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Current Projects
Neural Correlates in Childhood-onset OCD: The goal of this study is to evaluate for neurocognitive and neurosoft sign state and at-risk trait markers for OCD, by examining affected, at-risk and healthy youth.
Brain Function and Structure in Pediatric Obsessive Compulsive Disorder: The goal of this study is to examine the cortical structure and functional activation in the regions implicated in OCD in OCD-affected, OCD-unaffected siblings, and healthy children and adolescents. A planning task conducted pre- and post-symptom provocation will be used to examine the impact of symptoms on executive function. In addition, DTI will record white matter structure and organization.
As PI:
Obsessive-Compulsive Disorder (OCD) Registry and DNA Repository
Clinical Outcomes following Group-based Family Cognitive-Behaviour Therapy in Pediatric Obsessive- Compulsive Disorder (OCD).
Mindfulness Training versus Peer Support Groups for Parents of Obsessive-Compulsive Disorder
Objective measures of sleep and daily physical activity in pediatric Obsessive-Compulsive Disorder
As Co-Investigator:
Cognitive and biological underpinnings of delusions in psychosis
Trends in Psychiatric Seasonal Emergency AdmissionGrants2010-current, NIH-RO1, Perspectives on Neuroimaging and Genetics from Parents of Children with OCD. The goal is to examine experiences of parents involved in Pediatric neuroimaging studies. Role
Co-Investigator.
2012-2020, MSFHR Clinical Research Scholar Award, $90,000/year or ($635,000 for 8 years), OCD translational multi-modal research program. The goal is to create an interdisciplinary, multimodal research program within the new Pediatric OCD clinic at B.C. Children’s Hospital. Role
Principal Investigator.
2014-2016, CIHR Operating Grant, $175,485/year ($526,454 for 3 years), Neural Correlates in Childhood-onset Obsessive-Compulsive Disorder. The goal is to compare neural correlates in CO-OCD and unaffected, at-risk sibling (SIB) groups with matched healthy controls (HC), in order to evaluate both their suitability as trait markers of genetic risk (to better understand the disorder) and their potential utility in clinical settings (to better manage the disorder). Role
Principal Investigator.
Honours & Awards2015 Nominated for Royal College’s 2015 Prix d’Excellence – Specialist of the Year Award for Region 1, Regional Advisory Committee, Canada
2015 Recommendation for Outstanding Academic Performance (OAP) by Department Head, UBC
2016 Highly Cited Researcher by Thomson Reuters
2017 Nominated for 2017 BC Children’s Hospital Research Institute Geoffrey L. Hammond Lectureship, Vancouver BC
2017 American Academy of Child and Adolescent Psychiatry (AACAP) Norbert and Charlotte Rieger Award for Scientific Achievement
2018 Distinguished Achievement Award for Excellence in Clinical and Applied Research, Faculty of Medicine, UBC
2015 BC Patient Safety & Quality Council “Quality Awards 2016” – Runner-Up for Excellence in Quality Living with Illness, Vancouver, BC (J Austin, PI)
2017 Nominated twice for CAMH (Centre for Addiction and Mental Health) Difference Makers – 150 Leading Canadians for Mental Health, Canada
2009 Nominated for Excellence in Mentoring Award for 2008-2009, Massachusetts General Hospital
2008 Research Colloquium for Junior Investigators
2008-9 Travel Awardee American College of Neuropsychopharmacology
Research Group MembersGordan Andjelic, Research Assistant
Antony Au, Research Assistant
James Avery, Research Assistant
John Best, Biostatistician
Antyrah De Guzman, INSPIRE Student
Jessica Ferreira, Research Assistant
Diana Franco Yamin, Research Coordinator
Umara Hansen, BCCHR Summer Student Research Program Volunteer
Fern Jaspers-Fayer, MSFHR Trainee
Jessica Liang, INSPIRE Student
Sarah Lin, Theme Research Manager - Brain, Behaviour & Development
Boyee Lin, Research Assistant
Cynthia Lu, Research Assistant
Katherine McKenney, Psychologist
Zainab Naqqash, Staff, Research Assistant
Juliana Negreiros, Postdoctoral Fellow
Adeline Nejaty, INSPIRE Student
Robert Selles, Postdoctoral Fellow, Registered Psychologist
Katarina Tabi, Postdoctoral Research Fellow
Clara Westwell-Roper
The challenges of treating OCD in children: Q&A with Dr. Robert Selles
How does obsessive-compulsive disorder (OCD) manifest in children? How does it impact children and their families? How can we best treat it? Dr. Robert Selles is working to answer these questions and help children with OCD manage their symptoms so they can lead their best lives.
