Despite much effort, we know little about how the healthy child is protected from infectious disease, and even less about why some children develop inflammatory disorders. Why do some healthy children succumb to overwhelming bacterial infection, while others either survive infection or do not become infected at all? Why do some children suffer crippling juvenile arthritis or life-threatening asthma?
My research program is translational, interdisciplinary and unique in its focus on understanding the role of innate immunity in infectious and inflammatory diseases of childhood. Starting with a population of children with a defined infectious or inflammatory disease phenotype (e.g., undue susceptibility to infection, juvenile idiopathic arthritis, asthma), I aim to determine the underlying cellular, molecular and genetic abnormalities responsible for the disease through detailed immunological, genomic and proteomic analysis. The new knowledge generated by this approach will aid diagnosis, elucidate mechanisms of disease pathogenesis and, ultimately, identify novel targets for anti-inflammatory and anti-infectious therapeutic agents.
Thinking bigger: How early-life environmental exposures shape the gut microbiome and influence the development of asthma and allergic disease
Hind Sbihi and Rozlyn CT. Boutin and Chelsea Cutler and Mandy Suen and B. Brett Finlay and Stuart E. Turvey
Impact of maternal pre-pregnancy overweight on infant overweight at 1 year of age: associations and sex-specific differences
S. L. Bridgman and M. B. Azad and R. R. Persaud and R. S. Chari and A. B. Becker and M. R. Sears and P. J. Mandhane and S. E. Turvey and P. Subbarao and A. M. Haqq and A. L. Kozyrskyj
The importance of functional validation after next-generation sequencing: evaluation of a novel CARD11 variant
Pediatric Allergy and Immunology
Henry Y. Lu and Mehul Sharma and Catherine M. Biggs and Yu-Hsuan Huang and Kevin E. Shopsowitz and Patrick Frosk and John J. Priatel and Tamar S. Rubin and Stuart E. Turvey
Exclusive breastfeeding in hospital predicts longer breastfeeding duration in Canada: Implications for health equity.
Birth (Berkeley, Calif.)
Vehling L and Chan D and McGavock J and Becker AB and Subbarao P and Moraes TJ and Mandhane PJ and Turvey SE and Lefebvre DL and Sears MR and Azad MB
Roles of Birth Mode and Infant Gut Microbiota in Intergenerational Transmission of Overweight and Obesity From Mother to Offspring.
Tun HM and Bridgman SL and Chari R and Field CJ and Guttman DS and Becker AB and Mandhane PJ and Turvey SE and Subbarao P and Sears MR and Scott JA and Kozyrskyj AL and Canadian Healthy Infant Longitudinal Development (CHILD) Study Investigators
Combination therapy with proteasome inhibitors and TLR agonists enhances tumour cell death and IL-1ß production.
Cell death & disease
Tang AC and Rahavi SM and Fung SY and Lu HY and Yang H and Lim CJ and Reid GS and Turvey SE
Newborn screening for severe combined immunodeficiency: a primer for clinicians.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
Biggs CM and Haddad E and Issekutz TB and Roifman CM and Turvey SE
Associations between infant fungal and bacterial dysbiosis and childhood atopic wheeze in a nonindustrialized setting.
The Journal of allergy and clinical immunology
Arrieta MC and Arévalo A and Stiemsma L and Dimitriu P and Chico ME and Loor S and Vaca M and Boutin RCT and Morien E and Jin M and Turvey SE and Walter J and Parfrey LW and Cooper PJ and Finlay B
Parent-reported symptoms of sleep disordered breathing is associated with increased behavioral problems at 2 years of age: The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study.
Predicting the atopic march: Results from the Canadian Healthy Infant Longitudinal Development Study.
The Journal of allergy and clinical immunology
Does the impact of a plant-based diet during pregnancy on birth weight differ by ethnicity? A dietary pattern analysis from a prospective Canadian birth cohort alliance.
Patterns of allergic sensitization and atopic dermatitis from 1 to 3 years: effects on allergic diseases.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Trajectories of pain severity in juvenile idiopathic arthritis: results from the Research in Arthritis in Canadian Children Emphasizing Outcomes cohort.
Timing of food introduction and development of food sensitization in a prospective birth cohort.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Adiponectin, leptin and insulin in breast milk: associations with maternal characteristics and infant body composition in the first year of life.
International journal of obesity (2005)
Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
Journal of Visualized Experiments
Hong Yang and Shan Yu Fung and Aihua Bao and Qiang Li and Stuart E. Turvey
JAK1 gain-of-function causes an autosomal dominant immune dysregulatory and hypereosinophilic syndrome.
The Journal of allergy and clinical immunology
The importance of considering monogenic causes of autoimmunity: A somatic mutation in KRAS causing pediatric Rosai-Dorfman syndrome and systemic lupus erythematosus.
Clinical immunology (Orlando, Fla.)
Endoplasmic Reticulum Stress and Chemokine Production in Cystic Fibrosis Airway Cells: Regulation by STAT3 Modulation.
The Journal of infectious diseases
Canadian Society of Allergy and Clinical Immunology annual scientific meeting 2016.
Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
Fecal Short-Chain Fatty Acid Variations by Breastfeeding Status in Infants at 4¿Months: Differences in Relative versus Absolute Concentrations.
Frontiers in nutrition
Respiratory syncytial virus-neutralizing serum antibody titers in infants following palivizumab prophylaxis with an abbreviated dosing regimen.
Cesarean Section, Formula Feeding, and Infant Antibiotic Exposure: Separate and Combined Impacts on Gut Microbial Changes in Later Infancy.
Frontiers in pediatrics
Shifts in Lachnospira and Clostridium sp. in the 3-month stool microbiome are associated with preschool age asthma.
Clinical science (London, England : 1979)
Successful clinical treatment and functional immunological normalization of human MALT1 deficiency following hematopoietic stem cell transplantation.
Clinical immunology (Orlando, Fla.)
The risk and nature of flares in juvenile idiopathic arthritis: results from the ReACCh-Out cohort.
Guzman J and Oen K and Huber AM and Watanabe Duffy K and Boire G and Shiff N and Berard RA and Levy DM and Stringer E and Scuccimarri R and Morishita K and Johnson N and Cabral DA and Rosenberg AM and Larché M and Dancey P and Petty RE and Laxer RM and Silverman E and Miettunen P
Cognitive Enhancement in Infants Associated with Increased Maternal Fruit Intake During Pregnancy: Results from a Birth Cohort Study with Validation in an Animal Model.
A Family History of Psoriasis in a First-degree Relative in Children with JIA: to Include or Exclude?
Chan MO and Petty RE and Guzman J and ReACCh-Out Investigators
Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: a prospective cohort study.
BJOG : an international journal of obstetrics and gynaecology
Infant gut immunity: a preliminary study of IgA associations with breastfeeding.
Bridgman SL and Konya T and Azad MB and Sears MR and Becker AB and Turvey SE and Mandhane PJ and Subbarao P and CHILD Study Investigators and Scott JA and Field CJ and Kozyrskyj AL
Activity of SHIP, Which Prevents Expression of Interleukin 1ß, Is Reduced in Patients With Crohn's Disease.
Ngoh EN and Weisser SB and Lo Y and Kozicky LK and Jen R and Brugger HK and Menzies SC and McLarren KW and Nackiewicz D and van Rooijen N and Jacobson K and Ehses JA and Turvey SE and Sly LM
Outcomes of Respiratory Syncytial Virus Immunoprophylaxis in Infants Using an Abbreviated Dosing Regimen of Palivizumab.
Lavoie PM and Solimano A and Taylor R and Kwan E and Claydon J and Turvey SE and Marr N
IRAK-4 deficiency as a cause for familial fatal invasive infection by Streptococcus pneumoniae.
Grazioli S and Hamilton SJ and McKinnon ML and Del Bel KL and Hoang L and Cook VE and Hildebrand KJ and Junker AK and Turvey SE
AllerGen’s 8th research conference.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
Infant gut immunity: A preliminary study of IgA associations with breastfeeding
Journal of Developmental Origins of Health and Disease
A humanized microbiota mouse model of ovalbumin-induced lung inflammation
Proceedings of the Canadian society of allergy and clinical immunology annual scientific meeting 2015.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis.
Ombrello MJ and Remmers EF and Tachmazidou I and Grom A and Foell D and Haas JP and Martini A and Gattorno M and Özen S and Prahalad S and Zeft AS and Bohnsack JF and Mellins ED and Ilowite NT and Russo R and Len C and Hilario MO and Oliveira S and Yeung RS and Rosenberg A
The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-¿B signalling.
Klein T and Fung SY and Renner F and Blank MA and Dufour A and Kang S and Bolger-Munro M and Scurll JM and Priatel JJ and Schweigler P and Melkko S and Gold MR and Viner RI and Régnier CH and Turvey SE and Overall CM
The Crohn's disease-associated polymorphism in ATG16L1 (rs2241880) reduces SHIP gene expression and activity in human subjects.
Ngoh EN and Brugger HK and Monajemi M and Menzies SC and Hirschfeld AF and Del Bel KL and Jacobson K and Lavoie PM and Turvey SE and Sly LM
The outcomes of juvenile idiopathic arthritis in children managed with contemporary treatments: results from the ReACCh-Out cohort.
Guzman J and Oen K and Tucker LB and Huber AM and Shiff N and Boire G and Scuccimarri R and Berard R and Tse SM and Morishita K and Stringer E and Johnson N and Levy DM and Duffy KW and Cabral DA and Rosenberg AM and Larché M and Dancey P and Petty RE and Laxer RM
The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma.
Subbarao P and Anand SS and Becker AB and Befus AD and Brauer M and Brook JR and Denburg JA and HayGlass KT and Kobor MS and Kollmann TR and Kozyrskyj AL and Lou WY and Mandhane PJ and Miller GE and Moraes TJ and Pare PD and Scott JA and Takaro TK and Turvey SE and Duncan JM
Perinatal Exposure to Traffic-Related Air Pollution and Atopy at 1 Year of Age in a Multi-Center Canadian Birth Cohort Study.
Sbihi H and Allen RW and Becker A and Brook JR and Mandhane P and Scott JA and Sears MR and Subbarao P and Takaro TK and Turvey SE and Brauer M
Amino Acid-Dependent Attenuation of Toll-like Receptor Signaling by Peptide-Gold Nanoparticle Hybrids.
Yang H and Fung SY and Xu S and Sutherland DP and Kollmann TR and Liu M and Turvey SE
The Serine Protease Autotransporter Pic Modulates Citrobacter rodentium Pathogenesis and Its Innate Recognition by the Host.
Bhullar K and Zarepour M and Yu H and Yang H and Croxen M and Stahl M and Finlay BB and Turvey SE and Vallance BA
Infant gut microbiota and food sensitization: associations in the first year of life.
Azad MB and Konya T and Guttman DS and Field CJ and Sears MR and HayGlass KT and Mandhane PJ and Turvey SE and Subbarao P and Becker AB and Scott JA and Kozyrskyj AL and CHILD Study Investigators
The Canadian healthy infant longitudinal development birth cohort study: biological samples and biobanking.
Moraes TJ and Lefebvre DL and Chooniedass R and Becker AB and Brook JR and Denburg J and HayGlass KT and Hegele RG and Kollmann TR and Macri J and Mandhane PJ and Scott JA and Subbarao P and Takaro TK and Turvey SE and Duncan JD and Sears MR and Befus AD and CHILD Study Investigators
Impaired NLRP3 inflammasome activity during fetal development regulates IL-1ß production in human monocytes.
Sharma AA and Jen R and Kan B and Sharma A and Marchant E and Tang A and Gadawski I and Senger C and Skoll A and Turvey SE and Sly LM and Côté HC and Lavoie PM
The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study: assessment of environmental exposures.
Takaro TK and Scott JA and Allen RW and Anand SS and Becker AB and Befus AD and Brauer M and Duncan J and Lefebvre DL and Lou W and Mandhane PJ and McLean KE and Miller G and Sbihi H and Shu H and Subbarao P and Turvey SE and Wheeler AJ and Zeng L and Sears MR
Dual proteolytic pathways govern glycolysis and immune competence.
Lu W and Zhang Y and McDonald DO and Jing H and Carroll B and Robertson N and Zhang Q and Griffin H and Sanderson S and Lakey JH and Morgan NV and Reynard LN and Zheng L and Murdock HM and Turvey SE and Hackett SJ and Prestidge T and Hall JM and Cant AJ and Matthews HF
Current concepts: host-pathogen interactions in cystic fibrosis airways disease.
Tang AC and Turvey SE and Alves MP and Regamey N and Tümmler B and Hartl D
The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency.
Turvey SE and Durandy A and Fischer A and Fung SY and Geha RS and Gewies A and Giese T and Greil J and Keller B and McKinnon ML and Neven B and Rozmus J and Ruland J and Snow AL and Stepensky P and Warnatz K
A novel mouse model of Campylobacter jejuni gastroenteritis reveals key pro-inflammatory and tissue protective roles for Toll-like receptor signaling during infection.
Stahl M and Ries J and Vermeulen J and Yang H and Sham HP and Crowley SM and Badayeva Y and Turvey SE and Gaynor EC and Li X and Vallance BA
Limitation of TREC-based newborn screening for ZAP70 Severe Combined Immunodeficiency.
Grazioli S and Bennett M and Hildebrand KJ and Vallance H and Turvey SE and Junker AK
Combined immunodeficiency associated with homozygous MALT1 mutations.
McKinnon ML and Rozmus J and Fung SY and Hirschfeld AF and Del Bel KL and Thomas L and Marr N and Martin SD and Marwaha AK and Priatel JJ and Tan R and Senger C and Tsang A and Prendiville J and Junker AK and Seear M and Schultz KR and Sly LM and Holt RA and Patel MS
Attenuation of respiratory syncytial virus-induced and RIG-I-dependent type I IFN responses in human neonates and very young children.
Marr N and Wang TI and Kam SH and Hu YS and Sharma AA and Lam A and Markowski J and Solimano A and Lavoie PM and Turvey SE
Unbiased screening of marine sponge extracts for anti-inflammatory agents combined with chemical genomics identifies girolline as an inhibitor of protein synthesis.
Fung SY and Sofiyev V and Schneiderman J and Hirschfeld AF and Victor RE and Woods K and Piotrowski JS and Deshpande R and Li SC and de Voogd NJ and Myers CL and Boone C and Andersen RJ and Turvey SE
The early life gut microbiota and atopic disease.
Stiemsma LT and Arrieta M and Dimitriu PA and Thorson L and Yurist S and Brandt R and Lefebvre DL and Subbarao P and Mandhane P and Becker A and Sears M and Kollmann T and Mohn WW and Finlay BB and Turvey SE
Unbiased screening of marine sponge extracts for antiinflammatory agents combined with chemical genomics identifies girolline as an inhibitor of protein synthesis
ACS Chemical Biology
Optimizing pediatric venipuncture: ensuring successful blood sample collection with minimal stress and pain.
Mauro MA and Warner L and Mamonluk R and Turvey SE
Assessment of genetic associations between common single nucleotide polymorphisms in RIG-I-like receptor and IL-4 signaling genes and severe respiratory syncytial virus infection in children: a candidate gene case-control study.
Marr N and Hirschfeld AF and Lam A and Wang S and Lavoie PM and Turvey SE
Hierarchical maturation of innate immune defences in very preterm neonates.
Sharma AA and Jen R and Brant R and Ladd M and Huang Q and Skoll A and Senger C and Turvey SE and Marr N and Lavoie PM
Comparison of questionnaire responses with biomarkers of tobacco smoke exposure in a Canadian birth cohort at three months of age.
McLean K and Lanphear B and Wheeler AJ and Brook J and Scott J and Allen R and Brauer M and Sears M and Subbarao P and Turvey S and Becker A and Mandhane P and Takaro T
The impact of the intestinal microbiome on human immune development and atopic disease.
Thomas LT and Arrieta M and Dimitriu PA and Thorson L and Mohn WW and Finlay BB and Turvey SE
Optimizing subject retention in a longitudinal birth cohort study: lessons learned from the Vancouver site of the CHILD Study.
Warner L and Mauro MA and Menzies S and Assadian G and Mamonluk R and Lepine C and Turvey SE
Severe combined immunodeficiency (SCID) in Canadian children: a national surveillance study.
Rozmus J and Junker A and Thibodeau ML and Grenier D and Turvey SE and Yacoub W and Embree J and Haddad E and Langley JM and Ramsingh RM and Singh VA and Long R and Schultz KR
Pathogen recognition receptor crosstalk in respiratory syncytial virus sensing: a host and cell type perspective.
Marr N and Turvey SE and Grandvaux N
A new exposure metric for traffic-related air pollution? An analysis of determinants of hopanes in settled indoor house dust.
Sbihi H and Brook JR and Allen RW and Curran JH and Dell S and Mandhane P and Scott JA and Sears MR and Subbarao P and Takaro TK and Turvey SE and Wheeler AJ and Brauer M
Association of common single-nucleotide polymorphisms in innate immune genes with differences in TLR-induced cytokine production in neonates.
Cho P and Gelinas L and Corbett NP and Tebbutt SJ and Turvey SE and Fortuno ES and Kollmann TR
IL-4Ra on CD4+ T cells plays a pathogenic role in respiratory syncytial virus reinfection in mice infected initially as neonates.
You D and Marr N and Saravia J and Shrestha B and Lee GI and Turvey SE and Brombacher F and Herbert DR and Cormier SA
Functional genetic variation in NFKBIA and susceptibility to childhood asthma, bronchiolitis, and bronchopulmonary dysplasia.
Ali S and Hirschfeld AF and Mayer ML and Fortuno ES and Corbett N and Kaplan M and Wang S and Schneiderman J and Fjell CD and Yan J and Akhabir L and Aminuddin F and Marr N and Lacaze-Masmonteil T and Hegele RG and Becker A and Chan-Yeung M and Hancock RE and Kollmann TR and Daley D
Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months.
Azad MB and Konya T and Maughan H and Guttman DS and Field CJ and Chari RS and Sears MR and Becker AB and Scott JA and Kozyrskyj AL and CHILD Study Investigators
Rescue of dysfunctional autophagy attenuates hyperinflammatory responses from cystic fibrosis cells.
Mayer ML and Blohmke CJ and Falsafi R and Fjell CD and Madera L and Turvey SE and Hancock RE
Neonatal pain-related stress and NFKBIA genotype are associated with altered cortisol levels in preterm boys at school age.
Grunau RE and Cepeda IL and Chau CM and Brummelte S and Weinberg J and Lavoie PM and Ladd M and Hirschfeld AF and Russell E and Koren G and Van Uum S and Brant R and Turvey SE
Human primary immunodeficiencies causing defects in innate immunity
Current Opinion in Allergy and Clinical Immunology
A new exposure metric for traffic-related air pollution? An analysis of determinants of hopanes in settled indoor house dust
Environmental Health: A Global Access Science Source
Functional analysis of the impact of ORMDL3 expression on inflammation and activation of the unfolded protein response in human airway epithelial cells.
Hsu KJ and Turvey SE
Atypical activation of the unfolded protein response in cystic fibrosis airway cells contributes to p38 MAPK-mediated innate immune responses.
Blohmke CJ and Mayer ML and Tang AC and Hirschfeld AF and Fjell CD and Sze MA and Falsafi R and Wang S and Hsu K and Chilvers MA and Hogg JC and Hancock RE and Turvey SE
Successful approach to treatment of Helicobacter bilis infection in X-linked agammaglobulinemia.
Turvey SE and Leo SH and Boos A and Deans GD and Prendiville J and Crawford RI and Senger C and Conley ME and Tilley P and Junker A and Janz L and Azana R and Hoang L and Morton TL
Do adult disease severity subclassifications predict use of cyclophosphamide in children with ANCA-associated vasculitis? An analysis of ARChiVe study treatment decisions.
Morishita K and Guzman J and Chira P and Muscal E and Zeft A and Klein-Gitelman M and Uribe AG and Abramson L and Benseler SM and Eberhard A and Ede K and Hashkes PJ and Hersh AO and Higgins G and Imundo LF and Jung L and Kim S and Kingsbury DJ and Lawson EF and Lee T
Increased sensitivity of the European medicines agency algorithm for classification of childhood granulomatosis with polyangiitis.
The Journal of rheumatology
Assessing the performance of the Birmingham Vasculitis Activity Score at diagnosis for children with antineutrophil cytoplasmic antibody-associated vasculitis in A Registry for Childhood Vasculitis (ARChiVe).
Morishita K and Li SC and Muscal E and Spalding S and Guzman J and Uribe A and Abramson L and Baszis K and Benseler S and Bowyer S and Campillo S and Chira P and Hersh AO and Higgins G and Eberhard A and Ede K and Imundo L and Jung L and Kim S and Kingsbury DJ
Staphylococcus aureus nasal septal abscess complicated by extradural abscess in an infant.
Tan NW and Turvey SE and Byrne AT and Ludemann JP and Kollmann TR
Inflammasome-mediated IL-1ß production in humans with cystic fibrosis.
Tang A and Sharma A and Jen R and Hirschfeld AF and Chilvers MA and Lavoie PM and Turvey SE
Influence of common non-synonymous Toll-like receptor 4 polymorphisms on bronchopulmonary dysplasia and prematurity in human infants.
Lavoie PM and Ladd M and Hirschfeld AF and Huusko J and Mahlman M and Speert DP and Hallman M and Lacaze-Masmonteil T and Turvey SE
Variables to be controlled in the assessment of blood innate immune responses to Toll-like receptor stimulation.
Blimkie D and Fortuno ES and Yan H and Cho P and Ho K and Turvey SE and Marchant A and Goriely S and Kollmann TR
The Pseudomonas aeruginosa autoinducer 3O-C12 homoserine lactone provokes hyperinflammatory responses from cystic fibrosis airway epithelial cells.
Mayer ML and Sheridan JA and Blohmke CJ and Turvey SE and Hancock RE
Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients.
Gaglia JL and Guimaraes AR and Harisinghani M and Turvey SE and Jackson R and Benoist C and Mathis D and Weissleder R
Potential sources of phthalate exposure in a Vancouver birth cohort at three months of age
12th International Conference on Indoor Air Quality and Climate 2011
TLR5 as an anti-inflammatory target and modifier gene in cystic fibrosis.
Blohmke CJ and Park J and Hirschfeld AF and Victor RE and Schneiderman J and Stefanowicz D and Chilvers MA and Durie PR and Corey M and Zielenski J and Dorfman R and Sandford AJ and Daley D and Turvey SE
Ontogeny of Toll-like receptor mediated cytokine responses of human blood mononuclear cells.
Corbett NP and Blimkie D and Ho KC and Cai B and Sutherland DP and Kallos A and Crabtree J and Rein-Weston A and Lavoie PM and Turvey SE and Hawkins NR and Self SG and Wilson CB and Hajjar AM and Fortuno ES and Kollmann TR
TLR4 Asp299Gly and Thr399Ile polymorphisms: no impact on human immune responsiveness to LPS or respiratory syncytial virus.
Douville RN and Lissitsyn Y and Hirschfeld AF and Becker AB and Kozyrskyj AL and Liem J and Bastien N and Li Y and Victor RE and Sekhon M and Turvey SE and HayGlass KT
Serious musculoskeletal infections in children receiving anti-tumor necrosis factor-alpha therapy: a case series.
Morishita K and Petty R and Cairns R and Bolaria R and Cabral D and Turvey S
Acidification-dependent activation of CD1d-restricted natural killer T cells is intact in cystic fibrosis.
Rzemieniak SE and Hirschfeld AF and Victor RE and Chilvers MA and Zheng D and van den Elzen P and Turvey SE
Early outcomes and improvement of patients with juvenile idiopathic arthritis enrolled in a Canadian multicenter inception cohort.
Oen K and Duffy CM and Tse SM and Ramsey S and Ellsworth J and Chédeville G and Chetaille AL and Saint-Cyr C and Cabral DA and Spiegel LR and Schneider R and Lang B and Huber AM and Dancey P and Silverman E and Rosenberg AM and Cameron B and Johnson N and Dorval J and Scuccimarri R
Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome.
Woellner C and Gertz EM and Schäffer AA and Lagos M and Perro M and Glocker EO and Pietrogrande MC and Cossu F and Franco JL and Matamoros N and Pietrucha B and Heropolitanska-Pliszka E and Yeganeh M and Moin M and Español T and Ehl S and Gennery AR and Abinun M and Breborowicz A and Niehues T
Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity.
Brown KL and Falsafi R and Kum W and Hamill P and Gardy JL and Davidson DJ and Turvey S and Finlay BB and Speert DP and Hancock RE
Toll-like receptors 2 and 4 and the cryopyrin inflammasome in normal pregnancy and pre-eclampsia.
Xie F and Hu Y and Turvey SE and Magee LA and Brunham RM and Choi KC and Krajden M and Leung PC and Money DM and Patrick DM and Thomas E and von Dadelszen P
Functional characterization of human variants of NFKBIA: a key regulator of immune responsiveness implicated in susceptibility to infectious and inflammatory disease.
Ali S and Hirschfeld A and Victor R and Fortuno ES and Kollmann TR and Turvey SE
Toll-like receptor gene polymorphisms and preeclampsia risk: a case-control study and data synthesis.
Xie F and Hu Y and Speert DP and Turvey SE and Peng G and Money DM and Magee LA and von Dadelszen P and Toxaemia Study Group
Chlamydia pneumoniae infection in preeclampsia.
Xie F and Hu Y and Magee LA and Money DM and Patrick DM and Brunham RM and Thomas E and von Dadelszen P and Toxaemia group
Classification, presentation, and initial treatment of Wegener's granulomatosis in childhood.
Cabral DA and Uribe AG and Benseler S and O'Neil KM and Hashkes PJ and Higgins G and Zeft AS and Lovell DJ and Kingsbury DJ and Stevens A and McCurdy D and Chira P and Abramson L and Arkachaisri T and Campillo S and Eberhard A and Hersh AO and Huber AM and Kim S and Klein-Gitelman M
Potential Sources of Phthalate Exposure in a Vancouver, BC Birth Cohort at Three Months of Age
Tim Takaro and Ryan Allen and Roxanne Rouseau and Michael Brauer and James Scott and Jeff Brook and Stuart Turvey
Predictors of early inactive disease in a juvenile idiopathic arthritis cohort: results of a Canadian multicenter, prospective inception cohort study.
Oen K and Tucker L and Huber AM and Miettunen P and Scuccimarri R and Campillo S and Cabral DA and Feldman BM and Tse S and Chédeville G and Spiegel L and Schneider R and Lang B and Ellsworth J and Ramsey S and Dancey P and Silverman E and Chetaille AL and Cameron B and Johnson N
Relative CD4 lymphopenia and a skewed memory phenotype are the main immunologic abnormalities in a child with Omenn syndrome due to homozygous RAG1-C2633T hypomorphic mutation.
McCusker C and Hotte S and Le Deist F and Hirschfeld AF and Mitchell D and Nguyen VH and Gagnon R and Mazer B and Turvey SE and Jabado N
Optimizing outcomes of hematopoietic stem cell transplantation for severe combined immunodeficiency.
Cuvelier GD and Schultz KR and Davis J and Hirschfeld AF and Junker AK and Tan R and Turvey SE
Epidemiology of asthma: risk factors for development.
Subbarao P and Becker A and Brook JR and Daley D and Mandhane PJ and Miller GE and Turvey SE and Sears MR
Innate immunity mediated by TLR5 as a novel antiinflammatory target for cystic fibrosis lung disease.
Blohmke CJ and Victor RE and Hirschfeld AF and Elias IM and Hancock DG and Lane CR and Davidson AG and Wilcox PG and Smith KD and Overhage J and Hancock RE and Turvey SE
Commonly invasive serotypes of Streptococcus pneumoniae trigger a reduced innate immune response compared with serotypes rarely responsible for invasive infection.
Burgess TS and Hirschfeld AF and Tyrrell GJ and Bettinger JA and Turvey SE
Commonly invasive serotypes of Streptococcus pneumoniae trigger a reduced innate immune response compared with serotypes rarely responsible for invasive infection
FEMS Immunology and Medical Microbiology
Common human Toll-like receptor 4 polymorphisms--role in susceptibility to respiratory syncytial virus infection and functional immunological relevance.
Paulus SC and Hirschfeld AF and Victor RE and Brunstein J and Thomas E and Turvey SE
Prevalence of Toll-like receptor signalling defects in apparently healthy children who developed invasive pneumococcal infection.
Hirschfeld AF and Bettinger JA and Victor RE and Davidson DJ and Currie AJ and Ansermino JM and Scheifele DW and Orange JS and Turvey SE
Toll-like receptor 4 polymorphisms and idiopathic chromosomally normal miscarriage.
Hirschfeld AF and Jiang R and Robinson WP and McFadden DE and Turvey SE
IRAK-4 mutation (Q293X): rapid detection and characterization of defective post-transcriptional TLR/IL-1R responses in human myeloid and non-myeloid cells.
Davidson DJ and Currie AJ and Bowdish DM and Brown KL and Rosenberger CM and Ma RC and Bylund J and Campsall PA and Puel A and Picard C and Casanova JL and Turvey SE and Hancock RE and Devon RS and Speert DP
Detection of a novel nonsense mutation in the interleukin 2 receptor gamma gene causing X-linked severe combined immunodeficiency.
Cohen L and Hirschfeld AF and Junker AK and Davis J and Turvey SE
Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution.
Nishio J and Gaglia JL and Turvey SE and Campbell C and Benoist C and Mathis D
Questions and answers on immunization.
Paulus S and Turvey S
Old challenges and new directions in pediatric rheumatology.
Cabral DA and Laxer RM and Schrader J and Turvey S and Stevens A and Yeung RS and Foster HE and Emery H and Prendiville J and Tucker LB and Foeldvari I and Sherry DD and Klinkhoff AB and Wallace CA and Houghton K
Detection of a novel nonsense mutation in the interleukin 2 receptor ¿ gene causing X-linked severe combined immunodeficiency 
Annals of Allergy, Asthma and Immunology
Old challenges and new directions in pediatric rheumatology
Journal of Rheumatology
Questions and answers on immunization
Paediatrics and Child Health
Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes.
Turvey SE and Swart E and Denis MC and Mahmood U and Benoist C and Weissleder R and Mathis D
Primary immune deficiencies presenting in adults: seven years of experience from Iran.
Mansouri D and Adimi P and Mirsaedi M and Mansouri N and Tabarsi P and Amiri M and Jamaati HR and Motavasseli M and Baghaii N and Cheraghvandi A and Rouhi R and Roozbahany NA and Zahirifard S and Mohammadi F and Masjedi MR and Velayati AA and Casanova JL and Speert DP and Elwood RK and Schellenberg R
Adverse reactions to vitamin B12 injections due to benzyl alcohol sensitivity: successful treatment with intranasal cyanocobalamin.
Turvey SE and Cronin B and Arnold AD and Twarog FJ and Dioun AF
Rituximab therapy for multisystem autoimmune diseases in pediatric patients.
Binstadt BA and Caldas AM and Turvey SE and Stone KD and Weinstein HJ and Jackson J and Fuhlbrigge RC and Sundel RP
Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge.
MacGinnitie AJ and Walensky LD and Turvey SE and Orange JS and Bonilla FA and Silverman LB and Oettgen H
Churg-Strauss syndrome in a 7-year-old receiving montelukast and inhaled corticosteroids 
Annals of Allergy, Asthma and Immunology
IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo.
Hara M and Kingsley CI and Niimi M and Read S and Turvey SE and Bushell AR and Morris PJ and Powrie F and Wood KJ
Differential susceptibility of heart, skin, and islet allografts to T cell-mediated rejection.
Jones ND and Turvey SE and Van Maurik A and Hara M and Kingsley CI and Smith CH and Mellor AL and Morris PJ and Wood KJ
Islet allograft rejection can be mediated by CD4+, alloantigen experienced, direct pathway T cells of TH1 and TH2 cytokine phenotype.
Barbara JA and Turvey SE and Kingsley CI and Spriewald BM and Hara M and Witzke O and Morris PJ and Wood KJ
Fas ligand-transfected myoblasts and islet cell transplantation.
Turvey SE and Gonzalez-Nicolini V and Kingsley CI and Larregina AT and Morris PJ and Castro MG and Lowenstein PR and Wood KJ
Islet allograft rejection can be mediated by CD4+, alloantigen experienced, direct pathway T cells of Th1 and Th2 cytokine phenotype1
Fas ligand-transfected myoblasts and islet cell transplantation
Mechanisms of tolerance induction after intrathymic islet injection: determination of the fate of alloreactive thymocytes.
Turvey SE and Hara M and Morris PJ and Wood KJ
New insights on the mechanisms of acquired intrathymic tolerance
Current Opinion in Organ Transplantation
Stuart E. Turvey and Jeremy W. Fry and Kathryn J. Wood
Immunobiology of solid organ transplantation.
Turvey SE and Wood KJ
Mechanisms of tolerance induction after intrathymic islet injection: Determination of the fate of alloreactive thymocytes
Immunobiology of solid organ transplantation
Changes in myoplasmic sodium concentration during exposure to lactate in perfused rat heart.
Turvey SE and Allen DG
Intracellular calcium and myocardial function during ischemia.
Allen DG and Cairns SP and Turvey SE and Lee JA
Intracellular Calcium and Myocardial Function During Ischemia
Interactive Phenomena in the Cardiac System
David G. Allen and Simeon P. Cairns and Stuart E. Turvey and John A. Lee
Intracellular calcium and myocardial function during ischemia
Advances in Experimental Medicine and Biology
Harnessing the power of genomics to diagnose, treat and prevent pediatric immune disorders
Primary immunodeficiency diseases (PIDs) are a group of genetic disorders in which parts of the immune system are missing or dysfunctional. PIDs interfere with essential protective immune functions, greatly enhancing susceptibility to infections, autoimmunity, inflammation, and certain malignancies. The study of PIDs has played a critical role in expanding our understanding of the immune system and the development of treatment strategies that have applications far beyond PIDs. Despite our growing understanding of PIDs, many cases remain undiagnosed. My lab uses the power of genomics, including next-generation sequencing (NGS) technology, to discover the cause of novel PIDs, to accelerate diagnosis, to define target treatments, and to improve outcomes for children and their families.
Early-life origins of asthma and allergic disease
Asthma is a chronic inflammatory disease of the airways that typically begins in childhood. In Canada, more than 8% of people (~2.4 million in 2014) have been diagnosed with asthma. The underlying cause of asthma is a complex product of genetic and environmental factors; however research suggests that early life exposure to microbes alters immune system priming to increase susceptibility to asthma and allergic diseases. My lab aims to identify key compositional differences in the early-life gut microbiome, and metabolome between children who develop asthma and those who remain healthy, which can ultimately be targeted to predict and prevent asthma.
Canadian Healthy Infant Longitudinal Development (CHILD) Study
Over the past 30 years there has been an increasing concern about the effects of environment on health. In particular, since infants spend the majority of their time indoors, there is intense interest in the impact indoor pollution has on the health of our children. Our indoor environment has become a public health priority as growing evidence suggests that unseen environmental contaminants in our living spaces may have important effects on children's health and development.
The Canadian Healthy Infant Longitudinal Development (CHILD) Study is a multicentre, multidisciplinary, longitudinal, population-based birth-cohort study of -approximately 3,500 children enrolled "pre-birth" and followed until adolescence (www.childstudy.ca). The main purpose of this study is to determine what aspects of the environment interact with genetic factors to affect children’s health and development. I am a co-principal investigator for the CHILD study and I lead the Vancouver study site.Honours & Awards
Geoffrey L. Hammond Lectureship, 2018
Aubrey J. Tingle Professorship in Pediatric Immunology, 2012-Present
Canadian Society of Allergy and Clinical Immunology, Award for Research in Immunology 2013
Career Investigator Scholar Award, Michael Smith Foundation for Health Research, 2011-19.Research Group Members
Geraldine Blanchard, Visiting Clinician
Tamara Coffin, Clinical Research Assistant
Chelsea Cutler, Masters Student
Darlene Dai, Biostatistician
Kate Del Bel, Research Manager
Henry Lu, Graduate Trainee
Maureen Mooney, Clinical Research Nurse
Lauren Muttucomaroe, Research Assistant
Hind Sbihi, Postdoctoral Felllow
Mehul Sharma, Research Assistant
Valerie Tolsma, Administrative Assistant
Linda Warner, Clinical Research Coordinator
Tuesday and her parents, Sam Shoichet and Kristen Gagnon, are one of 3500 families taking part in the Canadian Healthy Infant Longitudinal Development (CHILD) study. Since the study launched in 2008, investigators have tracked the health, growth and environments of kids from birth to age five and made important discoveries about how asthma and allergies develop.