Overview

Despite much effort, we know little about how the healthy child is protected from infectious disease, and even less about why some children develop inflammatory disorders. Why do some healthy children succumb to overwhelming bacterial infection, while others either survive infection or do not become infected at all? Why do some children suffer crippling juvenile arthritis or life-threatening asthma?

My research program is translational, interdisciplinary and unique in its focus on understanding the role of innate immunity in infectious and inflammatory diseases of childhood. Starting with a population of children with a defined infectious or inflammatory disease phenotype (e.g., undue susceptibility to infection, juvenile idiopathic arthritis, asthma), I aim to determine the underlying cellular, molecular and genetic abnormalities responsible for the disease through detailed immunological, genomic and proteomic analysis. The new knowledge generated by this approach will aid diagnosis, elucidate mechanisms of disease pathogenesis and, ultimately, identify novel targets for anti-inflammatory and anti-infectious therapeutic agents.

Publications

The importance of functional validation after next-generation sequencing: evaluation of a novel CARD11 variant
Pediatric Allergy and Immunology
Henry Y. Lu and Mehul Sharma and Catherine M. Biggs and Yu-Hsuan Huang and Kevin E. Shopsowitz and Patrick Frosk and John J. Priatel and Tamar S. Rubin and Stuart E. Turvey
DOI: 10.1111/pai.12930
09/2018

Impact of maternal pre-pregnancy overweight on infant overweight at 1 year of age: associations and sex-specific differencesPrepregnancy obesity & infant overweight
Pediatric Obesity
S. L. Bridgman, M. B. Azad, R. R. Persaud, R. S. Chari, A. B. Becker, M. R. Sears, P. J. Mandhane, S. E. Turvey, P. Subbarao, A. M. Haqq, A. L. Kozyrskyj
DOI: 10.1111/ijpo.12291
05/2018

Exclusive breastfeeding in hospital predicts longer breastfeeding duration in Canada: Implications for health equity.
Birth (Berkeley, Calif.)
Vehling L, Chan D, McGavock J, Becker AB, Subbarao P, Moraes TJ, Mandhane PJ, Turvey SE, Lefebvre DL, Sears MR, Azad MB
DOI: 10.1111/birt.12345
PubMed: 29498088
03/2018

Roles of Birth Mode and Infant Gut Microbiota in Intergenerational Transmission of Overweight and Obesity From Mother to Offspring.
JAMA pediatrics
Tun HM, Bridgman SL, Chari R, Field CJ, Guttman DS, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Scott JA, Kozyrskyj AL, Canadian Healthy Infant Longitudinal Development (CHILD) Study Investigators
DOI: 10.1001/jamapediatrics.2017.5535
PubMed: 29459942
02/2018

Combination therapy with proteasome inhibitors and TLR agonists enhances tumour cell death and IL-1ß production.
Cell death & disease
Tang AC, Rahavi SM, Fung SY, Lu HY, Yang H, Lim CJ, Reid GS, Turvey SE
DOI: 10.1038/s41419-017-0194-1
PubMed: 29415982
02/2018

Newborn screening for severe combined immunodeficiency: a primer for clinicians.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
Biggs CM, Haddad E, Issekutz TB, Roifman CM, Turvey SE
DOI: 10.1503/cmaj.170561
PubMed: 29255099
12/2017

Predicting the atopic march: Results from the Canadian Healthy Infant Longitudinal Development Study.
The Journal of allergy and clinical immunology
DOI: 10.1016/j.jaci.2017.08.024
PubMed: 29153857
11/2017

Modes of Infant Feeding and the Risk of Childhood Asthma: A Prospective Birth Cohort Study.
The Journal of pediatrics
DOI: 10.1016/j.jpeds.2017.07.012
PubMed: 29144244
11/2017

Does the impact of a plant-based diet during pregnancy on birth weight differ by ethnicity? A dietary pattern analysis from a prospective Canadian birth cohort alliance.
BMJ open
DOI: 10.1136/bmjopen-2017-017753
PubMed: 29138203
11/2017

Patterns of allergic sensitization and atopic dermatitis from 1 to 3 years: effects on allergic diseases.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
DOI: 10.1111/cea.13063
PubMed: 29143385
11/2017

Parent-reported symptoms of sleep disordered breathing is associated with increased behavioral problems at 2 years of age: The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study.
Sleep
DOI: 10.1093/sleep/zsx177
PubMed: 29099980
11/2017

Associations between infant fungal and bacterial dysbiosis and childhood atopic wheeze in a nonindustrialized setting.
The Journal of allergy and clinical immunology
Arrieta MC, Arévalo A, Stiemsma L, Dimitriu P, Chico ME, Loor S, Vaca M, Boutin RCT, Morien E, Jin M, Turvey SE, Walter J, Parfrey LW, Cooper PJ, Finlay B
DOI: 10.1016/j.jaci.2017.08.041
PubMed: 29241587
11/2017

Sex-specific impact of asthma during pregnancy on infant gut microbiota.
The European respiratory journal
DOI: 10.1183/13993003.00280-2017
PubMed: 29167295
11/2017

Maternal depressive symptoms linked to reduced fecal Immunoglobulin A concentrations in infants.
Brain, behavior, and immunity
DOI: 10.1016/j.bbi.2017.10.007
PubMed: 29032226
10/2017

Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming.
Immunity
DOI: 10.1016/j.immuni.2017.09.003
PubMed: 29030115
10/2017

Trajectories of pain severity in juvenile idiopathic arthritis: results from the Research in Arthritis in Canadian Children Emphasizing Outcomes cohort.
Pain
DOI: 10.1097/j.pain.0000000000001064
PubMed: 28937578
09/2017

Growth and weight gain in children with juvenile idiopathic arthritis: results from the ReACCh-Out cohort.
Pediatric rheumatology online journal
DOI: 10.1186/s12969-017-0196-7
PubMed: 28830457
08/2017

Adiponectin, leptin and insulin in breast milk: associations with maternal characteristics and infant body composition in the first year of life.
International journal of obesity (2005)
DOI: 10.1038/ijo.2017.189
PubMed: 28925410
08/2017

Timing of food introduction and development of food sensitization in a prospective birth cohort.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
DOI: 10.1111/pai.12739
PubMed: 28557044
08/2017

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
Journal of Visualized Experiments
Hong Yang, Shan Yu Fung, Aihua Bao, Qiang Li, Stuart E. Turvey
DOI: 10.3791/56075
07/2017

Monogenic immune disorders and severe atopic disease
Nature Genetics
Catherine M Biggs, Henry Y Lu, Stuart E Turvey
DOI: 10.1038/ng.3925
07/2017

JAK1 gain-of-function causes an autosomal dominant immune dysregulatory and hypereosinophilic syndrome.
The Journal of allergy and clinical immunology
DOI: 10.1016/j.jaci.2016.12.957
PubMed: 28111307
06/2017

Breastfeeding, maternal asthma and wheezing in the first year of life: a longitudinal birth cohort study.
The European respiratory journal
DOI: 10.1183/13993003.02019-2016
PubMed: 28461293
05/2017

Exposure to household furry pets influences the gut microbiota of infant at 3-4 months following various birth scenarios.
Microbiome
DOI: 10.1186/s40168-017-0254-x
PubMed: 28381231
04/2017

Ethnic and diet-related differences in the healthy infant microbiome.
Genome medicine
DOI: 10.1186/s13073-017-0421-5
PubMed: 28356137
03/2017

The importance of considering monogenic causes of autoimmunity: A somatic mutation in KRAS causing pediatric Rosai-Dorfman syndrome and systemic lupus erythematosus.
Clinical immunology (Orlando, Fla.)
DOI: 10.1016/j.clim.2016.12.006
PubMed: 28043923
02/2017

Endoplasmic Reticulum Stress and Chemokine Production in Cystic Fibrosis Airway Cells: Regulation by STAT3 Modulation.
The Journal of infectious diseases
DOI: 10.1093/infdis/jiw516
PubMed: 27799352
01/2017

Pre-diagnostic genotyping identifies T1D subjects with impaired Treg IL-2 signaling and an elevated proportion of FOXP3+IL-17+ cells.
Genes and immunity
DOI: 10.1038/gene.2016.44
PubMed: 28053319
01/2017

Asthma and the microbiome: defining the critical window in early life
Allergy, Asthma & Clinical Immunology
Leah T. Stiemsma, Stuart E. Turvey
DOI: 10.1186/s13223-016-0173-6
01/2017

Canadian Society of Allergy and Clinical Immunology annual scientific meeting 2016.
Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
2017

Respiratory syncytial virus-neutralizing serum antibody titers in infants following palivizumab prophylaxis with an abbreviated dosing regimen.
PloS one
DOI: 10.1371/journal.pone.0176152
PubMed: 28437470
2017

In vivo immune signatures of healthy human pregnancy: Inherently inflammatory or anti-inflammatory?
PLoS ONE
DOI: 10.1371/journal.pone.0177813
PubMed: 28636613
2017

Cesarean Section, Formula Feeding, and Infant Antibiotic Exposure: Separate and Combined Impacts on Gut Microbial Changes in Later Infancy.
Frontiers in pediatrics
DOI: 10.3389/fped.2017.00200
PubMed: 29018787
2017

EVER1 and EVER2 Mutations in Epidermodysplasia Verruciformis
Encyclopedia of Medical Immunology
Robert J Ragotte, Stuart E Turvey
DOI: 10.1007/978-1-4614-9209-2_50-1
2017

Chronic Mucocutaneous Candidiasis, ACT1 Deficiency
Encyclopedia of Medical Immunology
Catherine M. Biggs, Stuart E. Turvey
DOI: 10.1007/978-1-4614-9209-2_63-1
2017

Fecal Short-Chain Fatty Acid Variations by Breastfeeding Status in Infants at 4¿Months: Differences in Relative versus Absolute Concentrations.
Frontiers in nutrition
DOI: 10.3389/fnut.2017.00011
PubMed: 28443284
2017

Shifts in Lachnospira and Clostridium sp. in the 3-month stool microbiome are associated with preschool age asthma.
Clinical science (London, England : 1979)
DOI: 10.1042/cs20160349
PubMed: 27634868
12/2016

Harmonization of Food-Frequency Questionnaires and Dietary Pattern Analysis in 4 Ethnically Diverse Birth Cohorts.
The Journal of nutrition
DOI: 10.3945/jn.116.236729
PubMed: 27708121
11/2016

Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function.
Journal of Clinical Investigation
DOI: 10.1172/jci89056
PubMed: 27721237
11/2016

Cystic Fibrosis: Modifier Genes
eLS
Aabida Saferali, Stuart E Turvey, Andrew J Sandford
DOI: 10.1002/9780470015902.a0020233
09/2016

High fecal IgA is associated with reduced Clostridium difficile colonization in infants.
Microbes and infection
DOI: 10.1016/j.micinf.2016.05.001
PubMed: 27235197
09/2016

Presence of Archaea in the Indoor Environment and Their Relationships with Housing Characteristics.
Microbial ecology
DOI: 10.1007/s00248-016-0767-z
PubMed: 27098176
08/2016

Association Between Artificially Sweetened Beverage Consumption During Pregnancy and Infant Body Mass Index.
JAMA pediatrics
DOI: 10.1001/jamapediatrics.2016.0301
PubMed: 27159792
07/2016

A humanized microbiota mouse model of ovalbumin-induced lung inflammation.
Gut microbes
DOI: 10.1080/19490976.2016.1182293
PubMed: 27115049
07/2016

Successful clinical treatment and functional immunological normalization of human MALT1 deficiency following hematopoietic stem cell transplantation.
Clinical immunology (Orlando, Fla.)
DOI: 10.1016/j.clim.2016.04.011
PubMed: 27109639
07/2016

The risk and nature of flares in juvenile idiopathic arthritis: results from the ReACCh-Out cohort.
Guzman J, Oen K, Huber AM, Watanabe Duffy K, Boire G, Shiff N, Berard RA, Levy DM, Stringer E, Scuccimarri R, Morishita K, Johnson N, Cabral DA, Rosenberg AM, Larché M, Dancey P, Petty RE, Laxer RM, Silverman E, Miettunen P
DOI: 10.1136/annrheumdis-2014-207164
PubMed: 25985972
06/2016

Cognitive Enhancement in Infants Associated with Increased Maternal Fruit Intake During Pregnancy: Results from a Birth Cohort Study with Validation in an Animal Model.
EBioMedicine
DOI: 10.1016/j.ebiom.2016.04.025
PubMed: 27428442
06/2016

Exome Sequencing and the Management of Neurometabolic Disorders.
The New England journal of medicine
DOI: 10.1056/nejmoa1515792
PubMed: 27276562
06/2016

A Family History of Psoriasis in a First-degree Relative in Children with JIA: to Include or Exclude?
Chan MO, Petty RE, Guzman J, ReACCh-Out Investigators
DOI: 10.3899/jrheum.150555
PubMed: 26980584
05/2016

Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: a prospective cohort study.
BJOG : an international journal of obstetrics and gynaecology
DOI: 10.1111/1471-0528.13601
PubMed: 26412384
05/2016

IRAK-4 deficiency as a cause for familial fatal invasive infection by Streptococcus pneumoniae.
Grazioli S, Hamilton SJ, McKinnon ML, Del Bel KL, Hoang L, Cook VE, Hildebrand KJ, Junker AK, Turvey SE
DOI: 10.1016/j.clim.2015.12.007
PubMed: 26698383
02/2016

Outcomes of Respiratory Syncytial Virus Immunoprophylaxis in Infants Using an Abbreviated Dosing Regimen of Palivizumab.
Lavoie PM, Solimano A, Taylor R, Kwan E, Claydon J, Turvey SE, Marr N
DOI: 10.1001/jamapediatrics.2015.3235
PubMed: 26720836
02/2016

Infant gut immunity: a preliminary study of IgA associations with breastfeeding.
Bridgman SL, Konya T, Azad MB, Sears MR, Becker AB, Turvey SE, Mandhane PJ, Subbarao P, CHILD Study Investigators, Scott JA, Field CJ, Kozyrskyj AL
DOI: 10.1017/s2040174415007862
PubMed: 26690933
02/2016

Activity of SHIP, Which Prevents Expression of Interleukin 1ß, Is Reduced in Patients With Crohn's Disease.
Ngoh EN, Weisser SB, Lo Y, Kozicky LK, Jen R, Brugger HK, Menzies SC, McLarren KW, Nackiewicz D, van Rooijen N, Jacobson K, Ehses JA, Turvey SE, Sly LM
DOI: 10.1053/j.gastro.2015.09.049
PubMed: 26481854
02/2016

A humanized microbiota mouse model of ovalbumin-induced lung inflammation
Gut microbes
Arrieta, M.-C. and Sadarangani, M. and Brown, E.M. and Russell, S.L. and Nimmo, M. and Dean, J. and Turvey, S.E. and Chan, E.S. and Finlay, B.B.
2016

Endosomal pH modulation by peptide-gold nanoparticle hybrids enables potent anti-inflammatory activity in phagocytic immune cells
Biomaterials
Yang, H. and Kozicky, L. and Saferali, A. and Fung, S.-Y. and Afacan, N. and Cai, B. and Falsafi, R. and Gill, E. and Liu, M. and Kollmann, T.R. and Hancock, R.E.W. and Sly, L.M. and Turvey, S.E.
DOI: 10.1016/j.biomaterials.2016.09.032
2016

Infant gut immunity: A preliminary study of IgA associations with breastfeeding
Journal of Developmental Origins of Health and Disease
Bridgman, S.L., Konya, T., Azad, M.B., Sears, M.R., Becker, A.B., Turvey, S.E., Mandhane, P.J., Subbarao, P., Sears, M.R., Subbarao, P., Allen, R., Anand, S.S., Becker, A.B., Befus, A.D., Brauer, M., Brook, J.R., Chen, E., Cyr, M., Daley, D., Dell, S., Denburg, J.A., Elliott, S., Grasemann, H., HayGlass, K., Hegele, R., Holness, D.L., Lou, W.Y.W., Kobor, M.S., Kollman, T.R., Kozyrskyj, A.L., Laprise, C., Larché, M., MacRi, J., Mandhane, P.M., Miller, G., Moqbel, R., Moraes, T., Paré, P.D., Ramsey, C., Ratjen, F., Sandford, A., Scott, J.A., Scott, J., Silverman, F., Takaro, T., Tang, P., Tebbutt, S., To, T., Scott, J.A., Field, C.J., Kozyrskyj, A.L.
DOI: 10.1017/S2040174415007862
2016

Exome sequencing and the management of neurometabolic disorders
New England Journal of Medicine
Tarailo-Graovac, M., Shyr, C., Ross, C.J., Horvath, G.A., Salvarinova, R., Ye, X.C., Zhang, L.-H., Bhavsar, A.P., Lee, J.J.Y., Drögemöller, B.I., Abdelsayed, M., Alfadhel, M., Armstrong, L., Baumgartner, M.R., Burda, P., Connolly, M.B., Cameron, J., Demos, M., Dewan, T., Dionne, J., Evans, A.M., Friedman, J.M., Garber, I., Lewis, S., Ling, J., Mandal, R., Mattman, A., McKinnon, M., Michoulas, A., Metzger, D., Ogunbayo, O.A., Rakic, B., Rozmus, J., Ruben, P., Sayson, B., Santra, S., Schultz, K.R., Selby, K., Shekel, P., Sirrs, S., Skrypnyk, C., Superti-Furga, A., Turvey, S.E., Van Allen, M.I., Wishart, D., Wu, J., Wu, J., Zafeiriou, D., Kluijtmans, L., Wevers, R.A., Eydoux, P., Lehman, A.M., Vallance, H., Stockler-Ipsiroglu, S., Sinclair, G., Wasserman, W.W., Van Karnebeek, C.D.
DOI: 10.1056/NEJMoa1515792
2016

Proceedings of the Canadian society of allergy and clinical immunology annual scientific meeting 2015.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
2016

AllerGen’s 8th research conference.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
2016

Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function
Journal of Clinical Investigation
Concepcion, A.R. and Vaeth, M. and Wagner, L.E. and Eckstein, M. and Hecht, L. and Jun, Y. and Crottes, D. and Seidl, M. and Shin, H.P. and Weidinger, C. and Cameron, S. and Turvey, S.E. and Issekutz, T. and Meyts, I. and Lacruz, R.S. and Cuk, M. and Yule, D.I. and Feske, S.
DOI: 10.1172/JCI89056
2016

Shifts in Lachnospira and Clostridium sp. in the 3-month stool microbiome are associated with preschool age asthma
Clinical Science
Stiemsma, L.T. and Arrieta, M.-C. and Dimitriu, P.A. and Cheng, J. and Thorson, L. and Lefebvre, D.L. and Azad, M.B. and Subbarao, P. and Mandhane, P. and Becker, A. and Sears, M.R. and Kollmann, T.R. and Mohn, W.W. and Finlay, B.B. and Turvey, S.E.
DOI: 10.1042/CS20160349
2016

Gene expression deconvolution for uncovering molecular signatures in response to therapy in juvenile idiopathic arthritis
PLoS ONE
Cui, A., Quon, G., Rosenberg, A.M., Yeung, R.S.M., Morris, Q., Dancey, P., Huber, A., Lang, B., Ramsey, S., Stringer, E., Chetaille, A.-L., Boire, G., Campillo, S., Ch�deville, G., Scuccimarri, R., Duffy, C., Duffy, K.W., Gibbon, M., Jurencak, R., Roth, J., Benseler, S., Cameron, B., Feldman, B., Laxer, R., Schneider, R., Spiegel, L., Tse, S., Oen, K., Rezaei, E., Matheson, L., Ellsworth, J., Cabral, D.A., Guzman, J., Houghton, K., Petty, R., Tucker, L.B., Turvey, S.
DOI: 10.1371/journal.pone.0156055
2016

HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis.
Ombrello MJ, Remmers EF, Tachmazidou I, Grom A, Foell D, Haas JP, Martini A, Gattorno M, Özen S, Prahalad S, Zeft AS, Bohnsack JF, Mellins ED, Ilowite NT, Russo R, Len C, Hilario MO, Oliveira S, Yeung RS, Rosenberg A
DOI: 10.1073/pnas.1520779112
PubMed: 26598658
12/2015

The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-¿B signalling.
Klein T, Fung SY, Renner F, Blank MA, Dufour A, Kang S, Bolger-Munro M, Scurll JM, Priatel JJ, Schweigler P, Melkko S, Gold MR, Viner RI, Régnier CH, Turvey SE, Overall CM
DOI: 10.1038/ncomms9777
PubMed: 26525107
11/2015

The Crohn's disease-associated polymorphism in ATG16L1 (rs2241880) reduces SHIP gene expression and activity in human subjects.
Ngoh EN, Brugger HK, Monajemi M, Menzies SC, Hirschfeld AF, Del Bel KL, Jacobson K, Lavoie PM, Turvey SE, Sly LM
DOI: 10.1038/gene.2015.30
PubMed: 26226011
10/2015

The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma.
Subbarao P, Anand SS, Becker AB, Befus AD, Brauer M, Brook JR, Denburg JA, HayGlass KT, Kobor MS, Kollmann TR, Kozyrskyj AL, Lou WY, Mandhane PJ, Miller GE, Moraes TJ, Pare PD, Scott JA, Takaro TK, Turvey SE, Duncan JM
DOI: 10.1136/thoraxjnl-2015-207246
PubMed: 26069286
10/2015

The outcomes of juvenile idiopathic arthritis in children managed with contemporary treatments: results from the ReACCh-Out cohort.
Guzman J, Oen K, Tucker LB, Huber AM, Shiff N, Boire G, Scuccimarri R, Berard R, Tse SM, Morishita K, Stringer E, Johnson N, Levy DM, Duffy KW, Cabral DA, Rosenberg AM, Larché M, Dancey P, Petty RE, Laxer RM
DOI: 10.1136/annrheumdis-2014-205372
PubMed: 24842571
10/2015

Early infancy microbial and metabolic alterations affect risk of childhood asthma.
Science translational medicine
DOI: 10.1126/scitranslmed.aab2271
PubMed: 26424567
09/2015

Perinatal Exposure to Traffic-Related Air Pollution and Atopy at 1 Year of Age in a Multi-Center Canadian Birth Cohort Study.
Sbihi H, Allen RW, Becker A, Brook JR, Mandhane P, Scott JA, Sears MR, Subbarao P, Takaro TK, Turvey SE, Brauer M
DOI: 10.1289/ehp.1408700
PubMed: 25826816
09/2015

The Serine Protease Autotransporter Pic Modulates Citrobacter rodentium Pathogenesis and Its Innate Recognition by the Host.
Bhullar K, Zarepour M, Yu H, Yang H, Croxen M, Stahl M, Finlay BB, Turvey SE, Vallance BA
DOI: 10.1128/iai.00025-15
PubMed: 25895966
07/2015

Amino Acid-Dependent Attenuation of Toll-like Receptor Signaling by Peptide-Gold Nanoparticle Hybrids.
Yang H, Fung SY, Xu S, Sutherland DP, Kollmann TR, Liu M, Turvey SE
DOI: 10.1021/nn505634h
PubMed: 26083966
07/2015

Infant gut microbiota and food sensitization: associations in the first year of life.
Azad MB, Konya T, Guttman DS, Field CJ, Sears MR, HayGlass KT, Mandhane PJ, Turvey SE, Subbarao P, Becker AB, Scott JA, Kozyrskyj AL, CHILD Study Investigators
DOI: 10.1111/cea.12487
PubMed: 25599982
03/2015

Impaired NLRP3 inflammasome activity during fetal development regulates IL-1ß production in human monocytes.
Sharma AA, Jen R, Kan B, Sharma A, Marchant E, Tang A, Gadawski I, Senger C, Skoll A, Turvey SE, Sly LM, Côté HC, Lavoie PM
DOI: 10.1002/eji.201444707
PubMed: 25311115
01/2015

The Canadian healthy infant longitudinal development birth cohort study: biological samples and biobanking.
Moraes TJ, Lefebvre DL, Chooniedass R, Becker AB, Brook JR, Denburg J, HayGlass KT, Hegele RG, Kollmann TR, Macri J, Mandhane PJ, Scott JA, Subbarao P, Takaro TK, Turvey SE, Duncan JD, Sears MR, Befus AD, CHILD Study Investigators
DOI: 10.1111/ppe.12161
PubMed: 25405552
01/2015

Perinatal exposure to traffic-related air pollution and atopy at 1 year of age in a multi-center Canadian birth cohort study
Environmental Health Perspectives
Sbihi, H. and Allen, R.W. and Becker, A. and Brook, J.R. and Mandhane, P. and Scott, J.A. and Sears, M.R. and Subbarao, P. and Takaro, T.K. and Turvey, S.E. and Brauer, M.
DOI: 10.1289/ehp.1408700.
2015

The serine protease autotransporter Pic modulates Citrobacter rodentium pathogenesis and its innate recognition by the host
Infection and Immunity
Bhullar, K. and Zarepour, M. and Yu, H. and Yang, H. and Croxen, M. and Stahl, M. and Finlay, B.B. and Turvey, S.E. and Vallance, B.A.
DOI: 10.1128/IAI.00025-15
2015

The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study: assessment of environmental exposures.
Takaro TK, Scott JA, Allen RW, Anand SS, Becker AB, Befus AD, Brauer M, Duncan J, Lefebvre DL, Lou W, Mandhane PJ, McLean KE, Miller G, Sbihi H, Shu H, Subbarao P, Turvey SE, Wheeler AJ, Zeng L, Sears MR
DOI: 10.1038/jes.2015.7
PubMed: 25805254
2015

The hygiene hypothesis: current perspectives and future therapies.
Stiemsma LT, Reynolds LA, Turvey SE, Finlay BB
DOI: 10.2147/itt.s61528
PubMed: 27471720
2015

Dual proteolytic pathways govern glycolysis and immune competence.
Lu W, Zhang Y, McDonald DO, Jing H, Carroll B, Robertson N, Zhang Q, Griffin H, Sanderson S, Lakey JH, Morgan NV, Reynard LN, Zheng L, Murdock HM, Turvey SE, Hackett SJ, Prestidge T, Hall JM, Cant AJ, Matthews HF
DOI: 10.1016/j.cell.2014.12.001
PubMed: 25525876
12/2014

Current concepts: host-pathogen interactions in cystic fibrosis airways disease.
Tang AC, Turvey SE, Alves MP, Regamey N, Tümmler B, Hartl D
DOI: 10.1183/09059180.00006113
PubMed: 25176968
09/2014

The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency.
Turvey SE, Durandy A, Fischer A, Fung SY, Geha RS, Gewies A, Giese T, Greil J, Keller B, McKinnon ML, Neven B, Rozmus J, Ruland J, Snow AL, Stepensky P, Warnatz K
DOI: 10.1016/j.jaci.2014.06.015
PubMed: 25087226
08/2014

Limitation of TREC-based newborn screening for ZAP70 Severe Combined Immunodeficiency.
Grazioli S, Bennett M, Hildebrand KJ, Vallance H, Turvey SE, Junker AK
DOI: 10.1016/j.clim.2014.04.015
PubMed: 24797280
07/2014

A novel mouse model of Campylobacter jejuni gastroenteritis reveals key pro-inflammatory and tissue protective roles for Toll-like receptor signaling during infection.
Stahl M, Ries J, Vermeulen J, Yang H, Sham HP, Crowley SM, Badayeva Y, Turvey SE, Gaynor EC, Li X, Vallance BA
DOI: 10.1371/journal.ppat.1004264
PubMed: 25033044
07/2014

Combined immunodeficiency associated with homozygous MALT1 mutations.
McKinnon ML, Rozmus J, Fung SY, Hirschfeld AF, Del Bel KL, Thomas L, Marr N, Martin SD, Marwaha AK, Priatel JJ, Tan R, Senger C, Tsang A, Prendiville J, Junker AK, Seear M, Schultz KR, Sly LM, Holt RA, Patel MS
DOI: 10.1016/j.jaci.2013.10.045
PubMed: 24332264
05/2014

Associations between bacterial communities of house dust and infant gut.
Environmental research
DOI: 10.1016/j.envres.2014.02.005
PubMed: 24637181
05/2014

Attenuation of respiratory syncytial virus-induced and RIG-I-dependent type I IFN responses in human neonates and very young children.
Marr N, Wang TI, Kam SH, Hu YS, Sharma AA, Lam A, Markowski J, Solimano A, Lavoie PM, Turvey SE
DOI: 10.4049/jimmunol.1302007
PubMed: 24391215
02/2014

An antibiotic-altered microbiota provides fuel for the enteric foe.
Stiemsma LT, Turvey SE, Finlay BB
DOI: 10.1038/cr.2013.142
PubMed: 24165893
01/2014

Unbiased screening of marine sponge extracts for anti-inflammatory agents combined with chemical genomics identifies girolline as an inhibitor of protein synthesis.
Fung SY, Sofiyev V, Schneiderman J, Hirschfeld AF, Victor RE, Woods K, Piotrowski JS, Deshpande R, Li SC, de Voogd NJ, Myers CL, Boone C, Andersen RJ, Turvey SE
DOI: 10.1021/cb400740c
PubMed: 24117378
01/2014

Assessment of genetic associations between common single nucleotide polymorphisms in RIG-I-like receptor and IL-4 signaling genes and severe respiratory syncytial virus infection in children: a candidate gene case-control study.
Marr N, Hirschfeld AF, Lam A, Wang S, Lavoie PM, Turvey SE
DOI: 10.1371/journal.pone.0100269
PubMed: 24949794
2014

The early life gut microbiota and atopic disease
Allergy, Asthma and Clinical Immunology
Stiemsma, L.T. and Arrieta, M.-C. and Dimitriu, P.A. and Thorson, L. and Yurist, S. and Brandt, R. and Lefebvre, D.L. and Subbarao, P. and Mandhane, P. and Becker, A. and Sears, M. and Kollmann, T. and Mohn, W.W. and Finlay, B.B. and Turvey, S.E. and the CHILD Study Investigators
DOI: 10.1186/1710-1492-10-S2-A63
2014

Hierarchical maturation of innate immune defences in very preterm neonates.
Sharma AA, Jen R, Brant R, Ladd M, Huang Q, Skoll A, Senger C, Turvey SE, Marr N, Lavoie PM
DOI: 10.1159/000358550
PubMed: 24603545
2014

Comparison of questionnaire responses with biomarkers of tobacco smoke exposure in a Canadian birth cohort at three months of age.
McLean K, Lanphear B, Wheeler AJ, Brook J, Scott J, Allen R, Brauer M, Sears M, Subbarao P, Turvey S, Becker A, Mandhane P, Takaro T
DOI: 10.1186/1710-1492-10-s1-a60
2014

Optimizing pediatric venipuncture: ensuring successful blood sample collection with minimal stress and pain.
Mauro MA, Warner L, Mamonluk R, Turvey SE
DOI: 10.1186/1710-1492-10-s2-a59
2014

Optimizing subject retention in a longitudinal birth cohort study: lessons learned from the Vancouver site of the CHILD Study.
Warner L, Mauro MA, Menzies S, Assadian G, Mamonluk R, Lepine C, Turvey SE
DOI: 10.1186/1710-1492-10-s1-a20
2014

Optimizing pediatric venipuncture: Ensuring successful blood sample collection with minimal stress and pain
Allergy, Asthma and Clinical Immunology
Mauro, M.A. and Warner, L. and Mamonluk, R. and Turvey, S.E.
DOI: 10.1186/1710-1492-10-S2-A59
2014

Unbiased screening of marine sponge extracts for antiinflammatory agents combined with chemical genomics identifies girolline as an inhibitor of protein synthesis
ACS Chemical Biology
Fung, S.-Y. and Sofiyev, V. and Schneiderman, J. and Hirschfeld, A.F. and Victor, R.E. and Woods, K. and Piotrowski, J.S. and Deshpande, R. and Li, S.C. and De Voogd, N.J. and Myers, C.L. and Boone, C. and Andersen, R.J. and Turvey, S.E.
DOI: 10.1021/cb400740
2014

The early life gut microbiota and atopic disease.
Stiemsma LT, Arrieta M, Dimitriu PA, Thorson L, Yurist S, Brandt R, Lefebvre DL, Subbarao P, Mandhane P, Becker A, Sears M, Kollmann T, Mohn WW, Finlay BB, Turvey SE
DOI: 10.1186/1710-1492-10-s2-a63
2014

The impact of the intestinal microbiome on human immune development and atopic disease.
Thomas LT, Arrieta M, Dimitriu PA, Thorson L, Mohn WW, Finlay BB, Turvey SE
DOI: 10.1186/1710-1492-10-s1-a63
2014

Human primary immunodeficiencies causing defects in innate immunity.
Wong T, Yeung J, Hildebrand KJ, Junker AK, Turvey SE
DOI: 10.1097/aci.0000000000000010
PubMed: 24126612
12/2013

Severe combined immunodeficiency (SCID) in Canadian children: a national surveillance study.
Rozmus J, Junker A, Thibodeau ML, Grenier D, Turvey SE, Yacoub W, Embree J, Haddad E, Langley JM, Ramsingh RM, Singh VA, Long R, Schultz KR
DOI: 10.1007/s10875-013-9952-8
PubMed: 24122030
11/2013

Pathogen recognition receptor crosstalk in respiratory syncytial virus sensing: a host and cell type perspective.
Marr N, Turvey SE, Grandvaux N
DOI: 10.1016/j.tim.2013.08.006
PubMed: 24119913
11/2013

Innate Immunity
Primary Immunodeficiency Diseases
Jordan S. Orange, Michael M. Frank, Stuart E. Turvey
DOI: 10.1093/med/9780195389838.003.0008
11/2013

IL-4Ra on CD4+ T cells plays a pathogenic role in respiratory syncytial virus reinfection in mice infected initially as neonates.
You D, Marr N, Saravia J, Shrestha B, Lee GI, Turvey SE, Brombacher F, Herbert DR, Cormier SA
DOI: 10.1189/jlb.1012498
PubMed: 23543769
06/2013

A new exposure metric for traffic-related air pollution? An analysis of determinants of hopanes in settled indoor house dust.
Sbihi H, Brook JR, Allen RW, Curran JH, Dell S, Mandhane P, Scott JA, Sears MR, Subbarao P, Takaro TK, Turvey SE, Wheeler AJ, Brauer M
DOI: 10.1186/1476-069x-12-48
PubMed: 23782977
06/2013

Association of common single-nucleotide polymorphisms in innate immune genes with differences in TLR-induced cytokine production in neonates.
Cho P, Gelinas L, Corbett NP, Tebbutt SJ, Turvey SE, Fortuno ES, Kollmann TR
DOI: 10.1038/gene.2013.5
PubMed: 23466493
06/2013

Functional genetic variation in NFKBIA and susceptibility to childhood asthma, bronchiolitis, and bronchopulmonary dysplasia.
Ali S, Hirschfeld AF, Mayer ML, Fortuno ES, Corbett N, Kaplan M, Wang S, Schneiderman J, Fjell CD, Yan J, Akhabir L, Aminuddin F, Marr N, Lacaze-Masmonteil T, Hegele RG, Becker A, Chan-Yeung M, Hancock RE, Kollmann TR, Daley D
DOI: 10.4049/jimmunol.1201015
PubMed: 23487427
04/2013

Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months.
Azad MB, Konya T, Maughan H, Guttman DS, Field CJ, Chari RS, Sears MR, Becker AB, Scott JA, Kozyrskyj AL, CHILD Study Investigators
DOI: 10.1503/cmaj.121189
PubMed: 23401405
03/2013

Rescue of dysfunctional autophagy attenuates hyperinflammatory responses from cystic fibrosis cells.
Mayer ML, Blohmke CJ, Falsafi R, Fjell CD, Madera L, Turvey SE, Hancock RE
DOI: 10.4049/jimmunol.1201404
PubMed: 23264659
02/2013

Functional analysis of the impact of ORMDL3 expression on inflammation and activation of the unfolded protein response in human airway epithelial cells.
Hsu KJ, Turvey SE
DOI: 10.1186/1710-1492-9-4
PubMed: 23369242
2013

Amino acid structure determines the immune responses generated by peptide-gold nanoparticle hybrids
Particle and Particle Systems Characterization
Yang, H. and Zhou, Y. and Fung, S.-Y. and Wu, L. and Tsai, K. and Tan, R. and Turvey, S.E. and Machuca, T. and De Perrot, M. and Waddell, T.K. and Liu, M.
DOI: 10.1002/ppsc.201300213
2013

A new exposure metric for traffic-related air pollution? An analysis of determinants of hopanes in settled indoor house dust
Environmental Health: A Global Access Science Source
Sbihi, H. and Brook, J.R. and Allen, R.W. and Curran, J.H. and Dell, S. and Mandhane, P. and Scott, J.A. and Sears, M.R. and Subbarao, P. and Takaro, T.K. and Turvey, S.E. and Wheeler, A.J. and Brauer, M.
DOI: 10.1186/1476-069X-12-48
2013

Human primary immunodeficiencies causing defects in innate immunity
Current Opinion in Allergy and Clinical Immunology
Wong, T. and Yeung, J. and Hildebrand, K.J. and Junker, A.K. and Turvey, S.E.
DOI: 10.1097/ACI.0000000000000010
2013

Neonatal pain-related stress and NFKBIA genotype are associated with altered cortisol levels in preterm boys at school age.
Grunau RE, Cepeda IL, Chau CM, Brummelte S, Weinberg J, Lavoie PM, Ladd M, Hirschfeld AF, Russell E, Koren G, Van Uum S, Brant R, Turvey SE
DOI: 10.1371/journal.pone.0073926
PubMed: 24066085
2013

Successful approach to treatment of Helicobacter bilis infection in X-linked agammaglobulinemia.
Turvey SE, Leo SH, Boos A, Deans GD, Prendiville J, Crawford RI, Senger C, Conley ME, Tilley P, Junker A, Janz L, Azana R, Hoang L, Morton TL
DOI: 10.1007/s10875-012-9750-8
PubMed: 22843217
12/2012

Role of human TLR4 in respiratory syncytial virus-induced NF-¿B activation, viral entry and replication.
Marr N, Turvey SE
DOI: 10.1177/1753425912444479
PubMed: 22535679
12/2012

Atypical activation of the unfolded protein response in cystic fibrosis airway cells contributes to p38 MAPK-mediated innate immune responses.
Blohmke CJ, Mayer ML, Tang AC, Hirschfeld AF, Fjell CD, Sze MA, Falsafi R, Wang S, Hsu K, Chilvers MA, Hogg JC, Hancock RE, Turvey SE
DOI: 10.4049/jimmunol.1103661
PubMed: 23105139
12/2012

Do adult disease severity subclassifications predict use of cyclophosphamide in children with ANCA-associated vasculitis? An analysis of ARChiVe study treatment decisions.
Morishita K, Guzman J, Chira P, Muscal E, Zeft A, Klein-Gitelman M, Uribe AG, Abramson L, Benseler SM, Eberhard A, Ede K, Hashkes PJ, Hersh AO, Higgins G, Imundo LF, Jung L, Kim S, Kingsbury DJ, Lawson EF, Lee T
DOI: 10.3899/jrheum.120299
PubMed: 22859342
10/2012

Increased sensitivity of the European medicines agency algorithm for classification of childhood granulomatosis with polyangiitis.
The Journal of rheumatology
DOI: 10.3899/jrheum.111352
PubMed: 22589257
08/2012

Assessing the performance of the Birmingham Vasculitis Activity Score at diagnosis for children with antineutrophil cytoplasmic antibody-associated vasculitis in A Registry for Childhood Vasculitis (ARChiVe).
Morishita K, Li SC, Muscal E, Spalding S, Guzman J, Uribe A, Abramson L, Baszis K, Benseler S, Bowyer S, Campillo S, Chira P, Hersh AO, Higgins G, Eberhard A, Ede K, Imundo L, Jung L, Kim S, Kingsbury DJ
DOI: 10.3899/jrheum.111030
PubMed: 22337238
05/2012

Staphylococcus aureus nasal septal abscess complicated by extradural abscess in an infant.
Tan NW, Turvey SE, Byrne AT, Ludemann JP, Kollmann TR
PubMed: 22498276
02/2012

Inflammasome-mediated IL-1ß production in humans with cystic fibrosis.
Tang A, Sharma A, Jen R, Hirschfeld AF, Chilvers MA, Lavoie PM, Turvey SE
DOI: 10.1371/journal.pone.0037689
PubMed: 22649552
2012

Influence of common non-synonymous Toll-like receptor 4 polymorphisms on bronchopulmonary dysplasia and prematurity in human infants.
Lavoie PM, Ladd M, Hirschfeld AF, Huusko J, Mahlman M, Speert DP, Hallman M, Lacaze-Masmonteil T, Turvey SE
DOI: 10.1371/journal.pone.0031351
PubMed: 22348075
2012

Staphylococcus aureus nasal septal abscess complicated by extradural abscess in an infant
Journal of Otolaryngology - Head and Neck Surgery
Tan, N.W.H. and Turvey, S.E. and Byrne, A.T. and Ludemann, J.P. and Kollmann, T.R.
DOI: 10.2310/7070.2011.110136
2012

Variables to be controlled in the assessment of blood innate immune responses to Toll-like receptor stimulation.
Blimkie D, Fortuno ES, Yan H, Cho P, Ho K, Turvey SE, Marchant A, Goriely S, Kollmann TR
DOI: 10.1016/j.jim.2011.01.009
PubMed: 21277305
03/2011

The Pseudomonas aeruginosa autoinducer 3O-C12 homoserine lactone provokes hyperinflammatory responses from cystic fibrosis airway epithelial cells.
Mayer ML, Sheridan JA, Blohmke CJ, Turvey SE, Hancock RE
DOI: 10.1371/journal.pone.0016246
PubMed: 21305014
01/2011

Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients.
Gaglia JL, Guimaraes AR, Harisinghani M, Turvey SE, Jackson R, Benoist C, Mathis D, Weissleder R
DOI: 10.1172/jci44339
PubMed: 21123946
01/2011

Potential sources of phthalate exposure in a Vancouver birth cohort at three months of age
12th International Conference on Indoor Air Quality and Climate 2011
Shu, H. and Allen, R. and Brauer, M. and Rousseau, R. and Takaro, T. and Turvey, S.
2011

Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients
Journal of Clinical Investigation
Gaglia, J.L. and Guimaraes, A.R. and Harisinghani, M. and Turvey, S.E. and Jackson, R. and Benoist, C. and Mathis, D. and Weissleder, R.
DOI: 10.1172/JCI44339
2011

TLR5 as an anti-inflammatory target and modifier gene in cystic fibrosis.
Blohmke CJ, Park J, Hirschfeld AF, Victor RE, Schneiderman J, Stefanowicz D, Chilvers MA, Durie PR, Corey M, Zielenski J, Dorfman R, Sandford AJ, Daley D, Turvey SE
DOI: 10.4049/jimmunol.1001513
PubMed: 21068401
12/2010

Ontogeny of Toll-like receptor mediated cytokine responses of human blood mononuclear cells.
Corbett NP, Blimkie D, Ho KC, Cai B, Sutherland DP, Kallos A, Crabtree J, Rein-Weston A, Lavoie PM, Turvey SE, Hawkins NR, Self SG, Wilson CB, Hajjar AM, Fortuno ES, Kollmann TR
DOI: 10.1371/journal.pone.0015041
PubMed: 21152080
11/2010

TLR4 Asp299Gly and Thr399Ile polymorphisms: no impact on human immune responsiveness to LPS or respiratory syncytial virus.
Douville RN, Lissitsyn Y, Hirschfeld AF, Becker AB, Kozyrskyj AL, Liem J, Bastien N, Li Y, Victor RE, Sekhon M, Turvey SE, HayGlass KT
DOI: 10.1371/journal.pone.0012087
PubMed: 20711470
08/2010

Serious musculoskeletal infections in children receiving anti-tumor necrosis factor-alpha therapy: a case series.
Morishita K, Petty R, Cairns R, Bolaria R, Cabral D, Turvey S
DOI: 10.1007/s10067-010-1410-x
PubMed: 20383549
06/2010

Acidification-dependent activation of CD1d-restricted natural killer T cells is intact in cystic fibrosis.
Rzemieniak SE, Hirschfeld AF, Victor RE, Chilvers MA, Zheng D, van den Elzen P, Turvey SE
DOI: 10.1111/j.1365-2567.2009.03234.x
PubMed: 20102408
06/2010

Early outcomes and improvement of patients with juvenile idiopathic arthritis enrolled in a Canadian multicenter inception cohort.
Oen K, Duffy CM, Tse SM, Ramsey S, Ellsworth J, Chédeville G, Chetaille AL, Saint-Cyr C, Cabral DA, Spiegel LR, Schneider R, Lang B, Huber AM, Dancey P, Silverman E, Rosenberg AM, Cameron B, Johnson N, Dorval J, Scuccimarri R
DOI: 10.1002/acr.20044
PubMed: 20391508
04/2010

Innate immunity.
Turvey SE, Broide DH
DOI: 10.1016/j.jaci.2009.07.016
PubMed: 19932920
02/2010

Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome.
Woellner C, Gertz EM, Schäffer AA, Lagos M, Perro M, Glocker EO, Pietrogrande MC, Cossu F, Franco JL, Matamoros N, Pietrucha B, Heropolitanska-Pliszka E, Yeganeh M, Moin M, Español T, Ehl S, Gennery AR, Abinun M, Breborowicz A, Niehues T
DOI: 10.1016/j.jaci.2009.10.059
PubMed: 20159255
02/2010

Toll-like receptors 2 and 4 and the cryopyrin inflammasome in normal pregnancy and pre-eclampsia.
Xie F, Hu Y, Turvey SE, Magee LA, Brunham RM, Choi KC, Krajden M, Leung PC, Money DM, Patrick DM, Thomas E, von Dadelszen P
DOI: 10.1111/j.1471-0528.2009.02428.x
PubMed: 20002372
01/2010

Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity.
Brown KL, Falsafi R, Kum W, Hamill P, Gardy JL, Davidson DJ, Turvey S, Finlay BB, Speert DP, Hancock RE
DOI: 10.1186/1479-5876-8-6
PubMed: 20105294
01/2010

Toll-like receptor signaling and pre-eclampsia.
Xie F, Turvey SE, Williams MA, Mor G, von Dadelszen P
DOI: 10.1111/j.1600-0897.2009.00745.x
PubMed: 20059464
01/2010

Toll-like receptor gene polymorphisms and preeclampsia risk: a case-control study and data synthesis.
Xie F, Hu Y, Speert DP, Turvey SE, Peng G, Money DM, Magee LA, von Dadelszen P, Toxaemia Study Group
DOI: 10.3109/10641950903242659
PubMed: 20818954
2010

Functional characterization of human variants of NFKBIA: a key regulator of immune responsiveness implicated in susceptibility to infectious and inflammatory disease.
Ali S, Hirschfeld A, Victor R, Fortuno ES, Kollmann TR, Turvey SE
DOI: 10.1186/1710-1492-6-s3-p2
2010

Chlamydia pneumoniae infection in preeclampsia.
Xie F, Hu Y, Magee LA, Money DM, Patrick DM, Brunham RM, Thomas E, von Dadelszen P, Toxaemia group
DOI: 10.3109/10641950903242642
PubMed: 20818953
2010

Primary immunodeficiency diseases: a practical guide for clinicians.
Turvey SE, Bonilla FA, Junker AK
DOI: 10.1136/pgmj.2009.080630
PubMed: 20075404
12/2009

Classification, presentation, and initial treatment of Wegener's granulomatosis in childhood.
Cabral DA, Uribe AG, Benseler S, O'Neil KM, Hashkes PJ, Higgins G, Zeft AS, Lovell DJ, Kingsbury DJ, Stevens A, McCurdy D, Chira P, Abramson L, Arkachaisri T, Campillo S, Eberhard A, Hersh AO, Huber AM, Kim S, Klein-Gitelman M
DOI: 10.1002/art.24876
PubMed: 19877069
11/2009

Potential Sources of Phthalate Exposure in a Vancouver, BC Birth Cohort at Three Months of Age
Epidemiology
Tim Takaro, Ryan Allen, Roxanne Rouseau, Michael Brauer, James Scott, Jeff Brook, Stuart Turvey
DOI: 10.1097/01.ede.0000362924.70819.3f
11/2009

Predictors of early inactive disease in a juvenile idiopathic arthritis cohort: results of a Canadian multicenter, prospective inception cohort study.
Oen K, Tucker L, Huber AM, Miettunen P, Scuccimarri R, Campillo S, Cabral DA, Feldman BM, Tse S, Chédeville G, Spiegel L, Schneider R, Lang B, Ellsworth J, Ramsey S, Dancey P, Silverman E, Chetaille AL, Cameron B, Johnson N
DOI: 10.1002/art.24539
PubMed: 19644903
08/2009

Relative CD4 lymphopenia and a skewed memory phenotype are the main immunologic abnormalities in a child with Omenn syndrome due to homozygous RAG1-C2633T hypomorphic mutation.
McCusker C, Hotte S, Le Deist F, Hirschfeld AF, Mitchell D, Nguyen VH, Gagnon R, Mazer B, Turvey SE, Jabado N
DOI: 10.1016/j.clim.2009.01.014
PubMed: 19246248
06/2009

Optimizing outcomes of hematopoietic stem cell transplantation for severe combined immunodeficiency.
Cuvelier GD, Schultz KR, Davis J, Hirschfeld AF, Junker AK, Tan R, Turvey SE
DOI: 10.1016/j.clim.2009.01.003
PubMed: 19217351
05/2009

Epidemiology of asthma: risk factors for development.
Subbarao P, Becker A, Brook JR, Daley D, Mandhane PJ, Miller GE, Turvey SE, Sears MR
DOI: 10.1586/1744666x.5.1.77
PubMed: 20476901
01/2009

Epidemiology of asthma: Risk factors for development
Expert Review of Clinical Immunology
Subbarao, P. and Becker, A. and Brook, J.R. and Daley, D. and Mandhane, P.J. and Miller, G.E. and Turvey, S.E. and Sears, M.R.
DOI: 10.1586/1744666X.5.1.77
2009

Innate immunity mediated by TLR5 as a novel antiinflammatory target for cystic fibrosis lung disease.
Blohmke CJ, Victor RE, Hirschfeld AF, Elias IM, Hancock DG, Lane CR, Davidson AG, Wilcox PG, Smith KD, Overhage J, Hancock RE, Turvey SE
DOI: 10.4049/jimmunol.180.11.7764
PubMed: 18490781
06/2008

Commonly invasive serotypes of Streptococcus pneumoniae trigger a reduced innate immune response compared with serotypes rarely responsible for invasive infection.
Burgess TS, Hirschfeld AF, Tyrrell GJ, Bettinger JA, Turvey SE
DOI: 10.1111/j.1574-695x.2008.00382.x
PubMed: 18248437
06/2008

Commonly invasive serotypes of Streptococcus pneumoniae trigger a reduced innate immune response compared with serotypes rarely responsible for invasive infection
FEMS Immunology and Medical Microbiology
Burgess, T.S.T. and Hirschfeld, A.F. and Tyrrell, G.J. and Bettinger, J.A. and Turvey, S.E.
DOI: 10.1111/j.1574-695X.2008.00382.x
2008

Recurrent systemic pneumococcal disease and IRAK4 deficiency.
Turvey SE, Speert DP
DOI: 10.1097/inf.0b013e318156fb93
PubMed: 17984826
11/2007

Common human Toll-like receptor 4 polymorphisms--role in susceptibility to respiratory syncytial virus infection and functional immunological relevance.
Paulus SC, Hirschfeld AF, Victor RE, Brunstein J, Thomas E, Turvey SE
DOI: 10.1016/j.clim.2007.03.003
PubMed: 17449325
06/2007

Prevalence of Toll-like receptor signalling defects in apparently healthy children who developed invasive pneumococcal infection.
Hirschfeld AF, Bettinger JA, Victor RE, Davidson DJ, Currie AJ, Ansermino JM, Scheifele DW, Orange JS, Turvey SE
DOI: 10.1016/j.clim.2006.10.012
PubMed: 17157070
03/2007

Toll-like receptor 4 polymorphisms and idiopathic chromosomally normal miscarriage.
Hirschfeld AF, Jiang R, Robinson WP, McFadden DE, Turvey SE
DOI: 10.1093/humrep/del377
PubMed: 16982657
02/2007

Recurrent systemic pneumococcal disease and IRAK4 deficiency [1]
Pediatric Infectious Disease Journal
Turvey, S.E. and Speert, D.P.
DOI: 10.1097/INF.0b013e318156fb93
2007

IRAK-4 mutation (Q293X): rapid detection and characterization of defective post-transcriptional TLR/IL-1R responses in human myeloid and non-myeloid cells.
Davidson DJ, Currie AJ, Bowdish DM, Brown KL, Rosenberger CM, Ma RC, Bylund J, Campsall PA, Puel A, Picard C, Casanova JL, Turvey SE, Hancock RE, Devon RS, Speert DP
DOI: 10.4049/jimmunol.177.11.8202
PubMed: 17114497
12/2006

Towards subtlety: understanding the role of Toll-like receptor signaling in susceptibility to human infections.
Turvey SE, Hawn TR
DOI: 10.1016/j.clim.2006.02.003
PubMed: 16563867
07/2006

Detection of a novel nonsense mutation in the interleukin 2 receptor gamma gene causing X-linked severe combined immunodeficiency.
Cohen L, Hirschfeld AF, Junker AK, Davis J, Turvey SE
DOI: 10.1016/s1081-1206(10)63563-6
PubMed: 16680939
04/2006

Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution.
Nishio J, Gaglia JL, Turvey SE, Campbell C, Benoist C, Mathis D
DOI: 10.1126/science.1124004
PubMed: 16556845
03/2006

Questions and answers on immunization.
Paulus S, Turvey S
PubMed: 19030266
02/2006

Old challenges and new directions in pediatric rheumatology.
Cabral DA, Laxer RM, Schrader J, Turvey S, Stevens A, Yeung RS, Foster HE, Emery H, Prendiville J, Tucker LB, Foeldvari I, Sherry DD, Klinkhoff AB, Wallace CA, Houghton K
PubMed: 16395765
01/2006

Old challenges and new directions in pediatric rheumatology
Journal of Rheumatology
Cabral, D.A. and Laxer, R.M. and Schrader, J. and Turvey, S. and Stevens, A. and Yeung, R.S.M. and Foster, H.E. and Emery, H. and Prendiville, J. and Tucker, L.B. and Foeldvari, I. and Sherry, D.D. and Klinkhoff, A.B. and Wallace, C.A. and Houghton, K.
2006

Questions and answers on immunization
Paediatrics and Child Health
Paulus, S. and Turvey, S.
2006

Detection of a novel nonsense mutation in the interleukin 2 receptor ¿ gene causing X-linked severe combined immunodeficiency [2]
Annals of Allergy, Asthma and Immunology
Cohen, L. and Hirschfeld, A.F. and Junker, A.K. and Davis, J. and Turvey, S.E.
2006

Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes.
Turvey SE, Swart E, Denis MC, Mahmood U, Benoist C, Weissleder R, Mathis D
DOI: 10.1172/jci25048
PubMed: 16110329
09/2005

Primary immune deficiencies presenting in adults: seven years of experience from Iran.
Mansouri D, Adimi P, Mirsaedi M, Mansouri N, Tabarsi P, Amiri M, Jamaati HR, Motavasseli M, Baghaii N, Cheraghvandi A, Rouhi R, Roozbahany NA, Zahirifard S, Mohammadi F, Masjedi MR, Velayati AA, Casanova JL, Speert DP, Elwood RK, Schellenberg R
DOI: 10.1007/s10875-005-4124-0
PubMed: 16133995
07/2005

Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes
Journal of Clinical Investigation
Turvey, S.E. and Swart, E. and Denis, M.C. and Mahmood, U. and Benoist, C. and Weissleder, R. and Mathis, D.
DOI: 10.1172/JCI25048
2005

Adverse reactions to vitamin B12 injections due to benzyl alcohol sensitivity: successful treatment with intranasal cyanocobalamin.
Turvey SE, Cronin B, Arnold AD, Twarog FJ, Dioun AF
DOI: 10.1111/j.1398-9995.2004.00507.x
PubMed: 15291924
09/2004

The Wiskott-Aldrich syndrome.
Orange JS, Stone KD, Turvey SE, Krzewski K
DOI: 10.1007/s00018-004-4086-z
PubMed: 15378206
09/2004

Antibiotic desensitization for the allergic patient: 5 years of experience and practice.
Turvey SE, Cronin B, Arnold AD, Dioun AF
DOI: 10.1016/s1081-1206(10)61778-4
PubMed: 15104194
04/2004

Antibiotic desensitization for the allergic patient: 5 Years of experience and practice
Annals of Allergy, Asthma and Immunology
Turvey, S.E. and Cronin, B. and Arnold, A.D. and Dioun, A.F.
DOI: 10.1016/S1081-1206(10)61778-4
2004

Rituximab therapy for multisystem autoimmune diseases in pediatric patients.
Binstadt BA, Caldas AM, Turvey SE, Stone KD, Weinstein HJ, Jackson J, Fuhlbrigge RC, Sundel RP
DOI: 10.1067/s0022-3476(03)00382-2
PubMed: 14615729
11/2003

Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge.
MacGinnitie AJ, Walensky LD, Turvey SE, Orange JS, Bonilla FA, Silverman LB, Oettgen H
DOI: 10.1034/j.1399-3038.2003.00073.x
PubMed: 14641613
10/2003

Churg-Strauss syndrome in a 7-year-old receiving montelukast and inhaled corticosteroids.
Turvey SE, Vargas SO, Phipatanakul W
DOI: 10.1016/s1081-1206(10)62156-4
PubMed: 12602680
02/2003

Churg-Strauss syndrome in a 7-year-old receiving montelukast and inhaled corticosteroids [1]
Annals of Allergy, Asthma and Immunology
Turvey, S.E. and Vargas, S.O. and Phipatanakuly, W.
2003

Rituximab Therapy for Multisystem Autoimmune Diseases in Pediatric Patients
Journal of Pediatrics
Binstadt, B.A. and Caldas, A.M.C. and Turvey, S.E. and Weinstein, H.J. and Jackson, J. and Fuhlbrigge, R.C. and Sundel, R.P.
DOI: 10.1067/S0022-3476(03)00382-2
2003

Atopic diseases of childhood.
Turvey SE
DOI: 10.1097/00008480-200110000-00017
PubMed: 11801897
10/2001

IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo.
Hara M, Kingsley CI, Niimi M, Read S, Turvey SE, Bushell AR, Morris PJ, Powrie F, Wood KJ
DOI: 10.4049/jimmunol.166.6.3789
PubMed: 11238621
03/2001

Differential susceptibility of heart, skin, and islet allografts to T cell-mediated rejection.
Jones ND, Turvey SE, Van Maurik A, Hara M, Kingsley CI, Smith CH, Mellor AL, Morris PJ, Wood KJ
DOI: 10.4049/jimmunol.166.4.2824
PubMed: 11160350
02/2001

Islet allograft rejection can be mediated by CD4+, alloantigen experienced, direct pathway T cells of TH1 and TH2 cytokine phenotype.
Barbara JA, Turvey SE, Kingsley CI, Spriewald BM, Hara M, Witzke O, Morris PJ, Wood KJ
DOI: 10.1097/00007890-200012150-00017
PubMed: 11152227
12/2000

Fas ligand-transfected myoblasts and islet cell transplantation.
Turvey SE, Gonzalez-Nicolini V, Kingsley CI, Larregina AT, Morris PJ, Castro MG, Lowenstein PR, Wood KJ
DOI: 10.1097/00007890-200005150-00043
PubMed: 10830245
05/2000

Fas ligand-transfected myoblasts and islet cell transplantation
Transplantation
Turvey, S.E. and Gonzalez-Nicolini, V. and Kingsley, C.I. and Larregina, A.T. and Morris, P.J. and Castro, M.G. and Lowenstein, P.R. and Wood, K.J.
2000

Islet allograft rejection can be mediated by CD4
Transplantation
Barbara, J.A.J. and Turvey, S.E. and Kingsley, C.I. and Spriewald, B.M. and Hara, M. and Witzke, O. and Morris, P.J. and Wood, K.J.
2000

Mechanisms of tolerance induction after intrathymic islet injection: determination of the fate of alloreactive thymocytes.
Turvey SE, Hara M, Morris PJ, Wood KJ
DOI: 10.1097/00007890-199907150-00007
PubMed: 10428263
07/1999

The visualization of T cell responses.
Barbara JA, Gilot BJ, Hara M, Van Maurik A, Jones ND, Turvey SE, Wood KJ
DOI: 10.1097/00007890-199906270-00002
PubMed: 10401755
06/1999

New insights on the mechanisms of acquired intrathymic tolerance
Current Opinion in Organ Transplantation
Stuart E. Turvey, Jeremy W. Fry, Kathryn J. Wood
DOI: 10.1097/00075200-199903000-00010
03/1999

Islet allografts: Rejection and tolerance induction
Transplantation Proceedings
Turvey, S.E. and Morris, P.J. and Wood, K.J.
DOI: 10.1016/S0041-1345(98)01597-8
1999

Direct allorecognition: A mechanism in intrathymic tolerance induction
Transplantation Proceedings
Turvey, S.E. and Hara, M. and Morris, P.J. and Wood, K.J.
DOI: 10.1016/S0041-1345(98)01798-9
1999

Direct allorecognition: a mechanism in intrathymic tolerance induction.
Turvey SE, Hara M, Morris PJ, Wood KJ
DOI: 10.1016/s0041-1345(98)01798-9
PubMed: 10083367
1999

Islet allografts: rejection and tolerance induction.
Turvey SE, Morris PJ, Wood KJ
DOI: 10.1016/s0041-1345(98)01597-8
PubMed: 10083277
1999

Immunobiology of solid organ transplantation.
Turvey SE, Wood KJ
PubMed: 10667806
1999

Immunobiology of solid organ transplantation
International Surgery
Turvey, S.E. and Wood, K.J.
1999

Mechanisms of tolerance induction after intrathymic islet injection: Determination of the fate of alloreactive thymocytes
Transplantation
Turvey, S.E. and Hara, M. and Morris, P.J. and Wood, K.J.
1999

Changes in myoplasmic sodium concentration during exposure to lactate in perfused rat heart.
Turvey SE, Allen DG
PubMed: 7954611
07/1994

Changes in myoplasmic sodium concentration during exposure to lactate in perfused rat heart
Cardiovascular Research
Turvey, S.E. and Allen, D.G.
DOI: 10.1093/cvrese/28.7.987
1994

Intracellular calcium and myocardial function during ischemia
Advances in Experimental Medicine and Biology
Allen, D.G. and Cairns, S.P. and Turvey, S.E. and Lee, J.A. and Rudy, Y. and Marban, E. and Hasenfuss, G. and De Mey, J. and Chilian, W.M.
1993

Intracellular calcium and myocardial function during ischemia.
Allen DG, Cairns SP, Turvey SE, Lee JA
PubMed: 8184757
1993

Intracellular Calcium and Myocardial Function During Ischemia
Interactive Phenomena in the Cardiac System
David G. Allen, Simeon P. Cairns, Stuart E. Turvey, John A. Lee
DOI: 10.1007/978-1-4615-2946-0_3
1993

Research

Canadian Healthy Infant Longitudinal Development (CHILD) Study
Over the past 30 years there has been an increasing concern about the effects of environment on health. In particular, since infants spend the majority of their time indoors, there is intense interest in the impact indoor pollution has on the health of our children. Our indoor environment has become a public health priority as growing evidence suggests that unseen environmental contaminants in our living spaces may have important effects on children's health and development.

The Canadian Healthy Infant Longitudinal Development (CHILD) Study is a multicentre, multidisciplinary, longitudinal, population-based birth-cohort study of 5,000 children enrolled "pre-birth" and followed for five years (www.canadianchildstudy.ca). The main purpose of this study is to determine what aspects of the environment interact with genetic factors to affect children’s health and development. I am a co-principal investigator for the CHILD study and I lead the Vancouver study site.

Innate Immunity and Lung Inflammation in Cystic Fibrosis
Cystic fibrosis (CF) is the most common, deadly genetic disease affecting young Canadians. Even today, only half of the people living with CF will survive beyond their mid-thirties. New treatments for CF are critically needed.

Lung disease is the major life-limiting factor for people living with CF. Lung injury in CF occurs through a vicious cycle of airway blockage, infection and inflammation. Current CF treatments rely upon physiotherapy to reduce airway blockage and antibiotics to treat the infections, but these treatments do not specifically deal with inflammation. New treatments to simultaneously target airway inflammation are likely to provide substantial additional benefits in improving the quality and length of life for those with CF.

Through synergistic studies harnessing the power of cell biology, chemistry and functional genomics, we are working to identify optimal "druggable" targets responsible for CF airway inflammation and to discover novel anti-inflammatory drugs. Ultimately, these experiments are designed to develop new therapies for safely reducing lung inflammation and improving the quality and length of life of people with CF.

Genetics of Susceptibility to Childhood Infection
Until very recently, clinical immunologists have focused most attention on patients with a ‘noisy clinical phenotype’—multiple, severe and recurrent infections. Indeed, the origin of primary immunodeficiencies is generally attributed to Bruton’s 1952 description of X-linked agammaglobulinemia in a boy whose repeated pneumococcal infections demanded clinical attention.

Today, enhanced understanding of human immunity combined with ever more sophisticated tools to dissect the immune response have allowed clinical immunologists to look beyond these "noisy", severely immunocompromised patients to individuals with less obvious immune defects. We have entered the era of "subtle" primary immunodeficiencies that will begin to precipitate a fundamental change and expansion of the focus of clinical immunologists.

My lab is involved in searching for subtle genetic immune defects in apparently healthy children who developed serious infections, including invasive pneumococcal infection and severe respiratory syncytial virus infection. This journey towards subtlety is anticipated to translate into better care for our patients through improved diagnosis, combined with tailored treatment and targeted prophylaxis.

Honours & Awards

Aubrey J. Tingle Professorship in Pediatric Immunology, 2012-Present

Canadian Society of Allergy and Clinical Immunology, Award for Research in Immunology 2013

Career Investigator Scholar Award, Michael Smith Foundation for Health Research, 2011-19.

Research Group Members

Linda Warner, Clinical Research Coordinator
Mary Beckingham, Research Assistant
Darlene Dai, Biostatistician
Kate Del Bel, Research Manager
Valerie Tolsma, Administrative Assistant
Henry Lu, Graduate Trainee
Lauren Muttucomaroe, Research Assistant
Hind Sbihi, Postdoctoral Felllow
Catherine Biggs, Masters Student
Shan-Yu Fung
Geraldine Blanchard, Visiting Clinician
Mandy Suen, Research Assistant
Chelsea Cutler, Masters Student
Mehul Sharma, Research Assistant
Maureen Mooney, Clinical Research Nurse
Tamara Coffin, Clinical Research Assistant